TCM Prescription: Yun Kang Granules



Prescription Description
Prescription IDTCMF452
Pinyin NameYun Kang Ke Li 
Chinese Name孕康颗粒
English NameYun Kang Granules
Function Description先兆流产和习惯性流产
IndicationsThreatened abortion, Habitual aborter
Disease ICD-11 Category JA40.0 [Threatened abortion, 先兆流产 ];
GA33 [Recurrent pregnancy loss, 反复性妊娠丢失 ];
Human Tissues Associated with IndicationUterus
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH2334 Dipsacus japonicus 续断 TCMH2334 ITSAC1509-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH693 Cudrania cochinchinensis 狗脊 TCMH693
TCMH1791 Loranthus parasiticus 桑寄生 TCMH1791
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH541 Colla corii asini 阿胶 TCMH541
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH2674 Radix boehmeriae 苎麻根 TCMH2674
TCMH12 Artemisia argyi 艾叶 TCMH12 ITSAE2504-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH2488 Alpinia oxyphylla 益智 TCMH2488 ITSAJ4276-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, PPARA, PPARG, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.6352
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6422
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, PPARG, PTGS2, RORC, SMAD3, SRC, TEK, TYR 10.0772
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, HSP90AB1, IGF1R, INSR, MMP2, MMP9, PPARA, PPARG, PTGS2, RORC, SRC, TEK, TYR 9.9394
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.89634
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, PPARG, PTGS1, PTGS2 9.86504
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PPARG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.23268
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GLO1, HMGCR, HSPA1A, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR, XDH 9.169
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PPARG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.10024
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, PPARG, PTGS2, RORC, SMAD3, SRC, TEK, TYR 8.96786
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.95706
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.93211
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 8.475
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 8.26594
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 8.00942
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 7.70638
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CHRM1, CSNK2A1, CXCL8, CYP1B1, EGFR, ESR1, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARG, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 7.70638
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.70638
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.70638
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 7.70638
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.43189
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 7.31211
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARG, PTGS2, RORC, SMAD3, SRC 7.31211
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.26844
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CXCL8, CYP1A2, EGFR, ESR1, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PPARG, PTGS2, SMAD3, SRC, TEK 7.26844
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 7.21404
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.1871
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, CA2, CA7, CHRM1, CSNK2A1, CXCL8, CYP19A1, CYP1B1, EGFR, F10, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK 7.1871
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 7.1871
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CXCL8, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, INSR, KDR, MMP2, PPARG, PTGS2, RORC, SMAD3, SRC 7.04053
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 6.63758
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR 6.55243
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD17B1, HSD17B2, PPARG, PTGS1, PTGS2, TYR, XDH 6.54912
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, PPARG, PTGS2, RORC, SRC, TEK, TYR 6.48363
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1 6.45583
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.43642
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 6.4274
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG, PTGS1, PTGS2 6.36457
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CXCL8, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, GRM1, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.32919
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PPARG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 6.24265
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 6.1695
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.1494
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A 6.1494
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CXCL8, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARG, PTGS2, SMAD3, SRC, TEK 6.14855
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 6.11675
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, PPARA, PPARG, PTGS1, PTGS2 6.11675
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.08943
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.08943
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, PTGS2, PTPN1, SRC, TEK, XDH 6.03962
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.03291
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 6.02215
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA6, CA9, CHRM2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR 6.02215
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, PPARA, PPARG, PTPRS, SMAD3, SRC, TEK, TYR 6.0214
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CHRM1, CXCL8, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARG, PTGS2, SMAD3, SRC, TEK 5.98384
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, CXCL8, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 5.89612
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, PPARG, PTGS2, RORC, SRC, TYR 5.87689
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TYR 5.87094
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CXCL8, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARG, PTGS2, SMAD3, SRC, TEK 5.78139
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.77437
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 5.72579
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PPARG, PTGS2, SRC, TEK 5.66688
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, PPARG, PTGS2, RORC, SRC 5.66688
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, MET, PPARG, SMAD3, SRC 5.65429
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CXCL8, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PPARG, PTGS2, RORC, SRC 5.62082
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 5.60307
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, GRM1, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PPARG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.60147
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 5.56309
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PPARG, PTGS2, RORC, SRC, TEK 5.52622
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FABP4, FLT3, GPR35, GRM1, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PPARG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.47831
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.47831
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.47831
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 5.46771
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 5.41414
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CXCL8, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARG, PTGS2, SMAD3, SRC, TEK 5.30145
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.27215
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, GRM1, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, PTGS2, SMAD3, SRC, TEK, TYR 5.24107
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CXCL8, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.21922
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1 5.21101
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TYR 5.18615
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3 5.17957
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3 5.17957
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, PTPN1, SRC, TEK, TNKS 5.17957
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.14316
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 5.14211
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 5.09355
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PPARA, PPARG, PTGS1, PTGS2 5.08973
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.07032
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CHRM1, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC 5.0407
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.01168
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS 4.92626
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PTGS2, SRC, TEK, TYR 4.91169
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, PPARG, PTGS2, SRC, TEK 4.87948
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.875
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.81896
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 4.77788
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS 4.77359
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CXCL8, CYP1B1, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 4.7314
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSP90AB1, HSPA1A, MMP12, MMP2, PPARA, PPARG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK 4.72159
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.6869
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.6869
[BP] GO:0030335 positive regulation of cell migration APP, CXCL8, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.6869
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.6771
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3 4.6407
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 4.54859
[BP] GO:2000147 positive regulation of cell motility APP, CXCL8, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.52183
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 4.51452
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, XDH 4.51087
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PTGS2, SRC, TEK, TYR 4.49536
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, CXCL8, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 4.48655
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3 4.42175
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CXCL8, CYP1B1, EGFR, ESR1, GPR35, GRM1, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIM1, PPARG, PTGS2, PTPRS, SLC1A1, SMAD3, SRC, TEK, TNKS2, XDH 4.42045
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.41687
[BP] GO:0051272 positive regulation of cellular component movement APP, CXCL8, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.40944
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, HSP90AA1, HSP90AB1, INSR, PTGS2, SLC1A1, SMAD3 4.36758
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 4.35682
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 4.33521
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, CXCL8, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH 4.33082
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, CXCL8, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH 4.31402
[BP] GO:0040017 positive regulation of locomotion APP, CXCL8, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.25943
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.24599
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.24519
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC, TNKS, TNKS2 4.16326
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, EGFR, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.16326
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.16326
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.14219
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.13784
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, CXCL8, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, PPARG, PTGS2, SMAD3, SRC 4.12893
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS, TNKS2 4.12323
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 4.11828
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CHRM1, CSNK2A1, EGFR, ESR1, FLT3, HMGCR, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 4.11547
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CXCL8, CYP19A1, EGFR, ESR1, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PPARG, PTGS2, PTPRS, SMAD3, TEK 4.11547
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, PTGS2, SRC, TEK 4.10091
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.09161
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, SRC, TNKS, TNKS2 4.08787
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH 4.07738
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.06432
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.06432
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.06432
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.04128
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, CDC25B, EGFR, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MET, MMP9, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.94941
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.9344
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, HSP90AB1, PTGS1, RORC 3.91963
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.91619
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.91619
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 3.90812
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 3.90264
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 3.8957
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, XDH 3.85927
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 3.85525
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.84123
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.84123
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 3.83117
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2 3.80043
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, HSP90AB1, KDR, PPARG, PTGS2, SRC 3.7991
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, CDC25B, CSNK2A1, CXCL8, CYP1A1, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TNKS, TOP2A 3.79782
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PPARG, SMAD3 3.79349
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, CDC25B, EGFR, ESR1, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.79349
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PPARG, PTGS2, SRC, TEK 3.73716
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, INSR, PTPN1, SRC, TEK 3.72992
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, PTPRS, XDH 3.72992
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 3.70033
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, CA2, CHRM1, CYP19A1, EGFR, HCAR2, HSP90AB1, INSR, MMP12, PPARG, PTGS2, SMAD3, SRC 3.68905
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, EGFR, HCAR2, HMGCR, KDR, PTGS2, SRC, TNKS, TNKS2 3.67583
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 3.67583
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSP90AA1, HSPA1A, INSR, PIM1, SMAD3, TNKS, TOP2A 3.66689
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, PPARG, PTGS2, SRC 3.64672
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PPARG, PTGS2 3.64389
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PPARG, PTGS2, TYR 3.64298
[BP] GO:1903426 None EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3 3.64298
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, PTGS2, SLC1A1, TEK 3.62515
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.59871
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.57319
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 3.51154
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, PTPN1, SRC, TEK, TNKS 3.50147
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.49703
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.49703
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.49137
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, INSR, PTPN1, SRC 3.48599
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.47124
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.47124
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 3.45826
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PTPN1, SRC 3.42285
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GLO1, HMGCR, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 3.4162
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.40275
[BP] GO:0051098 regulation of binding APP, AURKB, HSP90AB1, MET, MMP9, PPARA, PPARG, SMAD3, SRC, TNKS 3.3964
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, PPARG, PTGS2, SRC 3.36429
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 3.36181
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, EGFR, GPR35, GRM1, HCAR2, PTGS2, SLC1A1, SMAD3 3.34271
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, PTGS2, SRC, TEK 3.33804
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 3.3301
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.30524
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, INSR, PPARG, SRC 3.2969
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.28826
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CHRM3, CXCL8, CYP1B1, EGFR, HCAR2, HMGCR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PPARG, PTGS2, SLC1A1, SMAD3, SRC, TEK 3.28826
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.27703
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CXCL8, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, PPARG, SRC 3.26379
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 3.2616
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 3.25574
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, SMAD3, SRC, TEK, TNKS, TNKS2 3.2498
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSP90AB1, KDR, PTGS2, SRC 3.24812
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, CDC25B, EGFR, ESR1, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.23876
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.23176
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, PPARA, PPARG, RORC, SRC, TOP2A 3.23176
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.22923
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 3.22007
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, SLC1A1 3.21845
[BP] GO:0009968 negative regulation of signal transduction CXCL8, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH 3.20068
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PPARG, PTGS2, SMAD3, SRC, TEK 3.15981
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSP90AB1, INSR, SRC 3.14826
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.1389
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 3.13809
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, CXCL8, EGFR, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MMP12, MMP9, PPARA, PPARG, SLC1A1, SRC, TNKS, TNKS2, XDH 3.13329
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.12337
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD17B1, HSD17B2, PTGS1, PTGS2 3.11791
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 3.09937
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, PTGS2, TNKS, TNKS2 3.08446
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.05142
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP2A 3.01467
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.00932
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, PTGS2 3.00423
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, SRC, TNKS, TNKS2 3.00423
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PPARG, PTGS2, SMAD3, TEK 3.00423
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, CXCL8, EGFR, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MMP12, MMP9, PPARA, PPARG, SLC1A1, SRC, TNKS, XDH 2.96609
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, PPARG, SMAD3, TEK 2.94456
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 2.93991
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.9357
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.93555
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, PPARG, SMAD3, TEK 2.92563
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 2.90596
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 2.89617
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, PPARG, RORC, SRC 2.89277
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, HMGCR, HSP90AA1, KDR, SRC 2.89224
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.89063
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, PTGS2, SRC 2.86139
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, CA2, CXCL8, CYP19A1, DUSP3, ESR1, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, MMP12, MMP2, PPARG, PTPN1, PTPRS, SMAD3, SRC 2.84555
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, FABP4, GRM3, GRM8, HMGCR, HSP90AB1, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.84535
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 2.84083
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 2.83777
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 2.8288
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC, TEK 2.82826
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, CXCL8, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MMP12, MMP9, PPARA, PPARG, SLC1A1, SRC, TNKS, XDH 2.82826
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.82826
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, PTGS2, SRC 2.82826
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP12, PPARA, PPARG, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.82826
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, HSP90AB1, IGF1R, INSR, PTPN1, SRC 2.82826
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, HSP90AA1, HSP90AB1, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 2.82826
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, EGFR, HCAR2, HMGCR, HSP90AB1, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.80779
[BP] GO:0051973 positive regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, TNKS 2.80516
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, ESR1, ESR2, GRIK5, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.80371
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.80236
[BP] GO:0097746 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, PTGS2 2.78005
[BP] GO:0035296 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, PTGS2 2.78005
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.76428
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR 2.76428
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.76428
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.74844
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD17B1, HSD17B2 2.74733
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 2.7375
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.7375
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.7375
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 2.7375
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.71838
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.70044
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, HSP90AB1, PTGS2, SMAD3, SRC 2.68492
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, PPARG, RORC, SRC 2.68492
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, HMGCR, PPARG, PTGS2, TYR 2.67769
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.67051
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.66448
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.66278
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 2.65878
[BP] GO:0050880 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, PTGS2 2.65514
[BP] GO:0035150 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, PTGS2 2.63795
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, HMGCR, KDR, SRC, TEK 2.62965
[BP] GO:0048608 reproductive structure development AXL, CYP19A1, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, SRC 2.62935
[BP] GO:0050890 None ADORA1, APP, CHRM1, EGFR, GRM5, HMGCR, INSR, PTGS2 2.61034
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5 2.60616
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PPARG, PTGS2, SRC, TEK 2.54827
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, HSD17B2, HSP90AB1, INSR, MMP2, MMP9, PPARG, PTGS2, SRC, TOP2A 2.54376
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.54322
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, PTPN1, SRC, TEK 2.54234
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, HMGCR, PPARA, PPARG, PTPRS, SMAD3, TEK 2.5421
[BP] GO:0043393 regulation of protein binding APP, AURKB, HSP90AB1, MET, MMP9, PPARA, SRC 2.53567
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH 2.52348
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.50717
[BP] GO:0051131 None HSP90AA1, HSP90AB1, HSPA1A 2.50717
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.50717
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, MET, MMP12, PPARA, PPARG, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.48956
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, EGFR, PTGS2, SLC1A1 2.48658
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR 2.47252
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.45272
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PPARG, PTGS2, TEK, TYR 2.44265
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.43484
[BP] GO:0099566 None GRM1, GRM5 2.4342
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4342
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.42949
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP12, PPARA, PPARG, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.42949
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PPARG, PTGS2, SRC, TEK 2.42949
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.42949
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.41907
[BP] GO:0008217 None ADORA1, PPARA, PPARG, PTGS1, PTGS2, SMAD3 2.40725
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, CSNK2A1, DUSP3, ESR1, ESR2, FABP4, GRM3, GRM8, HMGCR, HSP90AB1, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.38009
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, CHRM1, EGFR, HCAR2, HSP90AB1, MMP12, PTGS2, SMAD3, SRC 2.34755
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.34169
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 2.32891
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.29369
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.29285
[BP] GO:0042307 positive regulation of protein import into nucleus APP, EGFR, HSP90AB1, PTGS2, SMAD3 2.28629
[BP] GO:0042752 None ADORA1, PPARA, PPARG, RORC, TOP2A 2.28629
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, PTPN1, SRC 2.2525
[BP] GO:0042391 None ADORA1, APP, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.2525
[BP] GO:1904591 positive regulation of protein import APP, EGFR, HSP90AB1, PTGS2, SMAD3 2.24793
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.23283
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.23283
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.23283
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.23283
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.23283
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.20692
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.20692
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH 2.205
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, GRIK5, HCAR2, HMGCR, MMP9, PPARG, PTGS2, SMAD3, SRC, TOP2A, XDH 2.1968
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.18907
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CSNK2A1, CYP1A1, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, TNKS 2.18087
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.18002
[BP] GO:0070213 None TNKS, TNKS2 2.18002
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.18002
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.18002
[BP] GO:0001959 None AXL, HSP90AB1, HSPA1A, MMP12, PPARG, PTPN1 2.17393
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, PPARA, PPARG, RORC, SRC 2.17393
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, GRIK5, HCAR2, HMGCR, MMP9, PPARG, PTGS2, SMAD3, SRC, TOP2A, XDH 2.17393
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.17221
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, HMGCR, TYR 2.17005
[BP] GO:0001775 cell activation ALOX5, APP, AXL, CXCL8, EGFR, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, RORC, SMAD3, SRC 2.15851
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.15851
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.15851
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, PTPN1, SRC 2.15851
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, CHRM1, EGFR, HCAR2, HSP90AB1, MMP12, PTGS2, SMAD3, SRC 2.15263
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.15245
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.1467
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.1467
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.13853
[BP] GO:0071363 cellular response to growth factor stimulus APP, CXCL8, EGFR, INSR, KDR, SMAD3, SRC 2.13707
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, CBR1, CDC25B, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MET, MMP2, MMP9, PPARG, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TOP2A 2.13664
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.13334
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.12867
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.10207
[BP] GO:0045088 regulation of innate immune response ESR1, HSP90AB1, HSPA1A, MMP12, MMP2, PPARG, PTPN1, PTPRS, SRC 2.10149
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.09609
[BP] GO:0060759 None AXL, HSP90AB1, HSPA1A, MMP12, PPARG, PTPN1 2.08796
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A 2.07856
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.07152
[BP] GO:0019229 None CHRM1, CHRM3, EGFR, PTGS2 2.07152
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, CYP1A1, EGFR, HMGCR, PPARG, PTGS2, SRC, TYR 2.05661
[BP] GO:0051894 None KDR, SMAD3, TEK 2.05661
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.05661
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.05661
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PPARG, SRC 2.05661
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, FABP4, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.05661
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.05123
[BP] GO:0003008 None ADORA1, AKR1B1, APP, CHRM1, CHRM3, CHRM5, CYP1B1, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, PTGS2, SRC, TEK, TYR 2.01417
[BP] GO:0050927 None CXCL8, KDR, SMAD3 2.00961
[BP] GO:0046541 None CHRM1, CHRM3 2.00712
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.00712
[BP] GO:0010891 None PPARA, PPARG 2.00712
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, INSR, MET, PTGS2, SLC1A1, SRC, TEK 8.73609
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DUSP3, EGFR, F10, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PTGS2, PTPRS, SLC1A1, SRC, TEK 6.48658
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, ESR1, F10, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK 5.45178
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, F10, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTPRS, SLC1A1, TEK 5.1335
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, F10, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR 5.00103
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 4.80331
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SRC 4.70998
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PTGS1, PTGS2, PTPN1, PTPRS, SLC1A1, SRC, TEK, TYR 4.37196
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTPRS, SLC1A1, TEK 4.31402
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC, TUBB3 4.06432
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, HSP90AB1, TEK 3.60623
[CC] GO:0043235 receptor complex APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, HSP90AB1, IGF1R, INSR, SMAD3 3.60434
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 3.2616
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, INSR, PTGS1, SRC 3.24584
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, INSR, PTGS1, SRC 3.24584
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.09315
[CC] GO:0097458 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, PTGS1, PTGS2, PTPRS, SRC, TUBB3 2.84247
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2 2.72816
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC, TEK, TUBB3 2.72281
[CC] GO:0014069 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.61935
[CC] GO:0099572 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.61935
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC, TEK, TUBB3 2.44647
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, FLT3, GRIA2, HMGCR, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 2.31743
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MMP2, MMP9, PIM1, PPARG, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.18087
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, GRIK5 2.18002
[CC] GO:0030054 cell junction ACHE, AKR1B1, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2, GRIA4, GRIK5, HCAR2, HSPA1A, KDR, PTPRS, TEK 2.17071
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, PPARG, SRC, TNKS2, TYR 2.01417
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.7336
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 15.3439
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 12.9823
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 12.336
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.9394
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.86504
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, PPARG, RORC, TEK 7.94081
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PPARG, PTPN1, RORC, SMAD3, TNKS 7.88307
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.64858
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.42017
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD17B1, HSD17B2, PTGS1, PTGS2, TYR, XDH 7.1871
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, PPARG, RORC, TEK 6.97755
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH 6.92666
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, PPARG, RORC, SMAD3, TEK 6.72163
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, PPARG, RORC, TEK 6.69127
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.68558
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, SRC, TEK, TOP2A 6.66661
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK 6.19631
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK 6.19631
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.18832
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 6.16654
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH 6.15997
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.1494
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.03291
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 5.6807
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 5.55425
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1, HSP90AA1, HSP90AB1 5.47831
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 5.46295
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TYR 5.08973
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.98958
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.96792
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 4.46264
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.3724
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.12592
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 4.06432
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.84394
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 3.82082
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.70085
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.67442
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD17B1, PTGS1, PTGS2, SRC, XDH 3.6175
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR 3.565
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, PPARG, RORC 3.5151
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, PPARG, RORC 3.5151
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARG, PTPRS, SLC1A1, SRC, TEK, TOP2A, TUBB3, XDH 3.41742
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1, PTPRS 3.19323
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.18554
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, PPARG, RORC 3.18554
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.06751
[MF] GO:0019902 phosphatase binding EGFR, HMGCR, MET, PPARA, PPARG, PTPN1, SMAD3 3.0489
[MF] GO:0042802 identical protein binding ACHE, APP, CSNK2A1, EGFR, ESR1, ESR2, FLT3, GRIK5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, PTGS2, SMAD3, TOP2A, TYR, XDH 2.96467
[MF] GO:0019899 enzyme binding APP, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, ESR2, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, MET, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A 2.96467
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARG, SLC1A1, SRC, TEK, TOP2A, TUBB3, XDH 2.93885
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.93843
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.87952
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.82826
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.82826
[MF] GO:0008389 None CYP2A13, CYP2A6 2.82826
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.72874
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.59664
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1, PTPRS 2.55362
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, PTPN1, SMAD3, SRC, TOP2A 2.48956
[MF] GO:0035258 None ESR1, FLT3, PPARG, SMAD3, SRC 2.47774
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.4342
[MF] GO:0099583 None GRM1, GRM5 2.4342
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.42411
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, PTPN1, SMAD3, SRC, TOP2A 2.36728
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.30537
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.30537
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.18002
[MF] GO:0004971 None GRIA2, GRIA4 2.18002
[MF] GO:0051425 None APP, INSR 2.18002
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, HSPA1A, KDR 2.17297
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.17221
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.1634
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.1467
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.05765
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG 2.03257
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.03061
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.00712
[MF] GO:0043559 insulin binding IGF1R, INSR 2.00712
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.00712


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.1942
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.0469
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 8.9965
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GPR35, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 8.9965
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.3181
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, SMAD3, HSP90AB1, CXCL8, FLT3, MMP1, MMP2, PTGS2, MMP9, EGFR, IGF1R, PPARG, MET 6.2904
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 7.0362
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.7585
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.1615
Bladder cancer_Homo sapiens_hsa05219 CXCL8, SRC, MMP1, MMP2, MMP9, EGFR 6.2904
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 6.2031
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.5784
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, HSP90AA1, HSP90AB1, CHRM1, INSR, KDR, TEK, MET, EGFR, IGF1R 4.4333
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.3894
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, CXCL8, INSR, GRM8, GRM1, EGFR 4.3894
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1, EGFR 3.8517
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2, PTGS1 4.2895
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 4.0947
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, PPARA, GRIA4 3.5928
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.459
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 3.3958
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 3.8891
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.0327
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.2094
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, TUBB3, GRM1, EGFR 3.459
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.0155
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, PTGS2, PTGS1 3.0308
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 CXCL8, FLT3, PPARG, MMP9, MET, IGF1R 3.0155
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR 2.6696
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.5478
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.7435
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 CXCL8, SRC, MET, EGFR 2.8579
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, EGFR, IGF1R 2.4667
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, CXCL8, MMP2, PIM1 2.2979
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, CDC25B, IGF1R 2.3348
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.0405
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.2779
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, PPARG, HMGCR, IGF1R 2.0152
Hepatitis B_Homo sapiens_hsa05161 SMAD3, CXCL8, SRC, MMP9 1.8554
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 CXCL8, FLT3, KDR, MET, EGFR 1.6718
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 1.994
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.0043
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9446
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1, CXCL8 2.0405
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.8639
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8554
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.9169
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.9259
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 1.9352
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.6377
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR 1.8639
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, PPARG, IGF1R 1.6139
Rheumatoid arthritis_Homo sapiens_hsa05323 CXCL8, MMP1, TEK 1.6377
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.461
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.1822
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CXCL8, CSNK2A1, PTGS2 1.6192
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1, HSPA1A 1.7991
Hepatitis C_Homo sapiens_hsa05160 CXCL8, PPARA, EGFR 1.2661
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 CXCL8, INSR, PPARA 1.1552
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.4365
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.1263
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, HSPA1A 1.0828
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.0903
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.1612
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2155
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2407
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2495
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.7948
Tuberculosis_Homo sapiens_hsa05152 SRC 0.249
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2602
Platelet activation_Homo sapiens_hsa04611 SRC, PTGS1 0.7469
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2806
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.2756
Phagosome_Homo sapiens_hsa04145 TUBB3 0.2806
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7622
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7622
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, CXCL8 0.8315
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.7545
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.6996
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.7622
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7397
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3181
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.8897
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.6975
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.5176
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6975
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.3201
Huntington's disease_Homo sapiens_hsa05016 GRM5, PPARG 0.536
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.7286
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.6936
Influenza A_Homo sapiens_hsa05164 CXCL8, HSPA1A 0.5781
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.9465
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6936
Axon guidance_Homo sapiens_hsa04360 MET 0.3297
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3372
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.8867
Chemokine signaling pathway_Homo sapiens_hsa04062 CXCL8, SRC 0.5493
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 0.978
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 CXCL8 0.3838
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3975
Amoebiasis_Homo sapiens_hsa05146 CXCL8 0.3975
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3975
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3975
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.3975
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4042
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0208
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.0566
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.1263
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4163
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4182
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4182
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4182
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4182
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4182
Salmonella infection_Homo sapiens_hsa05132 CXCL8 0.4182
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4182
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.4182
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.1198
Peroxisome_Homo sapiens_hsa04146 XDH 0.4182
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4173
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.1134
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1899
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4551
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.4327
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.0956
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1263
Pertussis_Homo sapiens_hsa05133 CXCL8 0.4484
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4551
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4639
Shigellosis_Homo sapiens_hsa05131 CXCL8, SRC 1.1263
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1744
Legionellosis_Homo sapiens_hsa05134 CXCL8, HSPA1A 1.2125
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 CXCL8 0.4639
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4791
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4873
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.4958
Malaria_Homo sapiens_hsa05144 CXCL8, MET 1.2935
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.2935
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.5275
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5455
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5311
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5493
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.332
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5658
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5702
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4406
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5887
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6287
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6377
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6682
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6225
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.6444
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.704
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5146
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7286
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6975
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6062
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.6682
Base excision repair_Homo sapiens_hsa03410 APEX1 0.684
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7314
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8179
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6985
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7286
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9169
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.7683
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9326


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)