TCM Prescription: Kun Bao Pills



Prescription Description
Prescription IDTCMF4652
Pinyin NameKun Bao Wan
Chinese Name坤宝丸
English NameKun Bao Pills
Function Description月经失调, 绝经前后诸症
IndicationsMenopausal disorder, Irregular menstruation
Disease ICD-11 Category SB95 [Menopausal disorder (TM1), 绝经前后诸症 (TM1) ];
GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH611 Rubus idaeus 覆盆子 TCMH611 ITSAE336-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH746 Carapax et plastrum testudinis 龟甲 TCMH746
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH1542 Radix adenophorae 南沙参 TCMH1542
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
TCMH2610 Concha margaritifera usta;Margarita 珍珠母 TCMH2610
TCMH1933 Herba dendrobii 石斛 TCMH1933
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH1797 Morus alba 桑叶 TCMH1797 ITSAL1073-14
TCMH110 Cynanchum atratum 白薇 TCMH110
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT118 MGAM Maltase-glucoamylase Hydrolase O43451
TCMT124 FUCA1 Alpha-L-fucosidase I Hydrolase P04066
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT237 SLC5A1 Sodium/glucose cotransporter 1 Transporter P13866
TCMT238 SLC5A2 Sodium/glucose cotransporter 2 Transporter P31639
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT347 MAN1B1 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Hydrolase Q9UKM7
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT847 SLC5A4 Low affinity sodium-glucose cotransporter Transporter Q9NY91
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, FABP3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSPA1A, PDE5A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 12.5625
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC5A2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 12.1642
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MGAM, MMP1, MMP2, NQO2, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 11.0803
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GAA, GBA, GPR35, HCAR2, HIF1A, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOB, MCL1, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.9383
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.9383
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.9259
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUCA1, FUT7, GBA, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.8802
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.4248
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.60763
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MCL1, MMP2, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 9.35187
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, GAA, HSD11B1, HSD17B1, HSD17B2, MAOB, NQO2, PHF8, PTGS1, PTGS2, TYR, XDH 9.19194
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, GBA, HSD17B2, IGF1R, INSR, MAOB, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR 8.78085
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MCL1, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TYR 8.52337
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, HIF1A, KDR, MAOB, MMP9, PTGS2, SRC, TERT 8.52337
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, FUT7, GAA, GBA, GLO1, HIF1A, HSD11B1, HSD17B2, INSR, KDR, MAOB, MCL1, MET, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR 8.52337
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.52337
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FLT3, HIF1A, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 8.39536
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GBA, GLO1, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.38149
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.38149
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FABP3, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOB, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 8.27715
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 8.17558
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GBA, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.98526
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.98526
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.95228
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.88022
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.83631
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOB, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 7.80486
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC5A2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.68315
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC, TERT 7.47015
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.34168
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.34168
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.3001
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUCA1, FUT7, GBA, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.21124
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC5A2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.12174
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.12174
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.09835
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ESR1, FABP3, FLT3, GBA, IGF1R, INSR, MAOB, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 7.07764
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 6.71472
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC 6.69128
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, GAA, GBA, HIF1A, HSD17B2, IGF1R, INSR, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC5A1, SMAD3, SRC, TEK, TNKS2, TYR 6.66472
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 6.66472
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GAA, HIF1A, HSD11B1, HSD17B2, INSR, KDR, MAOB, MCL1, MMP9, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TYR 6.55445
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GBA, HSD17B2, MAOB, PTGS2, RORC, SRC, TYR 6.49005
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, GBA, MAOB, PTGS2, RORC, SRC, TEK, TYR 6.45221
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.45221
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CDK6, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 6.42201
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GBA, INSR, MAOB, PPARA, PTGS2, SRC, TEK 6.35312
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.33005
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.1862
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MAOB, MGAM, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CB, SRC, XDH 6.17446
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 6.10344
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.09063
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.07902
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.0787
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 5.99223
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DAO, GBA, HIF1A, MAOB, TYR 5.94207
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, HIF1A, INSR, MCL1, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 5.85185
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 5.82805
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 5.82445
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.79701
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.77237
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CDK6, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 5.73689
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DAO, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUCA1, FUT7, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 5.72085
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HIF1A, HSD11B1, HSD17B2, INSR, KDR, PHF8, PIK3CA, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 5.71066
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 5.71066
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.69656
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.68206
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.63357
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FABP4, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.60578
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.60559
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, HIF1A, MAOB, MMP9, PTGS2, TERT 5.55822
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.4466
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, GBA, GLO1, GPR35, HIF1A, HSPA1A, IGF1R, KDR, MAOB, MCL1, MET, MMP12, MMP9, PDE5A, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.30865
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.29456
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FABP3, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.27846
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, EGFR, HCAR2, HIF1A, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 5.25497
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, EGFR, ESR1, FLT3, HIF1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 5.21647
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, GPR35, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 5.12639
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SRC 5.12357
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.12204
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, GPR35, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 5.11783
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.03648
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, GBA, HIF1A, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.03648
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, GBA, HIF1A, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.03648
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 5.03648
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 5.03081
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 5.03081
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.02614
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.98441
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.96821
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GBA, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MCL1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR 4.90159
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.89934
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FABP3, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.89934
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS 4.88632
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, GBA, GLO1, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MAOB, MCL1, MET, MMP12, MMP9, PDE5A, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.88545
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, ESR1, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.86048
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 4.76014
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 4.73624
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.70394
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PDE5A, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.68813
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, GBA, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.67566
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, NQO2, PTGS1, RORC 4.59828
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.58802
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 4.57365
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, GBA, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.51735
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, HIF1A, PPARA, PTGS1, PTGS2 4.48551
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.4153
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, DYRK1A, EGFR, HIF1A, HSPA1A, IGF1R, MCL1, MET, NUAK1, PTGS2, PTPN1, PTPRS, TERT, XDH 4.38714
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.35548
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, HIF1A, PIK3CB, PTGS2, TNKS, TNKS2 4.32322
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS, TOP2A 4.31413
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.29938
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DNMT1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 4.25915
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.25915
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HIF1A, HSD11B1, HSD17B1, HSD17B2 4.20794
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS 4.17218
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.08668
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DNMT1, ESR1, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.06236
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, EGFR, HSPA1A, MAOB 4.03526
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, ESR1, GAA, GBA, GPR35, HCAR2, HIF1A, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PDE5A, PIK3CA, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS2, XDH 4.03442
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 4.03442
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, HSPA1A, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.03442
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, EGFR, GPR35, HCAR2, HIF1A, HSPA1A, INSR, MAOB, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT 4.02658
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 4.01023
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.97197
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, HIF1A, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.96266
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, HSPA1A, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.9201
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GBA, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.89287
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DUSP3, EGFR, FLT3, GBA, IGF1R, INSR, KDR, PDE5A, PIK3CB, PTPN1, SRC, TEK, XDH 3.89051
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, GBA, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.88854
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, GBA, HIF1A, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TYR 3.88756
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 3.82668
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, GBA, HCAR2, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 3.82668
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, ALDH2, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MAOB, MGAM, PDE5A, XDH 3.82332
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, PIK3CA, SRC 3.80574
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 3.80574
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.7777
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, GBA, KDR, MAOB, PTGS2, SRC 3.77345
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUCA1, GBA 3.71974
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, GBA, MAOB, PTGS2, SRC 3.71457
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.71223
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SRC, TERT 3.69631
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GBA, IGF1R, INSR, PDE5A, PIK3CB, PTPN1, SRC 3.69327
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SRC 3.66431
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GBA, GPR35, HIF1A, INSR, MET, PIK3CA, PIK3CB, SMAD3 3.6602
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.64963
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HCAR2, HIF1A, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 3.64278
[BP] GO:0016137 None AKR1B1, AKR1B10, FUCA1, GBA 3.62265
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.61007
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 3.59927
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 3.59662
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, GBA, MAOB, PTGS2, SRC 3.59662
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 3.59662
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2A6, CYP3A4, DAO, MAOB 3.59662
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.59662
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, PPARA, RORC, SRC, TOP2A 3.57532
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, HCAR2, HIF1A, INSR, MMP12, PTGS2, SMAD3, SRC, TERT 3.57532
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, FLT3, HIF1A, HSPA1A, INSR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.55099
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, FLT3, INSR, KDR, PDE5A, PIK3CB, PTPN1, SRC, TEK, XDH 3.54255
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.50659
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, HIF1A, INSR, PTGS2, SMAD3, XDH 3.49611
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, EGFR, GAA, GBA, GPR35, HCAR2, PDE5A, PTGS2, SMAD3 3.47955
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 3.47821
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK 3.46723
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, ALDH2, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, FABP3, FABP4, FUCA1, GAA, GBA, HSPA1A, MAOB, MGAM, PDE5A, PIK3CB, SRC, XDH 3.4406
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.41685
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, GBA, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.38682
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.38682
[BP] GO:0010634 positive regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 3.36814
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.33603
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.33366
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.31878
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.31878
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 3.30352
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.28182
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, PIK3CA, SRC 3.2487
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.2487
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.2487
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.22499
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 3.20279
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.17898
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.17898
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, ESR1, ESR2, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PHF8, PIK3CB, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.1469
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.14159
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.11542
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 3.11542
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.10886
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, GBA, MAOB, PTGS2 3.10841
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TERT, TNKS, TOP2A 3.08785
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GBA, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.08785
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUCA1, FUT7, GAA, HSPA1A, MGAM, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC 3.05932
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 3.05752
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MCL1, MET, PIK3CA, PPARA, SMAD3 3.04952
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 3.04089
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 3.03134
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 3.02241
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DUSP3, ESR1, HCAR2, HIF1A, HSPA1A, MMP12, MMP2, PDE5A, PIK3CA, PIK3CB, PTPN1, PTPRS, SMAD3, SRC 3.00771
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 2.99995
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, GBA, HIF1A, HSPA1A, MCL1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A 2.99995
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CHRM3, CYP1B1, EGFR, GBA, HCAR2, HIF1A, HSPA1A, KDR, MET, MMP12, MMP9, PDE5A, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 2.98979
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.97388
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, FLT3, HIF1A, HSPA1A, INSR, PDE5A, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 2.97153
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 2.96449
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.96329
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP2A 2.96329
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 2.91932
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4, PHF8 2.91932
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 2.90962
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC 2.90272
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.90272
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.90272
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MAOB 2.88186
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.87548
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 2.87542
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.87542
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.86535
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, EGFR, PTGS2, SRC, TEK 2.85778
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.85778
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KDR, PTGS2, SRC 2.85778
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MAOB 2.85492
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.85085
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, EGFR, GAA, PDE5A, PTGS2 2.82942
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.81415
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.78581
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.76438
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.75957
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, CYP3A4, DAO, GBA, TYR 2.75311
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, CYP19A1, CYP1A2, MAOB, NQO2, XDH 2.75311
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, PTGS2 2.75311
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 2.73657
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC, TERT 2.72204
[BP] GO:2001251 None DNMT1, PHF8, SRC, TNKS, TNKS2, TOP2A 2.70944
[BP] GO:1902893 None HIF1A, PPARA, SMAD3, TERT 2.70944
[BP] GO:2001240 None BCL2, HSPA1A, MCL1, TERT 2.66733
[BP] GO:1901099 None BCL2, HSPA1A, MCL1, TERT 2.66733
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, ESR1, ESR2, FABP4, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.66206
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.66206
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT 2.64332
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, GBA, PPARA, SMAD3, TEK 2.64
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, GBA, MMP12, PPARA, SMAD3, TEK 2.62815
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.6134
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GBA, GLO1, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOB, MCL1, MET, MMP12, MMP9, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.60027
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, PPARA, PTGS2, SMAD3, TEK 2.58639
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, EGFR, ESR2, HIF1A, HSPA1A, INSR, PIK3CA, PIM1, PTPRS, SMAD3, TNKS2 2.58639
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC, TEK 2.57237
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.57237
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.56991
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.55029
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.5449
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.53828
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, GBA, MAOB, SRC 2.53828
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.53656
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 2.50249
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, GBA, MAOB 2.48641
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, FABP3, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, PHF8, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.48641
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.48641
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.48641
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, MAOB, SRC 2.48641
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 2.48641
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.48074
[BP] GO:0033043 regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, GBA, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, PHF8, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.46676
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 2.46401
[BP] GO:1901215 negative regulation of neuron death AXL, BCL2, GBA, HIF1A, PIK3CA, PPARA, TERT 2.44663
[BP] GO:0018958 None AKR1B1, BCL2, DAO, MAOB, TYR 2.44652
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 2.43568
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 2.43568
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, KDR, MET, MMP12, PPARA, PTGS2, PTPRS, SMAD3, TEK 2.43284
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 2.42534
[BP] GO:0001525 angiogenesis CYP1B1, HIF1A, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.42203
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.41816
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.41254
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.41254
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.40874
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GBA, GLO1, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.40842
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HIF1A, KDR, MCL1, MET, MMP2, MMP9, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A 2.40312
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HCAR2, HIF1A, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC5A1, SLC5A2, SLC5A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.4009
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GBA, IGF1R, INSR, PDE5A, PIK3CB, PTPN1, SRC 2.39879
[BP] GO:0032963 collagen metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.38924
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, EGFR, ESR1, ESR2, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP12, PHF8, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.37908
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HIF1A, HSD17B2, INSR, PTGS2, SRC 2.37342
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, HIF1A, PIK3CB 2.37103
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.37103
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, PDE5A, PIK3CB, PTPN1, SRC 2.35574
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.35574
[BP] GO:0070920 None EGFR, ESR1, TERT 2.35574
[BP] GO:0048546 None BCL2, EGFR, HIF1A 2.35574
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.35574
[BP] GO:0001961 None AXL, HIF1A, HSPA1A, MMP12 2.35574
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.35574
[BP] GO:0048731 system development ACHE, ADORA1, ALPL, CHRM1, CHRM2, CHRM3, DYRK1A, HIF1A, MMP9, PIK3CA, SMAD3, SRC, TEK 2.34575
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, FABP3, HSPA1A, PDE5A, PTGS2, SMAD3, TERT, XDH 2.34575
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.33408
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, CHRM1, EGFR, HCAR2, HIF1A, MMP12, PTGS2, SMAD3, SRC 2.33155
[BP] GO:0000023 None GAA, MGAM 2.32909
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.32909
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.32646
[BP] GO:0010595 positive regulation of endothelial cell migration HIF1A, KDR, MET, PTGS2, TEK 2.31998
[BP] GO:0044259 multicellular organismal macromolecule metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.29918
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.29593
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.29474
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1 2.27867
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, EGFR, GAA, HIF1A, INSR, PDE5A, PIK3CA, PTGS2, SLC5A1, SRC, TEK, TYR 2.2734
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, EGFR, ESR1, F10, FABP3, FUCA1, GAA, HIF1A, HSPA1A, MCL1, MGAM, MMP12, MMP9, PPARA, SLC5A1, SLC5A2, SLC5A4, SRC, TERT, TNKS, TNKS2, XDH 2.27286
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.27286
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, TERT, TNKS 2.27286
[BP] GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand BCL2, HSPA1A, MCL1, TERT 2.26825
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, GPR35, MAOB, MMP9, PTGS2 2.26719
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, EGFR, PTGS2, SRC, TEK 2.25178
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.24936
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOB, MCL1, MET, MMP12, MMP9, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.24906
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.23937
[BP] GO:0060760 None AXL, HIF1A, HSPA1A, MMP12 2.23937
[BP] GO:1901214 regulation of neuron death AXL, BCL2, GBA, HIF1A, MCL1, PIK3CA, PPARA, TERT 2.23937
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.22855
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, GBA, HIF1A, HSPA1A, MCL1, MMP9, NUAK1, PTGS2, PTPN1, SRC, TERT, TOP2A 2.22271
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, HIF1A, IGF1R, INSR, KDR, MCL1, MET, MMP2, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 2.20538
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.19213
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.19213
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.1748
[BP] GO:1901361 None CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DAO, HSPA1A, MAOB, PDE5A, XDH 2.15579
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, EGFR, F10, FABP3, FUCA1, GAA, HIF1A, HSPA1A, MCL1, MGAM, MMP12, MMP9, PPARA, SLC5A1, SLC5A2, SLC5A4, SRC, TERT, TNKS, XDH 2.15017
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.14795
[BP] GO:0010632 regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 2.14795
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.14556
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.09259
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, HIF1A, KDR, PTGS2, TEK, TERT 2.09259
[BP] GO:0005975 None AKR1B1, ALDH2, FUCA1, FUT7, GAA, GLO1, INSR, MGAM, PIK3CA, SLC5A2 2.09259
[BP] GO:0098908 None GBA, GPR35 2.09259
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.09259
[BP] GO:0070213 None TNKS, TNKS2 2.09259
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.09259
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, FLT3, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.09259
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, FABP3, GBA, HIF1A, IGF1R, INSR, MET, MMP12, PHF8, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.08238
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.07368
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.06933
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.06912
[BP] GO:0009888 tissue development ALOX15, ALPL, CYP1B1, GAA, INSR, KDR, PIK3CA, PPARA, PTGS2, RORC, SMAD3 2.04878
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.04878
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.04878
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, PTGS2 2.04878
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, PTGS2 2.04878
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.03935
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.03935
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.03935
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.03935
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, APP, AXL, BCL2, CDK6, EGFR, GBA, GPR35, HIF1A, PDE5A, PTGS2, PTPRS, SMAD3, TEK, TERT, XDH 2.03192
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, HIF1A, PIK3CB, SMAD3 2.02768
[BP] GO:0090257 None ADORA1, CHRM1, CHRM2, CHRM3, PDE5A, PTGS2, SMAD3 2.02768
[BP] GO:0035428 None SLC5A1, SLC5A2, SLC5A4 2.02768
[BP] GO:0060969 None ESR1, PHF8, TERT 2.02768
[BP] GO:1904659 None SLC5A1, SLC5A2, SLC5A4 2.02768
[BP] GO:1902895 None HIF1A, SMAD3, TERT 2.02768
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.02768
[BP] GO:1905950 None SLC5A1, SLC5A2, SLC5A4 2.02768
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.02768
[BP] GO:0051052 regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PIK3CA, SRC, TNKS, TNKS2 2.02768
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, GBA, HIF1A, MCL1, PTGS2, SRC 2.02423
[BP] GO:0006937 None ADORA1, CHRM1, CHRM2, CHRM3, PDE5A, PTGS2 2.02423
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway BCL2, HSPA1A, MCL1, SRC, TERT 2.0147
[BP] GO:0010506 regulation of autophagy BCL2, GBA, HIF1A, KDR, MCL1, MET, PIK3CA, PIK3CB 2.01056
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.00933
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, CHRM1, EGFR, HCAR2, HIF1A, MMP12, PTGS2, SMAD3, SRC 2.00615
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, EGFR, ESR1, F10, FLT3, FUT7, GAA, GBA, GLO1, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOB, MCL1, MET, MGAM, MMP2, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR 4.22949
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOB, MCL1, MGAM, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.6467
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOB, MCL1, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PHF8, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC5A1, SLC5A2, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 3.49073
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, ESR1, F10, FLT3, GAA, GLO1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, PTPRS, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TERT 3.40986
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, CHRM1, CHRM2, CHRM3, CHRM5, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SLC5A1, SLC5A2, SLC5A4, TEK 3.2487
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DUSP3, EGFR, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, MGAM, PTGS2, PTPRS, SLC5A1, SLC5A2, SLC5A4, SRC, TEK 2.9102
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOB, MCL1, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PHF8, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC5A1, SLC5A2, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.84018
[CC] GO:0070062 None ABCB1, AKR1B1, AKR1B10, ALDH2, ALPL, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MAOB, MGAM, MMP9, NQO2, PTGS1, PTPRS, SLC5A1, SLC5A2, SRC, TUBB3 2.6686
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SLC5A1, SLC5A2, SLC5A4, TEK 2.59296
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, INSR, MET, MGAM, PTGS2, SRC, TEK 2.48641
[CC] GO:1903561 None ABCB1, AKR1B1, AKR1B10, ALDH2, ALPL, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MAOB, MGAM, MMP9, NQO2, PTGS1, PTPRS, SLC5A1, SLC5A2, SRC, TUBB3 2.48641
[CC] GO:0043230 None ABCB1, AKR1B1, AKR1B10, ALDH2, ALPL, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MAOB, MGAM, MMP9, NQO2, PTGS1, PTPRS, SLC5A1, SLC5A2, SRC, TUBB3 2.48641
[CC] GO:0031974 None ALDH2, ALOX5, APP, BACE1, CA5A, CA5B, DAO, EGFR, F10, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MCL1, MMP9, PTGS2 2.48276
[CC] GO:0043233 None ALDH2, ALOX5, APP, BACE1, CA5A, CA5B, DAO, EGFR, F10, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MCL1, MMP9, PTGS2 2.48276
[CC] GO:0070013 None ALDH2, ALOX5, APP, BACE1, CA5A, CA5B, DAO, EGFR, F10, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MCL1, MMP9, PTGS2 2.48276
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOB, MCL1, MET, MGAM, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, PTPRS, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TYR 2.46258
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, TEK 2.44663
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HCAR2, HIF1A, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MCL1, MET, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC5A1, SLC5A2, SLC5A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.37631
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, F10, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 2.19315
[CC] GO:0031982 None ABCB1, AKR1B1, AKR1B10, ALDH2, ALPL, APP, AXL, BACE1, CA1, CA2, CA4, CA6, CBR1, DUSP3, EGFR, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, KDR, MAOB, MGAM, MMP9, NQO2, PTGS1, PTPN1, PTPRS, SLC5A1, SLC5A2, SRC, TUBB3, TYR 2.18172
[CC] GO:0031090 None ALOX5, APP, BACE1, BCL2, CA4, CHRM2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, EGFR, FUT7, GAA, GBA, INSR, MAOB, MCL1, MGAM, PHF8, PTGS1, PTGS2, SMAD3, SRC, TNKS, TNKS2, TYR 2.16485
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.10457
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.09259
[CC] GO:0044446 intracellular organelle part AKR1B1, ALDH2, ALOX5, APEX1, APP, AURKB, BACE1, BCL2, CA4, CA5A, CA5B, CA9, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FLT3, FUCA1, FUT7, GAA, GBA, HIF1A, HSD11B1, HSD17B2, HSPA1A, INSR, MAOB, MCL1, MGAM, MMP9, NQO2, NUAK1, PHF8, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR 2.03554
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DNMT1, DUSP3, DYRK1A, EGFR, F10, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 21.6293
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PPARA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 16.4571
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.6857
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DNMT1, DYRK1A, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 13.1769
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, HSD11B1, HSD17B1, HSD17B2, MAOB, NQO2, PHF8, PTGS1, PTGS2, TYR, XDH 10.1867
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.60763
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.49881
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PPARA, PTPN1, RORC, SMAD3, TNKS 8.52337
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 7.51037
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK, TOP2A 7.28692
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, ESR1, ESR2, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE5A, PHF8, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.00596
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.00596
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PHF8, PTGS1, PTGS2, TYR 6.66472
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PHF8, XDH 6.53767
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.39455
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC 6.34067
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.25699
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, ESR1, ESR2, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE5A, PHF8, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.1862
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC 6.07902
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 5.99223
[MF] GO:0048037 cofactor binding ALDH2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, HSD17B1, MAOB, NQO2, PTGS1, PTGS2, SRC, XDH 5.93155
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.69656
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 5.12357
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.11012
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 4.67566
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.42869
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.35548
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NQO2 4.31603
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, ALDH2, AURKB, AXL, CDK6, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 4.20229
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.03764
[MF] GO:0000166 nucleotide binding ABCB1, ALDH2, AURKB, AXL, CDK6, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 4.03442
[MF] GO:1901265 nucleoside phosphate binding ABCB1, ALDH2, AURKB, AXL, CDK6, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 4.03442
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 3.92535
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, CYP19A1, CYP1A2, MAOB, NQO2, XDH 3.71223
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CDK6, CSNK2A1, DAO, DYRK1A, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TEK, TOP2A, TUBB3, XDH 3.64696
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.62265
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.61007
[MF] GO:0005412 None SLC5A1, SLC5A2, SLC5A4 3.52256
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PDE5A, PTPN1, PTPRS 3.44819
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT 3.32119
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 3.15756
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5, PDE5A 3.11542
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 2.99987
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 2.99987
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 2.85492
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.71001
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.69043
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.69043
[MF] GO:0008389 None CYP2A13, CYP2A6 2.69043
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MAOB, MCL1, MET, MMP9, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH 2.66733
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PDE5A, PTPN1, PTPRS 2.57074
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 2.57074
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HCAR2, HIF1A, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC5A1, SLC5A2, SLC5A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.57074
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.50389
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 2.45988
[MF] GO:0016787 None ABCB1, ACHE, ADORA1, ALOX15, ALPL, APEX1, BACE1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, F10, FUCA1, GAA, GBA, HSPA1A, MGAM, MMP1, MMP12, MMP2, MMP9, PDE5A, PTPN1, PTPRS, TOP2A, TUBB3 2.44461
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, ALDH2, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FLT3, HIF1A, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TUBB3, XDH 2.42203
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 2.38924
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.37728
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.3646
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.32909
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.32909
[MF] GO:0032450 None GAA, MGAM 2.32909
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, XDH 2.32776
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, PTPRS, SRC, TEK 2.31217
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, HSD17B1, RORC 2.29918
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.2734
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ALDH2, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FLT3, HIF1A, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TUBB3, XDH 2.27286
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.24622
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TEK, TOP2A, TUBB3 2.22967
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, PHF8, PTGS1, PTGS2 2.22855
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, RORC 2.18062
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, RORC 2.18062
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.14291
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.11422
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.09259
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.09259
[MF] GO:0051425 None APP, INSR 2.09259
[MF] GO:0004558 None GAA, MGAM 2.09259
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.09259
[MF] GO:0005355 None SLC5A1, SLC5A2, SLC5A4 2.06912
[MF] GO:0015149 None SLC5A1, SLC5A2, SLC5A4 2.02768


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.6249
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.5402
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, MAOB, ALOX15, GBA, AKR1B1, PTGS2, CYP3A4, CYP19A1, PTGS1, HSD11B1, FUT7, ALDH2, ALOX5, HSD17B1, HSD17B2, XDH, CBR1, MGAM, GAA, TYR, CYP2A6, DAO, AKR1B10, CYP1A2, CYP1A1, ALPL 7.8309
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.2662
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.8309
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.738
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, PTGS2, MMP9, EGFR, CDC25B, CDK6, PIK3CA, BCL2, PIM1, CYP1B1, MET, MCL1 7.1266
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, HIF1A, EGFR, IGF1R 6.9266
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, HIF1A, EGFR, IGF1R, CDK6, PIK3CA, BCL2, MET 6.7055
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.1266
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, PIK3CB, EGFR, IGF1R, CDK6, PIK3CA, KDR, BCL2, TEK, MET, MCL1 6.6098
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.1266
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.7055
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, BCL2, PIK3CB 5.9481
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, HIF1A, EGFR, IGF1R 6.1726
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.8969
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, HIF1A, EGFR 4.8969
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.8187
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.1466
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 4.1295
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.0261
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB, EGFR 4.0197
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 3.9281
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, MAOB, CYP1A2, CYP1A1, CYP1B1 4.8058
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.7724
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, EGFR, IGF1R 3.9281
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOB, ALOX5, ALOX15, PTGS2, PTGS1 3.908
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 3.945
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA 3.46
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 3.9974
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.5133
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 3.9223
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.7642
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.3809
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PDE5A, PIK3CB 3.0489
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.4291
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.8847
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.0085
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1, HIF1A 2.8871
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 2.8871
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, GPR35, ADORA3, CHRM5, ADORA1 2.7721
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 2.8804
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB, EGFR 3.0726
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.0534
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.6887
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 2.9427
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB, MCL1 2.44
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.44
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 2.8871
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET, HIF1A 2.8847
Galactose metabolism_Homo sapiens_hsa00052 MGAM, AKR1B10, GAA, AKR1B1 3.9974
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, EGFR 2.237
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 2.7721
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.52
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.3609
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, CYP1A2, CYP3A4 2.8413
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 MGAM, PIK3CA, SLC5A1, PIK3CB 3.4237
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.421
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, HIF1A, EGFR 2.3259
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.0687
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.6815
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.2217
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8413
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, SLC5A1, CYP3A4 2.8055
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.0772
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.1174
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB, MCL1 1.909
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.0687
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 1.9718
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 1.9147
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 1.8928
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2149
Alcoholism_Homo sapiens_hsa05034 MAOB 0.2212
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 1.8817
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.8202
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2606
Phagosome_Homo sapiens_hsa04145 TUBB3 0.2606
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.584
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.297
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.4246
Axon guidance_Homo sapiens_hsa04360 MET 0.3086
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.1502
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB 0.3062
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3161
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB 1.1388
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1115
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.1598
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.5672
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.5569
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.5672
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.0177
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5566
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3775
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3775
Lysosome_Homo sapiens_hsa04142 FUCA1, GAA, GBA 1.3512
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6728
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.3746
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 0.9606
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6615
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.3775
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.6934
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.6863
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3906
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.3463
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.5832
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.6474
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4027
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.52
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4078
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4078
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4078
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.4166
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.415
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.8271
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4078
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4134
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.8374
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.6315
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.8626
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 0.902
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, EGFR 1.6819
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.8739
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.8857
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.4313
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4377
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9226
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4541
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4666
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.469
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.477
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 0.9722
Shigellosis_Homo sapiens_hsa05131 SRC 0.4827
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4856
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB, HIF1A 2.0754
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.0591
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.477
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.0526
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5067
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.95
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.1063
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.0768
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.0845
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.2231
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5366
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5366
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1336
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.5521
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5566
Malaria_Homo sapiens_hsa05144 MET 0.5602
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.5602
Mineral absorption_Homo sapiens_hsa04978 SLC5A1 0.5566
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO, ALDH2, MAOB 2.2596
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5672
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2 0.5621
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.3044
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA 0.5672
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5774
Starch and sucrose metabolism_Homo sapiens_hsa00500 MGAM, GAA 1.2349
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.5719
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.52
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.5774
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.345
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6609
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6934
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7357
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6749
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.8413
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.608
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.6934
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO, MAOB 1.4862
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7406
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2, GLO1 1.4862
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6966
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7357
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.7357
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, TYR 1.5832
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6392
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8891
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.8941
Histidine metabolism_Homo sapiens_hsa00340 ALDH2, MAOB 1.863
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9606
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.8969
Other glycan degradation_Homo sapiens_hsa00511 FUCA1, GBA 2.0687


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)