TCM Prescription: Shuang Huang Lian Capsule



Prescription Description
Prescription IDTCMF427
Pinyin NameShuang Huang Lian Jiao Nang 
Chinese Name双黄连胶囊
English NameShuang Huang Lian Capsule
Function Description感冒
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 7.22744
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TYR, XDH 6.34756
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.91569
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.91569
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, PIM1, PPARA, TYR, XDH 5.66916
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TYR, XDH 5.49018
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.4753
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PPARA, RORC, SRC, TYR 5.44831
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.44831
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.44831
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 5.44831
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TYR 5.44831
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TYR 5.31497
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.29661
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, MET, PPARA, SRC, TNKS, TNKS2, XDH 4.90518
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 4.80449
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PGR, PIM1, SRC, XDH 4.78296
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MMP2, MMP9, PGR, PIM1, PPARA, PTPRS, RORC, SRC, TNKS2, TYR 4.76437
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.52893
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.52389
[BP] GO:0033993 response to lipid AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR 4.52389
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 4.43798
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TYR, XDH 4.38021
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.06447
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PPARA 4.00429
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC 3.99075
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.89914
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 3.78767
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PPARA, PTPRS, SRC, TYR 3.77405
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 3.77405
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.76735
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.76735
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.76735
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, NR3C1, RORC, SRC, TYR 3.76181
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 3.76181
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TYR, XDH 3.76181
[BP] GO:0030522 intracellular receptor signaling pathway AR, NR3C1, PGR, PIM1, PPARA, RORC, SRC 3.74475
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.73584
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APP, AR, AXL, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, RORC, SRC 3.72871
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.71614
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 3.70944
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 3.702
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TYR 3.63767
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.63767
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, KDR, MMP9, PGR, PIM1, PPARA, PTPRS, RORC, SRC, TYR 3.62485
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.62485
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 3.60267
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.51178
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 3.41059
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, FLT3, KDR, MET, PTPN1, SRC, XDH 3.35103
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, XDH 3.33984
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, SRC 3.3326
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA 3.3192
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 3.30877
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.29671
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC 3.29309
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.21028
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.21028
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.21028
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.17888
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.08309
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 3.05345
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 3.03327
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.02556
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, FLT3, NR3C1, RORC, SRC 2.97716
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC 2.97171
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.97171
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR3C1, NR3C2, PGR, PPARA, RORC 2.96613
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AR, AURKB, CDC25B, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.95544
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.9221
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.90813
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.88305
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TYR 2.83818
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 2.83378
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.83378
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 2.7988
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PTPN1, RORC, SRC 2.7988
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.78894
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, KDR, PTPN1, SRC, XDH 2.77257
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, CYP1A1, FLT3, MET, PIM1, SRC, TYR 2.76129
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 2.75539
[BP] GO:0009725 response to hormone AKR1B1, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, NR3C1, PPARA, SRC 2.74077
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.70704
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.69578
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.6941
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.66387
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.63695
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.633
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA 2.60845
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, TYR 2.59661
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 2.54932
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.49823
[BP] GO:0006352 DNA-templated transcription, initiation AR, NR3C1, NR3C2, PGR, PPARA, RORC 2.49823
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.49823
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.49823
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, IGF1R, KDR, PTPN1, SRC, XDH 2.49391
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 2.47724
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.4569
[BP] GO:0060748 None AR, PGR 2.4445
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4445
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.43925
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 2.43925
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9 2.43652
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC, XDH 2.43399
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.41531
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.37515
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.35229
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, CDC25B, FABP3, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.35229
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, CDC25B, FABP3, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.35229
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.31931
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.31471
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.28159
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SRC, TNKS 2.27953
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.27953
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.27953
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.27953
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, CDC25B, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.27953
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, KDR, SRC, TNKS, TNKS2 2.27362
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.25204
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.25204
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 2.25204
[BP] GO:0070213 None TNKS, TNKS2 2.22953
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.22953
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22953
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.21972
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.21972
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.20804
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.20184
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.19308
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC 2.17361
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.16837
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, CDC25B, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.15379
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.14287
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 2.1405
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2 2.1405
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.1405
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, NR3C1, PGR, SRC 2.1405
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.13086
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 2.13086
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.12873
[BP] GO:1901655 None AKR1B1, AR, NR3C1, SRC 2.09106
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.09106
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7 2.07262
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.07114
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, CA1, CA2, CA7, CBR1, CDC25B, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, NR3C1, NR3C2, PGR, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.28302
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 2.2444
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.92721
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.72935
[CC] GO:0099055 None ADORA1, PTPRS 1.6589
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 15.6159
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 10.3179
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 9.0642
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.12177
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, TNKS 7.16108
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 5.31503
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.1146
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, PPARA, RORC 4.94683
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 4.94397
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 4.4821
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.47356
[MF] GO:0005496 steroid binding AR, HSD17B1, NR3C1, NR3C2, PGR, RORC 4.15398
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.89914
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.76104
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.62485
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.62485
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC 3.3326
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.29452
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.20182
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1 3.06051
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.88223
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.83378
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 2.7988
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.73942
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, PGR, PPARA, RORC 2.73904
[MF] GO:0004879 nuclear receptor activity AR, PGR, PPARA, RORC 2.73904
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.72332
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.71474
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.51545
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.41357
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.28159
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.22341
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC 2.1546
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.14447
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.13086
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.02766


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.5518
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.4921
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.4899
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.4002
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0511
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 3.6341
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.6341
Pathways in cancer_Homo sapiens_hsa05200 AR, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 3.1613
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.3017
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3473
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, MMP9, MET, CDC25B 2.9817
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.1613
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8969
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 2.3614
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.9183
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.051
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.9165
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.9165
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.9165
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15 1.838
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7228
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.762
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4278
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2001
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4277
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3992
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4132
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.348
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3366
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.1153
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.348
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3598
Prostate cancer_Homo sapiens_hsa05215 AR, IGF1R 1.1965
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0797
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.189
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, NR3C1 1.0504
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9566
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2709
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.3366
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3 1.1965
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0742
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.8732
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8576
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8674
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8914
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0262
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0303
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9205
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.762
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8225
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.7231
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.838
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5194
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4939
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3122
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5194
Platelet activation_Homo sapiens_hsa04611 SRC 0.476
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4939
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5194
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5166
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5194
Melanogenesis_Homo sapiens_hsa04916 TYR 0.515
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3753
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5194
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5194
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5126
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3639
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.515
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5194
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5817
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4806
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4598
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4062
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4393
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4636
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3742
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.476
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4356
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4571
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3973
Glioma_Homo sapiens_hsa05214 IGF1R 0.5817
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5654
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4571
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5194
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4636
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4571
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4806
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5194
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4062
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5605
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.476
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4182
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4356
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4365
Axon guidance_Homo sapiens_hsa04360 MET 0.4716
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5194
Peroxisome_Homo sapiens_hsa04146 XDH 0.5213
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5817
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3973
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5817
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5706
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5817
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5706
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5817
Shigellosis_Homo sapiens_hsa05131 SRC 0.5817
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6092
Malaria_Homo sapiens_hsa05144 MET 0.6492
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6678
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.7212
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6788
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.751
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.794
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8353
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7997
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8277
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1613


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)