TCM Prescription: Ge Jie Yang Fei Pills



Prescription Description
Prescription IDTCMF4004
Pinyin NameGe Jie Yang Fei Wan
Chinese Name蛤蚧养肺丸
English NameGe Jie Yang Fei Pills
Function Description咳嗽, 肺痨
IndicationsTuberculosis
Disease ICD-11 Category 1B10.Z [Respiratory tuberculosis, without mention of bacteriological or histological confirmation, 呼吸道结核病，未提及细菌学或组织学证实 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH625 Gecko 蛤蚧 TCMH625
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH1275 Nelumbo nucifera 莲子 TCMH1275 ITSAI3109-14
TCMH2084 Asparagus cochinchinensis 天冬 TCMH2084 ITSAJ4142-14
TCMH710 Trichosanthes kirilowii maxim 瓜蒌子 TCMH710 ITSAO4359-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH2086 Trichosanthes kirilowii 天花粉 TCMH2086 ITSAO4359-14
TCMH273 Fritillaria cirrhosa 川贝母 TCMH273 ITSAP3764-14
TCMH98 Cynanchum stauntonii 白前 TCMH98 GQ434571
TCMH925 Exocarpium citri grandis 化橘红 TCMH925
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH2629 Cortex mori radicis praeparata 桑白皮 TCMH2629
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1090 Brassica juncea 芥子 TCMH1090 ITSAJ4546-14
TCMH2725 Fructus perillae 紫苏子 TCMH2725
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1240 Raphanus sativus 莱菔子 TCMH1240 ITSAD4259-14
TCMH2486 Coix lacryma- jobi var. ma - yuen 薏苡仁 TCMH2486
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH62 Lilium brownii 百合 TCMH62 ITSAO2415-14
TCMH45 Lablab purpureus 白扁豆 TCMH45 ITSAM881-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH147 Glehnia littoralis 北沙参 TCMH147 ITSAF389-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH72 Bletilla striata 白芨 TCMH72 ITSAJ4380-14
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT953 PNMT Phenylethanolamine N-methyltransferase Transferase P11086


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1174 Mycobacterium bovis BCG
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1184 Mycobacterium fortuitum
TCMT1185 Mycobacterium phlei
TCMT1186 Plasmodium yoelii yoelii
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1192 Bacteria
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1196 Salmonella
TCMT1198 Serratia marcescens
TCMT1199 Streptococcus sp. 'group A'
TCMT1200 Bacillus thuringiensis
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1202 Mycoplasma hominis
TCMT1203 Mycoplasma pneumoniae
TCMT1204 Clostridium perfringens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1216 Vibrio cholerae
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1220 Streptococcus pneumoniae R6
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1244 Staphylococcus saprophyticus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1252 Alcaligenes faecalis
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1262 Mycoplasma putrefaciens
TCMT1266 Mycobacterium abscessus
TCMT1267 Mycobacterium chelonae
TCMT1271 Shigella flexneri
TCMT1272 Campylobacter jejuni
TCMT1273 Pseudomonas putida
TCMT1274 Shigella boydii
TCMT1276 Klebsiella
TCMT1277 Serratia
TCMT1278 Pseudomonas
TCMT1281 Clostridium difficile
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1287 Bacillus subtilis subsp. spizizenii ATCC 6633
TCMT1289 Shigella dysenteriae
TCMT1290 Acinetobacter calcoaceticus
TCMT1291 Haemophilus parainfluenzae
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1299 Morganella morganii
TCMT1300 Enterobacter
TCMT1301 Klebsiella sp.
TCMT1303 Bacillus
TCMT1304 Staphylococcus capitis
TCMT1305 Salmonella enteritidis
TCMT1307 Penicillium marneffei
TCMT1309 Aspergillus clavatus
TCMT1310 Enterococcus hirae
TCMT1314 Streptococcus viridans
TCMT1315 Streptococcus sp.
TCMT1317 Staphylococcus lentus
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1326 Shigella
TCMT1331 Acinetobacter sp.
TCMT1332 Bacillus licheniformis
TCMT1334 Chlamydia trachomatis
TCMT1340 Staphylococcus faecalis
TCMT1341 Streptococcus oralis
TCMT1342 Streptococcus salivarius
TCMT1345 Prevotella loescheii
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1356 Campylobacter coli
TCMT1358 Bacteroides vulgatus
TCMT1361 Neisseria meningitidis
TCMT1362 Bordetella pertussis
TCMT1363 Peptostreptococcus anaerobius
TCMT1366 Prevotella bivia
TCMT1371 Veillonella parvula
TCMT1375 Clostridium tetani
TCMT1377 Staphylococcus lugdunensis
TCMT1378 Acinetobacter haemolyticus
TCMT1381 Listeria innocua
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1383 Streptomyces griseus
TCMT1388 Prevotella disiens
TCMT1389 Klebsiella oxytoca
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1394 Mycobacterium aurum
TCMT1395 Staphylococcus sp.
TCMT1396 Fusobacterium
TCMT1399 Chlamydophila pneumoniae
TCMT1400 Mycobacterium mageritense
TCMT1401 Staphylococcus warneri
TCMT1402 Staphylococcus cohnii
TCMT1403 Streptococcus constellatus
TCMT1404 Streptococcus intermedius
TCMT1406 Mycobacterium leprae
TCMT1407 Aeromonas punctata
TCMT1408 Colletotrichum gloeosporioides
TCMT1409 Escherichia coli O157:H7
TCMT1410 Listeria monocytogenes
TCMT1411 Vibrio parahaemolyticus
TCMT1412 Salmonella typhimurium
TCMT1413 Vibrio splendidus
TCMT1414 Vibrio vulnificus
TCMT1415 Vibrio fluvialis
TCMT1416 Plesiomonas shigelloides
TCMT1417 Aeromonas sobria
TCMT1418 Enterobacteriaceae
TCMT1420 Klebsiella pneumoniae subsp. ozaenae
TCMT1421 Vibrio mimicus
TCMT1422 Clostridium histolyticum
TCMT1423 Peptostreptococcus
TCMT1424 Haemophilus ducreyi
TCMT1425 Moraxella bovis
TCMT1427 Proteus inconstans
TCMT1429 Acinetobacter pittii
TCMT1431 Coxiella burnetii
TCMT1432 Serratia sp.
TCMT1434 Plesiomonas
TCMT1435 Corynebacterium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PPARA, PPARD, TRPV1 11.759
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PPARD, RORC, SRC, TRPV1, TYR 10.2992
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, KDR, MET, MIF, PPARA, PPARD, SLC1A1, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 10.1096
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARD 9.5286
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.89193
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, PPARA, PPARD, RORC, SRC, TRPV1, TYR 8.28064
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PPARD, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 8.16791
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARD, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 8.16791
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.71432
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MIF, MMP9, PIM1, PPARD, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 7.60885
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PPARD, RORC, SRC, TERT, TRPV1, TYR 7.45544
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 7.32103
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PPARD, RORC, SRC, TYR 7.18839
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, GLO1, HMGCR, MIF, PIM1, PPARA, PPARD, TYR, XDH 7.18839
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.96699
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HTR1A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARD, SRC, TERT, XDH 6.9634
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, F3, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.90881
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, F3, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.88372
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, MIF, PPARA, PPARD 6.84283
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, PPARD 6.82355
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, ESR1, F3, FLT3, HMGCR, HTR1A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARD, TERT 6.69785
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.57874
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.4989
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.4989
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.46186
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, FLT3, HSD11B2, RORC, SRC, TRPV1, TYR 6.44298
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD2, HCAR2, HMGCR, KDR, MIF, SRC, TNKS, TNKS2, TRPV1 6.38153
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARD, TYR, XDH 5.92188
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, HTR1A, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, RORC, SRC, TNKS2, TRPV1, TYR 5.82025
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.72939
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC, TERT 5.67403
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 5.60942
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PPARD, PTPN1, SRC, TERT 5.56101
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.56101
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HMGCR, MIF, SRC, TNKS, TNKS2, TRPV1 5.53869
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, SRC, TRPV1 5.48637
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 5.41559
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARD, PTPN1, SRC, TERT 5.41559
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, SRC, TRPV1 5.37485
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA, PPARD, SLC1A1, TRPV1 5.3033
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, F3, GRIK5, GRM5, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, SRC, TERT, TRPV1 5.29214
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, PPARD, RORC, SRC, TERT, TRPV1 5.26853
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.18338
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 5.18338
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, PPARD, RORC, SRC, TERT, TNKS2, TOP2A, TYR 5.16582
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MIF, MMP1, MMP2, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.15218
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, GRM1, HMGCR, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.15205
[BP] GO:0007193 None ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A 5.09542
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, F3, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC, TERT 5.03765
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.01232
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PPARD 5.01232
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, BACE1, CA2, CA7, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8 4.94973
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, BACE1, CA2, CA7, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8 4.94973
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, PPARD, RORC, SRC 4.94119
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 4.90775
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.89482
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, HTR1A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1, TYR 4.89482
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MIF, MMP9, PIM1, PPARD, PTPN1, SRC, TERT 4.85557
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, TRPV1 4.82757
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MIF, MMP2, MMP9, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1 4.81538
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC, SRC 4.80874
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.7922
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, PPARD, RORC, SRC, TRPV1 4.7922
[BP] GO:0032787 None ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, MIF, PPARA, PPARD 4.77541
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, F3, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC, TERT 4.72495
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, F3, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC, TERT 4.64921
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, F3, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC, TERT 4.63312
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PPARD, SRC, TERT 4.62158
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD2, GBA2, HMGCR, HTR1A, PPARD, TYR 4.58215
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.58215
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PPARD, SRC, TERT 4.51699
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8 4.48355
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, PPARD, SRC, XDH 4.43069
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.40451
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.36643
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, PPARD, SRC, TYR 4.3174
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 4.30707
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.27446
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD2, FABP3, HMGCR, HSD11B2, KDR, SRC, TRPV1 4.27288
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESRRA, F3, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MIF, MMP12, MMP2, MMP9, PPARD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.27196
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.26804
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.22569
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PPARD, SRC, TERT 4.22338
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA, PPARD, SLC1A1, TRPV1 4.22338
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1 4.22245
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, GRM1, HMGCR, KDR, MET, MIF, PPARD, PTPN1, SRC, XDH 4.17704
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PPARD, RORC, SRC, TRPV1 4.1752
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PPARD 4.1709
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD2, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC, TERT, TRPV1 4.12951
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC, SRC 4.11511
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.09235
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.06714
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD2, GRM1, HMGCR, HSD11B2, MMP2, PPARA, PPARD, SRC, TERT, TRPV1, TYR 4.04149
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, BCL2, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 3.974
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD2, HMGCR, KDR, SRC 3.91768
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.90817
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.85126
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, MIF, PPARD 3.65924
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2, PPARD 3.59866
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, MIF, PIM1, PPARA, PPARD, TYR 3.53961
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, MIF, PPARD 3.47818
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD2, KDR, SRC, TRPV1 3.47446
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.4538
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.4538
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, MIF, PIM1, PPARD, SRC, TYR 3.44425
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, PPARA, RORC, SRC, TOP2A 3.44309
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PPARD, PTPN1, SRC, XDH 3.43806
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.41055
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.39162
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, MIF, PPARD 3.30833
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AURKB, BCL2, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 3.30419
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, DRD2, GRIK5, GRM5, HCAR2, HMGCR, HTR1A, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, SRC, TERT, TRPV1 3.30419
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, HCAR2, MIF, MMP12, PPARD, SRC, TRPV1 3.30139
[BP] GO:0007188 None ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A 3.30139
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.24913
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 3.23708
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.23408
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.23336
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DRD2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 3.21506
[BP] GO:0040013 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, MIF, PPARD 3.1818
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DRD2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 3.16584
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CYP19A1, DRD2, ESR1, F3, FABP4, HMGCR, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PPARD, PTPN1, SRC, TERT, XDH 3.16364
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.16087
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.15513
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.15513
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.14979
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, MIF, PIM1, PPARA, PPARD, TYR 3.11181
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, DRD2, ESR1, ESR2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, SRC, TERT, XDH 3.09007
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.04743
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 3.04495
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, GRM1, HCAR2, HMGCR, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARD, SLC1A1, SRC, TERT, TNKS2, TRPV1, XDH 3.03462
[BP] GO:0006082 organic acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, MIF, PIM1, PPARA, PPARD, TYR 3.03425
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.02617
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.02617
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, HMGCR, IGF1R, MET, MIF, MMP9, PTPN1, SRC, XDH 3.01812
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, PPARD, SRC, TERT 3.01812
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, GRIK5, HCAR2, HMGCR, HTR1A, MIF, MMP12, PPARD, SRC, TRPV1 3.01055
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PPARD, PTPN1, SRC, TNKS, XDH 3.01055
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DRD2, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PTPN1, SRC, XDH 3.00584
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DRD2, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PTPN1, SRC, XDH 3.00584
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.00004
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, PPARA, PPARD 2.99818
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 2.97383
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.97383
[BP] GO:0002793 None ACHE, ADORA1, DRD2, HCAR2, MIF, MMP12, PPARD, SRC 2.95823
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CDK6, CYP1A1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, KDR, MET, MIF, MMP2, MMP9, PPARD, RORC, SRC, TERT, TOP2A 2.94704
[BP] GO:0007187 None ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A 2.94698
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD2, ESRRB, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.94467
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F3, HCAR2, HMGCR, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC1A1, SRC, TERT, TRPV1 2.94215
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HMGCR, HSD11B2, PPARD, SRC, TRPV1, TYR 2.94111
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.93597
[BP] GO:0051172 None APEX1, AURKB, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.88222
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD2, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 2.87999
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR, PPARD 2.87318
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GRM5, HSD11B2, IGF1R, PPARA, SRC, TRPV1 2.86751
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, ESR1, FLT3, RORC, SRC, TRPV1 2.84992
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PPARD, TERT 2.82081
[BP] GO:0045934 None APEX1, AURKB, DRD2, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, MMP12, PPARA, PPARD, RORC, SRC, TERT, TNKS, TNKS2, TRPV1 2.80294
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, TERT 2.80294
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.78605
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD2, ESR1, F3, FABP4, HMGCR, KDR, MET, MIF, MMP12, PPARA, PPARD 2.77198
[BP] GO:0009115 None AOX1, XDH 2.77198
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, HTR1A, TYR 2.76847
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PPARD, PTPN1, SRC, TNKS, XDH 2.76622
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC 2.76523
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.74042
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, SRC, TRPV1 2.70599
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, GRIK5, HCAR2, HMGCR, HTR1A, MIF, MMP12, PPARD, SRC 2.6993
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 2.69256
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.69256
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF 2.68039
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, PPARD, RORC, SRC, TYR 2.65446
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.65446
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.62682
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, DRD2, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, TRPV1 2.59967
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD2, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 2.59466
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.59332
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.57011
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD2, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 2.56875
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PPARA, PPARD, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 2.56565
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.56241
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MIF, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.54623
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, DRD2, HCAR2, MIF, MMP12, PPARD, SRC, TERT, TRPV1 2.52142
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.49444
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, SRC, TOP2A, TRPV1, XDH 2.49444
[BP] GO:0042391 None ADORA1, BCL2, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 2.48366
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TRPV1, XDH 2.4773
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PPARA, PPARD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.4736
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, HCAR2, TNKS, TNKS2 2.46456
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, SRC, TOP2A, TRPV1, XDH 2.46456
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, HMGCR, HSD11B2, PPARD, SRC, TRPV1, TYR 2.45059
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.42516
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, DRD2, FLT3, GRM1, HMGCR, KDR, MIF, PTPN1, SRC, XDH 2.42505
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTPN1, SRC 2.42247
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, MIF, TERT 2.4195
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.40747
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, TERT 2.39271
[BP] GO:0099566 None GRM1, GRM5 2.38481
[BP] GO:0046110 None AOX1, XDH 2.38481
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38481
[BP] GO:0050714 None ACHE, DRD2, HCAR2, MIF, MMP12, PPARD, SRC 2.38405
[BP] GO:0042752 None ADORA1, DRD2, PPARA, RORC, TOP2A 2.37622
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.37266
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD2, ESR1, ESR2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.3494
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.33913
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD2, ESR1, ESR2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.33657
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.32421
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, MIF, PTPN1, SRC, TNKS 2.32335
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, GRM1, GRM5, MET, MIF, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.31387
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.31387
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARD, SLC1A1, TRPV1 2.28805
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.28735
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, PPARD 2.24833
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.24769
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.23908
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, GRM1, HMGCR, IGF1R, MIF, PTPN1, SRC 2.2359
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, MIF, PTPN1, SRC 2.22951
[BP] GO:0044242 None AKR1B10, CYP1B1, FABP3, FABP4, GBA2, PPARD 2.22951
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, SRC, TOP2A, TRPV1, XDH 2.22951
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, PPARD 2.22739
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, PPARA, PPARD, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 2.21909
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 2.21854
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, GRIK5, HTR1A, SLC1A1, TRPV1 2.20205
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, MIF, PTPN1, SRC 2.19821
[BP] GO:0002791 None ACHE, ADORA1, DRD2, HCAR2, HMGCR, MIF, MMP12, PPARD, SRC 2.15527
[BP] GO:0090344 None CDK6, MIF, TERT 2.1509
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.1509
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.1509
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.1509
[BP] GO:0070213 None TNKS, TNKS2 2.1483
[BP] GO:0006145 None AOX1, XDH 2.1483
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.1483
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, HCAR2, HMGCR, HTR1A, PPARD 2.14041
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, HTR1A 2.13935
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, HCAR2, MIF, MMP12, PPARD, SRC 2.1344
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.1299
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PPARD, SRC, TOP2A 2.1299
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, GRM1, GRM5, MIF, PTPN1, SRC, TNKS 2.12904
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, PPARA, PPARD, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.12731
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.12731
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.11483
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.10338
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.10158
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD2, MET, TRPV1 2.07395
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.06903
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.06801
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.06297
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.04639
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, MIF, SRC, TERT 2.03693
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.03693
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, HMGCR, PPARD, TRPV1, TYR 2.02879
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.01922
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.01856
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD2, HMGCR, MIF, PPARA, PPARD 2.01856
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.01174
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPI, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TERT, TNKS, TNKS2, TRPV1, TYR 3.91768
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPI, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD2, ESR1, F3, FLT3, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TERT, TRPV1 3.75707
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC, TRPV1 3.53653
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, BACE1, CA4, DRD2, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, SLC1A1, TRPV1 3.15277
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.15272
[CC] GO:0044432 endoplasmic reticulum part BACE1, BCL2, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.80102
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.77198
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.77198
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 2.66103
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPI, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR1A, IGF1R, KDR, MET, PTPN1, SLC1A1, SRC, TRPV1, TYR 2.65741
[CC] GO:0044456 None ACHE, ADORA1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 2.63412
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, BACE1, DRD2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, SLC1A1, TRPV1 2.4195
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2 2.19064
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CES2, CYP19A1, FLT3, GBA2, GRIK5, HMGCR, KDR, PTPN1, XDH 2.11483
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, BACE1, CA2, CA4, CA9, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, IGF1R, KDR, MET, SLC1A1, SRC, TRPV1 2.07908
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.07395
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.04639
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, TNKS, TYR, XDH 15.0265
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.47931
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.17505
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 9.13684
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PPARD, PTPN1, RORC, TNKS 7.91023
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.72443
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, KDR, MET, PPARA, PPARD, RORC, TRPV1 7.67311
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, ESR2, ESRRA, ESRRB, GLO1, HTR1A, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC1A1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 7.22684
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, KDR, MET, PPARA, PPARD, RORC, TRPV1 7.12752
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, KDR, MET, PPARA, PPARD, RORC, TRPV1 6.78069
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 6.42632
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.38153
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.34397
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 6.2472
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 6.2472
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, KDR, MET, PPARA, PPARD, RORC, TRPV1 6.0212
[MF] GO:0046872 metal ion binding ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC1A1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 5.98287
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.92188
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 5.72939
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.71599
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.19732
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.01232
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.80449
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.80207
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.55757
[MF] GO:0030594 None DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A 4.21422
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, KDR, MET, TRPV1 4.04149
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, IGF1R, KDR, MET, TRPV1 4.04149
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, PPARD, RORC, TRPV1 4.00128
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.99883
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B2, HSD17B1, SRC, XDH 3.98874
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.8084
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.74841
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.60172
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.30833
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, PPARD, SRC, TOP2A, TRPV1 3.24851
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.23336
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.15272
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.13707
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, DRD2, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MIF, MMP9, TERT, TOP2A, TRPV1, TYR, XDH 3.10536
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.91721
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.77198
[MF] GO:0003845 None HSD11B1, HSD11B2 2.77198
[MF] GO:0008389 None CYP2A13, CYP2A6 2.77198
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.74747
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.54635
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.42448
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.42192
[MF] GO:0099583 None GRM1, GRM5 2.38481
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.31387
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.31387
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.24931
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.21275
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.18042
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.1483
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.1483
[MF] GO:0004971 None GRIA2, GRIA4 2.1483
[MF] GO:0008134 transcription factor binding APEX1, BCL2, ESR1, ESRRB, FLT3, PIM1, PPARA, PPARD, SRC, TERT 2.02343
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.01856


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.4851
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.2909
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.4217
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, HTR1A, TRPV1, DRD2, GRM1, GRIA4 7.4217
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.3078
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, ALPI, XDH 4.6992
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.961
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.3997
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.7849
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.7703
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, HTR1A, DRD2, PPARA, GRIA4 3.794
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R, PPARD 3.6271
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.8554
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 3.9674
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.7272
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 2.8601
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.712
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.969
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.342
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.342
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1 2.5289
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.143
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.1068
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 1.9255
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.9215
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1, PPARD 2.1068
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.5696
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2 2.2343
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.0582
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2 2.2971
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.9535
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9158
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9108
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6465
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 1.3994
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 1.9255
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2032
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD2, GRIA4 1.3094
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.3837
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1412
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.8595
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.8925
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.919
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 0.959
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9087
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.184
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 0.8788
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.1064
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1412
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8788
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.8894
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.0981
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.9385
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.8536
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.0981
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.8219
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0003
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8294
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.8989
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7791
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1505
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, HTR1A 0.821
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.0941
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7994
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7994
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.7994
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.0673
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.7796
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.7414
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7364
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7796
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.2421
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7321
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PPARD 0.7321
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7321
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.1923
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1924
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1 0.6036
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.637
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5482
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6068
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2359
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5427
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2623
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2688
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2778
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2871
Alcoholism_Homo sapiens_hsa05034 DRD2 0.2756
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2686
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.2871
Parkinson's disease_Homo sapiens_hsa05012 DRD2 0.3266
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3018
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3164
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3131
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3281
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3281
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3386
Platelet activation_Homo sapiens_hsa04611 SRC 0.3583
Axon guidance_Homo sapiens_hsa04360 MET 0.3508
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3601
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3583
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4038
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3868
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4135
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4133
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4342
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4254
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.425
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4247
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4336
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4342
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4342
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4342
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4342
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4342
Peroxisome_Homo sapiens_hsa04146 XDH 0.4421
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4786
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4567
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4773
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4907
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6142
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5053
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4923
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5053
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5053
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5053
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5053
Shigellosis_Homo sapiens_hsa05131 SRC 0.5053
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5053
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4817
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5053
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5363
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5704
Malaria_Homo sapiens_hsa05144 MET 0.5758
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5835
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5795
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5835
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6354
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.819
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6299
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7144
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6938
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7321
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7321
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7414
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7231
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.1162
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7364
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.8435
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.7833
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8294
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1466


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)