TCM Prescription: Wu Ji Bai Feng Granules



Prescription Description
Prescription IDTCMF421
Pinyin NameWu Ji Bai Feng Ke Li 
Chinese Name乌鸡白凤颗粒
English NameWu Ji Bai Feng Granules
Function Description妇女体虚, 月经不调, 经行腹痛
IndicationsAbdominal pain disorder, Irregular menstruation
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2183 Gallus domesticus 乌鸡 TCMH2183
TCMH338 Carapax trionycis 醋鳖甲 TCMH338
TCMH1793 Ootheca mantidis 桑螵蛸 TCMH1793
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH2084 Asparagus cochinchinensis 天冬 TCMH2084 ITSAJ4142-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1663 Semen euryales 芡实 TCMH1663
TCMH1345 Pulvis cornu cervi 鹿角胶 TCMH1345
TCMH1525 Crassostrea gigas 牡蛎 TCMH1525 BCMOL364-12
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH2493 Stellaria dichotoma var. lanceolata 银柴胡 TCMH2493
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH1346 Cornu cervi degelatinatum 鹿角霜 TCMH1346
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 14.4619
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, ESR1, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 12.4709
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, FDPS, FUT7, GBA2, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 12.1039
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 12.0245
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5265
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.8701
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.5951
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 9.64566
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, FABP4, FDPS, FUT7, GBA2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 9.53564
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 9.38883
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 9.14578
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 9.14578
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, NQO2, PTGS1, RORC 9.07365
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTGS2, RORC, SLC6A4, SRC, TYR 8.42258
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KCNH2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 8.41729
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 8.11395
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SRC, TYR 8.07062
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 8.07062
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 7.76023
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.75208
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.35501
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.32478
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 7.03306
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SRC, TYR 6.95818
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 6.93657
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SLC6A4, SRC, TERT, XDH 6.73497
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, PPARA, PTGS1, PTGS2 6.56773
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, PTGS2, SLC6A4, SRC 6.49067
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.1548
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 5.91728
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, RORC, SLC6A4, SRC, TYR 5.88668
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.87236
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.78703
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 5.70488
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC 5.55078
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.51728
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.51728
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TERT 5.4829
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 5.38341
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.33946
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 5.31432
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 5.14433
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 5.14433
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TNKS2, TYR 5.12001
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 5.03615
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC, TERT 4.97825
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 4.93133
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.92313
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.92245
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.84297
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 4.78653
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 4.77901
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 4.65805
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SLC6A4, SRC, TERT, TNKS2, TYR 4.61633
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.59656
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.57065
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 4.55637
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.49078
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 4.44678
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.44678
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 4.43006
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.43006
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 4.41677
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KCNH2, KDR, PTGS2, SLC6A2, SLC6A4, SRC 4.37505
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.37505
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FDPS, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC 4.34554
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 4.34554
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SLC6A4, SRC 4.31704
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FDPS 4.2913
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, F10, F3, FLT3, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.2913
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 4.2913
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.28206
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.28206
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.28206
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 4.25518
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.15394
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.1181
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.10273
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F10, F3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 4.02885
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.01614
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FDPS 3.87799
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.76671
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.62857
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 3.62857
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.5795
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.54194
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.5292
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT 3.50956
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.44485
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, MET, PIK3CA, PIK3CB, SRC, XDH 3.44225
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.36944
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, PIK3CA, PIK3CB, SRC 3.34904
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.34576
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.31644
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 3.29578
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 3.25239
[BP] GO:0040017 positive regulation of locomotion ADRA2A, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.21886
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, SRC, TNKS 3.20379
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.20379
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.17595
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CES1, CYP1A1, CYP1B1, KDR, SLC6A4, SRC 3.15056
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.14633
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 3.14081
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 3.14081
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.13876
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, PIK3CA, PIK3CB, SRC, TERT 3.10238
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FDPS, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 3.09919
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, FDPS, GBA2, TYR 3.06946
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HCAR2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.93001
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SLC6A4, SRC 2.91715
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 2.89343
[BP] GO:0051098 regulation of binding AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC, TERT, TNKS 2.8898
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.84098
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.83866
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 2.83043
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC 2.82684
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FDPS, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 2.81945
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.77834
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 2.7675
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.7533
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.7533
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.7533
[BP] GO:0009115 None AOX1, XDH 2.69641
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.69641
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KCNH2, KDR, PTGS2, SRC 2.68153
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.67153
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, RORC, SLC6A4, SRC 2.66445
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.66065
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, KCNH2, MMP9, PTGS2 2.58654
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.58042
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, SRC, TNKS, TNKS2 2.54209
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CYP19A1, HCAR2, KCNH2, MMP12, PTGS2, SLC6A4, SRC, TERT 2.52914
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.5099
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.5099
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.50034
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, PTGS2, SRC 2.50034
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, HCAR2, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SLC6A4, SRC, TERT, TNKS2, XDH 2.456
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.42545
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.42545
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, ESRRB, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.42545
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, PTGS2, SRC 2.39004
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT, TYR 2.36335
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.36268
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, BCL2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 2.36119
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2, TERT 2.36119
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.36119
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, BCL2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 2.35416
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AURKB, BCL2, CSNK2A1, CYP2D6, ESR1, ESR2, ESRRA, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.34907
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 2.34251
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.33913
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6 2.3169
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.31689
[BP] GO:0046110 None AOX1, XDH 2.31689
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.31689
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.31689
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.31278
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CDK6, CYP19A1, ESR1, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.27873
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HSD11B2, PTGS2, SLC6A4, SRC, TYR 2.26103
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.25993
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 2.25993
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.25246
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.25146
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.24883
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.23608
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, BCL2, CDK6, CYP19A1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.20651
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.19386
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.18271
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.16807
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.16807
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.16807
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.15895
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PTGS2, SLC6A4, SRC 2.14833
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.14333
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, SRC 2.1395
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, HCAR2, MET, PIK3CA, PPARA 2.10482
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, KCNH2, MET, PIK3CA, PIK3CB 2.10145
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.09737
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.09737
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.09737
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.09737
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2C19, CYP2D6 2.08859
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, ESR1, F10, F3, FLT3, FUT7, GBA2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.08859
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.08859
[BP] GO:0070213 None TNKS, TNKS2 2.08859
[BP] GO:0006145 None AOX1, XDH 2.08859
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.08859
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, FABP3, FABP4, GBA2, PIK3CB, SRC, XDH 2.0824
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.08077
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CA7, CYP19A1, HCAR2, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 2.07958
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.07165
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.06234
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.06234
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.04027
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.01233
[CC] GO:0044432 endoplasmic reticulum part BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1 4.55459
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2 3.29287
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KCNH2, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 3.29287
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, F10, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR 2.62871
[CC] GO:0031233 None CA4, F10, F3 2.19386
[CC] GO:0005783 None ADORA1, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GBA2, KDR, PTGS2, PTPN1, XDH 2.10984
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 18.8358
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.7506
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, F10, F3, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 15.7964
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 13.2595
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.5951
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TYR, XDH 9.7114
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TYR, XDH 9.42582
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.34625
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, TNKS 9.27551
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 9.22487
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 8.53357
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 8.23476
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.23476
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TYR 7.76023
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, XDH 7.63592
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 7.43007
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, TYR 7.10671
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.79763
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6 6.62826
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.88668
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 5.78703
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.91558
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.91558
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.82746
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.71187
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.49078
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SRC 4.44678
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 3.34684
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.1972
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.13951
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.12546
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.10037
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 2.97048
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.92368
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.84596
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, SRC 2.84098
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.76471
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 2.72306
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, NQO2, PTGS2, SLC6A4, TERT, TYR, XDH 2.69641
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.69641
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.69641
[MF] GO:0003845 None HSD11B1, HSD11B2 2.69641
[MF] GO:0008389 None CYP2A13, CYP2A6 2.69641
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.69641
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 2.54634
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.48327
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.43245
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.36119
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.36119
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT 2.34561
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 2.31689
[MF] GO:0005330 None SLC6A2, SLC6A4 2.31689
[MF] GO:0047374 None CES1, CES2 2.31689
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.19386
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, TERT, TYR, XDH 2.18271
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.1049
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.08859
[MF] GO:0032795 None ADORA1, ADRA2A 2.08859
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 2.04101
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 2.03266


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.945
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.9215
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.5556
Metabolic pathways_Homo sapiens_hsa01100 FDPS, AKR1B1, PTGS2, TYR, CYP2C19, GBA2, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 6.8035
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 7.4432
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.4927
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.7886
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.7886
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.285
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.7426
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 4.5256
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.5777
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.39
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5, PTGS2, CYP2C19, PTGS1, SLC6A4 4.3263
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.1472
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.1421
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.0099
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP2C19 4.1822
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.107
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.8706
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.8706
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.121
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.2621
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.3933
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, IGF1R 3.2315
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 2.8271
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9147
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8914
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, CYP2C19, PTGS1 3.2661
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.8142
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.1944
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB, ADRA2A 2.739
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.2315
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.7959
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.7462
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.671
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.9788
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1585
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.5091
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.6002
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA 2.4574
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5139
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.5184
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.2678
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.4034
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.4481
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.4481
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.4481
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.2641
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.2274
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.0751
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8955
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.7678
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.758
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.9367
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.8339
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.1297
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.8706
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.2767
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.2394
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.3959
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2619
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.6308
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8768
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4841
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4919
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2394
HTLV-I infection_Homo sapiens_hsa05166 FDPS, PIK3CA, TERT, PIK3CB 1.4844
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.5984
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.5396
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.5396
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.739
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.4946
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.4319
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.4495
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2018
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2881
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3002
Influenza A_Homo sapiens_hsa05164 FDPS, PIK3CA, PIK3CB 1.2964
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3098
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.1077
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.2377
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3623
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9355
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, ADRA2A 0.8972
Axon guidance_Homo sapiens_hsa04360 MET 0.3964
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4044
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7183
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8884
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8748
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8972
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.857
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4701
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4701
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9355
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4799
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4701
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0372
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4791
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1156
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.0615
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.0475
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4924
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1077
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0648
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4934
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0475
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4953
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4953
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.076
Gap junction_Homo sapiens_hsa04540 SRC 0.4953
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4943
Peroxisome_Homo sapiens_hsa04146 XDH 0.5072
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5485
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5467
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5578
Bile secretion_Homo sapiens_hsa04976 CA2 0.5558
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2753
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.56
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3179
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.2219
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5794
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2928
Shigellosis_Homo sapiens_hsa05131 SRC 0.5794
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5794
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3179
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4042
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.49
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4127
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.66
Malaria_Homo sapiens_hsa05144 MET 0.6722
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6815
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6767
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.5396
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5759
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6815
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8614
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.758
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1198
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8386
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.8768
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8196
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7447
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.857
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8884
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8483
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0478
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8768
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.9355
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.0139
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0901
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4003


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)