TCM Prescription: Pai Shi Li Dan Granules



Prescription Description
Prescription IDTCMF4444
Pinyin NamePai Shi Li Dan Ke Li
Chinese Name排石利胆颗粒
English NamePai Shi Li Dan Granules
Function Description胁痛
IndicationsHypochondrium pain disorder, Cholecystitis
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
DC12 [Cholecystitis, 胆囊炎 ];
Human Tissues Associated with IndicationLiver, Gallbladder
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH1114 Herba glechomae longitubae 金钱草 TCMH1114
TCMH1317 Gentiana scabra 龙胆 TCMH1317 ITSAP4208-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH1634 Typha angustata 蒲黄 TCMH1634 GBVX1726-13
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH2188 Trogopterus xanthipes 五灵脂 TCMH2188
TCMH1450 Natrii sulfas 芒硝 TCMH1450
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KDR, KIT, MAOA, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 16.3793
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.3793
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.3793
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIK3CA, PPARA, PTGES, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, TYR 16.3735
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TEK, XDH 15.4728
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 14.5732
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR5A, IGF1R, INSR, KDR, KIT, MMP2, PIK3CA, PPARA, PTGES, PTGS2, RELA, SMAD3, SRC, TEK, TYR 14.5732
[BP] GO:0023056 positive regulation of signaling AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 14.5732
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGES, PTGS2, RELA, SRC, TEK, TYR 14.2262
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TEK, XDH 14.1961
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 13.1056
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, AKR1C3, APP, AR, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MMP2, MMP9, NUAK1, PIM1, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 13.0382
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 13.0121
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGES, PTGS2, RELA, SRC, TYR 12.8396
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 12.8396
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, TYR 12.6624
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, TYR 12.2402
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGES, PTGS2, RELA, SRC, TEK, TYR 11.7892
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, KIT, MMP2, PPARA, PTGS2, RELA, SMAD3, SRC, TEK 11.7468
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, KIT, PPARA, PTGS2, RELA, SRC, TEK 11.6838
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B2, HSD17B3, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 11.4417
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 11.0813
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, KIT, MAP2K1, PIK3CA, PPARA, RELA, SMAD3, SRC, TEK, TYR 10.749
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PTGES, PTGS2, RELA, SRC 10.439
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 9.8202
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 9.80706
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, BCL2, CSNK2A1, EGFR, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, RELA, TEK 9.16826
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK 9.01218
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 8.71077
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MET, MMP9, PIK3CB, PPARA, PTGS2, SMAD3, SRC, TEK 8.68962
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 8.68276
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 8.64392
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSD17B3, HSPA1A, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR, XDH 8.62247
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, RELA, SMAD3, SRC 8.577
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 8.49987
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 8.4638
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 8.43674
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC, TEK 8.42212
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, PIK3CA, PTGS2, RELA, SMAD3, SRC 8.16187
[BP] GO:0009966 regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 8.10855
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PTGS2, RELA, SRC, TOP1 8.101
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B2, HSD17B3 7.91989
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, AKR1C3, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2C 7.91989
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, AR, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, SRC, TEK, XDH 7.89983
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.88354
[BP] GO:0060548 negative regulation of cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK 7.86653
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, RELA, SMAD3, SRC, TEK 7.75122
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 7.69956
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, INSR, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, TYR 7.60954
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, EGFR, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 7.50168
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, EGFR, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 7.50168
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC, TEK 7.50168
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, AR, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, SRC, TEK, XDH 7.46685
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, RELA, SRC 7.41555
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 7.40268
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TEK, TOP1, XDH 7.38926
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA2, CACNA1C, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, RELA, SMAD3, SRC, TEK 7.36929
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TOP1 7.23389
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.1815
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, AR, BCL2, CSNK2A1, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 7.1815
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, SMAD3 7.1815
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, AR, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 7.17343
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 7.15569
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.15569
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HSD17B3, HTR5A, INSR, KDR, KIT, MAP2K1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, TYR 7.09462
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B2, HSD17B3 7.09041
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MET, SRC, TEK 7.06991
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 7.05804
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MET, SRC, TEK 7.00463
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TEK, TOP1, XDH 7.0004
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.98622
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, RELA, SMAD3, SRC 6.96941
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 6.93075
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, AR, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 6.89111
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.88122
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 6.87431
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC, TEK 6.8455
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.81096
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, KIT, MMP2, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, TYR 6.80119
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGES, PTGS2 6.77922
[BP] GO:0003018 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 6.68259
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.66003
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC 6.65251
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 6.64882
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, TYR, XDH 6.61142
[BP] GO:0050790 regulation of catalytic activity ADORA3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 6.55716
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, KIT, MAP2K1, SRC 6.55716
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, AR, BCL2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 6.55094
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, AR, BCL2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TEK, XDH 6.53387
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 6.53387
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, KIT, MAP2K1, MET, PIK3CB, PIM1, SRC, TEK, TYR 6.50843
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.48657
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, AR, BCL2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TEK, XDH 6.47652
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, RELA, SRC 6.44819
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.43644
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, RELA, SMAD3, SRC, TEK 6.41402
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, AKR1C3, APP, CA2, CNR1, CNR2, ESR1, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SRC 6.41133
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, AR, BCL2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 6.40667
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PTGS2, RELA, SRC, TEK, TYR 6.40314
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, HTR1A, HTR2C, KIT, MAP2K1, MAP3K7, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK 6.36262
[BP] GO:0030334 regulation of cell migration ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.30304
[BP] GO:0019216 regulation of lipid metabolic process AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC, TEK 6.185
[BP] GO:0040012 regulation of locomotion ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, HTR1D, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.15074
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, TYR, XDH 6.13327
[BP] GO:0051270 regulation of cellular component movement ADORA3, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.13327
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 6.12059
[BP] GO:0065009 regulation of molecular function ADORA3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 6.09992
[BP] GO:0007187 None CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 6.08196
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, MAP2K1, PIK3CA, RELA, SMAD3, TYR 6.03291
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B2, HSD17B3 5.979
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PTGS2, RELA, SRC, TEK, TYR 5.92133
[BP] GO:2000145 regulation of cell motility ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.90796
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA6, CA7, CA9 5.89739
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 5.82819
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, SRC, TEK 5.79557
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CACNA1C, CNR1, EGFR, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC 5.77147
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, F3, HSPA1A, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, PTGS2, RELA, SMAD3, SRC, TEK 5.74524
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, RELA, SRC 5.70768
[BP] GO:0003013 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 5.64487
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2, HSD17B3 5.58605
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 5.58605
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, SRC 5.57335
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 5.57335
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HSD17B3, HTR1A, MAOA, TYR 5.57335
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, PIK3CB, SRC 5.56465
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, SMAD3, SRC, TEK 5.56318
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC, TEK 5.53677
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, AR, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 5.53677
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, SRC, TEK 5.53447
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, AR, EGFR, ESR1, FLT3, HTR1B, IGF1R, INSR, KIT, MMP2, PTGS2, RELA, SMAD3, SRC 5.49368
[BP] GO:0080134 regulation of response to stress APP, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MMP2, NUAK1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 5.48424
[BP] GO:0051049 regulation of transport ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, EGFR, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, MAP2K1, MMP9, PIK3CB, PPARA, PTGS2, SMAD3, SRC 5.48381
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, BCL2, CYP19A1, EGFR, ESR1, HSD17B2, HSD17B3, INSR, KIT, MAP2K1, PTGS2, SRC 5.41621
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, HSD11B2, HSD17B2, HSD17B3, INSR, KIT, MAP2K1, MMP2, MMP9, PTGS2, SRC 5.39062
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.32726
[BP] GO:0003008 None AKR1B1, AKR1C3, APP, BCL2, CNR1, CNR2, CYP1B1, EGFR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, KIT, PIK3CA, PTGS2, SRC, TEK, TYR 5.23182
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, PTGS1, PTGS2 5.21953
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, EGFR, MMP9, RELA, SRC 5.18396
[BP] GO:0097746 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.17189
[BP] GO:0035296 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.17189
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, KIT, PTGS2 5.15775
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, KIT, PTGS2 5.15775
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, RELA, SMAD3, SRC, TEK, XDH 5.11375
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, APP, AR, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 5.11028
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SMAD3, SRC, TEK 5.09072
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CNR1, CYP1B1, EGFR, ESR1, F3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIM1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 5.06324
[BP] GO:0050880 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.97944
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RELA, SRC 4.96093
[BP] GO:0035150 None EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.96093
[BP] GO:0019371 None AKR1C3, PTGES, PTGS1, PTGS2 4.95492
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, RELA, SRC 4.89156
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.85301
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, TYR, XDH 4.82994
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, SRC, TEK, TOP1 4.82994
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 4.82994
[BP] GO:0044093 positive regulation of molecular function APP, AR, AURKB, BCL2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, RELA, SMAD3, SRC, TEK, XDH 4.80246
[BP] GO:0043406 positive regulation of MAP kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, PIK3CB, SRC 4.72533
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.68683
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.63116
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.61878
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, F3, HTR2A, HTR2C, INSR, KDR, KIT, MAP2K1, PIM1, PTGS2, RELA, SMAD3, SRC, TEK 4.61222
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, CACNA1C, HTR2A, HTR2B, HTR2C, KDR, SRC 4.58786
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, RELA, SRC, TEK 4.57133
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, PTGS2, RELA, SRC, TEK 4.57133
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT 4.55944
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 4.55371
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, SRC 4.55371
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, RELA, SRC, TYR 4.55371
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.51995
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.51413
[BP] GO:0031325 positive regulation of cellular metabolic process AKR1C3, ALOX15, APP, AR, AURKB, BCL2, EGFR, ESR1, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 4.49894
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, HTR7, KIT, PPARA, SRC, TOP1 4.4679
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.44655
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, RELA, SMAD3, SRC, TEK, XDH 4.39104
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT 4.38716
[BP] GO:0051246 regulation of protein metabolic process ALOX15, APP, AR, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 4.38627
[BP] GO:0007610 None APP, BCL2, CNR1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, KIT, PPARA, PTGS2 4.38318
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, XDH 4.34883
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AR, AURKB, BCL2, CSNK2A1, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 4.34213
[BP] GO:0043549 regulation of kinase activity APP, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, SRC, TEK 4.33723
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGES, PTGS1, PTGS2 4.33723
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.33258
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 4.32457
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.29918
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.28609
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 4.24901
[BP] GO:0007154 None AKR1C3, AR, AXL, BCL2, CACNA1C, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2, TEK 4.21482
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.19477
[BP] GO:0050727 regulation of inflammatory response CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, RELA, SMAD3, TEK 4.17175
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1, HSD17B3 4.17175
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.17175
[BP] GO:0009893 positive regulation of metabolic process AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CSNK2A1, EGFR, ESR1, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 4.15266
[BP] GO:0007193 None HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.11877
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 4.11877
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 4.08017
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, EGFR, ESR1, F3, FABP4, KDR, MAP2K1, MET, PPARA, PTGS2, RELA, SMAD3, TEK 4.07558
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MAP3K7, MMP2, PPARA, PTGS2, RELA, SMAD3, SRC, TEK 4.04977
[BP] GO:0045859 regulation of protein kinase activity APP, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, SRC 4.03934
[BP] GO:0051338 regulation of transferase activity APP, AURKB, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, SRC, TEK 4.03934
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B2, HSD17B3 4.02261
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, RELA, SRC, TYR 4.01202
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MET, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.99204
[BP] GO:0009894 regulation of catabolic process BCL2, CNR1, CSNK2A1, EGFR, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PPARA, RELA, SMAD3 3.95481
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, RELA, TYR 3.94416
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.93971
[BP] GO:0071900 regulation of protein serine/threonine kinase activity DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, PIK3CB, SRC 3.93632
[BP] GO:0010648 negative regulation of cell communication ACHE, AR, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP9, PTGS2, RELA, SMAD3, SRC, XDH 3.93411
[BP] GO:0023057 negative regulation of signaling ACHE, AR, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP9, PTGS2, RELA, SMAD3, SRC, XDH 3.91571
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, SMAD3, SRC, TEK, XDH 3.90286
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, CACNA1C, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 3.8973
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.895
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 3.895
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.87036
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CNR1, CYP1A1, EGFR, PTGS2, RELA, TYR 3.87036
[BP] GO:0009895 negative regulation of catabolic process BCL2, CNR1, EGFR, HTR2B, MET, PIK3CA, PPARA, RELA, SMAD3 3.84617
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AR, AURKB, BCL2, CSNK2A1, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 3.80832
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, TYR, XDH 3.79838
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.7971
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.78925
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.77547
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, KIT, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA 3.74941
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, PTGS2, SMAD3, XDH 3.7391
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, GPR35, HTR1B, HTR2A, MMP9, PTGS2 3.73833
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, PIK3CB, SRC 3.73645
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 3.73645
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.69809
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, AR, BCL2, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP9, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 3.6387
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.62474
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, HTR1B, KDR, PTGS2, RELA, SRC 3.62474
[BP] GO:0033674 positive regulation of kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, SRC, TEK 3.59836
[BP] GO:0008217 None AR, CNR1, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 3.59594
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, SMAD3 3.5681
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, KIT, MMP9 3.52727
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.52574
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.52099
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.52099
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.52099
[BP] GO:0006693 None AKR1C3, PTGES, PTGS1, PTGS2 3.51303
[BP] GO:0006692 None AKR1C3, PTGES, PTGS1, PTGS2 3.51303
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.49344
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.49344
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.49344
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.49344
[BP] GO:0007188 None CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 3.49344
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, MAP3K7, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 3.48185
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 3.48093
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 3.46846
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.45921
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.45921
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.45385
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.44887
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, EGFR, HTR1B, HTR2A, PTGS2 3.44887
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESR1, F3, HTR2A, HTR2C, INSR, KDR, KIT, MAP2K1, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 3.43247
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, PTGS1, PTGS2 3.41446
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, HSPA1A, KIT, MAP3K7, PIM1, RELA 3.41139
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 3.38908
[BP] GO:0051347 positive regulation of transferase activity AURKB, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, SRC, TEK 3.38908
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.38707
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.38457
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, MAP2K1, PTGS2, RELA 3.37953
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR 3.37582
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, TYR, XDH 3.3758
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 3.37474
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, XDH 3.36214
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.36214
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, HTR1B, IGF1R, INSR, MMP2, PTGS2, RELA, SRC 3.36181
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 3.36181
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, INSR, KIT 3.36181
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGES, PTGS1, PTGS2 3.36181
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, MAP2K1, TEK, TYR 3.33848
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 3.33848
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.31071
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.31071
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.31071
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.31071
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.31071
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 3.29067
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, AXL, BCL2, CA2, CA9, CACNA1C, CYP1B1, EGFR, ESR1, HTR2B, INSR, MET, MMP2, RELA, SMAD3, SRC, TEK 3.26108
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.26105
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 3.26045
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, MAP3K7, PIM1, PPARA, RELA, SRC 3.22302
[BP] GO:0043269 regulation of ion transport APP, BCL2, CA2, CA7, CACNA1C, CNR1, GPR35, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 3.22288
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, RELA, SRC 3.17737
[BP] GO:0045860 positive regulation of protein kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, SRC 3.17172
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, HSD17B3 3.16448
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.15911
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, RELA, SRC, XDH 3.15302
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.14019
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.14019
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, HTR1A, MAOA 3.12561
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, HTR1A, INSR, MAOA, PTGS2, SMAD3 3.11386
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, HTR1B, IGF1R, INSR, MMP2, PTGS2, RELA, SRC 3.09767
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.08581
[BP] GO:0032870 cellular response to hormone stimulus AKR1C3, AR, EGFR, ESR1, FLT3, INSR, KIT, RELA, SRC 3.05342
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.04458
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR 3.04458
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.04458
[BP] GO:0071383 None AKR1C3, AR, EGFR, FLT3, SRC 3.03699
[BP] GO:0045759 None CNR1, CNR2, GPR35 3.03329
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA4, CA6, CA7, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, TYR, XDH 3.03148
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MMP1, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK 3.02362
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, HSD17B3, PTGES, PTGS1, PTGS2 3.01915
[BP] GO:0009892 negative regulation of metabolic process AKR1C3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PPARA, PTGS2, RELA, SMAD3, SRC, XDH 3.01267
[BP] GO:0002682 regulation of immune system process ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DUSP3, ESR1, HSPA1A, KIT, MAP3K7, MMP2, PIK3CA, PIK3CB, RELA, SMAD3, SRC 3.00614
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 3.00039
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.00039
[BP] GO:0007208 None HTR2A, HTR2C 3.00039
[BP] GO:0016488 None AKR1B10, AKR1C3 3.00039
[BP] GO:0016487 None AKR1B10, AKR1C3 3.00039
[BP] GO:0016107 None AKR1B10, AKR1C3 3.00039
[BP] GO:0006714 None AKR1B10, AKR1C3 3.00039
[BP] GO:0055065 metal ion homeostasis APP, BCL2, CACNA1C, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.9811
[BP] GO:0006952 defense response ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, KIT, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA, SRC 2.97889
[BP] GO:0009605 response to external stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HSD11B2, HTR2A, KIT, PTGES, PTGS2, RELA, SMAD3, SRC, TYR 2.97271
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.96736
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.95763
[BP] GO:0018958 None AKR1B1, BCL2, HTR1A, MAOA, TYR 2.9537
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, EGFR, ESR1, KIT, PTGS2, SRC 2.95222
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.95119
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.95119
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TOP1 2.93972
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, RELA, TYR 2.92762
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, APP, AXL, BCL2, CSNK2A1, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, RELA, SMAD3, SRC, TEK 2.91007
[BP] GO:1901570 None ALOX15, ALOX5, PTGES, PTGS1, PTGS2 2.90778
[BP] GO:0045597 positive regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CNR1, HTR2A, HTR2C, KDR, KIT, MAP2K1, PTGS2, RELA, SMAD3 2.9067
[BP] GO:0043434 None FABP3, HSD11B2, INSR, PPARA, PTGS2, RELA, SRC, TEK 2.89517
[BP] GO:0080090 regulation of primary metabolic process ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 2.88733
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, KDR, MET, PTGS2, SMAD3 2.88616
[BP] GO:0050673 epithelial cell proliferation ESR1, KIT, MAP2K1, PIK3CB, TEK 2.86103
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.85957
[BP] GO:0019725 cellular homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, SMAD3 2.85957
[BP] GO:0090066 None ALOX15, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 2.85366
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.85197
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.84495
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.84495
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.84159
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, RELA, SRC 2.83627
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.83627
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, EGFR, KIT, PTGS2, RELA, TYR 2.8318
[BP] GO:1901224 None APP, EGFR, MAP3K7, RELA 2.80915
[BP] GO:0060191 regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 2.79904
[BP] GO:0023014 signal transduction by protein phosphorylation EGFR, HTR2B, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, TEK 2.79229
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MMP9, PTGS2, RELA, SRC 2.7833
[BP] GO:1903798 None EGFR, ESR1, MAP2K1 2.77866
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.77329
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESR1, F3, INSR, KDR, KIT, MAP2K1, PIM1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 2.77219
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.76712
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.76712
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, XDH 2.74041
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.74041
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, XDH 2.72862
[BP] GO:0023052 None AR, CACNA1C, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, TEK 2.72645
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.71386
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, SMAD3, SRC, TEK 2.70731
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.70693
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.70693
[BP] GO:0070920 None EGFR, ESR1, MAP2K1 2.70693
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.70693
[BP] GO:0008285 negative regulation of cell proliferation ADORA3, APP, AR, BCL2, CYP1B1, FABP3, HSPA1A, MAP2K1, PTGES, PTGS2, SMAD3, XDH 2.70437
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 2.67736
[BP] GO:0008584 None AKR1C3, BCL2, ESR1, INSR, KIT 2.65738
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 2.65389
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MMP9, PIK3CA, PIK3CB, SMAD3, SRC 2.62331
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, EGFR, PIK3CB, PTGS2 2.61871
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.6087
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.60743
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, SRC 2.59745
[BP] GO:0033590 None EGFR, RELA 2.59745
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.59745
[BP] GO:0002520 None CACNA1C, SMAD3 2.59745
[BP] GO:0016095 None AKR1B10, AKR1C3 2.59745
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.58178
[BP] GO:0032147 activation of protein kinase activity EGFR, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, SRC 2.57765
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.57218
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, SMAD3, SRC, TEK, TOP1 2.57218
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, SMAD3, SRC, TEK, TOP1 2.57218
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.57009
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.56907
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR 2.56907
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, SMAD3, SRC, TEK, TOP1 2.55791
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR2A, INSR, KDR, MAP2K1, MET, MMP1, RELA, SMAD3, SRC, TOP1 2.54609
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, XDH 2.53827
[BP] GO:0007611 None APP, CNR1, EGFR, HTR2A, INSR, KIT, PTGS2 2.5344
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 2.53316
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.53316
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.53316
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 2.52844
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.52738
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX15, CYP19A1, HSD17B3, TYR 2.52348
[BP] GO:0007267 None AR, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, TEK 2.51779
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.51779
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.51148
[BP] GO:0031349 positive regulation of defense response CNR1, EGFR, FABP4, HSPA1A, MAP3K7, MMP2, PTGS2, RELA, SRC 2.50519
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA 2.50519
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.50309
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.50309
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.48307
[BP] GO:0098900 None CACNA1C, CNR1, CNR2, GPR35 2.47309
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, HSPA1A, RELA, SRC 2.46468
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, RELA, SMAD3, SRC, TOP1 2.46387
[BP] GO:0046890 None AKR1C3, FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.46291
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, HSPA1A, KIT, MAP3K7, RELA 2.46206
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MAOA 2.46084
[BP] GO:0050678 None AR, EGFR, F3, HTR2B, KDR, SMAD3, TEK, XDH 2.4568
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.44987
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.44987
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, RELA, SMAD3, SRC 2.44591
[BP] GO:0001889 liver development CSNK2A1, EGFR, PIK3CA, RELA, SMAD3 2.43549
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B 2.42195
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, KIT, MET, PIK3CA, PIK3CB 2.41026
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, CSNK2A1, EGFR, HSPA1A, HTR2B, HTR2C, KIT, MET, PIK3CA, PIK3CB, PTGS2, XDH 2.40872
[BP] GO:0000165 MAPK cascade EGFR, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MET, TEK 2.40303
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, NUAK1, PTGS2, XDH 2.40224
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.4005
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.4005
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, EGFR, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MET, MMP1, MMP9, PIK3CB, SMAD3, SRC, TEK 2.38017
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DUSP3, ESR1, HSPA1A, KIT, MAP3K7, MMP2, PIK3CA, PIK3CB, RELA, SMAD3, SRC 2.37884
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.37325
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.37325
[BP] GO:0050679 None AR, EGFR, F3, HTR2B, KDR, TEK 2.37325
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TEK 2.37325
[BP] GO:0035295 tube development AKR1B1, AR, CYP1A1, EGFR, KIT, SMAD3 2.37325
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC 2.361
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3 2.35514
[BP] GO:0038171 None CNR1, CNR2 2.35514
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.35514
[BP] GO:0014827 None HTR1D, HTR2B 2.35514
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.35229
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.34987
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.34965
[BP] GO:0046834 lipid phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.34395
[BP] GO:0031329 regulation of cellular catabolic process BCL2, CNR1, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PPARA 2.33159
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.29868
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.29868
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1 2.29338
[BP] GO:0046883 regulation of hormone secretion CACNA1C, CNR1, CYP19A1, EGFR, HTR1A, HTR2A, HTR2C 2.28597
[BP] GO:0050728 negative regulation of inflammatory response CNR2, CYP19A1, PPARA, SMAD3, TEK 2.27957
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.2765
[BP] GO:0051336 regulation of hydrolase activity APP, CSNK2A1, EGFR, ESR1, F3, HSPA1A, HTR2A, HTR2B, KIT, MMP9, NUAK1, PTGS2, SMAD3, SRC, XDH 2.27622
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, EGFR, ESR1, FLT3, RELA, SRC 2.26937
[BP] GO:0007423 None BCL2, CACNA1C, CYP1A1, EGFR, KIT 2.26589
[BP] GO:1901222 None APP, EGFR, MAP3K7, RELA 2.25568
[BP] GO:0051894 None KDR, SMAD3, TEK 2.25568
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.25568
[BP] GO:0007202 None EGFR, HTR2A, HTR2B 2.25568
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.25568
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.25568
[BP] GO:1903530 regulation of secretion by cell ACHE, CACNA1C, CNR1, CYP19A1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, SRC 2.24908
[BP] GO:0016042 lipid catabolic process AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.22691
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SMAD3, SRC 2.22262
[BP] GO:0050890 None APP, CNR1, EGFR, HTR2A, INSR, KIT, PTGS2 2.20874
[BP] GO:0060402 None CACNA1C, HTR2A, HTR2B, HTR2C 2.20714
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.20699
[BP] GO:0050927 None F3, KDR, SMAD3 2.20699
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, EGFR, PTGS2 2.1909
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, EGFR, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MET, PPARA, PTGS2, RELA, SMAD3, SRC 2.18707
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, RELA 2.18485
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 2.16798
[BP] GO:0010641 None F3, SRC 2.1672
[BP] GO:0007598 None F10, F3 2.1672
[BP] GO:0071502 None HTR1B, HTR2B 2.1672
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.1672
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.16587
[BP] GO:0050926 None F3, KDR, SMAD3 2.16587
[BP] GO:1903393 None KDR, SMAD3, TEK 2.16587
[BP] GO:0009612 None EGFR, HTR2A, KIT, PTGS2, RELA, SRC 2.15971
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, RELA, SMAD3, SRC 2.15562
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 2.15419
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, HTR5A, PTGS2 2.15419
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, PTGES, PTGS2, RELA, SRC 2.14099
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MAP2K1, MAP3K7, MMP9, NUAK1, PTGS2, RELA, SRC 2.12315
[BP] GO:0045913 None HTR2A, INSR, PPARA, SRC 2.12259
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 2.10698
[BP] GO:0051480 regulation of cytosolic calcium ion concentration CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 2.10511
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MMP9, PTGS2, RELA, SMAD3, SRC 2.09849
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.08018
[BP] GO:0008209 androgen metabolic process CYP19A1, ESR1, HSD17B3 2.08018
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.08018
[BP] GO:0070371 None HTR2B, KDR, MAP2K1 2.08018
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SMAD3, SRC 2.07931
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC 2.07048
[BP] GO:0046683 response to organophosphorus APP, PTGS2, RELA, TEK, TYR 2.07048
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MET, PIK3CA 2.06126
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.05722
[BP] GO:0042181 None AKR1C3, CYP19A1, HSD17B3 2.04144
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.04144
[BP] GO:0051051 negative regulation of transport APP, BCL2, CNR1, GPR35, HSPA1A, HTR1B, HTR2A, MMP9, PTGS2 2.03834
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AR, AXL, BCL2, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, HTR2B, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PTGS2, SMAD3, SRC, TEK 2.03172
[BP] GO:0001936 None F3, HTR2B, KDR, TEK, XDH 2.03105
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, IGF1R, INSR, RELA, SRC 2.02989
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.02274
[BP] GO:1990535 None APP, INSR 2.02274
[BP] GO:0014831 None HTR1D, HTR2B 2.02274
[BP] GO:0032229 None CNR2, HTR1B 2.02274
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.02274
[BP] GO:0016115 None AKR1B10, AKR1C3 2.02274
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APP, AR, AURKB, BCL2, CNR1, CSNK2A1, DUSP3, ESR1, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP9, PIK3CA, PPARA, PTGS2, RELA, SMAD3, SRC, XDH 2.01686
[BP] GO:0051046 None ACHE, CACNA1C, CNR1, CYP19A1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, SRC 2.01686
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, HSPA1A, HTR2B, MAP3K7, PTGS2, RELA, SMAD3, SRC 2.01385
[BP] GO:0001667 ameboidal-type cell migration CYP1B1, HTR2B, KDR, KIT, PIK3CA 2.01064
[BP] GO:0002209 None BCL2, HTR1A, HTR2C 2.01064
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.01064
[BP] GO:0001662 None BCL2, HTR1A, HTR2C 2.01064
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.01064
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, SMAD3, SRC, TEK 8.2248
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, TYR 8.17798
[CC] GO:0044459 plasma membrane part ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, DUSP3, EGFR, F10, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PTGS2, SRC, TEK 7.37446
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, CA4, CNR1, CNR2, F10, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 7.34919
[CC] GO:0044425 membrane part ACHE, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MET, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, SRC, TEK, TYR 6.93075
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, CNR1, CNR2, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 5.76491
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.52099
[CC] GO:0045121 membrane raft APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 3.51303
[CC] GO:0098857 membrane microdomain APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 3.49344
[CC] GO:0031224 None ACHE, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CACNA1C, CNR1, CNR2, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MET, PTGES, TEK, TYR 3.26502
[CC] GO:0098589 membrane region APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.97481
[CC] GO:0031233 None CA4, F10, F3 2.45469
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FLT3, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2 2.4005
[CC] GO:0016021 None ADORA3, ALPL, APP, AXL, CA12, CA14, CA9, CACNA1C, CNR1, CNR2, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MET, PTGES, TEK, TYR 2.30928
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2 2.28597
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, AR, AURKB, BCL2, CA2, CA4, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSPA1A, HTR2A, HTR4, HTR5A, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TOP1, TYR, XDH 2.09527
[CC] GO:0005901 caveola HTR2A, INSR, PTGS2, SRC 2.06126
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.3793
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.3793
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.3735
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.3735
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.1939
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, TYR, XDH 13.9598
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.2402
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.9701
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA6, CA7, CA9 10.1024
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK, TOP1 10.0085
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.49803
[MF] GO:0004871 signal transducer activity ADORA3, AR, AXL, CNR1, CNR2, EGFR, ESR1, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, PPARA, SMAD3, TEK 9.33487
[MF] GO:0038023 signaling receptor activity ADORA3, AR, AXL, CNR1, CNR2, EGFR, ESR1, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PPARA, TEK 9.28828
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 9.22048
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AURKB, AXL, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, SRC, TEK, TOP1, TYR, XDH 8.8799
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.65115
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, SMAD3, TYR, XDH 8.46448
[MF] GO:0004872 receptor activity ADORA3, AR, AXL, CNR1, CNR2, EGFR, ESR1, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PPARA, TEK 8.1851
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CNR1, CNR2, EGFR, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, TEK 7.92597
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CNR1, CNR2, EGFR, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, TEK 7.92597
[MF] GO:0060089 molecular transducer activity ADORA3, AR, AXL, CNR1, CNR2, EGFR, ESR1, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PPARA, TEK 7.91989
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.84308
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 7.37726
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TOP1 7.26972
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MAP3K7, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SMAD3, TYR, XDH 7.17343
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MET, SRC, TEK 7.17343
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 6.94222
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 6.40667
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.27452
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA6, CA7, CA9 5.41125
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 5.35799
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.32726
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, IGF1R, INSR, NQO2, SHBG 5.06732
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B2, HSD17B3 4.97288
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.95492
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2, HSD17B2, HSD17B3, XDH 4.89262
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B2, HSD17B3 4.82994
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 4.50221
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGES, RELA, SRC, TEK, TOP1, XDH 4.48738
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2, HSD17B2, HSD17B3 4.17175
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, MAP2K1, MAP3K7, SMAD3 4.10656
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.98176
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2, HSD17B3 3.90724
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.7927
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.70296
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 3.69536
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.61724
[MF] GO:0004930 None ADORA3, CNR1, CNR2, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.57477
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 3.55398
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 3.52099
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.51303
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.43354
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, NQO2, PTGES, PTGS1, PTGS2, SRC, XDH 3.38707
[MF] GO:0097159 organic cyclic compound binding APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RELA, SHBG, SMAD3, SRC, TEK, TOP1, XDH 3.35187
[MF] GO:0008270 zinc ion binding AR, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, SMAD3 3.31092
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 3.25222
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 3.16448
[MF] GO:1901363 heterocyclic compound binding APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TOP1, XDH 3.14417
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA6, CA7, CA9 3.09767
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, XDH 3.07841
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, XDH 3.07623
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 3.03699
[MF] GO:0036094 small molecule binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, XDH 3.03271
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 3.00039
[MF] GO:0045550 None AKR1B10, AKR1C3 3.00039
[MF] GO:0003845 None HSD11B1, HSD11B2 3.00039
[MF] GO:0071886 None HTR2A, HTR2C 3.00039
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, SRC, TEK, TOP1 2.81099
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, KIT, MAP3K7, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SMAD3, TYR, XDH 2.74218
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, XDH 2.74041
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.70693
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP9, NQO2, PTGS2, RELA, SMAD3, TYR, XDH 2.70132
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.59745
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.59745
[MF] GO:0047718 None AKR1B10, AKR1C3 2.59745
[MF] GO:0004949 None CNR1, CNR2 2.59745
[MF] GO:0047045 None AKR1C3, HSD17B3 2.59745
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, RELA, SMAD3, SRC 2.51902
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.48307
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.45209
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.44587
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.38518
[MF] GO:0005497 None AR, SHBG 2.35514
[MF] GO:0051425 None APP, INSR 2.35514
[MF] GO:0032403 protein complex binding ACHE, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, PPARA, RELA, SMAD3, SRC 2.28597
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, EGFR, MAP2K1, MAP3K7, NUAK1, PIK3CA, PIM1, TOP1 2.28597
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, F10, F3, FABP3, FABP4, HSD11B2, PPARA, SHBG 2.27547
[MF] GO:0043559 insulin binding IGF1R, INSR 2.1672
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.16587
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.16587
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.1221
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.07048
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.04144
[MF] GO:0097367 carbohydrate derivative binding APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.01385


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, HTR1E, MAOA, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, CACNA1C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 23.0599
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 10.6931
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, GPR35, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 10.6931
Pathways in cancer_Homo sapiens_hsa05200 MAP2K1, SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, RELA, IGF1R, AR, PIK3CA, KIT, BCL2, MET 9.7921
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B2, CYP1A2, CYP1A1, HSD17B3, AKR1C3, CYP1B1, CYP19A1 10.1731
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, MAP2K1, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C, PIK3CB, PPARA, HTR4, RELA 9.1116
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, PIK3CA, SRC, CNR1, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 8.8729
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA6, CA9, CA14 10.6931
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, PIK3CA, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, RELA, IGF1R 8.5558
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 8.3218
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 8.03
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, RELA, IGF1R 8.2076
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, PIK3CA, BCL2, PIK3CB, EGFR, RELA, IGF1R 7.4129
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MAP3K7, MET, EGFR, IGF1R 8.03
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3, RELA 7.0314
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, PIK3CA, INSR, KIT, KDR, BCL2, TEK, PIK3CB, MET, EGFR, RELA, IGF1R 6.8542
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, KIT, PIM1, PIK3CB, RELA 7.3991
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, CACNA1C, HTR2A, HTR5A, HTR4, EGFR 6.3276
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, KIT, PIK3CB, MET, EGFR 6.9508
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 5.9401
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9, RELA 5.9344
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, HSD17B3, AKR1C3, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 5.5522
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PIK3CB, PTGS2, PTGS1 6.0354
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.6496
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9, EGFR 6.8294
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.8674
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, SMAD3, PIK3CA, PIK3CB, EGFR, RELA 5.6955
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, MAP3K7, RELA, HSPA1A 5.5017
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, AKR1C3, PTGS2, PTGES, PTGS1 5.8422
Melanoma_Homo sapiens_hsa05218 MAP2K1, PIK3CA, PIK3CB, MET, EGFR, IGF1R 5.5522
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, RELA 5.5306
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 5.1641
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR 4.7459
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.7932
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2, EGFR 4.716
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, PIK3CA, BCL2, CACNA1C, PIK3CB 4.5305
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, HTR2B, HTR2C, HTR2A, EGFR 5.0545
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 4.3288
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, MAP3K7, RELA, HSPA1A 4.1159
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, PIK3CA, ADORA3, BCL2, PIK3CB, RELA 4.3653
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA, HSPA1A 4.1052
Glioma_Homo sapiens_hsa05214 MAP2K1, PIK3CA, PIK3CB, EGFR, IGF1R 4.5081
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, SMAD3, PIK3CA, BCL2, PIK3CB 4.5761
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.5305
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, PIK3CA, INSR, KIT, PIK3CB, EGFR 4.0096
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, SMAD3, PIK3CA, PIK3CB, RELA 4.291
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C 4.0754
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, INSR, CACNA1C, PIK3CB 3.7055
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C, EGFR 3.9161
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, DUSP3, CACNA1C, MAP3K7, EGFR, RELA, HSPA1A 3.616
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, PIK3CA, SRC, PIK3CB, EGFR 4.002
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2, RELA 4.0096
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, RELA, IGF1R 3.8642
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.092
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.6525
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.6844
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2, MAP3K7, RELA 3.8784
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, INSR, PIK3CB, PPARA, RELA 3.616
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.4323
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1 3.4599
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, MAP3K7, IGF1R 3.3786
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.1822
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.277
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR, RELA 3.2678
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA, RELA 3.0479
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, SMAD3, PIK3CA, PIK3CB, IGF1R 3.1629
Influenza A_Homo sapiens_hsa05164 MAP2K1, PIK3CA, PIK3CB, RELA, HSPA1A 2.7678
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.7235
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, PIK3CA, SRC, PIK3CB, EGFR 2.4166
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PIK3CA, SRC, PIK3CB, RELA 2.66
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2871
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.7975
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3273
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 2.0523
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, CACNA1C, PIK3CB 2.1959
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.4807
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3673
Insulin signaling pathway_Homo sapiens_hsa04910 MAP2K1, PIK3CA, INSR, PIK3CB 2.2842
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.1087
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, PIK3CA, PIK3CB, EGFR 2.7592
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.388
Axon guidance_Homo sapiens_hsa04360 MET 0.3825
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4139
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB, RELA 2.7222
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.5289
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7303
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4532
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.694
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB, RELA 1.7721
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB, RELA 1.468
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.7303
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4698
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4686
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4698
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, MAP3K7 1.4802
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.3786
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PIK3CA, PIK3CB, RELA 3.2563
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8523
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.484
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1, PIK3CA, PIK3CB 1.5337
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4985
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4855
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4953
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, PIK3CA, PIK3CB, EGFR 3.719
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4969
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.6287
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.2491
Peroxisome_Homo sapiens_hsa04146 XDH 0.5002
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5038
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.8969
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, INSR, PIK3CB 4.1159
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.2875
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5002
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, KIT, TYR 1.8468
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.515
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1, PIK3CA, PIK3CB 1.9161
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, PIK3CA, PIK3CB, EGFR 3.6212
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.9435
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, RELA 1.8468
Pertussis_Homo sapiens_hsa05133 RELA 0.524
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.517
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5262
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C, PTGS2 1.8392
Bile secretion_Homo sapiens_hsa04976 CA2 0.5361
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5262
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.1629
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR, RELA 3.3451
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.2563
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3269
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0892
Renin secretion_Homo sapiens_hsa04924 CACNA1C 0.5725
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5725
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.148
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1621
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1621
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PIK3CB 2.26
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 2.1822
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, CACNA1C, PIK3CB 3.8492
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 4.092
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.2395
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.3214
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3135
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6544
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.3542
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.3214
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6594
Malaria_Homo sapiens_hsa05144 MET 0.6643
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.3457
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2 1.3258
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3628
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4162
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.3628
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.4162
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RELA 1.3628
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6778
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6834
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.4465
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4223
Legionellosis_Homo sapiens_hsa05134 RELA, HSPA1A 1.468
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7303
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.5505
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6167
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8511
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8268
Prion diseases_Homo sapiens_hsa05020 MAP2K1, HSPA1A 1.8099
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8867
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9144
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1, EGFR 1.9905
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8742
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.8099
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8642
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9344
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7905
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.9133
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1142
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.0507
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1259
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3653


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)