TCM Prescription: He Wei Tablets



Prescription Description
Prescription IDTCMF4342
Pinyin NameHe Wei Pian
Chinese Name和胃片
English NameHe Wei Tablets
Function Description胃脘痛, 腹胀, 呕吐
IndicationsStomach ache disorder, Enteritis, Dyspepsia
Disease ICD-11 Category SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1) ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
MD92 [Dyspepsia, 消化不良 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH2431 Datura metel 洋金花 TCMH2431 ITSAM3639-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2156 Concha arcae 瓦楞子 TCMH2156
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ABCB1, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 11.3419
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 11.2783
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KCNH2, KDR, MAOA, MET, PPARA, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.0533
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 11.0468
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, PTGES, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 10.2614
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SLC6A4, SRC, TEK, TYR 10.2614
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MET, PPARA, PTGES 10.131
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 10.1301
[BP] GO:0042127 regulation of cell proliferation ADRA2A, AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.89532
[BP] GO:0010647 positive regulation of cell communication ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.83571
[BP] GO:0023056 positive regulation of signaling ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.8125
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CDK6, CES1, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR 9.62404
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTGES, RELA, RORC, SLC6A4, SRC, TYR 9.26509
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTGES, RELA, RORC, SLC6A4, SRC, TEK, TYR 9.22782
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, PPARA, RELA, SLC6A4, SRC, TEK 9.15529
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, RELA, SLC6A4, SMAD3, SRC, TEK 9.10597
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, PPARA, PTPRS, RELA, SMAD3, SRC, TEK, TYR 8.90477
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FDPS, FUT7, GBA2, GLO1, HSD17B3, HSPA1A, PIM1, PPARA, PTGES, TYR, XDH 8.75226
[BP] GO:0009967 positive regulation of signal transduction ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.68869
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 8.2991
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, RELA, RORC, SLC6A4, SMAD3, SRC, TERT 8.17453
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGES, RELA, SRC, TERT 8.17453
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 7.801
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.78718
[BP] GO:0032501 multicellular organismal process ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TNKS2, TYR 7.71332
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, TEK, XDH 7.66678
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.61878
[BP] GO:0010646 regulation of cell communication ACHE, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PTPN1, PTPRS, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.48427
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.42031
[BP] GO:0023051 regulation of signaling ACHE, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PTPN1, PTPRS, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.33148
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MMP2, MMP9, NUAK1, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A 7.16237
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR 7.14649
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, MMP9, PIM1, PPARA, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TYR 7.0158
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, RELA, TEK, TERT 6.99975
[BP] GO:0048584 positive regulation of response to stimulus ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.94536
[BP] GO:1902531 regulation of intracellular signal transduction ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PTPN1, RELA, SRC, TEK, XDH 6.94536
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 6.7688
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.75334
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.70942
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RELA, RORC, SLC6A4, SMAD3, SRC 6.69206
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADRA2A, ALOX15, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 6.66209
[BP] GO:0080134 regulation of response to stress ABCB1, ADRA2A, APP, CDK6, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, PTPRS, RELA, SMAD3, SRC, TEK, TERT, XDH 6.46357
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 6.46255
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGES 6.40048
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 6.26601
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.23657
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MAP2K1, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.23356
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGES 6.16522
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MAP2K1, MET, PIM1, SRC, TEK, TYR 6.10658
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.0567
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TNKS 5.9472
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.9472
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 5.85986
[BP] GO:0060548 negative regulation of cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TERT 5.85986
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.8256
[BP] GO:0051239 regulation of multicellular organismal process ADRA2A, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HSPA1A, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, PTPRS, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH 5.79409
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK, TERT 5.7937
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.7937
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FABP3, FABP4, FDPS, FUT7, GBA2, MET, PPARA, PTGES 5.7874
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, PTPRS, RELA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.73879
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGES 5.68044
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.67138
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.66076
[BP] GO:0040012 regulation of locomotion ADRA2A, APEX1, APP, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.65266
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 5.64601
[BP] GO:0051270 regulation of cellular component movement ADRA2A, APEX1, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.63849
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 5.62729
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.57263
[BP] GO:0009966 regulation of signal transduction ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PTPN1, PTPRS, RELA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.53367
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, FDPS, GBA2, HSD17B3, MAOA, TYR 5.50685
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.49839
[BP] GO:2000145 regulation of cell motility ADRA2A, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.48663
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, KCNH2, KDR, RELA, SLC6A2, SLC6A4, SRC 5.47514
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3, TERT, TNKS, TOP2A 5.39859
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.38555
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA, PTGES 5.33257
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.27903
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK, TERT 5.26757
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.22159
[BP] GO:0048523 negative regulation of cellular process ACHE, ADRA2A, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KCNH2, KDR, MAP2K1, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.20278
[BP] GO:0030334 regulation of cell migration ADRA2A, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.20171
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRA2A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.15401
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRA2A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.09936
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.09269
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 4.95978
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 4.95978
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGES 4.89068
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GBA2, GLO1, PPARA, PTGES 4.81367
[BP] GO:0009893 positive regulation of metabolic process ADRA2A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.75527
[BP] GO:0031325 positive regulation of cellular metabolic process ADRA2A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.70791
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.6931
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CDK6, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, RELA, RORC, SLC6A4, SRC 4.6481
[BP] GO:0048585 negative regulation of response to stimulus ADRA2A, ALOX15, AR, BCL2, CDK6, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, PTPRS, RELA, SMAD3, SRC, TEK, TERT, XDH 4.64744
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TNKS 4.64626
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, RORC, SLC6A4, SRC 4.61847
[BP] GO:0019220 regulation of phosphate metabolic process ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, CHRM5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.59679
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADRA2A, APP, AR, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.56584
[BP] GO:0010817 regulation of hormone levels ACHE, ADRA2A, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.54562
[BP] GO:0051174 regulation of phosphorus metabolic process ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, CHRM5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.54195
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRA2A, AR, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SLC6A4, SMAD3, SRC, TERT, XDH 4.54141
[BP] GO:0043410 positive regulation of MAPK cascade ADRA2A, ALOX15, APP, AR, EGFR, FLT3, INSR, KDR, MAP2K1, MAP3K7, PTPN1, SRC, TEK, XDH 4.5351
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, RELA, SRC 4.53265
[BP] GO:0023057 negative regulation of signaling ACHE, ADRA2A, AR, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SLC6A4, SMAD3, SRC, TERT, XDH 4.52813
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, APP, AR, AXL, BCL2, CA2, CHRM3, CYP1B1, EGFR, ESRRB, F3, HSPA1A, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, RELA, SMAD3, SRC, TEK, TERT 4.44362
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.42651
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.36184
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.36184
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, MAP2K1, RELA, SMAD3, TYR 4.35678
[BP] GO:0043408 regulation of MAPK cascade ADRA2A, ALOX15, APP, AR, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, PTPN1, SRC, TEK, XDH 4.27071
[BP] GO:0048519 negative regulation of biological process ACHE, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KCNH2, KDR, MAP2K1, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.27071
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGES, TERT 4.19186
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, INSR, MAP2K1, MMP2, MMP9, SLC6A4, SRC, TOP2A 4.18692
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 4.1857
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.18407
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PTGES 4.18322
[BP] GO:0042592 homeostatic process ADRA2A, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, KCNH2, MET, SMAD3, SRC, TERT 4.17695
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADRA2A, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CHRM1, CYP19A1, EGFR, GPR35, HSPA1A, INSR, KCNH2, MAP2K1, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TERT 4.12286
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 4.12131
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGES 4.09304
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CYP1A1, CYP1B1, KDR, RELA, SLC6A4, SRC 4.09256
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SLC6A4, SMAD3, SRC, TERT, TNKS, TOP2A 4.01615
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 4.0119
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, ESR1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.99265
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, RELA, SLC6A4, SRC, TEK, TYR 3.98453
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 3.98363
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, MAP2K1, SRC 3.98133
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 3.93218
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.93019
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 3.93019
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FDPS 3.92583
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 3.92583
[BP] GO:0070920 None EGFR, ESR1, MAP2K1, TERT 3.92583
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, RELA, SRC 3.90609
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, APP, AR, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, RELA, SLC6A4, SMAD3, SRC 3.881
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, RELA, SRC, TEK 3.8802
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, SRC, TEK, TNKS, TOP2A 3.8802
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KCNH2, KDR, RELA, SRC 3.84108
[BP] GO:0042327 positive regulation of phosphorylation ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ESRRB, FLT3, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TEK, XDH 3.83428
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, MAP2K1, SRC 3.83428
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, EGFR, FLT3, HSD11B2, RELA, SRC 3.82625
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC, TOP2A 3.82321
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CDK6, CES1, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, KDR, MAP2K1, MET, MMP2, MMP9, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A 3.77784
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.77716
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, RORC 3.77716
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, MMP2, PPARA, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 3.76657
[BP] GO:0009987 cellular process ABCB1, ACHE, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, GPR35, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 3.76657
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 3.74695
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.74006
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.69245
[BP] GO:0007165 signal transduction ADRA2A, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 3.68912
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT 3.66908
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, RELA, SLC6A4, SRC, TEK, TYR 3.62704
[BP] GO:0051247 positive regulation of protein metabolic process ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 3.59837
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.56892
[BP] GO:0042325 regulation of phosphorylation ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.56655
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FDPS 3.54982
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, KCNH2, MET, SMAD3 3.5125
[BP] GO:0001934 positive regulation of protein phosphorylation ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TEK, XDH 3.50234
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.49697
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, EGFR, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, NUAK1, PTPN1, PTPRS, TERT, XDH 3.49251
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.49251
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.49251
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.47087
[BP] GO:0032844 regulation of homeostatic process ADRA2A, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, EGFR, KDR, SRC, TNKS, TNKS2 3.46312
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.4442
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, BCL2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SMAD3, SRC, TERT, XDH 3.42209
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADRA2A, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, INSR, KCNH2, MMP12, SLC6A4, SMAD3, SRC, TERT 3.42209
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, TYR 3.42027
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SLC6A4, SRC 3.41514
[BP] GO:0065009 regulation of molecular function ABCB1, ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.40324
[BP] GO:0007200 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, ESR1 3.38047
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.38047
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.36913
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.36913
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP3K7, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.34003
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.29548
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.27893
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA 3.2446
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MAP3K7, MMP12, MMP2, PPARA, PTPN1, PTPRS, RELA, SMAD3, SRC, TEK 3.2446
[BP] GO:0043405 regulation of MAP kinase activity ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC 3.23234
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 3.20455
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 3.20455
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.17292
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.16632
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, KDR, MAP2K1, PTPN1, SRC, TEK 3.15382
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.10887
[BP] GO:0050790 regulation of catalytic activity ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, MAP2K1, MAP3K7, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.09796
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.09796
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MMP9, PTPN1, RELA, SRC, TERT 3.09698
[BP] GO:0001932 regulation of protein phosphorylation ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TEK, XDH 3.09698
[BP] GO:0071396 cellular response to lipid AR, AXL, CDK6, EGFR, ESR1, FLT3, RELA, RORC, SLC6A4, SRC 3.08542
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, EGFR, FDPS, HSD11B2, HSPA1A, INSR, KDR, MAP2K1, MET, MMP1, MMP12, RELA, SLC6A4, SMAD3, SRC 3.07455
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.07201
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, HSPA1A, MAOA 3.07201
[BP] GO:0031399 regulation of protein modification process ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PTPN1, RELA, SRC, TEK, XDH 3.05773
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.05773
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 3.05253
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 3.0396
[BP] GO:0003018 None ADRA2A, CHRM1, CHRM3, EGFR, SLC6A4, SRC, TEK 3.03344
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.03117
[BP] GO:0019216 regulation of lipid metabolic process ADRA2A, CHRM5, CYP1A1, FABP3, FDPS, FLT3, PPARA, RORC, SRC, TEK 3.03117
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.02496
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, HSPA1A, RELA, SRC, TERT 3.02496
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA 3.00161
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.00128
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, INSR, KDR, MAP2K1, NUAK1, PIM1, PPARA, PTPRS, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH 3
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.99444
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, TYR 2.96715
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 2.96715
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 2.96715
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.96715
[BP] GO:0043085 positive regulation of catalytic activity ADRA2A, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, MAP2K1, MAP3K7, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 2.94867
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CES1, CYP19A1, FDPS, HSD17B3, TYR 2.93535
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, TYR 2.88165
[BP] GO:0040008 regulation of growth APP, AR, BCL2, CSNK2A1, EGFR, ESR2, HSPA1A, INSR, PIM1, PTPRS, SLC6A4, SMAD3, TNKS2 2.87352
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, FUT7, GBA2, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 2.85146
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.8437
[BP] GO:0006950 response to stress ACHE, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, MAP2K1, MAP3K7, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, RELA, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A 2.83818
[BP] GO:1902893 None PPARA, RELA, SMAD3, TERT 2.81708
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.81708
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HSD17B3 2.77122
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, RELA, SLC6A4, SRC 2.75759
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, GLO1, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.74556
[BP] GO:0009115 None AOX1, XDH 2.74556
[BP] GO:0015872 None CHRM5, SLC6A2, SLC6A4 2.74058
[BP] GO:0051254 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.71619
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, EGFR, ESR1, F3, FABP4, KDR, MAP2K1, MET, MMP12, PPARA, PTPRS, RELA, SMAD3, TEK 2.71417
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, RELA, SRC 2.70405
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA 2.70097
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC, TEK 2.70097
[BP] GO:0009611 response to wounding ACHE, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 2.69294
[BP] GO:0051338 regulation of transferase activity ADRA2A, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC, TEK, TNKS 2.65464
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.64314
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, F3, INSR, KDR, MAP2K1, PIM1, PTPRS, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.63738
[BP] GO:0050678 None AR, CDK6, EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 2.61538
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.60499
[BP] GO:0007193 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5 2.60499
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.60499
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, MAOA, SLC6A2, SLC6A4, SMAD3 2.60499
[BP] GO:0009894 regulation of catabolic process ADRA2A, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MAP3K7, MET, PPARA, PTPN1, RELA, SMAD3 2.60499
[BP] GO:0008285 negative regulation of cell proliferation APP, AR, BCL2, CDK6, CYP1B1, FABP3, HSPA1A, MAP2K1, PTGES, SLC6A4, SMAD3, TERT, XDH 2.59455
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, SMAD3, SRC, TEK 2.57852
[BP] GO:0009892 negative regulation of metabolic process ADRA2A, APEX1, APP, AR, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.57146
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, MMP1, MMP9, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.57071
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.56248
[BP] GO:0043269 regulation of ion transport ABCB1, ADRA2A, APP, BCL2, CA2, CA7, CACNA1C, CHRM1, GPR35, KCNH2, MMP9, SLC6A4 2.56248
[BP] GO:0046683 response to organophosphorus APEX1, APP, RELA, SLC6A4, TEK, TYR 2.53805
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTPN1, RELA, SRC, XDH 2.53193
[BP] GO:0045893 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.52597
[BP] GO:1903508 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.52597
[BP] GO:1902680 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.52317
[BP] GO:0044092 negative regulation of molecular function ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.5217
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, RELA, SLC6A4, SRC 2.5217
[BP] GO:0043406 positive regulation of MAP kinase activity ADRA2A, EGFR, FLT3, INSR, MAP2K1, MAP3K7, PTPN1, SRC 2.5217
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, APEX1, AR, EGFR, ESR1, FLT3, INSR, RELA, SRC 2.51871
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, TERT, TNKS 2.51773
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HSD11B2, RELA, SLC6A4, SRC, TYR 2.49194
[BP] GO:1903798 None EGFR, ESR1, MAP2K1 2.48929
[BP] GO:0051937 None CHRM5, SLC6A2, SLC6A4 2.48929
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.48929
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, RELA, TYR 2.48101
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, MAP2K1, SRC, TEK 2.48094
[BP] GO:1901224 None APP, EGFR, MAP3K7, RELA 2.47222
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.43465
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.43405
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.42067
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.41126
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, RELA, SRC 2.40898
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, AXL, BCL2, CA2, CA9, CACNA1C, CYP1B1, EGFR, ESR1, INSR, MET, MMP2, RELA, SLC6A4, SMAD3, SRC, TEK 2.40791
[BP] GO:0043549 regulation of kinase activity ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC, TEK 2.40523
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, GLO1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.3971
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, INSR, PPARA, RELA, SRC, TEK 2.39275
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.39111
[BP] GO:0003013 None ADRA2A, CHRM1, CHRM3, EGFR, SLC6A4, SRC, TEK 2.39111
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.3734
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA 2.37074
[BP] GO:0031401 positive regulation of protein modification process ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TEK, XDH 2.36917
[BP] GO:0033590 None EGFR, RELA 2.36917
[BP] GO:0046110 None AOX1, XDH 2.36917
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.36917
[BP] GO:0002520 None CACNA1C, SMAD3 2.36917
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, RELA, SRC 2.36874
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.35841
[BP] GO:0019222 regulation of metabolic process ACHE, ADRA2A, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.34426
[BP] GO:0014074 response to purine-containing compound APEX1, APP, RELA, SLC6A4, TEK, TYR 2.32155
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.31003
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.29125
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADRA2A, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.28915
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.28915
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, GPR35, KCNH2, SMAD3 2.24263
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, MAP3K7, NUAK1, PPARA, SMAD3, SRC, TEK 2.24263
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MMP9, PTPN1, RELA, SMAD3, SRC, TERT 2.23299
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 2.23139
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.22544
[BP] GO:0051591 None APEX1, APP, RELA, TEK, TYR 2.2156
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.2156
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, SRC 2.20045
[BP] GO:2001236 regulation of extrinsic apoptotic signaling pathway AR, BCL2, HSPA1A, RELA, SRC, TERT 2.20045
[BP] GO:0051090 regulation of DNA binding transcription factor activity APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, MAP3K7, PIM1, RELA 2.18679
[BP] GO:0045859 regulation of protein kinase activity ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC 2.18257
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, INSR, KDR, MAP2K1, PIM1, RELA, SMAD3, SRC, TEK, TERT 2.18164
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.17397
[BP] GO:0051347 positive regulation of transferase activity ADRA2A, AURKB, CDC25B, EGFR, FLT3, INSR, MAP2K1, MAP3K7, PTPN1, SRC, TEK, TNKS 2.16797
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MAP2K1, MAP3K7, MMP9, NUAK1, PTPN1, RELA, SRC, TERT, TOP2A 2.16582
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, EGFR, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PTPN1, RELA, SRC, TEK 2.1632
[BP] GO:0002682 regulation of immune system process ALOX15, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DUSP3, ESR1, ESRRA, HSPA1A, MAP3K7, MMP12, MMP2, PTPN1, PTPRS, RELA, SMAD3, SRC 2.16058
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, APP, AR, AURKB, BCL2, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.15368
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.15368
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.15368
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.13808
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.13808
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.13808
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.13808
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, MAP2K1, RELA, TERT 2.13613
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.13385
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.13385
[BP] GO:0048638 regulation of developmental growth APP, AR, BCL2, INSR, PIM1, PTPRS, SLC6A4, TNKS2 2.13385
[BP] GO:0051172 None ADRA2A, APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.13385
[BP] GO:0015844 None CHRM5, SLC6A2, SLC6A4 2.13385
[BP] GO:0070213 None TNKS, TNKS2 2.13385
[BP] GO:0006145 None AOX1, XDH 2.13385
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.13385
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.13278
[BP] GO:0080090 regulation of primary metabolic process ADRA2A, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.12239
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, HSD11B2, RELA, SLC6A4, SRC, TYR 2.08481
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.08348
[BP] GO:1902895 None RELA, SMAD3, TERT 2.08231
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.08231
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.08231
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, MAP2K1, TEK, TYR 2.06975
[BP] GO:0045934 None ADRA2A, APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 2.06751
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC 2.06751
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.06658
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.0627
[BP] GO:0046328 regulation of JNK cascade APP, DUSP3, EGFR, IGF1R, MAP3K7, PTPN1 2.04874
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.04874
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.03329
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, ESR2, HSPA1A, MAP3K7, RELA 2.03284
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, RELA, SMAD3, SRC 2.01228
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.01228
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADRA2A, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GBA2, GLO1, GPR35, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPN1, PTPRS, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 4.27472
[CC] GO:0016020 membrane ABCB1, ACHE, ADRA2A, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPR35, HSD11B1, HSD11B2, HSD17B2, HSD17B3, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, PTPN1, PTPRS, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR 3.60376
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CDC25B, CDK6, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PTGES, PTPN1, PTPRS, RELA, SLC6A4, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.40324
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.23176
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTPN1 2.98112
[CC] GO:0044459 plasma membrane part ABCB1, ADRA2A, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, DUSP3, EGFR, F10, F3, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PTPRS, SLC6A2, SLC6A4, SRC, TEK 2.85281
[CC] GO:0031226 intrinsic component of plasma membrane ADRA2A, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SLC6A2, SLC6A4, TEK 2.76733
[CC] GO:0016323 basolateral plasma membrane ADRA2A, CA2, CA4, CA9, CHRM3, EGFR, TEK 2.60499
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA6, CBR1, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RELA, RORC, SHBG, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.52621
[CC] GO:0005783 None APEX1, APP, BCL2, CA4, CES1, CES2, CYP19A1, FLT3, GBA2, HSD17B3, HSPA1A, KDR, MAP2K1, PTPN1, XDH 2.48929
[CC] GO:0043226 organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA6, CA9, CACNA1C, CBR1, CDK6, CES1, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RELA, RORC, SHBG, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.41126
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, CA4, EGFR, F3, KCNH2, MET, SLC6A2, TEK 2.38966
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, KCNH2, PTGES, SRC, TNKS2, TYR 2.36917
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 2.26549
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 2.24618
[CC] GO:0031233 None CA4, F10, F3 2.17347
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, F10, F3, FDPS, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, PTPN1, PTPRS, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 16.7262
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 14.641
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 14.4597
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.2783
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, GLO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.71332
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3, TNKS 7.61878
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.23096
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, GLO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.99975
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.94536
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 6.90047
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PPARA, SLC6A4, SRC, TEK, TOP2A 6.84046
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC, SHBG 6.79933
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.59304
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.35624
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.0567
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.92732
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.92732
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.85986
[MF] GO:0042562 hormone binding ACHE, AR, CHRM3, EGFR, HSD17B1, IGF1R, INSR, SHBG 5.66076
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.47514
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 5.45219
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.37853
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, GLO1 5.31935
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH 4.77977
[MF] GO:0004871 signal transducer activity ADRA2A, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, PPARA, RORC, SMAD3, TEK 4.69725
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.6616
[MF] GO:0038023 signaling receptor activity ADRA2A, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 4.64533
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, SHBG 4.56386
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.523
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 4.45206
[MF] GO:0044877 macromolecular complex binding ACHE, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SLC6A4, SMAD3, SRC 4.41581
[MF] GO:0032403 protein complex binding ACHE, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SLC6A4, SMAD3, SRC 4.39517
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.37803
[MF] GO:0060089 molecular transducer activity ADRA2A, AR, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 4.1564
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 3.99057
[MF] GO:0004872 receptor activity ADRA2A, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 3.86758
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTGES, PTPRS, RELA, SRC, TEK, TOP2A, TUBB3, XDH 3.76364
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.74695
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TERT 3.72933
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MAP3K7, MET, MMP9, RELA, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 3.56892
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.54982
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HSPA1A, KCNH2, MET, PPARA, PTPN1, RELA, SLC6A4, SMAD3, SRC, TEK, TNKS2, TOP2A 3.45761
[MF] GO:0016788 None ACHE, ALPL, APEX1, CA1, CA2, CDC25B, CES1, CES2, CHRM1, CHRM3, CHRM5, DUSP3, MAP2K1, PTPN1, PTPRS 3.4442
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.36913
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 3.18469
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.1695
[MF] GO:0008227 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5 3.11047
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.08487
[MF] GO:0042578 None ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, MAP2K1, PTPN1, PTPRS 3.00528
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK 2.82743
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD11B2, HSD17B1, PTGES, SRC, XDH 2.75308
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.74556
[MF] GO:0003845 None HSD11B1, HSD11B2 2.74556
[MF] GO:0008134 transcription factor binding APEX1, AR, BCL2, ESR1, ESRRB, FLT3, PIM1, PPARA, RELA, SMAD3, SRC, TERT 2.66902
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, MAP2K1, MAP3K7, SMAD3 2.66612
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.60499
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 2.57071
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 2.42127
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.40461
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 2.36917
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 2.36917
[MF] GO:0005330 None SLC6A2, SLC6A4 2.36917
[MF] GO:0047374 None CES1, CES2 2.36917
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.33275
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SHBG, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.28394
[MF] GO:0016787 None ABCB1, ACHE, ALOX15, ALPL, APEX1, CA1, CA2, CDC25B, CES1, CES2, CHRM1, CHRM3, CHRM5, DUSP3, F10, F3, GBA2, HSPA1A, MAP2K1, MMP1, MMP12, MMP2, MMP9, PTPN1, PTPRS, TOP2A, TUBB3 2.21672
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.2156
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 2.20045
[MF] GO:0036094 small molecule binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 2.18679
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.18679
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.17347
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, FLT3, KCNH2, RELA, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 2.1675
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADRA2A, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RELA, RORC, SHBG, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TUBB3, XDH 2.15368
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.13385
[MF] GO:0051425 None APP, INSR 2.13385
[MF] GO:0005497 None AR, SHBG 2.13385
[MF] GO:0004725 None CDC25B, DUSP3, MAP2K1, PTPN1, PTPRS 2.13278
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.10646
[MF] GO:0047485 None CSNK2A1, HSPA1A, MAP2K1, RELA, TERT 2.06658
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.03329


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 12.1106
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 9.2031
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.4234
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MAP3K7, MET, EGFR, IGF1R 8.4234
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, MAOA, ALOX15, HSD17B3, AKR1B1, TYR, CYP2C19, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES, CES1 6.4458
Pathways in cancer_Homo sapiens_hsa05200 MAP2K1, SMAD3, FLT3, MMP1, MMP2, MMP9, EGFR, RELA, IGF1R, AR, CDK6, BCL2, MET 5.9957
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 6.1774
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, MAP2K1, CHRM1, CHRM5, BCL2, CACNA1C 5.9772
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, CDK6, CHRM1, INSR, KDR, BCL2, TEK, MET, EGFR, RELA, IGF1R 5.9352
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9, EGFR 6.0133
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, ALOX15, CACNA1C, CYP2C19, SLC6A4 5.9772
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.1206
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, INSR, BCL2, TEK, EGFR, RELA, IGF1R 5.0959
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, CDK6, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 4.7719
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, EGFR, RELA, IGF1R 4.3658
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, CDK6, SMAD3, SRC, BCL2, MMP9, RELA 4.2207
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.1673
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1, F3, RELA 4.1174
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.7964
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, INSR, KDR, TEK, MET, EGFR, RELA, IGF1R 3.9996
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP2C19 4.5481
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, DUSP3, CACNA1C, MAP3K7, EGFR, RELA, CDC25B, HSPA1A 3.7247
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, CYP2C19, PTGES 4.0152
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, SMAD3, EGFR, RELA 3.9208
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6, MET, EGFR, IGF1R 3.7841
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, ESR1, ESR2, RELA 3.7721
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, BCL2, MET, EGFR, IGF1R 3.5003
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, MAP2K1, CHRM1, SRC, CHRM5, EGFR 3.3601
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 3.76
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C, EGFR 3.3601
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, CACNA1C, EGFR 2.9158
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.9129
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA, HSPA1A 2.8948
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.0429
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, MAP2K1, CHRM1, CACNA1C, PPARA, RELA 2.7997
Glioma_Homo sapiens_hsa05214 MAP2K1, CDK6, EGFR, IGF1R 2.8864
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, MAP3K7, RELA, HSPA1A 2.7196
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, SMAD3, INSR, EGFR, IGF1R 2.7542
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET, EGFR 2.8474
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR, RELA 2.8342
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, SMAD3, RELA 2.7698
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1, CYP2C19 2.8321
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, GPR35, CHRM5, ADRA2A 2.1563
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.219
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, MAP3K7, RELA, HSPA1A 2.0423
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.185
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA, RELA 2.1912
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8321
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, TUBB3, EGFR 2.5007
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, MAP3K7, RELA 2.42
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, SMAD3, ESRRB, IGF1R 1.8548
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, EGFR 1.706
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, INSR, CACNA1C, ADRA2A 1.648
Influenza A_Homo sapiens_hsa05164 FDPS, MAP2K1, RELA, HSPA1A 1.5924
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.5385
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC, EGFR 1.648
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, RELA, IGF1R 1.5814
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, RELA 1.6486
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.0011
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.4703
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.4866
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, BCL2, RELA 1.3498
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC, ESR1 1.358
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.957
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.3285
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, CDK6, EGFR 2.0914
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, BCL2, RELA 1.3498
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, MAP3K7, IGF1R 1.3285
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, SMAD3, BCL2 1.9889
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.2743
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.3285
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.2386
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR, RELA 1.2743
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1, INSR 1.2397
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2478
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC, RELA 1.9527
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, MAP3K7 1.2337
HTLV-I infection_Homo sapiens_hsa05166 FDPS, SMAD3, TERT, RELA 1.1967
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1692
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.284
Phagosome_Homo sapiens_hsa04145 TUBB3 0.284
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 1.9527
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, INSR, EGFR 1.2243
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA, RELA 1.1899
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3193
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.3193
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1605
Axon guidance_Homo sapiens_hsa04360 MET 0.3339
Platelet activation_Homo sapiens_hsa04611 SRC 0.3443
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.364
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.0661
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.0369
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6203
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC, RELA 0.9566
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4021
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.5959
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6203
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4021
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.0328
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4051
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.4021
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4133
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.4157
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C 0.6946
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4133
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7319
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.426
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.426
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4246
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4362
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.7685
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4304
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8173
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.426
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.296
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.8105
Peroxisome_Homo sapiens_hsa04146 XDH 0.4378
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4413
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4378
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 0.9205
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, RELA 0.9017
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4521
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, EGFR 0.9201
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4541
Pertussis_Homo sapiens_hsa05133 RELA 0.4609
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.9439
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4632
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9855
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.4887
Taste transduction_Homo sapiens_hsa04742 CHRM3, CACNA1C 1.0328
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.486
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.9991
Insulin secretion_Homo sapiens_hsa04911 CHRM3, CACNA1C 1.0183
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.1055
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0657
Renin secretion_Homo sapiens_hsa04924 CACNA1C 0.5085
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5085
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.1055
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.0988
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.1264
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0596
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.1605
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.1193
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.1605
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.2386
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.1264
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.1527
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.2061
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.1605
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, EGFR 1.2743
Legionellosis_Homo sapiens_hsa05134 RELA, HSPA1A 1.2397
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.2337
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.56
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2151
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.6176
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP2C19 2.8119
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.3075
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5862
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, CACNA1C 1.3191
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5909
Malaria_Homo sapiens_hsa05144 MET 0.5959
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6035
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5983
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, INSR 1.452
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6035
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6203
Prion diseases_Homo sapiens_hsa05020 MAP2K1, HSPA1A 1.5188
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1, EGFR 1.6803
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6174
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6519
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6519
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5814
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5013
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7592
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7385
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7194
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8035
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7592
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.791
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7486
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7788
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8173
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8462
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9363
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9201
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9129
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2397


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)