TCM Prescription: Chan Long Ding Chuan Recipe



Prescription Description
Prescription IDTCMF3957
Pinyin NameChan Long Ding Chuan He Ji
Chinese Name蟾龙定喘合剂
English NameChan Long Ding Chuan Recipe
Function Description咳嗽, 哮病, 喘病
IndicationsWheezing disorder, Dyspnea
Disease ICD-11 Category SA81 [Wheezing disorder (TM1), 哮病 (TM1) ];
MD11.5 [Dyspnoea, 呼吸困难 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH232 Bufo melanostictus 蟾蜍 TCMH232 GBAP778-09
TCMH456 Rhizoma dioscoreae nipponicae 地龙 TCMH456
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH877 Radix ginseng rubra 红参 TCMH877 GBVE1679-11
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1677 Pinellia ternata 清半夏 TCMH1677 GBVT1123-13, GBVY1693-14
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH2695 NA 猪胆 TCMH2695
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH2722 Perilla frutescens var. arguta 紫苏叶 TCMH2722 ITSAF2620-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2257
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2257
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F10, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, MET, MIF, PPARA, PPARG, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 13.9028
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.0385
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HSP90AB1, HTR1B, HTR5A, IDO1, IGF1R, MMP2, MMP9, NR3C1, PPARA, PPARG, PTGS2, SRC, TRPV1, TYR 12.394
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GBA2, HTR2B, HTR2C, IDO1, MIF, PIM1, PPARA, PPARG, PTGS2, TYR, XDH 12.2094
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.1983
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, NR3C1, PPARG, PTGS2, SRC, TYR 12.0694
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, PPARG, PTGS2, SRC, TRPV1, TYR 11.9664
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PPARA, PPARG, PTGS2, TRPV1 11.4435
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HTR1B, HTR5A, IDO1, IGF1R, KDR, MMP2, NR3C1, PPARA, PPARG, PTGS2, SRC, TRPV1, TYR 11.139
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HSP90AB1, HTR1B, HTR2A, HTR2B, HTR2C, KDR, NR3C1, PPARG, PTGS2, SRC, TRPV1 10.0415
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FLT3, HCAR2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 9.747
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, F2, HCAR2, HTR2A, HTR2B, HTR2C, KDR, MIF, PTGS2, SRC, TNKS, TNKS2, TRPV1 9.69498
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, HSP90AB1, HTR1B, HTR5A, NR3C1, PPARG, PTGS2, SRC, TRPV1, TYR 9.28459
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.092
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F2, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IDO1, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARG, PTGS2, SRC, XDH 9.03915
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F2, F3, FLT3, HCAR2, HSP90AB1, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 8.96775
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F2, F3, FLT3, HCAR2, HSP90AB1, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 8.93108
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 8.74678
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.5774
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.47005
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, NR3C1, PPARA, PPARG, PTGS2, SRC, TRPV1 8.33156
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 8.20702
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS2 8.08628
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F2, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS2, TRPV1, TYR 8.07587
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F10, F2, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, PPARA, PPARG, PTGS2, PTPN1, SRC, TRPV1, TYR 8.03825
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS2 7.80985
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F2, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2 7.80985
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PPARG, PTGS2, TYR, XDH 7.71482
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HSP90AB1, HTR2B, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARG, PTGS2, PTPN1, SRC, TRPV1, XDH 7.67778
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HSP90AB1, HTR2B, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TRPV1, XDH 7.66209
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F10, F2, F3, FABP4, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, HTR6, IDO1, KDR, MET, MIF, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.43928
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C 7.43928
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 7.41028
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, F10, F2, F3, HCAR2, HSP90AB1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, SRC, TRPV1 7.2134
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F2, F3, FLT3, HCAR2, HSP90AB1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.20506
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PPARG, PTGS2, SRC 7.15992
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HSP90AB1, HTR2B, IDO1, IGF1R, KDR, MIF, MMP9, PIM1, PPARG, PTGS2, PTPN1, SRC, TRPV1, XDH 7.09229
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F2, F3, FLT3, HCAR2, HSP90AB1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.05941
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, F10, F2, F3, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.04791
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, NR3C1, PPARA, PPARG, PTGS2, SRC, TRPV1 7.03353
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.91671
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, TRPV1 6.78335
[BP] GO:0007187 None ADORA1, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 6.7266
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.70016
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PPARG, PTGS2 6.67744
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, F2, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, PPARG, PTGS2, SRC 6.63613
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, MIF, SRC, TNKS, TNKS2, TRPV1 6.58795
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F10, F2, F3, FABP4, FLT3, HSP90AA1, HSP90AB1, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.55649
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, MET, MIF, PPARA, PPARG, PTGS2 6.4731
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, F10, F2, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MIF, PTGS2, PTPN1, SRC, XDH 6.38558
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP2, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 6.38558
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS2 6.30699
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MIF, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SRC, TNKS, TNKS2, TRPV1 6.27141
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, F2, HTR2A, HTR2B, HTR2C, KDR, SRC, TRPV1 6.23122
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.12525
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CNR1, CNR2, CYP1A1, CYP1B1, HSP90AA1, HTR1B, HTR1D, KDR, SRC 6.12379
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, MIF, PPARA, PPARG, PTGS2 6.08988
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B 5.87316
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, HTR2B, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 5.84417
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, HTR2B, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTGS2, PTPN1, SRC 5.72101
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.63051
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.4919
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HSP90AB1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 5.4919
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 5.46103
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CDK6, CNR1, CNR2, CYP19A1, ESR1, F2, F3, FABP4, HSP90AA1, HSP90AB1, IDO1, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PPARG, PTGS2, PTPN1, SRC, XDH 5.42315
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, TRPV1 5.40146
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, F2, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, MET, PPARG, SRC, TRPV1 5.34046
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.21761
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.19811
[BP] GO:0003018 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 5.19066
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.13859
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, HTR2B, IDO1, IGF1R, KDR, MIF, MMP9, PIM1, PTGS2, PTPN1, SRC 5.11522
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HCAR2, HSP90AB1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 5.04912
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.04566
[BP] GO:0007193 None ADORA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.03118
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 5.02569
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, HSP90AB1, HTR1B, KDR, NR3C1, PTGS2, SRC, TRPV1 4.99395
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, F2, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 4.93881
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CNR1, CNR2, CYP19A1, ESR1, F2, F3, FABP4, IDO1, KDR, MET, MIF, MMP12, PPARA, PPARG, PTGS2 4.93218
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, HTR1D, IGF1R, KDR, MET, MIF, MMP9, PPARG, PTGS2, SRC 4.88749
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HSP90AB1, HTR1B, IGF1R, KDR, MMP2, NR3C1, PPARG, PTGS2, SRC, TRPV1 4.88749
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS 4.84816
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HSP90AA1, HSP90AB1, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PPARG, PTGS2, SRC, TRPV1, TYR 4.84816
[BP] GO:0097746 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.83564
[BP] GO:0035296 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.83564
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, PPARG, SRC 4.81129
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, F2, HCAR2, HSP90AB1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, SRC, TRPV1 4.79887
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSP90AB1, HTR1B, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARG, PTGS2, SRC, TRPV1 4.74665
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, SRC 4.6957
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 4.68893
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MIF, MMP9, PPARG, PTGS2, SRC 4.68315
[BP] GO:0050880 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.65375
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 4.64995
[BP] GO:0035150 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.63455
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PTGS2 4.59377
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CNR1, CNR2, ESR1, F2, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARG, SRC 4.53249
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F2, F3, HCAR2, HTR2A, HTR2B, IDO1, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARG, PTGS2, SRC, TRPV1 4.52721
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSP90AB1, KDR, PPARA, PPARG, SRC, TYR 4.45383
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, MIF, PIM1, PPARA, PPARG, PTGS2, TYR 4.45025
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HSP90AB1, HTR1B, IGF1R, MMP2, PPARA, PPARG, PTGS2, SRC, TRPV1, TYR 4.43293
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HSP90AB1, HTR2A, HTR2B, HTR5A, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, PPARG, PTGS2, SRC, TNKS2, TYR 4.42049
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MIF, MMP9, PPARG, PTGS2, SRC 4.35044
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GBA2, HTR1A, TYR 4.32651
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 4.31979
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.31044
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, ESRRB, F2, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 4.31044
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, F2, FABP3, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 4.31044
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, F2, FABP3, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 4.31044
[BP] GO:0003013 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.31044
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F2, F3, HCAR2, HSP90AB1, HTR2A, HTR2B, HTR2C, IDO1, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARG, PTGS2, SRC, TNKS2, TRPV1, XDH 4.30775
[BP] GO:0009266 None ADORA1, HSP90AA1, HTR1B, HTR2A, HTR2B, PPARG, PTGS2, TRPV1 4.29001
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, F2, FABP4, HSP90AB1, IDO1, MMP12, MMP2, PPARA, PPARG, PTGS2, PTPN1, SRC 4.26647
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MIF, MMP9, PPARG, PTGS2, SRC 4.25505
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 4.25505
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC, TNKS, TNKS2 4.25505
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 4.23564
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, F2, FABP3, FABP4, FLT3, HSP90AB1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 4.23564
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS, TNKS2 4.22163
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESR2, F2, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, SRC, XDH 4.20731
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, SRC 4.20731
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, PTGS2, SRC, TRPV1 4.20277
[BP] GO:0007188 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.19105
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, F2, FABP3, FABP4, FLT3, HSP90AB1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 4.18738
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, F2, FABP4, HCAR2, HSP90AB1, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 4.12666
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, SRC 4.1157
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, MIF, PTGS2 4.1073
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.09341
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.09341
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 4.07719
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HSP90AB1, HTR1B, IGF1R, MMP2, PPARA, PPARG, PTGS2, SRC, TRPV1, TYR 4.07344
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, F2, HCAR2, HSP90AA1, HSP90AB1, IDO1, MIF, MMP12, MMP2, PPARG, PTPN1, SRC 4.03241
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.02984
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, F2, HCAR2, PTGS2, TNKS, TNKS2 4.02212
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.00233
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, SRC 4.00233
[BP] GO:0071502 None HTR1B, HTR2B, TRPV1 4.00016
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.00016
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, BCL2, CA12, CA2, CA7, CNR1, ESR1, F2, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PPARG, TRPV1 3.98356
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, PPARG, PTGS2, SRC, TNKS, TNKS2, TRPV1 3.97866
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, F2, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.97682
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, F2, HSP90AA1, HSP90AB1, PTGS2, TRPV1, XDH 3.97682
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, MIF, PIM1, PPARA, PPARG, PTGS2, TYR 3.9673
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 3.96116
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSP90AA1, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.88298
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, MIF, PIM1, PPARA, PPARG, PTGS2, TYR 3.8682
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, F2, FABP4, IDO1, PPARA, PPARG, PTGS2 3.83887
[BP] GO:0007154 None ADORA1, AXL, BCL2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PPARG, PTGS2, TRPV1 3.79118
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.76029
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.72915
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.72915
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, IDO1, MIF, MMP12, PPARG 3.65866
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F10, F2, F3, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.62436
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7, TRPV1 3.59407
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, ESRRB, F2, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.59407
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.50423
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.50423
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.50423
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process F2, HSP90AA1, HSP90AB1, PTGS2, TRPV1, XDH 3.48199
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 3.45907
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.44645
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PPARG, PTGS2, SRC, TRPV1, TYR 3.42301
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS 3.42301
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.41983
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 3.36401
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 3.35898
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, F2, F3, FABP4, IDO1, KDR, MET, MIF, PTGS2 3.34259
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, SRC, TRPV1 3.32182
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, F2, HCAR2, HSP90AB1, HTR2B, MIF, MMP12, PPARG, PTGS2, SRC, TRPV1 3.25861
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F2, F3, FABP4, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, MIF, MMP9, PPARG, PTGS2, PTPN1, SRC, TNKS, XDH 3.2515
[BP] GO:0090066 None ADORA1, ALOX15, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.22206
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARG, PTGS2, SRC 3.20629
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, HTR1B, HTR2A, PTGS2 3.18602
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FLT3, GBA2, HSD11B1, HSD17B2, HSP90AB1, HTR5A, KDR, MMP9, PIM1, PPARA, PPARG, PTGS2, SRC, TYR 3.16422
[BP] GO:0046320 None CNR1, FABP3, PPARA, PPARG 3.16422
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 3.15616
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, F2, F3, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PPARG, PTGS2, PTPN1, SRC, XDH 3.14481
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, HSP90AB1, IDO1, MMP2, MMP9, PPARG, PTGS2, SRC 3.14108
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG 3.13925
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.13205
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.13205
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA3, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, F2, HSD11B2, HSP90AA1, HSP90AB1, HTR1A, HTR2C, IDO1, MIF, MMP2, MMP9, PPARA, PPARG, PTGS2, PTPN1, SRC, TRPV1 3.12422
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, MIF, PTGS2 3.12154
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 3.11783
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 3.11783
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, MET, MMP12, NR3C1, PPARA, PPARG, PTGS2, SRC, TNKS, TNKS2, TRPV1 3.07688
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, F2, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.05873
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSP90AB1, HTR1B, IGF1R, KDR, MIF, MMP2, MMP9, NR3C1, PPARG, PTGS2, PTPN1, SRC, TRPV1 3.05672
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.04927
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.04498
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, MIF, PPARG, PTPN1, SRC, TNKS 3.02409
[BP] GO:0031324 negative regulation of cellular metabolic process AURKB, BCL2, CNR1, CSNK2A1, ESR1, ESR2, ESRRA, F2, FABP4, HSP90AB1, HTR1B, HTR1E, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 3.02409
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, SRC 3.02014
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, F2, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, MIF, PTPN1, SRC, TNKS 3.00162
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESR1, F2, F3, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PPARG, PTGS2, PTPN1, SRC, XDH 2.98892
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, F2, MMP12, PPARA, PPARG 2.98768
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, F2, HSD11B2, HTR2A, IDO1, MMP12, PPARG, PTGS2, SRC, TRPV1, TYR 2.98475
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, HSP90AB1 2.97254
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, FLT3, HSP90AA1, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 2.95522
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, F2, PPARA, PPARG 2.95417
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, F2, F3, FABP4, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, MET, MIF, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TRPV1, XDH 2.94847
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HSD11B2, PPARG, PTGS2, SRC, TRPV1, TYR 2.93832
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PPARG, PTGS2, PTPN1, SRC, XDH 2.93832
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PPARG, PTGS2, PTPN1, SRC, XDH 2.92173
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSP90AB1, PPARG, PTGS2, SRC 2.90186
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, HTR2A, MET, TRPV1 2.90168
[BP] GO:0090087 None ACHE, ADORA1, CA2, CNR1, F2, HCAR2, HSP90AB1, HTR2B, HTR2C, MIF, MMP12, PTGS2, PTPN1, SRC 2.90168
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, F2, PPARA 2.88026
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, HTR2A, HTR2B, HTR2C, PPARA, PPARG, TRPV1 2.86374
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, HCAR2, IDO1, MMP9, PPARG, PTGS2, SRC, TRPV1, XDH 2.85453
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HSP90AA1, HTR2B, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.85223
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CNR1, F2, HTR1A, HTR1B, HTR2A, MIF, MMP9, PTGS2 2.85223
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, FLT3, HTR2A, HTR2B, HTR2C, KDR, MIF, PTPN1, SRC, XDH 2.84294
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.82911
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, HCAR2, IDO1, MMP9, PPARG, PTGS2, SRC, TRPV1, XDH 2.82185
[BP] GO:0007208 None HTR2A, HTR2C 2.81923
[BP] GO:0009115 None AOX1, XDH 2.81923
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.81923
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.81923
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.81923
[BP] GO:0051973 positive regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, TNKS 2.8164
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 2.80372
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.78407
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.78219
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 2.76347
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.75545
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, ESR1, ESR2, F2, F3, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, MET, MIF, MMP9, PPARG, PTPN1, SRC, TNKS, XDH 2.7549
[BP] GO:0051098 regulation of binding AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, PPARG, SRC, TNKS 2.75306
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, F2, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.74965
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.74965
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PPARG, PTGS2 2.74965
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HCAR2, HSP90AB1, HTR2B, MET, PPARA 2.74965
[BP] GO:0050793 regulation of developmental process ALOX12, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F2, F3, HSP90AB1, HTR2A, HTR2C, IDO1, KDR, MIF, PIM1, PPARA, PPARG, PTGS2, SRC, TNKS2, TRPV1, XDH 2.74469
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, PPARG, PTGS2, TRPV1, TYR 2.7182
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.70714
[BP] GO:1901652 response to peptide AKR1B1, FABP3, HSD11B2, IGF1R, PPARA, PPARG, PTGS2, SRC, TRPV1 2.70557
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, FLT3, HSP90AA1, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 2.70343
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, IDO1, MIF, PTGS2 2.7028
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, ESR1, F10, F2, F3, FLT3, FUT7, GBA2, HSP90AA1, HTR1A, HTR2B, HTR2C, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.68668
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.68524
[BP] GO:0030335 positive regulation of cell migration ALOX12, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.68387
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSP90AB1, PPARG, SRC 2.68387
[BP] GO:0007610 None BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IDO1, PPARA, PTGS2, TRPV1 2.67669
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, HTR2A, HTR2B, HTR2C, KDR, MIF, SRC 2.67669
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, MIF, PTGS2 2.67581
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.67047
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.67047
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PPARG, PTGS2, SRC, TRPV1 2.66105
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, HTR2A, HTR2B, HTR2C, KDR, MIF, PTPN1, SRC 2.64809
[BP] GO:1904407 positive regulation of nitric oxide metabolic process HSP90AA1, HSP90AB1, PTGS2, TRPV1 2.63616
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process HSP90AA1, HSP90AB1, PTGS2, TRPV1 2.63616
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, MIF 2.63616
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PPARG, PTGS2, TYR 2.63616
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, MIF, PIM1, SRC, TYR 2.61339
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CNR2, CYP19A1, F2, MIF, PPARA, PPARG 2.60315
[BP] GO:0019217 None CNR1, FABP3, PPARA, PPARG, PTGS2 2.59249
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.59249
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.59249
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2 2.592
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG 2.592
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, SRC 2.592
[BP] GO:2000147 positive regulation of cell motility ALOX12, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.58377
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, HCAR2, IDO1, MMP9, PPARG, PTGS2, SRC, TRPV1, XDH 2.58246
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PPARG, PTGS2, SRC, XDH 2.58246
[BP] GO:0051094 positive regulation of developmental process ALOX12, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HSP90AB1, HTR2A, HTR2C, IDO1, KDR, PIM1, PPARG, PTGS2, SRC 2.56426
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, HTR7, PPARA, PPARG, SRC 2.56426
[BP] GO:0050999 None CNR1, CNR2, HSP90AA1, HTR2B 2.53758
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.52055
[BP] GO:0051209 None HTR2A, HTR2B, HTR2C, TRPV1 2.50317
[BP] GO:0051283 None HTR2A, HTR2B, HTR2C, TRPV1 2.50317
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, HSP90AA1, HSP90AB1, IGF1R, SRC, TNKS, TNKS2 2.50317
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.49828
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.49705
[BP] GO:0009410 None CNR1, CNR2, HSP90AB1, HTR1B, NR3C1, PPARG 2.49434
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.49434
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.49434
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, ESR1, F2, F3, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, MIF, PPARG, PTPN1, SRC, TNKS, XDH 2.47573
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX12, ALOX15, CYP1A1, IDO1, MIF, PTGS2 2.46816
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.46816
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, HTR2B, MIF, MMP12, SRC, TRPV1 2.46816
[BP] GO:0043279 None CNR1, HSP90AB1, HTR1B, PPARG, TRPV1 2.46184
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.45751
[BP] GO:0008217 None ADORA1, CNR1, HSD11B2, PPARA, PPARG, PTGS2 2.45735
[BP] GO:2000107 negative regulation of leukocyte apoptotic process AURKB, AXL, IDO1, MIF 2.44866
[BP] GO:0046110 None AOX1, XDH 2.44866
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44866
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, F2, IDO1, MMP12, PTGS2, SRC 2.41265
[BP] GO:0040017 positive regulation of locomotion ALOX12, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.39775
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.39406
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.37628
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 2.33143
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.32551
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.32551
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.3245
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, MIF, PTGS2 2.3188
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process HSP90AA1, HSP90AB1, PTGS2, TRPV1 2.29445
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.29445
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, PTPN1, SRC, XDH 2.29305
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, F2, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, SRC 2.28298
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.28298
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.28298
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PPARG, PTGS2, SRC, XDH 2.27093
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.27093
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.27093
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.27093
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1 2.26286
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, F2, IDO1, MMP12, PTGS2, SRC 2.25263
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PPARG, PTGS2, SRC 2.24613
[BP] GO:0033555 multicellular organismal response to stress BCL2, HTR1A, HTR2C, IDO1 2.24572
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, F2, HCAR2, HSP90AB1, HTR2B, MIF, MMP12, PTGS2, SRC 2.23195
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.21925
[BP] GO:0032768 None CNR1, CNR2, HSP90AA1, HTR2B 2.21772
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.21564
[BP] GO:0007267 None ADORA1, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.20086
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.19702
[BP] GO:0050866 negative regulation of cell activation ALOX12, AXL, CNR1, CNR2, F2, IDO1 2.19702
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.19702
[BP] GO:0070213 None TNKS, TNKS2 2.19702
[BP] GO:0006145 None AOX1, XDH 2.19702
[BP] GO:0038171 None CNR1, CNR2 2.19702
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.19702
[BP] GO:0014827 None HTR1D, HTR2B 2.19702
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.18843
[BP] GO:0097553 None HTR2A, HTR2B, HTR2C, TRPV1 2.17775
[BP] GO:0045428 regulation of nitric oxide biosynthetic process HSP90AA1, HSP90AB1, PTGS2, TRPV1 2.17775
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.17775
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.17775
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.17775
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.17775
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.17775
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.17775
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, IDO1 2.17326
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, HTR2A, MIF, PTPN1, SRC 2.16954
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TRPV1, TYR 2.16121
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, F10, F2, FABP3, HSP90AA1, HSP90AB1, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, MMP9, PPARA, PPARG, SRC, TNKS, TNKS2, TRPV1, XDH 2.16121
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.15893
[BP] GO:0045600 positive regulation of fat cell differentiation HTR2A, HTR2C, PPARG, PTGS2 2.1322
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.1322
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.12785
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, MIF, PTPN1, SRC 2.12383
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, F2, MIF, PTGS2, TRPV1 2.1225
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F10, F2, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC, TNKS 2.12067
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, HSP90AA1, HSP90AB1, HTR1A, PTGS2, TRPV1 2.11417
[BP] GO:0002793 None ACHE, ADORA1, HCAR2, HTR2B, MIF, MMP12, SRC 2.11417
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, NR3C1, PPARG, SRC 2.11417
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.11178
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CA3, CYP1B1, MMP9, PTGS2, SRC 2.10476
[BP] GO:0051282 None F2, HTR2A, HTR2B, HTR2C, TRPV1 2.10356
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.0866
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.08516
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.08516
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.08516
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSP90AA1, IDO1, XDH 2.08145
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, F10, F2, FABP3, HSP90AA1, HSP90AB1, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, MMP9, PPARA, PPARG, SRC, TNKS, TRPV1, XDH 2.08145
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, F2, FLT3, HSP90AB1, HTR2A, HTR2B, MIF, PTPN1, SRC 2.06624
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, FLT3, HSP90AB1, HTR2A, HTR2B, MIF, PTPN1, SRC 2.04632
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, HCAR2, HTR1A, HTR2A, HTR2C 2.04488
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HSP90AA1, HTR2B, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.04311
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, F2, FUT7, HTR2B, HTR6, KDR, MET, MIF, MMP1, MMP12, MMP9, SRC 2.03905
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, ESR1, F2, HSP90AA1, HSP90AB1, IDO1, MIF, MMP12, MMP2, PPARG, PTPN1, SRC 2.03905
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, MIF, PTPN1, SRC 2.03865
[BP] GO:0030336 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, MIF, PPARG 2.03112
[BP] GO:0002791 None ACHE, ADORA1, CNR1, HCAR2, HTR2B, HTR2C, MIF, MMP12, SRC 2.03112
[BP] GO:0046394 None ALOX12, ALOX15, ALOX5, CYP1A1, IDO1, MIF, PTGS2 2.03112
[BP] GO:0060402 None HTR2A, HTR2B, HTR2C, TRPV1 2.03112
[BP] GO:0043696 None CDK6, ESRRB 2.03112
[BP] GO:0043697 None CDK6, ESRRB 2.03112
[BP] GO:0010641 None F3, SRC 2.03112
[BP] GO:0007598 None F10, F3 2.03112
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.03112
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.03112
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.03112
[BP] GO:0010891 None PPARA, PPARG 2.03112
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 2.02589
[BP] GO:0016053 None ALOX12, ALOX15, ALOX5, CYP1A1, IDO1, MIF, PTGS2 2.02375
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, ESR1, F2, FABP3, HTR2A, HTR2B, HTR2C, TRPV1 2.01995
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.0103
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.00783
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.00783
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.00725
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, F2, F3, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MIF, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, TRPV1 2.007
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, F10, F2, FABP3, HSP90AA1, HSP90AB1, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, MMP9, PPARA, PPARG, SRC, TNKS, TRPV1, XDH 2.00051
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CNR1, CNR2, F10, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, TRPV1 5.40146
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, F10, F2, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR 4.90625
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CNR1, CNR2, F10, F2, F3, FLT3, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTGS2, SRC, TRPV1 4.89529
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, ESR1, F10, F2, F3, FLT3, GBA2, HCAR2, HSP90AA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC, TRPV1 4.50031
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, F10, F2, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTGS2, PTPN1, SRC, TRPV1, TYR 4.1157
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, TRPV1 4.02212
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HTR2A, HTR4, HTR5A, IDO1, KDR, MIF, MMP2, MMP9, NR3C1, PIM1, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 2.6439
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, F2, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS2, PTPN1 2.46794
[CC] GO:0031233 None CA4, F10, F3 2.27093
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, TNKS, TYR, XDH 18.9297
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.9297
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 16.2257
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2257
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2257
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.1817
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.1817
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.7609
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 13.5447
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.004
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 11.8648
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, NR3C1, PPARA, PPARG, TRPV1 10.862
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.6056
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 10.566
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, NR3C1, PPARA, PPARG, TRPV1 9.95778
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, F2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 9.75707
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, NR3C1, PPARA, PPARG, TRPV1 9.57138
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PPARG, PTPN1, TNKS 9.25912
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.19589
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 8.9186
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, NR3C1, PPARA, PPARG, TRPV1 8.5774
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 8.4539
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 8.4539
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.08701
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, IDO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 7.43928
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 7.0214
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 6.72372
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 6.71347
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.70832
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARG, TRPV1 6.63613
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, F3, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARG, TRPV1 6.63613
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, PPARG, TRPV1 6.56158
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, FLT3, HSP90AA1, HSP90AB1, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, PPARA, PPARG, SRC, TRPV1 5.95028
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1 5.94371
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG 5.72522
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 5.62511
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B2, HSD17B1, IDO1, PTGS2, SRC, XDH 5.19811
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS2, TYR 5.19066
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.03118
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG 4.84816
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG 4.84816
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 4.78593
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 4.70496
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.56578
[MF] GO:0004930 None ADORA1, ADORA3, CNR1, CNR2, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARG 4.37422
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.25962
[MF] GO:0030235 nitric-oxide synthase regulator activity ESR1, HSP90AA1, HSP90AB1 3.50423
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.22206
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.16413
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, HSP90AA1, HSP90AB1, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 3.14481
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.12154
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.10863
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.08323
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, HSP90AA1, HSP90AB1, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.99499
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.88246
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 2.85385
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.81923
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.81923
[MF] GO:0003845 None HSD11B1, HSD11B2 2.81923
[MF] GO:0008389 None CYP2A13, CYP2A6 2.81923
[MF] GO:0071886 None HTR2A, HTR2C 2.81923
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.69252
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MET, MMP12, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TRPV1, XDH 2.60626
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F2, F3, MMP1, MMP12, MMP2, MMP9 2.57251
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MET, MMP12, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TRPV1, XDH 2.5494
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.53758
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, IDO1, PTGS2 2.47749
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.44866
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.44866
[MF] GO:0004949 None CNR1, CNR2 2.44866
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.44866
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.44866
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MIF, MMP9, PPARG, PTGS2, TRPV1, TYR, XDH 2.27093
[MF] GO:0001047 None ESR1, ESR2, ESRRB, MMP12, NR3C1, PPARG 2.21318
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, KDR, NR3C1 2.21318
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.19702
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.19702
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.19702
[MF] GO:0004252 None F10, F2, F3, MMP1, MMP12, MMP2, MMP9 2.17493
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.08516
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.03112
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.03112
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 2.02131


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.0321
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, ALOX12, HTR2A, PTGS2, HTR5A, HTR4, HTR6, HTR7, ALOX5 16.0782
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, TRPV1, HTR2A, NR3C1, F2, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1 14.1129
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.9226
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.9423
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 6.027
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.2286
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, CDK6, HSP90AB1, FLT3, MMP1, MMP2, BCL2, PPARG, PTGS2, MMP9, MET, IGF1R 5.6404
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.2251
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, HTR1E, HTR1D, ADORA1, HTR1A, HTR1B, PPARA, HTR4 5.5328
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, MMP9, ESR1, ESR2 5.5002
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2C, ALOX12, TRPV1, HTR2A 4.3618
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.0597
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 3.9519
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.679
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.0602
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.5178
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.8626
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 3.9606
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12, PTGS2 3.0096
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.679
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 HSP90AA1, CDK6, HSP90AB1, KDR, BCL2, MET, IGF1R 2.4613
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 2.8486
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.5945
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, BCL2, IGF1R 2.5119
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.35
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, CDC25B, IGF1R 2.3847
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A 2.5147
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.3165
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.1213
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, MET, IGF1R 2.0511
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.8739
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.1213
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.8739
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.0446
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8739
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.5945
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.3063
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 1.6897
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2, F3 1.782
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.6158
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.1548
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.345
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.336
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.0938
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.8063
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, BCL2 1.0506
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.8841
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PPARG, IGF1R 0.8658
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.8164
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 0.8248
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.7854
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.7867
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1579
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.7862
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7147
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.0889
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.0725
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7582
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7582
AMPK signaling pathway_Homo sapiens_hsa04152 PPARG, IGF1R 0.7335
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.7582
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.6981
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9893
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7335
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.0682
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1 0.9923
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.6202
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6893
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.6844
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1718
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.1579
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5541
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.5921
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5039
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.0488
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.4989
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1506
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2 0.4848
Huntington's disease_Homo sapiens_hsa05016 PPARG 0.2406
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2462
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2572
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2462
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3028
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.2997
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3136
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3136
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3124
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3233
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.3233
Platelet activation_Homo sapiens_hsa04611 SRC 0.3352
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3233
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3364
Axon guidance_Homo sapiens_hsa04360 MET 0.3281
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3352
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3913
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3913
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4019
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4143
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4019
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4134
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4138
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4143
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4143
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.414
Peroxisome_Homo sapiens_hsa04146 XDH 0.4239
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4631
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4631
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4619
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4707
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.4847
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4847
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4721
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4847
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4913
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4847
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.4848
Shigellosis_Homo sapiens_hsa05131 SRC 0.4847
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5045
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5361
Malaria_Homo sapiens_hsa05144 MET 0.547
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5541
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6212
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5505
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5541
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6087
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4963
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.586
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.6423
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.6981
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6844
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8173
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6981
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7156
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7113
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.8248
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0597
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8147
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.8841
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1579


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)