TCM Prescription: Jian Pi Syrup



Prescription Description
Prescription IDTCMF4189
Pinyin NameJian Pi Tang Jiang
Chinese Name健脾糖浆
English NameJian Pi Syrup
Function Description腹胀, 腹泻
IndicationsDiarrhea
Disease ICD-11 Category ME05.1 [Diarrhoea, 腹泻 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MPO, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 10.0507
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 9.50838
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 9.42502
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IDO1, IGF1R, INSR, MPO, POLB, PPARA, PTGS2, RORC, SRC, TEK, TYR 9.30557
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 8.98772
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.82827
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 8.7934
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, IDO1, MPO, PTGS2, RORC, SRC, TYR 8.23403
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MPO, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 8.23403
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.18811
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.17558
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 8.12026
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, HSPA1A, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR, XDH 7.87602
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, POLA1, POLB, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 7.31464
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.15117
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 7.06439
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, PTGS2, SRC, TEK 7.00326
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 7.00326
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.78965
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, NUAK1, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 6.78965
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, PTGS2, TBXAS1 6.69302
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HSD17B2, INSR, KDR, MET, MPO, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A, TYR 6.67
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MPO, NUAK1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR 6.6248
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, PTGS2, RORC, SRC, TEK, TYR 6.56886
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.56886
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, HTR6, INSR, KDR, MET, PTGS2, PTPN1, SRC, TEK, XDH 6.53261
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, PTGS2, SMAD3, SRC, TEK 6.49425
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 6.22278
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTGS2, PTPN1, SRC, TEK, XDH 6.18532
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.18532
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, PTGS2, SRC 6.17609
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 6.10552
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 6.08495
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, HTR6, INSR, KDR, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.97561
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTGS2, PTPN1, SRC, TEK, XDH 5.84105
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, POLA1, POLB, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A 5.80044
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.61537
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.563
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.45426
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TBXAS1, TYR, XDH 5.43533
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 5.42339
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.39694
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.36019
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, POLA1, POLB, SMAD3, SRC 5.25285
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.17195
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 5.09897
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.84944
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, MPO, POLB, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 4.81836
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, HTR6, IDO1, INSR, KDR, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.76594
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.7116
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, PTGS2, RORC, SMAD3, SRC 4.71057
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 4.69908
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 4.68626
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MPO, PTGS2, SRC 4.54719
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, PTGS2, RORC, SMAD3, SRC 4.50457
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.47543
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.45085
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.37375
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 4.34769
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PTGS2, TBXAS1 4.30266
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, IDO1, MPO, NUAK1, POLA1, POLB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 4.25944
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, POLB, PPARA, PTGS2, SMAD3, SRC, TEK 4.14755
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IDO1, IGF1R, MET, MMP12, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.14755
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HSD17B2, IDO1, IGF1R, INSR, MET, MMP12, MPO, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.12237
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, POLB, PTGS2, SRC 4.07845
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.06692
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 4.05253
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, POLB, SRC 3.99749
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 3.98959
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.88413
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.87036
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, FLT3, MET, PIM1, POLA1, SRC, TEK, TYR 3.82111
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.81365
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, IDO1, MMP12, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.81365
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.81365
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 3.81284
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MPO 3.79976
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.78188
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.76256
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.76045
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.76045
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 3.73833
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 3.73557
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 3.71936
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.69787
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.69787
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, SRC 3.69787
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, SRC 3.67681
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.64168
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, EGFR, FLT3, PTGS2, RORC, SRC 3.62489
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, PPARA, PTGS2, SMAD3, SRC, TEK 3.61668
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 3.61668
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.61668
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, FLT3, FUT7, GLO1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.55426
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, PPARA, PTGS2, SMAD3, SRC, TEK 3.53175
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.53175
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 3.52386
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.52386
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, EGFR, HCAR2, KDR, PTGS2, SRC 3.50012
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.49631
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, PPARA, PTGS2, TBXAS1 3.47592
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TOP2A 3.47592
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.44622
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MPO 3.44622
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 3.43778
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, SRC 3.43161
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 3.42867
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, IDO1 3.42867
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 3.42867
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, PTGS2, SRC 3.41108
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PTGS2, TEK 3.39819
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, PPARA, RORC, SRC, TOP2A 3.39451
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK 3.35741
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK 3.35454
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.33954
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK, TYR 3.32221
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.30217
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HSD17B1, HSD17B2 3.2988
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2, TBXAS1 3.28837
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.28837
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 3.27241
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 3.24489
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, FABP4, IDO1, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 3.20998
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, IDO1, MPO 3.1752
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, PTGS2, SRC 3.147
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.12956
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.12822
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.12822
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 3.12249
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 3.12249
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGS2, SMAD3, SRC 3.09319
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK 3.07488
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, XDH 3.06893
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, EGFR, HCAR2, INSR, MMP12, PTGS2, SMAD3, SRC 3.06488
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, XDH 3.06299
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 3.06299
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 3.05418
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, MPO, PTGS2, SRC, TYR 3.05418
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, IDO1, MMP12, MPO, SRC, XDH 3.05418
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK, TYR 3.05418
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, MPO, POLB, PTGS2 3.04538
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 3.02514
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 3.01705
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 3.01705
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.01097
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.99453
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP12, PPARA, PTGS2, PTPN1, SMAD3, SRC 2.99453
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, PTGS2, SRC 2.99352
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 2.99352
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.98204
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, NUAK1, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.97643
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGS2, SMAD3, SRC 2.96746
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.95669
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.95669
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 2.95014
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.95014
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.95014
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, PIM1, PPARA, PTGS2, PTPN1, SRC 2.92659
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.9016
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.89673
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, PTGS2, PTPN1, SRC 2.8965
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.8965
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, NUAK1, POLA1, POLB, PTGS2, PTPN1, SRC, TOP2A 2.89224
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, EGFR, HCAR2, HSPA1A, IDO1, KDR, MET, MMP12, PIM1, PTGS2, SMAD3, SRC, TEK 2.86774
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TEK, TYR 2.85174
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, HSD17B2, INSR, PTGS2, SRC 2.81026
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 2.80574
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.80185
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, PTGS2, PTPN1, SRC, TEK, XDH 2.79731
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.79731
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.79731
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.79731
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.79731
[BP] GO:0051704 multi-organism process AXL, BCL2, CHRM2, CYP1A1, EGFR, HSPA1A, IDO1, INSR, KDR, MET, MMP12, MPO, POLA1, SMAD3, SRC 2.78094
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MET, PPARA, SMAD3 2.76533
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.76209
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, EGFR, IDO1, MMP12, MPO, PTGS2, SMAD3, SRC, TYR 2.73578
[BP] GO:0031399 regulation of protein modification process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 2.73578
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC 2.73407
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.704
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.69552
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.69552
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.64171
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.64171
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PTGS2, SRC, TEK 2.64141
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 2.634
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CHRM2, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, IDO1, INSR, KDR, MET, MMP12, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 2.62515
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.60804
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.60686
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.60371
[BP] GO:0016311 None ALPL, APEX1, BCL2, CDC25B, DUSP3, POLB, PTPN1 2.59402
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.58216
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58216
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.58216
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.58005
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, HSPA1A, IGF1R, MET, PTGS2, PTPN1, SRC, XDH 2.58005
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, PTGS2, PTPN1, SRC, TEK, XDH 2.57862
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.57786
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.57786
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.55859
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, MPO, PTGS2, SRC, TYR 2.51492
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.50604
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.49695
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.49695
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.49572
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, EGFR, PTGS2 2.49572
[BP] GO:0030155 regulation of cell adhesion BCL2, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.49428
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.48725
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.48366
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.48366
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.44628
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.43998
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, PTGS2, SRC, TEK 2.43998
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.43814
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.43363
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.43363
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, PTGS2, PTPN1, SRC, TEK, XDH 2.43363
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.40482
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.36013
[BP] GO:0051894 None KDR, SMAD3, TEK 2.35264
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, HSD17B2, IDO1, INSR, PTGS2, SRC, TOP2A 2.35124
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, BCL2, CYP1B1, FABP3, HSPA1A, IDO1, PTGS2, SMAD3, XDH 2.34644
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3446
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, PTGS2 2.34228
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.34092
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, TYR 2.34065
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, PTGS2, SRC 2.32142
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.29926
[BP] GO:1903393 None KDR, SMAD3, TEK 2.26468
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, PTGS2 2.263
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, PTGS2 2.26197
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.24825
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.20275
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DUSP3, INSR 2.19685
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.16393
[BP] GO:0098501 polynucleotide dephosphorylation APEX1, POLB 2.15284
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, PTGS2 2.1466
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.14155
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.14081
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.14073
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, EGFR, IGF1R, INSR, PTGS2, RORC, SRC 2.13557
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, HCAR2, IDO1, PTGS2, SMAD3, SRC, TOP2A, XDH 2.13557
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.13083
[BP] GO:0051186 None AKR1B1, AKR1B10, CYP1A1, CYP1A2, EGFR, GLO1, MPO, PTGS2 2.12698
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, HCAR2, IDO1, PTGS2, SMAD3, SRC, TOP2A, XDH 2.10759
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.10759
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK 2.09989
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.09989
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TOP2A 2.08201
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TOP2A 2.08201
[BP] GO:0003018 None ADORA1, EGFR, PTGS2, SRC, TEK 2.07518
[BP] GO:1901890 None KDR, SMAD3, TEK 2.07423
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1 2.07101
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3 2.07101
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.07101
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.07101
[BP] GO:0043412 macromolecule modification ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TOP2A 2.06812
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, PTGS2, PTPN1, SRC 2.0472
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.04347
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.03689
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, PTGS2, SMAD3 2.03266
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, MMP12, SRC 2.03266
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PTGS2, TEK 2.02679
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.02679
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.02337
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.01776
[BP] GO:0010907 None INSR, PPARA, SRC 2.01776
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.01638
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC 2.01587
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.64141
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CYP19A1, FLT3, HSPA1A, KDR, PTGS2, PTPN1, XDH 2.03511
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.02679
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, EGFR, FLT3, GLO1, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PIM1, PTPN1, SMAD3, SRC, TEK 2.01638
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM2, EGFR, INSR, MET, PTGS2, SRC, TEK 1.924
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PTGS2, PTPN1, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 11.0172
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0507
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 9.30557
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 8.51565
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP12, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 8.23403
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.74115
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.99066
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC, TBXAS1 6.78965
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB 6.74372
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.6248
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC, TBXAS1 6.58652
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TBXAS1, TYR, XDH 6.56197
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A 5.76835
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.71049
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, IDO1, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TOP2A, TYR, XDH 5.12077
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, IDO1, MPO, POLA1, PTGS2, SRC, TBXAS1, XDH 5.06427
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, IDO1, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TOP2A, TYR, XDH 4.76594
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.60231
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC 4.18212
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 4.07502
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.92826
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1, TYR 3.9172
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 3.83811
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.81959
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.81284
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 3.79448
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.6455
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.50641
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.42867
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 3.33954
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP12, PPARA, PTPN1, RORC, SMAD3 3.07955
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.06299
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A, XDH 3.05418
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.8965
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK 2.89224
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.89224
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.81218
[MF] GO:1901363 heterocyclic compound binding ADORA1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, XDH 2.74091
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.68027
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.68027
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, TEK 2.65301
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, TEK 2.65301
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.53026
[MF] GO:0097159 organic cyclic compound binding ADORA1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, XDH 2.5101
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.43814
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A, XDH 2.43497
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A, XDH 2.43387
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.41661
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.3751
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.29926
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MPO, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A 2.28238
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.26468
[MF] GO:0019899 enzyme binding AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, HSPA1A, MET, POLA1, POLB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 2.24707
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.22212
[MF] GO:0043559 insulin binding IGF1R, INSR 2.15284
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.14081
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, DUSP3, POLA1, PTPN1 2.13557
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.07423
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MPO, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.0449
[MF] GO:0004064 arylesterase activity CA1, CA2 2.02679


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 11.6784
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.6784
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.5981
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.1348
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP19A1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 4.8586
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.1163
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.8508
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 3.8935
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.7095
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.6824
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, PTGS2, MET, EGFR, CDC25B 3.4566
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.4566
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2 3.5013
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.2061
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, BCL2, PTGS2, MET, EGFR, IGF1R 2.8142
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, EGFR, IGF1R 2.5659
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, ADORA1, PPARA 2.5822
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 3.0114
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3051
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.249
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2277
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6, GPR35, ADORA3, ADORA1 2.1421
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2 2.2486
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.1884
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1874
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1665
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, MPO, IGF1R 1.9974
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.9586
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2, PIM1 1.8422
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.1475
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.186
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, EGFR, HSPA1A 1.8539
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.7852
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.9179
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.786
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.6442
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, ALOX5, PTGS2 1.7849
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.7426
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5959
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7324
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2 1.5364
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.4527
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.4142
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, EGFR 1.3752
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.2556
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 1.2014
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9622
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1207
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3752
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.1665
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1888
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9031
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1472
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4336
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9618
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9144
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 1.1912
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8983
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9618
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8935
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8935
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8887
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8983
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.3893
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8639
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2556
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3752
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1866
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8462
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4142
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3752
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.817
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.803
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3752
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.803
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.7206
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.6139
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3656
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3652
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3809
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4209
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4284
Phagosome_Homo sapiens_hsa04145 MPO 0.4209
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4447
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.6637
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4569
Axon guidance_Homo sapiens_hsa04360 MET 0.4729
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4812
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4869
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4897
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2 0.5122
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5337
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5337
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5337
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5262
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5337
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.833
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5361
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.5259
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5357
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5337
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5488
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5496
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5508
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5508
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5613
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5502
Peroxisome_Homo sapiens_hsa04146 XDH 0.5622
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.6005
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6005
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6005
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5989
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6014
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5874
Bile secretion_Homo sapiens_hsa04976 CA2 0.6005
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6139
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6029
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6164
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7894
Shigellosis_Homo sapiens_hsa05131 SRC 0.6144
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6377
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.786
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9974
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.744
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6609
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6639
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6821
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6857
Malaria_Homo sapiens_hsa05144 MET 0.6975
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7014
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.714
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7678
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.803
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.803
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.762
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8604
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8236
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.803
DNA replication_Homo sapiens_hsa03030 POLA1 0.7959
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8413
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8639
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8324
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8604
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0703
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0562


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)