TCM Prescription: Fu Fang Shi Hu Tablets



Prescription Description
Prescription IDTCMF3952
Pinyin NameFu Fang Shi Hu Pian
Chinese Name复方石斛片
English NameFu Fang Shi Hu Tablets
Function Description视瞻昏渺
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH1294 Cornu saigae tataricae 羚羊角 TCMH1294
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1997 Bubalus bubalis 水牛角 TCMH1997 GBMA0080-06
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH1933 Herba dendrobii 石斛 TCMH1933
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2084 Asparagus cochinchinensis 天冬 TCMH2084 ITSAJ4142-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1024 Tribulus terrestris 蒺藜 TCMH1024 ITSAJ4258-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH1698 Semen celosiae 青葙子 TCMH1698
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EPHX2, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MAOA, MAOB, MET, NISCH, NR1H4, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, TRPV1, XDH 14.1228
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 13.6321
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, EPHX2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, NR1H4, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1, TRPV1 13.6321
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, EPHX2, FABP3, FUT7, GBA2, GLO1, NISCH, NR1H4, PDE5A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 11.8347
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 11.8347
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 11.4339
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 11.2616
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, MAOB, NQO2, PHF8, PTGS1, PTGS2, TBXAS1, TYR, XDH 10.8795
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 10.3843
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.0041
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, MAOB, MMP2, MMP9, NR1H4, NR3C1, PIK3CA, POLB, PPARA, PTGS2, RORC, SRC, TRPV1, TYR 10.0041
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4 9.84497
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.35532
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 9.2848
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.24113
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MAOB, MET, MMP1, MMP2, NQO2, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 9.14732
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MAOB, MMP2, NR1H4, NR3C1, PIK3CA, POLB, PPARA, PTGS2, RORC, SRC, TRPV1, TYR 8.66678
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, DYRK1B, DYRK2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 8.43274
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 8.24165
[BP] GO:0042221 response to chemical ABCB1, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EPHX2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MAOB, MMP2, MMP9, NR1H4, NR3C1, PIK3CA, POLB, PPARA, PTGS2, RORC, SRC, TERT, TRPV1, TYR 8.20194
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, EPHX2, FABP3, FABP4, FUT7, GBA2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 8.01829
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, KIT, MAOB, MMP2, NR1H4, NR3C1, PPARA, PTGS2, SRC, TRPV1 7.85724
[BP] GO:0007193 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 7.82495
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 7.82495
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, THRA, TOP2A, TRPV1, XDH 7.58228
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EPHX2, FABP3, GBA2, GLO1, NR1H4, PPARA, PTGS1, PTGS2, TBXAS1 7.45014
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, THRA, TOP2A, TRPV1, XDH 7.41469
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 7.2559
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 7.16122
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.14443
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, DYRK1B, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.14225
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.11043
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, DYRK1B, DYRK2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.10931
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, MAOB, NR1H4, NR3C1, PTGS2, RORC, SRC, TYR 6.92043
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MAOB, MMP9, PTGS2, SRC, TERT 6.91767
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PPARA, RORC, SRC, THRA, THRB 6.87694
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, MAOB, NR3C1, PPARA, PTGS2, SRC, TRPV1 6.85394
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GRM1, HCAR2, KDR, KIT, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.82651
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GRM1, HCAR2, KDR, KIT, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.78558
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, KIT, MMP2, NR1H4, NR3C1, PIK3CA, PTGS2, RORC, SRC, TRPV1 6.69276
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, KIT, MMP2, MMP9, NR1H4, NR3C1, PIK3CA, PTGS2, RORC, SRC, TERT, TRPV1 6.67342
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, MMP12, MMP9, NISCH, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, TERT, THRA, TNKS, TNKS2, XDH 6.67229
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PIM1, PPARA, RORC, SRC, THRA, THRB 6.67229
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, DYRK1B, DYRK2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 6.62501
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MMP9, NR1H4, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, THRA, TOP2A, TRPV1, XDH 6.55897
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, MMP12, MMP9, NISCH, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, TERT, THRA, TNKS, TNKS2, XDH 6.55897
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TBXAS1, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 6.50065
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, KIT, MET, SRC 6.40335
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, KIT, MET, SRC 6.32952
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, EPHX2, NQO2, PTGS1, RORC 6.30849
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EPHX2 6.2308
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, MAOB, NR3C1, PTGS2, RORC, SRC, TRPV1, TYR 6.19556
[BP] GO:0007188 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 6.13695
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX12, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DYRK2, F3, GRIK5, GRM5, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NISCH, NR1H4, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TERT, THRA, TRPV1 5.99946
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, NISCH, PTGS2 5.99264
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, NISCH, PTGS2 5.99264
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DAO, GBA2, MAOA, MAOB, NR1H4, TYR 5.9838
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX12, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DYRK1A, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM8, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NISCH, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.96664
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, NR1H4, PPARA, SLC1A1, TRPV1 5.9343
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CHRM5, CYP1A1, EPHX2, FABP3, FLT3, HCAR2, KIT, NR1H4, PPARA, PTGS2, RORC, SRC, THRA 5.88994
[BP] GO:0006940 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, KIT, PTGS2 5.88994
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PPARA, RORC, SRC, THRA, THRB 5.86974
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 5.83152
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DNMT1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PDE5A, PIM1, PTGS1, PTGS2, SRC, TERT, XDH 5.81026
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, EPHX2, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, NR1H4, PIK3CA, PIK3CB, POLA1, POLB, SRC, TERT, TRPV1 5.76042
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM8, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NISCH, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.74296
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, DYRK1B, DYRK3, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, KDR, KIT, MAOB, MET, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTGS2, PTPRS, RORC, SRC, TERT, THRA, THRB, TNKS2, TOP2A, TYR 5.72662
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, EPHX2, FABP3, GBA2, GLO1, NR1H4, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 5.70539
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PDE5A, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, PTPRS, SRC, TNKS, XDH 5.67894
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK2, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, KIT, MMP2, MMP9, NR1H4, NR3C1, PIK3CA, POLA1, POLB, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1 5.55503
[BP] GO:0007187 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.5038
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, EPHX2, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, THRA, THRB, TNKS2, TRPV1, TYR 5.48817
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.46315
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.4127
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GRM1, KDR, KIT, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.41081
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DNMT1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR1H4, NR3C1, PIK3CA, PTGS2, RORC, SRC, TRPV1 5.29241
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, HCAR2, KDR, NR1H4, PIK3CB, PTGS2, SRC, TNKS, TNKS2, TRPV1 5.25042
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PDE5A, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, PTPRS, SRC, TNKS, XDH 5.22622
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DNMT1, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, IGF1R, KDR, KIT, MET, MMP2, MMP9, NISCH, NR1H4, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TRPV1 5.15626
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TNKS 5.09376
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.08183
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.08183
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PPARA, RORC, THRA, THRB 5.05432
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, EPHX2, FABP3, GBA2, GLO1, NR1H4, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 5.01885
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, DYRK3, GLO1, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 5.00197
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, DYRK3, GLO1, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 5.00197
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK2, EPHX2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MAOB, MMP12, MMP2, MMP9, NR1H4, NR3C1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, THRA, TOP2A, TRPV1, TYR 4.93551
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DAO, EPHX2, FABP3, GBA2, GLO1, NR1H4, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 4.89807
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4 4.88806
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, DYRK2, DYRK3, ESR1, F3, FLT3, GRM1, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.86466
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CLK1, CYP1A1, ESR1, FLT3, KIT, MET, PIK3CB, PIM1, POLA1, SRC, TYR 4.86245
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.85304
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, NISCH, PTGS2, SRC, TERT 4.84995
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, F3, FLT3, GRM1, KDR, KIT, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.83618
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, GRM1, HCAR2, KIT, PDE5A, PTGS2, SLC1A1, THRA, THRB, TRPV1 4.79955
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, NISCH, PTGS2, SRC, TERT 4.7486
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PHF8, PIK3CA, POLB, PPARA, PTPRS, SRC, THRA, TYR 4.60993
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.60816
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, PDE5A, PTGS2, SLC1A1, THRA, THRB 4.59822
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.58895
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.58895
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, NR1H4, PPARA, SLC1A1, TRPV1 4.55505
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, NISCH, PTGS2, SRC, TERT 4.54246
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.48146
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.43002
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 4.36872
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.34713
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DAO, EPHX2, FABP3, FABP4, FUT7, GBA2, MAOA, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CB, SRC, XDH 4.33082
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 4.31646
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, CHRM5, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.29916
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 4.29364
[BP] GO:0019371 None CBR1, PTGS1, PTGS2, TBXAS1 4.26545
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, NISCH, PTGS2, SRC, TERT 4.26545
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, CHRM5, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.24348
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, CYP3A4, DAO, MAOA, MAOB 4.22442
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, MAOB, NR3C1, POLB, PTGS2, SRC, TRPV1 4.22442
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, ESRRB, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.2075
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PPARA, RORC, THRA, THRB 4.2075
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, DYRK1B, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MAOB, MMP9, PHF8, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPRS, RORC, SRC, THRA, TYR 4.16975
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MAOB, MMP9, PTGS2, TERT 4.16081
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX12, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, ESR1, ESRRA, ESRRB, F3, GRM1, HCAR2, KDR, KIT, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIM1, PTGS2, PTPRS, SLC1A1, SRC, TERT, THRA, THRB, TNKS2, TRPV1, XDH 4.15997
[BP] GO:0006937 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, KIT, PDE5A, PTGS2 4.13105
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.08524
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DAO, EPHX2, MAOA, MAOB 4.05895
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 3.97667
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, DYRK3, GLO1, IGF1R, KDR, MMP9, NR1H4, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 3.95133
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, EPHX2, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, NR1H4, PIK3CA, PIK3CB, TRPV1 3.93232
[BP] GO:0007200 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 3.93232
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DAO, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HASPIN, IGF1R, KDR, KIT, MAOA, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PHF8, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.93232
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.92348
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 3.84829
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, DYRK1B, DYRK2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.84812
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CLK1, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, DYRK1B, DYRK2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.833
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, NR1H4, SRC, TNKS, TOP2A 3.80929
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, DYRK2, GRIK5, GRM5, HCAR2, MAOB, MMP12, MMP9, NR1H4, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TERT, THRA, TRPV1 3.78713
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC, TRPV1 3.78108
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, HASPIN, TERT, TNKS, TNKS2 3.78108
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8, PTGS2 3.78108
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, PHF8 3.78108
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, GRM1, KDR, KIT, MET, MMP12, MMP2, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.64652
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 3.62932
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 3.62932
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, EPHX2, KIT, NR1H4, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2, TRPV1 3.59857
[BP] GO:0003008 None ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, EPHX2, GRM1, GRM5, GRM8, HSD11B2, KIT, PDE5A, PIK3CA, PTGS2, SRC, THRA, THRB, TRPV1, TYR 3.57425
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, FLT3, GRM1, KDR, KIT, PDE5A, PIK3CB, PTPN1, SRC, XDH 3.56035
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 3.53399
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.53094
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EPHX2, MAOB 3.52677
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.48132
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, APP, DNMT1, ESR1, FLT3, GRM5, IGF1R, KIT, MMP2, NR1H4, NR3C1, PTGS2, SRC, TRPV1 3.42094
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.37284
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.36759
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.36759
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DYRK2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP2, MMP9, NR1H4, PIK3CA, PIK3CB, PTPN1, SRC, TNKS, TNKS2, TRPV1 3.36416
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, ALOX12, APP, AXL, BCL2, CA2, CHRM3, CYP1B1, ESRRB, F3, HCAR2, KDR, KIT, MET, MMP12, MMP9, NR1H4, PDE5A, PIM1, PTGS2, SLC1A1, SRC, TERT, TRPV1 3.36006
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, MAOB, NR3C1, PTGS2, SRC 3.33721
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM3, EPHX2, PTGS2, SRC 3.33721
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, KIT, NR1H4, SRC 3.31853
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.26113
[BP] GO:0061097 None ADORA1, ADRA2A, ADRA2C, APP, GRM5, PTPN1 3.25466
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, NR1H4, SRC 3.24134
[BP] GO:0061098 None ADORA1, ADRA2A, ADRA2C, GRM5, PTPN1 3.24134
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EPHX2, KDR, MAOB, POLB, SRC 3.24134
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CLK1, CSNK2A1, CYP1B1, CYP2D6, DNMT1, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.23969
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADRA2A, ALOX12, APP, CDK6, CYP19A1, DYRK1A, DYRK3, ESR1, F3, FABP4, IGF1R, MET, MMP12, MMP2, NR1H4, PPARA, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 3.22477
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GRM1, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, SRC, TERT, THRA, TNKS, TNKS2, XDH 3.22308
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TRPV1, XDH 3.20467
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.16908
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TBXAS1, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 3.16563
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.16477
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, MAOB, NR3C1, PTGS2, SRC 3.16243
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 3.14931
[BP] GO:0018958 None AKR1B1, BCL2, DAO, MAOA, MAOB, TYR 3.14931
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.12929
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, NR3C1, PTGS2, SRC, TRPV1 3.12303
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR1H4, NR3C1, PHF8, PPARA, PTGS2, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1 3.12303
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, KIT, PPARA, RORC, SRC, TOP2A 3.10014
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, HSD11B2, IGF1R, PPARA, PTGS2, SRC, TRPV1 3.10014
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, GRM1, HSD11B2, KIT, MMP2, POLB, PPARA, PTGS2, SRC, TERT, THRA, TRPV1, TYR 3.08001
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, NR1H4, PIK3CB, PTGS2, TNKS, TNKS2 3.07211
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, NR1H4, PPARA, PTGS2, SRC 3.06286
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, ESRRB, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.05574
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, F3, FLT3, GRM1, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, TERT, THRA, TNKS, TNKS2, XDH 3.05515
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.05515
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.05515
[BP] GO:0090257 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, KIT, PDE5A, PTGS2 3.05515
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, ADRA2C, FLT3, GRM5, KIT, PTPN1, SRC 3.05515
[BP] GO:0097746 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM3, EPHX2, PTGS2 3.05515
[BP] GO:0035296 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM3, EPHX2, PTGS2 3.05515
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PTGS2, SRC, TERT 3.03204
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.0303
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.02406
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.02406
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, APP, FLT3, GRM5, KIT, PTPN1, SRC 3.02303
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.0212
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.01434
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 2.99941
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 2.99941
[BP] GO:0018210 peptidyl-threonine modification BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 2.98426
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, F3, FLT3, GRM1, GRM5, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.96042
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.95108
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.95108
[BP] GO:0045934 None ADRA2A, APEX1, AURKB, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, MMP12, NR1H4, NR3C1, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TRPV1 2.94904
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, FLT3, GRM1, GRM5, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC 2.94729
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, NR1H4, PPARA, PTGS2, SRC, TRPV1, TYR 2.94729
[BP] GO:0045932 None ADORA1, ADRA2C, PDE5A, PTGS2 2.94001
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA, THRA 2.91755
[BP] GO:0050880 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM3, EPHX2, PTGS2 2.91161
[BP] GO:0035150 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM3, EPHX2, PTGS2 2.89183
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, FLT3, GRM1, GRM5, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.88155
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 2.87876
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, IGF1R, MET, MMP12, MMP9, NR1H4, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TRPV1, XDH 2.87214
[BP] GO:0007154 None ADORA1, ADRA2C, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1, TRPV1 2.8376
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 2.82619
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DAO, EPHX2, MAOA, MAOB, PDE5A, XDH 2.82523
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, MAOB, NR3C1, PTGS2 2.79017
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, IGF1R, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC 2.77896
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 2.77575
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, PIK3CB, THRA 2.76859
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CLK1, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, DYRK1B, DYRK2, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GRM1, GRM5, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.75116
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.74069
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.73511
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX12, ALOX15, BCL2, CDK6, CYP19A1, DYRK1A, DYRK3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 2.72741
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.71905
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS1, PTGS2 2.71905
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C, APP 2.71905
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, SRC, TNKS, TNKS2, TRPV1 2.70985
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, FLT3, GRM1, GRM5, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC 2.70625
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, GRM5, IGF1R, MMP2, NR1H4, PTGS2, SRC, TRPV1 2.70163
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 2.70048
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, FLT3, GRM1, IGF1R, KDR, KIT, PDE5A, PIK3CB, PTPN1, SRC, XDH 2.69005
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR1H4, NR3C1, PHF8, PPARA, PTGS2, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1 2.67572
[BP] GO:0019229 None ADRA2A, ADRA2C, CHRM1, CHRM3, PTGS2 2.66725
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, GRM1, KIT, PDE5A, PIK3CB, PTPN1, SRC 2.64378
[BP] GO:0008217 None ADORA1, EPHX2, HSD11B2, NISCH, PPARA, PTGS1, PTGS2 2.63081
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.63081
[BP] GO:0003013 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM3, EPHX2, PTGS2, SRC 2.62625
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.62625
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 2.62625
[BP] GO:0008050 None THRA, THRB 2.62625
[BP] GO:0009115 None AOX1, XDH 2.62625
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.62625
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.62625
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.62625
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.62625
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, NR1H4, PPARA, PTGS2, SRC, TRPV1, TYR 2.62481
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC 2.59955
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 2.59804
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, IGF1R, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.594
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, NISCH 2.59174
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, GRM1, IGF1R, KIT, PDE5A, PIK3CB, PTPN1, SRC 2.57368
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 2.55948
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.54783
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC, TERT, TNKS 2.54783
[BP] GO:0010907 None DYRK2, ESRRB, PPARA, SRC 2.54783
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.54783
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 2.54783
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.54783
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 2.53141
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.5201
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.51239
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.51239
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.50867
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CLK1, CSNK2A1, CYP1B1, DNMT1, DYRK1A, DYRK1B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.50727
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DAO, EPHX2, FABP3, FABP4, FUT7, GBA2, MAOA, MAOB, PDE5A, XDH 2.49953
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA2A, ADRA2C, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, GRM1, GRM5, KIT, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC, TERT, TNKS, XDH 2.48906
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, IGF1R, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC 2.48481
[BP] GO:0030168 platelet activation ADRA2A, ADRA2C, AXL, PIK3CA, PIK3CB, SRC 2.47736
[BP] GO:2001251 None DNMT1, PHF8, SRC, TNKS, TNKS2, TOP2A 2.45915
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, DAO, TYR 2.45915
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 2.45915
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, GRM5, IGF1R, MMP2, NR1H4, PTGS2, SRC, TRPV1 2.45915
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.45629
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.43982
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, PTGS2, SRC, THRA, THRB, TOP2A 2.43915
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9, THRA 2.4001
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, HCAR2, MMP12, NR1H4, PTGS2, SRC, TERT, TRPV1 2.38447
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, DYRK3, ESR1, IGF1R, MET, MMP9, NR1H4, PTGS2, PTPN1, SRC, XDH 2.38405
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 2.37891
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.36394
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.36137
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, NR1H4, NR3C1, PHF8, PPARA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A 2.35753
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 2.32827
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, EPHX2, ESR1, GRIK5, GRM1, GRM5, NR1H4, PIK3CA, PIK3CB, POLA1, TRPV1 2.32766
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, BCL2, DYRK1A, DYRK3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 2.30808
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 2.29903
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, BCL2, DYRK1A, DYRK3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 2.29299
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 2.29135
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.28586
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, F3, KDR, KIT, PTGS2, TERT 2.27799
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.27135
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, DYRK1B, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, NR1H4, NR3C1, PHF8, PPARA, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A 2.24282
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, NR1H4, PPARA, SLC1A1, TRPV1 2.24282
[BP] GO:0099566 None GRM1, GRM5 2.24282
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.24282
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.24282
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.24282
[BP] GO:0046110 None AOX1, XDH 2.24282
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.24282
[BP] GO:0006808 regulation of nitrogen utilization BCL2, NR1H4 2.24282
[BP] GO:0007267 None ADORA1, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.2384
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 2.22685
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.22646
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.22646
[BP] GO:0045986 None ADORA1, ADRA2C, PTGS2 2.22646
[BP] GO:0030258 lipid modification ALOX12, CYP1A1, CYP3A4, EPHX2, KIT, MET, PIK3CA, PIK3CB 2.21714
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, ADRA2C, APP, CA2, CHRM1, DYRK2, HCAR2, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 2.21247
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, BCL2, CDC25B, ESR1, F3, FLT3, GRM1, GRM5, KIT, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC, TERT, TNKS, XDH 2.2084
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, MAOA, MAOB 2.20365
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.19276
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, ADRA2C, GRM1, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.19246
[BP] GO:0006584 None AKR1B1, DAO, MAOA, MAOB 2.17466
[BP] GO:0009712 None AKR1B1, DAO, MAOA, MAOB 2.17466
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.15428
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5 2.14803
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DYRK2, EPHX2, HSD11B2, KIT, MMP2, MMP9, NR1H4, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TERT, THRA, TOP2A, TRPV1 2.13134
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, KIT, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.12274
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, NR1H4, PTGS2, SRC 2.11941
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.10358
[BP] GO:0042391 None ADORA1, APP, BCL2, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 2.09454
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, GRIK5, MAOA, MAOB, PTGS2, SLC1A1, TRPV1 2.09051
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.08601
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, EPHX2, ESR1, GRIK5, GRM1, GRM5, NR1H4, PIK3CA, PIK3CB, TRPV1 2.0829
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.06135
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DAO, EPHX2, FABP3, FABP4, GBA2, MAOA, MAOB, PDE5A, PIK3CB, SRC, XDH 2.04098
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, KIT, MET, MMP9, NR1H4, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TNKS, TRPV1, XDH 2.0308
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.02851
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.02308
[BP] GO:0007617 None APP, THRA, THRB 2.02308
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA2A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC, TRPV1 4.82403
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 4.57459
[CC] GO:0044456 None ACHE, ADORA1, ADRA2C, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SRC, TRPV1 4.53928
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA4, GRIK5, GRM1, GRM5, HASPIN, IGF1R, KDR, KIT, MAOA, MAOB, MMP12, MMP2, MMP9, NISCH, NQO2, NR3C1, PHF8, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 4.31646
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, ESR1, F3, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MAOA, MAOB, MET, MMP2, NISCH, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SLC1A1, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR 4.13585
[CC] GO:0043005 None ADORA1, ADRA2C, APP, BACE1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC, TUBB3 3.80929
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CDK6, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HASPIN, IGF1R, KDR, KIT, MAOA, MAOB, MMP12, MMP2, MMP9, NISCH, NQO2, NR3C1, PHF8, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 3.80545
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AXL, BACE1, CA4, CHRM1, CHRM2, CHRM3, CHRM5, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTPRS, SLC1A1, TRPV1 3.66376
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX12, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, F3, FLT3, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, MMP2, NISCH, PIK3CA, PIK3CB, PIM1, PTPN1, PTPRS, SLC1A1, SRC, TERT, TRPV1 3.65264
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 3.26489
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MAOB, MET, MMP12, MMP2, MMP9, NISCH, NQO2, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TBXAS1, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 3.05515
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AXL, BACE1, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTPRS, SLC1A1, TRPV1 3.04806
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, PTGS2, PTPRS, SLC1A1, SRC, TRPV1 2.85095
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, DYRK2, DYRK3, EPHX2, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MAOA, MAOB, MMP2, MMP9, NISCH, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TERT, THRA, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.75791
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FLT3, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 2.6808
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 2.62481
[CC] GO:0120025 None ADORA1, ADRA2C, AKR1B1, APP, BACE1, CA2, CDK6, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, PTPRS, SRC, TUBB3 2.62481
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, TBXAS1 2.59866
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MAOA, MAOB, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, PTPRS, SLC1A1, SRC, TBXAS1, TRPV1, TYR 2.50376
[CC] GO:0098793 None ADORA1, ADRA2C, APP, CHRM1, CHRM2, CHRM3, GRIK5 2.39821
[CC] GO:0042995 cell projection ADORA1, ADRA2C, AKR1B1, APP, BACE1, CA2, CDK6, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, PTPRS, SRC, TUBB3 2.32766
[CC] GO:0097458 None ADORA1, ADRA2C, APP, BACE1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS1, PTGS2, PTPRS, SRC, TRPV1, TUBB3 2.27486
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AURKB, BACE1, BCL2, CA4, CA5A, CA5B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, GRIK5, GRM1, HASPIN, IGF1R, KDR, KIT, MAOA, MAOB, MMP12, MMP2, NR3C1, PHF8, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.16225
[CC] GO:0014069 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.00559
[CC] GO:0099572 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.00559
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DYRK2, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR1H4, NR3C1, PHF8, PIM1, PPARA, PTPN1, RORC, TBXAS1, THRA, THRB, TNKS, TYR, XDH 23.6389
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD17B1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TBXAS1, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 18.9363
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, F3, FLT3, FUT7, GBA2, GLO1, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 18.5872
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.1456
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, MAOB, NQO2, PHF8, PTGS1, PTGS2, TBXAS1, TYR, XDH 12.9958
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR1H4, NR3C1, PDE5A, PHF8, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TBXAS1, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 12.0406
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR1H4, NR3C1, PDE5A, PHF8, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TBXAS1, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 11.3677
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR1H4, NR3C1, PHF8, PPARA, PTPN1, RORC, THRA, THRB, TNKS 11.0956
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 10.478
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PHF8, TBXAS1, XDH 10.2735
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, PPARA, RORC, THRA, THRB, TRPV1 9.23131
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.08987
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 8.81745
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PPARA, RORC, THRA, THRB 8.79656
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, PPARA, RORC, THRA, THRB, TRPV1 8.20194
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PHF8, PTGS1, PTGS2, TBXAS1, TYR 8.20194
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, HSD11B2, HSD17B1, MAOB, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 8.18253
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 8.12384
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 8.12384
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 8.01816
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, PPARA, RORC, THRA, THRB, TRPV1 7.97074
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 7.68077
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 7.58249
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP2A, TRPV1 7.45014
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 7.41469
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR1H4, NR3C1, RORC 7.35201
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.12352
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, PPARA, RORC, THRA, THRB, TRPV1 6.98612
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 6.98445
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, KIT, MET, SRC 6.52756
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 5.83152
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 5.69068
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, HASPIN, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAOB, MET, NQO2, NR1H4, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, SLC1A1, SRC, TOP2A, TRPV1, TUBB3, XDH 5.46173
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 5.3846
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NQO2, NR3C1, THRA, THRB 5.06343
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 5.03154
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC 4.86555
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CLK1, CSNK2A1, DAO, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FABP3, FABP4, FLT3, HASPIN, HSD17B1, IGF1R, KDR, KIT, MAOB, MET, NISCH, NQO2, NR1H4, PDE5A, PIK3CA, PIK3CB, PIM1, PTPRS, SLC1A1, SRC, TOP2A, TRPV1, TUBB3, XDH 4.68937
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NISCH, NR1H4, NR3C1, PPARA, RORC, TRPV1 4.67473
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.64814
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC, TERT 4.60037
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TOP2A, TRPV1, TUBB3, XDH 4.569
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TOP2A, TRPV1, TUBB3, XDH 4.56715
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 4.55226
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 4.44855
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ADRA2A, ADRA2C, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAOB, MET, MMP12, NQO2, NR1H4, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, THRA, THRB, TOP2A, TRPV1, TUBB3, XDH 4.29916
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM3, CHRM5, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, TRPV1 4.26545
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM3, CHRM5, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, TRPV1 4.26545
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 3.93863
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAOB, MET, MMP12, NQO2, NR1H4, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, THRA, THRB, TOP2A, TRPV1, TUBB3, XDH 3.87136
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, AOX1, APP, BCL2, CSNK2A1, DYRK1A, EPHX2, ESR1, ESR2, FLT3, GRIK5, IGF1R, KDR, KIT, MAOB, MET, MMP9, NISCH, NQO2, PTGS2, TERT, TOP2A, TRPV1, TYR, XDH 3.87063
[MF] GO:0008227 None ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM5 3.84829
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.65693
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.42444
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 3.37102
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOA, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NR1H4, NR3C1, PDE5A, PHF8, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TBXAS1, TERT, THRA, THRB, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 3.16613
[MF] GO:0004887 None NR1H4, THRA, THRB 3.16477
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.14139
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.12303
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, EPHX2, PDE5A, PTPN1, PTPRS 2.95108
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 2.87876
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 2.87154
[MF] GO:0016803 ether hydrolase activity ALOX12, ALOX15, EPHX2 2.87154
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PHF8, PTGS1, PTGS2 2.86957
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5, PDE5A 2.84509
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.82619
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 2.82619
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.71905
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 2.67006
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.63081
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.62625
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.62625
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.62625
[MF] GO:0003845 None HSD11B1, HSD11B2 2.62625
[MF] GO:0008389 None CYP2A13, CYP2A6 2.62625
[MF] GO:0016801 None ALOX12, ALOX15, EPHX2 2.54783
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, EPHX2, PDE5A, POLA1, PTPN1, PTPRS 2.50727
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, TRPV1 2.39677
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.33721
[MF] GO:0050660 flavin adenine dinucleotide binding AOX1, DAO, MAOB, NQO2, XDH 2.31117
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, PTPRS, SRC, TOP2A, TRPV1, TUBB3 2.2933
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, ADRA2C, AOX1, BCL2, EPHX2, FLT3, KIT, MAOB, NQO2, PTGS2, TERT, TOP2A, TYR, XDH 2.2928
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SRC, THRA 2.2928
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, SRC, THRA 2.27691
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, TRPV1 2.27377
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, HASPIN, PIK3CA, PIM1 2.27377
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.24282
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.24282
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.24282
[MF] GO:0004938 None ADRA2A, ADRA2C 2.24282
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.24282
[MF] GO:0099583 None GRM1, GRM5 2.24282
[MF] GO:0016641 None DAO, MAOA, MAOB 2.22646
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.13933
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, TRPV1 2.06952
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.02308
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.02308
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.0088


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 15.9698
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, THRB, CHRM1, THRA, GRIK5, CHRM5, TRPV1, NR3C1, ADRA2C, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 12.6151
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, MAOB, MAOA, ALOX15, AKR1B1, ALOX12, PTGS2, CYP3A4, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, ALOX5, HSD17B1, HSD17B2, AOX1, XDH, CBR1, EPHX2, TYR, POLA1, CYP2A6, DAO, AKR1B10, TBXAS1, CYP1A2, CYP1A1, ALPL 8.4318
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.53
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 7.8499
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.8499
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, EPHX2, ALOX15, TBXAS1, ALOX12, PTGS2, PTGS1 7.201
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.5092
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOB, MAOA, CYP2D6, ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 6.4088
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, ESR2 5.7129
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, BCL2, PIK3CB 5.3992
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.7129
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 5.342
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, MAOA, CYP2D6, CYP1A2, AOX1, CYP3A4 5.6297
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.8077
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, MMP1, MMP2, KIT, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 4.4747
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 4.5361
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 4.9662
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 4.5835
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 3.6655
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, IGF1R 3.6332
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, KIT, GRM8, PIK3CB, GRM1 3.7406
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 3.752
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 3.6655
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PDE5A, PIK3CB, ADRA2C, ADRA2A 3.4492
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET 3.5184
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 THRB, PIK3CA, THRA, SRC, PIK3CB, ESR1 3.4166
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 3.5659
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 3.4425
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.4276
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 3.0289
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KIT, KDR, PIK3CB, MET, IGF1R 2.9465
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 2.983
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB 2.9205
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.3975
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.1124
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 2.9154
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 2.8649
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 2.5815
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 2.5564
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 2.5707
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, IGF1R 2.6209
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KIT, KDR, PIK3CB, MET, IGF1R 2.1509
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.1244
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOB, MAOA, GRIA4 2.5906
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, MAOA, AOX1, TYR 3.4874
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.2173
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.2971
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOB, MAOA 3.0289
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.0952
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.3966
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, TUBB3, GRM1 2.2274
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 1.9504
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 1.9431
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.0316
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.5702
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, NR1H4, CYP3A4 2.5411
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, PIK3CA, SRC, PIK3CB 1.7655
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 1.862
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 1.862
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOB, MAOA, GRIA4 1.7696
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, GRM1, IGF1R 1.7352
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 1.7131
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.109
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 1.6651
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 1.5243
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.4394
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.1654
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.173
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.193
Phagosome_Homo sapiens_hsa04145 TUBB3 0.2148
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.2314
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.2345
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.3774
Axon guidance_Homo sapiens_hsa04360 MET 0.2639
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.2708
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.0793
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.3168
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.2072
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, TERT, PIK3CB 0.9809
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.0078
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.0248
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3265
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 0.9586
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.1173
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.0828
Purine metabolism_Homo sapiens_hsa00230 POLA1, PDE5A, XDH 0.8867
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.4859
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.1846
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3437
Alcoholism_Homo sapiens_hsa05034 MAOB, MAOA 0.4853
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.4884
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.5131
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.5095
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.4439
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.3552
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.3563
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 0.8371
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6059
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.3563
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.3563
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.6189
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.4512
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3563
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.3563
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.3622
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.6308
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.7737
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 1.7924
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 1.7737
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 1.6929
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.6664
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 1.9183
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 1.8579
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 1.7737
Peroxisome_Homo sapiens_hsa04146 DAO, EPHX2, XDH 1.5524
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.3843
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.7587
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 1.8245
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 0.7688
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.7865
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.7688
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.7865
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 0.7828
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4088
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 0.8216
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.83
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.7943
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.8097
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.8055
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4209
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.8474
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4232
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 0.8867
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4417
Shigellosis_Homo sapiens_hsa05131 SRC 0.4417
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO, MAOB, MAOA 2.0316
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4417
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 0.9642
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 0.9586
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.0064
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 0.9809
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.2762
Legionellosis_Homo sapiens_hsa05134 CLK1 0.4884
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.0064
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.4884
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.0828
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.1162
Malaria_Homo sapiens_hsa05144 MET 0.5197
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.0876
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5296
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO, MAOB, MAOA 2.2524
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5246
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.1784
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5296
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.5906
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5456
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.5402
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.1851
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.22
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.2626
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.5792
DNA replication_Homo sapiens_hsa03030 POLA1 0.6139
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.3534
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6633
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5412
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6805
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.67
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7176
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.4824
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5028
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4302
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7058
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7324
Histidine metabolism_Homo sapiens_hsa00340 MAOB, MAOA 1.7073
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.83
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB, MAOA 1.9183
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.6887
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9122
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.197


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)