Prescription ID | TCMF4068 |
Pinyin Name | Gui Lu Ning Shen Wan |
Chinese Name | 龟鹿宁神丸 |
English Name | Gui Lu Ning Shen Pills |
Function Description | 惊悸, 不寐, 眩晕, 耳鸣 |
Indications | Inducible palpitation disorder, Tinnitus disorder, Vertigo disorder, Insomnia disorder, Insomnia, Tinnitus, Dizziness |
Disease ICD-11 Category |
SA10 [Inducible palpitation disorder (TM1), 惊悸 (TM1)
]; SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ]; SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ]; SD84 [Insomnia disorder (TM1), 不寐 (TM1) ]; 7A0Z [Insomnia disorders, unspecified, 失眠障碍,未特指的 ]; MC41 [Tinnitus, 耳鸣 ]; MB48 [Dizziness and giddiness, 头晕和眩晕 ]; |
Human Tissues Associated with Indication | Heart, Brain |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH747 | Carapax et plastrum testudinis | 龟甲胶 | TCMH747 | |
TCMH1345 | Pulvis cornu cervi | 鹿角胶 | TCMH1345 | |
TCMH2052 | Ziziphus jujuba var. spinosa | 酸枣仁 | TCMH2052 | ITSAM943-14 |
TCMH2554 | Polygala tenuifolia | 远志 | TCMH2554 | MF096619 |
TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
TCMH1966 | Rehmannia glutinosa | 熟地黄 | TCMH1966 | ITSAH4578-14 |
TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
TCMH305 | Cnidium officinale | 川芎 | TCMH305 | ITSAP4207-14 |
TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
TCMH407 | Salvia miltiorrhiza | 丹参 | TCMH407 | ITSAH2408-14 |
TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
TCMH1803 | Amomum villosum | 砂仁 | TCMH1803 | ITSAD521-14 |
TCMH1845 | Dioscorea batatas | 山药 | TCMH1845 | |
TCMH1663 | Semen euryales | 芡实 | TCMH1663 | |
TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT139 | CA6 | Carbonic anhydrase VI | Lyase | P23280 |
TCMT140 | CA5B | Carbonic anhydrase VB | Lyase | Q9Y2D0 |
TCMT141 | CA5A | Carbonic anhydrase VA | Lyase | P35218 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
TCMT171 | PTPN6 | Protein-tyrosine phosphatase 1C | Hydrolase | P29350 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT189 | DUSP3 | Dual specificity protein phosphatase 3 | Hydrolase | P51452 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
TCMT209 | HSD11B2 | 11-beta-hydroxysteroid dehydrogenase 2 | Oxidoreductase | P80365 |
TCMT210 | CES2 | Carboxylesterase 2 | Hydrolase | O00748 |
TCMT211 | CES1 | Acyl coenzyme A:cholesterol acyltransferase | Transferase | P23141 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
TCMT231 | GBA2 | Beta-glucosidase | Hydrolase | Q9HCG7 |
TCMT233 | PTPN11 | Protein-tyrosine phosphatase 2C | Hydrolase | Q06124 |
TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT247 | ADRA2A | Alpha-2a adrenergic receptor | GPCR | P08913 |
TCMT249 | CDK6 | Cyclin-dependent kinase 6 | Kinase | Q00534 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT302 | HMGCR | HMG-CoA reductase | Oxidoreductase | P04035 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT307 | KCNH2 | HERG | Ion channel | Q12809 |
TCMT31 | CYP2C19 | Cytochrome P450 2C19 | Oxidoreductase | P33261 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT332 | AOC3 | Amine oxidase, copper containing | Oxidoreductase | Q16853 |
TCMT344 | AOX1 | Aldehyde oxidase | Oxidoreductase | Q06278 |
TCMT354 | AURKA | Serine/threonine-protein kinase Aurora-A | Kinase | O14965 |
TCMT359 | FYN | Tyrosine-protein kinase FYN | Kinase | P06241 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT377 | INSR | Insulin receptor | Kinase | P06213 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT418 | EPHB4 | Ephrin type-B receptor 4 | Kinase | P54760 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT423 | EGFR | Epidermal growth factor receptor erbB1 | Kinase | P00533 |
TCMT436 | NUAK1 | NUAK family SNF1-like kinase 1 | Kinase | O60285 |
TCMT44 | GLO1 | Glyoxalase I | Lyase | Q04760 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT457 | FLT4 | Vascular endothelial growth factor receptor 3 | Kinase | P35916 |
TCMT46 | F3 | Coagulation factor III | Unclassified | P13726 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT47 | BCL2 | Apoptosis regulator Bcl-2 | Ion channel | P10415 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT502 | TEK | Tyrosine-protein kinase TIE-2 | Kinase | Q02763 |
TCMT506 | PTK2B | Protein tyrosine kinase 2 beta | Kinase | Q14289 |
TCMT536 | PDGFRB | Platelet-derived growth factor receptor beta | Kinase | P09619 |
TCMT558 | TOP2A | DNA topoisomerase II alpha | Isomerase | P11388 |
TCMT560 | F10 | Coagulation factor X | Unclassified | P00742 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT591 | ESRRA | Estrogen-related receptor alpha | Nuclear receptor | P11474 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT599 | UBE2N | Ubiquitin-conjugating enzyme E2 N | Transferase | P61088 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT626 | BRAF | Serine/threonine-protein kinase B-raf | Kinase | P15056 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT633 | SLC6A4 | Serotonin transporter | Transporter | P31645 |
TCMT634 | SLC6A2 | Norepinephrine transporter | Transporter | P23975 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT690 | HDAC3 | Histone deacetylase 3 | Hydrolase | O15379 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT721 | HSPA1A | Heat shock 70 kDa protein 1 | Unclassified | P0DMV8 |
TCMT734 | MMP12 | Matrix metalloproteinase 12 | Hydrolase | P39900 |
TCMT737 | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | Unclassified | Q9HC16 |
TCMT739 | GPR35 | G-protein coupled receptor 35 | GPCR | Q9HC97 |
TCMT740 | PIK3CG | PI3-kinase p110-gamma subunit | Transferase | P48736 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT753 | SMAD3 | Mothers against decapentaplegic homolog 3 | Unclassified | P84022 |
TCMT755 | PLK4 | Serine/threonine-protein kinase PLK4 | Kinase | O00444 |
TCMT756 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Kinase | P41279 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT83 | CD38 | Lymphocyte differentiation antigen CD38 | Unclassified | P28907 |
TCMT907 | FDPS | Farnesyl diphosphate synthase | Lyase | P14324 |
TCMT910 | ESRRB | Estrogen-related receptor beta | Nuclear receptor | O95718 |
Target ID | Target Name |
---|---|
TCMT1168 | Trichomonas vaginalis |
TCMT1170 | Enterobacter cloacae |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1179 | Escherichia coli ATCC 8739 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1186 | Plasmodium yoelii yoelii |
TCMT1189 | Pseudomonas fluorescens |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1210 | Streptococcus sobrinus |
TCMT1211 | Fusobacterium nucleatum |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1218 | Staphylococcus aureus |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1224 | Proteus mirabilis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1227 | Streptococcus |
TCMT1229 | Enterococcus faecalis |
TCMT1231 | Human herpesvirus 1 strain KOS |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1234 | Bacillus coagulans |
TCMT1235 | Clostridium sporogenes |
TCMT1236 | Mycobacterium bovis |
TCMT1237 | Mycobacterium kansasii |
TCMT1238 | Mycobacterium xenopi |
TCMT1239 | Mycobacterium marinum |
TCMT1243 | Aspergillus flavus |
TCMT1245 | Phytophthora cactorum |
TCMT1246 | Escherichia coli |
TCMT1248 | Hepatitis C virus |
TCMT1249 | Dengue virus 2 |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1282 | Colletotrichum orbiculare |
TCMT1284 | Penicillium expansum |
TCMT1286 | Bacillus cereus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1321 | Staphylococcus hominis |
TCMT1343 | Staphylococcus simulans |
TCMT1344 | Staphylococcus sciuri |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1370 | Prevotella melaninogenica |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1393 | Vibrio sp. |
TCMT1405 | Penicillium citrinum |
TCMT1408 | Colletotrichum gloeosporioides |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1444 | Fusarium oxysporum |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1457 | Leishmania major |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH | 12.3318 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, ESR1, FDPS, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 11.8819 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 11.0757 |
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA | 10.7374 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.2872 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, FDPS, FUT7, GBA2, GLO1, HMGCR, HSPA1A, PIM1, PPARA, TYR, XDH | 10.2872 |
[BP] GO:0042221 | response to chemical | ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR | 10.2872 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MET, PPARA, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH | 9.6469 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH | 9.6469 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, RORC, SLC6A4, SRC, TEK, TYR | 9.49351 |
[BP] GO:0010033 | response to organic substance | ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TYR | 9.39828 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH | 9.39828 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH | 9.33613 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH | 9.30841 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR | 9.0802 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH | 8.78903 |
[BP] GO:0009725 | response to hormone | ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, PPARA, SLC6A4, SRC, TEK | 8.49114 |
[BP] GO:0009719 | response to endogenous stimulus | ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK | 7.95018 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 7.95018 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 7.95018 |
[BP] GO:0033993 | response to lipid | ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, RORC, SLC6A4, SRC, TYR | 7.84873 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH | 7.33087 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 7.33087 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH | 7.28526 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH | 7.18045 |
[BP] GO:0014070 | response to organic cyclic compound | ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, RORC, SLC6A4, SRC, TEK, TYR | 6.95777 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT | 6.92233 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 | 6.83287 |
[BP] GO:0070887 | cellular response to chemical stimulus | ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, RORC, SLC6A4, SMAD3, SRC, TERT | 6.7922 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT | 6.69079 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, MET, PPARA | 6.59432 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT | 6.58806 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT | 6.5861 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH | 6.5861 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR | 6.56168 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR | 6.52233 |
[BP] GO:0008284 | positive regulation of cell proliferation | ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK, TERT | 6.4831 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT | 6.48279 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH | 6.47308 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT | 6.45813 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT | 6.44117 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TNKS2, TYR | 6.35392 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH | 6.28116 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH | 6.01806 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT | 5.99027 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CES1, CYP19A1, FDPS, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 5.90236 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR | 5.89871 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 5.86826 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH | 5.86231 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH | 5.80931 |
[BP] GO:0030335 | positive regulation of cell migration | ADRA2A, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT | 5.73999 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH | 5.70675 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 5.66457 |
[BP] GO:2000147 | positive regulation of cell motility | ADRA2A, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT | 5.57836 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 | 5.57836 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC, TERT | 5.54018 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK | 5.46511 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HMGCR, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH | 5.46511 |
[BP] GO:0051272 | positive regulation of cellular component movement | ADRA2A, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT | 5.45638 |
[BP] GO:0042493 | response to drug | AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, HSD11B2, KCNH2, KDR, SLC6A2, SLC6A4, SRC | 5.45638 |
[BP] GO:0051716 | cellular response to stimulus | ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NUAK1, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A | 5.42252 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, EGFR, HCAR2, HMGCR, KDR, SRC, TNKS, TNKS2 | 5.42252 |
[BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT | 5.41812 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 | 5.38906 |
[BP] GO:0036293 | response to decreased oxygen levels | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT | 5.2967 |
[BP] GO:0040017 | positive regulation of locomotion | ADRA2A, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT | 5.2967 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, XDH | 5.2234 |
[BP] GO:0071310 | cellular response to organic substance | ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RORC, SLC6A4, SMAD3, SRC | 5.10933 |
[BP] GO:0006805 | xenobiotic metabolic process | CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, RORC | 5.10539 |
[BP] GO:0080134 | regulation of response to stress | ADORA1, ADRA2A, CDK6, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 5.09976 |
[BP] GO:0070482 | response to oxygen levels | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT | 4.96445 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, ADRA2A, CYP1A1, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC, TEK | 4.96035 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH | 4.90292 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA | 4.90292 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, XDH | 4.86862 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FDPS, HMGCR | 4.85256 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2C19 | 4.85175 |
[BP] GO:0006468 | protein phosphorylation | AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS | 4.80548 |
[BP] GO:0010648 | negative regulation of cell communication | ACHE, ADORA1, ADRA2A, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH | 4.79035 |
[BP] GO:0023057 | negative regulation of signaling | ACHE, ADORA1, ADRA2A, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH | 4.77581 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.67675 |
[BP] GO:0019369 | arachidonic acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 | 4.64366 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.62924 |
[BP] GO:0007346 | regulation of mitotic cell cycle | APEX1, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS, TOP2A | 4.62613 |
[BP] GO:0032787 | None | ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GBA2, GLO1, PPARA | 4.62123 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH | 4.58326 |
[BP] GO:0009636 | response to toxic substance | AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CYP1A1, CYP1B1, HMGCR, KDR, SLC6A4, SRC | 4.57392 |
[BP] GO:0009966 | regulation of signal transduction | ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH | 4.50367 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH | 4.47936 |
[BP] GO:0048583 | regulation of response to stimulus | ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH | 4.47267 |
[BP] GO:0048585 | negative regulation of response to stimulus | ADORA1, ADRA2A, BCL2, CDK6, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 4.44542 |
[BP] GO:0042592 | homeostatic process | ADORA1, ADRA2A, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, KCNH2, MET, SMAD3, SRC, TERT | 4.44328 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HMGCR, HSD11B2, HSPA1A, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT, TYR | 4.44328 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA | 4.42033 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH | 4.40446 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 4.38746 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, EGFR, F10, F3, INSR, MET, SRC, TEK | 4.3063 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH | 4.29491 |
[BP] GO:0032847 | regulation of cellular pH reduction | BCL2, CA2, CA7 | 4.29491 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 | 4.25782 |
[BP] GO:0051239 | regulation of multicellular organismal process | ADORA1, ADORA3, ADRA2A, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HMGCR, HSPA1A, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIM1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH | 4.22183 |
[BP] GO:0048511 | rhythmic process | AXL, BCL2, CSNK2A1, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC, TOP2A | 4.21484 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FDPS | 4.21254 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 4.19123 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC | 4.19123 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, ADRA2A, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH | 4.1719 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, FABP4, FUT7, GBA2, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH | 4.14536 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH | 3.96995 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.9125 |
[BP] GO:0030522 | intracellular receptor signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC | 3.89718 |
[BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, EGFR, HMGCR, MMP2, MMP9, TERT | 3.87758 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK | 3.68609 |
[BP] GO:0043401 | steroid hormone mediated signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC | 3.68164 |
[BP] GO:0016310 | phosphorylation | AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS | 3.65586 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, FDPS, GBA2, HMGCR, TYR | 3.65586 |
[BP] GO:0038083 | peptidyl-tyrosine autophosphorylation | EGFR, IGF1R, INSR, KDR, SRC | 3.61245 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR | 3.608 |
[BP] GO:0051726 | regulation of cell cycle | APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SLC6A4, SMAD3, SRC, TERT, TNKS, TOP2A | 3.59862 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS | 3.59862 |
[BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 3.59742 |
[BP] GO:0043405 | regulation of MAP kinase activity | ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC | 3.5791 |
[BP] GO:0050790 | regulation of catalytic activity | ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH | 3.53561 |
[BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH | 3.52433 |
[BP] GO:0051049 | regulation of transport | ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HCAR2, HMGCR, HSPA1A, INSR, KCNH2, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TERT | 3.52433 |
[BP] GO:0071407 | cellular response to organic cyclic compound | ALPL, APEX1, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, RORC, SLC6A4, SRC | 3.4688 |
[BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.46499 |
[BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.46499 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH | 3.44349 |
[BP] GO:0032845 | None | ADORA1, ADRA2A, BCL2, HMGCR, SRC, TNKS, TNKS2 | 3.43608 |
[BP] GO:0051050 | positive regulation of transport | ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CYP19A1, EGFR, HCAR2, INSR, KCNH2, MMP12, SLC6A4, SMAD3, SRC, TERT | 3.42178 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.39871 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH | 3.39651 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KCNH2, KDR, SRC | 3.37475 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GBA2, GLO1, PIM1, PPARA, TYR | 3.37033 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA | 3.36231 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, RORC, SLC6A4, SRC | 3.34517 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, HMGCR, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 3.34517 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, HMGCR, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 3.34517 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.30966 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APEX1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, SLC6A4, SRC, TEK, TYR | 3.30641 |
[BP] GO:0045787 | positive regulation of cell cycle | APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT | 3.29985 |
[BP] GO:0018193 | peptidyl-amino acid modification | AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP2A | 3.27672 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 | 3.27583 |
[BP] GO:0003018 | None | ADORA1, ADRA2A, EGFR, HMGCR, SLC6A4, SRC, TEK | 3.26551 |
[BP] GO:0051701 | interaction with host | AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC | 3.21519 |
[BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, KDR, SMAD3, SRC, TEK | 3.21052 |
[BP] GO:0034502 | protein localization to chromosome | AURKB, ESR1, TERT, TNKS, TNKS2 | 3.20978 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK | 3.18804 |
[BP] GO:0051240 | positive regulation of multicellular organismal process | ADRA2A, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, F3, HCAR2, HMGCR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TERT | 3.1854 |
[BP] GO:0065009 | regulation of molecular function | ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH | 3.16034 |
[BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC | 3.11366 |
[BP] GO:0009894 | regulation of catabolic process | ADORA1, ADRA2A, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 | 3.09923 |
[BP] GO:0009755 | hormone-mediated signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC | 3.08807 |
[BP] GO:0009892 | negative regulation of metabolic process | ADORA1, ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH | 3.08519 |
[BP] GO:0019222 | regulation of metabolic process | ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH | 3.05787 |
[BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 2.99122 |
[BP] GO:0009968 | negative regulation of signal transduction | ADRA2A, BCL2, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TERT, XDH | 2.98655 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APEX1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, SLC6A4, SRC, TEK, TYR | 2.98058 |
[BP] GO:0048878 | chemical homeostasis | ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, KCNH2, MET, SMAD3 | 2.94715 |
[BP] GO:0044093 | positive regulation of molecular function | ADORA1, ADRA2A, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH | 2.94398 |
[BP] GO:0043408 | regulation of MAPK cascade | ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH | 2.93282 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GBA2, GLO1, PIM1, PPARA, TYR | 2.93161 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, ADRA2A, EGFR, FLT3, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH | 2.9284 |
[BP] GO:0042180 | None | AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR | 2.92284 |
[BP] GO:0010907 | None | ESRRB, INSR, PPARA, SRC | 2.92284 |
[BP] GO:0009611 | response to wounding | ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 | 2.91826 |
[BP] GO:0010638 | positive regulation of organelle organization | AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 | 2.91277 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | BCL2, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH | 2.89118 |
[BP] GO:0048869 | cellular developmental process | ACHE, ALPL, AXL, BCL2, CDC25B, CDK6, CES1, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, KDR, MET, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TERT, TOP2A | 2.87196 |
[BP] GO:0006082 | organic acid metabolic process | ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GBA2, GLO1, PIM1, PPARA, TYR | 2.85662 |
[BP] GO:0022414 | reproductive process | AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, MMP2, MMP9, SLC6A4, SRC, TOP2A | 2.83395 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, EGFR, HSPA1A | 2.816 |
[BP] GO:0009991 | response to extracellular stimulus | ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, SLC6A4, SRC, TYR | 2.80839 |
[BP] GO:0042738 | exogenous drug catabolic process | CYP1A2, CYP2A6, CYP2C19 | 2.80416 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 2.80416 |
[BP] GO:0051098 | regulation of binding | AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS | 2.80416 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, ADRA2A, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH | 2.80416 |
[BP] GO:0009895 | negative regulation of catabolic process | ADORA1, ADRA2A, BCL2, EGFR, HCAR2, MET, PPARA, SMAD3 | 2.78272 |
[BP] GO:0009115 | None | AOX1, XDH | 2.76832 |
[BP] GO:0048660 | regulation of smooth muscle cell proliferation | AKR1B1, EGFR, HMGCR, MMP2, MMP9, TERT | 2.76139 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, ADRA2A, BCL2, CDC25B, EGFR, ESRRB, FLT3, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 2.76139 |
[BP] GO:1901652 | response to peptide | AKR1B1, APEX1, FABP3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK | 2.76139 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 | 2.71566 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.71206 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR | 2.69045 |
[BP] GO:0051338 | regulation of transferase activity | ADORA1, ADRA2A, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK, TNKS | 2.63816 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.61412 |
[BP] GO:0043085 | positive regulation of catalytic activity | ADORA1, ADRA2A, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH | 2.60124 |
[BP] GO:0032101 | regulation of response to external stimulus | ADORA1, CYP19A1, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, MMP12, PPARA, SMAD3, TEK | 2.59468 |
[BP] GO:0002009 | morphogenesis of an epithelium | BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 2.59468 |
[BP] GO:0003013 | None | ADORA1, ADRA2A, EGFR, HMGCR, SLC6A4, SRC, TEK | 2.59468 |
[BP] GO:0043393 | regulation of protein binding | AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT | 2.59468 |
[BP] GO:0031347 | regulation of defense response | ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK | 2.57713 |
[BP] GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A | 2.55971 |
[BP] GO:0043271 | negative regulation of ion transport | ADORA1, ADRA2A, BCL2, GPR35, KCNH2, MMP9 | 2.54998 |
[BP] GO:0070198 | None | TERT, TNKS, TNKS2 | 2.53794 |
[BP] GO:0071495 | cellular response to endogenous stimulus | ADRA2A, AKR1B1, APEX1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, SLC6A4, SMAD3, SRC | 2.53172 |
[BP] GO:0051130 | positive regulation of cellular component organization | AURKB, AXL, BCL2, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 | 2.53172 |
[BP] GO:1903727 | positive regulation of phospholipid metabolic process | FABP3, FLT3, SRC, TEK | 2.53172 |
[BP] GO:0045931 | positive regulation of mitotic cell cycle | APEX1, CDC25B, CYP1A1, DUSP3, INSR, TERT | 2.51072 |
[BP] GO:0051054 | positive regulation of DNA metabolic process | AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 | 2.50924 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.46449 |
[BP] GO:0070920 | None | EGFR, ESR1, TERT | 2.46449 |
[BP] GO:0001954 | positive regulation of cell-matrix adhesion | CDK6, KDR, SMAD3, TEK | 2.46449 |
[BP] GO:0048545 | response to steroid hormone | ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, SRC | 2.44254 |
[BP] GO:0080090 | regulation of primary metabolic process | ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH | 2.43054 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 2.4291 |
[BP] GO:0060255 | regulation of macromolecule metabolic process | ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH | 2.41998 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ADRA2A, BCL2, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 2.40746 |
[BP] GO:1904355 | positive regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.39931 |
[BP] GO:0003006 | developmental process involved in reproduction | ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC | 2.39592 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, EGFR, HCAR2, TNKS, TNKS2 | 2.37217 |
[BP] GO:0046110 | None | AOX1, XDH | 2.3691 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.3691 |
[BP] GO:0031960 | response to corticosteroid | ALPL, BCL2, EGFR, FLT3, HSD11B2, SRC | 2.36757 |
[BP] GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | BCL2, HSPA1A, MMP9, PTPN1, SRC | 2.36495 |
[BP] GO:0010564 | regulation of cell cycle process | APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, TERT, TNKS | 2.36222 |
[BP] GO:0071900 | regulation of protein serine/threonine kinase activity | ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC | 2.34948 |
[BP] GO:0010906 | None | ESRRB, INSR, PPARA, RORC, SRC | 2.34934 |
[BP] GO:0016137 | None | AKR1B1, AKR1B10, GBA2 | 2.34175 |
[BP] GO:0031667 | response to nutrient levels | ALPL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, SLC6A4, SRC, TYR | 2.34116 |
[BP] GO:0009891 | positive regulation of biosynthetic process | AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A | 2.3198 |
[BP] GO:0010557 | positive regulation of macromolecule biosynthetic process | AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A | 2.31261 |
[BP] GO:0043549 | regulation of kinase activity | ADORA1, ADRA2A, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK | 2.30792 |
[BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.30769 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ADRA2A, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 2.29341 |
[BP] GO:0010038 | response to metal ion | BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, TERT | 2.29341 |
[BP] GO:1901617 | organic hydroxy compound biosynthetic process | AKR1B1, CES1, CYP19A1, FDPS, HMGCR, TYR | 2.28224 |
[BP] GO:0051900 | regulation of mitochondrial depolarization | BCL2, KDR, SRC | 2.28197 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SLC6A4, SRC | 2.27361 |
[BP] GO:0010676 | None | ESRRB, INSR, PPARA, SRC | 2.27361 |
[BP] GO:0050994 | None | ADORA1, ADRA2A, HCAR2, PPARA | 2.27361 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ADORA1, ADRA2A, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH | 2.27361 |
[BP] GO:0051828 | entry into other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.27361 |
[BP] GO:0051806 | entry into cell of other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.27361 |
[BP] GO:0030260 | entry into host cell | AXL, EGFR, HSPA1A, MET, SRC | 2.27361 |
[BP] GO:0044409 | entry into host | AXL, EGFR, HSPA1A, MET, SRC | 2.27361 |
[BP] GO:0072593 | reactive oxygen species metabolic process | BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR | 2.25467 |
[BP] GO:0050793 | regulation of developmental process | AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, HMGCR, INSR, KDR, NUAK1, PIM1, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH | 2.25403 |
[BP] GO:0032210 | regulation of telomere maintenance via telomerase | AURKB, SRC, TNKS, TNKS2 | 2.25247 |
[BP] GO:0019538 | protein metabolic process | ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A | 2.24487 |
[BP] GO:0048732 | gland development | BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR | 2.23902 |
[BP] GO:0051893 | regulation of focal adhesion assembly | KDR, SMAD3, SRC, TEK | 2.22927 |
[BP] GO:0090109 | regulation of cell-substrate junction assembly | KDR, SMAD3, SRC, TEK | 2.22927 |
[BP] GO:0006950 | response to stress | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A | 2.22927 |
[BP] GO:0050678 | None | CDK6, EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH | 2.22515 |
[BP] GO:2000377 | regulation of reactive oxygen species metabolic process | BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH | 2.21485 |
[BP] GO:0031324 | negative regulation of cellular metabolic process | ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH | 2.20377 |
[BP] GO:0031348 | negative regulation of defense response | ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK | 2.18943 |
[BP] GO:0046686 | response to cadmium ion | CYP1A2, EGFR, MMP9, TERT | 2.1751 |
[BP] GO:0051172 | None | ADRA2A, APEX1, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH | 2.16746 |
[BP] GO:0080135 | regulation of cellular response to stress | CDK6, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PTPN1, TERT, XDH | 2.1614 |
[BP] GO:1903391 | regulation of adherens junction organization | KDR, SMAD3, SRC, TEK | 2.15298 |
[BP] GO:0007165 | signal transduction | ADORA1, ADORA3, ADRA2A, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 | 2.15005 |
[BP] GO:0070213 | None | TNKS, TNKS2 | 2.14638 |
[BP] GO:0006145 | None | AOX1, XDH | 2.14638 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.14638 |
[BP] GO:1904707 | positive regulation of vascular smooth muscle cell proliferation | MMP2, MMP9, TERT | 2.14151 |
[BP] GO:0030520 | intracellular estrogen receptor signaling pathway | ESR1, ESR2, SRC | 2.14151 |
[BP] GO:0050995 | None | ADORA1, ADRA2A, HCAR2 | 2.14151 |
[BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, EGFR, INSR, SLC6A2, SLC6A4, SMAD3 | 2.13237 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.08603 |
[BP] GO:1904356 | regulation of telomere maintenance via telomere lengthening | AURKB, SRC, TNKS, TNKS2 | 2.08272 |
[BP] GO:0002521 | leukocyte differentiation | AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC | 2.07493 |
[BP] GO:0045859 | regulation of protein kinase activity | ADORA1, ADRA2A, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC | 2.06041 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 | 2.06041 |
[BP] GO:0070301 | cellular response to hydrogen peroxide | AKR1B1, APEX1, AXL, CYP1B1 | 2.06041 |
[BP] GO:0050728 | negative regulation of inflammatory response | ADORA1, CYP19A1, PPARA, SMAD3, TEK | 2.06041 |
[BP] GO:0043406 | positive regulation of MAP kinase activity | ADORA1, ADRA2A, EGFR, FLT3, INSR, PTPN1, SRC | 2.0506 |
[BP] GO:0048729 | tissue morphogenesis | BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 2.04572 |
[BP] GO:0051894 | None | KDR, SMAD3, TEK | 2.04329 |
[BP] GO:0008299 | None | CYP1A1, FDPS, HMGCR | 2.04329 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.04329 |
[BP] GO:0071396 | cellular response to lipid | AXL, CDK6, EGFR, ESR1, FLT3, RORC, SLC6A4, SRC | 2.04234 |
[BP] GO:0031399 | regulation of protein modification process | ADORA1, ADRA2A, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH | 2.0322 |
[BP] GO:0010810 | regulation of cell-substrate adhesion | BCL2, CDK6, KDR, SMAD3, SRC, TEK | 2.00929 |
[BP] GO:0031328 | positive regulation of cellular biosynthetic process | AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A | 2.00836 |
[BP] GO:0048608 | reproductive structure development | AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC | 2.00409 |
[CC] GO:0044432 | endoplasmic reticulum part | BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, F10, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTPN1 | 3.60331 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MMP2, MMP9, PIM1, PTPN1, SLC6A4, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH | 3.11051 |
[CC] GO:0016323 | basolateral plasma membrane | ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK | 2.82204 |
[CC] GO:0005789 | endoplasmic reticulum membrane | BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2 | 2.52754 |
[CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ADRA2A, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR | 2.4501 |
[CC] GO:0005783 | None | ADORA1, APEX1, BCL2, CA4, CES1, CES2, CYP19A1, FLT3, GBA2, HMGCR, HSPA1A, KDR, PTPN1, XDH | 2.4291 |
[CC] GO:0031233 | None | CA4, F10, F3 | 2.23854 |
[CC] GO:0043227 | membrane-bounded organelle | ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH | 2.16841 |
[CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, ADRA2A, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GBA2, GLO1, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT | 2.16251 |
[MF] GO:0046914 | transition metal ion binding | ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH | 17.4877 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 16.4054 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, EGFR, F10, F3, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH | 16.3831 |
[MF] GO:0043167 | ion binding | ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH | 13.753 |
[MF] GO:0016835 | carbon-oxygen lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.3562 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.2872 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3, TNKS | 9.44611 |
[MF] GO:0043169 | cation binding | ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH | 8.97826 |
[MF] GO:0046872 | metal ion binding | ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH | 8.69113 |
[MF] GO:0016829 | lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 | 7.83277 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH | 6.9395 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 6.89038 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 6.35095 |
[MF] GO:0005506 | iron ion binding | ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, XDH | 6.20089 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 6.20089 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH | 5.66285 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TYR | 5.6383 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC | 5.1284 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SLC6A4, SRC, TEK, TOP2A | 5.07779 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19 | 5.04753 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC | 5.04753 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 | 5.01247 |
[MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 4.85693 |
[MF] GO:0004879 | nuclear receptor activity | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 4.85693 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, SRC | 4.78932 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.77002 |
[MF] GO:0005496 | steroid binding | ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC | 4.75978 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK | 4.66566 |
[MF] GO:0048037 | cofactor binding | AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HMGCR, HSD11B2, HSD17B1, SRC, XDH | 4.58345 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, SRC | 4.58326 |
[MF] GO:0003707 | steroid hormone receptor activity | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 4.45079 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK | 4.38746 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19 | 4.26787 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TYR | 4.25782 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, ADRA2A, AXL, CDK6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK | 3.96081 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.92006 |
[MF] GO:0019899 | enzyme binding | ADRA2A, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HMGCR, HSPA1A, KCNH2, MET, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TEK, TNKS2, TOP2A | 3.9125 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK | 3.78611 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK | 3.6098 |
[MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, SMAD3, TEK | 3.53561 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK | 3.37768 |
[MF] GO:0042802 | identical protein binding | ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, HMGCR, IGF1R, KCNH2, KDR, MET, MMP9, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH | 3.34517 |
[MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.2237 |
[MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK, TERT | 3.20314 |
[MF] GO:0008289 | lipid binding | AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC | 3.17865 |
[MF] GO:0004716 | signal transducer, downstream of receptor, with protein tyrosine kinase activity | EGFR, INSR, KDR | 3.15664 |
[MF] GO:0019902 | phosphatase binding | BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 | 3.12889 |
[MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.11983 |
[MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.76832 |
[MF] GO:0003845 | None | HSD11B1, HSD11B2 | 2.76832 |
[MF] GO:0008389 | None | CYP2A13, CYP2A6 | 2.76832 |
[MF] GO:0042803 | protein homodimerization activity | ACHE, ADRA2A, AOX1, BCL2, FLT3, HMGCR, KCNH2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH | 2.54998 |
[MF] GO:0042562 | hormone binding | ACHE, EGFR, HSD17B1, IGF1R, INSR | 2.54998 |
[MF] GO:0016903 | None | AKR1B1, AKR1B10, AOX1, XDH | 2.4985 |
[MF] GO:0008392 | None | CYP2A13, CYP2A6, CYP2C19 | 2.39931 |
[MF] GO:0008391 | None | CYP2A13, CYP2A6, CYP2C19 | 2.39931 |
[MF] GO:0005330 | None | SLC6A2, SLC6A4 | 2.3691 |
[MF] GO:0047374 | None | CES1, CES2 | 2.3691 |
[MF] GO:0140096 | catalytic activity, acting on a protein | AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK | 2.36222 |
[MF] GO:0097159 | organic cyclic compound binding | ADORA1, ADRA2A, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 2.27361 |
[MF] GO:0036094 | small molecule binding | ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH | 2.27361 |
[MF] GO:0046983 | protein dimerization activity | ACHE, ADORA1, ADRA2A, AOX1, AXL, BCL2, EGFR, FLT3, HMGCR, KCNH2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH | 2.25247 |
[MF] GO:0001223 | transcription coactivator binding | ESR1, PPARA, TERT | 2.23854 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, AOX1, CYP19A1, CYP1A2, XDH | 2.16251 |
[MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.14638 |
[MF] GO:0032795 | None | ADORA1, ADRA2A | 2.14638 |
[MF] GO:1901363 | heterocyclic compound binding | ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 2.11643 |
[MF] GO:0019903 | protein phosphatase binding | BCL2, EGFR, HMGCR, MET, PTPN1 | 2.01785 |
[MF] GO:0005518 | collagen binding | ACHE, MMP12, MMP9, SMAD3 | 2.01764 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 | 17.6115 |
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R | 8.6649 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 8.3001 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.5525 |
Metabolic pathways_Homo sapiens_hsa01100 | FDPS, AKR1B1, HMGCR, TYR, CYP2C19, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 | 5.5464 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A | 5.4183 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP2C19 | 5.8404 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R | 4.5635 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 | 4.9666 |
Pathways in cancer_Homo sapiens_hsa05200 | CDK6, SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, IGF1R | 4.1516 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9, EGFR | 4.9658 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | SRC, INSR, KDR, TEK, MET, EGFR, IGF1R | 3.53 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B | 3.4931 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, BCL2, PIM1, F3 | 3.2567 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CDK6, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R | 3.1742 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, AOX1, CYP1B1 | 3.5887 |
Endocytosis_Homo sapiens_hsa04144 | SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A | 3.1229 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | INSR, BCL2, TEK, EGFR, IGF1R | 3.2409 |
Focal adhesion_Homo sapiens_hsa04510 | SRC, KDR, BCL2, MET, EGFR, IGF1R | 2.9172 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, XDH, CES2, CES1 | 3.4355 |
Ras signaling pathway_Homo sapiens_hsa04014 | INSR, KDR, TEK, MET, EGFR, IGF1R | 2.6964 |
Hepatitis B_Homo sapiens_hsa05161 | CDK6, SMAD3, SRC, BCL2, MMP9 | 2.6964 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1, AOX1 | 2.9614 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, CYP1A2, AOX1, CYP2C19 | 2.9172 |
Melanoma_Homo sapiens_hsa05218 | CDK6, MET, EGFR, IGF1R | 2.8887 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 2.9172 |
FoxO signaling pathway_Homo sapiens_hsa04068 | SMAD3, INSR, EGFR, IGF1R | 1.9296 |
Glioma_Homo sapiens_hsa05214 | CDK6, EGFR, IGF1R | 1.9201 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, INSR, ADORA1 | 2.0617 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | INSR, IGF1R, HSPA1A | 1.9252 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | ADORA3, INSR, ADORA1, ADRA2A | 1.6936 |
Pancreatic cancer_Homo sapiens_hsa05212 | CDK6, SMAD3, EGFR | 1.9151 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | SRC, ESR1, ESR2 | 1.8465 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | FLT3, MET, EGFR | 1.9097 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET, EGFR | 1.9045 |
Prostate cancer_Homo sapiens_hsa05215 | BCL2, EGFR, IGF1R | 1.6356 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 1.6236 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2, EGFR | 1.6308 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, INSR, PPARA | 1.4756 |
Serotonergic synapse_Homo sapiens_hsa04726 | ALOX5, CYP2C19, SLC6A4 | 1.4595 |
Toxoplasmosis_Homo sapiens_hsa05145 | ALOX5, BCL2, HSPA1A | 1.4097 |
MAPK signaling pathway_Homo sapiens_hsa04010 | DUSP3, EGFR, CDC25B, HSPA1A | 1.2396 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | ADORA3, BCL2, ADORA1 | 1.3988 |
Measles_Homo sapiens_hsa05162 | CDK6, CSNK2A1, HSPA1A | 1.2797 |
AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, HMGCR, IGF1R | 1.3775 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | SMAD3, ESRRB, IGF1R | 1.2396 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET, EGFR | 1.2144 |
Cell cycle_Homo sapiens_hsa04110 | CDK6, SMAD3, CDC25B | 1.3775 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | GPR35, ADORA3, ADORA1, ADRA2A | 1.1958 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | BCL2, PIM1, AOX1 | 1.1958 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, BCL2, HSPA1A | 0.9931 |
cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, ADORA1, PPARA | 0.9931 |
HTLV-I infection_Homo sapiens_hsa05166 | FDPS, SMAD3, TERT | 0.7967 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE, BCL2 | 0.8551 |
ErbB signaling pathway_Homo sapiens_hsa04012 | SRC, EGFR | 0.9931 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | CDC25B, IGF1R | 0.9385 |
Hepatitis C_Homo sapiens_hsa05160 | PPARA, EGFR | 0.7547 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | CDK6, SMAD3 | 1.0977 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, INSR | 0.7397 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | SRC, ESR1 | 0.8202 |
Small cell lung cancer_Homo sapiens_hsa05222 | CDK6, BCL2 | 0.9931 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, MMP9 | 0.8202 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.7397 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | INSR, IGF1R | 0.965 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.266 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.2747 |
Wnt signaling pathway_Homo sapiens_hsa04310 | SMAD3, CSNK2A1 | 0.734 |
Calcium signaling pathway_Homo sapiens_hsa04020 | EGFR | 0.2711 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | CDK6, EGFR | 1.2272 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | INSR, EGFR | 0.7307 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | BCL2, HSPA1A | 0.6476 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.2204 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | INSR, PPARA | 0.7084 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | SRC | 0.2658 |
Gap junction_Homo sapiens_hsa04540 | SRC, EGFR | 0.9931 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1, TEK | 0.9817 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.0517 |
VEGF signaling pathway_Homo sapiens_hsa04370 | SRC, KDR | 1.1958 |
Influenza A_Homo sapiens_hsa05164 | FDPS, HSPA1A | 0.628 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | SRC, EGFR | 0.6855 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, BCL2 | 0.9678 |
Hippo signaling pathway_Homo sapiens_hsa04390 | SMAD3 | 0.3143 |
Tuberculosis_Homo sapiens_hsa05152 | SRC, BCL2 | 0.6207 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.3217 |
Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.3363 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | SRC, EGFR | 0.5433 |
Viral carcinogenesis_Homo sapiens_hsa05203 | CDK6, SRC | 0.5632 |
Spliceosome_Homo sapiens_hsa03040 | HSPA1A | 0.3474 |
Complement and coagulation cascades_Homo sapiens_hsa04610 | F10, F3 | 1.0479 |
Platelet activation_Homo sapiens_hsa04611 | SRC | 0.3694 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.3619 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | BCL2 | 0.3714 |
Bile secretion_Homo sapiens_hsa04976 | CA2, HMGCR | 1.1133 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.3694 |
Colorectal cancer_Homo sapiens_hsa05210 | SMAD3, BCL2 | 1.1958 |
TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.3978 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.2144 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | SMAD3 | 0.414 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.421 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | EGFR | 0.421 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.421 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | SRC | 0.4218 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.4262 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.4259 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | SMAD3, RORC | 1.1772 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.4382 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, CYP2C19 | 1.1958 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.4435 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.4435 |
TGF-beta signaling pathway_Homo sapiens_hsa04350 | SMAD3 | 0.4533 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.4427 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.4542 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.4895 |
Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.4782 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, INSR | 1.4595 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5065 |
p53 signaling pathway_Homo sapiens_hsa04115 | CDK6 | 0.5084 |
Renal cell carcinoma_Homo sapiens_hsa05211 | MET | 0.5214 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.5258 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.5236 |
Long-term depression_Homo sapiens_hsa04730 | IGF1R | 0.5433 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.6236 |
Tyrosine metabolism_Homo sapiens_hsa00350 | AOX1, TYR | 1.5133 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2, CYP2C19 | 1.6308 |
Legionellosis_Homo sapiens_hsa05134 | HSPA1A | 0.5688 |
Endometrial cancer_Homo sapiens_hsa05213 | EGFR | 0.5867 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.4991 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.5904 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.5791 |
Malaria_Homo sapiens_hsa05144 | MET | 0.6021 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.6064 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | INSR | 0.6062 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 4.9658 |
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | AOX1 | 0.6062 |
Sphingolipid metabolism_Homo sapiens_hsa00600 | GBA2 | 0.6064 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 1.7857 |
Prion diseases_Homo sapiens_hsa05020 | HSPA1A | 0.6946 |
Pyruvate metabolism_Homo sapiens_hsa00620 | GLO1 | 0.6496 |
Dorso-ventral axis formation_Homo sapiens_hsa04320 | EGFR | 0.7547 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.7307 |
Base excision repair_Homo sapiens_hsa03410 | APEX1 | 0.7097 |
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | FDPS, HMGCR | 1.8122 |
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | AOX1 | 0.7397 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.7555 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.734 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.7547 |
Other glycan degradation_Homo sapiens_hsa00511 | GBA2 | 0.8824 |
Folate biosynthesis_Homo sapiens_hsa00790 | ALPL | 0.9678 |
Vitamin B6 metabolism_Homo sapiens_hsa00750 | AOX1 | 1.2144 |