TCM Prescription: Er Tong Qing Re Dao Zhi Pills



Prescription Description
Prescription IDTCMF3934
Pinyin NameEr Tong Qing Re Dao Zhi Wan
Chinese Name儿童清热导滞丸
English NameEr Tong Qing Re Dao Zhi Pills
Function Description伤食, 积滞, 疳病
IndicationsInfantile malnutrition disorder, Dyspepsia
Disease ICD-11 Category SE37 [Infantile malnutrition disorder (TM1), 疳病 (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
Human Tissues Associated with IndicationIntestine, Stomach, Spleen
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1026 Gallus gallus domesticus 鸡内金 TCMH1026 ACLB009-06
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH1072 Semen arecae preparata 焦槟榔 TCMH1072 ITSAA732-14
TCMH569 Semen torreyae 榧子 TCMH569
TCMH1938 Quisqualis indica 使君子 TCMH1938 GENG1719-16
TCMH905 Picrorhiza kurrooa 胡黄连 TCMH905 GBVX6435-15, GBVX5995-15
TCMH1212 Melia azedarach 苦楝子 TCMH1212 ITSAN2144-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH1681 Artemisia carvifolia 青蒿 TCMH1681 KU555619
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH695 Uncaria rhynchophylla 钩藤 TCMH695 ITSAM939-14
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT661 FOLH1 Glutamate carboxypeptidase II Hydrolase Q04609
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1174 Mycobacterium bovis BCG
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1184 Mycobacterium fortuitum
TCMT1185 Mycobacterium phlei
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1193 Staphylococcus
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1200 Bacillus thuringiensis
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1216 Vibrio cholerae
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1262 Mycoplasma putrefaciens
TCMT1266 Mycobacterium abscessus
TCMT1267 Mycobacterium chelonae
TCMT1268 Nocardia farcinica
TCMT1269 Mycobacterium ulcerans
TCMT1270 Streptomyces coelicolor
TCMT1271 Shigella flexneri
TCMT1273 Pseudomonas putida
TCMT1275 Erwinia chrysanthemi
TCMT1278 Pseudomonas
TCMT1279 Staphylococcus aureus subsp. aureus
TCMT1280 Salmonella sp.
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1287 Bacillus subtilis subsp. spizizenii ATCC 6633
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1303 Bacillus
TCMT1305 Salmonella enteritidis
TCMT1311 Pseudomonas tolaasii
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1325 Mycobacterium gordonae
TCMT1326 Shigella
TCMT1328 Enterococcus avium
TCMT1329 Bacillus fortis
TCMT1330 Salmonella enterica subsp. enterica serovar Paratyphi B
TCMT1331 Acinetobacter sp.
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1461 Salmonella enterica subsp. enterica serovar Gallinarum
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.983
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MMP2, MPO, POLB, PPARA, PRKCA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 12.6892
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, HSD17B2, IDO1, IGF1R, INSR, MAOB, MMP2, MMP9, MPO, POLB, PPARA, PTGS2, RORC, SRC, TEK, TYR 12.2224
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.2224
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP12, MMP9, PDE5A, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.018
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP12, MMP9, PDE5A, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.0005
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MMP2, MMP9, MPO, POLB, PPARA, PRKCA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 11.5481
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOB, MET, POLA1, POLB, PPARA, PRKCA, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.1258
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSPA1A, IDO1, MPO, PDE5A, PIM1, PPARA, PTGS2, TBXAS1, TYR, XDH 9.07225
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, F10, FLT3, GPR35, HSPA1A, HTR6, INSR, KDR, MET, MMP12, MMP9, PDE5A, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.84795
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, IDO1, MAOB, MPO, PTGS2, RORC, SRC, TYR 8.77447
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PDE5A, PRKCA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.62228
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PDE5A, PRKCA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.46683
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD2, EGFR, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PRKCA, PTGS2, SMAD3, SRC, TEK, XDH 8.12461
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, FLT3, GPR35, HSPA1A, HTR6, INSR, KDR, MET, PDE5A, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 8.12414
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, HTR6, IDO1, INSR, KDR, MET, MMP12, MMP2, MMP9, PDE5A, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.01942
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.99606
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MPO, NUAK1, PDE5A, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 7.94203
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PDE5A, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 7.91243
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, POLB, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 7.81145
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK 7.59002
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, F10, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MMP12, MMP2, MMP9, MPO, NUAK1, POLA1, POLB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TYR 7.55262
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK 7.50121
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, POLB, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 7.37507
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK 7.35054
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MAOB, MMP9, PTGS2, SRC 7.35054
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK 7.35054
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.2723
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 7.26645
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FABP4, HSD17B2, IDO1, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, MPO, PDE5A, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TYR 7.2522
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, KDR, MAOB, POLB, SRC 7.23449
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FLT3, MAOB, PTGS2, RORC, SRC, TEK, TYR 7.21091
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA3, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, KDR, MAOB, POLB, PTGS2, SRC 7.12091
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 7.02982
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PDE5A, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.97487
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK 6.92557
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.92557
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.90415
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MAOB, MET, MMP2, MMP9, MPO, PIM1, POLB, PPARA, PRKCA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TNKS2, TYR 6.89921
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK 6.83817
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, PTGS2, TBXAS1 6.67539
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, CNR1, CNR2, CYP19A1, DRD2, DUSP3, EGFR, FABP4, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 6.54327
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK 6.40942
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CNR1, DRD1, DRD2, EGFR, HCAR2, KDR, PTGS2, SRC, TNKS, TNKS2 6.3791
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.32255
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.19804
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, EGFR, HCAR2, PTGS2, TNKS, TNKS2 6.03205
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 6.03205
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, FABP3, FLT3, IGF1R, INSR, MAOB, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 6.00178
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, EGFR, FABP4, IDO1, KDR, MET, MMP12, PPARA, PRKCA, PTGS2, PTPRS, SMAD3, TEK 5.97712
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK 5.95586
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, DRD2 5.91816
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK 5.91816
[BP] GO:0030335 positive regulation of cell migration BCL2, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK 5.90444
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, DRD1, DRD2, EGFR, GPR35, HCAR2, HSPA1A, INSR, MAOB, MMP12, MMP9, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC 5.90444
[BP] GO:2000147 positive regulation of cell motility BCL2, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK 5.72064
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 5.68544
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 5.6753
[BP] GO:0051272 positive regulation of cellular component movement BCL2, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK 5.58841
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.57701
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, MAOB, PPARA, PTGS2, SRC, TEK 5.45977
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 5.45742
[BP] GO:0040017 positive regulation of locomotion BCL2, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK 5.41673
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, MAOB, MMP9, PIM1, POLB, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TYR 5.34287
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PDE5A, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.28012
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PDE5A, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.28012
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, DRD2, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK 5.26692
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MAOB, MPO, PTGS2, SRC 5.2524
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PDE5A, PRKCA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.24225
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.24008
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, EGFR, HSPA1A, MMP2, MPO, POLB, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 5.2122
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MAOB, MPO, PTGS2, TBXAS1, TYR, XDH 5.21037
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CNR1, CNR2, CYP19A1, DRD1, DRD2, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 5.19307
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.19066
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PDE5A, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 5.13623
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, POLB, PPARA, PTGS2, SMAD3, SRC, TEK 5.07717
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, IDO1, MAOB, MPO 5.06427
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MAOB, MPO, PTGS2, SRC 5.01088
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IDO1, IGF1R, KDR, MAOB, MET, MMP12, MMP9, MPO, PDE5A, PIM1, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.99697
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB, MPO 4.98905
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TNKS 4.96199
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DRD2, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC, TNKS 4.95048
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 4.87958
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, POLB, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 4.84252
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, HTR6 4.81145
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MAOB, MET, MMP12, MMP9, MPO, PDE5A, PIM1, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.81145
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PTGS2, TBXAS1 4.79927
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, EGFR, FLT3, MET, PIM1, POLA1, SRC, TEK, TYR 4.792
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.76587
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PDE5A, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.74896
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 4.74565
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MAOB, MMP9, PTGS2 4.74459
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.72228
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1A1, CYP1A2, DRD1, DRD2, DUSP3, EGFR, F10, FLT3, FUT7, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, POLB, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 4.71663
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CNR1, CNR2, CYP19A1, DRD2, DUSP3, IDO1, MMP12, PDE5A, PTPRS 4.63639
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC 4.62917
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.61723
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, POLA1, POLB, SMAD3, SRC 4.61624
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, GPR35, MAOB, MMP9, PTGS2 4.60181
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC, TEK 4.5681
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MAOB, MPO 4.56461
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PDE5A, PPARA, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 4.55504
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PDE5A, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 4.54038
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, EGFR, PTGS2 4.5304
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.5304
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, HCAR2, HSD17B1, HSD17B2, PRKCA 4.49798
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PDE5A, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.49798
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CA3, CYP1B1, EGFR, HSPA1A, MMP9, MPO, PTGS2, SRC 4.49684
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, DRD2, EGFR, FLT3, INSR, KDR, PDE5A, PRKCA, PTPN1, SRC, TEK, XDH 4.48803
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 4.46789
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MAOB, MPO 4.41204
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DRD1, DRD2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH 4.40554
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, F10, INSR, MET, SRC, TEK, XDH 4.39699
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DRD1, DRD2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH 4.39039
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 4.38802
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DRD2, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PDE5A, PRKCA, PTPN1, SRC, TEK, XDH 4.38115
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, PTGS2 4.36065
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 4.35956
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.359
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PDE5A, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 4.30494
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 4.29608
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.29336
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD1, DRD2, EGFR, HCAR2, INSR, MMP12, PTGS2, SMAD3, SRC 4.2168
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA3, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, IDO1, MMP2, MMP9, MPO, NUAK1, POLA1, POLB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 4.2168
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, POLA1, POLB, PTGS2, PTPN1, RORC, SMAD3, SRC 4.2168
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2, TBXAS1 4.19335
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PTGS2, RORC, SMAD3, SRC 4.14986
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.14936
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, EGFR, PTGS2 4.14936
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, EGFR, PTGS2 4.14936
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 4.09206
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PDE5A, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 4.09031
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 4.08103
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, PRKCA, SRC, TEK, TNKS 4.0782
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK 4.06953
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CHRM1, CHRM2, CNR1, CYP1B1, DRD2, EGFR, GPR35, HCAR2, HSPA1A, IDO1, INSR, KDR, MET, MMP12, MMP9, PDE5A, PIM1, PRKCA, PTGS2, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH 4.03588
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.03588
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK 4.01764
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR, PTGS2 4.01313
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DRD2, DUSP3, HCAR2, HSPA1A, IDO1, MMP12, MMP2, PDE5A, PRKCA, PTPN1, PTPRS, SMAD3, SRC 3.94233
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, MAOB, TYR 3.9361
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PTGS2, SRC, TEK 3.92522
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, EGFR, HCAR2, HSPA1A, IDO1, KDR, MET, MMP12, MMP9, PDE5A, PIM1, PRKCA, PTGS2, SMAD3, SRC, TEK 3.92231
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TNKS 3.87661
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, IDO1, MAOB, MMP1, MMP12, MMP2, MMP9, MPO, PDE5A, SRC, XDH 3.84931
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MAOB, MMP12, MPO, PTGS2, SMAD3, SRC 3.83658
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.83621
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, INSR, MAOB, PTGS2, SMAD3 3.83166
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, MAOB, TYR 3.83166
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, CNR1, DRD2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.78969
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, BCL2, CA2, CA7, CHRM1, CNR1, DRD1, DRD2, GPR35, MAOB, MMP9, PTGS2 3.77352
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.77352
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.74012
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.72419
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, DRD2, EGFR, GPR35, HCAR2, PDE5A, PRKCA, PTGS2, SMAD3 3.71542
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MAOB, MMP12, MPO, PTGS2, SMAD3, SRC 3.63514
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PDE5A, PIM1, POLB, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 3.60559
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DRD2, DUSP3, EGFR, KDR, PRKCA, PTPN1, SRC, TEK 3.59989
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, DRD2, PPARA, PTPRS, SMAD3, TEK 3.54232
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, FABP4, IDO1, KDR, MET, PRKCA, PTGS2, SMAD3 3.54232
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 3.53408
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.49344
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.49249
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.49249
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CBR1, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PDE5A, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 3.48282
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CBR1, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 3.46215
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.42214
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.42005
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, MAOB, PTGS2, SRC 3.3879
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.38092
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, MAOB, PTGS2, SRC 3.38092
[BP] GO:0003018 None ADORA1, CHRM1, DRD1, EGFR, PTGS2, SRC, TEK 3.38092
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PDE5A, PPARA, PRKCA, SMAD3, SRC, TEK 3.38092
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2 3.37272
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.34225
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.33941
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PPARA, PTGS2, TBXAS1 3.30749
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CHRM4, CSNK2A1, DRD2, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.27065
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.2226
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.2226
[BP] GO:0090087 None ACHE, ADORA1, CA2, CHRM1, CNR1, DRD2, EGFR, HCAR2, MMP12, PRKCA, PTGS2, PTPN1, SMAD3, SRC 3.19635
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 3.17147
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.1233
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 3.11949
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.10229
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.10229
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.09803
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PDE5A, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.08606
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, SMAD3, TEK 3.08431
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 3.07696
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PDE5A, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH 3.07696
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 3.07195
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.06201
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PDE5A, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.03614
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DUSP3, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.03452
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, MAOB 2.98726
[BP] GO:0019371 None CBR1, PTGS2, TBXAS1 2.98559
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PDE5A, PTPN1, SRC 2.95261
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 2.95005
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, MPO, PTGS2, SRC, TYR 2.94405
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 2.94216
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HCAR2, MET, PPARA, SMAD3 2.90099
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD2, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PDE5A, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.9005
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.88307
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, IDO1, MAOB, MMP12, MPO, PTGS2, SMAD3, SRC, TYR 2.86195
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, EGFR, FLT3, PTGS2, RORC, SRC 2.86195
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4, DRD2 2.84808
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.84808
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.83885
[BP] GO:0050890 None ADORA1, CHRM1, CNR1, DRD1, DRD2, EGFR, INSR, PTGS2 2.80931
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PDE5A, PTPN1, SRC, TEK, TNKS 2.80742
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TNKS 2.80742
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, DRD2, EGFR, KDR, PRKCA, SRC, TEK 2.80484
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.79057
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 2.76958
[BP] GO:0051726 regulation of cell cycle AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, PTGS2, SMAD3, SRC, TNKS 2.71618
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, PTGS2, SRC 2.71494
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.71029
[BP] GO:0003013 None ADORA1, CHRM1, DRD1, EGFR, PTGS2, SRC, TEK 2.70757
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, INSR, PRKCA, SRC 2.70411
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PTPN1, SMAD3 2.70411
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, EGFR, PPARA, RORC, SRC 2.70411
[BP] GO:0016311 None ALPL, BCL2, CA3, CDC25B, DUSP3, POLB, PTPN1, PTPRS 2.70411
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, DRD2, EGFR, PDE5A, PTGS2 2.69787
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.69787
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.69787
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, MAOB, PTGS2 2.69787
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.69787
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, INSR, PDE5A, PTPN1, SRC, TEK, TNKS 2.6758
[BP] GO:0045776 None ADORA1, CNR1, DRD2, PPARA 2.66129
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.65799
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOB 2.62895
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOB 2.62895
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.62895
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.62895
[BP] GO:0032845 None ADORA1, BCL2, DRD2, SRC, TNKS, TNKS2 2.62497
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, DRD1, DRD2 2.61813
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PTGS2, SRC, TEK 2.60752
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, BCL2, CYP1B1, DRD2, FABP3, HSPA1A, IDO1, PDE5A, PTGS2, SMAD3, XDH 2.58257
[BP] GO:0070201 None ACHE, BCL2, CHRM1, CNR1, DRD2, EGFR, HCAR2, MMP12, PRKCA, PTGS2, PTPN1, SMAD3, SRC 2.56659
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.56386
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.56089
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.56089
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.56089
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.56089
[BP] GO:0008217 None ADORA1, CNR1, DRD2, PPARA, PTGS2, SMAD3 2.56066
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PRKCA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.55359
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, EGFR, HSD17B2, IDO1, INSR, MMP2, MMP9, PTGS2, SRC 2.54698
[BP] GO:0002695 negative regulation of leukocyte activation AXL, CNR1, CNR2, DUSP3, IDO1, PDE5A 2.53248
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.49439
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.4864
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PRKCA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.47415
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PRKCA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.47415
[BP] GO:0090257 None ADORA1, CHRM1, CHRM2, PDE5A, PRKCA, PTGS2, SMAD3 2.47278
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, MPO, PTGS2, SRC, TYR 2.46469
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PDE5A, PTPN1, SRC, TEK 2.45768
[BP] GO:0006928 movement of cell or subcellular component AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR6, KDR, MMP1, MMP12, MMP9, PRKCA, PTGS2, SRC, TEK, TUBB3 2.45225
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45013
[BP] GO:0033602 None CNR1, DRD2 2.45013
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, MPO, POLB, PTGS2 2.44787
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, POLB, PRKCA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.44711
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.44325
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.41944
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, CHRM1, DRD2, EGFR, HCAR2, MMP12, PTGS2, SMAD3, SRC 2.41595
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DRD2, DUSP3, EGFR, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.39744
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.39217
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 2.39217
[BP] GO:0051094 positive regulation of developmental process AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, IDO1, INSR, KDR, PDE5A, PIM1, PRKCA, PTGS2, SMAD3, SRC, TEK 2.39163
[BP] GO:0031349 positive regulation of defense response CNR1, EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PTGS2, SRC 2.38331
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.36909
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.36909
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.36909
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.36909
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.36909
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.36841
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.36841
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, PRKCA, SRC, TNKS 2.36221
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, EGFR, IGF1R, INSR, MMP2, MMP9, PTGS2, RORC, SRC 2.35419
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.34949
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.3408
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TEK, TYR 2.33868
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.33868
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.33013
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.31504
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.31504
[BP] GO:0007613 None CNR1, DRD1, DRD2, INSR, PTGS2 2.30394
[BP] GO:0050866 negative regulation of cell activation AXL, CNR1, CNR2, DUSP3, IDO1, PDE5A 2.30303
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, DRD2, EGFR, HSPA1A, INSR, MPO, PIM1, PTPRS, SMAD3, TNKS2 2.26996
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, AURKB, BCL2, CDC25B, DRD2, EGFR, FLT3, HSPA1A, INSR, MET, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.26996
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.26996
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, PPARA 2.26424
[BP] GO:0032880 regulation of protein localization ACHE, BCL2, CHRM1, CNR1, CSNK2A1, DRD2, EGFR, HCAR2, MMP12, PRKCA, PTGS2, PTPN1, SMAD3, SRC 2.26424
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.26424
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.26424
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.26424
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.25811
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TNKS 2.24089
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.24029
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.24029
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, PDE5A, PTPN1, SRC, TEK 2.24029
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, MMP12, SRC 2.23445
[BP] GO:0051223 None ACHE, CHRM1, CNR1, DRD2, EGFR, HCAR2, MMP12, PRKCA, PTGS2, PTPN1, SMAD3, SRC 2.22946
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, MAOB, SRC 2.21704
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.21704
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.21704
[BP] GO:0070213 None TNKS, TNKS2 2.21704
[BP] GO:0038171 None CNR1, CNR2 2.21704
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21704
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 2.2042
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PDE5A, PTPN1, SRC 2.20243
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH 2.1967
[BP] GO:0002791 None ACHE, ADORA1, CNR1, DRD2, EGFR, HCAR2, MMP12, PRKCA, SRC 2.17997
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PDE5A, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.17295
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.17295
[BP] GO:0050729 positive regulation of inflammatory response CNR1, EGFR, FABP4, IDO1, PTGS2 2.17295
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, DRD2, EGFR, HCAR2, PRKCA 2.17295
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.17295
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.17295
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.17295
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.17295
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, PDE5A, PTPN1, SRC 2.16521
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, PRKCA, SRC, TNKS 2.15766
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.15444
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, EGFR, HCAR2, MAOB, MMP12, PRKCA, SRC 2.14736
[BP] GO:0051894 None KDR, SMAD3, TEK 2.12411
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.11469
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.1144
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, SMAD3, SRC, TEK 2.1144
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, EGFR, IDO1, INSR, KDR, NUAK1, PDE5A, PIM1, PPARA, PRKCA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TNKS2, XDH 2.10873
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.08524
[BP] GO:0045932 None ADORA1, PDE5A, PTGS2 2.07979
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, NUAK1, PDE5A, PIM1, POLA1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.06445
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.06445
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, PTGS2 2.06445
[BP] GO:0051926 negative regulation of calcium ion transport BCL2, DRD2, GPR35, PTGS2 2.06445
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, PTGS2, TYR 2.06425
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, NUAK1, POLB, PRKCA, PTPN1, SRC, TEK 2.04277
[BP] GO:0021853 None DRD1, DRD2 2.04277
[BP] GO:1904936 None DRD1, DRD2 2.04277
[BP] GO:0042321 None ADORA1, DRD2 2.04277
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.04277
[BP] GO:1903393 None KDR, SMAD3, TEK 2.04277
[BP] GO:0001975 None CNR2, DRD1, DRD2 2.04277
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, MPO, PRKCA, RORC, SMAD3, SRC 2.04277
[BP] GO:0097746 None ADORA1, CHRM1, DRD1, EGFR, PTGS2 2.03948
[BP] GO:0035296 None ADORA1, CHRM1, DRD1, EGFR, PTGS2 2.03948
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PDE5A, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.03772
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.02638
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.02638
[BP] GO:0051704 multi-organism process AXL, BCL2, CHRM2, CYP1A1, EGFR, HSPA1A, IDO1, INSR, KDR, MET, MMP1, MMP12, MPO, POLA1, SMAD3, SRC 2.02638
[BP] GO:0051222 positive regulation of protein transport ACHE, CHRM1, DRD2, EGFR, HCAR2, MMP12, PTGS2, SMAD3, SRC 2.02638
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CHRM1, CNR1, CNR2, CYP1B1, DRD1, DRD2, EGFR, INSR, PDE5A, PTGS2, SRC, TEK, TYR 2.02436
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.00339
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.00339
[BP] GO:0009416 response to light stimulus AURKB, BCL2, DRD1, DRD2, EGFR, PTGS2, TYR 2.00339
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, F10, FLT3, GPR35, HTR6, IGF1R, INSR, KDR, MET, PTPRS, TEK 4.18288
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, EGFR, INSR, MET, PTGS2, SRC, TEK 4.14936
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, DUSP3, EGFR, F10, FLT3, GPR35, HTR6, IGF1R, INSR, KDR, MET, PTGS2, PTPRS, SRC, TEK 4.11276
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, DRD1, DRD2, EGFR, F10, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCA, PTPN1, PTPRS, SMAD3, SRC, TEK 3.69743
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, FLT3, GPR35, HTR6, IGF1R, INSR, KDR, MET, PTPRS, TEK 3.36125
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, F10, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR6, IGF1R, INSR, KDR, MAOB, MET, MMP2, PIM1, PRKCA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR 2.80742
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KDR, MAOB, MMP2, MMP9, MPO, PDE5A, PIM1, POLA1, PRKCA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 2.16122
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.13534
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR6, IGF1R, INSR, KDR, MAOB, MET, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TEK, TYR 2.10948
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.9917
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PDE5A, PIM1, POLA1, POLB, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 15.3609
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH 13.0303
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PDE5A, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 12.983
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 12.1894
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.1068
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 7.88575
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, F10, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PDE5A, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TNKS2, TYR, XDH 7.55551
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, PRKCA, PTPN1, RORC, SMAD3, TNKS 7.2522
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.02921
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PRKCA, SRC, TEK 6.48407
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MAOB, MPO, PTGS2, TBXAS1, TYR, XDH 6.40942
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.28963
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PDE5A, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TNKS2, TYR, XDH 6.28963
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC, TBXAS1 5.96487
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC, TBXAS1 5.72064
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 5.13335
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.84252
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, IDO1, MAOB, MPO, POLA1, PTGS2, SRC, TBXAS1, XDH 4.70882
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, TEK 4.54778
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, TEK 4.54778
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.38075
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK 4.29305
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.27226
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.18354
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 4.14936
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.03588
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.56218
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.49249
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1, TYR 3.38092
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, PRKCA, SRC, TEK 3.38092
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.38092
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.38092
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, DRD2, HTR6 3.38007
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 3.34872
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.32834
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.23657
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 3.2226
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, HTR6 3.20139
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 2.96332
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, POLA1, PRKCA, SRC, TEK, TUBB3, XDH 2.95261
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 2.92652
[MF] GO:0043168 anion binding ABCB1, ALOX15, AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MPO, NUAK1, PDE5A, PIM1, PRKCA, PTPRS, SRC, TEK, TUBB3, XDH 2.91892
[MF] GO:0016788 None ACHE, ADORA1, ALPL, CA1, CA2, CA3, CDC25B, CHRM1, DUSP3, PDE5A, POLA1, PTPN1, PTPRS 2.90099
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR6 2.80484
[MF] GO:0042578 None ADORA1, ALPL, CA3, CDC25B, CHRM1, DUSP3, PDE5A, PTPN1, PTPRS 2.73847
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 2.72935
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 2.70411
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.65799
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, POLA1, PRKCA, SRC, TEK, TUBB3, XDH 2.56683
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, POLA1, PRKCA, SRC, TEK, TUBB3, XDH 2.56659
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.56356
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.45013
[MF] GO:0004949 None CNR1, CNR2 2.45013
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.42778
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MPO, NUAK1, PDE5A, PIM1, POLA1, PRKCA, PTPRS, SRC, TEK, TUBB3 2.39933
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.36909
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTPN1, PTPRS, SRC, TEK 2.23406
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.10873
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.10407
[MF] GO:0043559 insulin binding IGF1R, INSR 2.04277


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.3031
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.4542
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.4488
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, INSR, KDR, PRKCA, TEK, DRD2, MET, EGFR, IGF1R 6.28
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6, CHRM1, CNR2, GPR35, CNR1, ADORA3, CHRM4, ADORA1, DRD1, DRD2 6.28
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOB, ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 5.0952
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, BCL2, PRKCA, PTGS2, MMP9, MET, EGFR, IGF1R 5.0038
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, BCL2, PIM1, CYP1B1, PRKCA, PTGS2, MMP9, MET, EGFR, CDC25B 5.0952
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.4429
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, KDR, BCL2, PRKCA, TEK, MET, EGFR, IGF1R 4.7731
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1, IDO1 5.0038
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, CHRM1, ADORA1, DRD1, DRD2, PPARA 4.7261
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, PRKCA, MMP9, MET, EGFR, IGF1R 4.7144
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.9952
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4, BCL2, PRKCA 4.2472
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, PRKCA, DRD1, DRD2, EGFR 4.7261
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, PRKCA, TEK, EGFR, IGF1R 4.3835
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, MAOB, ALOX5, ALOX15, PRKCA, PTGS2 4.2472
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, PTGS2 4.277
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, PRKCA, MET, EGFR, IGF1R 3.8111
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 3.5278
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1, PRKCA 3.3924
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.4156
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.2394
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, CHRM1, PRKCA, DRD1, EGFR 3.2356
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 3.7713
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2 3.2671
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, PRKCA, MMP9 2.7652
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PRKCA, PTGS2 3.1704
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA, EGFR 2.5724
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 2.9115
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, IGF1R 2.3778
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4, EGFR 2.0812
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9918
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1, PRKCA 2.161
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB, PRKCA, DRD1, DRD2 2.0692
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.0321
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, PRKCA, EGFR, CDC25B, HSPA1A 1.8529
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PRKCA, PTGS2, EGFR 1.8529
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, PDE5A 1.7768
Glioma_Homo sapiens_hsa05214 PRKCA, EGFR, IGF1R 2.0068
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.0153
Amphetamine addiction_Homo sapiens_hsa05031 MAOB, PRKCA, DRD1 1.9897
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.9382
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.9897
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.7167
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, PRKCA, EGFR 1.7357
Cocaine addiction_Homo sapiens_hsa05030 MAOB, DRD1, DRD2 2.2928
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9817
Morphine addiction_Homo sapiens_hsa05032 ADORA1, PRKCA, DRD1 1.699
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PRKCA, PTGS2 1.6135
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.6887
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.5527
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, PRKCA 1.2807
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, PRKCA, EGFR 1.2734
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.4806
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.2583
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.2983
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, PRKCA, MMP9 1.4806
Purine metabolism_Homo sapiens_hsa00230 POLA1, PDE5A, XDH 1.1249
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 1.1163
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.0028
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2735
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8105
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2729
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.8784
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9477
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8072
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7464
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCA 0.9477
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, PRKCA 0.8306
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.7652
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.769
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3286
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 0.937
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.965
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7535
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8072
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.7464
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6651
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCA, EGFR 0.934
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, PRKCA 0.7286
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7203
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3544
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3636
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9889
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7016
Pancreatic secretion_Homo sapiens_hsa04972 CA2, PRKCA 0.9539
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6379
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCA 0.3636
Influenza A_Homo sapiens_hsa05164 PRKCA, HSPA1A 0.6455
Phagosome_Homo sapiens_hsa04145 TUBB3, MPO 0.712
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 1.0088
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.0012
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.4837
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.5812
Axon guidance_Homo sapiens_hsa04360 MET 0.3786
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3867
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3923
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.3923
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA 0.4045
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.08
Gastric acid secretion_Homo sapiens_hsa04971 CA2, PRKCA 1.1163
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.431
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4303
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4385
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.1801
Amoebiasis_Homo sapiens_hsa05146 PRKCA 0.4393
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCA 0.4541
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCA 0.4437
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.452
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.1329
Circadian entrainment_Homo sapiens_hsa04713 PRKCA 0.452
Long-term depression_Homo sapiens_hsa04730 PRKCA, IGF1R 1.2337
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2583
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2 1.1502
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCA, EGFR 1.2651
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.467
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.213
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1867
Salivary secretion_Homo sapiens_hsa04970 PRKCA 0.467
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.1867
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4766
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.467
Insulin secretion_Homo sapiens_hsa04911 PRKCA 0.4752
Peroxisome_Homo sapiens_hsa04146 XDH 0.4781
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.4837
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2412
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5107
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3, PRKCA 1.2734
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.4873
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4939
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5107
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5107
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5143
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.522
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.512
Long-term potentiation_Homo sapiens_hsa04720 PRKCA 0.5302
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5302
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5324
Shigellosis_Homo sapiens_hsa05131 SRC 0.5302
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCA 0.5538
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5812
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5995
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, PRKCA 1.5171
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6036
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6036
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.6047
Malaria_Homo sapiens_hsa05144 MET 0.6092
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA, IDO1 1.5864
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6139
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA 0.6187
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6861
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6238
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6379
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, TYR 1.5864
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.699
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6394
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5699
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7042
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.6651
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7667
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8529
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7342
DNA replication_Homo sapiens_hsa03030 POLA1 0.7003
Base excision repair_Homo sapiens_hsa03410 POLB 0.7203
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7698
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7438
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7667
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.7986
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9158
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.965
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0183


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)