TCM Prescription: Dan Le Tablets



Prescription Description
Prescription IDTCMF3962
Pinyin NameDan Le Pian
Chinese Name胆乐片
English NameDan Le Tablets
Function Description胁痛
IndicationsHypochondrium pain disorder, Cholecystitis
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
DC12 [Cholecystitis, 胆囊炎 ];
Human Tissues Associated with IndicationLiver, Gallbladder
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH1573 Bovis calculus 牛黄 TCMH1573
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.4718
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.4718
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, KIT, MAOA, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TERT, XDH 14.5549
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DNMT1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PPARA, PTGES, PTGS2, RELA, SRC, TERT, TOP1 12.7786
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CYP1B1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTGS2, RELA, SRC, XDH 10.959
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TERT, XDH 10.7301
[BP] GO:0023056 positive regulation of signaling AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TERT, XDH 10.7085
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1B1, FABP4, KDR, KIT, MMP9, PTGES, PTGS2, RELA, SRC, TERT 10.4575
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DNMT1, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGES, PTGS2, RELA, SRC 10.1387
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, AKR1C3, APP, AR, BCL2, CYP1B1, DNMT1, ESR1, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MMP12, MMP2, MMP9, PIM1, PTGES, PTGS1, PTGS2, RELA, SRC, TERT, XDH 10.0607
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1B1, DYRK1A, ESR1, F10, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TERT, XDH 9.8957
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1B1, DYRK1A, ESR1, F10, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TERT, XDH 9.72947
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DNMT1, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, RELA, SRC, TERT, TOP1, TOP2A 9.47569
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DNMT1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, KDR, KIT, MMP2, PIK3CA, PPARA, PTGES, PTGS2, RELA, SRC 9.45467
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CYP1B1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TERT, XDH 9.36259
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, F3, FLT3, GLO1, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, TERT, TOP2A, XDH 9.3529
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, F3, FLT3, GLO1, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, RELA, SRC, TERT, TOP2A, XDH 9.3529
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PTGS2, RELA, SRC, TOP1 9.06754
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CYP1B1, DYRK1A, ESR1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, XDH 9.04645
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, DNMT1, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, KIT, MMP2, PPARA, PTGS2, RELA, SRC 8.52039
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B3, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 8.41418
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PTGES, PTGS2, RELA, SRC 8.35606
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, F10, F3, FABP4, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SRC, TOP1 8.35531
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CNR1, CYP1A1, CYP1B1, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGES, PTGS2, RELA, SRC 8.32532
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F10, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, TERT, TOP2A, XDH 8.12929
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, APEX1, AR, BCL2, CA2, CA9, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, KIT, PPARA, PTGS2, RELA, SRC 8.12318
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, F3, FLT3, GLO1, HTR2B, IGF1R, KDR, MAP2K1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, RELA, SRC, TERT, TOP2A, XDH 7.99118
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CNR1, CYP1B1, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TERT, XDH 7.90757
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, BCL2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, RELA, TERT 7.72149
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, PIK3CA, PTGS2, RELA, SRC 7.59545
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, FABP3, FUT7, GLO1, HSD17B3, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, XDH 7.50873
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, RELA, SRC, TERT 7.39713
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F10, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, TERT, TOP2A, XDH 7.27698
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA3, ALOX15, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, CYP1B1, F10, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, SRC, TERT 7.17789
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.06435
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.96455
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 6.76553
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.69982
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, RELA, SRC 6.49802
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, DYRK1A, ESR1, F10, F3, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SRC, TERT, XDH 6.27958
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, RELA, SRC 6.27958
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.20974
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC 6.18928
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, AKR1C3, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B3, HTR1A, HTR2A, HTR2C 6.17966
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CYP1A1, CYP1B1, PTGES, PTGS1, PTGS2 6.12301
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PTGS2, RELA, SRC, TERT, TOP2A 5.98275
[BP] GO:0007187 None CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 5.92958
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B3 5.89027
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, DYRK1A, ESR1, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B3, HTR2A, HTR2B, HTR5A, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, TERT, TOP2A 5.86007
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B3 5.82996
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1B1, PTGES, PTGS1, PTGS2 5.76971
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SRC, TERT, TOP1, TOP2A, XDH 5.76971
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, FABP4, KIT, MMP9, PTGES, PTGS2, TERT 5.74385
[BP] GO:0060548 negative regulation of cell death AKR1B1, AR, AURKB, AXL, BCL2, GLO1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SRC, TERT 5.72922
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.72922
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1B1, PTGES, PTGS1, PTGS2 5.56597
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AR, AURKB, AXL, BCL2, GLO1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, RELA, SRC, TERT 5.56597
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F10, F3, KIT, MET, PIK3CA, PIK3CB, SRC 5.5115
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, RELA, SRC 5.45184
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, RELA, SRC 5.44197
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, FABP3, FABP4, GLO1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, RELA, SRC, TERT, TOP2A, XDH 5.44197
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F10, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 5.44197
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, SRC, TERT 5.41062
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 5.37659
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, AR, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, SRC, XDH 5.37228
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CNR1, CNR2, CYP1B1, DNMT1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, RELA, SRC 5.24598
[BP] GO:0019216 regulation of lipid metabolic process AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC 5.21242
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.14142
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, AKR1C3, APP, CA2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 5.14142
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HTR2A, MAP2K1, PTGS2, RELA, TERT 5.11554
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 5.08327
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, AR, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 5.08327
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, BACE1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 5.08327
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, BACE1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 5.08327
[BP] GO:0009966 regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CYP1B1, DYRK1A, ESR1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TERT, XDH 5.05864
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, BCL2, CA2, CACNA1C, CYP19A1, CYP1A1, ESR1, FLT3, HSD11B1, HSD17B3, KDR, KIT, MAP2K1, PIK3CA, PPARA, RELA, SRC 5.04775
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B3, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 5.0066
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1B1, FABP3, FABP4, FUT7, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 4.98207
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, APP, AR, AXL, CYP1B1, DNMT1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RELA, SRC 4.95731
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, KIT, MAP2K1, MET, PIK3CB, PIM1, SRC 4.95598
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1B1, HSD11B2, HTR1A, HTR2C, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, RELA, SRC, TERT, TOP2A 4.94747
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, AR, BCL2, DNMT1, DYRK1A, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.94494
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1B1 4.93365
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.93365
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CACNA1C, CNR1, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC 4.93365
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC 4.93365
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD11B1, HSD11B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SRC, TERT, TOP1, TOP2A, XDH 4.93365
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.90418
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.89544
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.89544
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.89544
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, AR, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.87567
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, AR, BCL2, DNMT1, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, XDH 4.87283
[BP] GO:0030334 regulation of cell migration ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.86956
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.86956
[BP] GO:0019371 None AKR1C3, PTGES, PTGS1, PTGS2 4.83986
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SRC, TERT, TOP1, TOP2A, XDH 4.82455
[BP] GO:0040012 regulation of locomotion ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, F3, HTR1D, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.80218
[BP] GO:0051270 regulation of cellular component movement ADORA3, APEX1, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.7874
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APEX1, APP, AR, DNMT1, ESR1, FLT3, HTR1B, IGF1R, KIT, MMP2, PTGS2, RELA, SRC 4.7874
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, FABP3, FABP4, GLO1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, RELA, SRC, TERT, TOP2A, XDH 4.78077
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD11B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, XDH 4.78077
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HSD17B3, HTR1A, MAOA 4.73613
[BP] GO:0031325 positive regulation of cellular metabolic process AKR1C3, ALOX15, APP, AR, AURKB, BCL2, DNMT1, DYRK1A, ESR1, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SRC, TERT, TOP2A, XDH 4.73613
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, AR, BCL2, DNMT1, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.67866
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, F3, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, PTGS2, RELA, SRC, TERT 4.66703
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, DYRK1A, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TOP1, XDH 4.65523
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B3, KIT, MAP2K1, SRC 4.63264
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.61441
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CYP1A1, CYP1B1, PTGES, PTGS1, PTGS2 4.57826
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, CACNA1C, HTR2A, HTR2B, HTR2C, KDR, SRC 4.57282
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC 4.57072
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B3 4.57024
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC 4.56598
[BP] GO:2000145 regulation of cell motility ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.56598
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, AR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, SRC, XDH 4.56598
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.56598
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, DYRK1A, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC, TOP1 4.55978
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MAP2K1, MMP12, MMP9, PIK3CB, PPARA, PTGS2, SRC, TERT 4.51622
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 4.51614
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.49437
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 4.49437
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1B1, PTGES, PTGS1, PTGS2 4.49437
[BP] GO:0003018 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.49437
[BP] GO:0048511 rhythmic process AXL, BCL2, DYRK1A, ESR1, HTR7, KIT, PPARA, SRC, TOP1, TOP2A 4.48496
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.48407
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.44686
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CNR1, CNR2, CYP19A1, DYRK1A, ESR1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP12, MMP2, PPARA, PTGS2, RELA, SRC, TERT, XDH 4.43098
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, RELA, SRC 4.41115
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B3 4.41115
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AR, AURKB, AXL, BCL2, GLO1, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, RELA, SRC, TERT 4.39283
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.36043
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, DYRK1A, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TOP1, XDH 4.3593
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1B1, FABP3, PPARA, PTGES, PTGS1, PTGS2 4.34608
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CNR1, CYP19A1, CYP1A1, ESR1, HSD11B2, HSD17B3, KIT, MAP2K1, MMP2, MMP9, PTGS2, SRC, TOP2A 4.32101
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1, HSD17B3 4.32101
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, AR, BCL2, DNMT1, DYRK1A, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, XDH 4.32101
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGES, PTGS1, PTGS2 4.30239
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, AR, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.26117
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.25408
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.2502
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, AR, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.22126
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, KIT, MMP2, PPARA, PTGS2, RELA, SRC, TERT 4.21273
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AR, AURKB, BCL2, DNMT1, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SRC, TERT, TOP2A, XDH 4.11299
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.10853
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1, HSD17B3 4.10853
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.10853
[BP] GO:0007193 None HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.10196
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2, TERT 4.10196
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, DYRK1A, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 4.07595
[BP] GO:0097746 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.06309
[BP] GO:0035296 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.06309
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, DNMT1, FABP3, KDR, MMP2, PTGES, PTGS2, RELA, SRC 4.06309
[BP] GO:0009893 positive regulation of metabolic process AKR1C3, ALOX15, APP, AR, AURKB, BCL2, DNMT1, DYRK1A, ESR1, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SRC, TERT, TOP2A, XDH 3.9158
[BP] GO:0050880 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.88765
[BP] GO:0035150 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.86784
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, RELA, SRC 3.84575
[BP] GO:0046777 protein autophosphorylation AURKB, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 3.81454
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, SRC 3.80459
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, KIT, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA 3.77919
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, RELA, SRC 3.77155
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AR, AURKB, BCL2, DNMT1, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SRC, TERT, TOP2A, XDH 3.76091
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 3.71614
[BP] GO:0003013 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 3.69062
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.69062
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, PTGES, PTGS2, RELA, SRC 3.69062
[BP] GO:0007154 None AKR1C3, AR, AXL, BCL2, CACNA1C, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 3.66012
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, HTR1B, KDR, PTGS2, RELA, SRC 3.63099
[BP] GO:0040016 embryonic cleavage PIK3CB, TOP1, TOP2A 3.6268
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.6268
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, SRC, TOP1, TOP2A 3.61346
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, F3, HTR2A, HTR2C, KDR, KIT, MAP2K1, PIM1, PTGS2, RELA, SRC, TERT 3.56735
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.47324
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, PTGES, PTGS2, RELA, SRC 3.47324
[BP] GO:0007188 None CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 3.45401
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SRC, TERT, TOP2A, XDH 3.45392
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.45392
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.45392
[BP] GO:0006693 None AKR1C3, PTGES, PTGS1, PTGS2 3.45392
[BP] GO:0006692 None AKR1C3, PTGES, PTGS1, PTGS2 3.45392
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.45392
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.45392
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.45392
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1B1, FABP3, GLO1, PPARA, PTGES, PTGS1, PTGS2 3.43142
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.4091
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, DNMT1, ESR1, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SRC 3.39756
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, HTR1B, IGF1R, MMP2, PTGS2, RELA, SRC 3.35521
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AR, AURKB, BCL2, ESR1, F3, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, RELA, SRC, TERT, XDH 3.35175
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SRC, TERT, TOP1, TOP2A, XDH 3.34305
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA 3.33361
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.33361
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DYRK1A, ESR1, FLT3, HSD11B1, HSD17B3, HTR5A, KDR, KIT, MAP2K1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SRC 3.32719
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.30168
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B3, KIT, MAP2K1, PTGS2, SRC 3.29504
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 3.29043
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGES, PTGS1, PTGS2 3.29043
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.24811
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.24811
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.24811
[BP] GO:0043269 regulation of ion transport ABCB1, APP, BCL2, CA2, CA7, CACNA1C, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 3.24383
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.23851
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.23219
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, GLO1, RELA 3.22177
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SRC, TERT, TOP1, TOP2A, XDH 3.21395
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, MAP3K7, PIM1, PPARA, RELA, SRC 3.19051
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CNR1, CYP1B1, ESR1, F3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, RELA, SRC, TERT, XDH 3.19051
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.17888
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.17815
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, TERT, TOP1, TOP2A, XDH 3.12034
[BP] GO:0009892 negative regulation of metabolic process AKR1C3, APEX1, APP, AR, AURKB, BCL2, CNR1, CNR2, DNMT1, DYRK1A, ESR1, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, RELA, SRC, TERT, XDH 3.1137
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, HTR1B, IGF1R, MMP2, PTGS2, RELA, SRC 3.09951
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DNMT1, HTR2A, HTR2B, HTR5A, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, RELA, SRC 3.09866
[BP] GO:0050790 regulation of catalytic activity ADORA3, APP, AR, AURKB, BCL2, CNR1, CNR2, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, XDH 3.09866
[BP] GO:0003008 None AKR1B1, AKR1C3, APP, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, KIT, PIK3CA, PTGS2, SRC 3.09571
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 3.09571
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA 3.09534
[BP] GO:0043405 regulation of MAP kinase activity FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CB, SRC 3.07806
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, RELA, SRC 3.07596
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CYP1A1, DYRK1A, ESR1, F10, F3, FLT3, FUT7, GLO1, HTR1A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SRC, TOP1, TOP2A, XDH 3.07022
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.06766
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.06766
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 3.06484
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.04253
[BP] GO:0006952 defense response ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, KIT, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA, SRC 3.04029
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, HSD17B3, PTGES, PTGS1, PTGS2 3.02983
[BP] GO:0007610 None APP, BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2 3.02649
[BP] GO:0043406 positive regulation of MAP kinase activity FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CB, SRC 3.0126
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B3 2.99641
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 2.9802
[BP] GO:1900274 regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 2.96874
[BP] GO:0010648 negative regulation of cell communication ACHE, AR, BCL2, CNR2, DYRK1A, ESR1, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, RELA, SRC, TERT, XDH 2.96646
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2, TERT 2.9651
[BP] GO:0023057 negative regulation of signaling ACHE, AR, BCL2, CNR2, DYRK1A, ESR1, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, RELA, SRC, TERT, XDH 2.95356
[BP] GO:0045597 positive regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CNR1, HTR2A, HTR2C, KDR, KIT, MAP2K1, PTGS2, RELA, TERT 2.94731
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA3, APP, AR, AURKB, BCL2, CNR1, CNR2, CYP1B1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, TERT, XDH 2.91919
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, SRC 2.91835
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, KDR, MAP2K1, MET, MMP12, PPARA, PTGS2, RELA 2.91835
[BP] GO:0007208 None HTR2A, HTR2C 2.91835
[BP] GO:0016488 None AKR1B10, AKR1C3 2.91835
[BP] GO:0016487 None AKR1B10, AKR1C3 2.91835
[BP] GO:0016107 None AKR1B10, AKR1C3 2.91835
[BP] GO:0006714 None AKR1B10, AKR1C3 2.91835
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 2.91313
[BP] GO:0080090 regulation of primary metabolic process ADORA3, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CNR1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, TERT, TOP2A, XDH 2.91136
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.90485
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 2.88548
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.88285
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.88285
[BP] GO:1901570 None ALOX15, ALOX5, PTGES, PTGS1, PTGS2 2.86667
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 2.86636
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B3, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SRC, TERT, TOP1, TOP2A, XDH 2.80089
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.78648
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 2.76606
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, AR, BCL2, CNR1, CNR2, CYP19A1, DYRK1A, ESR1, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, RELA, SRC, TERT, XDH 2.76001
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 2.76001
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTGS2, RELA, SRC, TERT 2.7593
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.75402
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.75402
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.73213
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, KIT, MAP3K7, PIM1, RELA 2.70503
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CNR1, CYP1B1, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, TERT, TOP2A, XDH 2.69281
[BP] GO:0050999 None CNR1, CNR2, HTR2B, TERT 2.67763
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, FABP4, MMP9, PTGS2 2.66523
[BP] GO:0008217 None AR, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 2.65013
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.62787
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.62787
[BP] GO:0070920 None ESR1, MAP2K1, TERT 2.62787
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.62787
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.62782
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SRC, TERT, TOP1, TOP2A, XDH 2.62554
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC 2.62044
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.593
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, RELA, SRC 2.57858
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APEX1, APP, AR, AURKB, BCL2, CNR1, DNMT1, DYRK1A, ESR1, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, RELA, SRC, TERT, XDH 2.55337
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.54514
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, IGF1R, MET, MMP9, PTGS2, RELA, SRC, XDH 2.51214
[BP] GO:0010518 positive regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.51208
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.50472
[BP] GO:0016095 None AKR1B10, AKR1C3 2.50472
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, APP, AR, BCL2, DNMT1, DYRK1A, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, XDH 2.49828
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.49139
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.43246
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.42053
[BP] GO:0046890 None AKR1C3, FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.40691
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, RELA, SRC, TERT 2.39821
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 2.37296
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.37264
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.34606
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.34606
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, FABP4, MMP9, PTGS2 2.34571
[BP] GO:0032768 None CNR1, CNR2, HTR2B, TERT 2.33959
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.33403
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.32327
[BP] GO:0032870 cellular response to hormone stimulus AKR1C3, APEX1, AR, ESR1, FLT3, KIT, RELA, SRC 2.32327
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, ESR1, KIT, PTGS2, SRC 2.32282
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.3212
[BP] GO:0046686 response to cadmium ion AKR1C3, KIT, MMP9, TERT 2.3212
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.3212
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TERT 2.31969
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, ESR1, FABP4, MAP3K7, MMP12, MMP2, PPARA, PTGS2, RELA, SRC 2.3183
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.31445
[BP] GO:0045859 regulation of protein kinase activity APP, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, SRC 2.31019
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.27022
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CB, SRC 2.26897
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.26897
[BP] GO:0030154 cell differentiation AKR1C3, ALPL, AR, AXL, BCL2, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, HTR2B, KDR, KIT, MAP2K1, MMP2, MMP9, PTGS2, TOP2A 2.2619
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9 2.25939
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MET, MMP12, PPARA, PTGS2, RELA, SRC, TERT, TOP2A 2.25262
[BP] GO:0038171 None CNR1, CNR2 2.25262
[BP] GO:0014827 None HTR1D, HTR2B 2.25262
[BP] GO:0010517 regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.25228
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, HTR1B, HTR2A, PTGS2 2.25228
[BP] GO:0009895 negative regulation of catabolic process BCL2, CNR1, HTR2B, MET, PIK3CA, PPARA, RELA 2.24865
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AR, AXL, BCL2, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, HTR2B, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PTGS2, SRC, TERT, TOP2A 2.24865
[BP] GO:1903530 regulation of secretion by cell ACHE, CACNA1C, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, SRC 2.24865
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, HTR1A, MAOA 2.24865
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.24476
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.23797
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.21863
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AURKB, BACE1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FUT7, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.19123
[BP] GO:0060193 positive regulation of lipase activity ESR1, HTR2A, HTR2B, KIT 2.18119
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, MAP2K1, MAP3K7, MMP9, PTGS2, RELA, SRC, TERT, TOP2A 2.17331
[BP] GO:0023052 None AR, CACNA1C, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.17181
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.1706
[BP] GO:0002682 regulation of immune system process ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, ESR1, KIT, MAP3K7, MMP12, MMP2, PIK3CA, PIK3CB, RELA, SRC 2.1706
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.1706
[BP] GO:0090066 None ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 2.15021
[BP] GO:0008285 negative regulation of cell proliferation ADORA3, APP, AR, BCL2, CYP1B1, FABP3, MAP2K1, PTGES, PTGS2, TERT, XDH 2.15002
[BP] GO:0060402 None CACNA1C, HTR2A, HTR2B, HTR2C 2.13598
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CNR1, CYP1A1, PTGS2, RELA 2.12757
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, PPARA, PTGS2, RELA, SRC 2.12245
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CYP1B1, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, TERT, TOP2A, XDH 2.12177
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, PTGES, PTGS2, RELA, SRC 2.12133
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.1161
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, ESR1, MET, SRC 2.08947
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.07855
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.07699
[BP] GO:0010641 None F3, SRC 2.07699
[BP] GO:0007598 None F10, F3 2.07699
[BP] GO:0071502 None HTR1B, HTR2B 2.07699
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.07699
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.07699
[BP] GO:0043549 regulation of kinase activity APP, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, SRC 2.06941
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, DYRK1A, ESR1, F10, F3, FLT3, FUT7, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, RELA, SRC, TOP1, TOP2A 2.06002
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, ESR1, F3, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, SRC, TERT, XDH 2.04222
[BP] GO:0050727 regulation of inflammatory response CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PTGS2, RELA 2.03018
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2 2.02942
[BP] GO:0051046 None ACHE, CACNA1C, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, SRC 2.01684
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.01465
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.00464
[BP] GO:0008209 androgen metabolic process CYP19A1, ESR1, HSD17B3 2.00464
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.00464
[BP] GO:0070371 None HTR2B, KDR, MAP2K1 2.00464
[BP] GO:0051246 regulation of protein metabolic process ALOX15, APP, AR, BCL2, DNMT1, DYRK1A, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, XDH 2.00316
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.00231
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA3, ALOX15, ALPL, APP, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, ESR1, F10, F3, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, SRC, TERT 7.57327
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, BACE1, CA4, CNR1, CNR2, F10, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 6.11528
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, SRC, TERT 6.07194
[CC] GO:0044459 plasma membrane part ABCB1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, F10, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PTGS2, SRC 5.85207
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, BACE1, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.65263
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MET, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, SRC 4.42687
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.45392
[CC] GO:0009330 None TOP1, TOP2A 2.91835
[CC] GO:0031233 None CA4, F10, F3 2.35863
[CC] GO:0031224 None ABCB1, ACHE, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA4, CA9, CACNA1C, CNR1, CNR2, ESR1, F10, F3, FLT3, FUT7, HSD11B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MET, PTGES 2.04863
[CC] GO:0045121 membrane raft APP, BACE1, CNR1, HTR2A, KDR, PTGS2, SRC 2.0099
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.4718
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.4718
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.4019
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.4019
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SRC, TERT, TOP1, TOP2A, XDH 14.2682
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.1605
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.0887
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.776
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.97991
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.45938
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 9.24968
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, F10, F3, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, SRC, TERT, TOP1, TOP2A, XDH 9.007
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DNMT1, ESR1, F10, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, TERT, TOP2A, XDH 8.79853
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, DNMT1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, XDH 8.65537
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CNR1, CYP19A1, CYP1A1, CYP1B1, DYRK1A, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP1, TOP2A 7.45902
[MF] GO:0038023 signaling receptor activity ADORA3, AR, AXL, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 6.61735
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.5431
[MF] GO:0004871 signal transducer activity ADORA3, AR, AXL, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PPARA 6.18012
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.07867
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD11B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, XDH 5.83944
[MF] GO:0004872 receptor activity ADORA3, AR, AXL, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 5.72922
[MF] GO:0060089 molecular transducer activity ADORA3, AR, AXL, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 5.48202
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 5.34148
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 5.34148
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.96347
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.93365
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA 4.63046
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.54505
[MF] GO:0004672 protein kinase activity AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC, TOP1 4.32293
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 4.15346
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.01347
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DNMT1, ESR1, F10, GLO1, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, TERT, TOP2A, XDH 3.81163
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2, HSD17B3, XDH 3.81163
[MF] GO:0016301 kinase activity AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 3.72391
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT, TOP1 3.54224
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B3 3.39516
[MF] GO:0097159 organic cyclic compound binding ABCB1, APEX1, APP, AR, AURKB, AXL, BCL2, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, FLT3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RELA, SHBG, SRC, TERT, TOP1, TOP2A, XDH 3.37445
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, DYRK1A, F10, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, RELA, SRC, TOP1, TOP2A, XDH 3.29434
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B3 3.29043
[MF] GO:1901363 heterocyclic compound binding ABCB1, APEX1, APP, AR, AURKB, AXL, BCL2, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, FLT3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RELA, SRC, TERT, TOP1, TOP2A, XDH 3.1628
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2, HSD17B3 3.10623
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.06766
[MF] GO:0004930 None ADORA3, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.06484
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1B1, PTGS1, PTGS2, SRC 2.9651
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.91835
[MF] GO:0045550 None AKR1B10, AKR1C3 2.91835
[MF] GO:0003845 None HSD11B1, HSD11B2 2.91835
[MF] GO:0071886 None HTR2A, HTR2C 2.91835
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1B1, PTGS1, PTGS2, SRC 2.81469
[MF] GO:0042562 hormone binding ACHE, AR, IGF1R, NQO2, SHBG 2.75402
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1B1, HSD11B2, NQO2, PTGES, PTGS1, PTGS2, SRC, XDH 2.73527
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, XDH 2.67763
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1B1, PTGS1, PTGS2 2.56715
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.50472
[MF] GO:0047718 None AKR1B10, AKR1C3 2.50472
[MF] GO:0004949 None CNR1, CNR2 2.50472
[MF] GO:0047045 None AKR1C3, HSD17B3 2.50472
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1B1, XDH 2.50416
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.35863
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, DNMT1, DYRK1A, FLT3, HSD11B2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TOP2A, XDH 2.33222
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, DNMT1, DYRK1A, FLT3, HSD11B2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TOP2A, XDH 2.33043
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TOP2A 2.32251
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, DYRK1A, ESR1, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP9, NQO2, PTGS2, RELA, TERT, TOP2A, XDH 2.3212
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, F10, F3, FABP3, FABP4, HSD11B2, PPARA, SHBG 2.26873
[MF] GO:0005497 None AR, SHBG 2.25262
[MF] GO:0036094 small molecule binding ABCB1, AURKB, AXL, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HSD11B2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TOP2A, XDH 2.25228
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TOP2A 2.22947
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1B1 2.21863
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TOP2A 2.19778
[MF] GO:0008134 transcription factor binding APEX1, AR, BCL2, ESR1, FLT3, PIM1, PPARA, RELA, SRC, TERT 2.12245
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity KIT, MET, PIK3CA, PIK3CB 2.09134
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.08105
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1B1 2.08023
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.08023
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.08023
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.04222
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity KIT, MET, PIK3CA, PIK3CB 2.03486


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, HTR1E, MAOA, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, CACNA1C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 23.4074
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 9.6482
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, MAP2K1, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C, PIK3CB, PPARA, HTR4, RELA 9.0711
Pathways in cancer_Homo sapiens_hsa05200 MAP2K1, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, RELA, IGF1R, AR, PIK3CA, KIT, BCL2, MET 7.7975
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.7224
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 7.5342
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, KIT, PIM1, PIK3CB, RELA 7.1915
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.8462
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, CYP1A1, HSD17B3, AKR1C3, CYP1B1, CYP19A1 7.1915
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 5.9706
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3, RELA 5.7296
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 5.7296
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, PIK3CA, SRC, CNR1, KIT, KDR, PIK3CB, MET, IGF1R 5.7296
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.7296
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, PIK3CA, KIT, KDR, PIK3CB, MET, RELA, IGF1R 5.5929
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, DNMT1, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 5.5929
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, AKR1C3, PTGS2, PTGES, PTGS1 5.7226
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.5929
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, CACNA1C, HTR2A, HTR5A, HTR4 5.3433
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, KIT, PIK3CB, MET 5.5929
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, RELA 5.4561
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.9918
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, PIK3CA, SRC, BCL2, PIK3CB, MMP9, RELA 4.8827
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.7597
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, MAOA, ALOX15, HSD17B3, AKR1C3, AKR1B1, PTGS2, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, CYP1A1, ALPL, XDH, PTGES 4.4878
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, PIK3CA, BCL2, CACNA1C, PIK3CB 4.494
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, RELA, IGF1R 4.3565
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 4.667
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, MAP3K7, RELA 4.3705
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 4.7286
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.3433
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, PIK3CA, ADORA3, BCL2, PIK3CB, RELA 4.3565
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2 3.7409
Melanoma_Homo sapiens_hsa05218 MAP2K1, PIK3CA, PIK3CB, MET, IGF1R 4.3197
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C 4.0003
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2, RELA 3.9378
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.5478
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.5759
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, HTR2B, HTR2C, HTR2A 3.9017
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1 3.3432
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.3243
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.1789
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.0953
Glioma_Homo sapiens_hsa05214 MAP2K1, PIK3CA, PIK3CB, IGF1R 3.2837
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, PIK3CA, BCL2, PIK3CB 3.3432
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, PIK3CA, PIK3CB, RELA 3.2776
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PIK3CA, PIK3CB, RELA 3.1447
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, CACNA1C, PIK3CB 2.8105
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, PIK3CA, PIK3CB, RELA 3.1447
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.2776
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.828
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, PIK3CA, SRC, PIK3CB 2.8941
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.6807
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PIK3CA, SRC, PIK3CB, RELA 2.6131
Epstein-Barr virus infection_Homo sapiens_hsa05169 PIK3CA, BCL2, PIK3CB, MAP3K7, RELA 2.4969
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.7513
Adherens junction_Homo sapiens_hsa04520 SRC, MAP3K7, MET, IGF1R 3.1306
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, RELA, IGF1R 2.8105
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.212
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.0595
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2, PTGS2, MAP3K7, RELA 2.8105
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA, RELA 2.6054
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A1, CYP1B1, PTGS2 2.9842
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.4499
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.4969
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.3368
Measles_Homo sapiens_hsa05162 PIK3CA, PIK3CB, MAP3K7, RELA 2.3118
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, MAP3K7, IGF1R 2.4363
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, RELA 2.3368
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.2536
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, PIK3CA, KIT, PIK3CB 2.2457
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.1248
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, CACNA1C, PIK3CB 2.2082
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA, RELA 2.1928
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.1276
Influenza A_Homo sapiens_hsa05164 MAP2K1, PIK3CA, PIK3CB, RELA 1.9855
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2983
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.308
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB, RELA 1.7875
Tight junction_Homo sapiens_hsa04530 SRC 0.3649
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, PIK3CA, SRC, PIK3CB 1.7305
Wnt signaling pathway_Homo sapiens_hsa04310 MAP3K7 0.3605
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA 1.5024
Axon guidance_Homo sapiens_hsa04360 MET 0.3923
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, TERT, PIK3CB, RELA 1.49
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.4604
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4264
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1, PIK3CA, PIK3CB 1.5444
Insulin signaling pathway_Homo sapiens_hsa04910 MAP2K1, PIK3CA, PIK3CB 1.5153
Herpes simplex infection_Homo sapiens_hsa05168 MAP3K7, RELA 0.6942
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.7062
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.639
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, PIK3CA, PIK3CB 1.8486
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1, PIK3CA, PIK3CB 1.9234
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4662
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, RELA 1.8511
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4828
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4817
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB, RELA 1.8184
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4828
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP, CACNA1C 1.3501
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C, PTGS2 1.8486
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4972
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.8996
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.305
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4972
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.9465
Salmonella infection_Homo sapiens_hsa05132 RELA 0.5084
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.51
Peroxisome_Homo sapiens_hsa04146 XDH 0.5161
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PIK3CB 2.2536
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5197
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5161
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5309
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, KIT 1.077
Pertussis_Homo sapiens_hsa05133 RELA 0.5427
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 2.1928
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.545
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0889
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.545
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.3118
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.2536
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A1, CYP1B1 2.1928
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA 0.5658
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, PIK3CA, PIK3CB 2.517
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.165
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.165
Renin secretion_Homo sapiens_hsa04924 CACNA1C 0.5859
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, PIK3CA, PIK3CB 2.449
Retinol metabolism_Homo sapiens_hsa00830 CYP1A1 0.5857
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5859
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RELA 0.5857
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.2423
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.3235
Legionellosis_Homo sapiens_hsa05134 RELA 0.6386
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.3554
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3197
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.3197
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.6054
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.3235
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.3501
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.813
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.3637
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6653
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4245
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.4245
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6702
Malaria_Homo sapiens_hsa05144 MET 0.6751
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6887
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.4541
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.43
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6942
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7027
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6968
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A1, CYP1B1 2.8105
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.5485
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7347
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7823
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7347
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6146
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8462
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8222
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA 0.7823
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.869
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7997
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15 0.8462
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9087
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8778
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8589
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.869
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7875
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.9041
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1215
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.0413
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1127
Caffeine metabolism_Homo sapiens_hsa00232 XDH 1.4835


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)