TCM Prescription: Miao Ling Pills



Prescription Description
Prescription IDTCMF4450
Pinyin NameMiao Ling Wan
Chinese Name妙灵丸
English NameMiao Ling Pills
Function Description感冒, 风温
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH273 Fritillaria cirrhosa 川贝母 TCMH273 ITSAP3764-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH718 Aristolochia manshuriensis 关木通 TCMH718 GBVE2055-11
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH2094 Arisaema consanguineum 天南星 TCMH2094 GBVY604-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH1677 Pinellia ternata 清半夏 TCMH1677 GBVT1123-13, GBVY1693-14
TCMH695 Uncaria rhynchophylla 钩藤 TCMH695 ITSAM939-14
TCMH1179 Citri exocarpium rubrum 橘红 TCMH1179
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
TCMH2682 Cinnabaris 朱砂 TCMH2682
TCMH1294 Cornu saigae tataricae 羚羊角 TCMH1294
TCMH1997 Bubalus bubalis 水牛角 TCMH1997 GBMA0080-06
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.5546
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.7015
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 10.4618
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, TERT, XDH 10.347
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, TERT, XDH 10.3395
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, FUT7, HSPA1A, NR1H4, PIM1, PPARA, XDH 10.0217
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 9.8576
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 9.64421
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, NR1H4, PPARA, RORC, SMAD3, SRC, TEK 9.26711
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, MET, NR1H4, PPARA 8.46858
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 8.39674
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, ALPL, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR1H4, PPARA, RORC, SMAD3, SRC, TEK, TERT 8.39674
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR1H4, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, THRA, XDH 8.26738
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, CDC25B, CSNK2A1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, TERT, XDH 8.22978
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.16438
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR1H4, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, THRA, XDH 8.15224
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, IGF1R, INSR, MMP2, MMP9, NR1H4, PPARA, RORC, SRC, TEK 8.06394
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR1H4, NUAK1, PTPN1, SRC, TEK, XDH 8.02132
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, NR1H4, PPARA 7.76114
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSPA1A, INSR, KDR, MET, NR1H4, PPARA, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 7.76114
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MMP2, NR1H4, PPARA, SMAD3, SRC, TEK 7.72414
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, PIM1, PPARA, RORC, SRC, THRA, THRB 7.59859
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, SRC, THRA, THRB 7.56469
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR1H4, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, THRA 7.16655
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.05818
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CYP1B1, DRD2, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 6.97721
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.90028
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR1H4, RORC, SMAD3, SRC, TERT 6.90028
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, THRA, XDH 6.71933
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR1H4, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 6.71897
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, SRC, THRA, THRB 6.63463
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TERT, XDH 6.59409
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TERT, XDH 6.58571
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.55867
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.55867
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 6.42977
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, NR1H4, PPARA 6.41471
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.40531
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, AURKB, CDC25B, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR1H4, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 6.3962
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC, TERT 6.38935
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.36482
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR1H4, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 6.36482
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, CYP19A1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, NR1H4, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.29241
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRB, F10, FABP4, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA, THRB 6.29241
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR1H4, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, THRA, XDH 6.29241
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, SRC, TEK 6.29241
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 6.29241
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 6.29241
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 6.29241
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, THRA, XDH 6.2542
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR1H4, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 6.2542
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, THRA, XDH 6.14981
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.14981
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.14827
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.14827
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.14412
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 6.03016
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.9242
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FLT3, RORC, SRC, TEK 5.76032
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, DRD2, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.75083
[BP] GO:0030335 positive regulation of cell migration ADRA2A, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.73798
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 5.73402
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA 5.6637
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, NR1H4, RORC, SMAD3, SRC 5.64198
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 5.6294
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NR1H4, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA 5.62534
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, AXL, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, NR1H4, SMAD3, SRC, TERT 5.59251
[BP] GO:2000147 positive regulation of cell motility ADRA2A, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.58976
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, THRA, XDH 5.56793
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.56793
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR1H4, NUAK1, PTPN1, RORC, SMAD3, SRC, TERT 5.48344
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.4694
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK, TERT 5.45192
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ADRA2C, ALOX15, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, EGFR, GPR35, HSPA1A, INSR, MMP12, MMP9, NR1H4, PPARA, PTPN1, SMAD3, SRC, TERT, THRA 5.32609
[BP] GO:0040017 positive regulation of locomotion ADRA2A, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.31133
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD17B1, NR1H4 5.31018
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 5.28119
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.26295
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 5.23287
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.21834
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, INSR, KDR, PPARA, SMAD3, SRC, TEK, THRA 5.15419
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HSD17B1, NR1H4 5.14098
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, DRD2, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 5.12497
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, DRD2, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 5.09309
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, NR1H4, RORC, SRC 5.0732
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.06891
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DAO, DRD1, DRD2, EGFR, HSPA1A 4.97438
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, ADRA2C, AURKB, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.97124
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 4.9594
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.95636
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 4.95636
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, F10, INSR, MET, SRC, TEK, XDH 4.85257
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DAO, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.83893
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, NR1H4, PPARA, RORC, SRC, TEK, THRA 4.8296
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB 4.78842
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.75792
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, NR1H4, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, THRA, THRB 4.66843
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 4.66843
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 4.6528
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, NR1H4, PPARA, PTPN1, SMAD3, SRC, TEK 4.62525
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.6178
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, DRD2, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, PTPN1, SRC 4.59153
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK, THRA 4.47464
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, NR1H4, PPARA, SMAD3, TEK 4.45639
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, NR1H4, SMAD3 4.39398
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.39398
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRA2C, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.33622
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB 4.33147
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, EGFR, PPARA, SMAD3 4.32051
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA 4.30485
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CA2, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, NR1H4, PIM1, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 4.24444
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 4.2437
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 4.171
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD2, EGFR, ESRRB, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 4.15588
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 4.14778
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, NR1H4, SRC, TEK 4.12556
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TERT, THRA 4.08367
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 4.07832
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.94848
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, EGFR, ESR1, FABP4, KDR, MET, MMP12, NR1H4, PPARA, SMAD3, TEK 3.92808
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.89828
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.88772
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB 3.87066
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, DRD2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TERT, XDH 3.86166
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.80111
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, DRD1, DRD2, EGFR, KDR, NR1H4, SRC 3.78987
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.76743
[BP] GO:0032787 None ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, NR1H4, PPARA 3.75976
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C, DRD2 3.73533
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB 3.73533
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.73533
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.72851
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR, SRC, TEK 3.68364
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.68309
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.68309
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.64795
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, DRD1, DRD2, EGFR, INSR, MMP12, NR1H4, SMAD3, SRC, TERT 3.64795
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.64385
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, AXL, CA2, CYP1B1, DRD2, EGFR, ESRRB, HSPA1A, KDR, MET, MMP12, MMP9, NR1H4, PIM1, SMAD3, SRC, TEK, TERT 3.64385
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CA3, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 3.60477
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AURKB, CSNK2A1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, THRA, THRB, XDH 3.58731
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 3.58238
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, TERT 3.52853
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, MMP2, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, THRA 3.50511
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, CYP19A1, CYP1A1, CYP1B1, DAO, DRD1, DRD2, NR1H4 3.50511
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, NR1H4, PTPN1, SRC, XDH 3.49399
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.48177
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.48177
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 3.47796
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, DRD2, EGFR, ESR1, ESR2, FLT3, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.46071
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB 3.44121
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, NR1H4, SRC, TEK 3.43942
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, NR1H4, RORC, SRC 3.43942
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 3.41021
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, NR1H4, PPARA, SRC, TEK 3.4001
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 3.3633
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, HSD17B1, XDH 3.35028
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, NR1H4, PPARA, SMAD3, TEK 3.34938
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.34938
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 3.34374
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 3.34092
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 3.3148
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, DRD1, DRD2 3.29759
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 3.29665
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, DRD2, EGFR, FLT3, INSR, PTPN1, SRC, TEK 3.29665
[BP] GO:0051254 None DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB 3.2876
[BP] GO:0051172 None ADRA2A, AURKB, CSNK2A1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MMP12, MMP9, NR1H4, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, THRA, THRB, XDH 3.28374
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 3.27639
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.26556
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC 3.2601
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, RORC, SRC 3.25702
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR 3.25375
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.24824
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.24783
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, NR1H4, PPARA, SRC, TEK 3.21868
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, INSR, MMP2, MMP9, SRC, THRA, THRB 3.20186
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.20134
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, DRD1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, NR1H4, SMAD3, SRC 3.18092
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, NR1H4, SRC, TEK 3.17903
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, DRD2, EGFR, FLT3, INSR, PTPN1, SRC, TEK 3.17202
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.15992
[BP] GO:0032148 None ADRA2A, ADRA2C, INSR, SRC 3.15992
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, ADRA2C, CA2, DRD2, EGFR, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 3.15656
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DRD2, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 3.15656
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD2, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.13554
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.11607
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, NR1H4, PPARA, SRC, TEK 3.11177
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, NR1H4, PPARA, SMAD3, TEK 3.10683
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, INSR, SRC, TERT 3.1024
[BP] GO:0051952 None ADORA1, ADRA2A, ADRA2C, DRD1, DRD2 3.08808
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 3.08808
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, EGFR, ESR1, PPARA, RORC, SRC 3.05811
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRA2C, DRD2, EGFR, THRA, THRB 3.04885
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 3.03256
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 3.02996
[BP] GO:0003013 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR, SRC, TEK 3.02996
[BP] GO:0045893 None DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB 3.01774
[BP] GO:1903508 None DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB 3.01774
[BP] GO:1902680 None DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB 3.0155
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DAO, DRD1, DRD2, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.01165
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, KDR, SRC 2.99791
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, DRD2, EGFR, ESR1, FLT3, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 2.98474
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, NR1H4, PPARA, SMAD3, TEK 2.97234
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 2.95761
[BP] GO:0045934 None ADRA2A, AURKB, DRD2, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB 2.95422
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, CDC25B, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, MET, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB 2.94865
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, NR1H4, PIM1, PPARA 2.94574
[BP] GO:0033604 None ADRA2A, ADRA2C, DRD2 2.94574
[BP] GO:0008050 None THRA, THRB 2.94574
[BP] GO:0009115 None AOX1, XDH 2.94574
[BP] GO:0042493 response to drug AKR1B1, AXL, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, KDR, SRC 2.92279
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AURKB, CSNK2A1, DRD2, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP9, NR1H4, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, THRA, THRB, XDH 2.9119
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.87408
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, NR1H4, PPARA 2.87393
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, EGFR, MMP9 2.87393
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.856
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.84379
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, DRD2, EGFR, FLT3, INSR, PTPN1, SRC 2.84069
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.82854
[BP] GO:0006584 None AKR1B1, DAO, DRD1, DRD2 2.82327
[BP] GO:0009712 None AKR1B1, DAO, DRD1, DRD2 2.82327
[BP] GO:0061098 None ADORA1, ADRA2A, ADRA2C, PTPN1 2.82327
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, ADRA2C, DRD2, EGFR, GPR35, SMAD3, THRA, THRB 2.8127
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, DRD2, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.8119
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, EGFR, NR1H4 2.8119
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, ADRA2C, DRD2, EGFR, INSR, PTPN1, SRC 2.80807
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, EGFR, FLT3, PTPN1, SRC 2.75555
[BP] GO:0010628 positive regulation of gene expression DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB 2.72495
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3, THRA 2.69996
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.69996
[BP] GO:0070920 None EGFR, ESR1, TERT 2.69996
[BP] GO:0000122 None AURKB, ESR1, ESR2, ESRRA, HSPA1A, MMP12, NR1H4, PPARA, RORC, SMAD3, THRA, THRB 2.6866
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.67571
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.67317
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, GPR35, NR1H4, SMAD3 2.62489
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, EGFR, MMP9 2.61576
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.58143
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.58143
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.58143
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.58143
[BP] GO:0051179 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, EGFR, ESR1, F10, FABP3, HSPA1A, MMP12, MMP9, NR1H4, PPARA, SRC, TERT, THRA, XDH 2.56519
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CA3, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.56519
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, NR1H4, PIM1, PPARA 2.55626
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.53853
[BP] GO:0050994 None ADORA1, ADRA2A, PPARA, THRA 2.53853
[BP] GO:0046110 None AOX1, XDH 2.53853
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53853
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, ADRA2C, DRD2, EGFR, MMP12, NR1H4, SRC 2.53834
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.53434
[BP] GO:0050793 regulation of developmental process ADRA2C, AXL, CA2, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, INSR, KDR, NR1H4, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, THRA, XDH 2.52962
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, INSR, SMAD3 2.52932
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, MMP12, NR1H4, SRC 2.52932
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, ADRA2C, FLT3, PTPN1, SRC 2.5288
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.51622
[BP] GO:0007617 None DRD1, THRA, THRB 2.50791
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, NR1H4, PIM1, PPARA 2.50265
[BP] GO:0051094 positive regulation of developmental process ADRA2C, AXL, CA2, CYP1B1, DRD2, ESRRB, INSR, KDR, NR1H4, PIM1, SMAD3, SRC, TEK, TERT, THRA 2.49683
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.49683
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.49683
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.49683
[BP] GO:0051253 None AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB 2.47596
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.47425
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, ADRA2C, CYP19A1, DRD2, EGFR, NR1H4 2.46239
[BP] GO:0071880 None ADRA2A, ADRA2C, DRD2 2.45604
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, PTPN1, SRC 2.45604
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.44604
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.41832
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.39984
[BP] GO:0045892 None AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.39509
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR 2.3645
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.34124
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.34124
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.3406
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, DRD2, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK 2.33523
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.32067
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, EGFR, MMP12, NR1H4, SRC 2.30415
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.30415
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.30415
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, SRC 2.30415
[BP] GO:0035625 None ADRA2A, ADRA2C 2.30415
[BP] GO:0032811 None ADRA2A, ADRA2C 2.30415
[BP] GO:0006145 None AOX1, XDH 2.30415
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.30415
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.30415
[BP] GO:0010605 negative regulation of macromolecule metabolic process AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MMP12, MMP9, NR1H4, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, THRA, THRB, XDH 2.30415
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.30331
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.29903
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, ADRA2C, DRD2, GPR35, HSPA1A, MMP9, NR1H4, THRA 2.29578
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 2.294
[BP] GO:0010675 None ESRRB, INSR, PPARA, RORC, SRC 2.29158
[BP] GO:0046888 None ADORA1, ADRA2A, ADRA2C, DRD2 2.28537
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, CSNK2A1, DRD2, EGFR, MMP12, NR1H4, PTPN1, SMAD3, SRC, TERT, THRA 2.28182
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, DRD2, EGFR, KDR, SRC, TEK 2.28095
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.26469
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.26469
[BP] GO:0051894 None KDR, SMAD3, TEK 2.26469
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.26469
[BP] GO:0071875 None ADRA2A, ADRA2C, DRD2 2.26469
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.26469
[BP] GO:0097746 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR 2.25743
[BP] GO:0035296 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR 2.25743
[BP] GO:1903507 None AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.25743
[BP] GO:1902679 None AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.25084
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.24891
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.24625
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.24625
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, DRD1, EGFR, IGF1R, INSR, MMP2, NR1H4, SRC 2.24062
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, SRC, TERT 2.2049
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, NR1H4, PTPN1, SRC 2.20326
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.20226
[BP] GO:0035556 intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AXL, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK 2.19875
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, CA2, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, HSPA1A, MMP12, MMP2, NR1H4, PTPN1, SMAD3, SRC 2.19658
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.18274
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET 2.1811
[BP] GO:1903393 None KDR, SMAD3, TEK 2.17739
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, EGFR 2.17473
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, EGFR 2.17473
[BP] GO:0051234 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, EGFR, F10, FABP3, HSPA1A, MMP12, MMP9, NR1H4, PPARA, SRC, TERT, XDH 2.17221
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.16549
[BP] GO:0050880 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR 2.15184
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, DRD2, EGFR, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 2.14669
[BP] GO:0035150 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR 2.14049
[BP] GO:1900078 None ESRRA, NR1H4, SRC 2.14049
[BP] GO:0021853 None DRD1, DRD2 2.14049
[BP] GO:0035624 None ADRA2A, ADRA2C 2.14049
[BP] GO:0060509 None THRA, THRB 2.14049
[BP] GO:1904936 None DRD1, DRD2 2.14049
[BP] GO:0014060 None ADRA2A, ADRA2C 2.14049
[BP] GO:0042321 None ADORA1, DRD2 2.14049
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK 2.13574
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DAO, FABP3, FABP4, FUT7, HSPA1A, XDH 2.13574
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT 2.11163
[BP] GO:0007189 None ADRA2A, ADRA2C, DRD1, DRD2 2.11163
[BP] GO:0042417 None DAO, DRD1, DRD2 2.10422
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.09159
[BP] GO:0061097 None ADORA1, ADRA2A, ADRA2C, PTPN1 2.07186
[BP] GO:0050708 None ACHE, ADRA2A, ADRA2C, DRD2, EGFR, MMP12, NR1H4, SRC 2.06901
[BP] GO:0019098 None DRD1, THRA, THRB 2.06646
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C 2.06646
[BP] GO:0045088 regulation of innate immune response DRD2, ESR1, HSPA1A, MMP12, MMP2, NR1H4, PTPN1, SRC 2.06625
[BP] GO:0045944 None DRD2, EGFR, ESR1, ESRRA, ESRRB, MET, MMP12, NR1H4, PPARA, SMAD3, TERT, THRA, THRB 2.06479
[BP] GO:0032413 None ADRA2A, DRD2, GPR35, MMP9 2.05665
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, DRD2, GPR35, MMP9 2.05062
[BP] GO:0043433 negative regulation of DNA binding transcription factor activity ADORA3, CYP1B1, ESR1, NR1H4, PIM1 2.05062
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, DRD1, EGFR, IGF1R, INSR, MMP2, NR1H4, SRC 2.05062
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.03853
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, SRC 2.03512
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, AXL, CYP1A1, DRD1, EGFR, ESR1, SRC, THRA, THRB 2.03512
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, KDR, MMP2, NR1H4, SRC 2.03512
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.03431
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.03431
[BP] GO:0001775 cell activation ADRA2A, ADRA2C, ALOX5, AXL, EGFR, FLT3, FUT7, HSPA1A, MMP9, RORC, SMAD3, SRC 2.02714
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.02478
[BP] GO:0045931 positive regulation of mitotic cell cycle CDC25B, CYP1A1, DUSP3, INSR, TERT 2.02037
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, ADRA2C, CYP19A1, DRD2, EGFR, MMP12, NR1H4, SRC 2.02037
[BP] GO:0018958 None AKR1B1, DAO, DRD1, DRD2 2.01516
[BP] GO:0010629 None AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, KDR, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB, XDH 2.01516
[BP] GO:0045924 None THRA, THRB 2.01516
[BP] GO:0021843 None DRD1, DRD2 2.01516
[BP] GO:0046113 None AOX1, XDH 2.01516
[BP] GO:0021830 None DRD1, DRD2 2.01516
[BP] GO:0021826 None DRD1, DRD2 2.01516
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.01516
[BP] GO:1901890 None KDR, SMAD3, TEK 2.01516
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.01516
[BP] GO:2000352 None KDR, TEK, TERT 2.01516
[BP] GO:0045744 None ADRA2A, DRD2, MET 2.01516
[BP] GO:0001659 None ADORA1, DRD1, DRD2 2.01516
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, DRD2, EGFR, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 2.01226
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.00529
[BP] GO:0006357 None AURKB, CA9, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, TERT, THRA, THRB 2.00529
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK 3.25632
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, EGFR, ESR1, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 2.50514
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CA4, DRD1, DRD2, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.34747
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, INSR, SRC 2.07805
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AXL, CA2, CA4, CA9, DRD1, DRD2, DUSP3, EGFR, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, SRC, TEK 2.03275
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALPL, AOX1, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, THRA, THRB, XDH 2.02172
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.01516
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR1H4, PIM1, PPARA, PTPN1, RORC, SMAD3, THRA, THRB, XDH 21.5975
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 19.9673
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 15.4573
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR1H4, PPARA, PTPN1, RORC, SMAD3, THRA, THRB 12.7136
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.6181
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0888
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DUSP3, EGFR, F10, FLT3, FUT7, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TERT, XDH 10.283
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TERT, THRA, THRB, XDH 10.0466
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 9.77077
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 9.77077
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 9.06744
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TERT, THRA, THRB, XDH 8.36846
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR1H4, PPARA, RORC, TEK, THRA, THRB 7.52314
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.4236
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.41157
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 6.77041
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.6989
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.6707
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR1H4, PPARA, RORC, TEK, THRA, THRB 6.59087
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR1H4, PPARA, RORC, SMAD3, TEK, THRA, THRB 6.51865
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR1H4, PPARA, RORC, TEK, THRA, THRB 6.38935
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, THRA 5.54492
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.3752
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.33443
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, THRA 5.31133
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD1, DRD2, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK 5.26295
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, THRA, THRB 5.26295
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR1H4, RORC 5.23287
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, HSD17B1, XDH 4.26143
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.16914
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.03333
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.02473
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.97137
[MF] GO:1901338 None ADRA2A, ADRA2C, DRD1, DRD2 3.95371
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, HSD17B1, NR1H4, PPARA, RORC 3.87612
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.75125
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, HSD17B1, SRC, XDH 3.73533
[MF] GO:0004887 None NR1H4, THRA, THRB 3.68309
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, ADRA2C, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 3.56228
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.35939
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.28374
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.15992
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.94865
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.94574
[MF] GO:0008389 None CYP2A13, CYP2A6 2.94574
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TERT 2.87393
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.79108
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.7494
[MF] GO:0004935 None ADRA2A, ADRA2C, DRD2 2.69996
[MF] GO:0005102 receptor binding ADORA1, ADRA2A, ADRA2C, DAO, DRD2, EGFR, ESR1, ESR2, FLT3, HSPA1A, IGF1R, INSR, KDR, NR1H4, PTPN1, SMAD3, SRC 2.58507
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, DAO, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NR1H4, NUAK1, PIM1, SRC, TEK, XDH 2.55102
[MF] GO:0004938 None ADRA2A, ADRA2C 2.53853
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, DRD2, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.52932
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, DRD2, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.52932
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.47885
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.45604
[MF] GO:0008134 transcription factor binding ESR1, ESRRB, FLT3, NR1H4, PIM1, PPARA, SMAD3, SRC, TERT, THRA 2.42145
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, AOX1, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, SMAD3, TERT, XDH 2.36514
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.30415
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.30415
[MF] GO:0032795 None ADORA1, ADRA2A 2.30415
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.28537
[MF] GO:0043168 anion binding ALOX15, AOX1, AURKB, AXL, CSNK2A1, DAO, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NR1H4, NUAK1, PIM1, SRC, TEK, XDH 2.26469
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.17739
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.14049
[MF] GO:0043559 insulin binding IGF1R, INSR 2.14049
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, XDH 2.10854
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, XDH 2.08855
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.06646
[MF] GO:0004936 None ADRA2A, ADRA2C 2.01516
[MF] GO:0004064 arylesterase activity CA1, CA2 2.01516
[MF] GO:0043546 None AOX1, XDH 2.01516
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.01516


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.0569
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.6521
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.8202
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.6635
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.9638
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0201
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 THRB, THRA, GPR35, ADORA3, ADORA1, DRD1, ADRA2C, DRD2, ADRA2A 4.9638
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.8881
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.555
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.0988
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.42
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.1224
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 3.8881
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8729
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, CYP19A1, CYP2A6, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.0793
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.9303
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.1224
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA2C, ADRA2A 2.66
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.072
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2, EGFR 2.7089
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.4089
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.4897
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.3595
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.1812
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 THRB, THRA, SRC, ESR1 2.3402
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.1812
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.2566
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1342
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2 2.4375
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.0911
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.0589
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0864
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0542
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8236
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, DRD1, DRD2, PPARA 1.719
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8016
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.719
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.0816
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9897
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3958
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.6476
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3663
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.3595
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.374
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.0399
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0508
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9914
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0172
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2677
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15 0.901
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.036
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2476
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.8739
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3064
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0379
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8739
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8671
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8545
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8041
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1232
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.8306
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8136
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8545
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8041
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8041
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2428
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.081
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8041
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8041
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2867
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8035
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7807
Bile secretion_Homo sapiens_hsa04976 CA2, NR1H4 1.1912
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7657
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2476
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7657
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15 1.2626
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1, EGFR 0.7009
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7009
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6432
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.3958
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2845
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6169
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3094
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3253
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3188
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3183
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3188
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3091
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3542
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.5423
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3953
Platelet activation_Homo sapiens_hsa04611 SRC 0.4183
Axon guidance_Homo sapiens_hsa04360 MET 0.4105
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4183
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4478
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4478
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4645
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4717
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4717
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4759
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4803
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4799
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4845
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4978
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4978
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5081
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4973
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5424
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5423
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5274
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5334
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5547
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5696
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5677
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7387
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5737
Shigellosis_Homo sapiens_hsa05131 SRC 0.5717
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5909
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.582
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7567
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6139
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6308
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6169
Malaria_Homo sapiens_hsa05144 MET 0.6432
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6351
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO 0.6421
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6455
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6455
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7151
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6455
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.702
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9215
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7414
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.7009
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8041
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7721
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1 0.7414
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7846
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8041
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7807
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8041
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9876
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2574


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)