TCM Prescription: Ke Tong Ding



Prescription Description
Prescription IDTCMF4414
Pinyin NameKe Tong Ding
Chinese Name克痛酊
English NameKe Tong Ding
Function Description腹痛, 跌打损伤, 痹病
IndicationsAbdominal pain disorder, Arthritis
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
Human Tissues Associated with IndicationIntestine, Stomach, SkeletalMuscle
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH843 radix kadsurae coccineae 黑老虎根 TCMH843
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH511 Litsea cubeba 豆豉姜 TCMH511 GBVG4364-11, GBVG4358-11
TCMH2267 Periploca sepium 香加皮 TCMH2267 ITSAJ4400-14, GBVP4570-15
TCMH924 Zanthoxylum bungeanum 花椒 TCMH924 ITSAJ4650-14
TCMH1165 Murraya paniculata 九里香 TCMH1165 ITSAJ1731-14
TCMH1021 Croton crassifolius 鸡骨香 TCMH1021 ITSAE1990-14
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH672 Alpinia officinarum 高良姜 TCMH672 ITSAK2176-14
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH1278 Radix zanthoxyli 两面针 TCMH1278
TCMH1982 Croton lachnocarpus 双眼龙 TCMH1982 ITSAE2014-14
TCMH1068 Dalbergia odorifera 降香 TCMH1068 ITSAJ4189-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH2585 Cinnamomum camphora 樟脑 TCMH2585 SDH069-14
TCMH189 Mentholum 薄荷脑 TCMH189
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT714 ODC1 Ornithine decarboxylase Lyase P11926
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1233 Helminthosporium
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1306 Aspergillus sp.
TCMT1308 Trichoderma
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1352 Colletotrichum truncatum
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1392 Fusarium oxysporum f. sp. niveum
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1446 Verticillium albo-atrum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR2B, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 16.4691
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR2B, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 16.4691
[BP] GO:0065008 regulation of biological quality ABCB1, ABCG2, ACHE, ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR7, INSR, KDR, KIT, MET, MIF, PPARA, PRKCD, PTAFR, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 16.2479
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2B, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 14.8384
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2B, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 14.8384
[BP] GO:0042221 response to chemical ABCB1, ABCG2, ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, HTR2B, HTR5A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PPARA, PRKCD, PTAFR, PTGES, SMAD3, SRC, TEK, TERT, TYR 14.1444
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, HTR5A, IGF1R, INSR, KDR, KIT, MMP2, PPARA, PRKCD, PTAFR, PTGES, SMAD3, SRC, TEK, TYR 13.7039
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2B, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.8561
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PTAFR, PTGES, SMAD3, SRC, TEK, TERT, XDH 12.7062
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, HTR5A, IGF1R, INSR, MMP2, MMP9, PPARA, PRKCD, PTAFR, PTGES, SRC, TEK, TYR 12.5804
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, HTR1A, HTR2B, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.0925
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2B, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.9002
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, HTR1A, HTR2B, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTAFR, PTPN1, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.5934
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2B, HTR6, INSR, KDR, KIT, MET, MIF, PTPN1, SRC, TEK, XDH 11.5342
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, GRM5, HTR5A, IGF1R, INSR, KIT, MMP2, PPARA, PRKCD, PTAFR, SMAD3, SRC, TEK 11.474
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2B, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PRKCD, PTPN1, SRC, TEK, XDH 11.474
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ALOX15, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 11.3179
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ALOX15, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 11.2243
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ALOX15, APP, BCL2, CDC25B, DRD1, EGFR, ERBB2, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, HTR2B, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 11.179
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ALOX15, APP, BCL2, CDC25B, DRD1, EGFR, ERBB2, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, HTR2B, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 11.179
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2B, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PRKCD, PTAFR, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.9099
[BP] GO:0007187 None ADORA1, ADRA2A, ADRA2C, ADRB1, CNR1, CNR2, DRD1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR6, HTR7 10.8614
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, ERBB2, F3, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT 10.6775
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DUSP3, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, HTR2B, IGF1R, INSR, KIT, MIF, MMP9, NUAK1, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 10.5551
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, HTR1A, HTR2B, HTR7, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTAFR, SMAD3, SRC, TEK, TNKS2, TYR 10.4688
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AKR1B1, APP, AXL, BCL2, CA1, CA2, CACNA1C, CNR1, CNR2, CSNK2A1, CYP1B1, DNMT1, DRD1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 10.3385
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.76537
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DUSP3, EGFR, ERBB2, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, HTR2B, IGF1R, INSR, KIT, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 9.64894
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, ADRB1, DRD1, EGFR, HMGCR, HTR1A, HTR2B, HTR7, PTAFR, SRC, TEK 9.34274
[BP] GO:0007188 None ADORA1, ADRA2A, ADRA2C, ADRB1, CNR1, DRD1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 9.3167
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, HMGCR, HTR1A, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, PTAFR, TEK, TERT 9.27646
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DRD1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.27089
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, DRD1, EGFR, ERBB2, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, HTR1A, HTR2B, INSR, MIF, MMP12, MMP9, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TERT 9.16233
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2B, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.0762
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, DRD1, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT 9.0537
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, DRD1, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT 9.0537
[BP] GO:0050896 response to stimulus ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR5A, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, SMAD3, SRC, TEK, TERT, TYR 8.93326
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PRKCD, PTAFR, SMAD3, SRC, TERT 8.8614
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, ADRB1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.78054
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2B, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 8.64817
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.61
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, DUSP3, EGFR, ERBB2, FLT3, GRM1, HMGCR, HTR2B, IGF1R, INSR, KDR, KIT, MIF, PRKCD, PTPN1, SRC, TEK, XDH 8.61
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2B, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 8.57993
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA2A, ADRA2C, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2B, INSR, KIT, MET, MIF, MMP9, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 8.57073
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, EGFR, ERBB2, FLT3, GRM1, HMGCR, HTR2B, INSR, KDR, KIT, MIF, PTPN1, SRC, TEK, XDH 8.5631
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 8.50251
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, DRD1, EGFR, ERBB2, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 8.47511
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HTR5A, INSR, KIT, PPARA, PRKCD, PTAFR, SRC, TEK 8.47028
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 8.43434
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, ADRA2A, ADRB1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HTR2B, INSR, MET, SMAD3, SRC, TERT 8.39974
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FLT3, GRM1, GRM5, HMGCR, HTR2B, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTPN1, SRC, TEK, XDH 8.39974
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADRA2A, APP, CNR1, CNR2, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 8.39974
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, ERBB2, FLT3, GRM1, HMGCR, HTR2B, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC 8.39974
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, BCL2, CYP19A1, CYP1B1, DRD1, EGFR, ERBB2, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 8.39974
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PRKCD, PTGES, SRC, TERT 8.381
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 8.27785
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, BCL2, CNR2, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 8.2769
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, BCL2, CNR1, CNR2, CYP19A1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 8.25657
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, BCL2, CNR2, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 8.25657
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, KIT, MET, MIF, PPARA, PTGES 8.14281
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, ERBB2, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP9, PPARA, PRKCD, PTPN1, SRC, TEK, XDH 8.14281
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, BCL2, CYP19A1, CYP1B1, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 8.12703
[BP] GO:0097746 None ADORA1, ADRA2A, ADRA2C, ADRB1, DRD1, EGFR, HMGCR, HTR1A, HTR2B, HTR7, PTAFR 8.09371
[BP] GO:0035296 None ADORA1, ADRA2A, ADRA2C, ADRB1, DRD1, EGFR, HMGCR, HTR1A, HTR2B, HTR7, PTAFR 8.09371
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, KIT, MMP2, PRKCD, PTAFR, SMAD3, SRC 8.08741
[BP] GO:0003013 None ADORA1, ADRA2A, ADRA2C, ADRB1, DRD1, EGFR, HMGCR, HTR1A, HTR2B, HTR7, PTAFR, SRC, TEK 8.08741
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, HTR2B, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTPN1, SRC, TEK, XDH 8.07215
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PRKCD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.06595
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRA2C, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2B, INSR, KIT, MIF, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 8.04472
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, TERT 8.04
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PRKCD, PTPN1, SMAD3, SRC, TEK, TERT 8.01889
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.99251
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.95798
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PPARA, PRKCD, PTGES, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.91384
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, HTR5A, PTAFR, PTGES, SRC, TYR 7.89716
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PRKCD, PTPN1, SRC, TEK, XDH 7.87049
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, APP, AXL, BCL2, CA2, CACNA1C, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, GPR35, GRM1, HMGCR, HSPA1A, HTR2B, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PRKCD, PTAFR, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS2, XDH 7.86989
[BP] GO:0050880 None ADORA1, ADRA2A, ADRA2C, ADRB1, DRD1, EGFR, HMGCR, HTR1A, HTR2B, HTR7, PTAFR 7.86989
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FLT3, HTR5A, PTAFR, PTGES, SRC, TEK, TYR 7.85985
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, BCL2, CYP19A1, CYP1B1, DRD1, EGFR, ERBB2, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 7.84931
[BP] GO:0035150 None ADORA1, ADRA2A, ADRA2C, ADRB1, DRD1, EGFR, HMGCR, HTR1A, HTR2B, HTR7, PTAFR 7.84741
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 7.83932
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTPN1, SRC, TEK, XDH 7.67991
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 7.62478
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 7.6124
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HMGCR, HSPA1A, HTR2B, MIF, PIM1, PPARA, PTAFR, PTGES, TYR, XDH 7.5638
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2B, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC, TEK, TNKS 7.54151
[BP] GO:0007193 None ADORA1, ADRA2A, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 7.51495
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, HTR2B, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTPN1, SRC, TEK, XDH 7.49908
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2B, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC, TEK 7.47206
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, HSPA1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, PTAFR, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 7.46759
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, EGFR, ERBB2, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK, TNKS 7.46759
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 7.4568
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CACNA1C, CNR1, DRD1, EGFR, HMGCR, HTR2B, KDR, MIF, SRC, TNKS, TNKS2 7.40674
[BP] GO:0048878 chemical homeostasis ABCG2, ADRA2A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, HTR2B, INSR, MET, SMAD3 7.40674
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PPARA, PRKCD, PTGES, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.29119
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2B, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC 7.26492
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, SMAD3, SRC, TEK, TERT 7.24265
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HMGCR, HSD17B2, HTR2B, HTR5A, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PIM1, PPARA, PRKCD, PTPRS, SMAD3, SRC, TEK, TERT, TNKS2, TYR 7.21385
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP2, MMP9, NUAK1, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TERT 7.19133
[BP] GO:0009987 cellular process ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 7.03302
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, EGFR, GRM1, GRM3, GRM5, GRM8 7.02528
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, HSPA1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, PTAFR, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 7.0058
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, KIT, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 6.99013
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, EGFR, GRM1, HMGCR, HSPA1A, HTR2B, KIT, MMP2, PPARA, PTAFR, SMAD3, SRC, TEK, TERT, TYR 6.94473
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5, PTAFR 6.92085
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.91714
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, ADRB1, APP, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESRRB, F3, HMGCR, HSPA1A, HTR2B, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PTAFR, SLC1A1, SMAD3, SRC, TEK, TERT 6.73362
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2B, INSR, KIT, MIF, PRKCD, PTPN1, SRC, TEK, TNKS 6.71535
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, PTPN1, SMAD3, SRC, TEK, TERT 6.69225
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2B, KIT, PRKCD, SRC, TEK 6.53549
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2B, INSR, KIT, MIF, PRKCD, PTPN1, SRC, TEK 6.53549
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, APP, EGFR, FLT3, GRM5, KIT, MIF, PRKCD, PTPN1, SRC 6.52328
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.47072
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 6.3749
[BP] GO:0042493 response to drug ABCB1, ABCG2, AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, EGFR, FABP3, HMGCR, HTR2B, KDR, PRKCD, PTAFR, SRC 6.22907
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FLT3, HTR1A, KIT, MET, MIF, PIM1, PRKCD, SRC, TEK, TYR 6.22713
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, ERBB2, FLT3, GRM1, HMGCR, HTR2B, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC 6.21068
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HMGCR, HSD17B1, HSD17B2, HTR1A 6.14372
[BP] GO:0035556 intracellular signal transduction ADRA2A, ADRA2C, ADRB1, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DNMT1, DRD1, EGFR, ERBB2, GRM5, HTR2B, HTR5A, IGF1R, INSR, KDR, KIT, MET, MIF, NUAK1, PRKCD, PTAFR, PTPN1, SRC, TEK 6.14372
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2B, INSR, KIT, MIF, PRKCD, PTPN1, SRC 6.08938
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.03355
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, DNMT1, DRD1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PRKCD, PTAFR, SRC, TEK, TYR 6.01755
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, DNMT1, DRD1, EGFR, ERBB2, ESR1, FLT3, GRM5, IGF1R, INSR, KIT, MMP2, PRKCD, PTAFR, SMAD3, SRC 5.95818
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5, MIF, PRKCD, PTAFR 5.93936
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, ERBB2, FLT3, GRM1, HTR2B, INSR, KIT, MIF, PTPN1, SRC 5.91548
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADRA2A, APP, BCL2, CA2, CA7, CACNA1C, CNR1, DRD1, GPR35, GRM5, HTR1A, MIF, MMP9, PRKCD, PTAFR 5.90278
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, EGFR, ERBB2, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK, TNKS 5.87057
[BP] GO:0065007 biological regulation ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.85208
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CYP19A1, DRD1, EGFR, ERBB2, HTR2B, INSR, MIF, MMP12, PRKCD, PTAFR, SMAD3, SRC, TERT 5.83954
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, MIF, MMP12, PPARA, PRKCD, PTPRS, SMAD3, TEK 5.83169
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCD, PTPN1, SRC, TNKS 5.78664
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, CNR1, CNR2, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 5.76667
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, ERBB2, HMGCR, HTR2B, KDR, MIF, PTPN1, SRC, TEK 5.76057
[BP] GO:0003008 None ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, DRD1, EGFR, GRM1, GRM5, GRM8, HMGCR, HTR1A, HTR2B, HTR7, INSR, KIT, PTAFR, SRC, TEK, TYR 5.72081
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, APP, CA2, CNR1, CNR2, DRD1, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2B, HTR5A, HTR6, HTR7, INSR, PTAFR, SRC 5.67101
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, HMGCR, HTR1A, PTAFR, TYR 5.59226
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.53596
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, DNMT1, DRD1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PRKCD, PTAFR, SRC, TEK, TYR 5.53221
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.52383
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.51609
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 5.49915
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 5.42007
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES 5.42007
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CNR1, CYP1A1, FABP3, FLT3, HMGCR, HTR2B, KIT, PPARA, PRKCD, SRC, TEK 5.38318
[BP] GO:0090066 None ADORA1, ADRA2A, ADRA2C, ADRB1, ALOX15, DRD1, EGFR, HMGCR, HTR1A, HTR2B, HTR7, PRKCD, PTAFR 5.30221
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.27305
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HMGCR, HSD17B1, HSD17B2 5.25641
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, HMGCR, HTR2B, MIF, SRC, TNKS, TNKS2 5.25641
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES 5.19638
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FUT7, HMGCR, KIT, MET, MIF, PPARA, PTGES 5.16971
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, DNMT1, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PRKCD, SMAD3, SRC, TEK, TNKS, TNKS2 5.1257
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGES, TERT 5.09135
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, INSR, KIT, MET, SRC, TEK 5.06782
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2B, KIT, PRKCD, SRC, TEK 5.06601
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.0632
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, BCL2, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 5.05809
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 4.97016
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP2, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 4.96657
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, TERT 4.92441
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, ADRA2C, APP, CA2, CACNA1C, CNR1, EGFR, ERBB2, HMGCR, HTR2B, MIF, MMP12, PRKCD, PTPN1, SMAD3, SRC 4.92441
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, INSR, KIT, MET, SRC, TEK, XDH 4.92288
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, HMGCR, KDR, PRKCD, SRC 4.92091
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.9149
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.9149
[BP] GO:0007210 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 4.9149
[BP] GO:0098664 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 4.9149
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, HMGCR, MIF, PPARA, PRKCD, PTPRS, SMAD3, TEK 4.78027
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.77669
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, ERBB2, FLT3, GRM1, HTR2B, INSR, KIT, MIF, PTPN1, SRC 4.70183
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.70183
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2B, KIT, PPARA, PRKCD, SRC, TEK 4.70183
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DNMT1, DRD1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PRKCD, PTAFR, SRC 4.69824
[BP] GO:0050801 ion homeostasis ABCG2, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, HTR2B, SMAD3 4.66294
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, ADRA2C, FLT3, GRM5, KIT, MIF, PTPN1, SRC 4.65419
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, ADRA2C, CACNA1C, CNR1, CYP19A1, EGFR, GRIK5, HMGCR, HTR1A, HTR2B, MIF, MMP12, PTAFR, SRC 4.55478
[BP] GO:0007154 None ADORA1, ADRA2C, ADRB1, AXL, BCL2, CACNA1C, CNR1, DRD1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, HTR7, SLC1A1, TEK 4.53834
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 4.53834
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, ERBB2, PPARA, SMAD3 4.53834
[BP] GO:0019932 second-messenger-mediated signaling ADRA2A, ADRA2C, ADRB1, CACNA1C, DRD1, EGFR, GRM5, HTR2B, HTR5A, KDR 4.53834
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, ESR1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, PTPN1, SRC, XDH 4.53375
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK, TNKS 4.47987
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HTR5A, INSR, KDR, KIT, MMP9, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 4.47411
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TEK 4.45288
[BP] GO:0023052 None ADORA1, ADRA2C, ADRB1, CACNA1C, CNR1, DRD1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, HTR7, SLC1A1, TEK 4.43988
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DUSP3, ERBB2, ESR1, ESRRA, HSPA1A, KIT, MIF, MMP12, MMP2, PRKCD, PTAFR, PTPN1, PTPRS, SMAD3, SRC 4.4298
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.33798
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.33798
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.31516
[BP] GO:0007267 None ADORA1, ADRA2C, ADRB1, CNR1, DRD1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, HTR7, SLC1A1, TEK 4.31516
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.27491
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2B, KIT, PTAFR 4.25074
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, HMGCR, HTR2B, KDR, MIF, SRC, TEK 4.22205
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, APP, EGFR, ERBB2, MMP9 4.22051
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PRKCD, PTAFR, SRC 4.21677
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, APP, BCL2, CACNA1C, CNR1, EGFR, ERBB2, HMGCR, HTR2B, MIF, MMP12, PRKCD, PTPN1, SMAD3, SRC 4.20933
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MET, MIF, MMP1, MMP12, MMP9, PRKCD, PTAFR, SRC, TEK 4.20428
[BP] GO:0098771 inorganic ion homeostasis ABCG2, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2B, SMAD3 4.19553
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, ADRA2C, CACNA1C, CNR1, CYP19A1, EGFR, GRIK5, HMGCR, HTR1A, HTR2B, MIF, MMP12, PTAFR, SRC 4.18735
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, APP, BCL2, CACNA1C, CNR1, CSNK2A1, EGFR, ERBB2, HMGCR, HTR2B, MIF, MMP12, PRKCD, PTPN1, SMAD3, SRC, TERT 4.18417
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, DYRK1A, EGFR, HMGCR, HSPA1A, IGF1R, MET, MIF, NUAK1, PRKCD, PTPN1, PTPRS, TERT, XDH 4.14187
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PRKCD, SRC, TEK 4.14058
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TERT 4.09892
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2B, KIT, PTAFR 4.07987
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, HTR2B, KDR, SRC 4.04982
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES 4.01444
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.99713
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 3.99713
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TERT, TNKS 3.99529
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PRKCD, SRC, TNKS, TNKS2 3.97767
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.96142
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, HSPA1A, HTR1A, KIT, MIF, MMP2, MMP9, NUAK1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, SMAD3, SRC, TEK, TERT 3.94165
[BP] GO:0097756 None ADORA1, HMGCR, HTR1A, HTR2B, HTR7 3.9247
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, HMGCR, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 3.90272
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PRKCD, PTAFR, SRC 3.89446
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APP, AURKB, BCL2, CNR1, CSNK2A1, DNMT1, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.87701
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, HTR7, KIT, PPARA, SRC 3.87603
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, APP, CACNA1C, CNR1, EGFR, ERBB2, HMGCR, HTR2B, MIF, MMP12, PRKCD, PTPN1, SMAD3, SRC 3.86111
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.86011
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PRKCD, SMAD3, TEK 3.83939
[BP] GO:0061097 None ADORA1, ADRA2A, ADRA2C, APP, GRM5, PTPN1 3.81756
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, CACNA1C, EGFR, GPR35, GRM1, KIT, PTAFR, SLC1A1, SMAD3 3.81535
[BP] GO:0045776 None ADORA1, ADRB1, CNR1, PPARA, PTAFR 3.78115
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, CSNK2A1, DNMT1, EGFR, ERBB2, ESR1, ESR2, GRIK5, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 3.77306
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AURKB, DRD1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2B, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCD, PTAFR, SMAD3, SRC, TERT, TNKS, TNKS2 3.76691
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA, PRKCD, SMAD3, TEK 3.73846
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.73846
[BP] GO:0061098 None ADORA1, ADRA2A, ADRA2C, GRM5, PTPN1 3.73846
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGES 3.73846
[BP] GO:0099536 None CNR1, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, HTR7, SLC1A1 3.70391
[BP] GO:0099537 None CNR1, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, HTR7, SLC1A1 3.70391
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B, TERT 3.69538
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 3.69357
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, ADRA2C, CACNA1C, CNR1, EGFR, HMGCR, HTR2B, MIF, MMP12, SRC 3.68968
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PRKCD, SRC, TEK 3.65435
[BP] GO:0007610 None APP, BCL2, CNR1, DRD1, EGFR, GRM1, GRM5, HMGCR, HTR1A, HTR2B, INSR, KIT, PPARA 3.65435
[BP] GO:0055080 cation homeostasis ABCG2, APP, BCL2, CA2, CA7, CACNA1C, DRD1, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2B, SMAD3 3.65435
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, MMP2, MMP9, PTAFR, SRC 3.65241
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, APP, AURKB, DNMT1, DRD1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PRKCD, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2 3.63227
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CYP1A1, DRD1, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, HMGCR, HTR2B, KDR, KIT, MET, MIF, MMP2, MMP9, PRKCD, PTPRS, SMAD3, SRC, TEK, TERT 3.59271
[BP] GO:0032409 None ABCB1, ADRA2A, APP, BCL2, GPR35, GRM5, MMP9, PRKCD, PTAFR 3.58655
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, TERT 3.57255
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.57255
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PPARA, PRKCD, SMAD3, TEK 3.54955
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, ADRA2C, EGFR, GRM1, INSR, KIT, PRKCD, PTPN1, SRC 3.54279
[BP] GO:0006928 movement of cell or subcellular component ADRA2A, APP, AXL, CNR2, CYP1B1, DRD1, EGFR, ERBB2, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PRKCD, SRC, TEK, TUBB3 3.5299
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.52204
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2B, KIT, PTAFR 3.49275
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, APP, EGFR, MMP9 3.48874
[BP] GO:0055082 cellular chemical homeostasis ABCG2, APP, BCL2, CA2, CA7, CACNA1C, DRD1, ESR1, GPR35, GRIK5, GRM1, GRM5, HTR2B, SMAD3 3.48385
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C, CNR1 3.47
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTAFR, PTGES, SRC 3.46296
[BP] GO:0030003 cellular cation homeostasis ABCG2, APP, BCL2, CA2, CA7, CACNA1C, DRD1, ESR1, GPR35, GRM1, GRM5, HTR2B, SMAD3 3.45713
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 3.45269
[BP] GO:0001775 cell activation ADRA2A, ADRA2C, ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MIF, MMP9, PRKCD, PTAFR, SMAD3, SRC 3.43345
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, EGFR, GRIK5, HTR1A, INSR, SLC1A1, SMAD3 3.42972
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, APP, AURKB, DRD1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2B, IGF1R, INSR, MET, MMP12, PPARA, PRKCD, PTAFR, SMAD3, SRC, TERT, TNKS, TNKS2 3.41613
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 3.40695
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.40468
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 3.39455
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CNR1, CNR2, CYP19A1, DUSP3, ERBB2, MIF, MMP12, PTPRS 3.39255
[BP] GO:0010676 None ESRRB, INSR, PPARA, PTAFR, SRC 3.3878
[BP] GO:0050994 None ADORA1, ADRA2A, CNR1, PPARA, PRKCD 3.3878
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.38703
[BP] GO:0006873 cellular ion homeostasis ABCG2, APP, BCL2, CA2, CA7, CACNA1C, DRD1, ESR1, GPR35, GRM1, GRM5, HTR2B, SMAD3 3.36026
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, CNR1, EGFR, HTR2B, MET, PPARA, SMAD3 3.33984
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, ADRA2C, CACNA1C, CNR1, CYP19A1, EGFR, HMGCR, HTR1A 3.33984
[BP] GO:0050793 regulation of developmental process ADRA2C, ADRB1, APP, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, HMGCR, INSR, KDR, KIT, MIF, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TERT, TNKS2, XDH 3.30393
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.29261
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, CACNA1C, DRD1, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2B, SMAD3 3.29261
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.29261
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.28565
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B, TERT 3.28565
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 3.2812
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 3.26024
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.25176
[BP] GO:0050708 None ACHE, ADRA2A, ADRA2C, CACNA1C, CNR1, EGFR, HMGCR, HTR2B, MIF, MMP12, SRC 3.24448
[BP] GO:0050890 None ADORA1, APP, CNR1, DRD1, EGFR, GRM5, HMGCR, INSR, KIT 3.24135
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, TYR, XDH 3.22682
[BP] GO:0051172 None ADRA2A, APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MIF, MMP12, MMP9, PPARA, PRKCD, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.20843
[BP] GO:0010359 None ABCB1, GRM5, PTAFR 3.20843
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, PRKCD, SRC, TEK 3.20578
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, PTAFR, SRC 3.18543
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 3.16754
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.15412
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2B, KIT, PTAFR 3.15412
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, PRKCD, PTAFR, SRC 3.1306
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HSPA1A, HTR2B, INSR, KDR, MET, PPARA, PRKCD, PTPN1, SMAD3 3.12704
[BP] GO:0034762 None ABCB1, ADRA2A, APP, BCL2, CA2, CACNA1C, DRD1, GPR35, GRM5, MMP9, PTAFR 3.12148
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C, APP 3.11533
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, HSPA1A 3.10396
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTGES, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 3.10112
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, CACNA1C, EGFR, PTAFR, SLC1A1 3.10112
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.07309
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.06141
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2B, KIT, PTAFR 3.06141
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.06141
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.03509
[BP] GO:0007268 None DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, HTR7, SLC1A1 3.0256
[BP] GO:0098916 None DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, HTR7, SLC1A1 3.0256
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, SRC, TERT 3.00114
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.00076
[BP] GO:0055065 metal ion homeostasis ABCG2, APP, BCL2, CACNA1C, DRD1, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2B, SMAD3 2.98258
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, EGFR, TNKS, TNKS2 2.97967
[BP] GO:0006940 None ADORA1, ADRA2A, ADRA2C, KIT, PTAFR 2.97155
[BP] GO:0051345 None ADRB1, APP, EGFR, ERBB2, ESR1, F3, HSPA1A, HTR2B, KIT, PRKCD, PTAFR, PTPN1, SMAD3, XDH 2.97134
[BP] GO:0042596 None ADRB1, BCL2, DRD1, HTR1A 2.96106
[BP] GO:0022898 None ABCB1, ADRA2A, APP, BCL2, GPR35, GRM5, MMP9, PTAFR 2.95667
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.95661
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, PRKCD, SRC, TNKS 2.95661
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HMGCR, MIF, PRKCD, TERT 2.92037
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CACNA1C, DRD1, ESR1, GPR35, GRM1, GRM5, HTR2B, SMAD3 2.91683
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.91556
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.91556
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PRKCD, SMAD3, XDH 2.89508
[BP] GO:0040008 regulation of growth ADRB1, APP, BCL2, CSNK2A1, EGFR, ERBB2, ESR2, HSPA1A, INSR, PIM1, PTPRS, SMAD3, TNKS2 2.89018
[BP] GO:0045913 None ESRRB, INSR, PPARA, PTAFR, SRC 2.89018
[BP] GO:1900542 None ADRA2A, ADRB1, DRD1, ESRRB, GRM3, GRM8, INSR, PPARA 2.88793
[BP] GO:0051336 regulation of hydrolase activity ADRB1, APP, CSNK2A1, EGFR, ERBB2, ESR1, F3, HSPA1A, HTR2B, KIT, MMP9, NUAK1, PRKCD, PTAFR, PTPN1, SMAD3, SRC, XDH 2.88615
[BP] GO:0007611 None APP, CNR1, DRD1, EGFR, GRM5, HMGCR, INSR, KIT 2.87685
[BP] GO:0032148 None ADRA2A, ADRA2C, INSR, SRC 2.87382
[BP] GO:0051930 None ADORA1, ADRA2C, GRM1, PTAFR 2.87382
[BP] GO:0051931 None ADORA1, ADRA2C, GRM1, PTAFR 2.87382
[BP] GO:0009115 None AOX1, XDH 2.87119
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS 2.86062
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.85441
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 2.85441
[BP] GO:0031644 None ADORA1, ADRA2C, GPR35, GRM1, PTAFR 2.84389
[BP] GO:1903524 None ADRA2C, ADRB1, EGFR, PTAFR, SLC1A1 2.84389
[BP] GO:0021885 forebrain cell migration AXL, DRD1, EGFR, HTR6 2.83134
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CACNA1C, DRD1, ESR1, GPR35, GRM1, GRM5, HTR2B, SMAD3 2.8248
[BP] GO:0050679 None EGFR, ERBB2, F3, HTR2B, KDR, MMP12, TEK 2.82034
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 2.82034
[BP] GO:0006140 None ADRA2A, ADRB1, DRD1, ESRRB, GRM3, GRM8, INSR, PPARA 2.81678
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, ERBB2, KDR, NUAK1, PPARA, PRKCD, PTAFR, SMAD3, SRC, TEK 2.80547
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, CACNA1C, DRD1, ESR1, GPR35, GRM1, GRM5, HTR2B, SMAD3 2.78761
[BP] GO:0006875 cellular metal ion homeostasis ABCG2, APP, BCL2, CACNA1C, DRD1, ESR1, GPR35, GRM1, GRM5, HTR2B, SMAD3 2.78445
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, EGFR 2.76731
[BP] GO:0060341 regulation of cellular localization ADRA2A, APP, BCL2, CACNA1C, CSNK2A1, DRD1, EGFR, ERBB2, GRIK5, HMGCR, PRKCD, PTPN1, SMAD3, SRC, TERT 2.76093
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.76085
[BP] GO:0033604 None ADRA2A, ADRA2C, CNR1 2.76085
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 2.75148
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGES 2.75148
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.72822
[BP] GO:0019725 cellular homeostasis ABCG2, APP, BCL2, CA2, CA7, CACNA1C, DRD1, ESR1, GPR35, GRIK5, GRM1, GRM5, HTR2B, SMAD3 2.71618
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, DYRK1A, PRKCD, SRC, TNKS 2.70066
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR 2.69996
[BP] GO:0051952 None ADORA1, ADRA2A, ADRA2C, CNR1, DRD1 2.69729
[BP] GO:0050678 None EGFR, ERBB2, F3, HTR2B, KDR, MMP12, SMAD3, TEK, XDH 2.67328
[BP] GO:0042060 None ALOX15, EGFR, ERBB2, PPARA, SMAD3 2.67283
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.67283
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.67255
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 2.67255
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, PRKCD, TNKS 2.64973
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, HTR1A, TYR 2.64973
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, SRC 2.64256
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIM1, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.64036
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DUSP3, ESR1, HSPA1A, KIT, MIF, MMP12, MMP2, PRKCD, PTAFR, PTPN1, PTPRS, SMAD3, SRC 2.62016
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PRKCD, SMAD3, SRC, TERT 2.62016
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.62016
[BP] GO:0051094 positive regulation of developmental process ADRA2C, APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HMGCR, INSR, KDR, KIT, PIM1, SMAD3, SRC, TEK, TERT 2.59869
[BP] GO:2000026 regulation of multicellular organismal development ADRA2C, APP, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F3, HMGCR, INSR, KDR, KIT, PIM1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 2.59129
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.59104
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, EGFR, ERBB2, HTR2B, MIF, MMP12, PRKCD, SMAD3, SRC 2.58223
[BP] GO:1903793 None ABCB1, MIF, PRKCD, PTAFR 2.56116
[BP] GO:0001816 cytokine production APP, FABP4, KIT, PRKCD, PTAFR 2.53725
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.52514
[BP] GO:0007612 None APP, DRD1, GRM5, HMGCR, INSR, KIT 2.5241
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, KIT, SRC 2.51746
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.51657
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.51657
[BP] GO:0070920 None EGFR, ESR1, TERT 2.51657
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, PRKCD, TNKS 2.49889
[BP] GO:0060191 regulation of lipase activity EGFR, ESR1, HTR2B, KIT, PTAFR 2.49889
[BP] GO:0099566 None GRM1, GRM5 2.47036
[BP] GO:0046110 None AOX1, XDH 2.47036
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47036
[BP] GO:0002520 None CACNA1C, SMAD3 2.47036
[BP] GO:0007200 None ADRA2A, DRD1, ESR1, GRM5, HTR2B 2.45971
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, SRC 2.45631
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, CNR1, GPR35, MMP9 2.45534
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.44929
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.44929
[BP] GO:0051341 None CNR1, CNR2, EGFR, HTR2B, TERT 2.4405
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, KDR, MET, MIF, SMAD3 2.43903
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, IGF1R, INSR, PRKCD, SRC 2.41731
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 2.41097
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.41027
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, SMAD3, XDH 2.39932
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.39856
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC, TERT 2.38374
[BP] GO:0051480 regulation of cytosolic calcium ion concentration CACNA1C, DRD1, ESR1, GPR35, GRM1, GRM5, HTR2B, SMAD3 2.38277
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, EGFR, HMGCR, KIT, TYR 2.38277
[BP] GO:0019933 None ADRA2A, ADRA2C, ADRB1, DRD1, HTR5A 2.38175
[BP] GO:0008150 biological_process ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 2.37953
[BP] GO:0008542 None APP, DRD1, HMGCR, KIT 2.37086
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.35666
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2, MIF, PTGES 2.35218
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.34313
[BP] GO:0008217 None ADORA1, ADRB1, CNR1, PPARA, PTAFR, SMAD3 2.34313
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.3316
[BP] GO:0050865 regulation of cell activation APP, AXL, BCL2, CNR1, CNR2, DUSP3, ERBB2, MIF, PRKCD, PTAFR, SRC 2.32802
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.32128
[BP] GO:0097755 None ADRB1, DRD1, EGFR, PTAFR 2.3121
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, PTAFR, SRC 2.302
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, SRC 2.28794
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PRKCD, PTPN1, SMAD3, SRC, TERT 2.27267
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.26954
[BP] GO:0032412 None ABCB1, ADRA2A, APP, GPR35, GRM5, MMP9, PTAFR 2.26954
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.26937
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.26937
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HTR2B, MIF, MMP12, PTAFR, SRC 2.26826
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, PTAFR, SRC 2.26647
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.26647
[BP] GO:0071880 None ADRA2A, ADRA2C, ADRB1 2.26647
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.25818
[BP] GO:0043086 negative regulation of catalytic activity ADRA2A, APP, CNR1, CNR2, CSNK2A1, DUSP3, FABP4, GRM3, HMGCR, IGF1R, MMP9, PRKCD, PTPN1, SRC 2.25818
[BP] GO:0030817 None ADRA2A, ADRB1, DRD1, GRM3, GRM8 2.25713
[BP] GO:0098900 None CACNA1C, CNR1, CNR2, GPR35 2.23224
[BP] GO:0007632 None APP, DRD1, HMGCR, KIT 2.23224
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.23224
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 2.23224
[BP] GO:0051052 regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PRKCD, SRC, TNKS, TNKS2 2.23224
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGES 2.23224
[BP] GO:0050877 None ADORA1, APP, CNR1, CNR2, CYP1B1, DRD1, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, KIT, TYR 2.23224
[BP] GO:0019935 None ADRA2A, ADRA2C, ADRB1, DRD1, HTR5A 2.23224
[BP] GO:0035625 None ADRA2A, ADRA2C 2.23224
[BP] GO:0032811 None ADRA2A, ADRA2C 2.23224
[BP] GO:0070213 None TNKS, TNKS2 2.23224
[BP] GO:0006145 None AOX1, XDH 2.23224
[BP] GO:0038171 None CNR1, CNR2 2.23224
[BP] GO:1901529 None ABCB1, PTAFR 2.23224
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.23224
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 2.22637
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, ERBB2, HTR2B, MIF, MMP12, PRKCD, SMAD3, SRC 2.22614
[BP] GO:0090257 None ADORA1, ADRA2A, ADRA2C, CACNA1C, KIT, PTAFR, SMAD3 2.22614
[BP] GO:1903959 None ABCB1, GRM5, PTAFR 2.22506
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.22506
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.22204
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.22204
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.22204
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.22204
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.22204
[BP] GO:0033555 multicellular organismal response to stress ADRB1, BCL2, DRD1, HTR1A 2.22204
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.22204
[BP] GO:0006937 None ADORA1, ADRA2A, ADRA2C, CACNA1C, KIT, PTAFR 2.20748
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.20376
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRA2A, ADRB1, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, DRD1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MMP12, PIM1, PPARA, PRKCD, PTAFR, SMAD3, SRC, TERT, TNKS, TNKS2 2.20219
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, SMAD3, SRC, TEK 2.20105
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, HMGCR, PTAFR, TYR 2.19728
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 2.19728
[BP] GO:0001819 positive regulation of cytokine production ADRA2A, CYP1B1, HSPA1A, HTR2B, MIF, MMP12, PTAFR, SMAD3, SRC 2.19728
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.18994
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.17824
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.17824
[BP] GO:0050995 None ADORA1, ADRA2A, CNR1 2.17824
[BP] GO:0051179 None ABCB1, ABCG2, ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, DRD1, EGFR, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR2B, KIT, MIF, MMP12, MMP9, PPARA, PRKCD, PTAFR, SLC1A1, SRC, TERT, TNKS, TNKS2, XDH 2.16532
[BP] GO:0045936 None ADRA2A, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PRKCD, PTPN1, XDH 2.14809
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.14326
[BP] GO:0010563 None ADRA2A, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PRKCD, PTPN1, XDH 2.14326
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, ADRA2C, APP, BCL2, CNR1, GPR35, HMGCR, HSPA1A, MMP9 2.1405
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HMGCR, KIT, MMP12, PRKCD, PTAFR, PTGES, SMAD3, SRC, TYR 2.1405
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, SMAD3, SRC, TERT, TNKS, TNKS2 2.13984
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.13973
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, TEK, TYR 2.13804
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.13804
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, KIT, MET 2.13804
[BP] GO:0043270 None ABCB1, ADORA1, ADRA2A, DRD1, MIF, PRKCD, PTAFR 2.13804
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1295
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PRKCD, PTAFR, PTGES, SMAD3, SRC 2.12915
[BP] GO:1903034 regulation of response to wounding ADRA2A, F3, HMGCR, PRKCD, PTPRS, SMAD3 2.12801
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.12727
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CYP1B1, ERBB2, FABP3, HSPA1A, PTGES, SMAD3, TERT, XDH 2.11704
[BP] GO:0008406 gonad development BCL2, CYP19A1, ESR1, INSR, KIT 2.10985
[BP] GO:0050866 negative regulation of cell activation AXL, CNR1, CNR2, DUSP3, ERBB2, PRKCD 2.1031
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.09962
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC, TERT, TNKS 2.08903
[BP] GO:0051894 None KDR, SMAD3, TEK 2.08179
[BP] GO:0071875 None ADRA2A, ADRA2C, ADRB1 2.08179
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.08179
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.08071
[BP] GO:0030168 platelet activation ADRA2A, ADRA2C, AXL, PRKCD, SRC 2.07917
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.07648
[BP] GO:0019229 None ADRA2A, ADRA2C, EGFR, PTAFR 2.07648
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, GRIK5, HMGCR, MMP9, PRKCD, SMAD3, SRC, XDH 2.07647
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, ERBB2, INSR, KDR, SMAD3, SRC 2.07558
[BP] GO:0043412 macromolecule modification ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.07268
[BP] GO:0035624 None ADRA2A, ADRA2C 2.06218
[BP] GO:0010641 None F3, SRC 2.06218
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.06218
[BP] GO:0014060 None ADRA2A, ADRA2C 2.06218
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD 2.05854
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.05854
[BP] GO:0048015 phosphatidylinositol-mediated signaling ERBB2, HTR2B, IGF1R, PTAFR 2.05854
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, DRD1, FABP3, GRIA2, GRIA4, GRIK5, HTR2B, PPARA, SLC1A1 2.05765
[BP] GO:0045934 None ADRA2A, AURKB, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, MMP12, PPARA, SMAD3, SRC, TERT, TNKS, TNKS2 2.05677
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, TEK, TERT 2.05501
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, GRIK5, HMGCR, MMP9, PRKCD, SMAD3, SRC, XDH 2.05217
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, MIF, TERT, TNKS 2.05102
[BP] GO:0050927 None F3, KDR, SMAD3 2.0475
[BP] GO:0048169 None APP, GRM5, KIT 2.0475
[BP] GO:1901342 regulation of vasculature development CYP1B1, ERBB2, F3, KDR, KIT, TEK, TERT, XDH 2.04439
[BP] GO:0019722 calcium-mediated signaling CACNA1C, EGFR, GRM5, HTR2B, KDR 2.04439
[BP] GO:0051234 None ABCB1, ABCG2, ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, DRD1, EGFR, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR2B, KIT, MIF, MMP12, MMP9, PPARA, PRKCD, PTAFR, SLC1A1, SRC, TERT, TNKS, XDH 2.03043
[BP] GO:0001817 regulation of cytokine production ADRA2A, AXL, CYP1B1, HSPA1A, HTR2B, MIF, MMP12, PTAFR, PTPRS, SMAD3, SRC 2.02789
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PTAFR, SRC 2.02286
[BP] GO:0002694 regulation of leukocyte activation APP, AXL, BCL2, CNR1, CNR2, DUSP3, ERBB2, MIF, PTAFR, SRC 2.02179
[BP] GO:0046888 None ADORA1, ADRA2A, ADRA2C, HMGCR 2.01609
[BP] GO:0034765 None ABCB1, ADRA2A, APP, CACNA1C, DRD1, GPR35, GRM5, MMP9, PTAFR 2.00467
[BP] GO:0050926 None F3, KDR, SMAD3 2.00467
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.00467
[BP] GO:1903393 None KDR, SMAD3, TEK 2.00467
[BP] GO:0007423 None BCL2, CACNA1C, CYP1A1, EGFR, KIT 2.00041
[BP] GO:0030814 None ADRA2A, ADRB1, DRD1, GRM3, GRM8 2.00041
[CC] GO:0044459 plasma membrane part ABCB1, ABCG2, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, DRD1, DUSP3, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PTAFR, PTPRS, SLC1A1, SRC, TEK 11.7305
[CC] GO:0005886 plasma membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, DRD1, EGFR, ERBB2, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP2, PIM1, PRKCD, PTAFR, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT 10.785
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, APP, AXL, BACE1, CA4, CNR1, CNR2, DRD1, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTAFR, PTPRS, SLC1A1, TEK 10.4132
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, APP, AXL, BACE1, CNR1, CNR2, DRD1, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTAFR, PTPRS, SLC1A1, TEK 9.3882
[CC] GO:0016020 membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP2, PIM1, PRKCD, PTAFR, PTGES, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR 7.36121
[CC] GO:0098590 plasma membrane region ABCB1, ABCG2, ADORA1, ADRA2A, CA2, CA4, CA9, CNR1, DRD1, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK 7.13993
[CC] GO:0044425 membrane part ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ALOX15, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PTAFR, PTGES, PTPN1, PTPRS, SLC1A1, SRC, TEK, TYR 6.15586
[CC] GO:0043005 None ADORA1, ADRA2C, APP, BACE1, CA2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2B, HTR5A, PTPRS, SRC, TUBB3 5.05982
[CC] GO:0043235 receptor complex ABCG2, ADRA2A, APP, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 5.05876
[CC] GO:0031224 None ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ALPL, APP, AXL, BACE1, CA12, CA14, CA4, CA9, CACNA1C, CNR1, CNR2, DRD1, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PTAFR, PTGES, PTPRS, SLC1A1, TEK, TYR 4.42858
[CC] GO:0120025 None ADORA1, ADRA2C, AKR1B1, APP, BACE1, CA2, CNR1, CNR2, DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2B, HTR5A, HTR6, PTPRS, SRC, TEK, TUBB3 4.39781
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.21677
[CC] GO:0042995 cell projection ADORA1, ADRA2C, AKR1B1, APP, BACE1, CA2, CNR1, CNR2, DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2B, HTR5A, HTR6, PTPRS, SRC, TEK, TUBB3 4.02685
[CC] GO:0016021 None ABCB1, ABCG2, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, ALPL, APP, AXL, BACE1, CA12, CA14, CA9, CACNA1C, CNR1, CNR2, DRD1, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PTAFR, PTGES, PTPRS, SLC1A1, TEK, TYR 4.01931
[CC] GO:0044456 None ACHE, ADORA1, ADRA2C, APP, CACNA1C, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SRC 3.81794
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, ERBB2, TEK 3.50613
[CC] GO:0097458 None ADORA1, ADRA2C, APP, BACE1, CA2, CACNA1C, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2B, HTR5A, INSR, PTPRS, SRC, TUBB3 3.46611
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.35646
[CC] GO:0043226 organelle ABCB1, ABCG2, ACHE, ADORA1, ADRA2C, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CACNA1C, CBR1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GRIA4, GRIK5, GRM1, GRM3, GRM5, HMGCR, HSPA1A, HTR5A, HTR6, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 3.31797
[CC] GO:0044464 cell part ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 3.13838
[CC] GO:0043227 membrane-bounded organelle ABCB1, ABCG2, ACHE, ADORA1, ADRA2C, ADRB1, AKR1B1, AKR1B10, ALDH2, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, HTR5A, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 2.73371
[CC] GO:0030424 None ADRA2C, APP, BACE1, CA2, CNR1, GRM3, PTPRS, TUBB3 2.64706
[CC] GO:0014069 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 2.52703
[CC] GO:0099572 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 2.52703
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, EGFR, F3, MET, MIF, TEK 2.41627
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APP, CA4, EGFR, ERBB2, HSPA1A, PRKCD, PTGES, SRC, TNKS2, TYR 2.38167
[CC] GO:0097060 None CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.36694
[CC] GO:0045121 membrane raft APP, BACE1, CNR1, EGFR, INSR, KDR, SRC, TEK 2.31338
[CC] GO:0098857 membrane microdomain APP, BACE1, CNR1, EGFR, INSR, KDR, SRC, TEK 2.29723
[CC] GO:0031982 None ABCB1, ADRA2C, ADRB1, AKR1B1, AKR1B10, ALDH2, ALPL, AOX1, APP, AXL, BACE1, CA1, CA2, CA4, CBR1, DUSP3, EGFR, F3, FABP3, FABP4, GRIA4, GRM5, HSPA1A, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTPN1, PTPRS, SLC1A1, SRC, TUBB3, TYR 2.2361
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, FLT3, GRIK5, HMGCR, HSPA1A, HTR5A, KDR, PRKCD, PTPN1, XDH 2.05217
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AXL, CNR1, CNR2, DRD1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PPARA, PTAFR, TEK 14.8384
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AXL, CNR1, CNR2, DRD1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PPARA, PTAFR, TEK 13.2984
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AXL, CNR1, CNR2, DRD1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PPARA, PTAFR, TEK 12.8857
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AXL, CNR1, CNR2, DRD1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PPARA, PTAFR, SMAD3, TEK 12.8561
[MF] GO:0043167 ion binding ABCB1, ABCG2, ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, HTR1A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 12.2161
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AXL, CNR1, CNR2, DRD1, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PTAFR, TEK 12.0925
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AXL, CNR1, CNR2, DRD1, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PTAFR, TEK 12.0925
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, TNKS, TYR, XDH 11.474
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.64894
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 9.53492
[MF] GO:0003824 catalytic activity ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, F3, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCD, PTGES, PTPN1, PTPRS, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 9.27646
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 8.61
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.59623
[MF] GO:0030594 None DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2B, HTR5A, HTR6, HTR7 8.57993
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.90733
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, INSR, KDR, KIT 7.19133
[MF] GO:0008227 None ADRA2A, ADRA2C, ADRB1, HTR1A, HTR2B, HTR5A, HTR6, HTR7 7.13993
[MF] GO:0008144 drug binding ABCB1, ABCG2, ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PPARA, PRKCD, SRC, TEK 6.27547
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.82549
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, SMAD3, TNKS 5.60645
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, ESR2, ESRRA, ESRRB, HTR1A, HTR2B, HTR5A, HTR7, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTPN1, SLC1A1, SMAD3, TERT, TNKS, TNKS2, TYR, XDH 5.55751
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 5.49915
[MF] GO:0004930 None ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, CNR1, CNR2, DRD1, GPR35, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2B, HTR5A, HTR6, HTR7, PTAFR 5.16149
[MF] GO:0042802 identical protein binding ABCG2, ACHE, ADRA2A, ADRA2C, AOX1, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP9, SMAD3, TERT, TYR, XDH 5.05477
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 4.96023
[MF] GO:0004993 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 4.9149
[MF] GO:0099589 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 4.9149
[MF] GO:0019899 enzyme binding ADRA2A, ADRB1, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, HSPA1A, KIT, MET, MIF, PPARA, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TEK, TNKS2 4.75894
[MF] GO:0043168 anion binding ABCB1, ABCG2, ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, PTAFR, PTGES, PTPRS, SLC1A1, SRC, TEK, TUBB3, XDH 4.72259
[MF] GO:0043176 None HTR1A, HTR2B, HTR5A, HTR7 4.70183
[MF] GO:0051378 None HTR1A, HTR2B, HTR5A, HTR7 4.70183
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 4.47411
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD17B1, HSD17B2, XDH 4.39959
[MF] GO:0036094 small molecule binding ABCB1, ABCG2, ADORA1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SLC1A1, SRC, TEK, TUBB3, XDH 4.32259
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, TYR, XDH 4.21677
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 3.99781
[MF] GO:0099528 None HTR1A, HTR2B, HTR5A, HTR6, HTR7 3.97596
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.92557
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET, PPARA, PTPN1, SMAD3 3.85795
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, HTR1A, HTR2B, HTR5A, HTR7 3.84778
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK, TERT 3.70414
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 3.69538
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, INSR, KDR, KIT, SMAD3 3.69357
[MF] GO:1901338 None ADRA2A, ADRA2C, ADRB1, DRD1 3.69257
[MF] GO:0000166 nucleotide binding ABCB1, ABCG2, ALDH2, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK, TUBB3, XDH 3.65435
[MF] GO:1901265 nucleoside phosphate binding ABCB1, ABCG2, ALDH2, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK, TUBB3, XDH 3.65241
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.49275
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.49275
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.47
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2B, HTR5A, HTR7 3.3878
[MF] GO:0051379 None ADRA2A, ADRA2C, ADRB1 3.35646
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.29285
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.28565
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTPN1, SLC1A1, SMAD3, TERT, TNKS, TNKS2, TYR, XDH 3.25344
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.22682
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.15412
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 3.00076
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PRKCD 2.95661
[MF] GO:0097159 organic cyclic compound binding ABCB1, ABCG2, ADORA1, ADRA2A, ADRA2C, ADRB1, ALDH2, AOX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD17B1, HSPA1A, HTR1A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, TERT, TUBB3, XDH 2.87668
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.87119
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET, PTPN1 2.82034
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ERBB2, F3, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCD, PTPN1, PTPRS, SRC, TEK 2.81151
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2 2.80404
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, PTGES, SRC, XDH 2.79876
[MF] GO:0005524 ATP binding ABCB1, ABCG2, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 2.72272
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 2.70066
[MF] GO:0046983 protein dimerization activity ABCG2, ACHE, ADORA1, ADRA2A, ADRA2C, ADRB1, AOX1, AXL, BCL2, EGFR, ERBB2, FLT3, HMGCR, KIT, SMAD3, TERT, TYR, XDH 2.62016
[MF] GO:0019838 growth factor binding EGFR, ERBB2, IGF1R, INSR, KDR, TEK 2.62016
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, ABCG2, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 2.59992
[MF] GO:0030554 adenyl nucleotide binding ABCB1, ABCG2, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 2.5646
[MF] GO:0003674 molecular_function ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTGES, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 2.56305
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ABCG2, ADORA1, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, PTAFR, PTPRS, SRC, TEK, TUBB3 2.54809
[MF] GO:0004935 None ADRA2A, ADRA2C, ADRB1 2.51657
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.49889
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 2.47551
[MF] GO:0004949 None CNR1, CNR2 2.47036
[MF] GO:0004938 None ADRA2A, ADRA2C 2.47036
[MF] GO:0099583 None GRM1, GRM5 2.47036
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.46322
[MF] GO:0031690 None ADRA2A, ADRA2C, ADRB1 2.38229
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.32128
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.32128
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, PRKCD, PTAFR, PTPN1, SMAD3, SRC 2.31236
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.30767
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.26647
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD17B1, PPARA, PTAFR 2.23224
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.23224
[MF] GO:0004971 None GRIA2, GRIA4 2.23224
[MF] GO:0032795 None ADORA1, ADRA2A 2.23224
[MF] GO:0051425 None APP, INSR 2.23224
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, GRM5, PRKCD, PTAFR, PTPN1, SMAD3, SRC 2.22614
[MF] GO:0042803 protein homodimerization activity ABCG2, ACHE, ADRA2A, ADRA2C, AOX1, BCL2, FLT3, HMGCR, KIT, SMAD3, TERT, TYR, XDH 2.19377
[MF] GO:0005515 protein binding ABCB1, ABCG2, ACHE, ADORA1, ADRA2A, ADRA2C, ADRB1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CACNA1C, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1A2, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRIA2, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, HTR1A, HTR2B, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTAFR, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 2.18994
[MF] GO:0046982 protein heterodimerization activity ADORA1, ADRA2A, ADRA2C, ADRB1, AXL, BCL2, EGFR, ERBB2, SMAD3, TYR 2.13804
[MF] GO:0005102 receptor binding ADORA1, ADRA2A, ADRA2C, ADRB1, APP, EGFR, ERBB2, ESR1, ESR2, FLT3, HSPA1A, HTR1A, IGF1R, INSR, KDR, MIF, PTPN1, SMAD3, SRC 2.09408
[MF] GO:0001540 amyloid-beta binding ACHE, BACE1, GRIA2, INSR 2.07648
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.06218
[MF] GO:0043559 insulin binding IGF1R, INSR 2.06218
[MF] GO:0051380 None ADRA2A, ADRB1 2.06218
[MF] GO:0031694 None ADRA2C, ADRB1 2.06218
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.0475
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.01609
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, ABCG2, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK, TUBB3 2.0141


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GPR35, GRIK5, PTAFR, HTR2B, HTR1A, ADRB1, HTR5A, ADRA2C, GRM1, ADRA2A, GRM3, HTR6, GRM5, HTR7, CNR2, CNR1, ADORA3, GRM8, ADORA1, DRD1, GRIA4 17.8623
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, GRM5, HTR7, PTAFR, ERBB2, HTR2B, ADRB1, CACNA1C, DRD1, HTR5A, GRM1, EGFR 8.4283
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.4283
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, ERBB2, MET, EGFR, IGF1R 8.4283
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.0696
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, PRKCD, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 7.4334
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 7.0108
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, HTR7, ALOX5, ALOX15, HTR2B, HTR1A, CACNA1C, HTR5A 7.0211
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, TUBB3, HTR2B, ADRB1, DRD1, GRM1, EGFR 6.6708
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.1049
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.0573
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, HTR6, ADORA1, HTR1A, ADRB1, CACNA1C, DRD1, PPARA, GRIA4 5.095
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 4.9492
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, KIT, ERBB2, BCL2, MMP9, MET, EGFR, IGF1R 4.4261
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.2208
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, ERBB2, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 4.6925
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, ADRB1, MET, EGFR, IGF1R, HSPA1A 4.3259
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, ALOX15, AKR1B1, HMGCR, TYR, CYP19A1, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 4.2231
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PRKCD, BCL2, PIM1, F3 4.0989
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, KIT, GRM8, GRM1, EGFR 4.2231
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1 4.7775
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 3.9555
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CNR1, CACNA1C, GRM1, GRIA4 4.0989
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRB1, CACNA1C, ADRA2C, ADRA2A 3.9108
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, ERBB2, BCL2, TEK, EGFR, IGF1R 4.0692
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, MET, EGFR, IGF1R 3.4158
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, ERBB2, MET, EGFR 3.8945
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCD, CACNA1C, EGFR 3.284
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KIT, KDR, BCL2, TEK, MET, EGFR, IGF1R 2.8441
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, ADRB1 3.0101
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.6467
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, CACNA1C, DRD1, GRIA4 2.7775
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGES 2.8671
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 2.7897
Prostate cancer_Homo sapiens_hsa05215 ERBB2, BCL2, EGFR, IGF1R 2.4013
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 2.6714
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, ABCG2 2.7058
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7409
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PRKCD, PPARA 2.1056
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 2.5137
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, CACNA1C, DRD1, GRIA4 1.8817
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 1.761
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, CACNA1C, EGFR, CDC25B, HSPA1A 1.6162
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.5764
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 1.9801
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.8817
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5105
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 1.9348
Taste transduction_Homo sapiens_hsa04742 HTR1A, CACNA1C, GRM1 1.6304
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.7878
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.7788
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, ERBB2, EGFR 1.8608
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.5959
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 1.9465
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, CACNA1C 1.3639
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCD, HTR2B 1.4957
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 1.8817
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.5191
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8324
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 1.8713
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.3063
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, PRKCD, CACNA1C 2.1652
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.2932
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.2633
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.1148
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCD 1.167
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.1502
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1 2.1493
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.0649
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.0649
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP, CACNA1C 1.0091
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 0.8595
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.1987
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2119
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2207
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2294
Alcoholism_Homo sapiens_hsa05034 DRD1 0.2272
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2294
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2623
Phagosome_Homo sapiens_hsa04145 TUBB3 0.2623
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.2814
Apoptosis_Homo sapiens_hsa04210 BCL2 0.2832
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.2941
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.5522
Axon guidance_Homo sapiens_hsa04360 MET 0.3082
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.4523
Platelet activation_Homo sapiens_hsa04611 SRC 0.3158
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD, BCL2 0.7165
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3158
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7203
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.3939
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6096
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7203
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5321
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.6668
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8351
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7075
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6444
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.671
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.6554
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3467
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCD, CACNA1C 0.7165
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC, PRKCD 0.5105
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.8242
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.8684
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.8573
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.8798
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3627
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.8798
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.8722
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 0.8722
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.8595
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3699
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3699
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3827
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3817
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCD 0.3872
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9578
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.3943
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4033
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3943
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.402
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.3939
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4007
Peroxisome_Homo sapiens_hsa04146 XDH 0.4046
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4075
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4282
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4046
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4151
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4135
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4168
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4282
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.5251
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.0749
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4394
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4282
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1148
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.0431
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4523
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.1071
Shigellosis_Homo sapiens_hsa05131 SRC 0.4542
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.4542
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.4523
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.167
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.2099
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5038
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.5105
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5074
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.22
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5074
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.519
Malaria_Homo sapiens_hsa05144 MET 0.5321
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.2633
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.5308
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5447
ABC transporters_Homo sapiens_hsa02010 ABCB1, ABCG2 1.3105
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.5496
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.5522
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.3764
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.5566
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.5969
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5769
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6326
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.5904
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.5959
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6668
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7075
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5363
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.6668
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6824
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7075
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.761
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7075
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.7075
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.7203
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.751
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.8453
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.8854
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.8671
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1782


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)