TCM Prescription: Ke Chuan Ointment



Prescription Description
Prescription IDTCMF4231
Pinyin NameKe Chuan Gao
Chinese Name咳喘膏
English NameKe Chuan Ointment
Function Description咳嗽, 喘病, 哮喘
IndicationsDyspnea, Asthma
Disease ICD-11 Category MD11.5 [Dyspnoea, 呼吸困难 ];
CA23 [Asthma, 哮喘 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1090 Brassica juncea 芥子 TCMH1090 ITSAJ4546-14
TCMH661 Euphorbia kansui 甘遂 TCMH661
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH2431 Datura metel 洋金花 TCMH2431 ITSAM3639-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH2585 Cinnamomum camphora 樟脑 TCMH2585 SDH069-14
TCMH2403 NA 盐酸异丙嗪 TCMH2403
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT601 F2 Thrombin Unclassified P00734
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007187 None ADORA1, ADRA1A, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR6, HTR7 16.2964
[BP] GO:0007188 None ADORA1, ADRA1A, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 16.0196
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 15.9975
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.654
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.6969
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, F2, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, KDR, MET, MIF, PPARA, PRKCD, SLC1A1, SRC, XDH 12.1392
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AXL, CA1, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, PRKCD, SIGMAR1, SRC 10.5825
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 10.5825
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 10.5825
[BP] GO:0007200 None ADRA1A, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, GRM5, HTR2A, HTR2B 10.5101
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 10.5101
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 10.5101
[BP] GO:0023052 None ADORA1, ADRA1A, ADRB1, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 9.77811
[BP] GO:0007267 None ADORA1, ADRA1A, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 9.66667
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 9.30929
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 9.30929
[BP] GO:0003018 None ADORA1, ADRA1A, ADRB1, CHRM1, CHRM3, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC 9.19394
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, PPARA, PRKCD, SRC, TYR 9.02787
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, HTR2A 9.02787
[BP] GO:0007154 None ADORA1, ADRA1A, ADRB1, AXL, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 9.01508
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MIF, MMP9, PRKCD, SRC, XDH 9.01508
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRB1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, ESR1, F2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 9.01508
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MIF, MMP9, PRKCD, SRC, XDH 8.98501
[BP] GO:0097746 None ADORA1, ADRA1A, ADRB1, CHRM1, CHRM3, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 8.9687
[BP] GO:0035296 None ADORA1, ADRA1A, ADRB1, CHRM1, CHRM3, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 8.9687
[BP] GO:0050880 None ADORA1, ADRA1A, ADRB1, CHRM1, CHRM3, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 8.67794
[BP] GO:0035150 None ADORA1, ADRA1A, ADRB1, CHRM1, CHRM3, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 8.65096
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP9, PRKCD, SRC, XDH 8.56601
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HTR5A, IGF1R, KDR, MMP2, PPARA, PRKCD, SRC, TYR 8.55449
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 8.51735
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP9, PRKCD, SRC, XDH 8.42125
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, F2, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP2, MMP9, PIM1, SRC, XDH 8.38317
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP2, MMP9, PPARA, PRKCD, SRC, TYR 8.31962
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRB1, AKR1B1, ALOX5, AXL, CACNA1C, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRB, F2, F3, FABP4, GRM1, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SRC, TYR 8.29769
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM5, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, PPARA, SLC1A1 8.19151
[BP] GO:0003013 None ADORA1, ADRA1A, ADRB1, CHRM1, CHRM3, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC 7.96029
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, F2, HTR2A, HTR2B, KDR, SRC 7.89386
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRB1, CHRM5, DRD1, DRD2, DRD3, EGFR, ERBB2, ESRRB, F2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP9, PPARA, PRKCD, SRC, XDH 7.82084
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR2A, HTR2B, MET, SRC 7.82084
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRB1, CHRM5, DRD1, DRD2, DRD3, EGFR, ERBB2, ESRRB, F2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP9, PPARA, PRKCD, SRC, XDH 7.74651
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP9, PRKCD, SRC, XDH 7.37199
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CYP1B1, DRD2, EGFR, ERBB2, F2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MIF, SRC, XDH 7.34558
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CHRM1, CSNK2A1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP2, MMP9, PIM1 7.2566
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 6.94264
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.9222
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.9222
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.9222
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MIF, MMP9, PRKCD, SRC, XDH 6.9222
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SRC, XDH 6.91375
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SLC1A1, SRC, XDH 6.90558
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, F2, HTR2A, HTR2B, KDR, MIF, SRC 6.85819
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, FABP4, GRIK5, GRM1, GRM5, HTR2A, HTR2B, MET 6.83435
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ERBB2, ESR1, FLT3, HTR1A, MET, MIF, PIM1, PRKCD, SRC, TYR 6.78268
[BP] GO:0006939 None ADRA1A, CHRM3, DRD1, DRD2, HTR2A, HTR2B, HTR7 6.68807
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA 6.57266
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, HTR2B, MIF, PIM1, PPARA, TYR, XDH 6.56879
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, GRM5, HTR5A, IGF1R, MMP2, PPARA, PRKCD, SRC 6.55602
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.54081
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRB1, DRD1, DRD2, EGFR, ERBB2, ESRRB, F2, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, PRKCD, SRC, XDH 6.52408
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRB1, DRD1, DRD2, EGFR, ERBB2, ESRRB, F2, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, PRKCD, SRC, XDH 6.52408
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRB1, CACNA1C, CHRM1, CHRM2, CHRM3, DRD2, EGFR, HTR2A, SLC1A1 6.49971
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, PRKCD, SIGMAR1, SRC, TYR 6.40257
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRB1, CACNA1C, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2B, HTR5A, KDR 6.29543
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.11615
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, KDR, PRKCD, SRC 6.09537
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA3, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MIF, MMP2, MMP9, PPARA, PRKCD, SRC, TYR 6.04547
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CACNA1C, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, F3, GRIK5, GRM5, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PPARA, PRKCD, SRC 5.84739
[BP] GO:0050801 ion homeostasis ADRA1A, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, GRM1, GRM5, HTR2A, HTR2B 5.84554
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRB1, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESRRA, F2, F3, FABP4, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, MIF, MMP2, MMP9, PRKCD, SRC, XDH 5.82079
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.71404
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HSD17B1, HSD17B2, HTR1A, HTR2A 5.62569
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, F3, GRM1, HTR2A, HTR2B, KDR, MET, MIF, MMP9, PIM1, PRKCD, SLC1A1, SRC, XDH 5.61982
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, HTR2A, HTR2B, PRKCD, SRC 5.55013
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, CACNA1C, CHRM1, DRD1, DRD2, DRD3, F2, GRM5, HTR1A, HTR2A, MIF, MMP9, PRKCD 5.54667
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRB1, CACNA1C, CHRM1, CHRM2, CHRM3, DRD2, DRD3, EGFR, GRM1, HTR2A, SLC1A1 5.53486
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PRKCD, SRC 5.47128
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, F2, FABP3, FLT3, HTR2A, HTR2B, PPARA, PRKCD, SRC 5.42862
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FLT3, HTR5A, SRC, TYR 5.38645
[BP] GO:0090066 None ADORA1, ADRA1A, ADRB1, CHRM1, CHRM3, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PRKCD 5.35749
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 5.31039
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, F2, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, MIF, MMP9, PPARA, PRKCD, SIGMAR1, SLC1A1, SRC, XDH 5.30829
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.29009
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, GRM1, GRM5, HTR2A, HTR2B 5.2746
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, HTR2A, HTR2B, PPARA, PRKCD, SRC 5.26322
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PRKCD, SRC 5.25255
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HTR5A, PPARA, PRKCD, SRC 5.1427
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, MIF, MMP9, PPARA, PRKCD, SIGMAR1, SLC1A1, SRC, XDH 5.1087
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM3, CHRM5, DRD1, DRD2, DRD3, F2, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, MIF, MMP9, PPARA, PRKCD, SIGMAR1, SLC1A1, SRC, XDH 5.10556
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, DRD2, EGFR, ERBB2, ESRRB, F2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, PRKCD, SRC, XDH 5.09386
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 5.07497
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PRKCD, SRC 5.0603
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, AXL, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, FLT3, HSD17B2, HTR5A, KDR, MMP9, PIM1, PPARA, SIGMAR1, SRC, TYR 5.0603
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCD, SIGMAR1, SRC, XDH 5.05135
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, DRD1, DRD2, EGFR, ERBB2, ESRRB, F2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP9, PPARA, PRKCD, SRC, XDH 5.04318
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PRKCD, SRC 5.0153
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CHRM1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 5.0153
[BP] GO:0003008 None ADORA1, ADRA1A, ADRB1, AKR1B1, CHRM1, CHRM3, CHRM5, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR7, SRC, TYR 4.97433
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PRKCD, SIGMAR1, SRC, XDH 4.97433
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SIGMAR1, SLC1A1, SRC, TYR, XDH 4.93955
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 4.89697
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, GRM1, GRM5, HTR2A, HTR2B 4.85782
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.84157
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, IGF1R, MIF, PRKCD, SRC 4.82629
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, DRD2, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, KDR, MIF, SRC, XDH 4.81566
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRB1, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, HTR2B, IGF1R, MIF, MMP9, PRKCD, SRC, XDH 4.80995
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CACNA1C, CHRM1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, GRIK5, GRM5, HTR1A, HTR2A, HTR2B, MIF, MMP9, PPARA, PRKCD, SRC 4.74775
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, DRD2, EGFR, ERBB2, F2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP2, MMP9, PRKCD, SRC 4.73616
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, DRD2, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, IGF1R, KDR, MIF, PRKCD, SRC, XDH 4.73242
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, HTR5A, SRC, TYR 4.71189
[BP] GO:0001659 None ADORA1, ADRB1, DRD1, DRD2, HTR2A 4.71171
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, DRD2, EGFR, ERBB2, F2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, PRKCD, SRC, XDH 4.68336
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, ADRB1, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, HTR2B, IGF1R, MET, MIF, MMP9, PIM1, PPARA, PRKCD, SRC, XDH 4.66499
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, ERBB2, F3, MET, SRC, XDH 4.66367
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.65306
[BP] GO:0055080 cation homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, GRM1, GRM5, HTR2A, HTR2B 4.65098
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, ESR1, F2, GRM1, GRM5, HTR2A, HTR2B 4.59112
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.59112
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.56435
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.52418
[BP] GO:0033674 positive regulation of kinase activity ADORA1, DRD2, EGFR, ERBB2, F2, FLT3, GRM1, GRM5, HTR2A, HTR2B, MIF, PRKCD, SRC 4.5137
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.50391
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.50391
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.50391
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.4786
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, GRIK5, GRM1, GRM5, HTR2A, HTR2B 4.47409
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HTR2B, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, SIGMAR1, SRC, XDH 4.45851
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.42257
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, DRD1, DRD2, EGFR, ERBB2, F2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP9, PRKCD, SRC, XDH 4.41181
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, GRM1, GRM5, HTR2A, HTR2B 4.40628
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRB1, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PPARA, PRKCD, SRC, XDH 4.3908
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, GRM1, HTR2A, HTR2B, MMP2, PPARA, SRC, TYR 4.38444
[BP] GO:0030003 cellular cation homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, GRM1, GRM5, HTR2A, HTR2B 4.3802
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRB1, AKR1B1, AXL, CACNA1C, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MET, MIF, PRKCD, SRC 4.37355
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRB1, AXL, CA2, CHRM3, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F2, F3, HTR2A, HTR2B, KDR, MET, MIF, MMP9, PIM1, SLC1A1, SRC 4.34464
[BP] GO:1900542 None ADRB1, DRD1, DRD2, DRD3, ESRRB, GRM3, GRM8, HTR2A, PPARA 4.34464
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 4.34224
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F2, F3, FABP4, KDR, MET, MIF, PPARA, PRKCD 4.32846
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.32153
[BP] GO:0055074 calcium ion homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, GRM1, GRM5, HTR2A, HTR2B 4.30133
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, DRD1, DRD2, HTR2A, MET 4.28706
[BP] GO:0006873 cellular ion homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, GRM1, GRM5, HTR2A, HTR2B 4.28358
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, DRD2, EGFR, ERBB2, F2, FLT3, GRM1, GRM5, HTR2A, HTR2B, MIF, PRKCD, SRC 4.26962
[BP] GO:0006140 None ADRB1, DRD1, DRD2, DRD3, ESRRB, GRM3, GRM8, HTR2A, PPARA 4.25844
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, GRM1, GRM5, HTR2A, HTR2B 4.25844
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, EGFR 4.22422
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CA3, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, PRKCD, SRC 4.22004
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, EGFR, ERBB2, F2, PPARA 4.20038
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, HSD17B1, HSD17B2 4.1797
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, ESR1, F2, GRM1, HTR2A, HTR2B 4.16723
[BP] GO:0045776 None ADORA1, ADRB1, DRD2, DRD3, PPARA 4.13772
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, TYR 4.1371
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.10711
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, ADRB1, AURKB, DRD2, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, MET, MIF, MMP9, PRKCD, SRC, XDH 4.09828
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 4.09795
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PPARA, PRKCD, SRC, XDH 4.09731
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, HTR1A, SLC1A1 4.08565
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, DRD2, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2A, HTR2B, MIF, PRKCD, SRC 4.05248
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCD, SRC 4.03575
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP9, PRKCD, SRC 4.02972
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF, PRKCD 4.02907
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, MIF, SRC 3.97455
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CHRM1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, HTR2B, MIF, PRKCD, SRC 3.97455
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, ERBB2, FABP3, FABP4, FUT7, MET, MIF, PPARA 3.97067
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.96618
[BP] GO:0043549 regulation of kinase activity ADORA1, DRD2, EGFR, ERBB2, F2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, MIF, PRKCD, SRC 3.95587
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, EGFR, HTR2A, HTR2B, KDR, MIF, SRC 3.93418
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, EGFR, ERBB2, HTR2A, HTR2B, KDR, MIF, SRC 3.85315
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.84387
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PRKCD, SRC 3.84207
[BP] GO:0055065 metal ion homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, GRM1, GRM5, HTR2A, HTR2B 3.82261
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PRKCD, SRC, TYR 3.80421
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, F2, MIF, PPARA, PRKCD 3.80421
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP2, MMP9, PPARA, PRKCD, SRC, XDH 3.80421
[BP] GO:0019933 None ADRA1A, ADRB1, DRD1, DRD2, DRD3, HTR5A 3.79926
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRB1, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PPARA, PRKCD, SRC, XDH 3.78352
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, HTR7, PPARA, SRC 3.74975
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.74283
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.74283
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 3.7404
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, DRD2, EGFR, ERBB2, F2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, MIF, PRKCD, SRC 3.72151
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, ADRB1, AURKB, DRD2, EGFR, ERBB2, ESR1, F2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, MIF, PRKCD, SRC, XDH 3.69147
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, HTR2A, IGF1R, MET, MIF, MMP9, PRKCD, SRC, XDH 3.69147
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MET, MIF, MMP1, MMP9, PRKCD, SRC 3.67953
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.67953
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.67953
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, HTR2A, IGF1R, MET, MIF, MMP9, PRKCD, SRC, XDH 3.67953
[BP] GO:0019725 cellular homeostasis ADRA1A, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, GRIK5, GRM1, GRM5, HTR2A, HTR2B 3.66577
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF 3.66568
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SIGMAR1, SLC1A1, SRC, XDH 3.65448
[BP] GO:0045859 regulation of protein kinase activity ADORA1, DRD2, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, MIF, PRKCD, SRC 3.65183
[BP] GO:0030817 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 3.64488
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PRKCD, SRC 3.62447
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HTR1A, HTR2A, HTR2B, MIF, SRC 3.62166
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GRM3, GRM8, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCD, SRC, XDH 3.60376
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP9, PRKCD, SRC 3.60222
[BP] GO:0019935 None ADRA1A, ADRB1, DRD1, DRD2, DRD3, HTR5A 3.60222
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, F2 3.55513
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, GRM1, GRM5, HTR2A, HTR2B 3.54704
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.54704
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.54704
[BP] GO:0090087 None ACHE, ADORA1, CA2, CACNA1C, CHRM1, DRD2, DRD3, EGFR, ERBB2, F2, HTR2B, MIF, PRKCD, SRC 3.52959
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF 3.51636
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.51145
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, CSNK2A1, DRD2, EGFR, ERBB2, ESR1, F2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, PRKCD, SRC, XDH 3.50588
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.50481
[BP] GO:0050730 None ADORA1, EGFR, FLT3, GRM5, HTR2A, MIF, PRKCD, SRC 3.50479
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PRKCD, SRC, TYR 3.48593
[BP] GO:0019229 None ADRA1A, CHRM1, CHRM3, EGFR, HTR2A 3.48316
[BP] GO:0042391 None ADORA1, ADRA1A, CACNA1C, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.47882
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, CHRM1, CHRM3, DRD2, F2, F3, MET, PRKCD, XDH 3.47882
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, PRKCD, SRC 3.46703
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, IGF1R, MET, MIF, MMP9, PPARA, PRKCD, SRC, XDH 3.46437
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, DRD2, EGFR, ERBB2, F2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, PRKCD, SRC, XDH 3.45824
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PPARA, PRKCD, SRC, XDH 3.44661
[BP] GO:0008016 None ADORA1, ADORA3, ADRA1A, ADRB1, CACNA1C, CHRM2, DRD2, SLC1A1 3.43704
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, IGF1R, MIF, PRKCD, SRC 3.42945
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.42945
[BP] GO:0071310 cellular response to organic substance AKR1B1, AXL, CYP1A1, CYP1B1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, PRKCD, SRC 3.42945
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MIF, MMP9, PRKCD, SRC, XDH 3.42292
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.41236
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, PRKCD, SRC 3.38672
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.37027
[BP] GO:0060402 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 3.37027
[BP] GO:0051282 None CACNA1C, DRD1, DRD2, F2, HTR2A, HTR2B 3.34833
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 3.34288
[BP] GO:0006940 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM3 3.34288
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HTR1A, HTR2A, HTR2B, MIF, SRC 3.33916
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, ESR1, IGF1R, MET, MIF, MMP9, PRKCD, SRC, XDH 3.33844
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.33197
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HTR2B, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, SRC 3.32436
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, DRD2, EGFR, ERBB2, ESR1, F2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MIF, MMP9, PRKCD, SRC, XDH 3.31045
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling ERBB2, HTR2A, HTR2B, IGF1R 3.30292
[BP] GO:0030814 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 3.29598
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.2826
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.2826
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA1, CA2, CA7, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SIGMAR1, SLC1A1, SRC, XDH 3.27057
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR 3.26524
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.25495
[BP] GO:0030802 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 3.24077
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 3.23776
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, EGFR, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PRKCD, SRC 3.23555
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CA1, CA2, CA7, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SIGMAR1, SRC, XDH 3.23474
[BP] GO:1903524 None ADRA1A, ADRB1, EGFR, HTR2A, SLC1A1 3.20986
[BP] GO:1900543 None DRD2, DRD3, GRM3, GRM8, PPARA 3.1837
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.16402
[BP] GO:0007189 None ADRA1A, ADRB1, DRD1, DRD2, DRD3 3.15796
[BP] GO:0045980 None DRD2, DRD3, GRM3, GRM8, PPARA 3.15796
[BP] GO:0003012 None ADORA1, ADRA1A, CHRM3, DRD1, DRD2, HTR2A, HTR2B, HTR7 3.15295
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SRC, TYR, XDH 3.13894
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, MIF, SRC 3.13894
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 3.07785
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GRM3, GRM8, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCD, SRC, XDH 3.07535
[BP] GO:0050890 None ADORA1, CHRM1, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A 3.06757
[BP] GO:1900371 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 3.06757
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 3.05892
[BP] GO:0060401 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 3.05892
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.05509
[BP] GO:0030808 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 3.05509
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.03509
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, DRD1, DRD2, EGFR, ERBB2, F2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP9, PRKCD, SRC, XDH 3.02238
[BP] GO:0001997 None ADRA1A, ADRB1 2.98899
[BP] GO:0009115 None AOX1, XDH 2.98899
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, PRKCD, SRC 2.96975
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.9624
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.9624
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.9624
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CSNK2A1, DRD1, EGFR, ERBB2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PRKCD, SRC 2.93834
[BP] GO:0051222 positive regulation of protein transport ACHE, CHRM1, DRD2, EGFR, ERBB2, F2, HTR2B, MIF, PRKCD, SRC 2.88141
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HTR2B, MIF, SRC 2.87897
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.86782
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.86782
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.86782
[BP] GO:0030799 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 2.86026
[BP] GO:0060191 regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 2.85009
[BP] GO:0006936 None ADRA1A, CHRM3, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.84031
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PPARA 2.83901
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, HTR2B, MIF, SRC 2.83213
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.80285
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.80285
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.78456
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KDR, MET, MIF, MMP1, MMP2, PIM1, PPARA, PRKCD, SRC, TYR, XDH 2.77664
[BP] GO:0030818 None DRD2, DRD3, GRM3, GRM8 2.76675
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.76675
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.76675
[BP] GO:0008217 None ADORA1, ADRA1A, ADRB1, DRD2, DRD3, PPARA 2.75946
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, HTR1A 2.74569
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, MET, SRC 2.71433
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.71007
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.71007
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.71007
[BP] GO:0030803 None DRD2, DRD3, GRM3, GRM8 2.70229
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF 2.67494
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.6685
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, CHRM1, DRD2, EGFR, ERBB2, F2, HTR2B, MIF, PRKCD, SRC 2.66691
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A, TYR 2.64332
[BP] GO:0030815 None DRD2, DRD3, GRM3, GRM8 2.63552
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, ERBB2, F2, FLT3, IGF1R, KDR, MET, PRKCD, SRC 2.62384
[BP] GO:0002027 None ADRA1A, ADRB1, CACNA1C, DRD2, SLC1A1 2.60654
[BP] GO:1900372 None DRD2, DRD3, GRM3, GRM8 2.60447
[BP] GO:0030809 None DRD2, DRD3, GRM3, GRM8 2.60447
[BP] GO:0006937 None ADORA1, ADRA1A, CACNA1C, CHRM1, CHRM2, CHRM3 2.59301
[BP] GO:0043270 None ADORA1, CHRM1, DRD1, DRD2, F2, MIF, PRKCD 2.58279
[BP] GO:0030800 None DRD2, DRD3, GRM3, GRM8 2.57939
[BP] GO:0099566 None GRM1, GRM5 2.57939
[BP] GO:0001996 None ADRA1A, ADRB1 2.57939
[BP] GO:0046110 None AOX1, XDH 2.57939
[BP] GO:0060160 None DRD2, DRD3 2.57939
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57939
[BP] GO:0003099 None ADRA1A, ADRB1 2.57939
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.57435
[BP] GO:0050877 None ADORA1, CHRM1, CHRM5, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HTR2A, TYR 2.5654
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HTR2A, MET, SRC 2.54266
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HTR2A, MET, SRC 2.54266
[BP] GO:0030260 entry into host cell AXL, EGFR, HTR2A, MET, SRC 2.54266
[BP] GO:0044409 entry into host AXL, EGFR, HTR2A, MET, SRC 2.54266
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, MET, PPARA, PRKCD, SRC 2.52502
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.52452
[BP] GO:0007610 None DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR1A, HTR2A, HTR2B, PPARA 2.52408
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.51524
[BP] GO:0046903 None ALOX5, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, MIF, MMP9, PRKCD, SLC1A1, XDH 2.49924
[BP] GO:0051223 None ACHE, CACNA1C, CHRM1, DRD2, DRD3, EGFR, ERBB2, F2, HTR2B, MIF, PRKCD, SRC 2.49232
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, F2, PPARA, PRKCD 2.47711
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.46917
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CA3, CYP1B1, EGFR, MMP9, PRKCD, SRC 2.45446
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.45446
[BP] GO:0071880 None ADRA1A, ADRB1, DRD2 2.45446
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, HTR2A, MIF, SRC 2.4544
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.44444
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 2.44444
[BP] GO:0051716 cellular response to stimulus AKR1B1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MIF, MMP2, MMP9, PRKCD, SRC 2.44009
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HTR2B, MIF, SRC 2.43317
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD, SRC 2.42937
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AURKB, CA9, CHRM5, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCD, SRC, XDH 2.413
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, DRD2, DRD3, EGFR, HTR2B, MIF, SRC 2.40232
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.40232
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.40232
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, DRD1, EGFR, ERBB2, ESR1, FLT3, GRM5, IGF1R, MMP2, PRKCD, SRC 2.38241
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CYP19A1, DRD2, EGFR, HTR1A, HTR2A 2.35846
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD1, DRD2, DRD3, FABP3, PPARA, SIGMAR1, SLC1A1 2.35826
[BP] GO:0019722 calcium-mediated signaling CACNA1C, EGFR, GRM5, HTR2B, KDR 2.34524
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.345
[BP] GO:0006145 None AOX1, XDH 2.32714
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.32714
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32714
[BP] GO:0006928 movement of cell or subcellular component AXL, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F2, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP9, PRKCD, SRC 2.31965
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, F2, PPARA, PRKCD 2.31721
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AURKB, CA9, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCD, SRC, XDH 2.31581
[BP] GO:0070201 None ACHE, CACNA1C, CHRM1, DRD2, DRD3, EGFR, ERBB2, F2, HTR2B, MIF, PRKCD, SRC 2.31051
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.29664
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.29664
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD 2.29664
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.29664
[BP] GO:0048015 phosphatidylinositol-mediated signaling ERBB2, HTR2A, HTR2B, IGF1R 2.29664
[BP] GO:0010460 None ADRA1A, ADRB1, SLC1A1 2.24669
[BP] GO:0071875 None ADRA1A, ADRB1, DRD2 2.24669
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.24669
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, PRKCD 2.24269
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F2, F3, FABP4, KDR, MET, MIF 2.22384
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, PRKCD 2.22384
[BP] GO:0048017 inositol lipid-mediated signaling ERBB2, HTR2A, HTR2B, IGF1R 2.22384
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ADRB1, AURKB, CA9, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCD, SRC, XDH 2.2123
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3 2.20045
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, HTR5A 2.18335
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 2.16886
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.15479
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.15479
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.15479
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, PRKCD 2.14202
[BP] GO:0021853 None DRD1, DRD2 2.14202
[BP] GO:0046541 None CHRM1, CHRM3 2.14202
[BP] GO:0010641 None F3, SRC 2.14202
[BP] GO:0090325 None DRD2, DRD3 2.14202
[BP] GO:1904936 None DRD1, DRD2 2.14202
[BP] GO:0042321 None ADORA1, DRD2 2.14202
[BP] GO:0010513 None HTR2A, HTR2B 2.14202
[BP] GO:0045913 None ESRRB, HTR2A, PPARA, SRC 2.14012
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.11696
[BP] GO:0045745 None DRD2, DRD3, F2 2.11696
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, PRKCD, SRC 2.11268
[BP] GO:0016310 phosphorylation AURKB, AXL, CSNK2A1, DRD1, EGFR, ERBB2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PRKCD, SRC 2.11075
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, DRD1, EGFR, GRM5, IGF1R, MMP2, PRKCD, SRC 2.09766
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DRD2, EGFR, ESR1, F2, F3, FABP4, IGF1R, MET, MIF, MMP2, PPARA, PRKCD, SRC, XDH 2.08301
[BP] GO:0016572 histone phosphorylation AURKB, DRD1, PRKCD 2.07625
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.07625
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.07625
[BP] GO:0060341 regulation of cellular localization CACNA1C, CHRM1, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, GRIK5, PRKCD, SRC 2.07356
[BP] GO:0032880 regulation of protein localization ACHE, CACNA1C, CHRM1, CSNK2A1, DRD2, DRD3, EGFR, ERBB2, F2, HTR2B, MIF, PRKCD, SRC 2.04351
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, DRD2, EGFR, ERBB2, FABP3, FABP4, MET 2.03904
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, HTR7, PPARA 2.02517
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, TYR, XDH 2.02041
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MIF, MMP9, PRKCD, SRC, XDH 2.00034
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1 11.7286
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1, SRC 11.6084
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, MET, SIGMAR1, SLC1A1, SRC 10.5825
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1 10.5547
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, PRKCD, SLC1A1, SRC 9.39142
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1 6.47471
[CC] GO:0044456 None ACHE, ADORA1, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1, SRC 6.44207
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, PRKCD, SIGMAR1, SLC1A1, SRC, TYR 6.21077
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1, SRC, TYR 6.04547
[CC] GO:0014069 None ADORA1, CACNA1C, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 5.89334
[CC] GO:0099572 None ADORA1, CACNA1C, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 5.89334
[CC] GO:0043005 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, SRC 4.93955
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, SIGMAR1 4.66367
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CHRM1, CHRM2, CHRM3, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC 4.39167
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CA12, CA14, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1, TYR 4.33324
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC 4.1497
[CC] GO:0016021 None ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CA12, CA14, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1, TYR 3.83321
[CC] GO:0097458 None ADORA1, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, SIGMAR1, SRC 3.77869
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, SIGMAR1, SRC 3.54044
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, SIGMAR1, SRC 3.54044
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.42945
[CC] GO:0045202 None ACHE, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2, HTR2B 3.19146
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, ERBB2 3.1837
[CC] GO:0098793 None ADORA1, CHRM1, CHRM2, CHRM3, DRD2, GRIK5 2.53685
[CC] GO:0030425 None CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIK5, GRM1, HTR5A 2.52408
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.44444
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.27225
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.24269
[CC] GO:0044306 None CHRM1, CHRM2, CHRM3, DRD2 2.09766
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 19.9373
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 19.9373
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 19.7273
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 18.312
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 17.9116
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 16.9548
[MF] GO:0008227 None ADRA1A, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 15.9888
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 15.5078
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 15.5078
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.538
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 12.4882
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, TYR, XDH 12.4571
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0993
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SLC1A1, SRC, TYR, XDH 10.5825
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 9.71858
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 9.01508
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.38317
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SLC1A1, TYR, XDH 8.19151
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PRKCD, SIGMAR1, SRC 7.87845
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.26279
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.9222
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.9222
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.9222
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.9222
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.54081
[MF] GO:0042165 neurotransmitter binding ACHE, CHRM3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.47895
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA 6.29543
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.97641
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.30019
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.30019
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, ERBB2, F2, F3, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PRKCD, SRC, TYR, XDH 5.17392
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PRKCD, SRC 5.1427
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.0603
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 4.50391
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.13201
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.00984
[MF] GO:1901338 None ADRB1, DRD1, DRD2, DRD3 3.96618
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.84387
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.84387
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 3.70435
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.51145
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.41236
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.34833
[MF] GO:0046872 metal ion binding ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SLC1A1, TYR, XDH 3.23952
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PRKCD, SRC 3.15745
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC 3.08148
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.05892
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.98899
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.9624
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC 2.92302
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R 2.85009
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 2.83038
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, TYR, XDH 2.74488
[MF] GO:0004935 None ADRA1A, ADRB1, DRD2 2.71007
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 2.67494
[MF] GO:0099583 None GRM1, GRM5 2.57939
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.51524
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.51524
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PRKCD, SRC 2.48278
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.42937
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD17B1, PPARA 2.41709
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.32714
[MF] GO:0004971 None GRIA2, GRIA4 2.32714
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, SRC, XDH 2.21433
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP9, PIM1, PPARA, SRC 2.18978
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PRKCD, SRC 2.17
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.14202
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.11696
[MF] GO:0042802 identical protein binding ACHE, AOX1, CSNK2A1, DRD2, EGFR, ERBB2, ESR1, ESR2, FLT3, GRIK5, IGF1R, KDR, MET, MIF, MMP9, TYR, XDH 2.06798
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AOX1, HSD17B1, HSD17B2, XDH 2.02517


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, HTR2B, ADRB1, HTR2A, ADRA1A, GRM1, GRM3, HTR6, GRM5, HTR7, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, GRIA4, HTR1A, F2, HTR5A 24.9859
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, HTR2B, ADRB1, CACNA1C, HTR2A, HTR5A, ADRA1A, GRM1, EGFR, HTR6, GRM5, HTR7, ERBB2, DRD1 16.9344
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.9333
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA2, HTR6, CHRM1, ADORA1, HTR1A, ADRB1, CACNA1C, DRD1, DRD2, PPARA, GRIA4 9.2858
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2B, ADRB1, HTR2A, DRD1, DRD2, GRM1, EGFR 8.821
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 7.9469
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, HTR2B, HTR1A, CACNA1C, HTR2A, HTR5A 7.9492
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.8167
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, PRKCD, MMP9, ESR1, GRM1, EGFR, ESR2 7.1539
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.9469
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.7997
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.9469
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 5.3425
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, CACNA1C 4.3363
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, CACNA1C, DRD1, DRD2, DRD3, GRIA4 3.9901
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5, F2, EGFR 3.7945
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCD, CACNA1C, EGFR 3.6625
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, GRM1, GRIA4 3.49
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, ERBB2, MMP9, MET, EGFR, IGF1R 3.102
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8139
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, MET, EGFR, IGF1R 3.102
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, EGFR, IGF1R 3.067
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, CACNA1C, DRD1, GRIA4 3.102
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.5348
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 3.102
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.102
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1, EGFR 2.9385
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 2.6745
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C, ADRA1A 2.6836
Taste transduction_Homo sapiens_hsa04742 CHRM3, HTR1A, CACNA1C, GRM1 2.8523
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PRKCD, PIM1, F3 2.5931
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.0381
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCD, HTR2B, HTR2A 2.6302
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.102
MicroRNAs in cancer_Homo sapiens_hsa05206 ERBB2, PIM1, CYP1B1, MMP9, MET, EGFR 2.4012
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, EGFR, IGF1R 2.1713
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, MET, EGFR, IGF1R 2.161
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.2941
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2187
Metabolic pathways_Homo sapiens_hsa01100 FUT7, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, AKR1B1, TYR, CYP19A1, XDH 1.6979
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.845
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.0807
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.161
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0728
Prostate cancer_Homo sapiens_hsa05215 ERBB2, EGFR, IGF1R 1.8573
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.8677
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1149
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.7948
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, EGFR, IGF1R 1.706
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.161
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1 2.1066
Salivary secretion_Homo sapiens_hsa04970 CHRM3, ADRB1, ADRA1A 1.8573
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3511
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, EGFR, IGF1R 1.443
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCD, CACNA1C, ADRA1A 1.5484
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 1.9311
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, CACNA1C, ADRA1A 1.3511
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCD 1.3997
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.3074
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.821
Insulin resistance_Homo sapiens_hsa04931 PRKCD, PPARA 0.9208
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7983
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7762
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8716
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.845
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8716
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8642
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7762
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.7716
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2622
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.261
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2725
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.6527
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.282
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2909
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.731
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0428
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2906
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC, PRKCD 0.6297
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.3022
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR 0.4827
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.0458
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0069
Insulin secretion_Homo sapiens_hsa04911 CHRM3, CACNA1C 1.079
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0576
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3327
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3495
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3605
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.1707
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.135
Platelet activation_Homo sapiens_hsa04611 SRC 0.388
Axon guidance_Homo sapiens_hsa04360 MET 0.3803
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD 0.39
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.388
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4135
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.3924
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.1308
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4411
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4403
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4403
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4403
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCD 0.4495
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2623
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4492
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4488
Pancreatic cancer_Homo sapiens_hsa05212 ERBB2, EGFR 1.2562
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4495
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4544
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4544
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4544
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3074
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4544
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4715
Peroxisome_Homo sapiens_hsa04146 XDH 0.4698
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3432
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.3913
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.3511
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4698
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4817
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5071
Bile secretion_Homo sapiens_hsa04976 CA2 0.5057
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4939
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5256
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5296
Shigellosis_Homo sapiens_hsa05131 SRC 0.5275
Type II diabetes mellitus_Homo sapiens_hsa04930 PRKCD, CACNA1C 1.443
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5528
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5378
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6057
Malaria_Homo sapiens_hsa05144 MET 0.6173
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6254
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5724
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6212
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6297
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7865
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7716
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7627
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7151
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7542
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7762
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7762
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7924
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9682
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7865
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9329
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.102
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3074


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)