TCM Prescription: Dan Xiang Bi Yan Tablets



Prescription Description
Prescription IDTCMF3994
Pinyin NameDan Xiang Bi Yan Pian
Chinese Name胆香鼻炎片
English NameDan Xiang Bi Yan Tablets
Function Description鼻渊
IndicationsNasal sinusitis disorder
Disease ICD-11 Category SC91 [Nasal sinusitis disorder (TM1), 鼻渊 (TM1) ];
Human Tissues Associated with IndicationNose
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2695 NA 猪胆 TCMH2695
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH206 Fructus xanthii sibirici 苍耳子 TCMH206 KJ496390
TCMH536 Centipeda minima 鹅不食草 TCMH536 ITSAJ4316-14
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH2452 Chrysanthemum indicum 野菊花 TCMH2452 ITSAB1463-14
TCMH189 Mentholum 薄荷脑 TCMH189
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1184 Mycobacterium fortuitum
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1261 Pseudomonas savastanoi pv. savastanoi
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1352 Colletotrichum truncatum
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1394 Mycobacterium aurum
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, KIT, MET, PPARA 9.47549
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TYR, XDH 8.03767
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FUT7, HMGCR, PIM1, PPARA, TYR, XDH 7.72707
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HMGCR, HSD17B1, HSD17B2 7.10584
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TYR 6.88897
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TYR, XDH 6.66118
[BP] GO:0010033 response to organic substance AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, KIT, MMP2, NR3C1, PPARA, RORC, SRC, TYR 6.61899
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TYR 6.58273
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PGR, PIM1, SRC, XDH 6.58273
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TYR 6.46784
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC 5.81788
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HMGCR, KIT, MET, PPARA 5.77483
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.77483
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, XDH 5.77483
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, XDH 5.77483
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, SRC 5.77483
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SRC, XDH 5.57273
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC 5.57273
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 5.1369
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SRC, XDH 4.98009
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, XDH 4.88125
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSD17B2, KDR, KIT, MET, PPARA, SRC, XDH 4.81359
[BP] GO:0033993 response to lipid AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR 4.81359
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, HMGCR, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PGR, PIM1, PPARA, RORC, SRC, TYR 4.77863
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TYR, XDH 4.72555
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.72555
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TYR, XDH 4.72555
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.70408
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HMGCR, HSD17B1, HSD17B2, TYR, XDH 4.69333
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 4.67499
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.55089
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, RORC, SRC 4.37581
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, FLT3, HMGCR, KDR, KIT, MET, PTPN1, SRC, XDH 4.29513
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, XDH 4.27441
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, KIT, MMP2, NR3C1, PPARA, SRC 4.27441
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 4.14154
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 4.14154
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, KIT, PPARA, SRC, TYR 4.13958
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A6 4.06166
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 4.06166
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, FABP4, HMGCR, HSD17B2, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR 4.06166
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, NR3C1, RORC, SRC, TYR 4.05894
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AR, AXL, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, NR3C1, RORC, SRC 4.03688
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1 4.02704
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 4.02704
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 4.02704
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, XDH 3.99172
[BP] GO:0030522 intracellular receptor signaling pathway AR, NR3C1, PGR, PIM1, PPARA, RORC, SRC 3.97702
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HMGCR, KIT, PPARA, RORC, SRC 3.96412
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.96236
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.90452
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.85148
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.84166
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 3.83981
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TYR 3.83981
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.81226
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, HMGCR, KDR, KIT, PTPN1, SRC, XDH 3.76645
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 3.72643
[BP] GO:0009725 response to hormone AKR1B1, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, KIT, NR3C1, PPARA, SRC 3.68631
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, SRC 3.67355
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PPARA 3.65188
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP2, MMP9, PTPN1, SRC, XDH 3.64607
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.59997
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, KDR, KIT, MMP9, PGR, PIM1, PPARA, RORC, SRC, TYR 3.51038
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, HMGCR, IGF1R, KDR, KIT, PTPN1, SRC, XDH 3.36916
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.32993
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC 3.17825
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 3.17628
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.168
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, FLT3, NR3C1, RORC, SRC 3.16294
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.14837
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.14837
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR3C1, NR3C2, PGR, PPARA, RORC 3.12004
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.12004
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC 3.12004
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PTPN1, RORC, SRC 3.12004
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.11489
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 3.11009
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.08868
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 3.03903
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 3.03831
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.03831
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, XDH 3.03404
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, XDH 3.01617
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 3.01384
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HMGCR, HSD17B1, HSD17B2 2.98074
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, FLT3, KIT, MET, PIM1, SRC, TYR 2.97392
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.96937
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 2.96145
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, CDC25B, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.94544
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC 2.92879
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.90629
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, HMGCR, KIT, MMP2, PPARA, SRC, TYR 2.90119
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.89502
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, XDH 2.89137
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, KIT, PGR, PPARA, RORC, SRC 2.87828
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, CDC25B, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, XDH 2.85462
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.85299
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, XDH 2.82476
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, HMGCR, TYR 2.78868
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA 2.76156
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SRC, XDH 2.72166
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.67196
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC 2.66907
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.66907
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC 2.66498
[BP] GO:0006352 DNA-templated transcription, initiation AR, NR3C1, NR3C2, PGR, PPARA, RORC 2.66498
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.66498
[BP] GO:0048869 cellular developmental process ACHE, APP, AR, AXL, CBR1, CDC25B, CYP1A1, FABP4, FLT3, FUT7, HMGCR, KDR, KIT, MET, MMP2, MMP9, PGR, RORC, SRC 2.63549
[BP] GO:0042493 response to drug ABCG2, AKR1B1, AXL, CYP1A1, CYP1B1, FABP3, HMGCR, KDR, NR3C1, SRC 2.62673
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC 2.6184
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9 2.60085
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.59035
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.57651
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.57166
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, FLT3, FUT7, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TYR, XDH 2.57109
[BP] GO:0060748 None AR, PGR 2.55581
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.55581
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, XDH 2.53303
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.47605
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.44874
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.42108
[BP] GO:0050730 None ADORA1, APP, FLT3, KIT, PTPN1, SRC 2.42075
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PPARA 2.41408
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.41408
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.41408
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PIM1, PPARA, TYR 2.41408
[BP] GO:0022414 reproductive process AKR1B1, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, HSD17B2, KIT, MMP2, MMP9, PGR, SRC 2.40583
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.40531
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, MET, SRC 2.40021
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.3902
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.34
[BP] GO:0006793 phosphorus metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, XDH 2.33117
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.32251
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.31349
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.31349
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.30802
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9 2.26483
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, CDC25B, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.25403
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.25403
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.25214
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, NR3C1, PGR, SRC 2.23249
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.21547
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.21547
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.19922
[BP] GO:0002521 leukocyte differentiation AXL, FLT3, FUT7, KIT, MMP9, RORC 2.18978
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, FLT3, IGF1R, KIT, MMP2, NR3C1, SRC 2.18443
[BP] GO:1901655 None AKR1B1, AR, NR3C1, SRC 2.18443
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.18443
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 2.1814
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PIM1, PPARA, TYR 2.17265
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TYR, XDH 2.16372
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.15445
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.15445
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.14331
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, XDH 2.14331
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, HSD17B2, KIT, SRC 2.13526
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, FABP4, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, XDH 2.13128
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA 2.11132
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.11132
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, HMGCR, KDR, SRC 2.10181
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, XDH 2.09436
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.09436
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, KIT, PGR, SRC 2.09436
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2 2.08411
[BP] GO:0021700 developmental maturation APP, AXL, CDC25B, MMP2, PGR 2.08031
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, KIT, PTPN1, SRC 2.07046
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.06663
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, NR3C1, SRC 2.06472
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.06472
[BP] GO:1901654 None AKR1B1, AR, CSNK2A1, NR3C1, SRC 2.02216
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, KDR, KIT, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, SRC, TYR, XDH 2.92167
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.0139
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.81009
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FLT3, FUT7, HMGCR, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, NR3C2, PGR, PIM1, PTPN1, SRC, TYR 1.70326
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FLT3, HMGCR, HSD17B2, NR3C2, PTPN1 1.56719
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, TYR, XDH 14.9204
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TYR, XDH 9.47549
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TYR, XDH 8.34477
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.32594
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC 6.66118
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HMGCR, HSD17B1, HSD17B2, TYR, XDH 5.57273
[MF] GO:0043169 cation binding ACHE, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, TYR, XDH 5.31714
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.31714
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 5.31714
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, PPARA, RORC 5.15713
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.05471
[MF] GO:0046872 metal ion binding ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, TYR, XDH 4.91629
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.69333
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.58019
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, XDH 4.55946
[MF] GO:0005496 steroid binding AR, HSD17B1, NR3C1, NR3C2, PGR, RORC 4.38652
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TYR 4.17124
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, XDH 4.14646
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.96412
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.90452
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2 3.76645
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC 3.67501
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, SRC 3.61747
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, SRC 3.44122
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1 3.19679
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TYR 3.17628
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HMGCR, HSD17B1, SRC, XDH 3.12004
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.98074
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.97601
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.95075
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC 2.92167
[MF] GO:0008289 lipid binding AR, AXL, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC 2.89137
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, PGR, PPARA, RORC 2.89137
[MF] GO:0004879 nuclear receptor activity AR, PGR, PPARA, RORC 2.89137
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.89137
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC 2.43357
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.42358
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.40531
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC 2.32251
[MF] GO:0042802 identical protein binding ABCG2, ACHE, APP, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PGR, TYR, XDH 2.26062
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.17887
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.12198
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.09436
[MF] GO:0036094 small molecule binding ABCG2, ADORA1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.08967
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC 2.0884
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A6 2.03335
[MF] GO:0004064 arylesterase activity CA1, CA2 2.0139


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.6772
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.5993
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.5955
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, HMGCR, TYR, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 4.667
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1 4.667
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.667
Pathways in cancer_Homo sapiens_hsa05200 AR, FLT3, MMP1, MMP2, KIT, MMP9, MET, IGF1R 4.1708
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.9307
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1 4.5651
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.3754
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.5914
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 2.8277
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.4756
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.9158
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.5193
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3717
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 2.3039
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.392
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.4057
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.0884
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.2333
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, ABCG2 2.3418
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.9606
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 2.0439
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.0439
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.8499
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.7932
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KIT, KDR, MET, IGF1R 1.4815
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.5168
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4815
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.1762
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4861
Prostate cancer_Homo sapiens_hsa05215 AR, IGF1R 1.2491
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4029
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2411
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, NR3C1 1.1209
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4163
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.1762
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.2491
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.1245
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.4154
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3362
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.4815
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 1.1209
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9551
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0835
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 1.0661
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0883
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6692
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9851
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8831
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.7881
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9606
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1023
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8499
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9208
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5447
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3242
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5134
Platelet activation_Homo sapiens_hsa04611 SRC 0.4919
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3883
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5134
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3768
Measles_Homo sapiens_hsa05162 CSNK2A1 0.474
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4196
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4779
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5447
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5415
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5445
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3872
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5322
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5447
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5349
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4494
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4998
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4712
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4574
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4105
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4712
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4779
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4712
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5447
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4196
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.4703
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5447
Gap junction_Homo sapiens_hsa04540 SRC 0.5447
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4904
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4318
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4494
Axon guidance_Homo sapiens_hsa04360 MET 0.4861
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4998
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5445
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4105
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5445
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5926
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5445
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5875
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6156
Peroxisome_Homo sapiens_hsa04146 XDH 0.5481
Glioma_Homo sapiens_hsa05214 IGF1R 0.6156
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6165
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5981
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6156
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6156
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6156
Shigellosis_Homo sapiens_hsa05131 SRC 0.6156
Malaria_Homo sapiens_hsa05144 MET 0.6923
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.7729
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.7298
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8038
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8474
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8608
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8841
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8539
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8831
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9465


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)