Prescription ID | TCMF4736 |
Pinyin Name | Lu Bian Bu Jiu |
Chinese Name | 鹿鞭补酒 |
English Name | Lu Bian Bu Wine |
Function Description | 腰痛, 阳痿, 早泄, 遗精, 遗精 |
Indications | Premature ejaculation disorder, Involuntary ejaculation disorder, Impotence disorder, Lumbago disorder, Sexual dysfunction, Lumbago, Premature ejaculation |
Disease ICD-11 Category |
SB08 [Premature ejaculation disorder (TM1), 早泄 (TM1)
]; SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ]; SB0B [Impotence disorder (TM1), 阳痿 (TM1) ]; SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ]; HA0Z [Sexual dysfunctions, unspecified, 性功能障碍,未特指的 ]; ME84.2Z [Low back pain, unspecified, 下腰痛,未特指的 ]; HA03.0Z [Male early ejaculation, unspecified, 男性早泄,未特指的 ]; |
Human Tissues Associated with Indication | Kidney, Bladder |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH1332 | Penis cervi | 鹿鞭 | TCMH1332 | |
TCMH2507 | Epimedium brevicornum | 淫羊藿 | TCMH2507 | AY362429 |
TCMH694 | Testis et penis canis | 狗肾 | TCMH694 | |
TCMH1389 | NA | 驴肾 | TCMH1389 | |
TCMH327 | Eleutherococcus senticosus | 刺五加 | TCMH327 | KR080437 |
TCMH1811 | Semen astragali complanati | 沙苑子 | TCMH1811 | |
TCMH193 | Psoralea corylifolia | 补骨脂 | TCMH193 | |
TCMH819 | Polygonum multiflorum | 何首乌 | TCMH819 | ITSAL419-14 |
TCMH2202 | Schisandra chinensis | 五味子 | TCMH2202 | ITSAM2867-14 |
TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
TCMH2149 | Cuscuta australis | 菟丝子 | TCMH2149 | ITSAP4209-14 |
TCMH451 | Rehmannia glutinosa | 地黄 | TCMH451 | ITSAH4578-14 |
TCMH1186 | Lycium chinense | 枸杞子 | TCMH1186 | ITSAO4545-14 |
TCMH865 | Carthamus tinctorius | 红花 | TCMH865 | ITSAI2447-14 |
TCMH241 | Plantago asiatica | 车前子 | TCMH241 | ITSAB3641-14 |
TCMH784 | Syngnathus sp. | 海龙 | TCMH784 | FBERM005-06 |
TCMH787 | Hippocampus | 海马 | TCMH787 | |
TCMH611 | Rubus idaeus | 覆盆子 | TCMH611 | ITSAE336-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT151 | PRKCA | Protein kinase C alpha | Kinase | P17252 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
TCMT164 | PTGS1 | Cyclooxygenase-1 | Oxidoreductase | P23219 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT189 | DUSP3 | Dual specificity protein phosphatase 3 | Hydrolase | P51452 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
TCMT237 | SLC5A1 | Sodium/glucose cotransporter 1 | Transporter | P13866 |
TCMT238 | SLC5A2 | Sodium/glucose cotransporter 2 | Transporter | P31639 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT290 | CHRM5 | Muscarinic acetylcholine receptor M5 | GPCR | P08912 |
TCMT291 | CHRM3 | Muscarinic acetylcholine receptor M3 | GPCR | P20309 |
TCMT292 | CHRM1 | Muscarinic acetylcholine receptor M1 | GPCR | P11229 |
TCMT293 | CHRM2 | Muscarinic acetylcholine receptor M2 | GPCR | P08172 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
TCMT30 | PTGS2 | Cyclooxygenase-2 | Oxidoreductase | P35354 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT318 | HKDC1 | Putative hexokinase HKDC1 | Transferase | Q2TB90 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT327 | TRPV1 | Vanilloid receptor | Ion channel | Q8NER1 |
TCMT329 | NQO2 | Quinone reductase 2 | Oxidoreductase | P16083 |
TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
TCMT354 | AURKA | Serine/threonine-protein kinase Aurora-A | Kinase | O14965 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT377 | INSR | Insulin receptor | Kinase | P06213 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT418 | EPHB4 | Ephrin type-B receptor 4 | Kinase | P54760 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT423 | EGFR | Epidermal growth factor receptor erbB1 | Kinase | P00533 |
TCMT436 | NUAK1 | NUAK family SNF1-like kinase 1 | Kinase | O60285 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
TCMT457 | FLT4 | Vascular endothelial growth factor receptor 3 | Kinase | P35916 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT502 | TEK | Tyrosine-protein kinase TIE-2 | Kinase | Q02763 |
TCMT536 | PDGFRB | Platelet-derived growth factor receptor beta | Kinase | P09619 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT599 | UBE2N | Ubiquitin-conjugating enzyme E2 N | Transferase | P61088 |
TCMT613 | NR3C1 | Glucocorticoid receptor | Nuclear receptor | P04150 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT619 | HSP90AA1 | Heat shock protein HSP 90-alpha | Unclassified | P07900 |
TCMT624 | HSP90AB1 | Heat shock protein HSP 90-beta | Unclassified | P08238 |
TCMT626 | BRAF | Serine/threonine-protein kinase B-raf | Kinase | P15056 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT67 | PPARG | Peroxisome proliferator-activated receptor gamma | Nuclear receptor | P37231 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT721 | HSPA1A | Heat shock 70 kDa protein 1 | Unclassified | P0DMV8 |
TCMT729 | PIK3CA | PI3-kinase p110-alpha subunit | Transferase | P42336 |
TCMT730 | PIK3CB | PI3-kinase p110-beta subunit | Transferase | P42338 |
TCMT739 | GPR35 | G-protein coupled receptor 35 | GPCR | Q9HC97 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT753 | SMAD3 | Mothers against decapentaplegic homolog 3 | Unclassified | P84022 |
TCMT755 | PLK4 | Serine/threonine-protein kinase PLK4 | Kinase | O00444 |
TCMT756 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Kinase | P41279 |
TCMT759 | SAE1 | SUMO-activating enzyme subunit 1 | Unclassified | Q9UBE0 |
TCMT771 | ATR | Serine-protein kinase ATR | Kinase | Q13535 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT81 | ALOX12 | Arachidonate 12-lipoxygenase | Oxidoreductase | P18054 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT847 | SLC5A4 | Low affinity sodium-glucose cotransporter | Transporter | Q9NY91 |
TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1179 | Escherichia coli ATCC 8739 |
TCMT1180 | Human herpesvirus 2 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1182 | Streptococcus sanguinis |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1191 | Bacillus megaterium |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1211 | Fusobacterium nucleatum |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1217 | Bacillus anthracis |
TCMT1218 | Staphylococcus aureus |
TCMT1221 | Human herpesvirus 4 |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1227 | Streptococcus |
TCMT1229 | Enterococcus faecalis |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1236 | Mycobacterium bovis |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1250 | Vesicular stomatitis virus |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1260 | Streptococcus agalactiae |
TCMT1282 | Colletotrichum orbiculare |
TCMT1284 | Penicillium expansum |
TCMT1286 | Bacillus cereus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1319 | Corynebacterium xerosis |
TCMT1322 | Streptococcus mitis |
TCMT1323 | Corynebacterium pseudodiphtheriticum |
TCMT1324 | Corynebacterium diphtheriae |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1393 | Vibrio sp. |
TCMT1410 | Listeria monocytogenes |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1444 | Fusarium oxysporum |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, TRPV1 | 15.214 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PTGS1, PTGS2, SMAD3, SRC, TEK, TRPV1, XDH | 11.4268 |
[BP] GO:0010033 | response to organic substance | AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PPARA, PPARG, PRKCA, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 10.9963 |
[BP] GO:0019369 | arachidonic acid metabolic process | ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 10.5048 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, HSPA1A, PIK3CA, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR, XDH | 9.60143 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 9.54092 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2 | 9.44207 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, HSD17B2, HSP90AB1, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PPARG, PTGS2, RORC, SRC, TEK, TRPV1, TYR | 9.44207 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH | 9.43071 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH | 9.43071 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 9.3625 |
[BP] GO:0042221 | response to chemical | AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PPARG, PRKCA, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 9.34172 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 9.34172 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH | 8.80972 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, ALOX12, APP, CDC25B, CHRM1, CSNK2A1, CYP1B1, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PPARG, PRKCA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH | 8.78876 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 8.72983 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 8.70328 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PPARG, PTGS1, PTGS2, TYR, XDH | 8.53548 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 8.53548 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 8.22053 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG, PTGS1, PTGS2 | 8.09871 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK | 8.08629 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK | 7.95334 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 | 7.95334 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 7.86401 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR | 7.7941 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 7.7732 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TYR, XDH | 7.67559 |
[BP] GO:0014070 | response to organic cyclic compound | APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, PTGS2, RORC, SRC, TEK, TRPV1, TYR | 7.57951 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARG, PTGS2, RORC, SMAD3, SRC, TRPV1 | 7.57951 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK | 7.29024 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK | 7.27764 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH | 7.19255 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH | 7.16949 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARA, PPARG, PTGS2, SMAD3, SRC, TEK, TRPV1 | 7.12239 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PPARG, PTGS2, RORC, SMAD3, SRC, TRPV1 | 7.0576 |
[BP] GO:1904407 | positive regulation of nitric oxide metabolic process | EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 | 6.96475 |
[BP] GO:0045429 | positive regulation of nitric oxide biosynthetic process | EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 | 6.96475 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, INSR, MET, PIK3CA, PIK3CB, PPARG, SMAD3, SRC, TRPV1 | 6.91651 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CB, PPARA, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1 | 6.87599 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS2, RORC, SMAD3, SRC, TEK, TYR | 6.85831 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.78746 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 6.78389 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 6.67778 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 6.59874 |
[BP] GO:0009725 | response to hormone | AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, NR3C1, PPARA, PPARG, PTGS2, SRC, TEK, TRPV1 | 6.59672 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, HSP90AB1, NQO2, PTGS1, RORC | 6.58555 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, PIK3CA, PPARA, PPARG, SMAD3, SRC, TEK, TYR | 6.57643 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 6.4832 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK | 6.4832 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PPARG, PRKCA, PTGS2, SMAD3, SRC, TEK | 6.46744 |
[BP] GO:0007197 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.42883 |
[BP] GO:0080134 | regulation of response to stress | ADORA1, ALOX12, APP, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 6.42326 |
[BP] GO:0071407 | cellular response to organic cyclic compound | APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, PTGS2, RORC, SRC, TRPV1 | 6.42184 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, ALOX15, APP, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 6.37249 |
[BP] GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 | 6.37249 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, ALOX12, APP, CHRM1, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PPARG, PRKCA, PTGS2, SMAD3, SRC, TEK | 6.37134 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, ALOX15, APP, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 6.32501 |
[BP] GO:2000379 | positive regulation of reactive oxygen species metabolic process | EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1, XDH | 6.14717 |
[BP] GO:0033993 | response to lipid | AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, NR3C1, PPARG, PTGS2, RORC, SRC, TYR | 6.14004 |
[BP] GO:0045428 | regulation of nitric oxide biosynthetic process | EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 | 6.14004 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PPARG, PRKCA, PTGS2, SMAD3, SRC, TEK | 6.12907 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 | 6.08064 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PPARG, PTGS2, RORC, SMAD3, SRC, TEK, TYR | 6.07545 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK | 6.06823 |
[BP] GO:0007207 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.06262 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC | 6.06262 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK | 6.01604 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 | 6.01388 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APP, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PPARG, PTGS2, RORC, SRC, TRPV1 | 5.90741 |
[BP] GO:0032787 | None | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG, PTGS1, PTGS2 | 5.89373 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK | 5.89373 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC5A1, SMAD3, SRC, TEK, TRPV1, TYR | 5.89373 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7, CA9 | 5.8833 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 5.85786 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1 | 5.8257 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.78737 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.78341 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.78341 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, PTGS2, SMAD3, SRC, TEK, TRPV1, TYR | 5.68243 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PPARG, PRKCA, PTGS2, SMAD3, SRC, TEK | 5.67599 |
[BP] GO:0065009 | regulation of molecular function | ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH | 5.67104 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 | 5.64521 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2, PRKCA | 5.62172 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.47095 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH | 5.46548 |
[BP] GO:0030335 | positive regulation of cell migration | ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK | 5.42864 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PPARG, PTGS2, RORC, SRC, TEK | 5.42107 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 5.40758 |
[BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, SRC, TEK | 5.40516 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 5.39258 |
[BP] GO:2000377 | regulation of reactive oxygen species metabolic process | CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1, XDH | 5.37029 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, ALOX12, APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, PPARG, SMAD3, TRPV1 | 5.36688 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH | 5.35639 |
[BP] GO:0050790 | regulation of catalytic activity | ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.35509 |
[BP] GO:0051049 | regulation of transport | ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CHRM1, CYP19A1, EGFR, GPR35, HCAR2, HSP90AB1, HSPA1A, INSR, MMP9, PIK3CB, PPARA, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TRPV1 | 5.32613 |
[BP] GO:2000147 | positive regulation of cell motility | ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK | 5.30029 |
[BP] GO:1903426 | None | EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 | 5.21625 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR | 5.19275 |
[BP] GO:0051272 | positive regulation of cellular component movement | ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK | 5.17462 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APP, EGFR, FABP3, FLT3, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PTGS2, SRC, TEK, TRPV1, TYR | 5.15858 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ADORA1, ALOX15, APP, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.14223 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH | 5.14223 |
[BP] GO:0048583 | regulation of response to stimulus | ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.14063 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH | 5.11001 |
[BP] GO:0031399 | regulation of protein modification process | ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH | 5.10249 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, ALOX15, APP, AURKB, CDC25B, EGFR, ESR1, ESR2, FABP3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 5.06829 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK | 5.06069 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH | 5.05559 |
[BP] GO:0040017 | positive regulation of locomotion | ALOX12, APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK | 5.02974 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH | 5.01807 |
[BP] GO:0051338 | regulation of transferase activity | ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, PIK3CA, PIK3CB, PPARG, PTPN1, SRC, TEK | 4.96475 |
[BP] GO:0009966 | regulation of signal transduction | ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 4.94656 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ADORA1, ALOX15, APP, CDC25B, EGFR, ESR1, FLT3, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 4.93706 |
[BP] GO:0016310 | phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK | 4.87258 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, FABP3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 4.86183 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, ALOX15, APP, EGFR, FLT3, INSR, KDR, PIK3CB, PRKCA, PTPN1, SRC, TEK, XDH | 4.82145 |
[BP] GO:0007165 | signal transduction | ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 | 4.81377 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, SRC | 4.8022 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APP, EGFR, FABP3, FLT3, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PTGS2, SRC, TEK, TRPV1, TYR | 4.76324 |
[BP] GO:0043408 | regulation of MAPK cascade | ADORA1, ALOX15, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PIK3CB, PRKCA, PTPN1, SRC, TEK, XDH | 4.74086 |
[BP] GO:1901652 | response to peptide | AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, PPARG, PTGS2, SRC, TEK, TRPV1 | 4.73763 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 4.67994 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH | 4.66909 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK | 4.6635 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, AXL, CYP1B1, EGFR, HSP90AB1, KDR, NR3C1, PTGS2, SRC, TRPV1 | 4.63672 |
[BP] GO:0001775 | cell activation | ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PIK3CA, PIK3CB, PRKCA, RORC, SMAD3, SRC, TRPV1 | 4.62364 |
[BP] GO:0051239 | regulation of multicellular organismal process | ADORA1, ADORA3, ALOX12, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, ESR1, GPR35, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIM1, PPARG, PRKCA, PTGS2, SMAD3, SRC, TEK, TRPV1, XDH | 4.5936 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR | 4.53782 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH | 4.51981 |
[BP] GO:0046456 | icosanoid biosynthetic process | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 4.35836 |
[BP] GO:0006950 | response to stress | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSP90AA1, HSP90AB1, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1 | 4.29884 |
[BP] GO:0007213 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.29766 |
[BP] GO:0019372 | lipoxygenase pathway | ALOX12, ALOX15, ALOX5, PTGS2 | 4.29766 |
[BP] GO:0048010 | vascular endothelial growth factor receptor signaling pathway | AXL, HSP90AA1, KDR, PIK3CA, PIK3CB, SRC | 4.292 |
[BP] GO:0031347 | regulation of defense response | ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK | 4.28377 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APP, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARG, PTGS2, SMAD3, SRC, TRPV1 | 4.25984 |
[BP] GO:0038128 | None | EGFR, HSP90AA1, PIK3CA, PRKCA, SRC | 4.25984 |
[BP] GO:0030522 | intracellular receptor signaling pathway | ESR1, ESR2, NR3C1, PIM1, PPARA, PPARG, RORC, SRC | 4.24279 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1 | 4.20777 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, PPARG, PTGS2, SRC, TEK | 4.15288 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, PRKCA, PTGS2, SRC, TEK | 4.10773 |
[BP] GO:0032268 | regulation of cellular protein metabolic process | ADORA1, ALOX15, APP, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 4.08583 |
[BP] GO:0044093 | positive regulation of molecular function | ADORA1, APP, AURKB, CDC25B, EGFR, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PPARG, PTPN1, SMAD3, SRC, TEK, XDH | 4.06281 |
[BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 | 4.04843 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARG, TRPV1 | 4.04428 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR | 4.0192 |
[BP] GO:0043401 | steroid hormone mediated signaling pathway | ESR1, ESR2, NR3C1, PPARA, PPARG, RORC, SRC | 4.01312 |
[BP] GO:0044057 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, EGFR, GPR35, HCAR2, PRKCA, PTGS2, SMAD3, TRPV1 | 3.98474 |
[BP] GO:0031401 | positive regulation of protein modification process | ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH | 3.98128 |
[BP] GO:0048585 | negative regulation of response to stimulus | ADORA1, ALOX12, ALOX15, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 3.95505 |
[BP] GO:0051050 | positive regulation of transport | ACHE, ADORA1, APP, AXL, CA2, CHRM1, CYP19A1, EGFR, HCAR2, HSP90AB1, INSR, PPARG, PTGS2, SMAD3, SRC, TRPV1 | 3.94623 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC | 3.94623 |
[BP] GO:0006082 | organic acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR | 3.93768 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 3.92916 |
[BP] GO:0042493 | response to drug | AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HSP90AB1, KDR, NR3C1, PPARG, PTGS2, SRC, TRPV1 | 3.92916 |
[BP] GO:0043549 | regulation of kinase activity | ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSP90AB1, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 3.92916 |
[BP] GO:0038083 | peptidyl-tyrosine autophosphorylation | EGFR, IGF1R, INSR, KDR, SRC | 3.90335 |
[BP] GO:2001300 | lipoxin metabolic process | ALOX12, ALOX15, ALOX5 | 3.9023 |
[BP] GO:0070372 | regulation of ERK1 and ERK2 cascade | ALOX15, APP, DUSP3, EGFR, KDR, PRKCA, PTPN1, SRC, TEK | 3.8391 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 3.83402 |
[BP] GO:0051972 | regulation of telomerase activity | AURKB, HSP90AA1, HSP90AB1, PPARG, SRC | 3.83402 |
[BP] GO:0002682 | regulation of immune system process | ADORA1, ALOX15, APP, AXL, CA2, CYP19A1, DUSP3, ESR1, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PIK3CA, PIK3CB, PPARG, PRKCA, PTPN1, SMAD3, SRC | 3.81143 |
[BP] GO:0051240 | positive regulation of multicellular organismal process | ALOX12, APP, AXL, CA2, CHRM3, CYP1B1, EGFR, HCAR2, HSPA1A, KDR, MET, MMP9, PIM1, PPARG, PRKCA, PTGS2, SMAD3, SRC, TEK, TRPV1 | 3.78797 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH | 3.77382 |
[BP] GO:0095500 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.72587 |
[BP] GO:1903831 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.72587 |
[BP] GO:0071248 | cellular response to metal ion | ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 | 3.70312 |
[BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.69825 |
[BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.69825 |
[BP] GO:0045787 | positive regulation of cell cycle | APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSP90AB1, INSR, PRKCA, SRC | 3.69825 |
[BP] GO:0030155 | regulation of cell adhesion | ALOX12, ALOX15, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, SMAD3, SRC, TEK | 3.67841 |
[BP] GO:0043085 | positive regulation of catalytic activity | ADORA1, APP, AURKB, CDC25B, EGFR, ESR1, FLT3, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIK3CA, PIK3CB, PPARG, PTPN1, SMAD3, SRC, TEK, XDH | 3.67841 |
[BP] GO:0010632 | regulation of epithelial cell migration | KDR, MET, MMP9, PPARG, PRKCA, PTGS2, SRC, TEK | 3.67691 |
[BP] GO:0032101 | regulation of response to external stimulus | ADORA1, ALOX12, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, PPARA, PPARG, PRKCA, PTGS2, SMAD3, TEK | 3.66681 |
[BP] GO:0070482 | response to oxygen levels | ADORA1, CYP1A1, MMP2, PPARA, PPARG, PTGS2, SMAD3, SRC, TEK | 3.66681 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.66681 |
[BP] GO:0045859 | regulation of protein kinase activity | ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSP90AB1, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC | 3.63578 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, CA2, CA7, EGFR, HCAR2, KDR, PIK3CB, PTGS2, SRC, TRPV1 | 3.6061 |
[BP] GO:0009894 | regulation of catabolic process | ADORA1, CSNK2A1, EGFR, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PTPN1, SMAD3 | 3.59984 |
[BP] GO:0003018 | None | ADORA1, CHRM1, CHRM3, EGFR, PTGS2, SRC, TEK | 3.59899 |
[BP] GO:0051347 | positive regulation of transferase activity | ADORA1, AURKB, CDC25B, EGFR, FLT3, HSP90AA1, HSP90AB1, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 3.58852 |
[BP] GO:0050727 | regulation of inflammatory response | ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PPARG, PTGS2, SMAD3, TEK | 3.55225 |
[BP] GO:0051701 | interaction with host | AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC | 3.54903 |
[BP] GO:0051246 | regulation of protein metabolic process | ADORA1, ALOX15, APP, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 3.49397 |
[BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, PPARG, PTGS2, SRC, TRPV1 | 3.4904 |
[BP] GO:0007271 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.4796 |
[BP] GO:0009892 | negative regulation of metabolic process | ADORA1, APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, FABP4, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH | 3.47611 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR | 3.43278 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC | 3.41441 |
[BP] GO:0009755 | hormone-mediated signaling pathway | ESR1, ESR2, NR3C1, PPARA, PPARG, RORC, SRC | 3.41219 |
[BP] GO:0010038 | response to metal ion | ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 | 3.38539 |
[BP] GO:0006636 | unsaturated fatty acid biosynthetic process | ALOX12, ALOX15, PTGS1, PTGS2 | 3.3711 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, PTGS2, SRC | 3.35912 |
[BP] GO:0030258 | lipid modification | ALOX12, CYP1A1, CYP3A4, EGFR, MET, PIK3CA, PIK3CB, PPARG | 3.34063 |
[BP] GO:0071241 | cellular response to inorganic substance | ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 | 3.34063 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR | 3.34063 |
[BP] GO:0071363 | cellular response to growth factor stimulus | APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 | 3.31989 |
[BP] GO:0006940 | None | ADORA1, CHRM1, CHRM2, CHRM3, PTGS2 | 3.31185 |
[BP] GO:0050728 | negative regulation of inflammatory response | ADORA1, CYP19A1, PPARA, PPARG, SMAD3, TEK | 3.27789 |
[BP] GO:1901654 | None | AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, PPARG, SRC | 3.25123 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.24309 |
[BP] GO:0009611 | response to wounding | ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 | 3.23846 |
[BP] GO:1901699 | cellular response to nitrogen compound | AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, PPARG, PTGS2, SRC, TRPV1 | 3.22759 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, EGFR, HSPA1A | 3.22759 |
[BP] GO:0048871 | multicellular organismal homeostasis | ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 | 3.22291 |
[BP] GO:0001525 | angiogenesis | CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK | 3.19619 |
[BP] GO:0043405 | regulation of MAP kinase activity | ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC | 3.19436 |
[BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, APP, CA2, CA7, EGFR, PTGS2 | 3.1684 |
[BP] GO:0051098 | regulation of binding | APP, AURKB, HSP90AB1, MET, MMP9, PPARA, PPARG, SMAD3, SRC | 3.1684 |
[BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 3.16701 |
[BP] GO:0080135 | regulation of cellular response to stress | APP, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, XDH | 3.14225 |
[BP] GO:0010648 | negative regulation of cell communication | ACHE, ADORA1, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PPARG, PTGS2, PTPN1, SMAD3, SRC, XDH | 3.13261 |
[BP] GO:0019371 | None | CBR1, PTGS1, PTGS2 | 3.12926 |
[BP] GO:0009895 | negative regulation of catabolic process | ADORA1, EGFR, HCAR2, HSP90AB1, MET, PIK3CA, PPARA, SMAD3 | 3.12615 |
[BP] GO:1903725 | regulation of phospholipid metabolic process | CHRM5, FABP3, FLT3, SRC, TEK | 3.12343 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARG, TRPV1 | 3.12242 |
[BP] GO:0023057 | negative regulation of signaling | ACHE, ADORA1, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PPARG, PTGS2, PTPN1, SMAD3, SRC, XDH | 3.12242 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR | 3.10351 |
[BP] GO:0033674 | positive regulation of kinase activity | ADORA1, CDC25B, EGFR, FLT3, HSP90AB1, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 3.10333 |
[BP] GO:0007346 | regulation of mitotic cell cycle | APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSP90AA1, HSPA1A, INSR, PIM1, PRKCA, SMAD3 | 3.08958 |
[BP] GO:0036293 | response to decreased oxygen levels | ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 3.08958 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 3.08958 |
[BP] GO:0048608 | reproductive structure development | AXL, CYP19A1, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, SRC | 3.05811 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 | 3.05811 |
[BP] GO:0048660 | regulation of smooth muscle cell proliferation | AKR1B1, EGFR, MMP2, MMP9, PPARG, PTGS2 | 3.05617 |
[BP] GO:0051726 | regulation of cell cycle | APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIM1, PRKCA, PTGS2, SMAD3, SRC | 3.05617 |
[BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 3.05271 |
[BP] GO:0051130 | positive regulation of cellular component organization | ALOX15, APP, AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, SMAD3, SRC, TEK | 3.03597 |
[BP] GO:0042738 | exogenous drug catabolic process | CYP1A2, CYP2A6, CYP3A4 | 3.03284 |
[BP] GO:0007193 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 | 3.03284 |
[BP] GO:0031100 | animal organ regeneration | AXL, CSNK2A1, EGFR, FLT3, PPARG | 3.03284 |
[BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, EGFR, MMP2, MMP9, PTGS2 | 3.03284 |
[BP] GO:1900182 | positive regulation of protein localization to nucleus | APP, EGFR, HSP90AB1, PTGS2, SMAD3, SRC | 3.02776 |
[BP] GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ALOX15, APP, EGFR, KDR, PRKCA, SRC, TEK | 3.01941 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR, XDH | 2.99804 |
[BP] GO:0043434 | None | FABP3, INSR, PPARA, PPARG, PTGS2, SRC, TEK, TRPV1 | 2.9835 |
[BP] GO:0070848 | response to growth factor | APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 | 2.97364 |
[BP] GO:2001301 | lipoxin biosynthetic process | ALOX12, ALOX15 | 2.9717 |
[BP] GO:2001302 | lipoxin A4 metabolic process | ALOX12, ALOX15 | 2.9717 |
[BP] GO:2001303 | lipoxin A4 biosynthetic process | ALOX12, ALOX15 | 2.9717 |
[BP] GO:1901570 | None | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 2.94324 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.94134 |
[BP] GO:0048511 | rhythmic process | AXL, CSNK2A1, EGFR, ESR1, PPARA, PPARG, RORC, SRC | 2.93311 |
[BP] GO:0003013 | None | ADORA1, CHRM1, CHRM3, EGFR, PTGS2, SRC, TEK | 2.9295 |
[BP] GO:0043393 | regulation of protein binding | APP, AURKB, HSP90AB1, MET, MMP9, PPARA, SRC | 2.9295 |
[BP] GO:1901655 | None | AKR1B1, EGFR, NR3C1, PPARG, SRC | 2.92363 |
[BP] GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | CSNK2A1, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH | 2.91853 |
[BP] GO:0090087 | None | ACHE, ADORA1, APP, CA2, CHRM1, EGFR, HCAR2, HSP90AB1, PRKCA, PTGS2, PTPN1, SMAD3, SRC | 2.91844 |
[BP] GO:0033273 | response to vitamin | CYP1A1, EGFR, PPARG, PTGS2, TYR | 2.90163 |
[BP] GO:0009891 | positive regulation of biosynthetic process | APP, AURKB, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, PTGS2, RORC, SMAD3, SRC, TRPV1 | 2.8874 |
[BP] GO:0038127 | None | EGFR, HSP90AA1, PIK3CA, PRKCA, SRC | 2.87993 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.85244 |
[BP] GO:0080090 | regulation of primary metabolic process | ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.84598 |
[BP] GO:0051054 | positive regulation of DNA metabolic process | AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, SRC | 2.83658 |
[BP] GO:0044089 | positive regulation of cellular component biogenesis | ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, SMAD3, SRC, TEK | 2.83658 |
[BP] GO:0010595 | positive regulation of endothelial cell migration | KDR, MET, PRKCA, PTGS2, TEK | 2.83614 |
[BP] GO:0051052 | regulation of DNA metabolic process | AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PIK3CA, PPARG, SRC | 2.82061 |
[BP] GO:0045931 | positive regulation of mitotic cell cycle | APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA | 2.81702 |
[BP] GO:0051128 | regulation of cellular component organization | ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, ESR1, ESR2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PPARG, PTPN1, SMAD3, SRC, TEK | 2.81249 |
[BP] GO:0003006 | developmental process involved in reproduction | AXL, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, PTGS2, SRC | 2.80261 |
[BP] GO:0007200 | None | CHRM1, CHRM2, CHRM3, CHRM5, ESR1 | 2.79351 |
[BP] GO:1903727 | positive regulation of phospholipid metabolic process | FABP3, FLT3, SRC, TEK | 2.7908 |
[BP] GO:0014074 | response to purine-containing compound | APP, PPARG, PTGS2, TEK, TRPV1, TYR | 2.7908 |
[BP] GO:0030100 | regulation of endocytosis | ALOX15, APP, AXL, PIK3CB, PPARG, PTPN1, SRC | 2.77349 |
[BP] GO:0008217 | None | ADORA1, PPARA, PPARG, PTGS1, PTGS2, SMAD3 | 2.74598 |
[BP] GO:0009266 | None | ADORA1, HSP90AA1, HSPA1A, PPARG, PTGS2, TRPV1 | 2.7321 |
[BP] GO:0071900 | regulation of protein serine/threonine kinase activity | ADORA1, DUSP3, EGFR, FLT3, HSP90AB1, IGF1R, INSR, PIK3CB, PTPN1, SRC | 2.72961 |
[BP] GO:0046486 | glycerolipid metabolic process | ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB | 2.70451 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, EGFR, HCAR2, PIK3CB, PTGS2 | 2.69929 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.69929 |
[BP] GO:0051131 | None | HSP90AA1, HSP90AB1, HSPA1A | 2.69929 |
[BP] GO:0019222 | regulation of metabolic process | ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.6953 |
[BP] GO:0045766 | positive regulation of angiogenesis | ALOX12, CYP1B1, KDR, PRKCA, PTGS2, TEK | 2.68016 |
[BP] GO:0090257 | None | ADORA1, CHRM1, CHRM2, CHRM3, PRKCA, PTGS2, SMAD3 | 2.68016 |
[BP] GO:0045860 | positive regulation of protein kinase activity | ADORA1, CDC25B, EGFR, FLT3, HSP90AB1, INSR, PIK3CA, PIK3CB, PTPN1, SRC | 2.66365 |
[BP] GO:0010594 | regulation of endothelial cell migration | KDR, MET, PPARG, PRKCA, PTGS2, TEK | 2.65337 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH | 2.64563 |
[BP] GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | HSPA1A, MMP9, PTGS2, PTPN1, SRC | 2.64073 |
[BP] GO:0018193 | peptidyl-amino acid modification | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCA, SRC, TEK | 2.61728 |
[BP] GO:0007186 | G-protein coupled receptor signaling pathway | ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GPR35, HCAR2, INSR, PIK3CA, PIK3CB, PPARG, SRC | 2.61728 |
[BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, NR3C1, PPARA, PPARG, RORC | 2.59887 |
[BP] GO:2000116 | regulation of cysteine-type endopeptidase activity | CSNK2A1, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH | 2.59679 |
[BP] GO:0042307 | positive regulation of protein import into nucleus | APP, EGFR, HSP90AB1, PTGS2, SMAD3 | 2.58167 |
[BP] GO:1901617 | organic hydroxy compound biosynthetic process | AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR | 2.57222 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.56919 |
[BP] GO:1904591 | positive regulation of protein import | APP, EGFR, HSP90AB1, PTGS2, SMAD3 | 2.54879 |
[BP] GO:0048732 | gland development | CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR | 2.53927 |
[BP] GO:1901342 | regulation of vasculature development | ALOX12, CYP1B1, KDR, PPARG, PRKCA, PTGS2, TEK, XDH | 2.53487 |
[BP] GO:0051828 | entry into other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.53487 |
[BP] GO:0051806 | entry into cell of other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.53487 |
[BP] GO:0030260 | entry into host cell | AXL, EGFR, HSPA1A, MET, SRC | 2.53487 |
[BP] GO:0044409 | entry into host | AXL, EGFR, HSPA1A, MET, SRC | 2.53487 |
[BP] GO:0040008 | regulation of growth | ALOX12, APP, CSNK2A1, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, PPARG, SMAD3 | 2.51828 |
[BP] GO:0031328 | positive regulation of cellular biosynthetic process | APP, AURKB, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, MET, NR3C1, PPARA, PPARG, PTGS2, RORC, SMAD3, SRC, TRPV1 | 2.51774 |
[BP] GO:0072593 | reactive oxygen species metabolic process | ALOX12, CYP1A1, CYP1A2, CYP1B1, EGFR | 2.51774 |
[BP] GO:0001952 | regulation of cell-matrix adhesion | KDR, PIK3CB, SMAD3, SRC, TEK | 2.49873 |
[BP] GO:0006954 | inflammatory response | ADORA1, ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 | 2.49873 |
[BP] GO:0046903 | None | ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, HSP90AA1, HSP90AB1, HSPA1A, MMP9, TRPV1, XDH | 2.48927 |
[BP] GO:0044283 | None | AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, PTGS1, PTGS2 | 2.47147 |
[BP] GO:0031348 | negative regulation of defense response | ADORA1, CYP19A1, PPARA, PPARG, SMAD3, TEK | 2.46628 |
[BP] GO:2000278 | regulation of DNA biosynthetic process | AURKB, HSP90AA1, HSP90AB1, PPARG, SRC | 2.4653 |
[BP] GO:0051893 | regulation of focal adhesion assembly | KDR, SMAD3, SRC, TEK | 2.46055 |
[BP] GO:0090109 | regulation of cell-substrate junction assembly | KDR, SMAD3, SRC, TEK | 2.46055 |
[BP] GO:0050801 | ion homeostasis | APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, PIK3CB, SMAD3, TRPV1 | 2.43944 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC | 2.43199 |
[BP] GO:0060255 | regulation of macromolecule metabolic process | ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.42812 |
[BP] GO:1904018 | positive regulation of vasculature development | ALOX12, CYP1B1, KDR, PRKCA, PTGS2, TEK | 2.42036 |
[BP] GO:0031323 | regulation of cellular metabolic process | ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.39934 |
[BP] GO:0022414 | reproductive process | AKR1B1, APP, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, HSD17B2, HSP90AB1, INSR, MMP2, MMP9, PPARG, PTGS2, SRC | 2.3935 |
[BP] GO:0031324 | negative regulation of cellular metabolic process | APP, AURKB, CSNK2A1, DUSP3, ESR1, ESR2, FABP4, HSP90AB1, HSPA1A, IGF1R, MET, MMP9, NR3C1, PIK3CA, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH | 2.39154 |
[BP] GO:0071498 | cellular response to fluid shear stress | CA2, PTGS2, SRC | 2.38982 |
[BP] GO:0071902 | positive regulation of protein serine/threonine kinase activity | ADORA1, EGFR, FLT3, HSP90AB1, INSR, PIK3CB, PTPN1, SRC | 2.38723 |
[BP] GO:0030168 | platelet activation | AXL, PIK3CA, PIK3CB, PRKCA, SRC | 2.38624 |
[BP] GO:1903391 | regulation of adherens junction organization | KDR, SMAD3, SRC, TEK | 2.38498 |
[BP] GO:0050793 | regulation of developmental process | ALOX12, APP, AXL, CA2, CYP1B1, EGFR, ESR1, HSP90AB1, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.37006 |
[BP] GO:0071396 | cellular response to lipid | AXL, EGFR, ESR1, FLT3, NR3C1, PPARG, RORC, SRC | 2.35079 |
[BP] GO:0043406 | positive regulation of MAP kinase activity | ADORA1, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC | 2.34199 |
[BP] GO:0035428 | None | SLC5A1, SLC5A2, SLC5A4 | 2.34092 |
[BP] GO:1904659 | None | SLC5A1, SLC5A2, SLC5A4 | 2.34092 |
[BP] GO:1905950 | None | SLC5A1, SLC5A2, SLC5A4 | 2.34092 |
[BP] GO:0030520 | intracellular estrogen receptor signaling pathway | ESR1, ESR2, SRC | 2.34092 |
[BP] GO:0001503 | ossification | ALOX15, EGFR, MMP2, MMP9, TEK | 2.32714 |
[BP] GO:1905323 | None | HSP90AA1, HSP90AB1 | 2.32714 |
[BP] GO:0033031 | positive regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.32714 |
[BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.32714 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.32714 |
[BP] GO:0051172 | None | APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, FABP4, HSP90AB1, HSPA1A, IGF1R, MMP9, NR3C1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH | 2.31931 |
[BP] GO:0019229 | None | CHRM1, CHRM3, EGFR, PTGS2 | 2.31786 |
[BP] GO:0003008 | None | ADORA1, AKR1B1, APP, CHRM1, CHRM3, CHRM5, CYP1B1, EGFR, INSR, PIK3CA, PTGS2, SLC5A1, SRC, TEK, TRPV1, TYR | 2.31162 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.29558 |
[BP] GO:0010810 | regulation of cell-substrate adhesion | ALOX15, KDR, PIK3CB, SMAD3, SRC, TEK | 2.28376 |
[BP] GO:0051894 | None | KDR, SMAD3, TEK | 2.24474 |
[BP] GO:0035902 | response to immobilization stress | CYP1A1, CYP1A2, PPARG | 2.24474 |
[BP] GO:0061900 | None | APP, EGFR, TRPV1 | 2.24474 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.24474 |
[BP] GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | APP, AURKB, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, NR3C1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC | 2.24262 |
[BP] GO:0034097 | response to cytokine | ALOX15, AXL, FABP4, FLT3, HSP90AB1, PRKCA, PTGS2, SRC, TRPV1 | 2.24262 |
[BP] GO:0007584 | response to nutrient | CYP1A1, EGFR, PPARG, PTGS2, TRPV1, TYR | 2.22912 |
[BP] GO:0051094 | positive regulation of developmental process | ALOX12, APP, AXL, CA2, CYP1B1, HSP90AB1, INSR, KDR, PIM1, PPARG, PRKCA, PTGS2, SMAD3, SRC, TEK | 2.22678 |
[BP] GO:0051222 | positive regulation of protein transport | ACHE, APP, CHRM1, EGFR, HCAR2, HSP90AB1, PTGS2, SMAD3, SRC | 2.22502 |
[BP] GO:0032102 | negative regulation of response to external stimulus | ADORA1, ALOX12, CYP19A1, PPARA, PPARG, SMAD3, TEK | 2.22481 |
[BP] GO:0032103 | positive regulation of response to external stimulus | EGFR, FABP4, KDR, MET, PRKCA, PTGS2, SMAD3 | 2.22481 |
[BP] GO:2000573 | positive regulation of DNA biosynthetic process | AURKB, HSP90AA1, HSP90AB1, SRC | 2.22481 |
[BP] GO:0065007 | biological regulation | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.21701 |
[BP] GO:0022600 | None | CHRM1, CHRM3, CHRM5, SLC5A1 | 2.20045 |
[BP] GO:0002009 | morphogenesis of an epithelium | CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 2.1998 |
[BP] GO:0097746 | None | ADORA1, CHRM1, CHRM3, EGFR, PTGS2 | 2.1862 |
[BP] GO:0035296 | None | ADORA1, CHRM1, CHRM3, EGFR, PTGS2 | 2.1862 |
[BP] GO:1903522 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, EGFR, PTGS2 | 2.17711 |
[BP] GO:0043065 | positive regulation of apoptotic process | CYP1B1, HCAR2, MMP9, PIK3CB, PPARG, PTGS2, SMAD3, SRC, TRPV1, XDH | 2.16296 |
[BP] GO:0006706 | steroid catabolic process | CYP19A1, CYP1A2, CYP3A4 | 2.1576 |
[BP] GO:1903393 | None | KDR, SMAD3, TEK | 2.1576 |
[BP] GO:0045785 | positive regulation of cell adhesion | ALOX12, ALOX15, KDR, PIK3CA, PRKCA, SMAD3, SRC, TEK | 2.14706 |
[BP] GO:0051090 | regulation of DNA binding transcription factor activity | ADORA3, APP, CYP1B1, ESR1, ESR2, HSPA1A, PIM1, PPARG | 2.14662 |
[BP] GO:0046541 | None | CHRM1, CHRM3 | 2.14662 |
[BP] GO:0032800 | receptor biosynthetic process | ACHE, PPARG | 2.14662 |
[BP] GO:0051122 | hepoxilin biosynthetic process | ALOX12, ALOX15 | 2.14662 |
[BP] GO:0051121 | hepoxilin metabolic process | ALOX12, ALOX15 | 2.14662 |
[BP] GO:0010891 | None | PPARA, PPARG | 2.14662 |
[BP] GO:0043068 | positive regulation of programmed cell death | CYP1B1, HCAR2, MMP9, PIK3CB, PPARG, PTGS2, SMAD3, SRC, TRPV1, XDH | 2.14128 |
[BP] GO:0010638 | positive regulation of organelle organization | ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 2.13073 |
[BP] GO:0006352 | DNA-templated transcription, initiation | ESR1, ESR2, NR3C1, PPARA, PPARG, RORC | 2.11993 |
[BP] GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, SRC | 2.11571 |
[BP] GO:0046683 | response to organophosphorus | APP, PTGS2, TEK, TRPV1, TYR | 2.11571 |
[BP] GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, SRC | 2.11571 |
[BP] GO:0006811 | None | CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, FABP3, PPARA, PPARG, SLC5A1, SLC5A2, SLC5A4, TRPV1 | 2.11485 |
[BP] GO:0045765 | regulation of angiogenesis | ALOX12, CYP1B1, KDR, PPARG, PRKCA, PTGS2, TEK | 2.094 |
[BP] GO:1901653 | cellular response to peptide | AKR1B1, APP, IGF1R, INSR, PPARG, SRC | 2.094 |
[BP] GO:2000021 | regulation of ion homeostasis | ADORA1, CA2, CA7, KDR, SRC, TRPV1 | 2.094 |
[BP] GO:0051171 | regulation of nitrogen compound metabolic process | ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.094 |
[BP] GO:0050880 | None | ADORA1, CHRM1, CHRM3, EGFR, PTGS2 | 2.0918 |
[BP] GO:0002431 | Fc receptor mediated stimulatory signaling pathway | HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, SRC | 2.0918 |
[BP] GO:0046320 | None | FABP3, PPARA, PPARG | 2.09131 |
[BP] GO:0034219 | None | SLC5A1, SLC5A2, SLC5A4 | 2.09131 |
[BP] GO:0071634 | None | HSP90AB1, PTGS2, SMAD3 | 2.09131 |
[BP] GO:0008209 | androgen metabolic process | CYP19A1, CYP3A4, ESR1 | 2.09131 |
[BP] GO:0052548 | None | APP, CSNK2A1, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH | 2.08811 |
[BP] GO:0001936 | None | KDR, PPARG, PRKCA, TEK, XDH | 2.08332 |
[BP] GO:0035150 | None | ADORA1, CHRM1, CHRM3, EGFR, PTGS2 | 2.08332 |
[BP] GO:0050878 | regulation of body fluid levels | ADORA1, AKR1B1, ALOX12, CHRM1, CHRM3, MET, PRKCA, XDH | 2.08332 |
[BP] GO:0050776 | regulation of immune response | ALOX15, DUSP3, ESR1, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PIK3CA, PIK3CB, PPARG, PTPN1, SMAD3, SRC | 2.07676 |
[BP] GO:0050804 | modulation of chemical synaptic transmission | ACHE, ADORA1, APP, CA2, CA7, EGFR, PTGS2 | 2.07259 |
[BP] GO:0099177 | regulation of trans-synaptic signaling | ACHE, ADORA1, APP, CA2, CA7, EGFR, PTGS2 | 2.07259 |
[BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 2.07259 |
[BP] GO:0038094 | Fc-gamma receptor signaling pathway | HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, SRC | 2.07259 |
[BP] GO:1904951 | positive regulation of establishment of protein localization | ACHE, APP, CHRM1, EGFR, HCAR2, HSP90AB1, PTGS2, SMAD3, SRC | 2.05747 |
[BP] GO:0043627 | response to estrogen | CA2, ESR1, PPARG, TEK | 2.05711 |
[BP] GO:0031099 | regeneration | AXL, CSNK2A1, EGFR, FLT3, PPARG | 2.04771 |
[BP] GO:0071383 | None | EGFR, FLT3, NR3C1, SRC | 2.0375 |
[BP] GO:0032872 | regulation of stress-activated MAPK cascade | APP, DUSP3, EGFR, IGF1R, PTPN1, XDH | 2.0375 |
[BP] GO:0070302 | regulation of stress-activated protein kinase signaling cascade | APP, DUSP3, EGFR, IGF1R, PTPN1, XDH | 2.02747 |
[BP] GO:0009968 | negative regulation of signal transduction | DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PPARG, PTGS2, PTPN1, SMAD3, SRC, XDH | 2.02531 |
[BP] GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | FLT3, SRC, TEK | 2.02087 |
[BP] GO:0042743 | hydrogen peroxide metabolic process | CYP1A1, CYP1A2, EGFR | 2.02087 |
[BP] GO:0098771 | inorganic ion homeostasis | APP, CA12, CA2, CA7, EGFR, ESR1, GPR35, PIK3CB, SMAD3, TRPV1 | 2.02087 |
[BP] GO:0051336 | regulation of hydrolase activity | APP, CSNK2A1, EGFR, ESR1, HSP90AB1, HSPA1A, MMP9, NUAK1, PPARG, PTGS2, PTPN1, SMAD3, SRC, XDH | 2.02087 |
[BP] GO:0033029 | regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.02087 |
[BP] GO:0010887 | None | PPARA, PPARG | 2.02087 |
[BP] GO:0010871 | None | PPARA, PPARG | 2.02087 |
[BP] GO:1990535 | None | APP, INSR | 2.02087 |
[BP] GO:0002933 | lipid hydroxylation | CYP1A1, CYP3A4 | 2.02087 |
[BP] GO:0016098 | monoterpenoid metabolic process | CYP1A2, CYP3A4 | 2.02087 |
[BP] GO:0032868 | None | FABP3, INSR, PPARA, PPARG, SRC | 2.01942 |
[BP] GO:0048545 | response to steroid hormone | CA2, EGFR, FLT3, NR3C1, PTGS2, SRC | 2.00876 |
[BP] GO:0010557 | positive regulation of macromolecule biosynthetic process | APP, AURKB, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, RORC, SMAD3, SRC | 2.00217 |
[CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, ESR1, FLT3, GPR35, HCAR2, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PTPN1, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TRPV1 | 4.72915 |
[CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TRPV1, TYR | 4.72915 |
[CC] GO:0044459 | plasma membrane part | ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DUSP3, EGFR, FLT3, GPR35, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PTGS2, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TRPV1 | 4.6646 |
[CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TRPV1, TYR | 4.55916 |
[CC] GO:0098590 | plasma membrane region | ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, HSP90AA1, HSP90AB1, INSR, MET, PTGS2, SRC, TEK, TRPV1 | 4.51873 |
[CC] GO:0016323 | basolateral plasma membrane | ADORA1, CA2, CA4, CA9, CHRM3, EGFR, HSP90AB1, TEK | 4.05836 |
[CC] GO:0031226 | intrinsic component of plasma membrane | ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, TEK, TRPV1 | 4.02696 |
[CC] GO:0005887 | integral component of plasma membrane | ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC5A1, SLC5A2, SLC5A4, TEK, TRPV1 | 3.7359 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TRPV1, TYR, XDH | 3.14225 |
[CC] GO:0031253 | None | ADORA1, CA4, CA9, HSP90AA1, HSP90AB1, INSR, SRC, TRPV1 | 2.66365 |
[CC] GO:0044463 | None | ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, HSP90AA1, HSP90AB1, INSR, PTGS1, SRC, TRPV1 | 2.43944 |
[CC] GO:0120038 | None | ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, HSP90AA1, HSP90AB1, INSR, PTGS1, SRC, TRPV1 | 2.43944 |
[CC] GO:0045202 | None | ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR | 2.38032 |
[CC] GO:1904813 | None | ALOX5, HSP90AA1, HSP90AB1, HSPA1A, MMP9 | 2.1862 |
[CC] GO:0044432 | endoplasmic reticulum part | APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 | 2.14662 |
[CC] GO:0045121 | membrane raft | APP, EGFR, INSR, KDR, PTGS2, SRC, TEK | 2.12241 |
[CC] GO:0098857 | membrane microdomain | APP, EGFR, INSR, KDR, PTGS2, SRC, TEK | 2.11053 |
[CC] GO:0044464 | cell part | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC5A1, SLC5A2, SLC5A4, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 2.05711 |
[CC] GO:0097443 | sorting endosome | KDR, PTPN1 | 2.02087 |
[CC] GO:0048471 | perinuclear region of cytoplasm | ACHE, AKR1B1, APP, CA4, EGFR, HSPA1A, PPARG, PRKCA, SRC, TYR | 2.00876 |
[MF] GO:0046914 | transition metal ion binding | ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, TYR, XDH | 16.5455 |
[MF] GO:0043167 | ion binding | ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR, XDH | 11.4268 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SRC, TEK, TYR, XDH | 11.4268 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, SRC, TEK, TRPV1 | 11.0549 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 9.73621 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 9.2026 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 | 8.21896 |
[MF] GO:0005506 | iron ion binding | ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH | 7.64815 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC | 7.3177 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 7.19255 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC | 7.06484 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, NR3C1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3 | 6.89548 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 | 6.88017 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, TYR | 6.66813 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 6.50115 |
[MF] GO:0016907 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.42883 |
[MF] GO:0043169 | cation binding | ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TRPV1, TYR, XDH | 6.34359 |
[MF] GO:0042562 | hormone binding | ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NQO2, NR3C1 | 6.32501 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, RORC, TEK, TRPV1 | 6.24644 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.23046 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK | 6.14717 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR | 6.01388 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, SRC, TEK | 5.92862 |
[MF] GO:0030235 | nitric-oxide synthase regulator activity | EGFR, ESR1, HSP90AA1, HSP90AB1 | 5.76669 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK | 5.69652 |
[MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 5.42864 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, RORC, TEK, TRPV1 | 5.41877 |
[MF] GO:0046872 | metal ion binding | ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TRPV1, TYR, XDH | 5.39763 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 | 5.37029 |
[MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, RORC, SMAD3, TEK, TRPV1 | 5.34116 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK | 5.22072 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, RORC, TEK, TRPV1 | 5.21625 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH | 5.0695 |
[MF] GO:0043560 | insulin receptor substrate binding | IGF1R, INSR, PIK3CA, PIK3CB | 4.94902 |
[MF] GO:0003707 | steroid hormone receptor activity | ESR1, ESR2, NR3C1, PPARA, PPARG, RORC | 4.75414 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 | 4.53782 |
[MF] GO:0036094 | small molecule binding | ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, SRC, TEK, TRPV1, XDH | 4.36531 |
[MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK | 4.3238 |
[MF] GO:0015464 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.09617 |
[MF] GO:0005524 | ATP binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TRPV1 | 4.00591 |
[MF] GO:0043168 | anion binding | ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, SRC, TEK, TRPV1, XDH | 3.99426 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH | 3.90709 |
[MF] GO:0005496 | steroid binding | CYP3A4, ESR1, ESR2, HSD17B1, NR3C1, RORC | 3.9023 |
[MF] GO:0005412 | None | SLC5A1, SLC5A2, SLC5A4 | 3.9023 |
[MF] GO:0032559 | adenyl ribonucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TRPV1 | 3.88102 |
[MF] GO:0030554 | adenyl nucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TRPV1 | 3.8391 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC | 3.83487 |
[MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | ESR1, ESR2, PPARA, PPARG, RORC | 3.83402 |
[MF] GO:0004879 | nuclear receptor activity | ESR1, ESR2, PPARA, PPARG, RORC | 3.83402 |
[MF] GO:0099600 | transmembrane receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK, TRPV1 | 3.81143 |
[MF] GO:0004888 | transmembrane signaling receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK, TRPV1 | 3.81143 |
[MF] GO:0019899 | enzyme binding | APP, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, HSPA1A, MET, NR3C1, PPARA, PPARG, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK | 3.66136 |
[MF] GO:0008289 | lipid binding | ALOX15, AXL, CYP3A4, ESR1, ESR2, FABP3, FABP4, HSD17B1, NR3C1, PPARA, PPARG, RORC, TRPV1 | 3.64063 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, EGFR, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC | 3.6121 |
[MF] GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | ALOX12, ALOX15, ALOX5, PTGS2 | 3.54095 |
[MF] GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | ALOX12, ALOX15, ALOX5, PTGS2 | 3.4796 |
[MF] GO:0031072 | heat shock protein binding | ADORA1, CSNK2A1, HSP90AB1, HSPA1A, KDR, NR3C1 | 3.47611 |
[MF] GO:0042802 | identical protein binding | ACHE, APP, CSNK2A1, EGFR, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NQO2, PPARG, PTGS2, SMAD3, TRPV1, TYR, XDH | 3.45903 |
[MF] GO:0000166 | nucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TRPV1, XDH | 3.42942 |
[MF] GO:1901265 | nucleoside phosphate binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TRPV1, XDH | 3.42762 |
[MF] GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | CYP1A2, CYP3A4, XDH | 3.37888 |
[MF] GO:0004716 | signal transducer, downstream of receptor, with protein tyrosine kinase activity | EGFR, INSR, KDR | 3.37888 |
[MF] GO:0004629 | None | ADORA1, CHRM1, CHRM3, CHRM5 | 3.31989 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 | 3.20337 |
[MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 3.17113 |
[MF] GO:0099528 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 2.9717 |
[MF] GO:0004666 | prostaglandin-endoperoxide synthase activity | PTGS1, PTGS2 | 2.9717 |
[MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.9717 |
[MF] GO:0047977 | hepoxilin-epoxide hydrolase activity | ALOX12, ALOX15 | 2.9717 |
[MF] GO:0008389 | None | CYP2A13, CYP2A6 | 2.9717 |
[MF] GO:0035639 | purine ribonucleoside triphosphate binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TRPV1 | 2.88522 |
[MF] GO:0097367 | carbohydrate derivative binding | ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TRPV1 | 2.79169 |
[MF] GO:0035258 | None | ESR1, FLT3, PPARG, SMAD3, SRC | 2.7745 |
[MF] GO:0032555 | purine ribonucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TRPV1 | 2.75908 |
[MF] GO:0051213 | dioxygenase activity | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 2.73225 |
[MF] GO:0017076 | purine nucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TRPV1 | 2.72487 |
[MF] GO:0032553 | ribonucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TRPV1 | 2.71605 |
[MF] GO:1901363 | heterocyclic compound binding | ADORA1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, ESR2, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.69349 |
[MF] GO:0097159 | organic cyclic compound binding | ADORA1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, ESR2, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH | 2.64438 |
[MF] GO:0050473 | arachidonate 15-lipoxygenase activity | ALOX15, PTGS2 | 2.56919 |
[MF] GO:0070576 | vitamin D 24-hydroxylase activity | CYP1A1, CYP3A4 | 2.56919 |
[MF] GO:0004052 | arachidonate 12-lipoxygenase activity | ALOX12, ALOX15 | 2.56919 |
[MF] GO:0051120 | hepoxilin A3 synthase activity | ALOX12, ALOX15 | 2.56919 |
[MF] GO:0019902 | phosphatase binding | EGFR, MET, PPARA, PPARG, PTPN1, SMAD3 | 2.54938 |
[MF] GO:0019900 | None | AURKB, CDC25B, DUSP3, EGFR, ESR1, HSP90AA1, HSP90AB1, NR3C1, PTPN1, SMAD3, SRC | 2.48927 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, CYP19A1, CYP1A2, NQO2, XDH | 2.41672 |
[MF] GO:0005355 | None | SLC5A1, SLC5A2, SLC5A4 | 2.38982 |
[MF] GO:0008227 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 2.38498 |
[MF] GO:0015149 | None | SLC5A1, SLC5A2, SLC5A4 | 2.34092 |
[MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.32714 |
[MF] GO:0034875 | caffeine oxidase activity | CYP1A2, CYP3A4 | 2.32714 |
[MF] GO:0051425 | None | APP, INSR | 2.32714 |
[MF] GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | CYP1A2, CYP3A4 | 2.32714 |
[MF] GO:0019901 | None | CDC25B, DUSP3, EGFR, ESR1, HSP90AA1, HSP90AB1, NR3C1, PTPN1, SMAD3, SRC | 2.31769 |
[MF] GO:0015145 | None | SLC5A1, SLC5A2, SLC5A4 | 2.24474 |
[MF] GO:0140096 | catalytic activity, acting on a protein | AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PTPN1, SRC, TEK | 2.18779 |
[MF] GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | EGFR, MET, PIK3CA, PIK3CB | 2.18031 |
[MF] GO:0101020 | estrogen 16-alpha-hydroxylase activity | CYP1A1, CYP3A4 | 2.14662 |
[MF] GO:0030284 | estrogen receptor activity | ESR1, ESR2 | 2.14662 |
[MF] GO:0043559 | insulin binding | IGF1R, INSR | 2.14662 |
[MF] GO:0052813 | phosphatidylinositol bisphosphate kinase activity | EGFR, MET, PIK3CA, PIK3CB | 2.12332 |
[MF] GO:0005504 | None | FABP3, FABP4, PPARG | 2.12332 |
[MF] GO:0004435 | None | CHRM1, CHRM3, CHRM5 | 2.12332 |
[MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD17B1, HSD17B2 | 2.12332 |
[MF] GO:0019838 | growth factor binding | EGFR, IGF1R, INSR, KDR, TEK | 2.11571 |
[MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD17B1, HSD17B2 | 2.05711 |
[MF] GO:0043548 | phosphatidylinositol 3-kinase binding | AXL, IGF1R, INSR | 2.05711 |
[MF] GO:0035004 | phosphatidylinositol 3-kinase activity | EGFR, MET, PIK3CA, PIK3CB | 2.0375 |
[MF] GO:0050543 | None | FABP3, PPARG | 2.02087 |
[MF] GO:0004064 | arylesterase activity | CA1, CA2 | 2.02087 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Estrogen signaling pathway_Homo sapiens_hsa04915 | HSP90AA1, HSP90AB1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A | 10.8435 |
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R | 10.8435 |
Pathways in cancer_Homo sapiens_hsa05200 | HSP90AA1, SMAD3, HSP90AB1, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, PIK3CA, PPARG, MET | 9.0399 |
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA9, CA14 | 10.8435 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | PIK3CA, SRC, MMP2, KDR, PRKCA, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R | 8.1128 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CHRM2, HSP90AA1, HSP90AB1, CHRM1, INSR, PRKCA, PIK3CB, EGFR, IGF1R, PIK3CA, KDR, TEK, MET | 8.0181 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 | 9.0399 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 | 8.8108 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 8.1128 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 8.1128 |
Cholinergic synapse_Homo sapiens_hsa04725 | CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, PRKCA, PIK3CB | 6.8551 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | PIK3CA, SRC, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R | 6.9359 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 | 7.5342 |
Metabolic pathways_Homo sapiens_hsa01100 | CBR1, ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH | 5.8019 |
VEGF signaling pathway_Homo sapiens_hsa04370 | PIK3CA, SRC, KDR, PRKCA, PIK3CB, PTGS2 | 5.828 |
Ras signaling pathway_Homo sapiens_hsa04014 | PIK3CA, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R | 5.6819 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | PIK3CA, INSR, PRKCA, TEK, PIK3CB, EGFR, IGF1R | 5.828 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 | 5.828 |
Serotonergic synapse_Homo sapiens_hsa04726 | APP, ALOX5, ALOX15, PRKCA, ALOX12, PTGS2, PTGS1 | 5.6525 |
Focal adhesion_Homo sapiens_hsa04510 | PIK3CA, SRC, KDR, PRKCA, PIK3CB, MET, EGFR, IGF1R | 5.0737 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | CHRM2, CHRM3, CHRM1, GPR35, ADORA3, CHRM5, ADORA1, TRPV1, NR3C1 | 5.0689 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB, EGFR | 4.9412 |
Prostate cancer_Homo sapiens_hsa05215 | HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, EGFR, IGF1R | 5.0689 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | PIK3CA, PIM1, CYP1B1, PRKCA, PTGS2, MMP9, MET, EGFR, CDC25B | 4.8897 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | PIK3CA, SRC, PRKCA, ALOX12, PIK3CB, TRPV1 | 4.8897 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIK3CA, MMP2, PIM1, PRKCA, PIK3CB | 4.8283 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, CDC25B, IGF1R | 4.8897 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9, EGFR | 5.3728 |
cAMP signaling pathway_Homo sapiens_hsa04024 | CHRM2, HCAR2, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA | 4.2616 |
Glioma_Homo sapiens_hsa05214 | PIK3CA, PRKCA, PIK3CB, EGFR, IGF1R | 4.5522 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A | 4.5714 |
Hepatitis B_Homo sapiens_hsa05161 | SMAD3, PIK3CA, SRC, PRKCA, PIK3CB, MMP9 | 4.0409 |
FoxO signaling pathway_Homo sapiens_hsa04068 | SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R | 4.2431 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | PIK3CA, FLT3, PIK3CB, MET, EGFR | 4.5006 |
Melanoma_Homo sapiens_hsa05218 | PIK3CA, PIK3CB, MET, EGFR, IGF1R | 4.4024 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | PIK3CA, SRC, PIK3CB, ESR1, ESR2 | 4.3851 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | PIK3CA, SRC, PRKCA, PIK3CB, PTGS2, EGFR | 3.8745 |
Endocytosis_Homo sapiens_hsa04144 | SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A | 3.616 |
ErbB signaling pathway_Homo sapiens_hsa04012 | PIK3CA, SRC, PRKCA, PIK3CB, EGFR | 4.0409 |
Calcium signaling pathway_Homo sapiens_hsa04020 | CHRM2, CHRM3, CHRM1, CHRM5, PRKCA, EGFR | 3.6047 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | PIK3CA, INSR, PPARG, PIK3CB, IGF1R | 3.8887 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARG, PPARA | 4.4508 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PIK3CA, INSR, PIK3CB, PPARA | 3.616 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | PIK3CA, SRC, PRKCA, PIK3CB, ESR1 | 3.4939 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | PIK3CA, MMP2, PRKCA, PIK3CB, MMP9 | 3.4939 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | PIK3CA, ADORA3, ADORA1, PRKCA, PIK3CB | 3.4681 |
AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, INSR, PPARG, PIK3CB, IGF1R | 3.4179 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | PIK3CA, INSR, PRKCA, PIK3CB, EGFR | 3.1464 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | PIK3CA, ADORA3, INSR, ADORA1, PIK3CB | 2.8655 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, PPARG, MMP9, MET, IGF1R | 2.7395 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2, PRKCA, EGFR | 2.901 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | PIK3CA, PRKCA, PIK3CB, EGFR | 3.616 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | PIK3CA, PRKCA, PIK3CB, EGFR | 2.7518 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.6047 |
TNF signaling pathway_Homo sapiens_hsa04668 | PIK3CA, PIK3CB, PTGS2, MMP9 | 2.6474 |
Platelet activation_Homo sapiens_hsa04611 | PIK3CA, SRC, PIK3CB, PTGS1 | 2.4999 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | PIK3CA, SRC, PIK3CB, MET | 3.1464 |
Pancreatic cancer_Homo sapiens_hsa05212 | SMAD3, PIK3CA, PIK3CB, EGFR | 3.407 |
Toxoplasmosis_Homo sapiens_hsa05145 | PIK3CA, ALOX5, PIK3CB, HSPA1A | 2.5471 |
Hepatitis C_Homo sapiens_hsa05160 | PIK3CA, PIK3CB, PPARA, EGFR | 2.3747 |
Measles_Homo sapiens_hsa05162 | CSNK2A1, PIK3CA, PIK3CB, HSPA1A | 2.3514 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1, CYP3A4 | 3.4179 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, PIK3CA, INSR, PIK3CB | 2.3228 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | SMAD3, PIK3CA, PIK3CB, IGF1R | 2.3009 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PIK3CA, INSR, PIK3CB, PPARA | 2.2323 |
MAPK signaling pathway_Homo sapiens_hsa04010 | DUSP3, PRKCA, EGFR, CDC25B, HSPA1A | 2.2066 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, INSR, PRKCA, PIK3CB | 4.171 |
Influenza A_Homo sapiens_hsa05164 | PIK3CA, PRKCA, PIK3CB, HSPA1A | 2.0401 |
Huntington's disease_Homo sapiens_hsa05016 | PPARG | 0.2784 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.2884 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.2983 |
Tuberculosis_Homo sapiens_hsa05152 | SRC | 0.2974 |
Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3099 |
Hippo signaling pathway_Homo sapiens_hsa04390 | SMAD3 | 0.3367 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, PIK3CA, PIK3CB, HSPA1A | 1.8652 |
Spliceosome_Homo sapiens_hsa03040 | HSPA1A | 0.3773 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.39 |
Dopaminergic synapse_Homo sapiens_hsa04728 | PRKCA | 0.3873 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.398 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET, EGFR | 1.4996 |
Vascular smooth muscle contraction_Homo sapiens_hsa04270 | PRKCA | 0.4038 |
Glutamatergic synapse_Homo sapiens_hsa04724 | PRKCA | 0.4187 |
Wnt signaling pathway_Homo sapiens_hsa04310 | SMAD3, CSNK2A1, PRKCA | 1.5354 |
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PIK3CA, PRKCA, PIK3CB | 1.5849 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.4585 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC, PRKCA | 1.5555 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, PRKCA, PIK3CB | 1.4966 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | HSP90AA1, HSP90AB1, HSPA1A | 1.3717 |
Osteoclast differentiation_Homo sapiens_hsa04380 | PIK3CA, PPARG, PIK3CB | 1.6064 |
Viral carcinogenesis_Homo sapiens_hsa05203 | PIK3CA, SRC, PIK3CB | 1.1802 |
HTLV-I infection_Homo sapiens_hsa05166 | SMAD3, PIK3CA, PIK3CB | 0.9772 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIK3CA, PIM1, PIK3CB | 1.439 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.4777 |
Circadian entrainment_Homo sapiens_hsa04713 | PRKCA | 0.4777 |
Apoptosis_Homo sapiens_hsa04210 | PIK3CA, PIK3CB | 0.8804 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | PIK3CA, SRC, PIK3CB | 1.2719 |
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PIK3CA, PRKCA, PIK3CB | 1.9743 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.4972 |
Taste transduction_Homo sapiens_hsa04742 | CHRM3 | 0.5129 |
TGF-beta signaling pathway_Homo sapiens_hsa04350 | SMAD3 | 0.5113 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | SMAD3, PIK3CA, PIK3CB | 1.8687 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.4958 |
Cell cycle_Homo sapiens_hsa04110 | SMAD3, CDC25B | 0.9562 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | PIK3CA, PIK3CB | 0.9772 |
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PIK3CA, PRKCA, PIK3CB | 1.9259 |
Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PRKCA, PIK3CB | 1.9108 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.5129 |
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | PRKCA | 0.5163 |
Pancreatic secretion_Homo sapiens_hsa04972 | CHRM3, CA2, PRKCA | 1.9458 |
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PIK3CA, PRKCA, PIK3CB | 2.2948 |
mTOR signaling pathway_Homo sapiens_hsa04150 | PIK3CA, PRKCA, PIK3CB | 2.4033 |
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | PIK3CA, PIK3CB | 1.0636 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | SMAD3, PIK3CA, PIK3CB | 2.229 |
Small cell lung cancer_Homo sapiens_hsa05222 | PIK3CA, PIK3CB, PTGS2 | 2.0542 |
Melanogenesis_Homo sapiens_hsa04916 | PRKCA, TYR | 1.0976 |
Gap junction_Homo sapiens_hsa04540 | SRC, PRKCA, EGFR | 2.0363 |
T cell receptor signaling pathway_Homo sapiens_hsa04660 | PIK3CA, PIK3CB | 1.0746 |
Leishmaniasis_Homo sapiens_hsa05140 | PTGS2 | 0.5522 |
Renal cell carcinoma_Homo sapiens_hsa05211 | PIK3CA, PIK3CB, MET | 2.3146 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | PRKCA, PTGS2 | 1.0935 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5621 |
Gastric acid secretion_Homo sapiens_hsa04971 | CHRM3, CA2, PRKCA | 2.2175 |
Thyroid hormone synthesis_Homo sapiens_hsa04918 | PRKCA | 0.5597 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1, PRKCA | 1.1631 |
Colorectal cancer_Homo sapiens_hsa05210 | SMAD3, PIK3CA, PIK3CB | 2.3747 |
Long-term potentiation_Homo sapiens_hsa04720 | PRKCA | 0.5786 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1, TEK | 1.1681 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, PTGS2 | 1.1499 |
Salivary secretion_Homo sapiens_hsa04970 | CHRM3, PRKCA | 1.1731 |
Amphetamine addiction_Homo sapiens_hsa05031 | PRKCA | 0.5758 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC, PRKCA | 1.1782 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET, EGFR | 2.2948 |
Insulin secretion_Homo sapiens_hsa04911 | CHRM3, PRKCA | 1.1977 |
Bile secretion_Homo sapiens_hsa04976 | CA2, SLC5A1, CYP3A4 | 2.2524 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.5844 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.5814 |
Antigen processing and presentation_Homo sapiens_hsa04612 | HSP90AA1, HSP90AB1, HSPA1A | 2.1791 |
Endometrial cancer_Homo sapiens_hsa05213 | PIK3CA, PIK3CB, EGFR | 2.5643 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, CYP1A2, CYP3A4 | 2.2823 |
B cell receptor signaling pathway_Homo sapiens_hsa04662 | PIK3CA, PIK3CB | 1.3103 |
Legionellosis_Homo sapiens_hsa05134 | HSPA1A | 0.64 |
Inositol phosphate metabolism_Homo sapiens_hsa00562 | PIK3CA, PIK3CB | 1.3285 |
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | PRKCA | 0.64 |
Vibrio cholerae infection_Homo sapiens_hsa05110 | PRKCA | 0.6633 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | PIK3CA, INSR, PIK3CB | 2.6527 |
Mineral absorption_Homo sapiens_hsa04978 | SLC5A1 | 0.6633 |
Malaria_Homo sapiens_hsa05144 | MET | 0.6728 |
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | PIK3CA, SLC5A1, PIK3CB | 2.7212 |
Long-term depression_Homo sapiens_hsa04730 | PRKCA, IGF1R | 1.4483 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | SMAD3, RORC | 1.3916 |
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | HSP90AA1, HSP90AB1 | 1.4817 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.4578 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, CYP3A4, XDH | 2.7001 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 2.8508 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | PRKCA, ESR1 | 1.6103 |
Prion diseases_Homo sapiens_hsa05020 | HSPA1A | 0.8047 |
African trypanosomiasis_Homo sapiens_hsa05143 | PRKCA | 0.8047 |
Thyroid cancer_Homo sapiens_hsa05216 | PPARG | 0.8652 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.8444 |
Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.8047 |
Dorso-ventral axis formation_Homo sapiens_hsa04320 | EGFR | 0.8881 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | ALOX15, CYP1A2, CYP3A4 | 3.2311 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.8969 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.9504 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.8545 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.8881 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.9108 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.8286 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.1534 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 5.3549 |