TCM Prescription: Ming Mu Yang Gan Pills



Prescription Description
Prescription IDTCMF4529
Pinyin NameMing Mu Yang Gan Wan
Chinese Name明目羊肝丸
English NameMing Mu Yang Gan Pills
Function Description青盲
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2419 NA 羊肝 TCMH2419
TCMH1698 Semen celosiae 青葙子 TCMH1698
TCMH2117 Lepidium apetalum 葶苈子 TCMH2117 ITSAB3973-14
TCMH448 Fructus kochiae 地肤子 TCMH448
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH263 Fructus leonuri 茺蔚子 TCMH263
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH1754 Nux prinsepiae 蕤仁 TCMH1754
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, EPHX2, ERBB2, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, MIF, PPARA, TRPV1 13.9593
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, EPHX2, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, KDR, MET, MIF, PPARA, PRKCA, SRC, TNKS, TNKS2, TRPV1, XDH 10.0023
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, MIF 9.90099
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, MIF 9.68349
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.50335
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2 9.31016
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, EPHX2, ERBB2, FABP3, FABP4, FUT7, MET, MIF, PPARA 8.78232
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EPHX2, FABP3, FUT7, MIF, PIM1, PPARA, TYR, XDH 8.78232
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, MIF 8.00036
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, HCAR2, KDR, MET, MIF, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 7.62239
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, HCAR2, KDR, MET, MIF, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 7.60745
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, FABP3, MIF, PPARA 7.45248
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2 7.21055
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, EPHX2, ERBB2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 7.16538
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2 7.15415
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2 7.12581
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPRS, RORC, SRC, TNKS2, TYR 6.98373
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.85006
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, EPHX2, ERBB2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, PRKCA, RORC, SRC, TRPV1, TYR 6.79444
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PPARA, PRKCA, RORC, SRC, TRPV1, TYR 6.78174
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, EPHX2, ERBB2, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 6.60514
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 6.35772
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.33523
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ERBB2, FLT3, MET, MIF, PIM1, SRC, TYR 6.33228
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, EGFR, HCAR2, KDR, MIF, SRC, TNKS, TNKS2, TRPV1 6.26656
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 6.14068
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TRPV1, TYR 6.08454
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.95353
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, HCAR2, HSD11B1, HSD17B1, HSD17B2, PRKCA 5.94678
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.86047
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC 5.80073
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 5.7718
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP3, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, PIM1, PRKCA, SRC, XDH 5.75904
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, TRPV1, XDH 5.74297
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PPARA, PRKCA, PTPN1, SRC, TRPV1 5.71179
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, ERBB2, FLT3, KDR, MET, MIF, PRKCA, PTPN1, SRC, XDH 5.68
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, KDR, MET, MIF, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 5.66513
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, EPHX2, ERBB2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, NR3C1, PIM1, PPARA, PRKCA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TYR, XDH 5.65905
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIM1, PRKCA, PTPN1, SRC, TRPV1, XDH 5.65025
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MET, MIF, MMP9, PIM1, PRKCA, PTPN1, SRC 5.6304
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AXL, BCL2, CACNA1C, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, EGFR, EPHX2, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TRPV1, TYR 5.52757
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, BCL2, CHRM1, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, MMP9, PRKCA, SRC 5.49275
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, MMP9, PRKCA, SRC 5.4787
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, FABP3, MIF, PPARA 5.41898
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, FLT3, HSD11B1, HSD17B2, KDR, PPARA, PTPRS, SRC, TYR 5.25192
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.24014
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, MMP9, PRKCA, SRC 5.18656
[BP] GO:0033993 response to lipid AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR 5.10867
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, IGF1R, KDR, MIF, MMP9, PIM1, PRKCA, PTPN1, SRC, TRPV1, XDH 5.08198
[BP] GO:0014070 response to organic cyclic compound APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC, TRPV1, TYR 5.08198
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 5.05536
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MIF, MMP9, PIM1, PRKCA, PTPN1, SRC 4.99454
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, SRC, TRPV1 4.96126
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CHRM1, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, PIM1, PRKCA 4.80556
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, KDR, MET, MIF, MMP9, PRKCA, SRC 4.76667
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, EPHX2 4.70267
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.69405
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PRKCA, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 4.67881
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, PTPRS, RORC, SRC, TYR 4.57204
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PRKCA, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 4.56617
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.56393
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 4.54188
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, EPHX2, ERBB2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 4.53903
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC, TNKS 4.53105
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MIF, MMP9, PRKCA, PTPN1, SRC, XDH 4.47192
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APP, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, RORC, SRC, TRPV1 4.46564
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, ALOX12, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, EPHX2, FABP3, FABP4, FLT3, MET, SRC, TRPV1 4.46537
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, EPHX2, RORC 4.45213
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC 4.4499
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.41922
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, KDR, MET, MIF, MMP2, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, XDH 4.41922
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FABP3, FLT3, KDR, MIF, MMP9, PRKCA, PTPN1, SRC, XDH 4.38204
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FABP3, FLT3, KDR, MIF, MMP9, PRKCA, PTPN1, SRC, XDH 4.38204
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, ERBB2, FLT3, KDR, MIF, PRKCA, PTPN1, SRC, XDH 4.37028
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR 4.37028
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CHRM1, CYP19A1, EGFR, ERBB2, HCAR2, MIF, MMP9, PPARA, PRKCA, PTPN1, SRC, TRPV1 4.37028
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, ERBB2, PPARA 4.34028
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 4.33962
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, FABP3, MIF, PIM1, PPARA, TYR 4.31321
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.2936
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.23357
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CDC25B, CHRM5, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PPARA, PRKCA, PTPN1, SRC, XDH 4.22527
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.18857
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CDC25B, CHRM5, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PPARA, PRKCA, PTPN1, SRC, XDH 4.17507
[BP] GO:0009725 response to hormone AKR1B1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, NR3C1, PPARA, SRC, TRPV1 4.08009
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MIF 4.05718
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, ERBB2, KDR, MIF, PRKCA, PTPN1, SRC 4.03434
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, ALOX12, APP, AXL, BCL2, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, ERBB2, HCAR2, KDR, MET, MIF, MMP9, PIM1, PRKCA, PTPRS, SRC, TNKS2, TRPV1, XDH 4.02798
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, EPHX2, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PTPN1, PTPRS, SRC, TNKS, XDH 4.02798
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, EPHX2, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 4.00847
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, EPHX2, ERBB2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 3.98708
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC, TRPV1 3.91796
[BP] GO:0032845 None ADORA1, BCL2, MIF, SRC, TNKS, TNKS2, TRPV1 3.8833
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, APP, AXL, BCL2, CA1, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1 3.85164
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, KDR, MIF, MMP9, PRKCA, PTPN1, SRC, XDH 3.84837
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.84382
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, FABP3, MIF, PIM1, PPARA, TYR 3.84382
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, ERBB2, HCAR2, MIF, SRC, TRPV1 3.76494
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, EPHX2, ERBB2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MIF, MMP2, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SRC, TRPV1, TYR 3.76494
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2, FABP3, MIF, PIM1, PPARA, TYR 3.75748
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, EPHX2, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PTPN1, PTPRS, SRC, TNKS, XDH 3.73729
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, ERBB2, FLT3, IGF1R, KDR, MIF, PRKCA, PTPN1, SRC, XDH 3.7332
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.71634
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.71634
[BP] GO:0003018 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, EPHX2, SRC 3.71209
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, KDR, MIF, MMP9, PRKCA, PTPN1, SRC, XDH 3.65109
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.65109
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.64805
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.64805
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, NR3C1, PTPN1, RORC, SRC, TRPV1 3.6472
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, NR3C1, SRC, TRPV1 3.64535
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 3.59032
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, CACNA1C, CHRM1, CHRM2, CHRM3, EGFR, HCAR2, PRKCA, TRPV1 3.56629
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC, TNKS 3.55778
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.51469
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, EGFR, EPHX2 3.50293
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.49689
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, EPHX2, ERBB2, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 3.47942
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.4786
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FABP3, FABP4, HCAR2, IGF1R, KDR, MET, MIF, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 3.43399
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.43399
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MIF, MMP2, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2, TRPV1 3.4327
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.39312
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MIF, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 3.38143
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PPARA, PRKCA, PTPN1, SRC, XDH 3.37739
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, EPHX2, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 3.37739
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, EGFR, IGF1R, KDR, MET, MMP9, PRKCA, SRC 3.36947
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC 3.32044
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, ALOX12, MET, TRPV1 3.31944
[BP] GO:0071407 cellular response to organic cyclic compound APP, CYP1A1, CYP1B1, EGFR, FLT3, NR3C1, RORC, SRC, TRPV1 3.31455
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, ALOX12, APP, AXL, BCL2, CA2, CHRM3, CYP1B1, EGFR, HCAR2, KDR, MET, MIF, MMP9, PIM1, PRKCA, SRC, TRPV1 3.28892
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PRKCA, PTPN1, SRC, XDH 3.28074
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, EGFR, IGF1R, KDR, MET, MMP9, PRKCA, SRC 3.26887
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, EPHX2, FABP3, FABP4, MET, TRPV1 3.26787
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, CHRM1, EGFR, ERBB2, HCAR2, MIF, PRKCA, PTPN1, SRC 3.26643
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.24255
[BP] GO:0097746 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, EPHX2 3.23255
[BP] GO:0035296 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, EPHX2 3.23255
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.23255
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.23255
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.21654
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.20205
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, EGFR, IGF1R, KDR, MET, MMP9, PRKCA, SRC 3.19284
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, MIF, PRKCA, SRC 3.16689
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, ALOX15, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 3.15509
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, NR3C1, SRC, TRPV1 3.13214
[BP] GO:1903522 None ADORA1, ADORA3, ADRB1, CACNA1C, CHRM1, CHRM2, CHRM3, EGFR 3.10973
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP2, MMP9, PPARA, PRKCA, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 3.10973
[BP] GO:0050880 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, EPHX2 3.10973
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 3.10811
[BP] GO:0035150 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, EPHX2 3.09526
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, EGFR, IGF1R, KDR, MET, MMP9, PRKCA, SRC 3.08466
[BP] GO:0003013 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, EPHX2, SRC 3.08254
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 3.08254
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, EPHX2, ERBB2, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TRPV1, TUBB3, TYR, XDH 3.07657
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, MIF 3.04233
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, MMP2, PPARA, SRC, TRPV1, TYR 3.03345
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.02502
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ALOX12, APP, CYP19A1, EGFR, FABP4, IGF1R, MET, MIF, MMP2, PPARA, PRKCA, PTPN1, PTPRS, SRC, XDH 3.02084
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FABP3, FABP4, IGF1R, KDR, MET, MIF, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 3.01425
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PRKCA, SRC, TNKS 2.97745
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, MIF 2.97551
[BP] GO:0038128 None EGFR, ERBB2, PRKCA, SRC 2.96956
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, TNKS 2.96956
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, EGFR, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 2.93963
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.93066
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.91966
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.91966
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.91966
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.87712
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, TNKS, TNKS2 2.85003
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, KDR, MIF, MMP9, PRKCA, PTPN1, SRC, XDH 2.80737
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, MIF, PTPN1, SRC 2.79443
[BP] GO:0007188 None ADORA1, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5 2.75876
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTPN1, SRC 2.69728
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.67446
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.67316
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.67316
[BP] GO:0030258 lipid modification ALOX12, CYP1A1, CYP3A4, EGFR, EPHX2, ERBB2, MET 2.66615
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, ERBB2, KDR, NR3C1, SRC, TRPV1 2.64704
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, IGF1R, MIF, PTPN1, SRC 2.63656
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.62544
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, MIF, MMP9, PRKCA, RORC, SRC, TRPV1 2.62057
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 2.61664
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.61664
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.60646
[BP] GO:0070201 None ACHE, APP, BCL2, CACNA1C, CHRM1, EGFR, ERBB2, HCAR2, MIF, PRKCA, PTPN1, SRC 2.6039
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, EPHX2, ERBB2, FLT3, IGF1R, KDR, MET, MIF, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.57215
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.5507
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MIF, MMP9, PRKCA, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 2.53784
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP2, MMP9, TRPV1 2.50397
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.50397
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.50397
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.50397
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.48459
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, IGF1R, MET, MIF, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, TNKS, TRPV1, XDH 2.48356
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.48356
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, MIF, PTPN1, SRC 2.48356
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.48356
[BP] GO:0007187 None ADORA1, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5 2.43162
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, EPHX2, ERBB2, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.43162
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CYP19A1, EGFR, ERBB2, IGF1R, MET, MIF, MMP9, PPARA, PTPN1, PTPRS, SRC, XDH 2.42718
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, EGFR, MIF, PRKCA, SRC 2.41969
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, MIF, PTPN1, SRC, TNKS 2.41558
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CACNA1C, CHRM1, MIF, MMP9 2.38711
[BP] GO:0001503 ossification ALOX15, BCL2, EGFR, MMP2, MMP9 2.38582
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, EPHX2, ERBB2, MIF, MMP2, MMP9, PPARA, PTPN1, SRC, TRPV1 2.3813
[BP] GO:0032880 regulation of protein localization ACHE, APP, BCL2, CACNA1C, CHRM1, CSNK2A1, EGFR, ERBB2, HCAR2, MIF, PRKCA, PTPN1, SRC 2.36542
[BP] GO:0070848 response to growth factor APP, EGFR, ERBB2, KDR, NR3C1, SRC, TRPV1 2.35171
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MIF, SRC, TRPV1 2.34175
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.32863
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.31261
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, PPARA, RORC, SRC 2.31261
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 2.28874
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.27981
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.26401
[BP] GO:0070213 None TNKS, TNKS2 2.25547
[BP] GO:0097176 epoxide metabolic process ALOX12, EPHX2 2.25547
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25547
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.23842
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, CHRM1, EGFR, ERBB2, HCAR2, MIF, SRC 2.23322
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, CHRM1, CHRM3, MET, PRKCA, XDH 2.22795
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, SRC 2.22795
[BP] GO:0061900 None APP, EGFR, TRPV1 2.22379
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.22379
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.22097
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, BCL2, CYP1A1, CYP1B1, EPHX2, KDR, SRC 2.21913
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, MET 2.20709
[BP] GO:0051223 None ACHE, APP, CACNA1C, CHRM1, EGFR, ERBB2, HCAR2, MIF, PRKCA, PTPN1, SRC 2.20542
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, FABP4, FLT3, IGF1R, MIF, MMP9, PRKCA, PTPN1, SRC, TNKS, XDH 2.20341
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, EGFR, FABP4, KDR, MET, MIF, PPARA, PRKCA, PTPRS 2.20341
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, FLT3, MET, MIF, MMP9, PTPN1, SRC, TNKS, XDH 2.20051
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, APP, BCL2, TNKS2 2.18273
[BP] GO:0040008 regulation of growth ADRB1, ALOX12, APP, BCL2, CSNK2A1, EGFR, ERBB2, PIM1, PTPRS, TNKS2 2.18273
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, MIF, PTPN1, SRC 2.1812
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, MET, SRC, XDH 2.15271
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.14039
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.14039
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, SRC, TNKS, TNKS2 2.13588
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PRKCA, PTPN1, SRC, XDH 2.13548
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, EPHX2, FABP3, TRPV1 2.10761
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.10009
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, EGFR, FABP4, HCAR2, IGF1R, KDR, MET, MIF, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.0988
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.09354
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.08838
[BP] GO:0048545 response to steroid hormone BCL2, CA2, EGFR, FLT3, NR3C1, SRC 2.08838
[BP] GO:0046541 None CHRM1, CHRM3 2.08838
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.08838
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.08838
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, KDR, MIF, MMP9, PRKCA, PTPN1, SRC, XDH 2.07433
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, MIF 2.06687
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 2.06066
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, EGFR, ERBB2, FLT3, IGF1R, MMP2, NR3C1, SRC, TRPV1 2.05781
[BP] GO:0071383 None EGFR, FLT3, NR3C1, SRC 2.05394
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, ERBB2, FLT3, MIF, PTPN1, SRC, TNKS 2.05208
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.05106
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, MIF 2.03495
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.01932
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.01932
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, MIF 2.01835
[BP] GO:0090257 None ADORA1, CACNA1C, CHRM1, CHRM2, CHRM3, PRKCA 2.01719
[BP] GO:0042060 None ALOX15, EGFR, ERBB2, PPARA 2.00167
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX12, ALOX15, ALOX5, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ERBB2, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PRKCA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TRPV1, TYR 4.4555
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX12, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PRKCA, PTPN1, PTPRS, SRC, TRPV1 3.68115
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, ERBB2 3.28892
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, EPHX2, ERBB2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, KDR, MIF, MMP2, MMP9, NR3C1, PIM1, PRKCA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 3.28351
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, MET, SRC, TRPV1 3.12964
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRB1, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PTPRS, SRC, TRPV1 3.10973
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX15, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ERBB2, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MET, PTPN1, PTPRS, SRC, TRPV1, TYR 2.79785
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, PTPRS, SRC, TRPV1 2.58543
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR 2.50397
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, IGF1R, KDR, MET, PTPRS, TRPV1 2.48356
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APP, CA4, EGFR, ERBB2, PRKCA, SRC, TNKS2, TYR 2.20974
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, IGF1R, KDR, MET, PTPRS, TRPV1 2.18273
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FLT3, HSD11B1, HSD17B2, PTPN1 2.04725
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, TNKS, TYR, XDH 14.0166
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, EPHX2, ERBB2, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PRKCA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 12.9383
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.90099
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, EPHX2, ERBB2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TRPV1, TUBB3, TYR, XDH 9.86332
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.29273
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.87952
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 7.30224
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.89484
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, PRKCA, SRC, TRPV1 6.62765
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.33523
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.26847
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 6.08454
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.95353
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EPHX2, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, TNKS, TNKS2, TRPV1, TYR, XDH 5.71179
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.50625
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.39457
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.38372
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.25586
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.05209
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EPHX2, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, TNKS, TNKS2, TRPV1, TYR, XDH 4.91096
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 4.70031
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP2, MMP9, NR3C1, PPARA, PRKCA, PTPN1, RORC, TNKS 4.53903
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.52353
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 4.41991
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.31321
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.09027
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 4.02798
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, NR3C1 4.00847
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 3.75005
[MF] GO:0008227 None ADRB1, CHRM1, CHRM2, CHRM3, CHRM5 3.59032
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 3.59032
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC 3.4327
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.33875
[MF] GO:0016803 ether hydrolase activity ALOX12, ALOX15, EPHX2 3.33875
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.33875
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.32414
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.31358
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 3.30589
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 3.25375
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET, TRPV1 3.20205
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET, TRPV1 3.20205
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, SRC, XDH 3.10973
[MF] GO:0016801 None ALOX12, ALOX15, EPHX2 3.02502
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.00776
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.91966
[MF] GO:0008389 None CYP2A13, CYP2A6 2.91966
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC 2.78891
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, MET, PPARA, PTPN1 2.6472
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.50397
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.50397
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.50397
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, SRC 2.47059
[MF] GO:0042578 None ADORA1, CDC25B, CHRM1, CHRM3, CHRM5, EPHX2, PTPN1, PTPRS 2.45468
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, MET, PTPN1 2.3239
[MF] GO:0016788 None ACHE, ADORA1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, EPHX2, PTPN1, PTPRS 2.32003
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.25547
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.25547
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.14039
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.10009
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.10009
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.10009
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.08838
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 2.08838
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, EGFR, EPHX2, ERBB2, FLT3, IGF1R, KDR, MET, MIF, MMP9, TRPV1, TYR, XDH 2.05781
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, PIM1, PRKCA, PTPRS, SRC, TRPV1, TUBB3, XDH 2.05394
[MF] GO:0019899 enzyme binding ADRB1, APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, EGFR, ERBB2, MET, MIF, NR3C1, PPARA, PRKCA, PTPN1, SRC, TNKS2 2.04909
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.03495
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.00167


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.942
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.8111
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.9678
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.1588
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2, PRKCA, CACNA1C 6.9876
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.9678
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, ERBB2, PRKCA, ADRB1, CACNA1C, EGFR 6.76
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 6.945
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, PRKCA, MMP9, MET, EGFR, IGF1R 6.3523
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.945
Metabolic pathways_Homo sapiens_hsa01100 CBR1, EPHX2, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 5.8595
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, ERBB2, BCL2, PIM1, CYP1B1, PRKCA, MMP9, MET, EGFR, CDC25B 6.0577
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, ERBB2, BCL2, PRKCA, MMP9, MET, EGFR, IGF1R 5.0588
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, ADORA3, CHRM5, ADORA1, ADRB1, TRPV1, NR3C1 5.3597
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, PRKCA, MET, EGFR, IGF1R 5.3597
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, PRKCA, ALOX12, CACNA1C 4.7095
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, ADRB1, CACNA1C, PPARA 4.3776
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, EPHX2, ALOX15, ALOX12 4.7095
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, BCL2, PRKCA, MET, EGFR, IGF1R 3.8435
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA, CACNA1C, EGFR 3.9618
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, PRKCA, ADRB1, EGFR 4.0117
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, BCL2, PRKCA, EGFR, IGF1R 3.7402
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, PRKCA, MET, EGFR, IGF1R 3.305
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR 3.2969
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.305
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 2.9104
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.3317
Prostate cancer_Homo sapiens_hsa05215 ERBB2, BCL2, EGFR, IGF1R 2.9122
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, PRKCA, EGFR 2.9359
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCA, ALOX12, TRPV1 2.7924
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, PRKCA 2.7673
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR 2.7881
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2969
Ras signaling pathway_Homo sapiens_hsa04014 KDR, PRKCA, MET, EGFR, IGF1R 2.3927
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1, PRKCA 2.5081
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, PRKCA, MMP9 2.2656
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, PRKCA, ADRB1, CACNA1C 2.2628
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PRKCA, CACNA1C, EGFR 2.2031
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 2.1241
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, PRKCA, EGFR 2.4415
Glioma_Homo sapiens_hsa05214 PRKCA, EGFR, IGF1R 2.2949
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PRKCA 2.3546
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.4415
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0314
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.3043
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2, PRKCA 2.2031
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2628
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.24
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCA, CACNA1C, EGFR, CDC25B 1.5685
Insulin secretion_Homo sapiens_hsa04911 CHRM3, PRKCA, CACNA1C 2.0584
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5253
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7924
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, CYP3A4 2.2579
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 2.24
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA, CACNA1C 2.0314
Salivary secretion_Homo sapiens_hsa04970 CHRM3, PRKCA, ADRB1 2.0251
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2, PRKCA 1.9401
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.5473
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, PRKCA, MMP9 1.727
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.6586
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.1534
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0829
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0205
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 1.0746
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2973
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PRKCA 0.8642
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCA, EGFR 1.0746
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA, CACNA1C 0.9957
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3233
FoxO signaling pathway_Homo sapiens_hsa04068 EGFR, IGF1R 0.9069
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6716
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PRKCA, EGFR 0.8617
Circadian entrainment_Homo sapiens_hsa04713 PRKCA, CACNA1C 1.102
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3362
Morphine addiction_Homo sapiens_hsa05032 ADORA1, PRKCA 1.1252
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3436
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, PRKCA 0.9788
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9069
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCA, CACNA1C 0.9208
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8147
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3228
Influenza A_Homo sapiens_hsa05164 PRKCA 0.3362
Taste transduction_Homo sapiens_hsa04742 CHRM3, CACNA1C 1.1873
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.1286
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA, CACNA1C 1.1956
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7416
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCA, CACNA1C 1.0746
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.7757
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9788
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3711
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1135
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA, CACNA1C 0.971
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3748
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3945
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3945
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3925
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3985
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCA 0.3985
Platelet activation_Homo sapiens_hsa04611 SRC 0.4215
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4215
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4215
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2201
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4215
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4215
Axon guidance_Homo sapiens_hsa04360 MET 0.4161
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4486
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.1873
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4764
Amoebiasis_Homo sapiens_hsa05146 PRKCA 0.4768
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCA 0.4907
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCA 0.481
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4892
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4899
Long-term potentiation_Homo sapiens_hsa04720 PRKCA, CACNA1C 1.3433
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4995
Pancreatic cancer_Homo sapiens_hsa05212 ERBB2, EGFR 1.3433
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5013
Amphetamine addiction_Homo sapiens_hsa05031 PRKCA, CACNA1C 1.337
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5003
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5064
Long-term depression_Homo sapiens_hsa04730 PRKCA, IGF1R 1.4093
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5164
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5366
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4391
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5602
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.5717
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.564
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.5022
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5532
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5621
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4169
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5797
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.582
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCA 0.5984
Shigellosis_Homo sapiens_hsa05131 SRC 0.582
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3, PRKCA 1.4623
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.582
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5894
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.659
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.659
Malaria_Homo sapiens_hsa05144 MET 0.6674
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA 0.6722
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6716
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6949
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCA 0.7397
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.7757
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9112
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.794
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8147
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8617
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7773
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8633
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8642
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8222
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0941
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8617
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3597
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.0004


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)