TCM Prescription: Huo Xue Tong Mai Tablets



Prescription Description
Prescription IDTCMF4409
Pinyin NameHuo Xue Tong Mai Pian
Chinese Name活血通脉片
English NameHuo Xue Tong Mai Tablets
Function Description胸痹
IndicationsChest pain
Disease ICD-11 Category MD30.Z [Chest pain, unspecified, 胸痛，未特指的 ];
Human Tissues Associated with IndicationHeart, Lung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1068 Dalbergia odorifera 降香 TCMH1068 ITSAJ4189-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KCNH2, KDR, MAOA, MET, MIF, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS1, PTGS2, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 14.0445
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, CDC25B, CHRM1, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PTAFR, PTGES, PTGS1, PTGS2, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 12.5227
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 12.5227
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, HSD17B3, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 12.5227
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 12.5227
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TEK, XDH 11.6193
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FUT7, HMGCR, HSD17B3, HSPA1A, MIF, PIK3CA, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, TYR, XDH 11.3397
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, MIF, PTGES, PTGS1, PTGS2 11.2571
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 11.1696
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 11.0136
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, MIF, PTGES, PTGS1, PTGS2 11.0136
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 10.8706
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 10.7975
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TEK, TYR 10.5602
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 10.3501
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TEK, XDH 10.1367
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, CHRM5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.99464
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, CHRM5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.92578
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGES, PTGS1, PTGS2 9.83933
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.75682
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.3845
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AXL, CA2, CA7, CACNA1C, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 9.35528
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 9.32052
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.14594
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.14594
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AXL, CACNA1C, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTAFR, PTGS2, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TYR 9.12566
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, MIF, PTGES, PTGS1, PTGS2 9.07885
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 8.88302
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, HMGCR, HSD17B1, HSD17B2, HSD17B3 8.8408
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, MIF, PPARA, PTGES, PTGS1, PTGS2 8.83616
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 8.83425
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA6, CA9, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 8.73634
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 8.71982
[BP] GO:0007193 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 8.49759
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, PTAFR, PTGS2, RELA, RORC, SLC6A4, SMAD3, SRC, TERT 8.38997
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, APP, AR, AXL, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTAFR, PTGS2, RELA, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 8.30149
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 8.26016
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, AR, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MIF, PIK3CB, PTPN1, SRC, TEK, XDH 8.1901
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, CDC25B, CHRM1, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTAFR, PTGS2, RELA, TEK, TERT 8.13057
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, PTGS2, RELA, SLC6A4, SMAD3, SRC, TEK 7.99186
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, ESRRB, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.94414
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MIF, MMP2, MMP9, NUAK1, PIK3CA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TERT 7.62371
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.62371
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.62371
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.59037
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT 7.55575
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 7.55575
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT 7.55176
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, AR, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, PIK3CB, PTPN1, SRC, TEK, XDH 7.47066
[BP] GO:0033993 response to lipid AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PTAFR, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TYR 7.44828
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGES, PTGS1, PTGS2 7.44828
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 7.44828
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, APP, AXL, CA2, CA7, CACNA1C, CHRM1, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, INSR, KCNH2, MAP2K1, MIF, MMP12, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT 7.44828
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, PTAFR, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TEK, TYR 7.41708
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 7.41266
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HMGCR, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 7.3448
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, PTAFR, PTGS2, RELA, SLC6A4, SRC, TEK 7.33045
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AXL, CA1, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK 7.33045
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGES, PTGS2, RELA, SRC, TERT 7.17091
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, PIK3CA, PPARA, RELA, SMAD3, SRC, TEK, TYR 7.17091
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PIK3CB, PTPN1, SRC 7.15291
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 7.02854
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.98845
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT 6.98845
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, APP, AR, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.98845
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, PIK3CA, PTAFR, PTGS2, RELA, RORC, SLC6A4, SMAD3, SRC 6.98845
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, NQO2, PTGS1, RORC 6.98845
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 6.98845
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, XDH 6.97994
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.91339
[BP] GO:0003018 None ADORA1, ADRA2A, CHRM1, CHRM3, EGFR, HMGCR, PTAFR, PTGS2, SLC6A4, SRC, TEK 6.91339
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, APP, AR, AXL, CA2, CHRM3, CYP1B1, EGFR, ESRRB, F3, HCAR2, HMGCR, HSPA1A, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIM1, PTAFR, PTGS2, RELA, SLC1A1, SMAD3, SRC, TEK, TERT 6.89911
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MAP2K1, MAP3K7, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 6.89338
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 6.83723
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, CHRM1, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.73729
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 6.72569
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, CACNA1C, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.71949
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.65782
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 6.65782
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.62513
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.61614
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, XDH 6.57227
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTAFR, PTGS2, RELA, RORC, SLC6A4, SRC 6.49683
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA9, CACNA1C, CBR1, CDC25B, CES1, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HMGCR, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 6.49344
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.46539
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 6.45206
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 6.41147
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 6.40425
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, APP, AR, AURKB, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MAP2K1, MAP3K7, MET, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 6.37008
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.31123
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TEK, XDH 6.22705
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, MIF, PPARA, PTGES, PTGS1, PTGS2 6.21454
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2, HSD17B3, MIF, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 6.20205
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.20205
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, PTPN1, SRC 6.20205
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APP, AXL, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 6.1347
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.12554
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 6.0571
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2, SLC6A4 6.04258
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2, SLC6A4 6.04258
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MAP3K7, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, RELA, SMAD3, SRC, TEK 6.04258
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 6.02718
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MAP2K1, MET, MIF, PIK3CB, PIM1, SRC, TEK, TYR 5.97418
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.97418
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 5.91171
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 5.90682
[BP] GO:0007188 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.88477
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.86176
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.86076
[BP] GO:0003013 None ADORA1, ADRA2A, CHRM1, CHRM3, EGFR, HMGCR, PTAFR, PTGS2, SLC6A4, SRC, TEK 5.84752
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, CACNA1C, CHRM1, CHRM2, CHRM3, EGFR, GPR35, GRM1, HCAR2, KCNH2, PTAFR, PTGS2, SLC1A1, SMAD3 5.81726
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.8116
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, GRM1, INSR, MAP2K1, MAP3K7, MIF, PIK3CB, PTPN1, SRC 5.74226
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.73259
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3 5.71448
[BP] GO:0097746 None ADORA1, ADRA2A, CHRM1, CHRM3, EGFR, HMGCR, PTAFR, PTGS2, SLC6A4 5.62903
[BP] GO:0035296 None ADORA1, ADRA2A, CHRM1, CHRM3, EGFR, HMGCR, PTAFR, PTGS2, SLC6A4 5.62903
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.51398
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 5.5033
[BP] GO:0050880 None ADORA1, ADRA2A, CHRM1, CHRM3, EGFR, HMGCR, PTAFR, PTGS2, SLC6A4 5.40856
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, AR, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, RELA, SLC6A4, SMAD3, SRC, TERT, XDH 5.40856
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, CACNA1C, CHRM1, CHRM2, CHRM3, EGFR, KCNH2, PTAFR, PTGS2, SLC1A1 5.40856
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, APP, CES1, CYP19A1, CYP1A1, CYP1B1, HMGCR, HSD17B3, MAOA, PTAFR, TYR 5.4
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, AR, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, RELA, SLC6A4, SMAD3, SRC, TERT, XDH 5.39106
[BP] GO:0035150 None ADORA1, ADRA2A, CHRM1, CHRM3, EGFR, HMGCR, PTAFR, PTGS2, SLC6A4 5.39106
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGES, PTGS1, PTGS2 5.33757
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, GRM1, HMGCR, HSPA1A, MMP2, PPARA, PTAFR, PTGS2, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 5.31231
[BP] GO:0007187 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.30294
[BP] GO:0006940 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, PTAFR, PTGS2 5.24648
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.24648
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, APP, AURKB, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.24458
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PIK3CB, PTPN1, SRC 5.23179
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PTGS2, RORC, SRC, TEK 5.21929
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.19347
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3 5.17191
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, PTPN1, SRC 5.11894
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.05451
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, PTAFR, PTGS2, RELA, SLC6A4, SMAD3, SRC 5.03364
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.01787
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.9979
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, MAOA, PTGS2, SLC1A1, SLC6A2, SLC6A4, SMAD3 4.98752
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 4.97365
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, RORC, SMAD3, SRC, TEK, TYR 4.97338
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 4.97064
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CHRM1, CYP19A1, EGFR, HCAR2, INSR, KCNH2, MIF, MMP12, PTAFR, PTGS2, SLC6A4, SMAD3, SRC, TERT 4.95914
[BP] GO:0023052 None ADORA1, AR, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, KCNH2, SLC1A1, SLC6A2, TEK 4.92235
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, AR, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 4.91943
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTAFR, PTGES, PTGS2, RELA, SLC6A4, SRC 4.91892
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS2, PTPN1, SRC, TEK, XDH 4.86484
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 4.81457
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.81457
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, CACNA1C, EGFR, HCAR2, HMGCR, KDR, MIF, PIK3CB, PTGS2, SRC 4.76644
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KCNH2, KDR, MAP2K1, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.743
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, HMGCR, KDR, MAP2K1, MIF, PTPN1, SRC, TEK 4.71574
[BP] GO:0006693 None CES2, MIF, PTGES, PTGS1, PTGS2 4.66447
[BP] GO:0006692 None CES2, MIF, PTGES, PTGS1, PTGS2 4.66447
[BP] GO:0019371 None CBR1, PTGES, PTGS1, PTGS2 4.63941
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, GRM1, INSR, MAP2K1, MAP3K7, MIF, PIK3CB, PTPN1, SRC 4.55019
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTAFR, PTGS2, RORC, SLC6A4, SRC 4.55019
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR, HMGCR 4.53875
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.53209
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.51905
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS2, PTPN1, SRC, TEK, XDH 4.47877
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 4.47263
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.47263
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.47263
[BP] GO:0007200 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 4.47263
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, PTGS2, RELA, SLC6A4, SRC, TEK, TYR 4.45424
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGES, PTGS1, PTGS2 4.44407
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 4.44405
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.43204
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 4.41619
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.38823
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.38823
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, HMGCR, HSD17B3, MIF, PTAFR, PTGES, PTGS1, PTGS2 4.38724
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KCNH2, KDR, MAP2K1, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.35832
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 4.35832
[BP] GO:0001516 None MIF, PTGES, PTGS1, PTGS2 4.35832
[BP] GO:0046457 None MIF, PTGES, PTGS1, PTGS2 4.35832
[BP] GO:0007154 None ADORA1, AR, AXL, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1, SLC6A2, TEK 4.35832
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 4.33816
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 4.33072
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, MAP2K1, PIK3CA, RELA, SMAD3, TYR 4.32505
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 4.31473
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MAP2K1, MET, MIF, MMP12, PPARA, PTGS2, RELA, SMAD3, TEK 4.3104
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, CA2, CA7, CACNA1C, CHRM1, GPR35, GRM5, KCNH2, MIF, MMP9, PTAFR, PTGS2, SLC6A4 4.30462
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR, HSPA1A, MAOA 4.29151
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.23262
[BP] GO:0019229 None ADRA2A, CHRM1, CHRM3, EGFR, PTAFR, PTGS2 4.22939
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, EGFR, GRM1, INSR, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 4.21325
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 4.18041
[BP] GO:0007267 None ADORA1, AR, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 4.16172
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AR, AURKB, CSNK2A1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TERT, XDH 4.15685
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGES, PTGS2, TERT 4.15283
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, HMGCR, KDR, MAP2K1, MIF, SRC, TEK 4.13064
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, PTAFR, PTGS2, RELA, SLC6A4, SRC 4.089
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 4.08824
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MAP2K1, MAP3K7, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 4.06789
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, PTGS2, RELA, SLC6A4, SRC, TEK, TYR 4.05864
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, KCNH2, KDR, PTAFR, PTGS2, RELA, SLC6A2, SLC6A4, SRC 4.00592
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.00592
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.00592
[BP] GO:0070920 None EGFR, ESR1, MAP2K1, TERT 4.00592
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MIF, NUAK1, PTGS2, PTPN1, TERT, XDH 3.99046
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 3.98377
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 3.94315
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 3.91917
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.9113
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, HSPA1A, MIF, MMP9, PTGS2, PTPN1, RELA, SRC, TERT 3.9113
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.88544
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, RELA, SRC 3.88045
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 3.87705
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 3.85192
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 3.83688
[BP] GO:0006937 None ADORA1, ADRA2A, CACNA1C, CHRM1, CHRM2, CHRM3, PTAFR, PTGS2 3.82074
[BP] GO:0003008 None ADORA1, ADRA2A, AKR1B1, APP, CHRM1, CHRM3, CHRM5, CYP1B1, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, KCNH2, PIK3CA, PTAFR, PTGS2, SLC6A4, SRC, TEK, TYR 3.81702
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, PTGS2, RELA, SRC, TEK 3.81702
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CES1, CYP19A1, HMGCR, HSD17B3, PTAFR, TYR 3.80688
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KCNH2, KDR, PTAFR, PTGS2, RELA, SRC 3.79744
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 3.78229
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, PTAFR, PTGS2, RELA, SLC6A4, SRC 3.77427
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA2A, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, PIK3CA, PIK3CB, PTAFR, SRC 3.75425
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, RELA, SMAD3, SRC, TERT, XDH 3.72583
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.71743
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, MIF, PIK3CA, PIK3CB, PTAFR, PTGES, PTGS1, PTGS2, RELA 3.70769
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, CACNA1C, CYP1B1, EGFR, GRM5, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, NUAK1, PIK3CA, PIK3CB, PTAFR, PTPN1, RELA, SRC, TEK 3.70258
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 3.69808
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.69808
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.69765
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 3.69224
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MAP3K7, MMP12, MMP2, PPARA, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK 3.67845
[BP] GO:0090257 None ADORA1, ADRA2A, CACNA1C, CHRM1, CHRM2, CHRM3, PTAFR, PTGS2, SMAD3 3.6745
[BP] GO:0050730 None ADORA1, ADRA2A, APP, EGFR, FLT3, GRM5, MIF, PTPN1, SRC 3.63245
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, SLC6A4, SRC, TERT 3.59335
[BP] GO:1901570 None ALOX15, ALOX5, MIF, PTGES, PTGS1, PTGS2 3.57411
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.55994
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, PTAFR, RELA, SRC 3.53521
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HMGCR, HSD17B1, HSD17B2, HSD17B3 3.52626
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, CACNA1C, CHRM1, EGFR, HCAR2, HMGCR, MIF, MMP12, PTGS2, PTPN1, SMAD3, SRC 3.52073
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF, PTAFR 3.51853
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.50738
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PPARA, PTPN1, RELA, SMAD3 3.50147
[BP] GO:0046683 response to organophosphorus APP, PTAFR, PTGS2, RELA, SLC6A4, TEK, TYR 3.44341
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.40841
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.40841
[BP] GO:0001819 positive regulation of cytokine production ADRA2A, CYP1B1, HSPA1A, MAP3K7, MIF, MMP12, PTAFR, PTGS2, RELA, SMAD3, SRC 3.35429
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.33707
[BP] GO:0042391 None ADORA1, APP, CACNA1C, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC 3.30822
[BP] GO:0010676 None ESRRB, INSR, PPARA, PTAFR, SRC 3.30409
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, XDH 3.29185
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 3.28647
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 3.21903
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, EGFR, HCAR2, MET, PIK3CA, PPARA, RELA, SMAD3 3.21526
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.20721
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, CA2, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, MAP3K7, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PTAFR, PTPN1, RELA, SMAD3, SRC 3.20686
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 3.18035
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 3.14618
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.14464
[BP] GO:0014074 response to purine-containing compound APP, PTAFR, PTGS2, RELA, SLC6A4, TEK, TYR 3.14464
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CACNA1C, CYP19A1, EGFR, GRIK5, HCAR2, HMGCR, MIF, MMP12, PTAFR, SLC6A4, SRC 3.13692
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, MAP2K1, SRC 3.13583
[BP] GO:0050890 None ADORA1, APP, CHRM1, EGFR, GRM5, HMGCR, INSR, PTGS2, SLC6A4 3.11389
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.11389
[BP] GO:0008217 None ADORA1, AR, PPARA, PTAFR, PTGS1, PTGS2, SMAD3 3.09611
[BP] GO:0003006 developmental process involved in reproduction AR, AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, MAP2K1, PTGS2, SRC 3.07184
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, XDH 3.06883
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, HSPA1A, MAP2K1, PTGES, PTGS2, SLC6A4, SMAD3, TERT, XDH 3.00134
[BP] GO:0071396 cellular response to lipid AR, AXL, EGFR, ESR1, FLT3, PTAFR, RELA, RORC, SLC6A4, SRC 2.99604
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2, HSD17B3 2.99604
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.976
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.94337
[BP] GO:0022414 reproductive process AKR1B1, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, MAP2K1, MMP2, MMP9, PTAFR, PTGS2, SLC6A4, SRC 2.94301
[BP] GO:0048545 response to steroid hormone AR, CA2, EGFR, FLT3, PTAFR, PTGS2, RELA, SRC 2.94301
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.91178
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, APP, AR, CACNA1C, CHRM1, CSNK2A1, EGFR, HCAR2, HMGCR, MIF, MMP12, PTGS2, PTPN1, SMAD3, SRC, TERT 2.89942
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.88067
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.87968
[BP] GO:0090066 None ADORA1, ADRA2A, ALOX15, CHRM1, CHRM3, EGFR, HMGCR, PTAFR, PTGS2, SLC6A4 2.87968
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, APP, AR, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TYR, XDH 2.84967
[BP] GO:1902893 None PPARA, RELA, SMAD3, TERT 2.82641
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.82641
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CACNA1C, CYP19A1, EGFR, GRIK5, HCAR2, HMGCR, MIF, MMP12, PTAFR, SLC6A4, SRC 2.82001
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APP, AR, AURKB, CSNK2A1, CYP2D6, DUSP3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TERT, XDH 2.81369
[BP] GO:0009115 None AOX1, XDH 2.8017
[BP] GO:0007568 aging AURKB, CYP1A1, HMGCR, MAP2K1, MIF, PTGS2, RELA, TERT 2.79862
[BP] GO:0045913 None ESRRB, INSR, PPARA, PTAFR, SRC 2.79544
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 2.79474
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2C19, CYP2D6, MAOA 2.78259
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, HSPA1A, MIF, MMP9, PTGS2, PTPN1, RELA, SMAD3, SRC, TERT 2.78028
[BP] GO:0015872 None CHRM5, SLC6A2, SLC6A4 2.77805
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MIF, MMP12, PTAFR, SLC6A4, SRC 2.7741
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, HSD17B3 2.77389
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.74318
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, GRM5, MIF, PTPN1, SRC 2.72822
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, MAP3K7, PIM1, RELA 2.7236
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, RELA, SMAD3, TEK 2.7236
[BP] GO:0001775 cell activation ADRA2A, ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, RORC, SMAD3, SRC 2.72309
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 2.71677
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, SLC1A1, SLC6A2, SLC6A4 2.69658
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.69658
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC, TEK 2.69658
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.69658
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.6817
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.65934
[BP] GO:0010675 None ESRRB, INSR, PPARA, PTAFR, RORC, SRC 2.65934
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 2.64836
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, PTAFR, PTGS2, RELA, RORC, SMAD3, SRC, TERT 2.64696
[BP] GO:0061097 None ADORA1, ADRA2A, APP, GRM5, PTPN1 2.64672
[BP] GO:0030155 regulation of cell adhesion ALOX15, CYP1B1, DUSP3, KDR, MAP3K7, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, SMAD3, SRC, TEK 2.6409
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 2.62594
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.62349
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CES1, CYP1A1, CYP1B1, HMGCR, KDR, RELA, SLC6A4, SRC 2.61489
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2, SLC6A4 2.61056
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.594
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.59317
[BP] GO:0097756 None ADORA1, HMGCR, PTGS2, SLC6A4 2.58362
[BP] GO:0060341 regulation of cellular localization ADRA2A, APP, AR, CACNA1C, CHRM1, CSNK2A1, EGFR, GRIK5, HMGCR, MAP2K1, PTGS2, PTPN1, SMAD3, SRC, TERT 2.58343
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.57639
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, XDH 2.57427
[BP] GO:0051223 None ACHE, ADRA2A, APP, CACNA1C, CHRM1, EGFR, HCAR2, HMGCR, MIF, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.56653
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, HMGCR, INSR, KDR, MAP2K1, MIF, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.56008
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.51798
[BP] GO:1903798 None EGFR, ESR1, MAP2K1 2.50944
[BP] GO:0051937 None CHRM5, SLC6A2, SLC6A4 2.50944
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.50944
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.50944
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.50944
[BP] GO:0051172 None ADRA2A, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TERT, XDH 2.49485
[BP] GO:1901224 None APP, EGFR, MAP3K7, RELA 2.4722
[BP] GO:0007584 response to nutrient CYP1A1, EGFR, HMGCR, PTGS2, RELA, SLC6A4, TYR 2.4722
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF, PIK3CB 2.46288
[BP] GO:0033273 response to vitamin CYP1A1, EGFR, PTGS2, RELA, TYR 2.46288
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.43638
[BP] GO:0061098 None ADORA1, ADRA2A, GRM5, PTPN1 2.43638
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.43638
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.43638
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, MAP2K1, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTAFR, SRC, TEK 2.43406
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TERT 2.43262
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, CA2, CYP1B1, ESRRB, F3, HMGCR, INSR, KDR, MAP2K1, PIM1, PTGS2, RELA, SMAD3, SRC, TEK, TERT 2.40701
[BP] GO:0099566 None GRM1, GRM5 2.40701
[BP] GO:0033590 None EGFR, RELA 2.40701
[BP] GO:0046110 None AOX1, XDH 2.40701
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.40701
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.40701
[BP] GO:0002520 None CACNA1C, SMAD3 2.40701
[BP] GO:0051234 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM3, CHRM5, EGFR, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KCNH2, MIF, MMP12, MMP9, PPARA, PTAFR, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, XDH 2.4043
[BP] GO:0006633 None ALOX15, MIF, PTGES, PTGS1, PTGS2 2.38602
[BP] GO:0042058 None ADORA1, ADRA2A, APP, EGFR, MMP9 2.38602
[BP] GO:0001817 regulation of cytokine production ADRA2A, AXL, CYP1B1, HSPA1A, MAP3K7, MIF, MMP12, PTAFR, PTGS2, RELA, SMAD3, SRC 2.384
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A4 2.37358
[BP] GO:0070201 None ACHE, ADRA2A, APP, CACNA1C, CHRM1, EGFR, HCAR2, HMGCR, MIF, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.36478
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, GPR35, KCNH2, MMP9, PTGS2 2.34905
[BP] GO:0006066 None AKR1B1, AKR1B10, ALDH2, APP, CES1, CYP1B1, HMGCR, PTAFR 2.34369
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.3397
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.3397
[BP] GO:1903532 None ACHE, CYP19A1, EGFR, HCAR2, MIF, MMP12, PTAFR, SLC6A4, SRC 2.3341
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.32843
[BP] GO:0055080 cation homeostasis APP, CA2, CA7, CACNA1C, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 2.32787
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, MIF, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TERT 2.32669
[BP] GO:0000187 activation of MAPK activity GRM1, INSR, MAP2K1, MAP3K7, PIK3CB, PTPN1 2.32391
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, KDR, MET, MIF, PTGS2, SMAD3 2.3188
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, PTAFR, RELA, RORC, SMAD3, SRC, TERT 2.31116
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 2.31116
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, HSPA1A, INSR, KDR, MAP3K7, PIK3CB, PPARA, PTPN1 2.31116
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, IGF1R, INSR, RELA, SRC 2.31116
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.31116
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.31116
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.29325
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC 2.27392
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, CACNA1C, EGFR, HCAR2, HMGCR, MIF, MMP12, SRC 2.26187
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 2.25643
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX15, CYP1A1, MIF, PTGES, PTGS1, PTGS2 2.25395
[BP] GO:0051591 None APP, PTAFR, RELA, TEK, TYR 2.18881
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.18881
[BP] GO:0055082 cellular chemical homeostasis APP, CA2, CA7, CACNA1C, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, SMAD3 2.18881
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.18502
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PTGS2, TEK, TERT 2.16858
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.16618
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.16618
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3, TERT 2.16093
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, PTAFR, PTGS2, RELA, RORC, SMAD3, SRC, TERT 2.15937
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.15937
[BP] GO:0006145 None AOX1, XDH 2.15937
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.15937
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.15937
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, EGFR, MIF, PIK3CA, PTGS2 2.14799
[BP] GO:1901184 None ADORA1, ADRA2A, APP, EGFR, MMP9 2.14799
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.14003
[BP] GO:0015844 None CHRM5, SLC6A2, SLC6A4 2.14003
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.13008
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 2.12941
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, SRC, TEK 2.12941
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, PIK3CB, PTGS2 2.1262
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.12574
[BP] GO:0000186 activation of MAPKK activity ADORA1, EGFR, GRM1, MAP3K7 2.12574
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.12574
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.11833
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.11833
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.11833
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.11833
[BP] GO:1902895 None RELA, SMAD3, TERT 2.09076
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.09076
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.09076
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.09076
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, CHRM1, EGFR, HCAR2, MIF, MMP12, PTGS2, SMAD3, SRC 2.08677
[BP] GO:0001952 regulation of cell-matrix adhesion KDR, PIK3CB, SMAD3, SRC, TEK 2.08431
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, HSPA1A, RELA, SRC, TERT 2.08431
[BP] GO:2000243 None AR, INSR, PTAFR, SRC 2.07596
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.07596
[BP] GO:0050877 None ADORA1, APP, CHRM1, CHRM5, CYP1B1, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, PTGS2, SLC6A4, TYR 2.06962
[BP] GO:0060627 regulation of vesicle-mediated transport ADRA2A, ALOX15, APP, AXL, GRIK5, MAP2K1, PIK3CB, PTAFR, PTPN1, SRC 2.06367
[BP] GO:0031331 positive regulation of cellular catabolic process ADRA2A, ESRRB, HSPA1A, INSR, KDR, MAP3K7, PIK3CB, PPARA, PTPN1 2.06052
[BP] GO:0001889 liver development CSNK2A1, EGFR, PIK3CA, RELA, SMAD3 2.05188
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.05185
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.05185
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.04403
[BP] GO:0007611 None APP, EGFR, GRM5, HMGCR, INSR, PTGS2, SLC6A4 2.04403
[BP] GO:0051179 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM3, CHRM5, EGFR, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KCNH2, MIF, MMP12, MMP9, PPARA, PTAFR, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, XDH 2.04247
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.03522
[BP] GO:0043270 None ADORA1, ADRA2A, CHRM1, KCNH2, MIF, PTAFR, SLC6A4 2.01368
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA, SRC 2.00216
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTPN1, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 7.64632
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KCNH2, KDR, MET, PTAFR, PTGS2, SLC1A1, SLC6A2, SLC6A4, SRC, TEK 6.98845
[CC] GO:0098590 plasma membrane region ADORA1, ADRA2A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, PTGS2, SLC1A1, SRC, TEK 6.73729
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, TEK 6.70592
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HSD17B3, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 5.9141
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, TEK 5.31963
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HSD17B3, IGF1R, INSR, KCNH2, KDR, MAOA, MET, PIK3CA, PIK3CB, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TEK, TYR 5.07012
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4, SRC 4.94442
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 4.53328
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC6A2, SLC6A4, SRC 3.64002
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, CHRM3, EGFR, TEK 3.40841
[CC] GO:0005783 None ADORA1, APP, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GRIK5, HMGCR, HSD17B3, HSPA1A, KDR, MAP2K1, PTGS2, PTPN1, XDH 3.34442
[CC] GO:0043235 receptor complex ADRA2A, APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.33707
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.29393
[CC] GO:0014069 None ADORA1, CACNA1C, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 3.22464
[CC] GO:0099572 None ADORA1, CACNA1C, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 3.22464
[CC] GO:0044432 endoplasmic reticulum part APP, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR, F10, FLT3, GRIA2, HMGCR, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, PTPN1 3.22464
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 3.0484
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 2.96508
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MIF, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, SLC6A4, SMAD3, SRC, TERT, TYR, XDH 2.90217
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.88067
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.86106
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, GRIK5, SLC6A4 2.82215
[CC] GO:0097458 None ADORA1, APP, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, PTGS1, PTGS2, SLC6A2, SLC6A4, SRC 2.77805
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.67401
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2 2.49155
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.40105
[CC] GO:0098589 membrane region APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.34884
[CC] GO:0009986 cell surface ACHE, APP, AXL, CA4, EGFR, F3, KCNH2, MET, MIF, SLC6A2, TEK 2.27471
[CC] GO:0031233 None CA4, F10, F3 2.18502
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 13.6629
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, F10, F3, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, SRC, TEK, TERT, TYR, XDH 11.6453
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.2779
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, TEK 11.1696
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 11.0592
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, PPARA, PTAFR, RORC, SMAD3, TEK 10.8706
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, TEK 9.92578
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, TEK 9.58173
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HMGCR, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 8.88346
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.59037
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SRC, TEK 6.98845
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.98845
[MF] GO:0042562 hormone binding ACHE, AR, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NQO2, SHBG 6.86566
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PTAFR, TEK 6.78218
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PTAFR, TEK 6.78218
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3 6.70592
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.64397
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.20205
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HMGCR, HSD17B1, NQO2, PTGES, PTGS1, PTGS2, SRC, XDH 6.18188
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.0562
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 6.04258
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.00983
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.00983
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 5.96642
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.9141
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, XDH 5.79756
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC, SHBG 5.6598
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 5.51398
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.5033
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.33753
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD17B1, HSD17B2, HSD17B3, XDH 5.3175
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 5.28182
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 5.27292
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 5.23917
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.92477
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.91943
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2, TYR 4.90015
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 4.89125
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, CSNK2A1, EGFR, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KCNH2, KDR, MAP3K7, MET, MIF, MMP9, NQO2, PTGS2, RELA, SLC6A4, SMAD3, TERT, TYR, XDH 4.78362
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.66447
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.63941
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, PPARA, PTAFR, RORC, SHBG 4.43083
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.42899
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TYR 4.25432
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SLC6A4, SMAD3, SRC 4.2414
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SLC6A4, SMAD3, SRC 4.22945
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT 4.089
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, HSPA1A, KCNH2, MET, MIF, PPARA, PTAFR, PTGS2, PTPN1, RELA, SLC6A4, SMAD3, SRC, TEK 4.00581
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.91917
[MF] GO:0043168 anion binding ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTAFR, PTGES, RELA, SLC1A1, SRC, TEK, XDH 3.90157
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.81291
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, HSD17B3 3.67845
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 3.63897
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 3.43879
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.13824
[MF] GO:0008227 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5 3.12992
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 2.976
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.8017
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.8017
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP2D6 2.78567
[MF] GO:0036094 small molecule binding ADORA1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SLC1A1, SRC, TEK, XDH 2.75073
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, MAP2K1, MAP3K7, SMAD3 2.64366
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.62349
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, FLT3, HMGCR, KCNH2, NQO2, PTGS2, RELA, SLC6A4, SMAD3, TERT, TYR, XDH 2.50944
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 2.48443
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AR, AXL, EGFR, FLT3, HMGCR, KCNH2, NQO2, PTGS2, RELA, SLC6A4, SMAD3, TERT, TYR, XDH 2.42307
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.40701
[MF] GO:0005330 None SLC6A2, SLC6A4 2.40701
[MF] GO:0099583 None GRM1, GRM5 2.40701
[MF] GO:0047374 None CES1, CES2 2.40701
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.24758
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.24758
[MF] GO:0016788 None ACHE, ADORA1, CA1, CA2, CDC25B, CES1, CES2, CHRM1, CHRM3, CHRM5, DUSP3, MAP2K1, PTPN1 2.19603
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.18502
[MF] GO:0000166 nucleotide binding ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 2.16312
[MF] GO:1901265 nucleoside phosphate binding ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 2.16118
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, PTAFR, PTPN1, RELA, SMAD3, SRC 2.16093
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.15937
[MF] GO:0004971 None GRIA2, GRIA4 2.15937
[MF] GO:0032795 None ADORA1, ADRA2A 2.15937
[MF] GO:0005497 None AR, SHBG 2.15937
[MF] GO:0051425 None APP, INSR 2.15937
[MF] GO:0004930 None ADORA1, ADORA3, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, PTAFR 2.15847
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, SRC, TEK 2.15611
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, GRM5, PTAFR, PTPN1, RELA, SMAD3, SRC 2.07971
[MF] GO:0019902 phosphatase binding EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 2.06052
[MF] GO:0047485 None CSNK2A1, HSPA1A, MAP2K1, RELA, TERT 2.03756


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GPR35, GRIK5, CHRM5, PTAFR, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 10.2615
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.8579
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 9.8579
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 11.8748
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, CYP2D6, ALOX5, ALOX15, CACNA1C, PTGS2, CYP2C19, PTGS1, SLC6A4 9.4285
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, MAP2K1, CHRM1, PIK3CA, ADORA1, CACNA1C, PIK3CB, PPARA, RELA, GRIA4 8.0389
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MAP3K7, MET, EGFR, IGF1R 8.4323
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, MAP2K1, CHRM1, PIK3CA, CHRM5, CACNA1C, PIK3CB 6.963
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 6.95
Pathways in cancer_Homo sapiens_hsa05200 MAP2K1, SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, RELA, IGF1R, AR, PIK3CA, MET 6.7129
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 6.95
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, HSD17B3, AKR1B1, HMGCR, PTGS2, TYR, CYP2C19, CYP19A1, PTGS1, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, PTGES, CES1 6.3635
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.7129
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, CYP2C19, PTGES, PTGS1 6.4639
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, MAP2K1, PIK3CA, INSR, GRM8, PIK3CB, GRM1, EGFR 6.2928
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, CHRM1, PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, RELA, IGF1R 5.9201
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 6.015
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 6.6383
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, PIK3CA, INSR, TEK, PIK3CB, EGFR, RELA, IGF1R 6.2928
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, RELA, IGF1R 5.759
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, ESR2, RELA 6.16
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, PTAFR, CACNA1C, GRM1, EGFR 5.6174
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, PIK3CA, PIK3CB, EGFR, RELA, IGF1R 5.6171
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 6.2928
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, PIM1, PIK3CB, F3, RELA 5.3054
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 5.5899
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9, EGFR 6.2716
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, MAP2K1, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB, EGFR 5.1124
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, PIM1, PIK3CB, RELA 5.5453
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.1102
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.3834
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, INSR, ADORA1, CACNA1C, PIK3CB, ADRA2A 4.9694
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, SMAD3, PIK3CA, PIK3CB, EGFR, RELA 5.2082
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, MET, EGFR, IGF1R 4.3815
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, PIK3CB, MET, EGFR 5.1835
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SMAD3, PIK3CA, SRC, PIK3CB, MMP9, RELA 4.3532
Melanoma_Homo sapiens_hsa05218 MAP2K1, PIK3CA, PIK3CB, MET, EGFR, IGF1R 5.0738
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2, EGFR 4.1516
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.0909
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, PTGS2, GRM1, GRIA4 4.2388
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA, RELA 4.0909
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 4.7296
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, DUSP3, CACNA1C, MAP3K7, EGFR, RELA, CDC25B, HSPA1A 3.8094
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB, MAP3K7, RELA, HSPA1A 3.9439
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, PIK3CA, ADORA3, ADORA1, PIK3CB, RELA 3.9115
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.0932
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA, HSPA1A 3.6488
Glioma_Homo sapiens_hsa05214 MAP2K1, PIK3CA, PIK3CB, EGFR, IGF1R 4.0909
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, HMGCR, MAP3K7, IGF1R 3.857
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 3.5667
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, MAP2K1, CACNA1C, GRM1 4.0681
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, SMAD3, PIK3CA, PIK3CB, RELA 3.909
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, PIK3CA, SRC, PIK3CB, EGFR 3.5748
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP2D6, CYP1A2, AOX1, CYP2C19 3.9834
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C, EGFR 3.5049
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.0532
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PIK3CB, CDC25B, IGF1R 3.3883
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, RELA, IGF1R 3.4599
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.909
Gap junction_Homo sapiens_hsa04540 GRM5, MAP2K1, SRC, GRM1, EGFR 3.5667
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.2771
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.2483
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA, HSPA1A 2.8821
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1 3.0572
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 2.8821
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2064
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR, RELA 2.8768
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA, RELA 2.6588
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2286
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2374
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1, PIK3CA, INSR, PIK3CB 2.8005
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2633
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3005
Influenza A_Homo sapiens_hsa05164 MAP2K1, PIK3CA, PIK3CB, RELA, HSPA1A 2.4002
Axon guidance_Homo sapiens_hsa04360 MET 0.3147
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.3516
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PIK3CA, SRC, PIK3CB, RELA 2.2845
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3865
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4047
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.5812
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.5812
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, PIK3CB, RELA 1.9952
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6094
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4171
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PIK3CA, PIK3CB, RELA 2.1982
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, PIK3CA, PIK3CB, EGFR 2.4421
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4186
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB, RELA 1.7721
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4186
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.1859
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4186
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB, RELA 2.4003
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4282
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4224
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, AOX1, PIK3CB 1.833
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4186
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4186
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7249
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.2198
Peroxisome_Homo sapiens_hsa04146 XDH 0.4299
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, CACNA1C, GRIA4 2.1037
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB, RELA 1.4957
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1921
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4337
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.0406
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4299
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PIK3CA, PIK3CB, RELA 2.9069
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7875
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4445
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4466
Pertussis_Homo sapiens_hsa05133 RELA 0.4536
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, CACNA1C, PIK3CB 1.2445
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.7991
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, MAP3K7 1.2828
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2, MAP3K7, RELA 2.5646
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1, PIK3CA, PIK3CB 1.3282
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4558
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.4178
Long-term depression_Homo sapiens_hsa04730 GRIA2, MAP2K1, GRM1, IGF1R 3.1738
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2, RELA 2.6761
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.0454
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, CACNA1C, GRIA4 3.0263
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 0.9252
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8199
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, PIK3CA, PIK3CB, EGFR 3.3883
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.937
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, PIK3CA, PIK3CB, EGFR 3.2771
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.9492
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, SMAD3, PIK3CA, PIK3CB 3.1315
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.6558
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.4893
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5036
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1, PIK3CA, PIK3CB 1.7093
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR, RELA 3.0075
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9944
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, RELA 1.6398
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.6882
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9889
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0082
Insulin secretion_Homo sapiens_hsa04911 CHRM3, CACNA1C 1.0313
Taste transduction_Homo sapiens_hsa04742 CHRM3, CACNA1C, GRM1 1.8283
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5508
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, CACNA1C, PIK3CB 3.4977
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0808
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA, RELA 3.4697
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.1279
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.5763
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.1614
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 1.9658
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PIK3CB 2.0392
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5812
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.1568
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1568
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.1614
Malaria_Homo sapiens_hsa05144 MET 0.5885
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6019
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.2185
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2096
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.2627
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.0899
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC, RELA 2.0899
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF, TYR 3.9473
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.2967
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6221
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.1912
Legionellosis_Homo sapiens_hsa05134 RELA, HSPA1A 1.3218
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6566
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.6566
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2, MAOA 1.388
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.4175
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7683
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.4628
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7496
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.4593
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.7496
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.6588
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7683
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5521
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7981
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7572
Prion diseases_Homo sapiens_hsa05020 MAP2K1, HSPA1A 1.6552
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7886
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.7886
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.765
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1, EGFR 1.838
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7147
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP2C19 2.9876
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.7457
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8604
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9658
Histidine metabolism_Homo sapiens_hsa00340 ALDH2, MAOA 1.934
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.1912
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3339
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1554


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)