TCM Prescription: Ling Zhi Yi Shou Capsules



Prescription Description
Prescription IDTCMF4328
Pinyin NameLing Zhi Yi Shou Jiao Nang
Chinese Name灵芝益寿胶囊
English NameLing Zhi Yi Shou Capsules
Function Description自汗, 不寐, 胸痹, 眩晕
IndicationsVertigo disorder, Insomnia disorder, Insomnia, Chest pain, Dizziness
Disease ICD-11 Category SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
MD30.Z [Chest pain, unspecified, 胸痛，未特指的 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
Human Tissues Associated with IndicationHeart, Lung, Brain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1299 Ganoderma lucidum 灵芝 TCMH1299 MGEN736-15
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH1791 Loranthus parasiticus 桑寄生 TCMH1791
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1351 Nocardia sp.
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 14.3753
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FABP3, FUT7, GLO1, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 11.476
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, TYR, XDH 10.4618
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 9.9468
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 9.64258
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 9.37315
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 9.37315
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 9.31981
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, NQO2, PTGS1, RORC 9.31981
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 9.1671
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 9.10579
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 8.48078
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.45562
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 8.44484
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, KCNH2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 8.37152
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 8.19893
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 8.12576
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 8.08755
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 8.06394
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 7.83869
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 7.67247
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 7.49583
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.49583
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 7.20613
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 7.15296
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, PPARA, PTGS1, PTGS2 7.02304
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, NR3C1, PPARA, PTGS2, SLC6A4, SRC, TRPV1 7.01301
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TERT, TRPV1 6.89614
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 6.59324
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.50073
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, PTGS2, RORC, SLC6A4, SRC, TYR 6.49471
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, NR3C1, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 6.45806
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC, TERT 6.31159
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 6.23491
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, PTGS2, SLC6A4, SRC, TRPV1 6.17639
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA6, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1, TYR 6.17639
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SLC6A4, SRC, TERT, XDH 6.17639
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6, CYP3A4 6.04234
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1, TYR, XDH 5.75424
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.69529
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 5.63706
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, APEX1, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TRPV1 5.52547
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 5.4845
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 5.45154
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 5.42956
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 5.42956
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1 5.36006
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 5.32816
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA9, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SLC6A4, SRC, TERT, TOP2A, TYR 5.32816
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 5.30774
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 5.27057
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 5.14616
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 5.09559
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1, TYR, XDH 5.08865
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.02597
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2 5.00807
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 4.94536
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 4.839
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KCNH2, KDR, NR3C1, PTGS2, SLC6A2, SLC6A4, SRC, TRPV1 4.83228
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, ALOX12, APEX1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, PIK3CA, PIK3CB, SRC, TERT, TRPV1 4.83228
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, RORC, SLC6A4, SRC, TRPV1 4.82563
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, APEX1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT, TRPV1 4.80658
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 4.8038
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TRPV1 4.71848
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KCNH2, KDR, NR3C1, PTGS2, SRC, TRPV1 4.71848
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.64741
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TRPV1, TYR 4.566
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4 4.51512
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.39703
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 4.35463
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 4.28907
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.1879
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, TRPV1 4.12928
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4 4.08822
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.06893
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 3.96267
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1, XDH 3.90026
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 3.89366
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.84698
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC 3.79118
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.72833
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.72663
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, HCAR2, KDR, PIK3CB, PTGS2, SRC, TRPV1 3.63995
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1, XDH 3.60394
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 3.56116
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.55337
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 3.55268
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.52132
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.5184
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.46157
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.45099
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CYP1B1, FLT3, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.42654
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, TYR 3.42203
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 3.36871
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR 3.34751
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.32719
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS1, PTGS2 3.21943
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.21417
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.20372
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.19877
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 3.16698
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, PTGS1, PTGS2 3.16056
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, TRPV1 3.15682
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 3.1387
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.13514
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 3.11595
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HCAR2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1, TYR, XDH 3.0982
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.07397
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.05011
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 3.02056
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.02043
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, ESR1, FLT3, IGF1R, MMP2, NR3C1, PTGS2, SLC6A4, SRC, TRPV1 3.01459
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.01361
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, AURKB, CSNK2A1, CYP2D6, ESR1, ESR2, ESRRA, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 2.97808
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, CA12, CA2, CA7, ESR1, FABP3, FABP4, KCNH2, MET, PIK3CA, PIK3CB, TRPV1 2.97575
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.96655
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, AXL, CA2, CA7, CYP19A1, HCAR2, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT, TRPV1 2.96401
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.91476
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1 2.90773
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.90248
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.90248
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, HCAR2, KCNH2, MMP12, PTGS2, SLC6A4, SRC, TERT, TRPV1 2.90248
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, RORC, SLC6A4, SRC, TOP2A 2.89923
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2C19, CYP3A4 2.87167
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.87167
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.87167
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 2.83733
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.83733
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.79305
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.78792
[BP] GO:0009115 None AOX1, XDH 2.78792
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.78792
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.78792
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.78792
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CES1, CYP1A1, CYP1B1, KDR, SLC6A4, SRC 2.7168
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.69611
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.68464
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.63385
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX12, ALOX15, CYP19A1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.61534
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2, TERT 2.59688
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4 2.59385
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 2.57239
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.55732
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.53681
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.49254
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 2.48455
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.43941
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.43639
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.40488
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.40488
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.39183
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.39183
[BP] GO:0046110 None AOX1, XDH 2.39183
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.39183
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.39183
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.38677
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, PPARA, PTGS2, SRC, TRPV1 2.3795
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.37784
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.37545
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 2.37089
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.36868
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.36171
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.36171
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 2.34493
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.34132
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.32997
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, SRC 2.29759
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.28318
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 2.28282
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 2.26932
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.25053
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APEX1, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 2.24895
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ALOX12, AXL, CA2, CYP1B1, ESR1, ESRRA, ESRRB, HCAR2, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SLC6A4, SRC, TERT, TRPV1, XDH 2.2416
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2C19, CYP2D6, CYP3A4 2.2416
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.2416
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, ALOX12, CYP19A1, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.22548
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT, TRPV1, TYR 2.2193
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.21033
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.20796
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.20796
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.20796
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, TRPV1 2.20022
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.19675
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, AURKB, CSNK2A1, CYP2D6, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 2.19128
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.18691
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, MMP12, SLC6A4, SRC, TRPV1 2.1792
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.1792
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.1792
[BP] GO:0006145 None AOX1, XDH 2.1792
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.1792
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.1792
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.1792
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1792
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.13209
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, PTGS2, SLC6A4 2.13198
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.1289
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, PTGS2, SLC6A4 2.12195
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.11208
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.10867
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, IGF1R, MMP2, PTGS2, SLC6A4, SRC, TRPV1 2.10348
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, FLT3, KDR, PIK3CB, PTPN1, SRC, XDH 2.08699
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, SRC, TERT 2.06977
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.0664
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APEX1, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 2.05063
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.04712
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ALOX12, AXL, CA2, CYP1B1, ESRRB, HCAR2, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT, TRPV1 2.04712
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.04712
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.04712
[BP] GO:0006693 None CES2, PTGS1, PTGS2 2.04712
[BP] GO:0006692 None CES2, PTGS1, PTGS2 2.04712
[BP] GO:0046683 response to organophosphorus APEX1, PTGS2, SLC6A4, TRPV1, TYR 2.04712
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, PIK3CB, SRC, XDH 2.04709
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, CSNK2A1, ESRRB, HCAR2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1 2.04709
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.03573
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.02495
[BP] GO:0051896 regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC, XDH 2.02282
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.00747
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.00747
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 2.00286
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, AURKB, CA1, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, KCNH2, KDR, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A4, SRC, TERT, TOP2A, TRPV1, TYR, XDH 3.21943
[CC] GO:0044432 endoplasmic reticulum part CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 2.2597
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, FLT3, FUT7, GLO1, HCAR2, HSD11B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 2.13784
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TRPV1 2.12195
[CC] GO:0005783 None ADORA1, APEX1, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, KDR, PTGS2, PTPN1, XDH 1.9483
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, RORC, TYR, XDH 20.3511
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1, TYR, XDH 13.4219
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TOP2A, TYR, XDH 12.4236
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 12.2156
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 10.6464
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TOP2A, TRPV1, TYR, XDH 10.6464
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TOP2A, TRPV1, TYR, XDH 10.3039
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, XDH 9.1557
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1, RORC 9.09266
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.19893
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.78149
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 7.60644
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 7.31844
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.9939
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR 6.89614
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4 6.87127
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.68002
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, RORC 6.38895
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, GLO1 6.24952
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 6.12526
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 6.11897
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, TYR 6.11221
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SRC, TOP2A, TRPV1 5.75319
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.153
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.153
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 4.48905
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP2D6, CYP3A4 4.4668
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 4.02206
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, HSD17B2, XDH 3.86464
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 3.72449
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, NQO2, PTGS2, SLC6A4, TERT, TOP2A, TRPV1, TYR, XDH 3.70899
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 3.52132
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.39013
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.33191
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.32719
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.27775
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.20372
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.96655
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.90248
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.85896
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.78792
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.78792
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.78792
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.76434
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, NQO2, NR3C1 2.73593
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.62695
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.62284
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, SRC 2.54956
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.52415
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 2.49298
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, TERT, TOP2A, TYR, XDH 2.48455
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.42687
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.39183
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.39183
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.39183
[MF] GO:0005330 None SLC6A2, SLC6A4 2.39183
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.39183
[MF] GO:0047374 None CES1, CES2 2.39183
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 2.32419
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.30314
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.2906
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.24039
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT 2.19675
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.1792
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.1792
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.1792
[MF] GO:0032795 None ADORA1, ADRA2A 2.1792
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.1792
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.00747
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.00747
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.00747


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 13.2331
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.2303
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.8633
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP2C19, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 6.7231
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5, ALOX15, ALOX12, PTGS2, CYP2C19, PTGS1, SLC6A4 6.7231
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.0774
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.0774
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 6.0067
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4, CYP2C19 6.4027
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12, PTGS2, CYP2C19, PTGS1 5.9045
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.5167
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.5154
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R 4.0226
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.2541
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1, CYP3A4, CYP2C19 4.3157
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.2233
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 3.7452
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.2895
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.2883
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.2549
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.4363
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0052
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.4764
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9855
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH, CES2, CES1 3.8063
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.2727
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.2895
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB, ADRA2A 2.8339
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.2218
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PIK3CB 2.7022
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.739
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2549
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.0921
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA 2.5501
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5869
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.5896
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.3498
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.4751
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.5074
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.5074
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.4911
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, PIK3CB, MMP9 2.2465
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.2724
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, AOX1, PIK3CB 2.1398
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.1398
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1, NR3C1, ADRA2A 2.0575
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.2724
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9805
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2816
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, PIK3CB, MET, IGF1R 1.7703
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.9923
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2724
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, IGF1R 1.9805
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.9219
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, PIK3CB 1.7703
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 1.9978
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, PIK3CB, IGF1R 1.8339
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5637
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 1.7135
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.6615
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.5988
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.583
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.5988
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.488
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.5658
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB 1.2361
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2229
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.2249
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.1832
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3161
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3125
Purine metabolism_Homo sapiens_hsa00230 XDH 0.322
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3215
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, TERT, PIK3CB 1.0309
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0119
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3886
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4286
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4286
Axon guidance_Homo sapiens_hsa04360 MET 0.4234
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.9194
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9194
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.934
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9465
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.7894
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.8904
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.9066
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.0119
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4951
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0956
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4951
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.1196
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1779
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1702
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1059
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1228
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5047
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1059
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4951
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5042
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1339
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5173
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5181
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5198
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5198
Gap junction_Homo sapiens_hsa04540 SRC 0.5198
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.1702
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.519
Peroxisome_Homo sapiens_hsa04146 XDH 0.5315
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3286
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.3286
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3653
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5732
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5714
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5857
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.3789
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3408
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.3408
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4401
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3653
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.4188
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6108
Shigellosis_Homo sapiens_hsa05131 SRC 0.6108
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6108
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6313
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.4853
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4482
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.5348
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6115
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.583
Malaria_Homo sapiens_hsa05144 MET 0.7075
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.7135
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7167
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.712
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8837
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7749
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8362
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7781
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7703
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8706
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8486
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0575
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8904
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9194
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8804
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9083
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2185
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4112


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)