TCM Prescription: Liu Yu Pills



Prescription Description
Prescription IDTCMF4586
Pinyin NameLiu Yu Wan
Chinese Name六郁丸
English NameLiu Yu Pills
Function Description郁病
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH2693 Fructus gleditsiae abnormalis 猪牙皂 TCMH2693
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH1662 Pharbitis nil 牵牛子 TCMH1662
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1305 Salmonella enteritidis
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7709
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7709
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, MAOA, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 14.8074
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, IGF1R, MMP2, MMP9, MPO, PIK3CA, PPARA, PTGES, PTGS2, RELA, SRC, TYR 13.7533
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, MPO, PTGES, PTGS2, RELA, SRC, TYR 13.015
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KDR, MMP2, MMP9, MPO, PIK3CA, PPARA, PTGES, PTGS2, RELA, SRC, TYR 12.4896
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 11.9082
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 11.383
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 11.3507
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, IGF1R, KDR, MMP2, MPO, PIK3CA, PPARA, PTGES, PTGS2, RELA, SRC, TYR 11.1825
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GBA2, HMGCR, HSD17B3, HTR2B, HTR2C, IDO1, MPO, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR, XDH 10.9245
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 10.8521
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, IDO1, IGF1R, KDR, MAP2K1, MMP12, MMP2, MMP9, PIM1, PTGES, PTGS1, PTGS2, RELA, SRC, XDH 10.7903
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 10.2447
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, CNR1, DRD1, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 9.97184
[BP] GO:0097756 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 9.79327
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRB, F3, FABP4, HMGCR, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, RELA, SRC, TNKS2, TYR 9.51736
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2C 9.49958
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, PTGES, PTGS2, RELA, SRC, TYR 9.4239
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 9.32609
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, MPO, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 9.30386
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 8.80182
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 8.71437
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F3, FLT3, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 8.6714
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F3, FLT3, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 8.49218
[BP] GO:0042493 response to drug ABCG2, AKR1B1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, FABP3, HMGCR, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PTGS2, RELA, SRC 8.48353
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 8.34739
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TYR 8.26769
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, IDO1, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 8.19775
[BP] GO:0003018 None ADORA1, CHRM1, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 8.19719
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 8.17293
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HMGCR, HTR2B, IDO1, IGF1R, KDR, MAP2K1, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 8.09499
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HMGCR, HTR2B, IDO1, IGF1R, KDR, MAP2K1, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, XDH 8.02605
[BP] GO:0097746 None ADORA1, CHRM1, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.02071
[BP] GO:0035296 None ADORA1, CHRM1, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.02071
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, F3, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, RELA 7.86628
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2 7.84344
[BP] GO:0050880 None ADORA1, CHRM1, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.75409
[BP] GO:0035150 None ADORA1, CHRM1, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.72563
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HMGCR, HTR2B, IDO1, IGF1R, KDR, MAP2K1, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 7.55322
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.4184
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, KDR, MAP2K1, MET, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, TNKS2, TYR 7.28138
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, GBA2, HMGCR, HSD17B3, HTR1A, MAOA, TYR 7.24554
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 7.23313
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 7.17267
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC 7.05841
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 7.03233
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 7.03141
[BP] GO:0003013 None ADORA1, CHRM1, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 6.96452
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, ESR1, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 6.96401
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2, RELA, SRC 6.92818
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 6.91294
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, ESRRB, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.90497
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, ESRRB, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.90497
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.83627
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.80086
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 6.70865
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGES, PTGS2, RELA, SRC 6.65486
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC 6.62133
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC 6.55998
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, HMGCR, HTR1B, HTR1D, KDR, RELA, SRC 6.55998
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 6.55256
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 6.53642
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.37567
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.35411
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, PIK3CA, PPARA, RELA, SRC, TYR 6.34023
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 6.32276
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, ESRRB, FABP3, FABP4, FLT3, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 6.29251
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, CNR1, DRD1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.26274
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, CNR1, DRD1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.26274
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, ESRRB, FABP3, FABP4, FLT3, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 6.22563
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HMGCR, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 6.2158
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 6.20215
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 6.11858
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.98235
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, HTR2B, IDO1, IGF1R, KDR, MMP9, MPO, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC 5.98235
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 5.98235
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 5.98104
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.9713
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, HTR2A, HTR2B, HTR2C, KDR, SRC 5.91934
[BP] GO:0007154 None ADORA1, AR, AXL, BCL2, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, DRD1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 5.88538
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B 5.73441
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, ESRRB, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 5.73441
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, DRD1, ESR1, HTR2A, HTR2B, HTR2C 5.70136
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGES, PTGS2, RELA, SRC 5.68372
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.67505
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, HTR5A, KDR, MAP2K1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SRC, TYR 5.58155
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, SRC 5.58015
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, DRD1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.4543
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, DRD1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.4543
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.44661
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGES, PTGS2, RELA, SRC 5.39583
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 5.36422
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, HTR1B, HTR2A, PTGS2 5.34009
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.34009
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, IDO1, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, RELA, SRC, TNKS2, XDH 5.33072
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 5.27292
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.21589
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 5.21589
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 5.16897
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CHRM1, CNR1, CYP19A1, DRD1, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MAP2K1, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 5.15538
[BP] GO:0023052 None ADORA1, AR, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, DRD1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.12631
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 5.07842
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.00851
[BP] GO:0007267 None ADORA1, AR, CHRM1, CHRM2, CHRM4, CNR1, DRD1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.00703
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 4.98562
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 4.97338
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 4.97338
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, HMGCR, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, MPO, PPARA, PTGS2, RELA, SRC, TYR 4.96067
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RELA, SRC 4.92495
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, HTR1A, MAP2K1, MET, PIK3CB, PIM1, SRC, TYR 4.77446
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.75931
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, RELA, SRC 4.75097
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC, TNKS 4.74845
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, SRC 4.73938
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HMGCR, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.71888
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 4.71316
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 4.71057
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RELA, SRC 4.69299
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 4.66091
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.6565
[BP] GO:0019371 None PTGES, PTGS1, PTGS2, TBXAS1 4.63553
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 4.61791
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HMGCR, HTR2A, MAP2K1, MPO, PTGS2, RELA 4.57867
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.55225
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 4.53973
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.53368
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD17B3, IDO1, MPO, PTGES, PTGS1, PTGS2 4.53368
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MAP2K1, MET, MMP12, PPARA, PTGS2, RELA 4.50746
[BP] GO:0090066 None ADORA1, ALOX15, CHRM1, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.49019
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD1, HTR1B, HTR2A, PTGS2 4.48203
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD1, HTR1B, HTR2A, PTGS2 4.48203
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HCAR2, HMGCR, HTR2A, HTR2B, IDO1, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, PTGS2, RELA, SRC 4.4742
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD1, F3, HTR1D, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.43717
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.39993
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.39993
[BP] GO:0065007 biological regulation ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.39223
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HMGCR, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.37454
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.33009
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, HTR1B, HTR2A, PTGS2 4.29221
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.27635
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, HMGCR, IDO1, IGF1R, MAP2K1, MAP3K7, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC, XDH 4.26743
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, IDO1, MAP2K1, MMP2, MMP9, PTGS2, SRC 4.22101
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, SRC 4.20845
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, ESR1, F3, FLT3, FUT7, GBA2, HMGCR, HTR1A, HTR2B, HTR2C, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TYR, XDH 4.16783
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 4.15844
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 4.12181
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.11053
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC, TYR 4.01512
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 4.01179
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 3.98525
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, MPO, PTGS1, PTGS2, RELA, SRC 3.97892
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, PTPN1, SRC 3.97892
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 3.97892
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGES, PTGS1, PTGS2 3.97563
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, ESR1, F3, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, XDH 3.96036
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESR1, F3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.96036
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, HSD17B3, IDO1 3.93246
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.93188
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.93188
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, HTR1B, KDR, PTGS2, RELA, SRC 3.8882
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, MPO, PTGS2, RELA, SRC, TYR 3.85626
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 3.83478
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CACNA1C, CHRM1, CNR1, DRD1, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 3.79245
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, IDO1, MAOA, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CB, SRC, XDH 3.7298
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGES, PTGS2, RELA, SRC 3.71065
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, HTR1B, MMP2, MMP9, PTGS2 3.70371
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.65233
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.65233
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, HTR1A, MAOA, TYR 3.64497
[BP] GO:0007610 None APP, BCL2, CNR1, DRD1, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IDO1, PPARA, PTGS2 3.6395
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC, TYR 3.63502
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, BCL2, CDK6, CNR1, CNR2, CYP19A1, DRD1, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, SRC, XDH 3.63295
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, HSD11B2, HTR1A, HTR2C, IDO1, MAP2K1, MAP3K7, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC 3.63295
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CHRM1, CNR1, CNR2, CYP1B1, DRD1, HMGCR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2, SRC, TYR 3.54275
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGES, PTGS2, RELA, SRC 3.49743
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.48879
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HMGCR, HSD11B2, HTR2A, IDO1, MMP12, MPO, PTGES, PTGS2, RELA, SRC, TYR 3.48175
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, CNR2, DRD1, ESR1, ESR2, HMGCR, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 3.47985
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.47947
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, CNR2, DRD1, ESR1, ESR2, HMGCR, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 3.46662
[BP] GO:0006939 None DRD1, HTR1D, HTR2A, HTR2B, HTR7 3.46662
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, HCAR2, IDO1, MAP3K7, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, RELA, SRC 3.46081
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES, PTGS2 3.46081
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CDK6, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RELA, SRC 3.45306
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.45306
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2B, HTR2C, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 3.45306
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, MPO, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 3.41129
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, MPO, PTGS2, RELA, SRC, TYR 3.37158
[BP] GO:0050801 ion homeostasis ABCG2, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 3.37158
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.32853
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.32853
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HCAR2, HTR2B, MET, PIK3CA, PPARA, RELA 3.29139
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CNR1, CYP19A1, HCAR2, HMGCR, HTR1A, HTR2A, HTR2C 3.29139
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, SRC 3.2848
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 3.28214
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 3.28214
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RELA, SRC 3.28214
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 3.28214
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, MAP3K7, MMP12, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC 3.24852
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, HTR2C, IDO1 3.24852
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 3.23744
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.2309
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, SRC 3.21949
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.21949
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, MAP2K1, PTGS2, SRC 3.21539
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, ESR1, ESR2, F3, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, XDH 3.21474
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HCAR2, HMGCR, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 3.17385
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 3.16098
[BP] GO:0008217 None ADORA1, AR, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 3.1516
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, DRD1, HTR1A, HTR2C, MPO, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA, SRC 3.1516
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, PTGS2, SRC 3.1516
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTPN1, RELA, SRC, TNKS, XDH 3.12795
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, ESRRB, HCAR2, HTR2A, HTR2B, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PPARA, PTPN1, RELA 3.12795
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA 3.12795
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, CHRM1, CNR1, HCAR2, HMGCR, HTR2B, HTR2C, MMP12, PTGS2, PTPN1, SRC 3.11619
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1, HSD17B3 3.09925
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, IDO1, MAOA, MPO 3.08342
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HMGCR, HTR2A, HTR2C, IDO1, KDR, MAP2K1, PIM1, PTGS2, RELA, SRC 3.08116
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.05675
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.05629
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGES, PTGS1, PTGS2 3.04409
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.02713
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.99298
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 2.99259
[BP] GO:0002209 None BCL2, DRD1, HTR1A, HTR2C 2.99259
[BP] GO:0001662 None BCL2, DRD1, HTR1A, HTR2C 2.99259
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, SRC 2.98687
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, MPO, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.95687
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.94993
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, CYP3A4, HMGCR, HSD17B3, TYR 2.94993
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 2.94817
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.94817
[BP] GO:0098771 inorganic ion homeostasis ABCG2, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.94647
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.9451
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 2.9451
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.92267
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MET, MMP12, PPARA, PTGS2, RELA, SRC, TNKS, TNKS2 2.91573
[BP] GO:0042596 None BCL2, DRD1, HTR1A, HTR2C 2.89536
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.8831
[BP] GO:0055082 cellular chemical homeostasis ABCG2, APP, BCL2, CA2, CA7, CACNA1C, DRD1, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.8831
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.8831
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.87462
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1 2.83421
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, PPARA, PTGS2, RELA 2.83341
[BP] GO:0030003 cellular cation homeostasis ABCG2, APP, BCL2, CA2, CA7, CACNA1C, DRD1, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.823
[BP] GO:0007208 None HTR2A, HTR2C 2.78815
[BP] GO:0009115 None AOX1, XDH 2.78815
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 2.78467
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.77858
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, HTR2A, MET, PIK3CA 2.76424
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, PIK3CA, RELA, TYR 2.76231
[BP] GO:0006873 cellular ion homeostasis ABCG2, APP, BCL2, CA2, CA7, CACNA1C, DRD1, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.73405
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.72956
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, PTGS2 2.70921
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, RELA, SRC 2.70623
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.69545
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.6833
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.6833
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.6833
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, HTR1A, MAOA 2.67802
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.65922
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 2.64257
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.64017
[BP] GO:0051952 None ADORA1, CNR1, DRD1, HTR1B, HTR2A 2.6341
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 2.6341
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.62672
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, FUT7, HTR2B, HTR6, KDR, MAP2K1, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.6169
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CDK6, CYP1B1, FABP3, IDO1, MAP2K1, PTGES, PTGS2, XDH 2.59738
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.59606
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.59606
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, HTR1B, MMP2, MMP9, PTGS2 2.59606
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, FUT7, HTR2B, HTR6, KDR, MAP2K1, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.59201
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.59126
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, MAP2K1, MET, MMP12, PPARA, PTGS2, RELA, SRC, TNKS, TNKS2 2.58739
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.58739
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, XDH 2.57693
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.5652
[BP] GO:1901570 None ALOX15, ALOX5, PTGES, PTGS1, PTGS2 2.54496
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.54482
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, HMGCR, PTGS2, RELA, TYR 2.54333
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, XDH 2.54311
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.50451
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.50451
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, PIK3CB 2.5018
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, RELA, TYR 2.5018
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.49327
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, RELA, SRC 2.4799
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.4642
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 2.46317
[BP] GO:0050890 None ADORA1, APP, CHRM1, CNR1, DRD1, HMGCR, HTR2A, PTGS2 2.4581
[BP] GO:0055080 cation homeostasis ABCG2, APP, BCL2, CA2, CA7, CACNA1C, DRD1, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.45555
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.4441
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.4441
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.4441
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.4441
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.43297
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.40037
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 2.3979
[BP] GO:0046110 None AOX1, XDH 2.38934
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38934
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.37281
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, F3, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 2.36699
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, CNR1, HCAR2, HMGCR, HTR2B, HTR2C, MMP12, SRC 2.36601
[BP] GO:2001023 None CNR1, DRD1, HTR1B, HTR2A, MET 2.36037
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.35557
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, HMGCR, PTGS2, RELA, TYR 2.34058
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC, XDH 2.33984
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTGS2, PTPN1, RELA, SRC 2.33984
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.32646
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 2.32126
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.31078
[BP] GO:0014821 None DRD1, HTR1D, HTR2B 2.31078
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX15, CYP1A1, IDO1, PTGES, PTGS1, PTGS2 2.3066
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.3066
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.2987
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.29302
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.28935
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, XDH 2.28487
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC 2.24922
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.24854
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.24854
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.24377
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CACNA1C, DRD1, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.24056
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.21285
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.18439
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, MAP3K7, PIM1, RELA 2.18402
[BP] GO:0019725 cellular homeostasis ABCG2, APP, BCL2, CA2, CA7, CACNA1C, DRD1, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.18393
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, HMGCR, HTR2A, HTR2C, IDO1, KDR, MAP2K1, PIK3CA, PIM1, PPARA, PTGS2, RELA, SRC, TNKS2, XDH 2.17037
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, DRD1, ESR1, FLT3, HTR1B, IGF1R, MMP2, PTGS2, RELA, SRC 2.16424
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.15717
[BP] GO:0006875 cellular metal ion homeostasis ABCG2, APP, BCL2, CACNA1C, DRD1, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.15104
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CACNA1C, DRD1, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.14946
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.14595
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, HTR1B, IGF1R, MMP2, PTGS2, RELA, SRC 2.14595
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.14595
[BP] GO:0070213 None TNKS, TNKS2 2.14595
[BP] GO:0006145 None AOX1, XDH 2.14595
[BP] GO:0038171 None CNR1, CNR2 2.14595
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.14595
[BP] GO:0014827 None HTR1D, HTR2B 2.14595
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.14595
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DRD1, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTPN1, RELA, SRC 2.14595
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.14595
[BP] GO:0032094 None CYP1A1, HSD11B2, MPO 2.14595
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.14595
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CACNA1C, CHRM1, CNR1, CSNK2A1, HCAR2, HMGCR, HTR2B, MMP12, PTGS2, PTPN1, SRC 2.13844
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MPO 2.13546
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, CACNA1C, DRD1, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.12841
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.1175
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, CNR1, CNR2, DRD1, KDR, SRC 2.11408
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.09169
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.09169
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.09169
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, IDO1, MMP12 2.06966
[BP] GO:0046890 None FABP3, HMGCR, HTR2A, HTR2B, HTR2C, PTGS2 2.06841
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, F3, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TNKS, XDH 2.0643
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.04765
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.04026
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.04026
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.04026
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.04026
[BP] GO:0070201 None ACHE, APP, BCL2, CACNA1C, CHRM1, CNR1, HCAR2, HMGCR, HTR2B, MMP12, PTGS2, PTPN1, SRC 2.02239
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.01321
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.0085
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR 7.69556
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 6.53642
[CC] GO:0044425 membrane part ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MPEG1, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TYR 6.48867
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, DRD1, ESR1, F3, FLT3, GBA2, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC 6.47317
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.67505
[CC] GO:0044459 plasma membrane part ABCG2, ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTGS2, SRC 5.01511
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, TBXAS1 3.65299
[CC] GO:0031224 None ABCG2, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP3A4, DRD1, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MPEG1, PTGES, TBXAS1, TYR 3.4719
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, PTPN1, TBXAS1 3.45877
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.27327
[CC] GO:0016021 None ABCG2, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP3A4, DRD1, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MPEG1, PTGES, TBXAS1, TYR 3.10513
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2A, HTR4, HTR5A, IDO1, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 2.85877
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, FLT3, GBA2, HMGCR, HSD17B3, HTR5A, KDR, MAP2K1, PTGS2, PTPN1, XDH 2.48419
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CNR1, CNR2, DRD1, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, SRC 2.0108
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.4675
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.9001
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7709
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7709
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 15.7709
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 15.7709
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 14.5282
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, DRD1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.983
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TYR, XDH 13.3353
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, MPO, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 11.0438
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA 10.5101
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.2665
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.2448
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.59965
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA 9.57973
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, PPARA 9.55717
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 9.46757
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA 9.27626
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 9.09248
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B2, HSD17B1, IDO1, MPO, NQO2, PTGES, PTGS1, PTGS2, SRC, TBXAS1, XDH 8.07512
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, MPO, PTGS1, PTGS2, SRC, TBXAS1 7.87745
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, MPO, PTGS1, PTGS2, SRC, TBXAS1 7.56541
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC 7.54512
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 7.20098
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 7.20098
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, SHBG 6.96292
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.51088
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, XDH 5.90984
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 5.8724
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.75381
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, TNKS 5.63664
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, TBXAS1, TYR 4.97338
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.92495
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 4.91349
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.74776
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 4.71316
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 4.71316
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.6788
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.60467
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.46797
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 4.29592
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 4.29221
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, IDO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 4.23096
[MF] GO:0097159 organic cyclic compound binding ABCG2, ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RELA, SHBG, SRC, TBXAS1, XDH 4.15844
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.96174
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, SHBG 3.96174
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.93188
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.5896
[MF] GO:1901363 heterocyclic compound binding ABCG2, ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, XDH 3.49428
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NQO2, SHBG 3.45939
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.21199
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.1516
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.12795
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 2.9938
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.8831
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC 2.8831
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.78815
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.78815
[MF] GO:0003845 None HSD11B1, HSD11B2 2.78815
[MF] GO:0071886 None HTR2A, HTR2C 2.78815
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC 2.71182
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.68811
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 2.65028
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.56885
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.4292
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.38934
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.38934
[MF] GO:0004949 None CNR1, CNR2 2.38934
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC 2.36601
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, IDO1, PTGS1, PTGS2 2.34058
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.31078
[MF] GO:0043168 anion binding ABCG2, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, RELA, SRC, XDH 2.3066
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SRC 2.29506
[MF] GO:0042802 identical protein binding ABCG2, ACHE, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MAP3K7, MET, MMP9, NQO2, PTGS2, RELA, TYR, XDH 2.24056
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SRC 2.15104
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.14595
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.14595
[MF] GO:0005497 None AR, SHBG 2.14595
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.14595


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, HTR1E, MAOA, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, CACNA1C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 21.7071
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, MAP2K1, CHRM1, HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C, PIK3CB, HTR4, RELA, HCAR2, HTR6, PIK3CA, ADORA1, DRD1, PPARA 14.4309
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, HTR1E, CHRM4, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1, DRD1 14.4309
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 11.1409
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.5669
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, HSD17B3, AKR1B1, HMGCR, PTGS2, CYP3A4, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, ALOX5, HSD17B1, HSD17B2, AOX1, XDH, TYR, AKR1B10, TBXAS1, CYP1A2, CYP1A1, ALPL, PTGES, IDO1 7.9559
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, CHRM1, HTR2B, HTR2C, CACNA1C, HTR2A, DRD1, HTR5A, HTR4 7.6621
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, MAP2K1, CHRM1, PIK3CA, CHRM4, BCL2, CACNA1C, PIK3CB 7.2317
Pathways in cancer_Homo sapiens_hsa05200 MAP2K1, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, RELA, IGF1R, AR, CDK6, PIK3CA, BCL2, MET 6.9838
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.5183
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 6.4088
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.1971
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, ESR2, RELA 6.1782
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 5.5666
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 6.2914
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, CDK6, CHRM1, PIK3CA, KDR, BCL2, PIK3CB, MET, RELA, IGF1R 5.2557
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3, RELA 5.3355
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9, RELA 5.3451
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, PIM1, PIK3CB, RELA 5.4953
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.5156
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.3451
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.1229
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, PTGS2, PTGES, PTGS1 5.3451
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.9893
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6, PIK3CA, PIK3CB, MET, IGF1R 5.0719
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB, RELA 4.9535
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 4.9923
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.5031
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, PIK3CA, SRC, CNR1, KDR, PIK3CB, MET, IGF1R 4.3904
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.3904
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, PIK3CA, KDR, PIK3CB, MET, RELA, IGF1R 4.184
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2, RELA 4.6774
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, HTR2B, HTR2C, HTR2A, DRD1 4.6332
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 4.7841
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 4.2895
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, MAP3K7, RELA 4.0097
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 4.9923
Glioma_Homo sapiens_hsa05214 MAP2K1, CDK6, PIK3CA, PIK3CB, IGF1R 4.1422
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA 3.7007
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, MAP2K1, CHRM1, PIK3CA, SRC, CHRM4, PIK3CB 3.5235
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, PIK3CA, PIK3CB, RELA 4.1212
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2 3.3799
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, PIK3CA, PIK3CB, RELA 3.9504
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, PIK3CB, MET 4.1005
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C 3.7007
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PIK3CB, CDC25B, IGF1R 3.3847
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, ADORA1, CACNA1C, PIK3CB 3.2744
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.2809
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.9504
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2, MAP3K7, RELA 3.4835
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.2678
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA, RELA 3.2191
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, RELA, IGF1R 3.1339
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1 3.0899
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.071
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.0522
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, MAP3K7, RELA 2.9543
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, MAP3K7, IGF1R 3.0266
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 2.8438
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 2.9481
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, PIK3CA, ESRRB, PIK3CB, IGF1R 2.8219
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, CDK6, PIK3CA, PIK3CB 3.2744
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.6417
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, PIK3CA, BCL2, PIK3CB 3.1339
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB, RELA 2.1834
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PIK3CA, SRC, PIK3CB, RELA 2.3455
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2449
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2539
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.0696
Phagosome_Homo sapiens_hsa04145 MPO 0.2784
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PIK3CA, PIK3CB, RELA 2.9543
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.3004
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.6424
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.0983
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, PIK3CA, SRC, PIK3CB 2.704
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, RELA 2.0983
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 1.8435
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.0805
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, RELA, IGF1R 2.601
Axon guidance_Homo sapiens_hsa04360 MET 0.3327
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.2648
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA, RELA 1.9416
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1, PIK3CA, PIK3CB 2.0496
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, CACNA1C, PIK3CB 1.9674
Influenza A_Homo sapiens_hsa05164 MAP2K1, PIK3CA, PIK3CB, RELA 1.7338
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.3651
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8589
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1, CYP3A4 3.0234
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2542
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4031
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4192
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7683
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4181
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6336
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB, RELA 0.7844
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4192
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, PIK3CA, PIK3CB 1.2881
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4, ABCG2 2.9893
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1, PIK3CA, PIK3CB 1.3479
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0234
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.433
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.0664
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7442
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4333
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.0999
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.7326
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA, DRD1 1.0975
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.433
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4389
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.4447
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.433
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8002
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C, DRD1 1.3949
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4406
Peroxisome_Homo sapiens_hsa04146 XDH 0.4464
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.8173
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4499
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, PIK3CA, PIK3CB 1.6509
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4464
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4582
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, RELA 1.654
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4563
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1, PIK3CA, PIK3CB 1.7305
Pertussis_Homo sapiens_hsa05133 RELA 0.4698
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB, RELA 1.6251
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.472
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 0.9397
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C, PTGS2 1.6509
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.472
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.9492
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4921
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9983
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0201
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5146
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RELA 0.5116
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 1.9884
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PIK3CB 2.0654
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1149
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C, DRD1 2.0738
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.1757
Legionellosis_Homo sapiens_hsa05134 RELA 0.569
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.0654
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1682
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.1757
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.2147
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.595
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.2317
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5998
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2232
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.2756
Malaria_Homo sapiens_hsa05144 MET 0.6048
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.2756
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6155
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, PIK3CA, PIK3CB 2.3514
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6101
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3013
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2814
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6155
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.6336
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, RELA 2.4207
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.4412
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6672
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7172
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7172
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.4689
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4549
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7749
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.6821
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7542
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.7948
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7749
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8008
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7675
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.0033
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7948
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.8094
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7265
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6449
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8271
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8598
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9751
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9535
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9397
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0247
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3261
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1339


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)