TCM Prescription: Jing Wan Hong



Prescription Description
Prescription IDTCMF4323
Pinyin NameJing Wan Hong
Chinese Name京万红
English NameJing Wan Hong
Function Description水火烫伤, 疮疡
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationSkin
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH462 Sanguisorba officinalis 地榆 TCMH462 GENG545-14, GBVT2403-13
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH1511 Momordica cochinchinensis 木鳖子 TCMH1511 ITSAJ4256-14
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
TCMH2357 Crinis carbonisatus 血余炭 TCMH2357
TCMH2736 Petiolus trachycarpi 棕榈 TCMH2736
TCMH122 Lobelia chinensis 半边莲 TCMH122 ITSAL4535-14
TCMH2129 Eupolyphaga sinensis 土鳖虫 TCMH2129 GBMIN33972-13
TCMH293 Manis pentadactyla 穿山甲 TCMH293 GBMA15413-17
TCMH86 Ampelopsis japonica 白蔹 TCMH86 ITSAJ4449-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH2706 Lithospermum erythrorhizon 紫草 TCMH2706
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH2175 Galla chinensis 五倍子 TCMH2175
TCMH938 Sophora japonica 槐花 TCMH938 ITSAN2377-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH905 Picrorhiza kurrooa 胡黄连 TCMH905 GBVX6435-15, GBVX5995-15
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
TCMH2348 Sanguis draconis 血竭 TCMH2348
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT263 SOAT2 Acyl coenzyme A:cholesterol acyltransferase 2 Transferase O75908
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT644 HTR3A Serotonin 3a (5-HT3a) receptor Ion channel P46098
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1174 Mycobacterium bovis BCG
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1184 Mycobacterium fortuitum
TCMT1185 Mycobacterium phlei
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1193 Staphylococcus
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1200 Bacillus thuringiensis
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1216 Vibrio cholerae
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1260 Streptococcus agalactiae
TCMT1262 Mycoplasma putrefaciens
TCMT1266 Mycobacterium abscessus
TCMT1267 Mycobacterium chelonae
TCMT1268 Nocardia farcinica
TCMT1269 Mycobacterium ulcerans
TCMT1270 Streptomyces coelicolor
TCMT1271 Shigella flexneri
TCMT1273 Pseudomonas putida
TCMT1275 Erwinia chrysanthemi
TCMT1278 Pseudomonas
TCMT1279 Staphylococcus aureus subsp. aureus
TCMT1280 Salmonella sp.
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1287 Bacillus subtilis subsp. spizizenii ATCC 6633
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1303 Bacillus
TCMT1305 Salmonella enteritidis
TCMT1311 Pseudomonas tolaasii
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1325 Mycobacterium gordonae
TCMT1326 Shigella
TCMT1328 Enterococcus avium
TCMT1329 Bacillus fortis
TCMT1330 Salmonella enterica subsp. enterica serovar Paratyphi B
TCMT1331 Acinetobacter sp.
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1461 Salmonella enterica subsp. enterica serovar Gallinarum
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KDR, KIT, MET, MIF, OPRD1, OPRK1, OPRM1, PDE3A, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC22A1, SLC22A2, SLC22A3, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 21.7289
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TRPV1, TYR 18.7088
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, MMP9, NR3C1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, POLB, PPARA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK, TRPV1, TYR 18.0938
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR5A, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 18.0519
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 16.2547
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 16.2265
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, NR3C1, OPRK1, OPRM1, PDE3A, PRKCE, PRKCG, PTGS2, RORC, SRC, TEK, TRPV1, TYR 15.216
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, KIT, MMP2, NR3C1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1 14.724
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.5646
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.5646
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 14.1847
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 14.1223
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.7523
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, MIF, PDE3A, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SOAT1, SOAT2, TRPV1 13.7198
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.5118
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 13.4182
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 13.2711
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, KIT, NR3C1, OPRK1, PDE3B, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK, TRPV1 13.0823
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, NR3C1, OPRK1, OPRM1, PDE3A, POLB, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1 12.7326
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TERT, TRPV1 12.3158
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, DRD1, EGFR, ESR1, FABP4, FLT3, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TRPV1 12.1643
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PDE3A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 11.9964
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.9053
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD2, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, OPRM1, PGR, PIM1, PRKCA, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 11.6624
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR 11.6559
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, FUT7, GLO1, HSPA1A, HTR2B, HTR2C, MIF, PDE10A, PDE3A, PDE3B, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, SOAT1, SOAT2, TYR, XDH 11.6559
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PDE3A, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 11.6454
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, NR3C1, OPRK1, OPRM1, PRKCE, PTGS2, RORC, SRC, TYR 11.3414
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 11.3119
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 11.2255
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SENP6, SLC22A2, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 11.1533
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PDE3A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 10.796
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, DRD1, DRD2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 10.796
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.7754
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA1, CA2, CNR1, CNR2, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 10.5907
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PGR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 10.5663
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.5273
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.5273
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 10.519
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PGR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 10.5108
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, OPRK1, PRKCA, PRKCE, SLC22A1 10.5108
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SMAD3, SOAT1, SOAT2, SRC, TEK, TNKS2, TRPV1, TYR 10.4849
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, SOAT1, SOAT2 10.4836
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGS1, PTGS2 10.3887
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 10.373
[BP] GO:0007187 None ADORA1, CNR1, CNR2, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7, OPRD1, OPRK1, OPRM1 10.3298
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CNR1, DRD1, DRD2, EGFR, HCAR2, HTR2A, HTR2B, HTR2C, KDR, MIF, OPRK1, PIK3CB, PRKCE, PTGS2, SRC, TNKS, TNKS2, TRPV1 10.2749
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP2, NQO2, NR3C1, NR3C2, NUAK1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SENP6, SLC22A2, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 10.1191
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.1031
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, DRD1, DRD2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 10.099
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGS1, PTGS2 10.0409
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.99841
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 9.84375
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PGR, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 9.82426
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PGR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 9.7615
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, DRD2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, OPRK1, OPRM1, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 9.66815
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, EGFR, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 9.6502
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.6502
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, KIT, MIF, MMP2, MMP9, NR3C1, NUAK1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, POLA1, POLB, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 9.59431
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.55261
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PDE3A, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.55207
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, EGFR, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, KIT, MMP2, OPRD1, OPRK1, OPRM1, POLB, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, TYR 9.52118
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, APP, AR, AXL, CYP1B1, DNMT1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, NR3C1, OPRK1, PDE3A, PDE3B, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 9.44342
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 9.41568
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, DRD1, DRD2, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TERT, TRPV1 9.40238
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PGR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 9.40238
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PDE3A, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.37717
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.30727
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.27028
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 9.26047
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, KIT, MET, MIF, PDE3A, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SOAT1, SOAT2 9.25159
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, DRD2, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, OPRK1, OPRM1, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 9.17422
[BP] GO:0007193 None ADORA1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7, OPRD1, OPRK1, OPRM1 9.04698
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, HTR1B, HTR1D, KDR, OPRD1, OPRK1, POLB, PRKCD, PRKCE, SRC 9.01381
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, POLA1, POLB, PRKCB, PRKCE, SMAD3, SOAT1, SOAT2, SRC, TERT, TRPV1 8.92011
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, AKR1C3, APP, CA2, CNR1, CNR2, DRD1, DRD2, ESR1, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, SIGMAR1, SRC 8.8884
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APEX1, APP, AR, DNMT1, DRD1, EGFR, ESR1, FLT3, HTR1B, IGF1R, INSR, KIT, MMP2, NR3C1, OPRM1, PDE3A, PDE3B, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TRPV1 8.86192
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, KIT, PDE3B, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 8.86192
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, KIT, MMP9, PRKCD, PTGS2, SRC, TERT 8.85022
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DYRK1A, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SOAT1, SRC, TEK, XDH 8.76042
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK, TERT 8.7064
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DYRK1A, EGFR, ESR1, HTR7, KIT, OPRK1, OPRM1, PGR, PPARA, PRKCG, RORC, SRC, TOP2A 8.65428
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, HTR1D, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, OPRK1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 8.64503
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PRKCD, SRC, TEK 8.63878
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APEX1, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP2D6, DNMT1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRM1, PDE3B, PGR, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 8.5564
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 8.52704
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.40862
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCD, PTGS2, PTPRS, RORC, SIGMAR1, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS2, TOP2A, TYR 8.40862
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PDE3A, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.32308
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, CNR2, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PRKCB, PRKCD, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 8.30791
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.30739
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 8.28946
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, CNR2, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PRKCB, PRKCD, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 8.28254
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.21975
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, NR3C1, OPRM1, PDE3A, PTGS2, RORC, SRC, TRPV1 8.216
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, DRD2, HTR1B, PRKCE 8.20327
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.16861
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 8.06998
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGS1, PTGS2 8.05943
[BP] GO:0003018 None ADORA1, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PDE3A, PTGS2, SRC, TEK 8.05943
[BP] GO:0007188 None ADORA1, CNR1, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7, OPRD1, OPRK1, OPRM1 8.02739
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.97916
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.83823
[BP] GO:0007610 None APP, BCL2, CNR1, DRD1, DRD2, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, KIT, OPRD1, OPRK1, OPRM1, PPARA, PRKCE, PRKCG, PTGS2, TRPV1 7.68815
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, OPRK1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.6338
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, OPRD1, POLB, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.5763
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CNR1, CNR2, CYP19A1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, OPRK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 7.52517
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.5129
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 7.50409
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.50113
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, DRD2, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 7.49062
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, SOAT1, SOAT2, TRPV1 7.43431
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, EGFR, HTR1B, HTR2A, KIT, PRKCE, PTGS2 7.38727
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, EGFR, HTR1B, HTR2A, KIT, PRKCE, PTGS2 7.38727
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, OPRD1, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.33309
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, HTR2C, MIF, PRKCE, SRC, TNKS, TNKS2, TRPV1 7.32668
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.28247
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SENP6, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 7.28042
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.26091
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, OPRD1, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.16921
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.09588
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 7.07924
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK 7.07902
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, MIF, OPRM1, PRKCA, PTPN1, SRC, TEK 7.02454
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SENP6, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 6.99275
[BP] GO:0003008 None ADORA1, AKR1B1, AKR1C3, APP, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, EGFR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, KIT, OPRD1, OPRK1, OPRM1, PDE3A, PIK3CA, PRKCG, PTGS2, SOAT2, SRC, TEK, TRPV1, TYR 6.92009
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, PRKCG, SRC, TEK 6.88637
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.88637
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, HTR1B, KDR, NR3C1, OPRM1, PRKCD, PRKCE, PTGS2, SRC, TRPV1 6.87258
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, EGFR, HTR2A, HTR2B, HTR2C, KDR, MIF, OPRM1, PRKCA, SRC, TEK 6.86849
[BP] GO:0007154 None ADORA1, AKR1C3, AR, AXL, BCL2, CNR1, DRD1, DRD2, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, OPRD1, OPRK1, OPRM1, PGR, PRKCG, PTGS2, TEK, TRPV1 6.85029
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CNR1, DRD1, DRD2, GPR35, HTR1A, HTR1B, HTR2A, MIF, MMP9, OPRD1, OPRK1, OPRM1, PRKCD, PRKCE, PTGS2 6.84241
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSD11B2, HSPA1A, HTR1A, HTR2C, KIT, MIF, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 6.83568
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SENP6, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.81893
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.81893
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH 6.7439
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PRKCD, SRC, TEK 6.73097
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 6.72989
[BP] GO:0003013 None ADORA1, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PDE3A, PTGS2, SRC, TEK 6.6911
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, EGFR, HTR1B, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, PRKCD, PTGS2, SRC, TRPV1 6.64774
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA, PTGS1, PTGS2 6.62853
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, HTR2A, HTR2B, HTR2C, KDR, PRKCE, SRC, TRPV1 6.62345
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.62051
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.61097
[BP] GO:0099536 None CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, OPRD1, OPRK1, OPRM1, PRKCG 6.58018
[BP] GO:0099537 None CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, OPRD1, OPRK1, OPRM1, PRKCG 6.58018
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MET, MIF, MMP9, NUAK1, OPRD1, OPRM1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TRPV1, XDH 6.5174
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, EGFR, ESRRB, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, KIT, MET, MIF, MMP12, MMP9, OPRM1, PDE3A, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1 6.50764
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, EGFR, ESR1, F3, FABP4, KDR, MET, MIF, MMP12, OPRM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPRS, SMAD3, TEK 6.36997
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 6.33214
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, MMP9, NUAK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 6.27756
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, BCL2, CNR1, CNR2, CYP19A1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PDE3B, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 6.26718
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, EGFR, HTR1B, NR3C1, OPRK1, OPRM1, PRKCE, PRKCG 6.23937
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.20805
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 6.18373
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, EGFR, HTR1B, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, PRKCD, PTGS2, SRC, TRPV1 6.17302
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.15983
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, EGFR, HTR1B, HTR2A, PTGS2 6.15524
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, EGFR, F10, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SENP6, SRC, TEK, TNKS, TOP2A 6.14888
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 6.11783
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, PIK3CA, POLB, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 6.08461
[BP] GO:0007200 None DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, OPRD1, OPRK1, OPRM1 6.05863
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.04928
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SENP6, SIGMAR1, SLC22A1, SLC22A2, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 6.03226
[BP] GO:0007267 None ADORA1, AR, CNR1, DRD1, DRD2, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, OPRD1, OPRK1, OPRM1, PGR, PRKCG, TEK 5.95477
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APEX1, APP, AR, AURKB, BCL2, CNR1, CSNK2A1, CYP2D6, DNMT1, DRD2, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, NR3C1, OPRM1, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.89553
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR1B, HTR2A, PTGS2 5.88976
[BP] GO:0050795 None ADORA1, CNR1, DRD2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.88976
[BP] GO:0097746 None ADORA1, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.85544
[BP] GO:0035296 None ADORA1, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.85544
[BP] GO:0007268 None DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, OPRD1, OPRK1, OPRM1, PRKCG 5.85011
[BP] GO:0098916 None DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, OPRD1, OPRK1, OPRM1, PRKCG 5.85011
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PDE3B, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 5.8343
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AR, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, MET, MIF, MMP9, OPRD1, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.76266
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, INSR, OPRK1, PDE3B, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 5.74844
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.73337
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 5.68283
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, KIT, MET, MIF, PIK3CB, PIM1, POLA1, PRKCD, SRC, TEK, TYR 5.66793
[BP] GO:0050880 None ADORA1, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.6168
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, HTR1A, SOAT1, SOAT2, TYR 5.6038
[BP] GO:0035150 None ADORA1, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.59017
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, RORC, SRC 5.48927
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, KIT, MET, MIF, NUAK1, OPRM1, PDE3A, PIK3CA, PIK3CB, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 5.48438
[BP] GO:0006939 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, TRPV1 5.48438
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 5.46557
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, SRC 5.46526
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 5.45265
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, EGFR, HCAR2, HTR2B, INSR, MIF, MMP12, OPRK1, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TERT, TRPV1 5.44355
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, KIT, MMP9, PTGS2, TERT 5.41092
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, GPR35, HTR1B, HTR2A, MMP9, PRKCE, PTGS2 5.36991
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.36991
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.34868
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR, PDE3A 5.33338
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, EGFR, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 5.3305
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.30325
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 5.30325
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.29518
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PDE3B, PPARA, PRKCD, PRKCE 5.26275
[BP] GO:0023052 None ADORA1, AR, CNR1, DRD1, DRD2, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, OPRD1, OPRK1, OPRM1, PGR, PRKCG, TEK 5.25038
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.24221
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.21193
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.21193
[BP] GO:0043278 None CNR1, DRD2, OPRK1, OPRM1, PRKCE, PRKCG 5.21193
[BP] GO:0014072 None CNR1, DRD2, OPRK1, OPRM1, PRKCE, PRKCG 5.21193
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, NQO2, PTGS1, RORC 5.11568
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, OPRM1, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS 5.10953
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PIK3CB, PRKCD, PTPN1, SRC 5.10206
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC 5.05678
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PIK3CA, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, SENP6, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 5.01803
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, EGFR, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, SRC 5.01771
[BP] GO:0072347 None CNR1, DRD2, HTR1B, OPRK1, OPRM1, PRKCE, PRKCG 5.00387
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, KIT, MMP2, MMP9, OPRK1, OPRM1, PDE3A, PGR, PTGS2, SRC, TOP2A 4.96626
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 4.93819
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, PRKCD, PTGS2, RORC, SMAD3, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 4.93815
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, OPRK1, OPRM1, PRKCA, PRKCE, SRC, TRPV1 4.93169
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR, PRKCE, PTGS2 4.91747
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 4.90708
[BP] GO:0060359 None CNR1, DRD1, DRD2, HTR1B, OPRK1, OPRM1, PRKCE, PRKCG 4.89822
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.89019
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 4.82621
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.82621
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PPARA, PTGS1, PTGS2 4.82426
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, HTR1A, INSR, PTGS2, SLC22A2, SLC22A3, SMAD3, TRPV1 4.81894
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR, PDE3A 4.81125
[BP] GO:0043279 None CNR1, DRD2, HTR1B, OPRK1, OPRM1, PRKCE, PRKCG, TRPV1 4.79496
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, OPRK1, OPRM1, PRKCA, PRKCE, SRC 4.77243
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SENP6, SIGMAR1, SMAD3, SOAT1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.72986
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 4.71734
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 4.71541
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SOAT1, SRC, TEK, XDH 4.71237
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.71221
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 4.71058
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HCAR2, HTR2B, MET, PDE3B, PIK3CA, PPARA, PRKCG, SMAD3 4.6945
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A, HTR2C, OPRK1, PRKCA, PRKCE 4.6945
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, INSR, MIF, PRKCA, PRKCE, SRC, TERT 4.6945
[BP] GO:0007631 None APP, DRD1, DRD2, HTR1B, HTR2C, OPRD1, OPRK1, OPRM1 4.66847
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PRKCD, PTGS2, RORC, SMAD3, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 4.62321
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK 4.61211
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.60309
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.56224
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, DNMT1, DRD2, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 4.55566
[BP] GO:0050890 None ADORA1, APP, CNR1, DRD1, DRD2, EGFR, HTR2A, INSR, KIT, OPRK1, PRKCG, PTGS2 4.54866
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.50771
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, EGFR, OPRM1, PPARA, SMAD3 4.49775
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, KIT, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, PTPRS, SMAD3, SRC 4.49775
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK 4.49373
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, INSR, OPRK1, PDE3B, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 4.45607
[BP] GO:0032098 None HTR2C, HTR4, OPRM1, PPARA, SLC22A3 4.42483
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DUSP3, DYRK1A, ESR1, HSPA1A, IGF1R, MET, MIF, MMP9, PDE3B, PRKCD, PTGS2, PTPN1, SRC, XDH 4.4241
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.41592
[BP] GO:0044057 None ADORA1, ADORA3, DRD2, EGFR, GPR35, HCAR2, HTR2A, HTR2C, KIT, OPRD1, OPRK1, OPRM1, PRKCA, PTGS2, SMAD3, TRPV1 4.40462
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, HTR2A, KIT, MIF, PRKCD, PRKCE, PTPN1, SRC 4.39903
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HTR2A, MIF, POLB, PRKCD, PTGS2, TERT 4.39903
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 4.38037
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 4.38037
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.35845
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TRPV1 4.35436
[BP] GO:0019371 None AKR1C3, CBR1, PTGS1, PTGS2 4.34358
[BP] GO:0007611 None APP, CNR1, DRD1, DRD2, EGFR, HTR2A, INSR, KIT, OPRK1, PRKCG, PTGS2 4.33329
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, HSPA1A 4.31807
[BP] GO:0032870 cellular response to hormone stimulus AKR1C3, APEX1, AR, EGFR, ESR1, FLT3, INSR, KIT, NR3C1, PDE3B, PRKCD, PRKCE, SRC 4.31735
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CNR1, DRD2, EGFR, HCAR2, HTR2B, HTR2C, MIF, MMP12, OPRM1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 4.30469
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, HTR2A, HTR2B, HTR2C, OPRM1, PPARA, PRKCB, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 4.28508
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, PDE3A, PGR, PTGS2, SRC 4.27705
[BP] GO:0008217 None ADORA1, AR, CNR1, DRD2, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 4.22777
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, HTR1B, HTR2A, OPRK1 4.22757
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2, TERT 4.22757
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 4.21318
[BP] GO:0015872 None DRD1, SLC22A1, SLC22A2, SLC22A3 4.18796
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F3, HTR2A, HTR2C, INSR, KDR, KIT, MIF, NUAK1, OPRM1, PDE3A, PDE3B, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH 4.16638
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, PRKCA, PRKCB, PRKCD, TNKS 4.15792
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK, TNKS 4.14779
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 4.13642
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 4.13071
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.1197
[BP] GO:0016572 histone phosphorylation AURKB, DRD1, PRKCA, PRKCB, PRKCD 4.11451
[BP] GO:0014059 None CNR1, DRD2, HTR1B, HTR2A, OPRK1 4.11451
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.10717
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, HSPA1A, INSR, MIF, PDE3A, PIM1, PRKCA, PRKCE, PTGS2, SENP6, SMAD3, SRC, TERT, TNKS, TOP2A 4.08521
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SENP6, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 4.06329
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.05671
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 4.04282
[BP] GO:0051172 None APEX1, APP, AR, AURKB, CSNK2A1, DNMT1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR1B, HTR1E, IGF1R, MIF, MMP12, MMP9, NR3C1, OPRM1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.04273
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.03298
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, ESRRB, F3, HTR2A, HTR2C, INSR, KDR, KIT, OPRM1, PDE3A, PIM1, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK, TERT 4.03114
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 4.02566
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET, PIK3CA, TRPV1 4.02566
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DNMT1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 4.0094
[BP] GO:0090066 None ADORA1, ALOX15, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PRKCD, PRKCE, PTGS2 4.0094
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HTR5A, INSR, KDR, KIT, MMP9, PGR, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPRS, RORC, SIGMAR1, SMAD3, SRC, TEK, TYR 4.00922
[BP] GO:0019233 None CNR1, CNR2, OPRD1, OPRK1, OPRM1, PTGS2 4.00624
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK, TNKS 4.00304
[BP] GO:0051051 negative regulation of transport ADORA1, APP, BCL2, CNR1, DRD2, GPR35, HSPA1A, HTR1B, HTR2A, MMP9, OPRK1, OPRM1, PRKCB, PRKCE, PTGS2 4.00304
[BP] GO:0009968 negative regulation of signal transduction AR, BCL2, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PDE3B, PRKCB, PRKCD, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 3.99038
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, OPRD1, PRKCD, PRKCE 3.98102
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.97084
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, KIT, MIF, OPRM1, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2, TRPV1 3.96587
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, POLA1, PRKCB, PRKCE, SMAD3, TRPV1 3.95088
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SENP6, SIGMAR1, SMAD3, SOAT1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.9479
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, PRKCA, PRKCB, PRKCD, TNKS 3.94578
[BP] GO:0051967 None ADORA1, DRD2, HTR1B, HTR2A 3.93368
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.93238
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A, TRPV1 3.92287
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.92287
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PIK3CB, PTPN1, SRC 3.9085
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 3.90096
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, KIT, MMP9, TERT 3.88479
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, DYRK1A, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, OPRK1, PRKCD, PRKCG, PTGS2, PTPN1, PTPRS, TERT, XDH 3.8714
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, OPRK1, PRKCE, SRC, TRPV1 3.8699
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 3.86671
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.85357
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.84454
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.84454
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, DNMT1, DRD2, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, OPRD1, PDE3A, PIK3CB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SENP6, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.84454
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.84333
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, HTR2B, KDR, KIT, MET, MIF, MMP2, MMP9, PDE3A, PGR, PRKCD, PTGS2, PTPRS, RORC, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A 3.84289
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.84221
[BP] GO:2001023 None CNR1, DRD1, DRD2, HTR1B, HTR2A, MET, OPRK1 3.83309
[BP] GO:0051937 None DRD1, SLC22A1, SLC22A2, SLC22A3 3.82352
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, MMP12, PPARA, PRKCD, SMAD3, TEK 3.80733
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.80236
[BP] GO:0002791 None ACHE, ADORA1, CNR1, DRD2, EGFR, HCAR2, HTR2B, HTR2C, MIF, MMP12, OPRM1, PRKCA, PRKCE, SRC 3.80226
[BP] GO:0071502 None HTR1B, HTR2B, TRPV1 3.77095
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.77095
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PRKCA, PRKCB, PTGS2, TEK, TERT 3.7302
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 3.70948
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, DRD2, MIF, PPARA, PRKCD, PTPRS, SMAD3, TEK 3.70568
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, KDR, MET, MIF, OPRM1, PRKCA, PTGS2, SMAD3 3.70568
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, OPRD1, OPRM1, PDE3A, SMAD3, SRC, TRPV1 3.70568
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 3.68178
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK 3.67817
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 3.65881
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TERT, TNKS 3.62342
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.62342
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.59442
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 3.57626
[BP] GO:0060402 None DRD2, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.57626
[BP] GO:0006855 None ABCB1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.57626
[BP] GO:1900542 None DRD1, DRD2, ESRRB, HTR1B, HTR1E, HTR2A, INSR, OPRM1, PPARA, PRKCA 3.57565
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGS1, PTGS2 3.56999
[BP] GO:0055065 metal ion homeostasis APP, BCL2, DRD1, DRD2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.56122
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, OPRD1, PIK3CA, PTGS2 3.55063
[BP] GO:0030534 None APP, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 3.53672
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, DRD1, EGFR, ESR1, KIT, OPRK1, OPRM1, PGR, PTGS2, SRC 3.51663
[BP] GO:0014821 None DRD1, DRD2, HTR1D, HTR2B 3.50921
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.50008
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.50008
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, AKR1C3, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, EGFR, F10, FABP3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, MIF, MMP12, MMP9, OPRD1, OPRM1, PPARA, PRKCB, PRKCD, PRKCE, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SOAT1, SOAT2, SRC, TERT, TNKS, TRPV1, XDH 3.49727
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.48323
[BP] GO:0006140 None DRD1, DRD2, ESRRB, HTR1B, HTR1E, HTR2A, INSR, OPRM1, PPARA, PRKCA 3.47592
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA, TERT 3.45638
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.45269
[BP] GO:0045913 None ESRRB, HTR2A, INSR, PPARA, PRKCE, SRC 3.43887
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CNR1, CSNK2A1, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, OPRM1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT 3.42985
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, OPRD1, PDE3A, SMAD3, SRC, TRPV1 3.42006
[BP] GO:0015893 None ABCB1, CA2, DRD1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.37669
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.37669
[BP] GO:0031644 None ADORA1, GPR35, HTR2C, OPRD1, OPRK1, OPRM1 3.3722
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.3694
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.3694
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, OPRM1, PTGS2, SRC, TRPV1, TYR 3.35332
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, EGFR, HSPA1A, INSR, MIF, PDE3A, PRKCE, SENP6, TERT, TNKS 3.34757
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, AKR1C3, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, EGFR, ESR1, F10, FABP3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, MIF, MMP12, MMP9, OPRD1, OPRM1, PPARA, PRKCB, PRKCD, PRKCE, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 3.34658
[BP] GO:1900543 None DRD2, HTR1B, HTR1E, OPRM1, PPARA, PRKCA 3.34402
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, DRD1, HTR1A, HTR2C, KIT, MIF, OPRK1, OPRM1, PIK3CA, PIK3CB, POLB, PRKCD, PTGS1, PTGS2, SRC, TRPV1 3.34391
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 3.34079
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.33087
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PIK3CB, PRKCD, PTPN1, SRC 3.32655
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 3.31438
[BP] GO:0045980 None DRD2, HTR1B, HTR1E, OPRM1, PPARA, PRKCA 3.31438
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.28841
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.28841
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC 3.28841
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT 3.26937
[BP] GO:0015844 None DRD1, SLC22A1, SLC22A2, SLC22A3 3.26076
[BP] GO:0071383 None AKR1C3, AR, EGFR, FLT3, NR3C1, SRC 3.25185
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TERT 3.23504
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B, TERT 3.23504
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TERT, TNKS, TOP2A 3.23459
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.22474
[BP] GO:0051282 None DRD1, DRD2, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.21672
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 3.19657
[BP] GO:0045934 None APEX1, AR, AURKB, DNMT1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR1B, HTR1E, MMP12, NR3C1, OPRM1, PPARA, PRKCA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1 3.19657
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.19441
[BP] GO:0060401 None DRD2, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.19401
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, OPRD1, OPRM1, POLA1, POLB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1 3.18978
[BP] GO:0042698 ovulation cycle AXL, EGFR, OPRK1, OPRM1 3.18969
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 3.18969
[BP] GO:0050995 None ADORA1, CNR1, HCAR2, PDE3B 3.18969
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SRC 3.18588
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, AKR1C3, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, F10, FABP3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, MIF, MMP12, MMP9, OPRD1, OPRM1, PPARA, PRKCB, PRKCD, PRKCE, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SOAT1, SOAT2, SRC, TNKS, TRPV1, XDH 3.18376
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PRKCD, SMAD3, TEK 3.17859
[BP] GO:0070201 None ACHE, APP, BCL2, CNR1, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, OPRM1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.17859
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PDE3B, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 3.16865
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PPARA, PRKCD, PTGS2, SMAD3, TEK 3.15397
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC, TERT 3.15335
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 3.14146
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A, TYR 3.14146
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.11564
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.11564
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.11564
[BP] GO:0050433 None CNR1, DRD2, HTR1B, HTR2A, OPRK1 3.11564
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.11564
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, KIT, SRC 3.10342
[BP] GO:0050678 None AR, EGFR, F3, HTR2B, KDR, MMP12, PGR, PRKCA, SMAD3, TEK, XDH 3.10118
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIK3CB, SRC, XDH 3.09629
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, KIT, PDE3B, PRKCA, PRKCB, PTGS2, TEK, TERT, XDH 3.09076
[BP] GO:0030815 None DRD2, HTR1B, HTR1E, OPRM1, PRKCA 3.07461
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CNR1, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.07122
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, PRKCE, SRC 3.05768
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.05246
[BP] GO:0042391 None ADORA1, APP, BCL2, CNR1, CNR2, DRD1, GPR35, KDR, OPRD1, OPRM1, SRC, TRPV1 3.03902
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, DRD2, F10, F3, MET, OPRK1, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 3.03902
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.03543
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, MIF, PRKCD 3.032
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CNR1, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.02853
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, OPRK1, OPRM1, PTGS2, SRC 3.02007
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 3.0147
[BP] GO:0030800 None DRD2, HTR1B, HTR1E, OPRM1, PRKCA 2.99887
[BP] GO:0072523 None AOX1, PDE10A, PDE3A, PDE3B, XDH 2.99887
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PTGS2, SRC, TEK, TUBB3 2.99535
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, OPRM1, PTGS2, SRC, TRPV1, TYR 2.99535
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DRD2, DUSP3, ESR1, HSPA1A, KIT, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, PTPRS, SMAD3, SRC 2.9914
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.97105
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 2.97
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 2.96874
[BP] GO:0051223 None ACHE, APP, CNR1, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, OPRM1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.94087
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, CNR1, ESRRB, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 2.93471
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.93283
[BP] GO:0006693 None AKR1C3, MIF, PTGS1, PTGS2 2.93283
[BP] GO:0006692 None AKR1C3, MIF, PTGS1, PTGS2 2.93283
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCE, SMAD3, TRPV1 2.93283
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 2.93148
[BP] GO:0010676 None ESRRB, INSR, PPARA, PRKCE, SRC 2.93148
[BP] GO:0050679 None AR, EGFR, F3, HTR2B, KDR, MMP12, PRKCA, TEK 2.93034
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2, TERT 2.92099
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NR3C1, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SENP6, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.8947
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PIK3CB, PTPN1, SRC 2.89099
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, PRKCE, SRC 2.88248
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PRKCD, PTGS2, SMAD3, SRC, TERT 2.88248
[BP] GO:0046683 response to organophosphorus APEX1, APP, PDE3A, PTGS2, TEK, TRPV1, TYR 2.88248
[BP] GO:0007626 None APP, DRD1, DRD2, HTR2C, OPRD1, OPRK1, OPRM1, PRKCE 2.86662
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, OPRD1, PIK3CA, PTGS2 2.86269
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, HTR2C, PRKCG 2.86067
[BP] GO:0009889 regulation of biosynthetic process ADORA3, AKR1C3, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, NR3C1, NR3C2, OPRD1, OPRM1, PGR, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PTGS2, RORC, SMAD3, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 2.85449
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, EGFR, KIT, OPRK1, OPRM1, POLB, PTGS2, TYR 2.84719
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, OPRK1, PRKCE, SRC 2.84301
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, EGFR, ESR1, FLT3, NR3C1, OPRK1, PRKCE, RORC, SRC 2.84301
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC 2.83773
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 2.83773
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.83773
[BP] GO:0050708 None ACHE, CNR1, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, OPRM1, PRKCA, PRKCE, SRC 2.832
[BP] GO:0009187 None HTR2B, HTR2C, PDE10A, PDE3A, PDE3B 2.82953
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B, TERT 2.82953
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, DRD1, DRD2, HTR1A 2.82543
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, MIF, PIK3CB 2.82185
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, OPRK1, OPRM1, PTGS2, SRC 2.8149
[BP] GO:0050877 None ADORA1, APP, CNR1, CNR2, CYP1B1, DRD1, DRD2, EGFR, HTR2A, INSR, KIT, OPRD1, OPRK1, OPRM1, PRKCG, PTGS2, TRPV1, TYR 2.78199
[BP] GO:0007612 None APP, DRD1, DRD2, INSR, KIT, OPRK1, PTGS2 2.77184
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGS1, PTGS2 2.76358
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 2.76002
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.75733
[BP] GO:0032409 None ABCB1, APP, BCL2, DRD2, GPR35, MMP9, OPRM1, PRKCD, PRKCE 2.75733
[BP] GO:0007208 None HTR2A, HTR2C 2.75733
[BP] GO:0031635 None OPRK1, OPRM1 2.75733
[BP] GO:0016488 None AKR1B10, AKR1C3 2.75733
[BP] GO:0016487 None AKR1B10, AKR1C3 2.75733
[BP] GO:0035408 None PRKCA, PRKCB 2.75733
[BP] GO:0016107 None AKR1B10, AKR1C3 2.75733
[BP] GO:0009115 None AOX1, XDH 2.75733
[BP] GO:0006714 None AKR1B10, AKR1C3 2.75733
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.75733
[BP] GO:0030258 lipid modification CYP1A1, CYP3A4, EGFR, KIT, MET, PIK3CA, PIK3CB, SOAT1, SOAT2 2.75172
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 2.74898
[BP] GO:0032868 None FABP3, HSD11B2, INSR, OPRK1, PDE3B, PPARA, SRC 2.73263
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1, PTGS2 2.73263
[BP] GO:0002031 None DRD2, HTR1B, HTR2B 2.73263
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.73263
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.73263
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, AKR1C3, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KIT, MET, MMP12, NR3C1, NR3C2, OPRD1, OPRM1, PGR, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PTGS2, RORC, SMAD3, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 2.73166
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, HSPA1A, HTR1B, HTR1E, HTR2A, IGF1R, INSR, KIT, MET, MMP12, NR3C1, NR3C2, OPRD1, OPRM1, PGR, PIK3CA, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 2.73134
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 2.73134
[BP] GO:0002209 None BCL2, DRD1, HTR1A, HTR2C 2.73134
[BP] GO:0001662 None BCL2, DRD1, HTR1A, HTR2C 2.73134
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.73134
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CNR1, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.72606
[BP] GO:0003014 None ADORA1, AKR1B1, AKR1C3, BCL2, DRD2, HSD11B2 2.71904
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SENP6, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.71904
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 2.71904
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 2.71904
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.71904
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.69855
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR, PDE3A 2.69691
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CNR1, CYP1A1, EGFR, PTGS2, TRPV1, TYR 2.68444
[BP] GO:0042220 None CNR1, DRD2, HTR1B, OPRM1 2.68225
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 2.68225
[BP] GO:0042752 None ADORA1, DRD2, PPARA, PRKCG, RORC, TOP2A 2.67475
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 2.65457
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 2.65457
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, EGFR, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.64204
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 2.63194
[BP] GO:0042596 None BCL2, DRD1, HTR1A, HTR2C 2.63194
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MIF, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT 2.63194
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.63194
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.63194
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.63194
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.63194
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 2.62813
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PDE3A, PTGS2, TEK, TRPV1, TYR 2.62355
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AR, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MIF, MMP12, MMP9, NR3C1, OPRD1, PGR, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.61972
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SENP6, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.61604
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SENP6, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.61604
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.61604
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.61604
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.61604
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.61604
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PDE3B, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 2.61269
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.59217
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.59217
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 2.57462
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, KIT, OPRD1, PIM1, PRKCB 2.57462
[BP] GO:0051052 regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PIK3CA, PRKCD, PRKCG, SRC, TNKS, TNKS2 2.57462
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 2.57396
[BP] GO:0009266 None ADORA1, HSPA1A, HTR1B, HTR2A, HTR2B, PTGS2, TRPV1 2.56181
[BP] GO:0071456 cellular response to hypoxia BCL2, OPRD1, PRKCE, PTGS2, SRC, TERT 2.55328
[BP] GO:0051930 None ADORA1, OPRD1, OPRK1, OPRM1 2.54551
[BP] GO:0051931 None ADORA1, OPRD1, OPRK1, OPRM1 2.54551
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.53853
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.53853
[BP] GO:0001516 None MIF, PTGS1, PTGS2 2.53853
[BP] GO:0046457 None MIF, PTGS1, PTGS2 2.53853
[BP] GO:0007613 None CNR1, DRD1, DRD2, HTR2A, INSR, PTGS2 2.53483
[BP] GO:0003012 None ADORA1, DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, TRPV1 2.52198
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9, TRPV1 2.51395
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 2.51283
[BP] GO:0045595 regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CNR1, DRD2, EGFR, ESRRA, ESRRB, HTR2A, HTR2C, KDR, KIT, OPRM1, PDE3A, PPARA, PRKCA, PRKCB, PTGS2, PTPRS, RORC, SMAD3, TERT, TRPV1, XDH 2.50961
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, PDE3B, PRKCD, SRC 2.49059
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, PIK3CA, TNKS2 2.48976
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 2.48976
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, INSR, KIT 2.47354
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.45441
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.4465
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.4465
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.43691
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 2.43691
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1 2.43586
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 2.42641
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CNR1, CNR2, CYP19A1, DRD2, DUSP3, MIF, MMP12, PTPRS 2.42166
[BP] GO:0032467 None AURKB, CDC25B, DRD2, PRKCE 2.41736
[BP] GO:0036294 cellular response to decreased oxygen levels BCL2, OPRD1, PRKCE, PTGS2, SRC, TERT 2.41736
[BP] GO:0006936 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, TRPV1 2.41736
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, INSR, PRKCE, TERT 2.41576
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 2.40466
[BP] GO:0008306 None APP, DRD1, DRD2, KIT, OPRK1 2.38314
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.37618
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, HSPA1A, HTR2B, HTR2C, KIT, MET, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PTGS2, XDH 2.37618
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.36676
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.36676
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.36676
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 2.36676
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.36676
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, DRD2, PIK3CB, PRKCG, PTPN1, SRC 2.36676
[BP] GO:0034435 None SOAT1, SOAT2 2.36676
[BP] GO:0060748 None AR, PGR 2.36676
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.36676
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.36676
[BP] GO:0034433 None SOAT1, SOAT2 2.36676
[BP] GO:0034434 None SOAT1, SOAT2 2.36676
[BP] GO:0046110 None AOX1, XDH 2.36676
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.36676
[BP] GO:0033602 None CNR1, DRD2 2.36676
[BP] GO:0016095 None AKR1B10, AKR1C3 2.36676
[BP] GO:0071702 None ABCB1, ADORA1, AKR1C3, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, MMP12, OPRD1, PPARA, PRKCB, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SOAT1, SOAT2, TNKS, TRPV1 2.35336
[BP] GO:0038128 None EGFR, PIK3CA, PRKCA, SRC 2.35029
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 2.35029
[BP] GO:0045597 positive regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CNR1, DRD2, HTR2A, HTR2C, KDR, KIT, OPRM1, PDE3A, PRKCA, PTGS2, SMAD3, TERT 2.34895
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.34466
[BP] GO:0030814 None DRD1, DRD2, HTR1B, HTR1E, OPRM1, PRKCA 2.33706
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, POLB, TEK, TYR 2.3199
[BP] GO:0046890 None AKR1C3, FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 2.3199
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, EGFR, KIT, PTGS2, TYR 2.31468
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.31468
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.30228
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.30228
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.30228
[BP] GO:0070920 None EGFR, ESR1, TERT 2.30228
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.30228
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.30228
[BP] GO:0040008 regulation of growth APP, AR, BCL2, CSNK2A1, DRD2, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, PTPRS, SMAD3, TNKS2 2.29748
[BP] GO:0010959 None ADORA1, BCL2, DRD1, DRD2, GPR35, HTR2A, OPRD1, OPRK1, PRKCE, PTGS2 2.27965
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, PGR, SRC 2.27437
[BP] GO:0022898 None ABCB1, APP, BCL2, DRD2, GPR35, MMP9, OPRM1, PRKCE 2.26346
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, F10, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SENP6, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.25782
[BP] GO:0042060 None ALOX15, EGFR, OPRM1, PPARA, SMAD3 2.25054
[BP] GO:0010675 None ESRRB, INSR, PPARA, PRKCE, RORC, SRC 2.24937
[BP] GO:0045776 None ADORA1, CNR1, DRD2, PPARA 2.23893
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, HTR2A, KIT, MIF, PTPN1, SRC 2.23671
[BP] GO:0043467 regulation of generation of precursor metabolites and energy ESRRB, HTR2A, INSR, OPRK1, PIK3CA, PPARA 2.23166
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.22955
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.22955
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B 2.22955
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GLO1, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, RORC, SENP6, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.2272
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, HTR2A, INSR, PPARA, PRKCE, RORC, SRC 2.22542
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, XDH 2.20524
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.20524
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, HTR5A, PTGS2 2.19907
[BP] GO:0045765 regulation of angiogenesis CYP1B1, F3, KDR, PDE3B, PRKCA, PRKCB, PTGS2, TEK, TERT 2.19863
[BP] GO:0019932 second-messenger-mediated signaling DRD1, DRD2, EGFR, HTR2B, HTR5A, KDR, OPRM1, PDE3A 2.18582
[BP] GO:0070542 None AKR1C3, FABP3, PRKCE, PTGS2, SRC 2.18409
[BP] GO:0045833 None ADORA1, AKR1C3, CNR1, HCAR2, PDE3B 2.18409
[BP] GO:1901570 None ALOX15, ALOX5, MIF, PTGS1, PTGS2 2.18409
[BP] GO:0034762 None ABCB1, APP, BCL2, CA2, DRD1, DRD2, GPR35, MMP9, OPRK1, OPRM1, PRKCE 2.1779
[BP] GO:0030818 None DRD2, HTR1B, OPRM1, PRKCA 2.17132
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A 2.16404
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.16404
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.16404
[BP] GO:0032095 None OPRM1, PPARA, PRKCG 2.16404
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.16404
[BP] GO:0071453 cellular response to oxygen levels BCL2, OPRD1, PRKCE, PTGS2, SRC, TERT 2.15136
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF, PIK3CB 2.14068
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.14068
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.14068
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, ESRRB, HSPA1A, HTR2A, INSR, KDR, PIK3CB, PPARA, PRKCD, PRKCE, PTPN1 2.13466
[BP] GO:0006816 None DRD2, HTR2A, HTR2B, HTR2C, OPRM1, PRKCB, PRKCE, TRPV1 2.12204
[BP] GO:0015850 None DRD1, SLC22A1, SLC22A2, SLC22A3, SOAT1, SOAT2 2.11944
[BP] GO:0001816 cytokine production APP, FABP4, KIT, PRKCD, PTGS2 2.11944
[BP] GO:0009605 response to external stimulus ADORA1, AKR1C3, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HSD11B2, HTR2A, KIT, MMP12, OPRK1, OPRM1, PRKCD, PTGS2, SMAD3, SRC, TRPV1, TYR 2.11614
[BP] GO:1901374 None SLC22A1, SLC22A2 2.11284
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.11284
[BP] GO:0070213 None TNKS, TNKS2 2.11284
[BP] GO:0006145 None AOX1, XDH 2.11284
[BP] GO:0038171 None CNR1, CNR2 2.11284
[BP] GO:0015874 None SLC22A1, SLC22A2 2.11284
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.11284
[BP] GO:0014827 None HTR1D, HTR2B 2.11284
[BP] GO:0030803 None DRD2, HTR1B, OPRM1, PRKCA 2.1128
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, ESR2, HSPA1A, KIT, OPRD1, PRKCB 2.10786
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.10771
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.10771
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.10771
[BP] GO:0051781 None AURKB, CDC25B, DRD2, HTR2B, PRKCE 2.10676
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.10676
[BP] GO:0060191 regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 2.0839
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.0839
[BP] GO:0048638 regulation of developmental growth APP, AR, BCL2, DRD2, INSR, PIK3CA, PIM1, PTPRS, TNKS2 2.078
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, HSPA1A, PDE10A, PDE3A, PDE3B, XDH 2.07728
[BP] GO:0070588 None DRD2, HTR2A, HTR2B, HTR2C, OPRM1, PRKCE, TRPV1 2.06543
[BP] GO:0001936 None F3, HTR2B, KDR, PRKCA, TEK, XDH 2.06451
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.06451
[BP] GO:0001938 None F3, HTR2B, KDR, PRKCA, TEK 2.06451
[BP] GO:0008542 None APP, DRD1, DRD2, KIT 2.05077
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, F3, INSR, KDR, KIT, OPRM1, PDE3B, PIM1, PRKCA, PRKCB, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, XDH 2.04864
[BP] GO:0051341 None CNR1, CNR2, EGFR, HTR2B, TERT 2.02145
[BP] GO:1900372 None DRD2, HTR1B, OPRM1, PRKCA 2.0209
[BP] GO:2000351 None AKR1C3, KDR, TEK, TERT 2.0209
[BP] GO:0030809 None DRD2, HTR1B, OPRM1, PRKCA 2.0209
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.0209
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CYP1B1, DRD2, FABP3, HSPA1A, OPRM1, PTGS2, SMAD3, TERT, XDH 2.02049
[BP] GO:0007623 circadian rhythm DRD2, DYRK1A, EGFR, HTR7, PPARA, RORC 2.01978
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, CNR1, CNR2, DRD1, DRD2, F10, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PTPRS, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 10.5091
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, DRD1, DRD2, EGFR, ESR1, F10, F3, FLT3, GLO1, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP2, OPRD1, OPRK1, OPRM1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TERT, TRPV1 9.62022
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP2, NR3C2, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, TYR 9.40238
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CNR1, CNR2, DRD1, DRD2, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PTPRS, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 9.1804
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CNR1, CNR2, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, OPRD1, OPRK1, OPRM1, PRKCG, PTGS2, PTPRS, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SRC, TEK, TRPV1 8.34446
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR3C2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIK3CA, PIK3CB, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SOAT1, SOAT2, SRC, TEK, TRPV1, TYR 6.64203
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, HSPA1A, HTR5A, KDR, OPRM1, PDE3B, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SIGMAR1, SOAT1, SOAT2, XDH 4.47735
[CC] GO:0045121 membrane raft APP, BACE1, CNR1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, PTGS2, SRC, TEK 4.23865
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SENP6, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 4.22777
[CC] GO:0098857 membrane microdomain APP, BACE1, CNR1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, PTGS2, SRC, TEK 4.214
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR4, HTR5A, INSR, KDR, KIT, MIF, MMP2, MMP9, NQO2, NR3C1, NR3C2, OPRM1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, SENP6, SIGMAR1, SMAD3, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.93238
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, F10, FLT3, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTGS1, PTGS2, PTPN1, SIGMAR1, SOAT1, SOAT2 3.88809
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, CNR1, DRD1, DRD2, EGFR, HTR2A, INSR, MET, OPRD1, OPRM1, PRKCG, PTGS2, SIGMAR1, SLC22A1, SRC, TEK, TRPV1 3.7292
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTGS1, PTGS2, SIGMAR1, SOAT1, SOAT2 3.58843
[CC] GO:0098589 membrane region APP, BACE1, CNR1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, PTGS2, SRC, TEK 3.50008
[CC] GO:0031224 None ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA4, CA9, CNR1, CNR2, CYP3A4, DRD1, DRD2, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTPRS, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SOAT1, SOAT2, TEK, TRPV1, TYR 3.43181
[CC] GO:0032589 None ADORA1, INSR, OPRD1, OPRM1, TRPV1 3.3694
[CC] GO:0043005 None ADORA1, APP, BACE1, CA2, CNR1, CNR2, DRD2, HTR2A, HTR2B, HTR5A, OPRD1, OPRK1, OPRM1, PRKCG, PTGS2, PTPRS, SRC, TUBB3 3.3694
[CC] GO:0043204 None CNR2, DRD2, HTR5A, OPRK1, OPRM1, PDE10A, PTPRS 3.17859
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, HTR2A, HTR4, HTR5A, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, OPRD1, OPRM1, PDE3B, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SIGMAR1, SLC22A2, SLC47A1, SMAD3, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.96874
[CC] GO:0097458 None ADORA1, APP, BACE1, CA2, CNR1, CNR2, DRD2, HTR2A, HTR2B, HTR5A, INSR, OPRD1, OPRK1, OPRM1, PDE10A, PRKCG, PTGS1, PTGS2, PTPRS, SIGMAR1, SLC22A2, SRC, TRPV1, TUBB3 2.93036
[CC] GO:0120025 None ADORA1, AKR1B1, APP, BACE1, CA2, CNR1, CNR2, DRD1, DRD2, HTR2A, HTR2B, HTR5A, HTR6, OPRD1, OPRK1, OPRM1, PIK3CA, PRKCG, PTGS2, PTPRS, SRC, TEK, TUBB3 2.9206
[CC] GO:0016021 None ABCB1, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA9, CNR1, CNR2, CYP3A4, DRD1, DRD2, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTPRS, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SOAT1, SOAT2, TEK, TRPV1, TYR 2.81319
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, INSR, OPRD1, OPRM1, SRC, TRPV1 2.63194
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, BACE1, CA2, CNR1, CNR2, DRD1, DRD2, HTR2A, HTR2B, HTR5A, HTR6, OPRD1, OPRK1, OPRM1, PIK3CA, PRKCG, PTGS2, PTPRS, SRC, TEK, TUBB3 2.61583
[CC] GO:0030424 None APP, BACE1, CA2, CNR1, DRD2, HTR2A, OPRM1, PTPRS, TUBB3 2.60039
[CC] GO:0032590 None INSR, OPRD1, OPRM1 2.4465
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TNKS2, TYR 2.33747
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, HTR2A, HTR4, HTR5A, HTR6, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, OPRD1, OPRM1, PDE3B, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SIGMAR1, SLC22A2, SLC47A1, SMAD3, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.22409
[CC] GO:0031982 None ABCB1, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AXL, BACE1, CA1, CA2, CA4, CA6, CBR1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, GLO1, HSPA1A, HTR2A, HTR4, INSR, KDR, KIT, MIF, MMP9, NQO2, OPRD1, OPRM1, PRKCA, PRKCB, PRKCD, PTGS1, PTPN1, PTPRS, SIGMAR1, SLC22A2, SLC47A1, SRC, TUBB3, TYR 2.16909
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, SLC22A1, TEK 2.078
[CC] GO:0044456 None ACHE, ADORA1, APP, CNR1, DRD2, OPRD1, OPRK1, OPRM1, PRKCG, PTPRS, SIGMAR1, SLC22A2, SRC, TRPV1 2.06451
[CC] GO:0031233 None CA4, F10, F3 2.04796
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 21.7289
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 21.2203
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PDE10A, PDE3A, PDE3B, PGR, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 16.7325
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.0087
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, OPRD1, OPRK1, OPRM1, PGR, PPARA, RORC, SIGMAR1, TEK, TRPV1 14.7015
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 14.6807
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 14.6807
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, F10, F3, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PDE10A, PDE3A, PDE3B, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, SENP6, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 14.5646
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.5646
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.5646
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, OPRM1 13.8221
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, OPRD1, OPRK1, OPRM1, PGR, PPARA, RORC, SIGMAR1, TEK, TRPV1 13.0823
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, OPRD1, OPRK1, OPRM1, PGR, PPARA, PRKCE, RORC, SIGMAR1, SMAD3, TEK, TRPV1 13.0099
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, OPRD1, OPRK1, OPRM1, PGR, PPARA, RORC, SIGMAR1, TEK, TRPV1 12.6166
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS 12.4576
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC, SOAT1, SOAT2 12.3158
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DRD1, DRD2, DYRK1A, EGFR, FLT3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PDE10A, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SIGMAR1, SRC, TEK, TOP2A, TRPV1 12.2134
[MF] GO:0008227 None DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 11.704
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, OPRM1 10.969
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.5091
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 10.3887
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PDE10A, PDE3A, PDE3B, PGR, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 10.373
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.30748
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK, TRPV1 9.20423
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK, TRPV1 9.20423
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.08827
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 8.92367
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 8.80303
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 8.30791
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 7.65909
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PDE10A, PDE3A, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TRPV1, TUBB3, XDH 7.49605
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.25927
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 7.19675
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR 6.98891
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B2, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SOAT1, SOAT2, SRC, XDH 6.93012
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TYR 6.87258
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, XDH 6.85068
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC, SOAT1, SOAT2, TRPV1 6.78998
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 6.78998
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 6.75737
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 6.75737
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 6.48099
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 6.39711
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.35102
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 6.30689
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.17302
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PDE10A, PDE3A, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TUBB3, XDH 6.07214
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.72061
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 5.66879
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TERT 5.65741
[MF] GO:0004930 None ADORA1, ADORA3, CNR1, CNR2, DRD1, DRD2, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, OPRD1, OPRK1, OPRM1, SIGMAR1 5.59017
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.49999
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SOAT1, SOAT2, SRC, TEK, TOP2A, TRPV1, TUBB3, XDH 5.4457
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.29958
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.10601
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 5.05512
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NQO2, NR3C1 4.99931
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HSPA1A, KIT, MET, MIF, NR3C1, PDE3B, PGR, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A 4.96626
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 4.93819
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, TUBB3, XDH 4.91402
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, TUBB3, XDH 4.91041
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPRS, SOAT1, SOAT2, SRC, TEK, TOP2A, TRPV1, TUBB3, XDH 4.75981
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 4.71541
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.18629
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.1356
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.10717
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.08774
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SENP6, SIGMAR1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 4.06329
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.04448
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.00383
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.50008
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.42638
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPRS, SRC, TEK, TOP2A, TRPV1, TUBB3 3.30568
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.23504
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, TUBB3 3.032
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DRD2, DYRK1A, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP9, NQO2, PGR, PTGS2, SLC22A1, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 3.01642
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, TUBB3 2.99263
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE10A, PDE3A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, TUBB3 2.98248
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 2.96874
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 2.96874
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 2.96874
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.75733
[MF] GO:0034736 None SOAT1, SOAT2 2.75733
[MF] GO:0045550 None AKR1B10, AKR1C3 2.75733
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.75733
[MF] GO:0004772 None SOAT1, SOAT2 2.75733
[MF] GO:0003845 None HSD11B1, HSD11B2 2.75733
[MF] GO:0004119 None PDE3A, PDE3B 2.75733
[MF] GO:0008389 None CYP2A13, CYP2A6 2.75733
[MF] GO:0035403 None PRKCA, PRKCB 2.75733
[MF] GO:0071886 None HTR2A, HTR2C 2.75733
[MF] GO:0015238 None ABCB1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.757
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.73263
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SENP6, SRC, TEK 2.71904
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.63194
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, DYRK1A, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 2.61583
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.5171
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.47354
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B 2.4465
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.43586
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 2.42511
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, TUBB3 2.40329
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.36676
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.36676
[MF] GO:0015307 None SLC47A1, SLC47A2 2.36676
[MF] GO:1901375 None SLC22A1, SLC22A2 2.36676
[MF] GO:0047718 None AKR1B10, AKR1C3 2.36676
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.36676
[MF] GO:0004949 None CNR1, CNR2 2.36676
[MF] GO:0005333 None SLC22A1, SLC22A2 2.36676
[MF] GO:0005277 None SLC22A1, SLC22A2 2.36676
[MF] GO:0008513 None SLC22A1, SLC22A2 2.36676
[MF] GO:0004699 None PRKCD, PRKCE 2.36676
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 2.33339
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.32135
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, NR3C1, PDE3B, POLA1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.27066
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, NR3C1, PDE3B, POLA1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.25953
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.22955
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, DUSP3, PDE10A, PDE3A, PDE3B, PTPN1, PTPRS 2.18592
[MF] GO:0033218 amide binding ACHE, BACE1, IGF1R, INSR, NQO2, OPRD1, OPRK1, OPRM1, TUBB3 2.13466
[MF] GO:0005488 binding ABCB1, ACHE, ADORA1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SENP6, SIGMAR1, SLC22A1, SLC22A3, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 2.11944
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.11284
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.11284
[MF] GO:0051425 None APP, INSR 2.11284
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.11284
[MF] GO:0001965 None HTR2A, HTR2B, OPRM1 2.10771
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.04796
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.02145


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, APP, HTR1E, PRKCB, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, PRKCA, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, CYP2D6, ALOX5 20.3294
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, HTR1E, GPR35, HTR1D, HTR2B, HTR1A, OPRK1, HTR1B, HTR2C, OPRM1, TRPV1, HTR2A, NR3C1, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1, DRD1, DRD2 16.2128
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 15.862
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 10.3444
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, HTR2B, HTR2C, PRKCA, PIK3CB, TRPV1, HTR2A 10.0806
cAMP signaling pathway_Homo sapiens_hsa04024 HTR1E, HTR1D, PDE3B, HTR1A, HTR1B, PIK3CB, HTR4, HCAR2, HTR6, PIK3CA, ADORA1, PDE3A, DRD1, DRD2, PPARA 9.901
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, INSR, PRKCA, PIK3CB, EGFR, IGF1R, PIK3CA, CNR1, KIT, KDR, TEK, DRD2, MET 9.5969
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3 8.927
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP3A4, CYP19A1 9.901
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, OPRM1, MMP9, ESR1, EGFR, ESR2, HSPA1A 8.9813
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, TUBB3, HTR2B, HTR2C, PRKCA, HTR2A, DRD1, DRD2, EGFR 9.5042
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, AR, PIK3CA, KIT, BCL2, MET 7.8142
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, EGFR, IGF1R, PIK3CA, KDR, MET 7.8431
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, DNMT1, ABCB1, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, EGFR, CDC25B, PIK3CA, BCL2, PIM1, CYP1B1, MET 7.8142
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, HTR6, HTR7, PRKCB, HTR2B, HTR2C, PRKCA, HTR2A, DRD1, HTR5A, HTR4, EGFR 7.5262
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB, NR3C2 8.6103
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PRKCB, INSR, PRKCA, PIK3CB, EGFR, IGF1R, HTR7, PIK3CA, KIT, KDR, TEK, MET 7.4605
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, INSR, BCL2, PRKCA, TEK, PIK3CB, EGFR, IGF1R 7.7409
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.8142
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PDE3B, ADORA1, PIK3CB, PTGS2, PTGS1 7.4876
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 7.2467
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 7.2215
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB, EGFR 6.7508
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PDE10A, PRKCB, PDE3B, ADORA1, PDE3A, PRKCA, OPRM1, DRD1 7.1344
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.4607
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 6.1271
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.6417
Hepatitis B_Homo sapiens_hsa05161 PRKCG, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 5.4342
Glioma_Homo sapiens_hsa05214 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 5.7883
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA 5.3868
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, PIK3CA, ADORA3, INSR, PRKCE, PDE3B, ADORA1, PDE3A, PIK3CB 4.9751
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, ALOX15, AKR1C3, AKR1B1, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.4808
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, EGFR 4.9751
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 4.8184
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB 4.3649
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2, EGFR 4.3147
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KIT, KDR, BCL2, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 4.1367
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 4.9731
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 4.2221
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET, EGFR 4.561
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 4.2221
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, AKR1C3, PTGS2, PTGS1 4.7476
Prostate cancer_Homo sapiens_hsa05215 AR, PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.9423
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 3.8969
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 3.819
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PDE3B, PGR, PIK3CB, CDC25B, IGF1R 3.7503
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 2.9751
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.0794
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, KIT, PRKCA, PIK3CB, EGFR 2.9115
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, KIT, PRKCA, TYR 2.8027
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.7503
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 3.4324
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 3.8336
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.4113
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.8027
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.8292
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 3.6243
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, CNR1, PRKCA, PTGS2 2.7897
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 2.4203
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP3A4 3.4837
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 2.529
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.4537
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 2.5025
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 3.6002
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.1484
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, PIK3CB 4.1634
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.1891
Phagosome_Homo sapiens_hsa04145 TUBB3 0.1891
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA, DRD1, DRD2 2.3977
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.3274
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.2203
Axon guidance_Homo sapiens_hsa04360 MET 0.2326
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PDE3B, PIK3CB 2.2827
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.2577
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 2.2577
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.2851
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3133
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.0928
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.4445
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.4717
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.4439
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB, HSPA1A 1.9205
Purine metabolism_Homo sapiens_hsa00230 POLA1, PDE10A, PDE3B, PDE3A, XDH 1.9147
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.4725
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3313
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.5527
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.3475
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 1.8153
Peroxisome_Homo sapiens_hsa04146 XDH 0.3489
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 1.9205
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 1.7215
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.5931
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 2.434
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 2.5832
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.6253
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.3711
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.2946
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 1.7951
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 1.8111
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA, DRD1 2.565
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.3274
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.71
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4008
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 1.7749
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 2.7201
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.3333
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.1269
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.7199
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.1437
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3, PIK3CA, TERT, PIK3CB 1.367
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB 1.173
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B, PPARA 0.7371
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.0471
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 1.5678
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.5429
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.3333
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 2.6728
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.3776
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.1508
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.2577
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 1.6826
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.529
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 1.7038
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.1157
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.2276
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, SLC22A1, CYP3A4 2.495
Shigellosis_Homo sapiens_hsa05131 SRC 0.4238
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.1696
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.815
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.2411
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.828
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.3333
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.4725
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 1.4214
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.9
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.4878
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 0.9519
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.4949
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.4949
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.0794
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 1.533
Malaria_Homo sapiens_hsa05144 MET 0.5042
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 0.9694
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 1.6868
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 1.6868
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5091
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 1.7506
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 1.7739
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 1.7739
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 1.7077
Renin secretion_Homo sapiens_hsa04924 PDE3B, ADORA1, PDE3A 1.7951
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5361
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.5303
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.0324
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.7506
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.0999
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.0131
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.5666
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3, PRKCA 1.1475
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.3391
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6094
DNA replication_Homo sapiens_hsa03030 POLA1 0.6014
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6509
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.2279
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.6968
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.1625
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.145
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6714
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.4203
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.706
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6609
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.6968
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.6012
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.4203
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5715
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.533
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.5114
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4475
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.8601
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7587
Steroid biosynthesis_Homo sapiens_hsa00100 SOAT1, SOAT2 1.8438
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.934
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.252
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.8184


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)