TCM Prescription: Liu Gan Tea



Prescription Description
Prescription IDTCMF4451
Pinyin NameLiu Gan Cha
Chinese Name流感茶
English NameLiu Gan Tea
Function Description感冒
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1339 Phragmites communis 芦根 TCMH1339 KT695247
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH933 Talcum 滑石 TCMH933
TCMH173 Lablab niger 扁豆 TCMH173
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH2276 Elsholtzia splendens 香薷 TCMH2276 ITSAM4603-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT108 GRIA1 Glutamate receptor ionotropic, AMPA 1 Ion channel P42261
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SRC, TYR 6.90493
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.82567
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 6.68348
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HMGCR, PIM1, PPARA, TBXAS1, TYR, XDH 6.54639
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, SRC, TYR 6.51241
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PPARA, SRC, TYR 6.19086
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, ALPL, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, SRC, TYR 5.89395
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.89395
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HMGCR, HSD17B1, HSD17B2 5.54993
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIA1, GRIA2, HMGCR, HSD17B1, HSD17B2, KDR, MET, PPARA, SRC, XDH 5.25576
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.07509
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GRIA1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TBXAS1, TYR, XDH 5.05067
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 4.86472
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.62765
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.54994
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GRIA1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, SRC, TBXAS1, TYR, XDH 4.46065
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, GRIA1, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TYR 4.45784
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HMGCR, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, SRC, TYR 4.38726
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.38726
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 4.2502
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, SRC, TYR 4.11686
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.1023
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, XDH 4.04728
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 4.0383
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 3.99356
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HMGCR, HSD17B1, HSD17B2 3.98547
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 3.9801
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 3.96353
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.96333
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PPARA, SRC 3.85221
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.77987
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HMGCR, MET, PPARA, TBXAS1 3.72471
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.72471
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.71773
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 3.65553
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.61614
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.58666
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 3.58666
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 3.57857
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.50973
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 3.48983
[BP] GO:0042493 response to drug ABCG2, AKR1B1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HMGCR, KDR, SRC 3.47819
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CHRM1, CSNK2A1, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 3.46002
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TYR 3.42923
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.33888
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.22179
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIA1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.19469
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 3.17622
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.15724
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.13766
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.12409
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIA1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.12409
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.10741
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, SRC, TYR 3.05195
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 2.9102
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRIA1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 2.90682
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, AXL, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, GRIA1, MET, SRC 2.9034
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.81515
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.73207
[BP] GO:0009115 None AOX1, XDH 2.73207
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.71985
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.70893
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HMGCR, PPARA, SRC 2.69723
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.59863
[BP] GO:0080134 regulation of response to stress ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, XDH 2.59863
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.59863
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.59863
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.59863
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.59863
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, HMGCR, KDR, MET, MMP12, PPARA 2.59315
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, CNR2, ESR1, ESR2, GRIA1, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.59315
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, CNR2, ESR1, ESR2, GRIA1, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.58179
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PTPN1, SRC 2.58177
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2 2.56265
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.56265
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 2.56066
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.56066
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.54405
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GRIA1, GRIA2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TBXAS1, TYR, XDH 2.5373
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA1, GRIA2, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC 2.52728
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.51524
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.50747
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GRIA1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TBXAS1, TYR, XDH 2.46835
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, TBXAS1 2.42296
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.42296
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.39933
[BP] GO:0046110 None AOX1, XDH 2.39933
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.39933
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, GRIA1 2.39913
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, GRIA1 2.39913
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CNR1, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, XDH 2.39876
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC 2.37907
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.34224
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.34024
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.32695
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.31337
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.28661
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, GRIA1 2.2748
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.25114
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.24163
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.24163
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.24163
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 2.24107
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TBXAS1, TYR, XDH 2.23449
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CHRM1, CHRM4, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.21306
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.19603
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRIA1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 2.18802
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.17578
[BP] GO:0006145 None AOX1, XDH 2.17578
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.17578
[BP] GO:0038171 None CNR1, CNR2 2.17578
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17578
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.10555
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.10555
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CNR1, HMGCR, KDR, SRC 2.07904
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.07682
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC 2.07042
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4 2.0499
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9 2.0499
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.03878
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, GRIA1, MET 2.03629
[CC] GO:0098590 plasma membrane region ABCG2, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, GRIA1, GRIA2, MET, SRC 3.05424
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, ESR1, FLT3, GRIA1, GRIA2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC 2.73207
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, GRIA1, GRIA2, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC, TBXAS1, TYR 2.17578
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GRIA2, IGF1R, KDR, MET 2.11477
[CC] GO:0044425 membrane part ABCG2, ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, GRIA1, GRIA2, HMGCR, HSD17B2, IGF1R, KDR, MET, PTPN1, SRC, TBXAS1, TYR 1.9317
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TBXAS1, TYR, XDH 13.3221
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0954
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TBXAS1, TYR, XDH 7.11337
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TBXAS1, TYR, XDH 6.82567
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.33424
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1 5.89395
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.54993
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA1, GRIA2, IGF1R, KDR, MET, PPARA 5.24117
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.85051
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.74853
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA1, GRIA2, IGF1R, KDR, MET, PPARA 4.54199
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA1, GRIA2, IGF1R, KDR, MET, PPARA 4.38726
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD17B1, HSD17B2, XDH 4.09972
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA1, GRIA2, IGF1R, KDR, MET, PPARA 4.03047
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 3.99356
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TBXAS1, TYR, XDH 3.98547
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.96333
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.87318
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.87318
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.85221
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TBXAS1, TYR, XDH 3.70475
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.67914
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.57469
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.50973
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.48983
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.48983
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, SRC, TBXAS1, XDH 3.46002
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.25516
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.11016
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.06711
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 3.02096
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 2.9102
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 2.86909
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.73352
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.73207
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.71985
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GRIA1, GRIA2, IGF1R, KDR, MET 2.6849
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GRIA1, GRIA2, IGF1R, KDR, MET 2.6849
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.58177
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.56265
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.56066
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, GRIA1, GRIA2 2.54483
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.50431
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2 2.39933
[MF] GO:0004949 None CNR1, CNR2 2.39933
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.17578
[MF] GO:0004971 None GRIA1, GRIA2 2.17578


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.6592
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.2803
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.2551
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA1, GRIA2, CHRM1, CNR2, CNR1, ADORA3, CHRM4, ADORA1 5.6527
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.5899
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.495
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.4451
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1406
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.9755
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1406
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA1, GRIA2, CHRM1, ADORA1, PPARA 3.6552
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4 2.6238
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3595
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, MET, IGF1R 2.5879
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.2371
Long-term depression_Homo sapiens_hsa04730 GRIA1, GRIA2, IGF1R 2.3007
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 2.0849
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1704
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2371
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, MET, IGF1R 1.9122
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, ABCG2 2.1704
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.1704
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.9234
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0708
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4 1.8804
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA1, GRIA2, CNR1 1.8914
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 2.0708
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6688
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.188
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4358
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4327
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3986
Amphetamine addiction_Homo sapiens_hsa05031 GRIA1, GRIA2 1.3625
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.119
Long-term potentiation_Homo sapiens_hsa04720 GRIA1, GRIA2 1.3625
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.07
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4153
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1775
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3625
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1348
Circadian entrainment_Homo sapiens_hsa04713 GRIA1, GRIA2 1.1514
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3527
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.07
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA1, GRIA2 1.5021
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.3959
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3601
Glutamatergic synapse_Homo sapiens_hsa04724 GRIA1, GRIA2 1.0543
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2848
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.3576
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 1.0302
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.042
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.042
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.036
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA1, GRIA2 1.0007
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9322
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 1.0245
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.9469
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.95
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.8877
Nicotine addiction_Homo sapiens_hsa05033 GRIA1, GRIA2 1.6821
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM1 0.8236
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8677
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7696
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8735
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2899
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3555
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3542
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3868
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3773
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3866
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7587
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3773
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4322
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4201
Measles_Homo sapiens_hsa05162 CSNK2A1 0.458
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5375
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4501
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4622
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.454
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.476
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4622
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.504
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.476
Axon guidance_Homo sapiens_hsa04360 MET 0.4712
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0243
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5375
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5375
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5246
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4862
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5278
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8324
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5309
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5278
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5014
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5345
Gap junction_Homo sapiens_hsa04540 SRC 0.5375
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5375
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5375
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5375
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5345
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5345
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5345
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5375
Peroxisome_Homo sapiens_hsa04146 XDH 0.5375
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5756
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5924
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6117
Glioma_Homo sapiens_hsa05214 IGF1R 0.6117
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6108
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6117
Shigellosis_Homo sapiens_hsa05131 SRC 0.6117
Malaria_Homo sapiens_hsa05144 MET 0.7044
Cocaine addiction_Homo sapiens_hsa05030 GRIA2 0.7044
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7053
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7044
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7084
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.721
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8539
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.87
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.87
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8911
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8877
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1294
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9469
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.07
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3527


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)