TCM Prescription: Gui Jia Yang Yin Tablets



Prescription Description
Prescription IDTCMF4007
Pinyin NameGui Jia Yang Yin Pian
Chinese Name龟甲养阴片
English NameGui Jia Yang Yin Tablets
Function Description腰痛, 胁痛, 眩晕, 耳鸣, 胸痹
IndicationsHypochondrium pain disorder, Lumbago disorder, Tinnitus disorder, Vertigo disorder, Tinnitus, Chest pain, Dizziness, Lumbago
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ];
SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
MC41 [Tinnitus, 耳鸣 ];
MD30.Z [Chest pain, unspecified, 胸痛，未特指的 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
ME84.2Z [Low back pain, unspecified, 下腰痛，未特指的 ];
Human Tissues Associated with IndicationHeart, Lung, Brain, Kidney, Bladder
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH746 Carapax et plastrum testudinis 龟甲 TCMH746
TCMH611 Rubus idaeus 覆盆子 TCMH611 ITSAE336-14
TCMH178 Carapax trionycis 鳖甲 TCMH178
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH1937 Concha haliotidis 石决明 TCMH1937
TCMH2148 Cuscuta australis 菟丝肉 TCMH2148 ITSAP4209-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH1794 Morus alba 桑葚 TCMH1794 ITSAL1073-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH1321 Os draconis 龙骨 TCMH1321
TCMH1525 Crassostrea gigas 牡蛎 TCMH1525 BCMOL364-12
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2703 Fritillaria unibracteata 紫贝母 TCMH2703 ITSAM1616-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH2610 Concha margaritifera usta;Margarita 珍珠母 TCMH2610
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH693 Cudrania cochinchinensis 狗脊 TCMH693
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT237 SLC5A1 Sodium/glucose cotransporter 1 Transporter P13866
TCMT238 SLC5A2 Sodium/glucose cotransporter 2 Transporter P31639
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT847 SLC5A4 Low affinity sodium-glucose cotransporter Transporter Q9NY91
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, EGFR, ESR1, FABP3, FABP4, FDPS, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 14.0676
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 12.3
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, FABP3, FDPS, FUT7, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 11.0844
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2 11.0416
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2 11.0416
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2 10.8094
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PRKCA, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 10.5601
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.4694
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PPARA, PRKCA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TRPV1, TYR 10.174
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.66343
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, ESR1, FDPS, HSD11B1, HSD17B1, HSD17B2 9.66343
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SRC, TEK, TRPV1, TYR 9.66343
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, EGFR, FABP3, FABP4, FDPS, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 9.44746
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, APP, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTGS1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.18356
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2 8.87721
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TERT, TRPV1 8.86429
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA, PTGS1, PTGS2 8.72075
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TRPV1 8.61547
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2 8.5714
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.56466
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.53387
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.53387
[BP] GO:0007193 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 8.43233
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4, NQO2, PTGS1, RORC 8.02573
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, NR3C1, PPARA, PTGS2, SLC6A4, SRC, TEK, TRPV1 7.98391
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC5A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TRPV1, TYR 7.93466
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 7.65839
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.53598
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TRPV1 7.50406
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 7.4524
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, CHRM5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.41191
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 7.36602
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, CHRM5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.33926
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, NR3C1, PTGS2, RORC, SLC6A4, SRC, TEK, TRPV1, TYR 7.32845
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 7.32551
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 7.30564
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.28216
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 7.26874
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, ALOX12, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT, TRPV1 7.24564
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.2428
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.08616
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 7.0734
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.97799
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.9303
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3, TRPV1 6.91143
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 6.85528
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 6.83514
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, PTGS2, RORC, SLC6A4, SRC, TYR 6.68398
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.61136
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT 6.54655
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TRPV1 6.54655
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 6.44436
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.41438
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.41438
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT 6.36436
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 6.33628
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC, TERT 6.32039
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, INSR, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TRPV1 6.26288
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 6.25702
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, ALOX12, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT 6.2442
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT 6.22015
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 6.13283
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA, PTGS1, PTGS2 6.12995
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 6.11697
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.11697
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, BCL2, CDC25B, CHRM1, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK, TERT 6.04636
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT 6.04636
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, ALOX12, APP, BCL2, CHRM1, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT 6.0006
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2, SLC6A4 5.9616
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2, SLC6A4 5.9616
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 5.94731
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, ALOX12, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT 5.84951
[BP] GO:0007188 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.78147
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TRPV1 5.71995
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, CHRM1, CHRM2, CHRM3, EGFR, GPR35, GRM1, HCAR2, KCNH2, PRKCA, PTGS2, SLC1A1, SMAD3, TRPV1 5.70943
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.70464
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ALOX12, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPR35, GRM1, HCAR2, HSPA1A, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.67926
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 5.58994
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 5.39049
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, FABP4, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.35972
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, ALOX12, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT 5.31151
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 5.27538
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 5.26278
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, NR3C1, PTGS2, RORC, SLC6A4, SRC, TRPV1 5.25923
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 5.25923
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, TRPV1 5.20571
[BP] GO:0007187 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.1994
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK 5.1646
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 5.1646
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CHRM5, CYP1A1, FABP3, FDPS, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 5.10835
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2, PRKCA 5.05921
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, EGFR, FLT3, GRM1, INSR, KDR, PIK3CB, PRKCA, PTPN1, SRC, TEK, XDH 5.04015
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CES1, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 4.9672
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 4.9447
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 4.9447
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK, TRPV1 4.91807
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 4.91807
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EGFR, FDPS 4.89556
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.89556
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SLC6A2, SLC6A4, SMAD3, TRPV1 4.88581
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 4.87256
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, HCAR2, INSR, KCNH2, MMP12, PTGS2, SLC6A4, SMAD3, SRC, TERT, TRPV1 4.85398
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 4.82925
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 4.80017
[BP] GO:0003018 None ADORA1, ADRA2A, CHRM1, CHRM3, EGFR, PTGS2, SLC6A4, SRC, TEK 4.79068
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 4.75378
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 4.70744
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.70479
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 4.66438
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, KDR, PIK3CB, PRKCA, PTPN1, SRC, TEK, XDH 4.66175
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, GRM1, HSPA1A, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 4.59826
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ALOX12, APP, AXL, BCL2, CA2, CHRM3, CYP1B1, EGFR, ESRRB, HCAR2, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PRKCA, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, TRPV1 4.57613
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FDPS, TYR 4.52784
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 4.51716
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 4.49146
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.47981
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EGFR, FDPS 4.43871
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, SRC, TEK 4.41727
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, FDPS, HSD11B1, HSD17B1, HSD17B2 4.41727
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.40054
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 4.39567
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, ALOX12, APP, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.3926
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19, CYP3A4 4.39094
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 4.39094
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 4.39094
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.38414
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.38414
[BP] GO:0007200 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 4.38414
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK 4.35448
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.34292
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 4.32362
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.29894
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.29894
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, PTGS2, SLC6A4, SMAD3, SRC, TRPV1 4.29212
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1, SLC6A2, TEK, TRPV1 4.26234
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 4.24358
[BP] GO:0003008 None ADORA1, ADRA2A, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, EGFR, GRM1, GRM5, GRM8, INSR, KCNH2, PIK3CA, PTGS2, SLC5A1, SLC6A4, SRC, TEK, TRPV1, TYR 4.24358
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.21827
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.21574
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.21574
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.17123
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.13884
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.09194
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.09194
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 4.07
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2, TERT 4.05548
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 4.052
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 4.052
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 4.022
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 3.95883
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, EGFR, HCAR2, KDR, PIK3CB, PTGS2, SRC, TRPV1 3.95617
[BP] GO:0006940 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, PTGS2 3.94536
[BP] GO:0042391 None ADORA1, APP, BCL2, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC, TRPV1 3.94513
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KCNH2, KDR, NR3C1, PTGS2, SLC6A2, SLC6A4, SRC, TRPV1 3.91338
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 3.91277
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 3.91277
[BP] GO:0003013 None ADORA1, ADRA2A, CHRM1, CHRM3, EGFR, PTGS2, SLC6A4, SRC, TEK 3.91092
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 3.89519
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.88835
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 3.88152
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PIK3CB, PTPN1, SRC 3.81924
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 3.81924
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK 3.79215
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.79205
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 3.78953
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX12, ALOX15, BCL2, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.78916
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.78848
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3, TRPV1 3.75725
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR 3.75718
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 3.73905
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 3.73143
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC 3.73143
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, FDPS, TYR 3.72267
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KCNH2, KDR, NR3C1, PTGS2, SRC, TRPV1 3.71356
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.70152
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.70144
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 3.69992
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.69784
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.69784
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, CHRM1, CHRM2, CHRM3, EGFR, KCNH2, PTGS2, SLC1A1 3.68591
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 3.68591
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 3.64251
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.62057
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP3A4 3.62057
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.61642
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH 3.61293
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.59009
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.59009
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, KCNH2, SLC1A1, SLC6A2, TEK 3.57959
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.57307
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.57307
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, EGFR, HSPA1A 3.54279
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, PRKCA, SLC6A4, SRC, TERT 3.52543
[BP] GO:0097746 None ADORA1, ADRA2A, CHRM1, CHRM3, EGFR, PTGS2, SLC6A4 3.50212
[BP] GO:0035296 None ADORA1, ADRA2A, CHRM1, CHRM3, EGFR, PTGS2, SLC6A4 3.50212
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PTGS2, SRC, TEK 3.4823
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.45505
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 3.45475
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.44698
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.44446
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 3.44042
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PTPN1, SMAD3 3.44042
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.42186
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.42186
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR 3.4082
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.39401
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.38632
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.35321
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.35321
[BP] GO:0050880 None ADORA1, ADRA2A, CHRM1, CHRM3, EGFR, PTGS2, SLC6A4 3.35208
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3, TRPV1 3.35208
[BP] GO:0035150 None ADORA1, ADRA2A, CHRM1, CHRM3, EGFR, PTGS2, SLC6A4 3.33309
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.32783
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC, TRPV1 3.30557
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.2873
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.25776
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.25465
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH 3.2534
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 3.22549
[BP] GO:0001775 cell activation ADRA2A, ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, PRKCA, RORC, SMAD3, SRC, TRPV1 3.1973
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA2A, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, PIK3CA, PIK3CB, SRC 3.18309
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, GPR35, KCNH2, MMP9, PTGS2 3.18309
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, SMAD3, SRC, TEK 3.17073
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, EGFR, HCAR2, MET, PIK3CA, PPARA, SMAD3 3.16711
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.16071
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC 3.15836
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.13512
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA, TERT 3.13512
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.11497
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.10308
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.08905
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.08905
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.0787
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.07328
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, KDR, PRKCA, PTPN1, SRC, TEK 3.04956
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC, TRPV1 3.02305
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.00875
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS1, PTGS2 2.99082
[BP] GO:0019229 None ADRA2A, CHRM1, CHRM3, EGFR, PTGS2 2.98887
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.98386
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, KDR, PRKCA, PTGS2, TEK, TERT 2.97294
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, BCL2, CA2, CA7, CHRM1, GPR35, GRM5, KCNH2, MMP9, PTGS2, SLC6A4 2.97294
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 2.96511
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 2.96511
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, NR3C1, PTGS2, SRC 2.95942
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC 2.94387
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, FDPS, PTGS1, PTGS2 2.9387
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.91359
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, NR3C1, PTGS2, SRC 2.91207
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.88093
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.86241
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.84777
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3, TRPV1 2.84777
[BP] GO:0022600 None ADRA2A, CHRM1, CHRM3, CHRM5, SLC5A1 2.84777
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, PRKCA, SRC 2.82625
[BP] GO:0090257 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, PRKCA, PTGS2, SMAD3 2.80091
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.79773
[BP] GO:0009115 None AOX1, XDH 2.77729
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.77729
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.77729
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.77729
[BP] GO:0050730 None ADORA1, ADRA2A, APP, EGFR, FLT3, GRM5, PTPN1, SRC 2.77429
[BP] GO:0015872 None CHRM5, SLC6A2, SLC6A4 2.74801
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.74277
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.711
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, SMAD3, TRPV1 2.6979
[BP] GO:1900543 None ADRA2A, GRM3, GRM8, PPARA, PRKCA 2.68612
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 2.68258
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 2.6788
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, KDR, PRKCA, PTGS2, TEK, TERT 2.66912
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TERT 2.66542
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC, TEK 2.66542
[BP] GO:0045980 None ADRA2A, GRM3, GRM8, PPARA, PRKCA 2.66542
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.66542
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.65493
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.65278
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.65121
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.63064
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.61707
[BP] GO:0061097 None ADORA1, ADRA2A, APP, GRM5, PTPN1 2.61707
[BP] GO:0051234 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, EGFR, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KCNH2, MMP12, MMP9, PPARA, SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 2.6051
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 2.59535
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CES1, CYP1A1, CYP1B1, KDR, SLC6A4, SRC 2.58338
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 2.58309
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2, SLC6A4 2.58029
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.5638
[BP] GO:0038128 None EGFR, PIK3CA, PRKCA, SRC 2.55243
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MMP12, PPARA, PRKCA, PTGS2, SMAD3, TEK 2.52624
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 2.50771
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 2.50476
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 2.49966
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 2.49856
[BP] GO:0051937 None CHRM5, SLC6A2, SLC6A4 2.47808
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.47808
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.47808
[BP] GO:0046683 response to organophosphorus APP, PTGS2, SLC6A4, TEK, TRPV1, TYR 2.47808
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.47567
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APP, AURKB, BCL2, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 2.47567
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 2.46777
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 2.46144
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PTGS2, SRC 2.45564
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, PTGS2, SLC6A4, TRPV1, TYR 2.44231
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.43314
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.43314
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.43147
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 2.41646
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.41126
[BP] GO:0061098 None ADORA1, ADRA2A, GRM5, PTPN1 2.41126
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.41126
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.41126
[BP] GO:0070920 None EGFR, ESR1, TERT 2.41126
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT 2.40654
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, PRKCA, SRC, TEK 2.39932
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.39541
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, CHRM1, EGFR, HCAR2, MMP12, PRKCA, PTGS2, PTPN1, SMAD3, SRC 2.39116
[BP] GO:0030818 None ADRA2A, GRM3, GRM8, PRKCA 2.38927
[BP] GO:0099566 None GRM1, GRM5 2.38927
[BP] GO:0046110 None AOX1, XDH 2.38927
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38927
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.38927
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.38927
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.38424
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.38272
[BP] GO:0051179 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, EGFR, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KCNH2, MMP12, MMP9, PPARA, SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 2.37624
[BP] GO:0042058 None ADORA1, ADRA2A, APP, EGFR, MMP9 2.37012
[BP] GO:0050890 None ADORA1, APP, CHRM1, EGFR, GRM5, INSR, PTGS2, SLC6A4 2.36702
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, NR3C1, PTGS2 2.36558
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC 2.36176
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A4 2.36176
[BP] GO:0030803 None ADRA2A, GRM3, GRM8, PRKCA 2.33224
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.32809
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.32607
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC 2.31475
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, PTGS2, SLC6A4, SMAD3, SRC, TERT 2.31122
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.30339
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC, TRPV1 2.29401
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.27614
[BP] GO:0006810 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KCNH2, MMP12, MMP9, PPARA, SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SRC, TRPV1, XDH 2.27315
[BP] GO:0030815 None ADRA2A, GRM3, GRM8, PRKCA 2.27296
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.27245
[BP] GO:0014074 response to purine-containing compound APP, PTGS2, SLC6A4, TEK, TRPV1, TYR 2.27045
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 2.26357
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, BCL2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 2.24599
[BP] GO:0055065 metal ion homeostasis APP, BCL2, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3, TRPV1 2.24599
[BP] GO:1900372 None ADRA2A, GRM3, GRM8, PRKCA 2.24599
[BP] GO:0030809 None ADRA2A, GRM3, GRM8, PRKCA 2.24599
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.2383
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.22601
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PTGS2, SRC, TEK 2.22239
[BP] GO:0030800 None ADRA2A, GRM3, GRM8, PRKCA 2.21741
[BP] GO:0051172 None ADRA2A, APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, IGF1R, MMP12, MMP9, NR3C1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 2.18969
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.18239
[BP] GO:0040008 regulation of growth ALOX12, APP, BCL2, CSNK2A1, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, SLC6A4, SMAD3 2.18239
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.15801
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.15801
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.14696
[BP] GO:0006145 None AOX1, XDH 2.14696
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.14696
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 2.1398
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.13479
[BP] GO:1901184 None ADORA1, ADRA2A, APP, EGFR, MMP9 2.13479
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MMP12, SLC6A4, SRC, TRPV1 2.13397
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.12866
[BP] GO:0015844 None CHRM5, SLC6A2, SLC6A4 2.12866
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 2.12536
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.1177
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, PIK3CB, PTGS2 2.11404
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.11278
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.11278
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.10547
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.10547
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.10547
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.10547
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK 2.09492
[BP] GO:0006937 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, PTGS2 2.08229
[BP] GO:0035428 None SLC5A1, SLC5A2, SLC5A4 2.08229
[BP] GO:1904659 None SLC5A1, SLC5A2, SLC5A4 2.08229
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.08229
[BP] GO:1905950 None SLC5A1, SLC5A2, SLC5A4 2.08229
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.08229
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.08229
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, PTGS2, SLC6A4, SRC 2.07844
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.07432
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.06505
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 2.06387
[BP] GO:0050877 None ADORA1, APP, CHRM1, CHRM5, CYP1B1, EGFR, GRM1, GRM5, GRM8, INSR, PTGS2, SLC6A4, TRPV1, TYR 2.05957
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 2.0536
[BP] GO:0019725 cellular homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, SMAD3, TRPV1 2.05053
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, SMAD3, SRC, TEK 2.049
[BP] GO:1900542 None ADRA2A, ESRRB, GRM3, GRM8, INSR, PPARA, PRKCA 2.04359
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.04276
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.03503
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.03503
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3, TRPV1 2.0324
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.02854
[CC] GO:0098590 plasma membrane region ADORA1, ADRA2A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, PTGS2, SLC1A1, SRC, TEK, TRPV1 7.29537
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, TEK, TRPV1 7.21214
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PTPN1, SLC1A1, SLC5A1, SLC5A2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 7.18967
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, TEK, TRPV1 6.97009
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DUSP3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KCNH2, KDR, MET, PTGS2, SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SRC, TEK, TRPV1 6.92333
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, EGFR, ESR1, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SLC1A1, SLC5A1, SLC5A2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 5.31336
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 5.27538
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SRC, TEK, TRPV1, TYR 5.26278
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4, SRC, TRPV1 4.8399
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 3.81924
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC6A2, SLC6A4, SRC 3.57307
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, CHRM3, EGFR, TEK 3.35321
[CC] GO:0043235 receptor complex ADRA2A, APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.2873
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, EGFR, FLT3, GRIA2, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 3.17617
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 2.93386
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.84886
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.83214
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, GRIK5, SLC6A4 2.79356
[CC] GO:0097458 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, PTGS1, PTGS2, SLC6A2, SLC6A4, SRC, TRPV1 2.74801
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.64636
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2 2.46144
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 2.42657
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, EGFR, GRIA2, HSD11B1, HSD17B2, PTGS1, PTGS2 2.39116
[CC] GO:0014069 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.39085
[CC] GO:0099572 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.39085
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.38406
[CC] GO:0098589 membrane region APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.33512
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CES1, CES2, CYP19A1, FLT3, GRIK5, HSPA1A, KDR, PRKCA, PTGS2, PTPN1, XDH 2.3064
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, INSR, PTGS1, SRC, TRPV1 2.29506
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, INSR, PTGS1, SRC, TRPV1 2.29506
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GRIA2, GRIA4, GRIK5, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TRPV1, TYR, XDH 2.24599
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TYR, XDH 19.4688
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.5548
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, FDPS, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SRC, TEK, TERT, TYR, XDH 11.0416
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 10.8673
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 10.3499
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.59432
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 9.07645
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 8.77244
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FDPS, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TERT, TRPV1, TYR, XDH 8.77244
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, XDH 8.77244
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 8.7653
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, PPARA, RORC, SMAD3, TEK, TRPV1 8.7653
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PRKCA, PTPN1, RORC, SMAD3 8.72075
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.47985
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FDPS, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TERT, TRPV1, TYR, XDH 8.10407
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 7.60645
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, PTGS1, PTGS2, SRC 7.53598
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.50724
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, SLC6A4, SRC, TEK, TRPV1 7.4718
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, PTGS1, PTGS2, SRC 7.28343
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, PTGS1, PTGS2, TYR 6.8413
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.53607
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, TYR 6.39803
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.38942
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4 6.13283
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.11697
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 6.10419
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 6.10419
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 5.9616
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.81728
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NQO2, NR3C1 5.58994
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, RORC 5.55318
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP3A4 5.43016
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.39049
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.31151
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.1803
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.57613
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.57613
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.52966
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, SRC, TEK 4.49772
[MF] GO:0015370 None SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4 4.369
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.30155
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 4.2164
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK 4.21352
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK 3.74865
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.72836
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, GRIK5, IGF1R, KCNH2, KDR, MET, MMP9, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TRPV1, TYR, XDH 3.70144
[MF] GO:0005412 None SLC5A1, SLC5A2, SLC5A4 3.62057
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 3.59009
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC 3.57307
[MF] GO:0019899 enzyme binding ADRA2A, APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, GRM5, HSPA1A, KCNH2, MET, NR3C1, PPARA, PRKCA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK 3.48927
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TERT 3.46576
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.16071
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 3.13019
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.10308
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.09698
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.09698
[MF] GO:0008227 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5 3.08905
[MF] GO:0015294 None SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4 2.98386
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 2.94387
[MF] GO:0015081 None GRIK5, SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4 2.9301
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.86241
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, KCNH2, TRPV1 2.84777
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.77729
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.77729
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.77729
[MF] GO:0008389 None CYP2A13, CYP2A6 2.77729
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 2.66542
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.59189
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 2.4555
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.38927
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.38927
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.38927
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.38927
[MF] GO:0005330 None SLC6A2, SLC6A4 2.38927
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.38927
[MF] GO:0099583 None GRM1, GRM5 2.38927
[MF] GO:0047374 None CES1, CES2 2.38927
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.36176
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.36176
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.29401
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.27296
[MF] GO:0015293 None SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4 2.27045
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.2383
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.2383
[MF] GO:0016788 None ACHE, ADORA1, ALPL, CA1, CA2, CDC25B, CES1, CES2, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 2.18969
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.1768
[MF] GO:0022890 None GRIA2, GRIA4, GRIK5, KCNH2, SLC1A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, TRPV1 2.16191
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.14696
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.14696
[MF] GO:0004971 None GRIA2, GRIA4 2.14696
[MF] GO:0032795 None ADORA1, ADRA2A 2.14696
[MF] GO:0051425 None APP, INSR 2.14696
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.14696
[MF] GO:0005355 None SLC5A1, SLC5A2, SLC5A4 2.12866
[MF] GO:0015149 None SLC5A1, SLC5A2, SLC5A4 2.08229
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.05053
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.04359
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TYR, XDH 2.02069
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SLC1A1, SRC, TEK, TRPV1, XDH 2.01706


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.687
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GPR35, GRIK5, CHRM5, TRPV1, NR3C1, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 11.486
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.7729
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 8.6284
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4, CYP2C19 9.3634
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, BCL2, PRKCA, PIK3CB 7.0691
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.869
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PRKCA, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 7.0691
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP2C19, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 7.0273
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.1268
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.1268
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 7.0691
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, PRKCA, ALOX12, PTGS2, CYP2C19, PTGS1, SLC6A4 7.0691
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, PIK3CA, BCL2, MET 6.0476
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.8196
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, GRM8, PRKCA, PIK3CB, GRM1, EGFR 6.3116
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12, PTGS2, CYP2C19, PTGS1 6.5337
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, PIK3CA, INSR, KDR, BCL2, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 5.9183
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 6.0114
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, PRKCA, TEK, PIK3CB, EGFR, IGF1R 6.3078
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PRKCA, PIK3CB 5.2446
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 5.2525
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 5.236
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PRKCA, PIK3CB, PTGS2 5.2983
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 4.8668
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PRKCA, PTGS2, MMP9, MET, EGFR, CDC25B 4.821
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, PRKCA, GRM1, EGFR 4.6994
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PRKCA, PIK3CB, MMP9 4.3184
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 4.5714
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PRKCA, ALOX12, PIK3CB, TRPV1 4.2815
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB, EGFR 4.2145
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PRKCA, PTGS2, GRM1, GRIA4 4.2191
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.9031
Glioma_Homo sapiens_hsa05214 PIK3CA, PRKCA, PIK3CB, EGFR, IGF1R 4.0783
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.0885
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PRKCA, PIK3CB 3.9045
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PRKCA, PIK3CB, PTGS2, EGFR 3.296
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 3.923
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.0248
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2, CES1 4.6994
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.9045
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PRKCA, PIK3CB, EGFR 3.5464
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB, ADRA2A 3.1903
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.0783
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.5174
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4, CYP2C19 3.9731
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.0202
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.1444
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, PRKCA, GRM1, EGFR 3.5318
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PRKCA, PIK3CB, ESR1 3.0228
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.0228
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PRKCA, PIK3CB, MMP9 3.0228
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.6975
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.5093
Influenza A_Homo sapiens_hsa05164 FDPS, PIK3CA, PRKCA, PIK3CB, HSPA1A 2.3503
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.1123
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA, EGFR 2.5261
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.432
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PRKCA, PIK3CB, EGFR 3.2115
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.4866
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PRKCA, PIK3CB, EGFR 2.3899
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.121
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.1903
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.2778
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.6112
Long-term depression_Homo sapiens_hsa04730 GRIA2, PRKCA, GRM1, IGF1R 3.1279
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2064
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.215
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2258
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.1123
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.0146
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.0807
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.7575
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2361
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2602
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.001
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.2971
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, PRKCA, EGFR, CDC25B, HSPA1A 1.7642
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 1.9727
HTLV-I infection_Homo sapiens_hsa05166 FDPS, SMAD3, PIK3CA, TERT, PIK3CB 1.7484
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, PRKCA, GRM1 3.0202
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.0202
Axon guidance_Homo sapiens_hsa04360 MET 0.3111
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3186
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.8758
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 1.9017
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.3239
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3775
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6033
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.58
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3954
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6554
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9531
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4139
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1908
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4274
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4114
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4126
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 0.9508
Peroxisome_Homo sapiens_hsa04146 XDH 0.4289
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.0247
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.2992
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.7572
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.4347
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.3033
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7916
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PRKCA, PIK3CB 1.3317
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, PRKCA 1.2874
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.4401
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.45
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, PRKCA, GRIA4 1.3746
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4665
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PRKCA, PIK3CB 1.6919
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.8881
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4761
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.8989
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, PRKCA, GRIA4 1.6712
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 0.9245
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PRKCA, PIK3CB 3.7788
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.4737
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.5955
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PRKCA, PIK3CB 1.6326
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2, PRKCA 1.6633
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PRKCA, PIK3CB 1.6478
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.6919
Morphine addiction_Homo sapiens_hsa05032 ADORA1, PRKCA 0.988
Shigellosis_Homo sapiens_hsa05131 SRC 0.5005
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.001
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5033
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9927
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 1.9385
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.0333
Salivary secretion_Homo sapiens_hsa04970 CHRM3, PRKCA 0.9978
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.0152
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.0029
Insulin secretion_Homo sapiens_hsa04911 CHRM3, PRKCA 1.0247
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, PRKCA, GRIA4 2.0075
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PRKCA, PIK3CB 2.1157
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2, PRKCA 1.927
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.001
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.7442
Bile secretion_Homo sapiens_hsa04976 CA2, SLC5A1, CYP3A4 1.9626
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.1283
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5571
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5571
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.2047
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1462
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.2778
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.58
Mineral absorption_Homo sapiens_hsa04978 SLC5A1 0.58
Malaria_Homo sapiens_hsa05144 MET 0.5867
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5918
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.208
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.3645
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, SLC5A1, PIK3CB 2.432
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2808
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3746
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.3996
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7095
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.7095
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA, ESR1 1.4295
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.752
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7924
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5535
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7698
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8013
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7592
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7418
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7924
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6921
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6476
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6325
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9385
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8665
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0247
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0693
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3371


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)