Prescription ID | TCMF4745 |
Pinyin Name | Qi Bao Mei Ran Chong Ji |
Chinese Name | 七宝美髯冲剂 |
English Name | Qi Bao Mei Ran Infusion |
Function Description | 遗精, 早泄, 眩晕, 耳鸣, 腰痛 |
Indications | Premature ejaculation disorder, Involuntary ejaculation disorder, Lumbago disorder, Tinnitus disorder, Vertigo disorder, Tinnitus, Dizziness, Lumbago, Premature ejaculation |
Disease ICD-11 Category |
SB08 [Premature ejaculation disorder (TM1), 早泄 (TM1)
]; SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ]; SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ]; SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ]; SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ]; MC41 [Tinnitus, 耳鸣 ]; MB48 [Dizziness and giddiness, 头晕和眩晕 ]; ME84.2Z [Low back pain, unspecified, 下腰痛,未特指的 ]; HA03.0Z [Male early ejaculation, unspecified, 男性早泄,未特指的 ]; |
Human Tissues Associated with Indication | Brain, Kidney, Bladder |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH819 | Polygonum multiflorum | 何首乌 | TCMH819 | ITSAL419-14 |
TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
TCMH193 | Psoralea corylifolia | 补骨脂 | TCMH193 | |
TCMH1186 | Lycium chinense | 枸杞子 | TCMH1186 | ITSAO4545-14 |
TCMH2149 | Cuscuta australis | 菟丝子 | TCMH2149 | ITSAP4209-14 |
TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
TCMH1588 | Achyranthes bidentata | 牛膝 | TCMH1588 | ITSAJ4612-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT139 | CA6 | Carbonic anhydrase VI | Lyase | P23280 |
TCMT140 | CA5B | Carbonic anhydrase VB | Lyase | Q9Y2D0 |
TCMT141 | CA5A | Carbonic anhydrase VA | Lyase | P35218 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT164 | PTGS1 | Cyclooxygenase-1 | Oxidoreductase | P23219 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT290 | CHRM5 | Muscarinic acetylcholine receptor M5 | GPCR | P08912 |
TCMT291 | CHRM3 | Muscarinic acetylcholine receptor M3 | GPCR | P20309 |
TCMT292 | CHRM1 | Muscarinic acetylcholine receptor M1 | GPCR | P11229 |
TCMT293 | CHRM2 | Muscarinic acetylcholine receptor M2 | GPCR | P08172 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT30 | PTGS2 | Cyclooxygenase-2 | Oxidoreductase | P35354 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT329 | NQO2 | Quinone reductase 2 | Oxidoreductase | P16083 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT619 | HSP90AA1 | Heat shock protein HSP 90-alpha | Unclassified | P07900 |
TCMT624 | HSP90AB1 | Heat shock protein HSP 90-beta | Unclassified | P08238 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT653 | GRM1 | Metabotropic glutamate receptor 1 | GPCR | Q13255 |
TCMT654 | GRM5 | Metabotropic glutamate receptor 5 | GPCR | P41594 |
TCMT655 | GRM2 | Metabotropic glutamate receptor 2 | GPCR | Q14416 |
TCMT656 | GRM3 | Metabotropic glutamate receptor 3 | GPCR | Q14832 |
TCMT657 | GRM4 | Metabotropic glutamate receptor 4 | GPCR | Q14833 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT660 | GRM8 | Metabotropic glutamate receptor 8 | GPCR | O00222 |
TCMT664 | SLC1A1 | Excitatory amino acid transporter 3 | Transporter | P43005 |
TCMT67 | PPARG | Peroxisome proliferator-activated receptor gamma | Nuclear receptor | P37231 |
TCMT690 | HDAC3 | Histone deacetylase 3 | Hydrolase | O15379 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT729 | PIK3CA | PI3-kinase p110-alpha subunit | Transferase | P42336 |
TCMT730 | PIK3CB | PI3-kinase p110-beta subunit | Transferase | P42338 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1179 | Escherichia coli ATCC 8739 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1182 | Streptococcus sanguinis |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1191 | Bacillus megaterium |
TCMT1208 | Escherichia coli K12 |
TCMT1211 | Fusobacterium nucleatum |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1217 | Bacillus anthracis |
TCMT1218 | Staphylococcus aureus |
TCMT1221 | Human herpesvirus 4 |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1229 | Enterococcus faecalis |
TCMT1231 | Human herpesvirus 1 strain KOS |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1236 | Mycobacterium bovis |
TCMT1245 | Phytophthora cactorum |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1260 | Streptococcus agalactiae |
TCMT1286 | Bacillus cereus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1319 | Corynebacterium xerosis |
TCMT1322 | Streptococcus mitis |
TCMT1323 | Corynebacterium pseudodiphtheriticum |
TCMT1324 | Corynebacterium diphtheriae |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1390 | Human herpesvirus 2 strain G |
TCMT1408 | Colletotrichum gloeosporioides |
TCMT1410 | Listeria monocytogenes |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1444 | Fusarium oxysporum |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 11.6198 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.7395 |
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2 | 10.3009 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIK3CA, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR, XDH | 9.52833 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, KDR, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, SLC1A1, SRC, XDH | 9.52833 |
[BP] GO:0007215 | None | APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 8.33769 |
[BP] GO:0007193 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 | 8.05466 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR | 7.89825 |
[BP] GO:0019369 | arachidonic acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 7.74296 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, GRIK5, GRM5, HSD17B2, HSP90AB1, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PPARG, PTGS2, SRC, TYR | 7.43462 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 7.21107 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 6.95788 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1 | 6.79507 |
[BP] GO:0010033 | response to organic substance | AKR1B1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP2, PIK3CA, PPARA, PPARG, PTGS2, SRC, TYR | 6.71479 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG, PTGS1, PTGS2 | 6.46653 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2 | 6.4117 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, XDH | 6.3482 |
[BP] GO:0007197 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.3482 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PTGS2, PTPN1, SRC, XDH | 6.25909 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD17B1, HSD17B2 | 6.24568 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, NQO2, PPARG, PTGS1, PTGS2, TYR, XDH | 6.15226 |
[BP] GO:0007207 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 5.95353 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 5.93857 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 5.75967 |
[BP] GO:0007188 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 | 5.74461 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, MET, PIK3CA, PIK3CB, PPARG, SRC | 5.69589 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PTGS2, PTPN1, SRC, XDH | 5.68646 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1 | 5.64342 |
[BP] GO:0042221 | response to chemical | AKR1B1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PPARG, PTGS2, SRC, TYR | 5.64251 |
[BP] GO:0050804 | modulation of chemical synaptic transmission | ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 | 5.51949 |
[BP] GO:0099177 | regulation of trans-synaptic signaling | ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 | 5.51949 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.46043 |
[BP] GO:0007187 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 | 5.25315 |
[BP] GO:0007196 | None | GRM1, GRM3, GRM5, GRM8 | 5.20526 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, XDH | 5.19424 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HCAR2, HSP90AB1, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.10233 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, XDH | 5.08517 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HCAR2, HSP90AB1, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.08517 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SLC1A1, SRC, XDH | 5.08517 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 4.98239 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, XDH | 4.92016 |
[BP] GO:0007165 | signal transduction | ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTPN1, SRC | 4.75857 |
[BP] GO:0051966 | regulation of synaptic transmission, glutamatergic | ADORA1, GRM1, GRM3, GRM5, GRM8, PTGS2 | 4.74762 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, APP, CDC25B, CHRM5, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 4.74077 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC | 4.71312 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, APP, CDC25B, CHRM5, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 4.69306 |
[BP] GO:0007268 | None | CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 | 4.69306 |
[BP] GO:0098916 | None | CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 | 4.69306 |
[BP] GO:0099536 | None | CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 | 4.61548 |
[BP] GO:0099537 | None | CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 | 4.61548 |
[BP] GO:0032787 | None | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG, PTGS1, PTGS2 | 4.58722 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 4.5692 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, APP, CDC25B, CHRM1, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PPARG, PTGS1, PTGS2, SRC, XDH | 4.5637 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARG, PTGS2, SRC | 4.5573 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH | 4.52714 |
[BP] GO:0007216 | None | GRM1, GRM3, GRM5, GRM8 | 4.47502 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, APP, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, MMP2, PIK3CA, PPARG, PTGS2, SRC | 4.47049 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HSP90AB1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC | 4.46174 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, HSP90AB1, NQO2, PTGS1 | 4.45213 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 4.4499 |
[BP] GO:0033993 | response to lipid | AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PPARG, PTGS2, SRC, TYR | 4.39505 |
[BP] GO:0014070 | response to organic cyclic compound | APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSP90AB1, PPARG, PTGS2, SRC, TYR | 4.36312 |
[BP] GO:0048010 | vascular endothelial growth factor receptor signaling pathway | AXL, HSP90AA1, KDR, PIK3CA, PIK3CB, SRC | 4.34809 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PPARG, PTGS2, SRC | 4.29505 |
[BP] GO:0007213 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.26393 |
[BP] GO:0007154 | None | ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, PTGS2, SLC1A1 | 4.23206 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HSP90AB1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 4.23206 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 4.23068 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APP, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PIK3CA, PPARG, PTGS2, SRC | 4.2001 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH | 4.2001 |
[BP] GO:0007186 | G-protein coupled receptor signaling pathway | ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PIK3CA, PIK3CB, PPARG, SRC | 4.16706 |
[BP] GO:0051338 | regulation of transferase activity | ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, PIK3CA, PIK3CB, PPARG, PTPN1, SRC | 4.14665 |
[BP] GO:0006811 | None | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, SLC1A1 | 4.10621 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR | 4.10175 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC | 4.08103 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, HSP90AB1, KDR, PIK3CA, PPARA, PPARG, SRC, TYR | 3.99362 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PPARG, PTGS2, SRC | 3.99362 |
[BP] GO:0007200 | None | CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 | 3.9518 |
[BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR, XDH | 3.89167 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, APP, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB, PPARG | 3.85926 |
[BP] GO:0051972 | regulation of telomerase activity | AURKB, HSP90AA1, HSP90AB1, PPARG, SRC | 3.85926 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, APP, CDC25B, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.85186 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SRC, TYR | 3.7581 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, APP, CDC25B, FABP3, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.75457 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, APP, CDC25B, FABP3, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.75457 |
[BP] GO:0095500 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.70651 |
[BP] GO:1903831 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.70651 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AXL, CYP1B1, FLT3, GRM1, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.70608 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HSP90AB1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 3.65238 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, APP, CDC25B, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.64493 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.64493 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR | 3.64493 |
[BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.64493 |
[BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.64493 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AB1, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARG, PTGS2, PTPN1, SRC | 3.6441 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, APP, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC | 3.64104 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, GRM1, HSP90AA1, HSP90AB1, MMP2, PPARA, PPARG, PTGS2, SRC, TYR | 3.59065 |
[BP] GO:0007267 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 | 3.58642 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR | 3.56086 |
[BP] GO:0050790 | regulation of catalytic activity | ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, IGF1R, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, XDH | 3.54565 |
[BP] GO:0035235 | None | APP, GRIA2, GRIA4, GRIK5 | 3.52959 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APP, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, PTGS2, SRC, TYR | 3.49998 |
[BP] GO:0007271 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.46702 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRM1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.40711 |
[BP] GO:0009725 | response to hormone | AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, PPARG, PTGS2, SRC | 3.38246 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD17B2, HSP90AB1, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, SRC, TYR | 3.36933 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 3.36168 |
[BP] GO:0045859 | regulation of protein kinase activity | ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 3.34468 |
[BP] GO:0006940 | None | ADORA1, CHRM1, CHRM2, CHRM3, PTGS2 | 3.3412 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 | 3.3343 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, HSP90AB1, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.3343 |
[BP] GO:1901652 | response to peptide | AKR1B1, APP, FABP3, GRM5, IGF1R, PPARA, PPARG, PTGS2, SRC | 3.31355 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 3.30985 |
[BP] GO:0071407 | cellular response to organic cyclic compound | APP, CYP1A1, CYP1B1, ESR1, FLT3, HSP90AB1, PPARG, PTGS2, SRC | 3.30143 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC | 3.26953 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.25768 |
[BP] GO:0051347 | positive regulation of transferase activity | ADORA1, AURKB, CDC25B, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PTPN1, SRC | 3.24858 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC | 3.23157 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR | 3.22656 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, PPARG, PTGS2, SRC | 3.22013 |
[BP] GO:2001225 | regulation of chloride transport | CA2, CA7, GRM5 | 3.20309 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.20309 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APP, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, PTGS2, SRC, TYR | 3.20207 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD17B2, HSP90AB1, KDR, MMP9, PIK3CA, PIM1, PPARA, PPARG, PTGS2, SRC, TYR | 3.19465 |
[BP] GO:0023052 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 | 3.18584 |
[BP] GO:0006082 | organic acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR | 3.15577 |
[BP] GO:0065009 | regulation of molecular function | ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, FABP4, FLT3, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, XDH | 3.15364 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC | 3.15292 |
[BP] GO:0044093 | positive regulation of molecular function | ADORA1, APP, AURKB, CDC25B, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, MET, MMP9, PIK3CA, PIK3CB, PPARG, PTPN1, SRC, XDH | 3.13533 |
[BP] GO:0019371 | None | CBR1, PTGS1, PTGS2 | 3.09534 |
[BP] GO:0043549 | regulation of kinase activity | ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 3.0742 |
[BP] GO:0060078 | None | ADORA1, GRIA2, GRIA4, GRIK5, GRM5 | 3.05064 |
[BP] GO:0043393 | regulation of protein binding | APP, AURKB, HSP90AB1, MET, MMP9, PPARA, SRC | 3.0467 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ADORA1, APP, CDC25B, CSNK2A1, ESR1, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, XDH | 3.00386 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2 | 2.90974 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, GRM1, HSP90AA1, HSP90AB1, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.90552 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.88624 |
[BP] GO:0045860 | positive regulation of protein kinase activity | ADORA1, CDC25B, FLT3, GRM1, GRM5, HSP90AB1, PIK3CA, PIK3CB, PTPN1, SRC | 2.87966 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, APP, CHRM1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARG, PTGS2, SRC | 2.87966 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, HSP90AA1, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH | 2.87667 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARG, PTGS2, SRC | 2.80683 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.80266 |
[BP] GO:0051049 | regulation of transport | ACHE, ADORA1, APP, AXL, CA2, CA7, CHRM1, CYP19A1, GRIK5, GRM5, HCAR2, HSP90AB1, MMP9, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC | 2.80266 |
[BP] GO:0031401 | positive regulation of protein modification process | ADORA1, APP, CDC25B, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.77099 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ADORA1, APP, CDC25B, ESR1, FLT3, GRM1, GRM5, HSP90AB1, KDR, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, XDH | 2.75892 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, FABP3, HSD17B2, KDR, MMP2, PPARG, PTGS2, SRC | 2.7551 |
[BP] GO:0006810 | None | ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, SRC, XDH | 2.71159 |
[BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIK3CA, PIM1, SRC | 2.6826 |
[BP] GO:0033674 | positive regulation of kinase activity | ADORA1, CDC25B, FLT3, GRM1, GRM5, HSP90AB1, PIK3CA, PIK3CB, PTPN1, SRC | 2.67804 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.64212 |
[BP] GO:0043085 | positive regulation of catalytic activity | ADORA1, APP, AURKB, CDC25B, ESR1, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PPARG, PTPN1, SRC, XDH | 2.58278 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APP, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC | 2.58278 |
[BP] GO:0051098 | regulation of binding | APP, AURKB, HSP90AB1, MET, MMP9, PPARA, PPARG, SRC | 2.58278 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARG, PTGS2, SRC | 2.57355 |
[BP] GO:0031399 | regulation of protein modification process | ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.55149 |
[BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, GRIK5, HSP90AA1, HSP90AB1, PTGS2, SLC1A1 | 2.51707 |
[BP] GO:2000278 | regulation of DNA biosynthetic process | AURKB, HSP90AA1, HSP90AB1, PPARG, SRC | 2.48151 |
[BP] GO:0030522 | intracellular receptor signaling pathway | ESR1, ESR2, PIM1, PPARA, PPARG, SRC | 2.47542 |
[BP] GO:0099566 | None | GRM1, GRM5 | 2.46463 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.46463 |
[BP] GO:0080134 | regulation of response to stress | ADORA1, APP, CYP19A1, ESR1, FABP4, HSP90AA1, HSP90AB1, IGF1R, MET, MMP2, PPARA, PPARG, PTGS2, PTPN1, SRC, XDH | 2.45672 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, MMP9, SRC | 2.44333 |
[BP] GO:0051234 | None | ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, SRC, XDH | 2.42996 |
[BP] GO:0016310 | phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.42845 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, CA2, CA7, HCAR2, KDR, PIK3CB, PTGS2, SRC | 2.42626 |
[BP] GO:0051179 | None | ACHE, ADORA1, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, SRC, XDH | 2.4193 |
[BP] GO:0048608 | reproductive structure development | AXL, CYP19A1, ESR1, HSD17B2, HSP90AB1, PPARG, SRC | 2.39451 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 | 2.39451 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, APP, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, XDH | 2.37652 |
[BP] GO:0042493 | response to drug | AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, HSP90AB1, KDR, PPARG, PTGS2, SRC | 2.36804 |
[BP] GO:0071498 | cellular response to fluid shear stress | CA2, PTGS2, SRC | 2.33542 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, CDC25B, CHRM1, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2 | 2.32055 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, AXL, CYP1B1, HSP90AB1, KDR, PTGS2, SRC | 2.291 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARG, PTGS2, SRC | 2.28519 |
[BP] GO:0030520 | intracellular estrogen receptor signaling pathway | ESR1, ESR2, SRC | 2.28484 |
[BP] GO:0046903 | None | ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, HSP90AA1, HSP90AB1, MMP9, SLC1A1, XDH | 2.2804 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD17B1, HSD17B2 | 2.27755 |
[BP] GO:1903522 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, PTGS2, SLC1A1 | 2.27561 |
[BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, APP, CA2, CA7, PTGS2 | 2.2526 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.23691 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, APP, AURKB, CDC25B, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, XDH | 2.23685 |
[BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APP, GRM5, IGF1R, MMP2, PPARG, PTGS2, SRC | 2.23685 |
[BP] GO:0070482 | response to oxygen levels | ADORA1, CYP1A1, MMP2, PPARA, PPARG, PTGS2, SRC | 2.23685 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, APP, FLT3, GRM1, KDR, PIK3CB, PTPN1, SRC, XDH | 2.23685 |
[BP] GO:1905323 | None | HSP90AA1, HSP90AB1 | 2.23685 |
[BP] GO:0033031 | positive regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.23685 |
[BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.23685 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.23685 |
[BP] GO:2000573 | positive regulation of DNA biosynthetic process | AURKB, HSP90AA1, HSP90AB1, SRC | 2.21987 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, APP, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, XDH | 2.21623 |
[BP] GO:0042391 | None | ADORA1, APP, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC | 2.2096 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, PTGS2, SRC | 2.2096 |
[BP] GO:0035902 | response to immobilization stress | CYP1A1, CYP1A2, PPARG | 2.20557 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.20557 |
[BP] GO:0044057 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, GRM1, HCAR2, PTGS2, SLC1A1 | 2.19688 |
[BP] GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | CSNK2A1, MMP9, PPARG, PTGS2, SRC, XDH | 2.17595 |
[BP] GO:0048660 | regulation of smooth muscle cell proliferation | AKR1B1, MMP2, MMP9, PPARG, PTGS2 | 2.16854 |
[BP] GO:0051239 | regulation of multicellular organismal process | ADORA1, ADORA3, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, ESR1, GRM1, HCAR2, HSP90AB1, KDR, MET, MMP9, PIK3CA, PIM1, PPARG, PTGS2, SLC1A1, SRC, XDH | 2.16295 |
[BP] GO:0031347 | regulation of defense response | ADORA1, CYP19A1, ESR1, FABP4, HSP90AB1, MMP2, PPARA, PPARG, PTGS2, PTPN1, SRC | 2.16295 |
[BP] GO:1901653 | cellular response to peptide | AKR1B1, APP, GRM5, IGF1R, PPARG, SRC | 2.15897 |
[BP] GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, SRC | 2.1458 |
[BP] GO:0043401 | steroid hormone mediated signaling pathway | ESR1, ESR2, PPARA, PPARG, SRC | 2.1458 |
[BP] GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, SRC | 2.1458 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, MET, PIK3CA, PIK3CB, SRC, XDH | 2.13231 |
[BP] GO:0002431 | Fc receptor mediated stimulatory signaling pathway | HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, SRC | 2.11941 |
[BP] GO:0060079 | None | ADORA1, GRIA2, GRIA4, GRIK5 | 2.11941 |
[BP] GO:0010632 | regulation of epithelial cell migration | KDR, MET, MMP9, PPARG, PTGS2, SRC | 2.09261 |
[BP] GO:0038094 | Fc-gamma receptor signaling pathway | HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, SRC | 2.09261 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH | 2.09236 |
[BP] GO:1904646 | cellular response to amyloid-beta | APP, GRM5, IGF1R | 2.07745 |
[BP] GO:1903725 | regulation of phospholipid metabolic process | CHRM5, FABP3, FLT3, SRC | 2.06396 |
[BP] GO:0030100 | regulation of endocytosis | APP, AXL, PIK3CB, PPARG, PTPN1, SRC | 2.06396 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, APP, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, XDH | 2.06396 |
[BP] GO:0046541 | None | CHRM1, CHRM3 | 2.06396 |
[BP] GO:0032800 | receptor biosynthetic process | ACHE, PPARG | 2.06396 |
[BP] GO:0010891 | None | PPARA, PPARG | 2.06396 |
[BP] GO:0051050 | positive regulation of transport | ACHE, ADORA1, APP, AXL, CA2, CHRM1, CYP19A1, HCAR2, HSP90AB1, PPARG, PTGS2, SRC | 2.05341 |
[BP] GO:1901699 | cellular response to nitrogen compound | AKR1B1, APP, GRM5, IGF1R, MMP2, PPARG, PTGS2, SRC | 2.05106 |
[BP] GO:0010038 | response to metal ion | APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 2.04501 |
[BP] GO:0046320 | None | FABP3, PPARA, PPARG | 2.04501 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APP, ESR1, FLT3, GRM5, IGF1R, MMP2, PPARG, PTGS2, SRC | 2.03545 |
[BP] GO:0006950 | response to stress | ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, HSP90AA1, HSP90AB1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SRC | 2.03488 |
[BP] GO:0061097 | None | ADORA1, APP, GRM5, PTPN1 | 2.03104 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2 | 2.00495 |
[CC] GO:0098590 | plasma membrane region | ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, MET, PTGS2, SLC1A1, SRC | 7.85259 |
[CC] GO:0097060 | None | CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 5.68421 |
[CC] GO:0044456 | None | ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC | 5.26399 |
[CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC1A1, SRC | 4.63286 |
[CC] GO:0044459 | plasma membrane part | ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PTGS2, SLC1A1, SRC | 4.52714 |
[CC] GO:0031226 | intrinsic component of plasma membrane | ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 | 4.04847 |
[CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR | 4.00629 |
[CC] GO:0043005 | None | ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC | 3.98077 |
[CC] GO:0044463 | None | ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, PTGS1, SRC | 3.9639 |
[CC] GO:0120038 | None | ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, PTGS1, SRC | 3.9639 |
[CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR | 3.9518 |
[CC] GO:0045211 | None | CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 | 3.87454 |
[CC] GO:0005887 | integral component of plasma membrane | ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 | 3.70651 |
[CC] GO:0042734 | None | GRIK5, GRM1, GRM3, GRM5, GRM8 | 3.42663 |
[CC] GO:0014069 | None | ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC | 3.13368 |
[CC] GO:0099572 | None | ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC | 3.13368 |
[CC] GO:0120025 | None | ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SRC | 2.96885 |
[CC] GO:0042995 | cell projection | ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SRC | 2.70683 |
[CC] GO:0097458 | None | ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS1, PTGS2, SRC | 2.65528 |
[CC] GO:0098793 | None | ADORA1, APP, CHRM1, CHRM2, CHRM3, GRIK5 | 2.58475 |
[CC] GO:0045202 | None | ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2 | 2.47099 |
[CC] GO:0016323 | basolateral plasma membrane | ADORA1, CA2, CA4, CA9, CHRM3, HSP90AB1 | 2.36763 |
[CC] GO:0043197 | None | ADORA1, APP, GRIA2, GRIA4, GRM3 | 2.29084 |
[CC] GO:0044309 | None | ADORA1, APP, GRIA2, GRIA4, GRM3 | 2.2681 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARG, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH | 2.04037 |
[CC] GO:0043235 | receptor complex | APP, GRIA2, GRIA4, GRIK5, GRM1, HSP90AB1, IGF1R | 2.02692 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 17.0253 |
[MF] GO:0046914 | transition metal ion binding | ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PPARG, PTPN1, TYR, XDH | 14.3177 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.7395 |
[MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 9.52833 |
[MF] GO:0043167 | ion binding | ACHE, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR, XDH | 8.39922 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, HSD17B1, HSD17B2, HSP90AA1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH | 8.33769 |
[MF] GO:0008066 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 8.1636 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PPARG | 6.89328 |
[MF] GO:0030594 | None | CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 | 6.81444 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PPARA, PPARG, PTPN1 | 6.66162 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, SRC | 6.58022 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 6.57378 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 6.50426 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC | 6.3482 |
[MF] GO:0016907 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.3482 |
[MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 6.26776 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC | 6.14414 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PPARG | 6.13458 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PPARG | 5.89989 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TYR | 5.75967 |
[MF] GO:0099600 | transmembrane receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARG | 5.58668 |
[MF] GO:0004888 | transmembrane signaling receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARG | 5.58668 |
[MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, PPARG | 5.4634 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 | 5.25934 |
[MF] GO:0043169 | cation binding | ACHE, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, TYR, XDH | 5.19327 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR | 4.88157 |
[MF] GO:0005506 | iron ion binding | ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH | 4.61548 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH | 4.5637 |
[MF] GO:0046872 | metal ion binding | ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC1A1, TYR, XDH | 4.27398 |
[MF] GO:0015464 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.08237 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 | 4.00629 |
[MF] GO:0030235 | nitric-oxide synthase regulator activity | ESR1, HSP90AA1, HSP90AB1 | 3.64493 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.42663 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC | 3.3343 |
[MF] GO:0004629 | None | ADORA1, CHRM1, CHRM3, CHRM5 | 3.31348 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6 | 3.13533 |
[MF] GO:0043560 | insulin receptor substrate binding | IGF1R, PIK3CA, PIK3CB | 3.09534 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH | 3.0126 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.00386 |
[MF] GO:0042802 | identical protein binding | ACHE, APP, CSNK2A1, ESR1, ESR2, FLT3, GRIK5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NQO2, PPARG, PTGS2, TYR, XDH | 2.98032 |
[MF] GO:0099528 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 2.96885 |
[MF] GO:0004666 | prostaglandin-endoperoxide synthase activity | PTGS1, PTGS2 | 2.87667 |
[MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.87667 |
[MF] GO:0008389 | None | CYP2A13, CYP2A6 | 2.87667 |
[MF] GO:0042562 | hormone binding | ACHE, CHRM3, HSD17B1, IGF1R, NQO2 | 2.87667 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIK3CA, PIM1, SRC | 2.76508 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.7551 |
[MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | ESR1, ESR2, PPARA, PPARG | 2.58278 |
[MF] GO:0004879 | nuclear receptor activity | ESR1, ESR2, PPARA, PPARG | 2.58278 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC | 2.47217 |
[MF] GO:0099583 | None | GRM1, GRM5 | 2.46463 |
[MF] GO:0004970 | None | GRIA2, GRIA4, GRIK5 | 2.44389 |
[MF] GO:0005234 | None | GRIA2, GRIA4, GRIK5 | 2.44389 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, CYP19A1, CYP1A2, NQO2, XDH | 2.44333 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.43052 |
[MF] GO:0004930 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG | 2.37652 |
[MF] GO:0008227 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 2.37162 |
[MF] GO:0003707 | steroid hormone receptor activity | ESR1, ESR2, PPARA, PPARG | 2.32055 |
[MF] GO:0036094 | small molecule binding | ADORA1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARG, SLC1A1, SRC, XDH | 2.29084 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 | 2.2804 |
[MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.23685 |
[MF] GO:0004971 | None | GRIA2, GRIA4 | 2.23685 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC | 2.14128 |
[MF] GO:0005504 | None | FABP3, FABP4, PPARG | 2.07745 |
[MF] GO:0004435 | None | CHRM1, CHRM3, CHRM5 | 2.07745 |
[MF] GO:0030284 | estrogen receptor activity | ESR1, ESR2 | 2.06396 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 | 18.5093 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | HSP90AA1, HSP90AB1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, ESR2 | 10.0008 |
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R | 9.5334 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 | 9.488 |
Pathways in cancer_Homo sapiens_hsa05200 | HSP90AA1, HSP90AB1, PIK3CA, FLT3, MMP1, MMP2, PPARG, PIK3CB, PTGS2, MMP9, MET, IGF1R | 6.6538 |
Glutamatergic synapse_Homo sapiens_hsa04724 | GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 | 6.8187 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R | 6.3093 |
cAMP signaling pathway_Homo sapiens_hsa04024 | CHRM2, HCAR2, GRIA2, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 | 6.3329 |
Cholinergic synapse_Homo sapiens_hsa04725 | CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, PIK3CB | 5.8908 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 | 6.5741 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 | 6.2597 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 6.2077 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 | 5.6737 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CHRM2, HSP90AA1, HSP90AB1, CHRM1, PIK3CA, KDR, PIK3CB, MET, IGF1R | 4.6863 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, CDC25B, IGF1R | 4.9735 |
VEGF signaling pathway_Homo sapiens_hsa04370 | PIK3CA, SRC, KDR, PIK3CB, PTGS2 | 4.7053 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | PIK3CA, SRC, PIK3CB, ESR1, ESR2 | 4.4211 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB | 4.217 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | GRM3, GRM5, PIK3CA, GRM8, PIK3CB, GRM1 | 4.1681 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.3845 |
Prostate cancer_Homo sapiens_hsa05215 | HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, IGF1R | 4.0697 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARG, PPARA | 4.4893 |
Calcium signaling pathway_Homo sapiens_hsa04020 | CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 | 3.6914 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | GRIA2, GRM5, PTGS2, GRM1, GRIA4 | 3.8204 |
Metabolic pathways_Homo sapiens_hsa01100 | CBR1, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, CYP2A6, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH | 3.4889 |
Focal adhesion_Homo sapiens_hsa04510 | PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R | 3.4746 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B | 3.474 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R | 3.4113 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.6107 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9 | 4.1145 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5, PTGS2, PTGS1 | 3.4889 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | PIK3CA, FLT3, PIK3CB, MET | 3.4113 |
Melanoma_Homo sapiens_hsa05218 | PIK3CA, PIK3CB, MET, IGF1R | 3.3355 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, PIM1, PIK3CB | 2.8049 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | PIK3CA, PPARG, PIK3CB, IGF1R | 2.8891 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, PPARG, MMP9, MET, IGF1R | 2.8179 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | PIK3CA, SRC, PIK3CB, MET | 3.189 |
TNF signaling pathway_Homo sapiens_hsa04668 | PIK3CA, PIK3CB, PTGS2, MMP9 | 2.6859 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PIK3CA, PIK3CB, PPARA | 2.6904 |
Serotonergic synapse_Homo sapiens_hsa04726 | APP, ALOX5, PTGS2, PTGS1 | 2.667 |
Ras signaling pathway_Homo sapiens_hsa04014 | PIK3CA, KDR, PIK3CB, MET, IGF1R | 2.4638 |
Platelet activation_Homo sapiens_hsa04611 | PIK3CA, SRC, PIK3CB, PTGS1 | 2.567 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | PIK3CA, SRC, PIK3CB, ESR1 | 2.6019 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | PIK3CA, MMP2, PIK3CB, MMP9 | 2.6019 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | PIK3CA, ADORA3, ADORA1, PIK3CB | 2.5844 |
AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, PPARG, PIK3CB, IGF1R | 2.5499 |
FoxO signaling pathway_Homo sapiens_hsa04068 | PIK3CA, PIK3CB, GRM1, IGF1R | 2.4548 |
Hepatitis B_Homo sapiens_hsa05161 | PIK3CA, SRC, PIK3CB, MMP9 | 2.3634 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | PIK3CA, SRC, PIK3CB, PTGS2 | 2.2457 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | PIK3CA, ADORA3, ADORA1, PIK3CB | 2.166 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | PIK3CA, SRC, PIK3CB | 1.9462 |
Glioma_Homo sapiens_hsa05214 | PIK3CA, PIK3CB, IGF1R | 2.3785 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | PIK3CA, PIK3CB, IGF1R | 2.3812 |
ErbB signaling pathway_Homo sapiens_hsa04012 | PIK3CA, SRC, PIK3CB | 2.0776 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | PIK3CA, PIK3CB, IGF1R | 1.9003 |
Long-term depression_Homo sapiens_hsa04730 | GRIA2, GRM1, IGF1R | 2.454 |
Endocytosis_Homo sapiens_hsa04144 | SRC, KDR, MET, IGF1R | 1.6225 |
Toxoplasmosis_Homo sapiens_hsa05145 | PIK3CA, ALOX5, PIK3CB | 1.7562 |
Small cell lung cancer_Homo sapiens_hsa05222 | PIK3CA, PIK3CB, PTGS2 | 2.0847 |
Osteoclast differentiation_Homo sapiens_hsa04380 | PIK3CA, PPARG, PIK3CB | 1.6484 |
Long-term potentiation_Homo sapiens_hsa04720 | GRIA2, GRM5, GRM1 | 2.3754 |
Measles_Homo sapiens_hsa05162 | CSNK2A1, PIK3CA, PIK3CB | 1.631 |
Hepatitis C_Homo sapiens_hsa05160 | PIK3CA, PIK3CB, PPARA | 1.6455 |
Gap junction_Homo sapiens_hsa04540 | GRM5, SRC, GRM1 | 2.0707 |
Renal cell carcinoma_Homo sapiens_hsa05211 | PIK3CA, PIK3CB, MET | 2.3754 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1 | 2.3785 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, PIK3CA, PIK3CB | 1.6225 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PIK3CA, PIK3CB, PPARA | 1.5481 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | PIK3CA, PIK3CB, IGF1R | 1.6087 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 2.8416 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIK3CA, PIM1, PIK3CB | 1.5116 |
MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.2346 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3261 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.3362 |
Tuberculosis_Homo sapiens_hsa05152 | SRC | 0.3354 |
Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3482 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, PIK3CA, PIK3CB | 1.3057 |
Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.401 |
Viral carcinogenesis_Homo sapiens_hsa05203 | PIK3CA, SRC, PIK3CB | 1.2982 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | PIK3CA, SRC, PIK3CB | 1.3781 |
HTLV-I infection_Homo sapiens_hsa05166 | PIK3CA, PIK3CB | 0.5943 |
Cell cycle_Homo sapiens_hsa04110 | CDC25B | 0.442 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.4365 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.442 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET | 1.0721 |
Huntington's disease_Homo sapiens_hsa05016 | GRM5, PPARG | 0.762 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | HSP90AA1, HSP90AB1 | 0.8486 |
Apoptosis_Homo sapiens_hsa04210 | PIK3CA, PIK3CB | 0.965 |
Influenza A_Homo sapiens_hsa05164 | PIK3CA, PIK3CB | 0.8274 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.5102 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.5095 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.9666 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, PIK3CB | 0.9311 |
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PIK3CA, PIK3CB | 0.9846 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5261 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.539 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.54 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.54 |
Dopaminergic synapse_Homo sapiens_hsa04728 | GRIA2, GRIA4 | 1.0148 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.54 |
Salivary secretion_Homo sapiens_hsa04970 | CHRM3 | 0.54 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | PIK3CA, PIK3CB | 1.0658 |
Insulin secretion_Homo sapiens_hsa04911 | CHRM3 | 0.5429 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.54 |
Protein digestion and absorption_Homo sapiens_hsa04974 | SLC1A1 | 0.54 |
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | PIK3CA, PIK3CB | 1.1534 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.5487 |
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PIK3CA, PIK3CB | 1.2236 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2 | 1.2324 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | PIK3CA, PIK3CB | 1.1643 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | PIK3CA, PIK3CB | 1.1792 |
T cell receptor signaling pathway_Homo sapiens_hsa04660 | PIK3CA, PIK3CB | 1.1643 |
Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.183 |
Circadian entrainment_Homo sapiens_hsa04713 | GRIA2, GRIA4 | 1.211 |
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PIK3CA, PIK3CB | 1.1948 |
Pancreatic secretion_Homo sapiens_hsa04972 | CHRM3, CA2 | 1.2069 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, PTGS2 | 1.2236 |
Taste transduction_Homo sapiens_hsa04742 | CHRM3, GRM1 | 1.2982 |
Leishmaniasis_Homo sapiens_hsa05140 | PTGS2 | 0.5943 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.6007 |
Bile secretion_Homo sapiens_hsa04976 | CA2 | 0.5984 |
B cell receptor signaling pathway_Homo sapiens_hsa04662 | PIK3CA, PIK3CB | 1.3781 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | PIK3CA, PIK3CB | 1.3781 |
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PIK3CA, PIK3CB | 1.4165 |
Pancreatic cancer_Homo sapiens_hsa05212 | PIK3CA, PIK3CB | 1.4263 |
Gastric acid secretion_Homo sapiens_hsa04971 | CHRM3, CA2 | 1.3755 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.6287 |
Inositol phosphate metabolism_Homo sapiens_hsa00562 | PIK3CA, PIK3CB | 1.3908 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.6262 |
Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, GRIA4 | 1.419 |
Antigen processing and presentation_Homo sapiens_hsa04612 | HSP90AA1, HSP90AB1 | 1.348 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET | 1.4165 |
mTOR signaling pathway_Homo sapiens_hsa04150 | PIK3CA, PIK3CB | 1.4942 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, CYP1A2 | 1.4093 |
Colorectal cancer_Homo sapiens_hsa05210 | PIK3CA, PIK3CB | 1.4724 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | PIK3CA, PIK3CB | 1.5305 |
Endometrial cancer_Homo sapiens_hsa05213 | PIK3CA, PIK3CB | 1.581 |
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | HSP90AA1, HSP90AB1 | 1.521 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.5029 |
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | PIK3CA, PIK3CB | 1.6484 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2 | 0.7149 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | PIK3CA, PIK3CB | 1.6225 |
Malaria_Homo sapiens_hsa05144 | MET | 0.7275 |
Cocaine addiction_Homo sapiens_hsa05030 | GRM3, GRIA2 | 1.6194 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.7409 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, PIK3CB | 1.7518 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, XDH | 1.6438 |
Nicotine addiction_Homo sapiens_hsa05033 | GRIA2, GRIA4 | 1.7368 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.942 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.8066 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.9003 |
Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.8486 |
Thyroid cancer_Homo sapiens_hsa05216 | PPARG | 0.9205 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2 | 0.9205 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.1353 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.9393 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 5.3773 |