TCM Prescription: Hou Tong Tablets



Prescription Description
Prescription IDTCMF4566
Pinyin NameHou Tong Pian
Chinese Name喉痛片
English NameHou Tong Tablets
Function Description喉痹, 口疮
IndicationsPharyngitis, Aphtha
Disease ICD-11 Category CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
DA01.10 [Oral aphthae or aphtha-like ulceration, 口腔阿弗他溃疡或阿弗他样溃疡 ];
Human Tissues Associated with IndicationLung, Liver, Spleen
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH536 Centipeda minima 鹅不食草 TCMH536 ITSAJ4316-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH547 Catechu 儿茶 TCMH547
TCMH1814 Sophora subprostrata 山豆根 TCMH1814
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH189 Mentholum 薄荷脑 TCMH189
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1184 Mycobacterium fortuitum
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1261 Pseudomonas savastanoi pv. savastanoi
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1394 Mycobacterium aurum
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 8.18667
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.18667
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 7.53843
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.89989
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.82572
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SRC, TYR 6.29241
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, HSD17B2, SRC, TYR 6.21714
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 5.98236
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, PPARA, SRC, TNKS, TNKS2, XDH 5.65275
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, PPARA, SRC, TYR 5.65275
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.65275
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TYR 5.59158
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 5.52901
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 5.47715
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 5.21227
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.94786
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.94462
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 4.94462
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 4.93941
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.9373
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, SRC, TYR 4.9373
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.9251
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, SRC, TYR 4.9059
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 4.9059
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.76283
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, XDH 4.7383
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FUT7, GBA2, PIM1, PPARA, TYR, XDH 4.73317
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, SRC, TYR 4.67782
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.65994
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.54063
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 4.53148
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.44954
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.44954
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TYR 4.39443
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, PPARA, SRC 4.29642
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.29642
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 4.15702
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC 4.14719
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.94375
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1 3.86139
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.85236
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, KDR, SRC, TNKS, TNKS2 3.8447
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.789
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, SRC, XDH 3.76207
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, F3, FLT3, FUT7, GBA2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.68203
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.65292
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC 3.6077
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.60352
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.52432
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.52075
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.4899
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC 3.47164
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.47164
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.44853
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.43735
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.42108
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.3219
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.25796
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC 3.2496
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 3.23744
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.23649
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC 3.16798
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC 3.15798
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC 2.96547
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.92411
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.91975
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.91975
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.89732
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FUT7, GBA2, MET, PPARA 2.86994
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.86871
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.86871
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.86871
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.86871
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP4, GBA2 2.86871
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.86871
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.86871
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, F3, FLT3, KDR, MET, PTPN1, SRC, XDH 2.86871
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 2.86871
[BP] GO:0009115 None AOX1, XDH 2.86871
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.8675
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, SRC 2.83569
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.7682
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.7682
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.7682
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.7682
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.7682
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.74659
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.72374
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.70446
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.70446
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.70446
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.69637
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTPN1, SRC, TYR 2.67545
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.67539
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.6512
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.64402
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.57994
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.57673
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.55071
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.54951
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.52357
[BP] GO:0046110 None AOX1, XDH 2.49394
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.49394
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTPN1, SRC 2.48648
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC 2.48483
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.46905
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 2.46001
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, SRC 2.45541
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, SRC 2.4453
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.44261
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2 2.43737
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.42404
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.36706
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.34991
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.3213
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2 2.27213
[BP] GO:0070213 None TNKS, TNKS2 2.25475
[BP] GO:0006145 None AOX1, XDH 2.25475
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25475
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.2515
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.24712
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.24148
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.23052
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.21814
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.2016
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TYR 2.1864
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.16634
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, SRC 2.16198
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 2.14982
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, XDH 2.14982
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2 2.14626
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.14626
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.13046
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA 2.11134
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.09669
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.09669
[BP] GO:0043696 None CDK6, ESRRB 2.09669
[BP] GO:0043697 None CDK6, ESRRB 2.09669
[BP] GO:0010641 None F3, SRC 2.09669
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, SRC 2.06127
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, MET, MMP2, MMP9, SRC 2.03261
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.03087
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CYP19A1, ESR1, F3, FABP4, IGF1R, MET, MMP2, PPARA, PTPN1, SRC, XDH 2.03087
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, SRC, TNKS 2.01418
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.10772
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.96166
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR 1.81751
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, IGF1R, KDR, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 1.55169
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 1.45344
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 12.1818
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 10.492
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.18667
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 7.53843
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS 5.65275
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.53314
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.40646
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.20641
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.60011
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 4.53148
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.31482
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 4.15702
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 4.11497
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.11497
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.08536
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.85236
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.76654
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.67887
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.67775
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.64172
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.62885
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.52432
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.25796
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, SRC, XDH 2.97376
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.91975
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.89732
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 2.89732
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.87137
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.86871
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.86871
[MF] GO:0003845 None HSD11B1, HSD11B2 2.86871
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.83235
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.8209
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.78386
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, HSD11B2, HSD17B1, PPARA 2.7682
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.7682
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.47714
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.34944
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.32806
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.2917
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.25475
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, PPARA 2.24258
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, PPARA 2.2016
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.16198
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.09669
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.08777
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.06476


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.8
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.7438
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.8
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.0629
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.6887
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.5728
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 4.0581
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.2433
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 4.1223
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2433
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.9389
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.4141
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.9598
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.8864
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.2503
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.4024
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.2962
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 2.032
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2962
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.3591
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1749
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.9776
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4, MMP1, PPARA 2.3067
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7513
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7962
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.5119
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2247
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4541
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.3796
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4522
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4204
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.366
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.436
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.2066
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1108
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.365
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1981
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1568
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.2247
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2842
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0919
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.3639
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.1258
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0979
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1899
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0756
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0756
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0756
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.9872
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8811
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.0442
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.9678
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7962
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9772
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8649
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7635
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8401
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.7667
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.7635
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8419
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7867
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0584
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.6375
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3181
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3706
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4125
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4368
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4261
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4859
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4123
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.473
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4694
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4859
Platelet activation_Homo sapiens_hsa04611 SRC 0.5116
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4568
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4843
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4972
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5122
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5369
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4972
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5116
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5116
Axon guidance_Homo sapiens_hsa04360 MET 0.5065
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5805
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.534
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5653
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5686
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5653
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5725
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5805
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5805
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5725
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5805
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5805
Gap junction_Homo sapiens_hsa04540 SRC 0.5805
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5725
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5805
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.622
Peroxisome_Homo sapiens_hsa04146 XDH 0.5854
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6212
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.6002
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6377
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.6377
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6396
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6289
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6377
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6377
Bile secretion_Homo sapiens_hsa04976 CA2 0.6282
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6377
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6299
Shigellosis_Homo sapiens_hsa05131 SRC 0.6377
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6619
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6377
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6942
Malaria_Homo sapiens_hsa05144 MET 0.7051
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7106
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7077
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7106
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.7106
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7635
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8401
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8551
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8551
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8739
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8649
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.0002
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2331
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0756
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3202


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)