TCM Prescription: Fu Fang Qing Dai Pills



Prescription Description
Prescription IDTCMF3879
Pinyin NameFu Fang Qing Dai Wan
Chinese Name复方青黛丸
English NameFu Fang Qing Dai Pills
Function Description银屑病, 玫瑰糠疹, 药毒
IndicationsPsoriasis
Disease ICD-11 Category EA90 [Psoriasis, 银屑病 ];
Human Tissues Associated with IndicationSkin
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1678 Indigo naturalis 青黛 TCMH1678
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH2706 Lithospermum erythrorhizon 紫草 TCMH2706
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH112 Dictamnus albus 白藓皮 TCMH112 GBVK982-11
TCMH1055 NA 建曲 TCMH1055
TCMH719 Dryopteris crassirhizoma 贯众 TCMH719 GBVM2585-11
TCMH2134 Smilax glabra 土茯苓 TCMH2134 CPBOL4081-11
TCMH1396 Portulaca oleracea 马齿苋 TCMH1396 ITSAK4834-14
TCMH170 Dioscorea hypoglauca 萆薢 TCMH170 GBVU109-13, GBVT4961-13
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT263 SOAT2 Acyl coenzyme A:cholesterol acyltransferase 2 Transferase O75908
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT572 EPHX1 Epoxide hydrolase 1 Hydrolase P07099
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, EPHX1, EPHX2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 16.9462
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, EPHX1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TRPV1, TYR 15.4555
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, EGFR, EPHX2, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SOAT1, SOAT2, TRPV1 15.4555
[BP] GO:0065008 regulation of biological quality ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC6A2, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TRPV1, XDH 14.2192
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 13.8642
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A3, SLC6A4, SRC, TEK, TRPV1, TYR 13.8642
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, EPHX1, ESR1, ESRRA, FLT3, NR3C1, PTGS2, RORC, SLC6A3, SLC6A4, SRC, TEK, TRPV1, TYR 13.6969
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EPHX1, EPHX2, FABP3, FUT7, GLO1, HSPA1A, IDO1, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, SOAT1, SOAT2, TYR, XDH 12.7639
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TYR, XDH 12.7639
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPR35, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SOAT1, SRC, TEK, TERT, TOP2A, TRPV1, XDH 11.2811
[BP] GO:0048518 positive regulation of biological process ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SLC6A4, SMAD3, SOAT1, SRC, TEK, TERT, TOP2A, TRPV1, XDH 10.9758
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, EGFR, EPHX2, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SOAT1, SOAT2 10.8962
[BP] GO:0032501 multicellular organismal process ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESRRB, FABP4, HSD17B2, IDO1, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TRPV1, TYR 10.8962
[BP] GO:0042592 homeostatic process ADRA2A, AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3, SOAT1, SOAT2, SRC, TERT, TRPV1 10.7091
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2, SOAT1, SOAT2 10.6388
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, FABP3, FABP4, GPR35, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3, SOAT1, SOAT2, TRPV1 10.2605
[BP] GO:0042127 regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.2605
[BP] GO:0010647 positive regulation of cell communication ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 10.1907
[BP] GO:0023056 positive regulation of signaling ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 10.1579
[BP] GO:0050896 response to stimulus ACHE, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, EPHX1, EPHX2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR 10.1105
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TRPV1 9.94666
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EPHX1, EPHX2, NQO2, PTGS1, RORC 9.94121
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, NR3C1, PPARA, PTGS2, SLC6A4, SRC, TEK, TRPV1 9.94121
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TERT, TRPV1 9.87444
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGS2, SLC6A3, SRC, TERT 9.81314
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, SLC6A3, SOAT1, SOAT2, TYR 9.58755
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EPHX2, PTGS1, PTGS2 9.37023
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EPHX2, PTGS1, PTGS2 9.05551
[BP] GO:0009967 positive regulation of signal transduction ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.96383
[BP] GO:0043067 regulation of programmed cell death AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.93167
[BP] GO:0010941 regulation of cell death AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.88707
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EPHX2, PTGS1, PTGS2 8.86626
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, EPHX1, EPHX2, KDR, SLC6A3, SLC6A4, SRC 8.80815
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 8.75964
[BP] GO:1902531 regulation of intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.51936
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, DRD4, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.4952
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, IDO1, NR3C1, PTGS2, RORC, SLC6A4, SRC, TYR 8.45054
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CES1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TYR 8.42006
[BP] GO:0042981 regulation of apoptotic process AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.35359
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FABP3, KCNH2, KDR, NR3C1, PTGS2, SLC6A2, SLC6A3, SLC6A4, SRC, TRPV1 8.31011
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TRPV1 8.14629
[BP] GO:0009893 positive regulation of metabolic process ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SOAT1, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.94081
[BP] GO:0048584 positive regulation of response to stimulus ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESRRA, FABP4, FLT3, GPR35, HSPA1A, IDO1, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.94081
[BP] GO:0060548 negative regulation of cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.9385
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.86441
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SOAT1, SRC, TEK, TERT, TOP2A, XDH 7.6814
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A, TRPV1 7.6814
[BP] GO:0032879 regulation of localization ACHE, ADRA2A, ADRA2C, ALOX12, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, GPR35, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 7.67938
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HSD11B1, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TYR, XDH 7.64013
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.62526
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EPHX2, FABP3, PPARA, PTGS1, PTGS2 7.61151
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 7.40616
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EPHX2, PTGS1, PTGS2 7.39349
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, EGFR, INSR, PTGS2, SLC6A2, SLC6A3, SLC6A4, SMAD3, TRPV1 7.33523
[BP] GO:0048523 negative regulation of cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX12, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, IDO1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.30608
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A3, SLC6A4, SRC, TEK, TRPV1, TYR 7.27824
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.2378
[BP] GO:0031325 positive regulation of cellular metabolic process ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CDC25B, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.19593
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, EGFR, EPHX2, HSPA1A, IDO1, SLC6A3 7.18529
[BP] GO:0010646 regulation of cell communication ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.07705
[BP] GO:0019220 regulation of phosphate metabolic process ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD2, DRD3, DRD4, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.04077
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 7.00981
[BP] GO:0048519 negative regulation of biological process ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, IDO1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.00382
[BP] GO:0051174 regulation of phosphorus metabolic process ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD2, DRD3, DRD4, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.99028
[BP] GO:0023051 regulation of signaling ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 6.95839
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EPHX2, FABP3, GLO1, IDO1, PPARA, PTGS1, PTGS2 6.91961
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC, TOP2A 6.88162
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD2, DRD4, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.88162
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD2, DRD4, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.88162
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A3, SLC6A4, SRC, TEK, TRPV1, TYR 6.80808
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, NR3C1, PTGS2, RORC, SLC6A4, SRC, TRPV1 6.80122
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EPHX2, PTGS1, PTGS2 6.73382
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.58779
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD2, DUSP3, EGFR, EPHX2, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 6.58317
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.49723
[BP] GO:0051049 regulation of transport ACHE, ADRA2A, ADRA2C, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, DRD2, DRD3, DRD4, EGFR, GPR35, HSPA1A, INSR, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TRPV1 6.46785
[BP] GO:0030334 regulation of cell migration ADRA2A, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.45734
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGS2, SLC6A3, TERT 6.32085
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 6.31696
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.31438
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, ALOX12, APP, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, HSPA1A, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SLC6A3, SMAD3, SRC, TEK, TERT, TRPV1 6.26726
[BP] GO:0040012 regulation of locomotion ADRA2A, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD2, DRD3, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.26726
[BP] GO:0048583 regulation of response to stimulus ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, FLT3, GPR35, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A3, SMAD3, SRC, TEK, TERT, XDH 6.26726
[BP] GO:0042327 positive regulation of phosphorylation ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD2, DRD4, EGFR, ESRRB, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.26726
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 6.18572
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.18572
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.18368
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD2, DUSP3, EGFR, EPHX2, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 6.18088
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 6.14652
[BP] GO:2000145 regulation of cell motility ADRA2A, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.06682
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.99198
[BP] GO:0048585 negative regulation of response to stimulus ADRA2A, ALOX12, ALOX15, BCL2, CYP19A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SLC6A3, SMAD3, SRC, TEK, TERT, XDH 5.89941
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TRPV1 5.88187
[BP] GO:0001934 positive regulation of protein phosphorylation ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD2, DRD4, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.87408
[BP] GO:0032225 None DRD2, DRD3, DRD4, PTGS2, SLC6A4 5.86052
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, FABP3, GPR35, KCNH2, PIK3CB, SMAD3, TRPV1 5.84506
[BP] GO:0042325 regulation of phosphorylation ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD2, DRD4, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 5.81693
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRA2A, ADRA2C, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.7687
[BP] GO:0051050 positive regulation of transport ACHE, ADRA2A, APP, AXL, BCL2, CA2, CYP19A1, DRD2, DRD3, DRD4, EGFR, INSR, KCNH2, MMP12, PTGS2, SLC6A4, SMAD3, SRC, TERT, TRPV1 5.7687
[BP] GO:0043410 positive regulation of MAPK cascade ADRA2A, ADRA2C, ALOX15, APP, DRD2, DRD4, EGFR, FLT3, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 5.7687
[BP] GO:0023057 negative regulation of signaling ACHE, ADRA2A, ADRA2C, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.7487
[BP] GO:0051239 regulation of multicellular organismal process ADRA2A, ADRA2C, ALOX12, APP, AXL, BCL2, CA2, CHRM2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, GPR35, HSPA1A, IDO1, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.74714
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 5.6784
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT 5.65694
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.65109
[BP] GO:0043271 negative regulation of ion transport ADRA2A, BCL2, DRD2, DRD3, DRD4, GPR35, KCNH2, MMP9, PTGS2 5.57
[BP] GO:0051270 regulation of cellular component movement ADRA2A, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.56337
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 5.50557
[BP] GO:0009966 regulation of signal transduction ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.48942
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.46599
[BP] GO:0043408 regulation of MAPK cascade ADRA2A, ADRA2C, ALOX15, APP, DRD2, DRD4, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 5.4527
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EPHX1, EPHX2, FABP3, FABP4, FUT7, HSPA1A, IDO1, MMP1, MMP12, MMP2, MMP9, PIK3CB, SLC6A3, SRC, XDH 5.43767
[BP] GO:0080134 regulation of response to stress ADRA2A, ALOX12, APP, CYP19A1, DRD2, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.43767
[BP] GO:0006950 response to stress ACHE, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD4, EGFR, EPHX2, HSPA1A, IDO1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 5.41589
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 5.38328
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, GPR35, KCNH2, PIK3CB, SMAD3, TRPV1 5.33524
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.29497
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19, EPHX2 5.2848
[BP] GO:0051247 positive regulation of protein metabolic process ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SOAT1, SRC, TEK, XDH 5.26336
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 5.26336
[BP] GO:0001932 regulation of protein phosphorylation ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.26281
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 5.13217
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EPHX2, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR 5.12058
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, TRPV1 5.11696
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.10211
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A3, SMAD3, SRC, TEK, TYR 5.07985
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KCNH2, KDR, NR3C1, PTGS2, SRC, TRPV1 5.05634
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, DRD3, DRD4, SLC6A3, TYR 5.04244
[BP] GO:0009987 cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 5.02883
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, APP, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, NR3C1, PTGS2, SLC6A4, SMAD3, SRC, TRPV1 5.02049
[BP] GO:0010817 regulation of hormone levels ACHE, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HSD11B1, HSD17B1, HSD17B2 5.0195
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.95671
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 4.94248
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, DRD4, GPR35, KCNH2, MMP9 4.89141
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 4.88022
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.77771
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, SLC6A3, SLC6A4, TEK, TRPV1, TYR 4.77771
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, GPR35, KCNH2, PIK3CB, SMAD3, TRPV1 4.75733
[BP] GO:0030258 lipid modification ALOX12, CYP1A1, CYP3A4, EGFR, EPHX2, MET, PIK3CA, PIK3CB, SOAT1, SOAT2 4.72656
[BP] GO:0050790 regulation of catalytic activity ADRA2A, ADRA2C, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.69564
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.69066
[BP] GO:0050793 regulation of developmental process ADRA2C, ALOX12, APP, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, IDO1, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 4.68751
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.66066
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.6408
[BP] GO:0031399 regulation of protein modification process ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.64016
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TERT, TOP2A 4.60058
[BP] GO:0044092 negative regulation of molecular function ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 4.60058
[BP] GO:0065009 regulation of molecular function ADRA2A, ADRA2C, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 4.59495
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EPHX2, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR 4.59495
[BP] GO:0032844 regulation of homeostatic process ADRA2A, AURKB, BCL2, CA2, CA7, DRD2, DRD3, EGFR, KDR, PIK3CB, PTGS2, SRC, TRPV1 4.59495
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, DRD4, GPR35, KCNH2, MMP9 4.5811
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD2, DRD4, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.58094
[BP] GO:0040008 regulation of growth ALOX12, APP, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, SLC6A3, SLC6A4, SMAD3 4.58094
[BP] GO:0043549 regulation of kinase activity ADRA2A, ADRA2C, APP, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.5767
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A 4.53672
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EPHX2, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR 4.50326
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PTGS2, RORC, SMAD3, SOAT1, SRC, TERT, TOP2A, TRPV1 4.49756
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR, TERT 4.49363
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTGS2, SLC6A3, SLC6A4, TEK, TRPV1, TYR 4.44981
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.44861
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 4.42898
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, DRD4, GPR35, KCNH2, MMP9 4.42898
[BP] GO:0097176 epoxide metabolic process ALOX12, EPHX1, EPHX2 4.42898
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.42898
[BP] GO:0031401 positive regulation of protein modification process ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD2, DRD4, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.40095
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, EPHX2 4.37556
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, GPR35, PIK3CB, SMAD3, TRPV1 4.37375
[BP] GO:0032101 regulation of response to external stimulus ALOX12, CYP19A1, DRD2, DRD3, EGFR, ESR1, FABP4, IDO1, KDR, MET, MMP12, PPARA, PTGS2, SLC6A3, SMAD3, TEK 4.34953
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 4.33847
[BP] GO:0019222 regulation of metabolic process ACHE, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SLC6A4, SMAD3, SOAT1, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.32688
[BP] GO:0045859 regulation of protein kinase activity ADRA2A, ADRA2C, APP, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 4.31345
[BP] GO:0051926 negative regulation of calcium ion transport ADRA2A, BCL2, DRD2, DRD4, GPR35, PTGS2 4.30866
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 4.28656
[BP] GO:0003018 None ADRA2A, ADRA2C, EGFR, EPHX2, PTGS2, SLC6A4, SRC, TEK 4.28358
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, IDO1, INSR, MMP2, MMP9, PTGS2, SLC6A4, SRC, TOP2A 4.26504
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EGFR 4.25536
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.24127
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, PIK3CA, SLC6A3 4.24126
[BP] GO:0044093 positive regulation of molecular function ADRA2A, ADRA2C, APP, AURKB, BCL2, CDC25B, DRD2, DRD4, EGFR, ESR1, ESR2, FLT3, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.23745
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.23745
[BP] GO:0051338 regulation of transferase activity ADRA2A, ADRA2C, APP, AURKB, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.23745
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 4.197
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.18496
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, SLC6A3, TYR 4.15864
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FLT3, FUT7, GLO1, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.15006
[BP] GO:0019216 regulation of lipid metabolic process ADRA2A, CYP1A1, DRD3, EPHX2, FABP3, FLT3, PPARA, PTGS2, RORC, SRC, TEK 4.14484
[BP] GO:0003008 None ADRA2A, ADRA2C, AKR1B1, APP, BCL2, CYP1B1, DRD2, DRD3, EGFR, EPHX2, INSR, KCNH2, PIK3CA, PTGS2, SLC6A3, SLC6A4, SOAT2, SRC, TEK, TRPV1, TYR 4.1349
[BP] GO:0080090 regulation of primary metabolic process ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SOAT1, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.13001
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.11005
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PTGS2, RORC, SMAD3, SOAT1, SRC, TERT, TOP2A, TRPV1 4.10532
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SOAT1, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.10532
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.10348
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.08035
[BP] GO:0007610 None APP, BCL2, DRD2, DRD3, DRD4, EGFR, IDO1, INSR, PPARA, PTGS2, SLC6A3, SLC6A4, TRPV1 4.06772
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH 4.04655
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, APP, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 4.03737
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, TRPV1 4.03173
[BP] GO:0055065 metal ion homeostasis APP, BCL2, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, GPR35, KCNH2, PIK3CB, SMAD3, TRPV1 4.03173
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, CA2, CA7, DRD2, DRD3, DRD4, EGFR, PTGS2, SLC6A4 4.02111
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, CA2, CA7, DRD2, DRD3, DRD4, EGFR, PTGS2, SLC6A4 4.02111
[BP] GO:0033674 positive regulation of kinase activity ADRA2A, ADRA2C, CDC25B, DRD2, DRD4, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.01551
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 4.01551
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 4.01551
[BP] GO:0032413 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 4.00775
[BP] GO:0043085 positive regulation of catalytic activity ADRA2A, ADRA2C, APP, AURKB, BCL2, CDC25B, DRD2, DRD4, EGFR, ESR1, FLT3, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.00151
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, PIK3CB, SMAD3, TRPV1 3.98451
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.97858
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.97643
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 3.97533
[BP] GO:0009892 negative regulation of metabolic process ADRA2A, APEX1, APP, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 3.97126
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, DRD2, DRD4, EGFR, PTGS2 3.96764
[BP] GO:0001775 cell activation ADRA2A, ADRA2C, ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC, TRPV1 3.96328
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, PIK3CA, PIK3CB, SMAD3, TRPV1 3.93484
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 3.93107
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 3.93107
[BP] GO:0009611 response to wounding ACHE, ALOX15, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 3.89851
[BP] GO:0032147 activation of protein kinase activity ADRA2A, ADRA2C, DRD2, DRD4, EGFR, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.88548
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EGFR 3.88542
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, PIK3CB, SMAD3, TRPV1 3.88183
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, PIK3CB, SMAD3, TRPV1 3.87929
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.86844
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC, TRPV1 3.8654
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, DRD3, DRD4, SLC6A3 3.8654
[BP] GO:0051934 None SLC6A2, SLC6A3, SLC6A4 3.8654
[BP] GO:0090494 None SLC6A2, SLC6A3, SLC6A4 3.8654
[BP] GO:0090493 None SLC6A2, SLC6A3, SLC6A4 3.8654
[BP] GO:0051583 None SLC6A2, SLC6A3, SLC6A4 3.8654
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.8654
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP3A4 3.8654
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, PIK3CB, SMAD3, TRPV1 3.84435
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 3.84435
[BP] GO:0032410 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 3.79625
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, PIK3CB, SMAD3, TRPV1 3.78779
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.76711
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, PIK3CA, PIK3CB, SMAD3, TRPV1 3.73498
[BP] GO:0051051 negative regulation of transport ADRA2A, ADRA2C, APP, BCL2, DRD2, DRD3, DRD4, GPR35, HSPA1A, KCNH2, MMP9, PTGS2 3.73408
[BP] GO:0051347 positive regulation of transferase activity ADRA2A, ADRA2C, AURKB, CDC25B, DRD2, DRD4, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.73408
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SOAT1, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.73408
[BP] GO:0031347 regulation of defense response CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.73408
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.67955
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CDC25B, CES1, CYP1A1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PTGS2, RORC, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A 3.66336
[BP] GO:0098810 None SLC6A2, SLC6A3, SLC6A4 3.6472
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SOAT1, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.64618
[BP] GO:0051172 None ADRA2A, APEX1, APP, AURKB, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 3.63824
[BP] GO:0051094 positive regulation of developmental process ADRA2C, ALOX12, APP, AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, IDO1, INSR, KDR, PIM1, PTGS2, SLC6A3, SMAD3, SRC, TEK, TERT 3.63123
[BP] GO:0043405 regulation of MAP kinase activity ADRA2A, DRD4, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC 3.62748
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH 3.61732
[BP] GO:0045860 positive regulation of protein kinase activity ADRA2A, ADRA2C, CDC25B, DRD2, DRD4, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.5964
[BP] GO:0043269 regulation of ion transport ADRA2A, APP, BCL2, CA2, CA7, DRD2, DRD3, DRD4, GPR35, KCNH2, MMP9, PTGS2, SLC6A4 3.59265
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, RORC, SMAD3, SOAT1, SRC, TERT, TOP2A 3.57685
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.57685
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC, TRPV1 3.57685
[BP] GO:0065007 biological regulation ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPR35, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.57098
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.56396
[BP] GO:0003013 None ADRA2A, ADRA2C, EGFR, EPHX2, PTGS2, SLC6A4, SRC, TEK 3.52836
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.52836
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR, TERT 3.52836
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 3.52836
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.49694
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.49694
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD2, DRD3, KDR, SRC, TRPV1 3.48901
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, IDO1, PTGS1, PTGS2 3.4867
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.48004
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.48004
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.47713
[BP] GO:0008217 None DRD2, DRD3, EPHX2, PPARA, PTGS1, PTGS2, SMAD3 3.45913
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, ALOX12, AOX1, APEX1, APP, BCL2, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, NR3C1, PPARA, PTGS2, RORC, SLC6A3, SMAD3, SOAT1, SOAT2, TERT, TOP2A, TYR, XDH 3.45148
[BP] GO:0042752 None DRD2, DRD3, DRD4, PPARA, RORC, TOP2A 3.43418
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.40454
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 3.35684
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, NR3C1, PTGS2, SRC 3.35271
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, NR3C1, PTGS2, SRC 3.34155
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.31931
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.31928
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.30822
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 3.29701
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.27617
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS1, PTGS2 3.26384
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, EGFR, PIK3CB, PTGS2 3.2568
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.24459
[BP] GO:0022898 None ADRA2A, APP, BCL2, DRD2, DRD3, DRD4, GPR35, MMP9 3.23137
[BP] GO:2000026 regulation of multicellular organismal development ADRA2C, ALOX12, APP, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, IDO1, INSR, KDR, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.21752
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.21558
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.18476
[BP] GO:0030168 platelet activation ADRA2A, ADRA2C, AXL, PIK3CA, PIK3CB, SRC 3.17344
[BP] GO:0045744 None ADRA2A, DRD2, DRD3, MET 3.15695
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2, SLC6A3 3.15695
[BP] GO:0048638 regulation of developmental growth APP, BCL2, DRD2, DRD3, INSR, PIK3CA, PIM1, SLC6A3, SLC6A4 3.13538
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, PIK3CB, SMAD3, TRPV1 3.12519
[BP] GO:0051704 multi-organism process ADRA2C, APP, AXL, BCL2, CHRM2, CYP1A1, DRD3, DRD4, EGFR, HSPA1A, IDO1, INSR, KDR, MET, MMP1, MMP12, SLC6A4, SMAD3, SRC 3.12519
[BP] GO:0042632 None EPHX2, FABP3, FABP4, SOAT1, SOAT2 3.12519
[BP] GO:0055092 None EPHX2, FABP3, FABP4, SOAT1, SOAT2 3.12519
[BP] GO:0007194 None ADRA2A, DRD2, DRD3, DRD4 3.10765
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 3.09544
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.09437
[BP] GO:0035556 intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AXL, BCL2, CYP1B1, DRD2, DRD3, EGFR, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.08565
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.06693
[BP] GO:0032409 None ADRA2A, APP, BCL2, DRD2, DRD3, DRD4, GPR35, MMP9 3.06693
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.06693
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, APP, BCL2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, MMP12, PTGS2, PTPN1, SMAD3, SRC, TERT 3.06359
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.06359
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 3.0577
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EPHX1, EPHX2, FABP3, FABP4, HSPA1A, IDO1, PIK3CB, SLC6A3, SRC, XDH 3.0577
[BP] GO:0009894 regulation of catabolic process ADRA2A, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 3.0523
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, IDO1 3.04874
[BP] GO:0032268 regulation of cellular protein metabolic process ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.04874
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 3.04038
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.04038
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, ALOX12, DRD2, MET, PIK3CA, TRPV1 3.03056
[BP] GO:0032148 None ADRA2A, ADRA2C, INSR, SRC 3.02554
[BP] GO:0031280 None ADRA2A, DRD2, DRD3, DRD4 3.02554
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PTGS2, SRC 3.0155
[BP] GO:0090087 None ACHE, ADRA2A, ADRA2C, APP, CA2, DRD2, DRD3, DRD4, EGFR, MMP12, PTGS2, PTPN1, SMAD3, SRC 3.00628
[BP] GO:1900543 None ADRA2A, DRD2, DRD3, DRD4, PPARA 2.99942
[BP] GO:0010628 positive regulation of gene expression APP, DRD2, DRD3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, NR3C1, PIK3CB, PPARA, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A 2.99332
[BP] GO:0045980 None ADRA2A, DRD2, DRD3, DRD4, PPARA 2.97413
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.97413
[BP] GO:0015872 None SLC6A2, SLC6A3, SLC6A4 2.9716
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2C19, CYP3A4 2.9716
[BP] GO:0045934 None ADRA2A, APEX1, AURKB, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TRPV1 2.96997
[BP] GO:0009115 None AOX1, XDH 2.96051
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.96051
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.96051
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.96051
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, APP, BCL2, DRD2, DRD3, DRD4, EGFR, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.95636
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 2.95531
[BP] GO:0051350 None ADRA2A, DRD2, DRD3, DRD4 2.94971
[BP] GO:0045927 positive regulation of growth ALOX12, BCL2, CSNK2A1, DRD2, EGFR, INSR, PIM1, SLC6A3 2.94711
[BP] GO:0097746 None ADRA2A, ADRA2C, EGFR, EPHX2, PTGS2, SLC6A4 2.94166
[BP] GO:0035296 None ADRA2A, ADRA2C, EGFR, EPHX2, PTGS2, SLC6A4 2.94166
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2, SLC6A4 2.94166
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, TERT 2.9405
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.93395
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.925
[BP] GO:0044057 None ADRA2A, ADRA2C, CHRM2, DRD2, DRD3, EGFR, GPR35, KCNH2, PTGS2, SMAD3, TRPV1 2.9155
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.91197
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 2.90428
[BP] GO:0007193 None ADRA2A, CHRM2, DRD2, DRD3, DRD4 2.8904
[BP] GO:0051952 None ADRA2A, ADRA2C, DRD2, DRD3, DRD4 2.8904
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.88964
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 2.88964
[BP] GO:0033604 None ADRA2A, ADRA2C, DRD2 2.88964
[BP] GO:0016125 None APP, CES1, CYP19A1, CYP1B1, SOAT1, SOAT2 2.87691
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 2.87691
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT 2.87513
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.86748
[BP] GO:0043406 positive regulation of MAP kinase activity ADRA2A, DRD4, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC 2.86094
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.84434
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, PTGS2, SLC6A4, TRPV1, TYR 2.84434
[BP] GO:1901020 None ADRA2A, DRD2, DRD4, GPR35 2.83489
[BP] GO:0034762 None ADRA2A, APP, BCL2, CA2, DRD2, DRD3, DRD4, GPR35, KCNH2, MMP9 2.81393
[BP] GO:0051246 regulation of protein metabolic process ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SOAT1, SRC, TEK, XDH 2.81146
[BP] GO:0050880 None ADRA2A, ADRA2C, EGFR, EPHX2, PTGS2, SLC6A4 2.81146
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.80089
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.80089
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.80089
[BP] GO:0051254 None APP, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 2.80089
[BP] GO:0035150 None ADRA2A, ADRA2C, EGFR, EPHX2, PTGS2, SLC6A4 2.7979
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, EGFR, KDR, SRC, TEK 2.79723
[BP] GO:0007165 signal transduction ADRA2A, ADRA2C, AKR1B1, APP, AXL, BCL2, CA1, CA2, CHRM2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 2.79462
[BP] GO:0051241 negative regulation of multicellular organismal process ADRA2C, ALOX12, APP, AXL, BCL2, DRD2, DRD3, EGFR, GPR35, IDO1, PTGS2, SLC6A4, SMAD3, TEK, TERT, XDH 2.76782
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.75523
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.75523
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, PPARA, RORC, SLC6A4 2.74923
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CES1, CYP1B1, CYP3A4, SOAT1, SOAT2 2.74135
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 2.72011
[BP] GO:0051937 None SLC6A2, SLC6A3, SLC6A4 2.71731
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, SMAD3, SRC, TEK, TOP2A 2.71731
[BP] GO:0032102 negative regulation of response to external stimulus ALOX12, CYP19A1, DRD2, DRD3, PPARA, SLC6A3, SMAD3, TEK 2.7129
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.7129
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.71237
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP3A4, EPHX2, HSPA1A, IDO1, SLC6A3, XDH 2.71101
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, NR3C1, PTGS2 2.70559
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.70244
[BP] GO:1903170 None ADRA2A, DRD2, DRD4, GPR35 2.69081
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.69081
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.68762
[BP] GO:0042058 None ADRA2A, ADRA2C, APP, EGFR, MMP9 2.6716
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD2, DRD3, EGFR, PTGS2, TYR 2.658
[BP] GO:0030818 None ADRA2A, DRD2, DRD3, DRD4 2.65652
[BP] GO:0002682 regulation of immune system process ALOX15, APP, AXL, BCL2, CA2, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, HSPA1A, IDO1, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 2.64838
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.64838
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.64838
[BP] GO:0070920 None EGFR, ESR1, TERT 2.64838
[BP] GO:0018904 None ALOX12, EPHX1, EPHX2 2.64838
[BP] GO:1904062 None ADRA2A, APP, DRD2, DRD3, DRD4, GPR35, KCNH2, MMP9 2.64489
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 2.63782
[BP] GO:0045761 None ADRA2A, DRD2, DRD3, DRD4 2.62585
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, APP, DRD2, DRD3, DRD4, EGFR, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.61841
[BP] GO:0009410 None DRD2, DRD3, DRD4, EGFR, NR3C1, SLC6A3 2.60477
[BP] GO:0042136 neurotransmitter biosynthetic process ACHE, CYP1B1, SLC6A3, SLC6A4 2.59147
[BP] GO:0030803 None ADRA2A, DRD2, DRD3, DRD4 2.59147
[BP] GO:0045893 None APP, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 2.58489
[BP] GO:1903508 None APP, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 2.58489
[BP] GO:1902680 None APP, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 2.5818
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX12, ALOX15, CYP1A1, IDO1, PTGS1, PTGS2 2.57731
[BP] GO:1901386 None DRD2, DRD4, GPR35 2.57731
[BP] GO:0001504 None SLC6A2, SLC6A3, SLC6A4 2.57731
[BP] GO:0051047 None ACHE, CYP19A1, DRD2, DRD3, EGFR, MMP12, SLC6A4, SRC, TRPV1 2.57731
[BP] GO:0034435 None SOAT1, SOAT2 2.57731
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.57731
[BP] GO:0051944 None DRD2, DRD4 2.57731
[BP] GO:0034433 None SOAT1, SOAT2 2.57731
[BP] GO:0034434 None SOAT1, SOAT2 2.57731
[BP] GO:0046110 None AOX1, XDH 2.57731
[BP] GO:0060160 None DRD2, DRD3 2.57731
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57731
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.57731
[BP] GO:0051586 None DRD2, DRD4 2.57731
[BP] GO:0050433 None ADRA2A, ADRA2C, DRD2, DRD3 2.57545
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, DRD2, PIK3CB, PTPN1, SRC 2.56229
[BP] GO:0030815 None ADRA2A, DRD2, DRD3, DRD4 2.54088
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK 2.53339
[BP] GO:0032412 None ADRA2A, APP, DRD2, DRD3, DRD4, GPR35, MMP9 2.52769
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, KCNH2, PPARA, SLC6A2, SLC6A3, SLC6A4, TRPV1 2.50968
[BP] GO:1900372 None ADRA2A, DRD2, DRD3, DRD4 2.50966
[BP] GO:0030809 None ADRA2A, DRD2, DRD3, DRD4 2.50966
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, KDR, PTGS2, TEK, TERT 2.50571
[BP] GO:0051591 None APEX1, APP, SLC6A3, TEK, TYR 2.48706
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.48706
[BP] GO:0001819 positive regulation of cytokine production ADRA2A, CYP1B1, DRD2, HSPA1A, IDO1, MMP12, PTGS2, SMAD3, SRC 2.48078
[BP] GO:0030800 None ADRA2A, DRD2, DRD3, DRD4 2.47917
[BP] GO:0007188 None ADRA2A, ADRA2C, CHRM2, DRD2, DRD3, DRD4 2.47888
[BP] GO:0008285 negative regulation of cell proliferation APP, BCL2, CYP1B1, DRD2, FABP3, HSPA1A, IDO1, PTGS2, SLC6A4, SMAD3, TERT, XDH 2.46812
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.45468
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.4508
[BP] GO:2001258 None DRD2, DRD4, GPR35, MMP9 2.44937
[BP] GO:0050730 None ADRA2A, ADRA2C, APP, EGFR, FLT3, PTPN1, SRC 2.43263
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, PTGS2, SLC6A3, TERT 2.43263
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.43263
[BP] GO:1901184 None ADRA2A, ADRA2C, APP, EGFR, MMP9 2.43263
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.42025
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.40808
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADRA2A, DRD4, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.40377
[BP] GO:1900542 None ADRA2A, DRD2, DRD3, DRD4, ESRRB, INSR, PPARA 2.40212
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.40109
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.40109
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.40109
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.40109
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.40109
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.40109
[BP] GO:0071880 None ADRA2A, ADRA2C, DRD2 2.40109
[BP] GO:0007611 None APP, DRD2, DRD3, EGFR, INSR, PTGS2, SLC6A4 2.39904
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.39904
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.38647
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.37269
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.37269
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD4, IDO1, SLC6A2 2.37269
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.37269
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.34512
[BP] GO:0015844 None SLC6A2, SLC6A3, SLC6A4 2.34512
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.34456
[BP] GO:0006140 None ADRA2A, DRD2, DRD3, DRD4, ESRRB, INSR, PPARA 2.3409
[BP] GO:0098657 import into cell ACHE, ALOX15, APP, AXL, DRD2, DRD3, SLC6A2, SLC6A3, SLC6A4, TRPV1 2.33287
[BP] GO:0051046 None ACHE, ADRA2A, ADRA2C, CYP19A1, DRD2, DRD3, DRD4, EGFR, MMP12, SLC6A4, SRC, TRPV1 2.32633
[BP] GO:0035625 None ADRA2A, ADRA2C 2.32633
[BP] GO:0032811 None ADRA2A, ADRA2C 2.32633
[BP] GO:0006145 None AOX1, XDH 2.32633
[BP] GO:0051582 None DRD2, DRD4 2.32633
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32633
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.32397
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.32391
[BP] GO:0031348 negative regulation of defense response CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 2.29871
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.29834
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.29834
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.29834
[BP] GO:0050708 None ACHE, ADRA2A, ADRA2C, DRD2, DRD3, DRD4, EGFR, MMP12, SRC 2.29232
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 2.28475
[BP] GO:0055088 None EPHX2, FABP3, FABP4, SOAT1, SOAT2 2.25573
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, MET, PIK3CA, PIK3CB 2.25366
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, KDR, PTGS2, TEK, TERT 2.25219
[BP] GO:0006928 movement of cell or subcellular component ADRA2A, ALOX12, APP, AXL, CYP1B1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK 2.24957
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.24957
[BP] GO:0051953 None ADRA2A, ADRA2C, DRD2 2.24957
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.24957
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.24957
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.24957
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.24957
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MMP9, NUAK1, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1 2.23712
[BP] GO:0019229 None ADRA2A, ADRA2C, EGFR, PTGS2 2.22494
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.22089
[BP] GO:0007626 None APP, DRD2, DRD3, DRD4, IDO1, SLC6A3 2.20875
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.20875
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 2.20875
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, APEX1, EGFR, ESR1, FLT3, INSR, NR3C1, SRC 2.20506
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.20399
[BP] GO:0031279 None ADRA2A, DRD2, DRD3, DRD4 2.20399
[BP] GO:0051894 None KDR, SMAD3, TEK 2.20399
[BP] GO:0061900 None APP, EGFR, TRPV1 2.20399
[BP] GO:0071875 None ADRA2A, ADRA2C, DRD2 2.20399
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.20399
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2C19, CYP3A4, SLC6A3 2.20135
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, TERT, XDH 2.19841
[BP] GO:0060341 regulation of cellular localization ADRA2A, APP, BCL2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, PTGS2, PTPN1, SMAD3, SRC, TERT 2.19253
[BP] GO:1902652 None APP, CES1, CYP3A4, SOAT1, SOAT2 2.1879
[BP] GO:0043086 negative regulation of catalytic activity ADRA2A, APP, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, FABP4, IGF1R, MMP9, PTGS2, PTPN1, SRC 2.18577
[BP] GO:0051253 None APEX1, AURKB, DRD3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TRPV1 2.18543
[BP] GO:0051339 None ADRA2A, DRD2, DRD3, DRD4 2.18543
[BP] GO:0007187 None ADRA2A, ADRA2C, CHRM2, DRD2, DRD3, DRD4 2.17204
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.17204
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, HSPA1A, INSR, KDR, PIK3CB, PPARA, PTPN1 2.16603
[BP] GO:0009895 negative regulation of catabolic process ADRA2A, BCL2, EGFR, MET, PIK3CA, PPARA, SMAD3 2.15386
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADRA2A, DRD4, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC 2.1534
[BP] GO:0045595 regulation of cell differentiation ADRA2C, APP, AXL, BCL2, CA2, DRD2, DRD3, EGFR, ESRRA, ESRRB, KDR, PPARA, PTGS2, RORC, SLC6A4, SMAD3, TERT, TRPV1, XDH 2.15237
[BP] GO:0035624 None ADRA2A, ADRA2C 2.15237
[BP] GO:0090325 None DRD2, DRD3 2.15237
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.15237
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.15237
[BP] GO:0014060 None ADRA2A, ADRA2C 2.15237
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.14935
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, DRD2, PTGS2, SLC6A4 2.14712
[BP] GO:0008150 biological_process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.14712
[BP] GO:0046394 None ALOX12, ALOX15, ALOX5, CYP1A1, IDO1, PTGS1, PTGS2 2.13819
[BP] GO:0045596 None APP, BCL2, DRD3, EGFR, ESRRB, PPARA, SLC6A4, SMAD3, TERT, TRPV1, XDH 2.13819
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.13819
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, DRD2, DUSP3, ESR1, HSPA1A, IDO1, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 2.13819
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.13657
[BP] GO:0010959 None ADRA2A, BCL2, DRD2, DRD3, DRD4, GPR35, KCNH2, PTGS2 2.13657
[BP] GO:0002791 None ACHE, ADRA2A, ADRA2C, DRD2, DRD3, DRD4, EGFR, MMP12, SRC 2.13504
[BP] GO:0016053 None ALOX12, ALOX15, ALOX5, CYP1A1, IDO1, PTGS1, PTGS2 2.13467
[BP] GO:0006869 None DRD2, DRD3, DRD4, FABP3, PPARA, SOAT1, SOAT2 2.13467
[BP] GO:0071396 cellular response to lipid AXL, EGFR, ESR1, FLT3, NR3C1, RORC, SLC6A4, SRC 2.13467
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.13467
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.13467
[BP] GO:1903393 None KDR, SMAD3, TEK 2.13467
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.13467
[BP] GO:0006693 None CES2, PTGS1, PTGS2 2.13467
[BP] GO:0006692 None CES2, PTGS1, PTGS2 2.13467
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.13467
[BP] GO:0006940 None ADRA2A, ADRA2C, CHRM2, PTGS2 2.13467
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.13394
[BP] GO:0031329 regulation of cellular catabolic process ADRA2A, APEX1, BCL2, ESRRB, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1 2.12727
[BP] GO:0000122 None AURKB, DRD3, ESR1, ESR2, ESRRA, HSPA1A, MMP12, NR3C1, PPARA, RORC, SMAD3, TRPV1 2.12286
[BP] GO:0050794 regulation of cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPR35, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SLC6A4, SMAD3, SOAT1, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.11981
[BP] GO:0010675 None ESRRB, INSR, PPARA, RORC, SRC 2.11981
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.11431
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.11431
[BP] GO:0006357 None APP, AURKB, CA9, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, GLO1, HSPA1A, MET, MMP12, NR3C1, PPARA, RORC, SMAD3, TERT, TOP2A, TRPV1 2.1111
[BP] GO:0050890 None APP, DRD2, DRD3, EGFR, INSR, PTGS2, SLC6A4 2.09724
[BP] GO:0007166 cell surface receptor signaling pathway APP, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TRPV1 2.09429
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.09364
[BP] GO:0051705 None APP, DRD3, DRD4, SLC6A4 2.09364
[BP] GO:0009888 tissue development ALOX15, ALPL, CYP1B1, INSR, KDR, PIK3CA, PPARA, PTGS2, RORC, SMAD3 2.08996
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.0732
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.07141
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.07141
[BP] GO:1903530 regulation of secretion by cell ACHE, ADRA2A, ADRA2C, CYP19A1, DRD2, DRD3, DRD4, EGFR, MMP12, SLC6A4, SRC 2.06143
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.05568
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.05229
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 2.03931
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, BCL2, CA2, CA9, CYP1B1, DRD2, EGFR, ESR1, INSR, MET, MMP2, SLC6A4, SMAD3, SRC, TEK 2.0385
[BP] GO:1903507 None APEX1, AURKB, DRD3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TRPV1 2.02869
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.02869
[BP] GO:1902679 None APEX1, AURKB, DRD3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TRPV1 2.02269
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.02266
[BP] GO:0046113 None AOX1, XDH 2.02266
[BP] GO:1990535 None APP, INSR 2.02266
[BP] GO:0032415 None DRD3, DRD4 2.02266
[BP] GO:0021984 None DRD2, SLC6A3 2.02266
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.02266
[BP] GO:0071715 None DRD2, DRD3, DRD4 2.02266
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.02266
[BP] GO:0051590 None DRD2, DRD4, SLC6A4 2.02266
[BP] GO:0007176 None ADRA2A, ADRA2C, APP 2.02266
[BP] GO:1901571 None DRD2, DRD3, DRD4 2.02266
[BP] GO:0015850 None SLC6A2, SLC6A3, SLC6A4, SOAT1, SOAT2 2.01956
[BP] GO:0016311 None ALPL, APEX1, BCL2, CDC25B, DUSP3, EPHX2, PTPN1 2.00899
[BP] GO:1903522 None ADRA2A, ADRA2C, CHRM2, DRD2, EGFR, KCNH2, PTGS2 2.00101
[CC] GO:0044444 cytoplasmic part ACHE, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KCNH2, KDR, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TERT, TOP2A, TRPV1, TYR, XDH 5.0063
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A3, SLC6A4, SRC, TEK 4.10502
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A3, SLC6A4, SRC, TEK 4.08176
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EGFR, EPHX1, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1, SOAT1, SOAT2 4.02824
[CC] GO:0005886 plasma membrane ACHE, ADRA2A, ADRA2C, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, GLO1, GPR35, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 4.02111
[CC] GO:0016020 membrane ACHE, ADRA2A, ADRA2C, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, EGFR, EPHX1, ESR1, FLT3, FUT7, GLO1, GPR35, HSD11B1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TRPV1, TYR 3.88183
[CC] GO:0098589 membrane region APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A3, SLC6A4, SRC, TEK 3.49432
[CC] GO:0031226 intrinsic component of plasma membrane ADRA2A, ADRA2C, APP, AXL, CA4, CHRM2, DRD2, DRD3, DRD4, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A3, SLC6A4, TEK, TRPV1 3.31295
[CC] GO:0044425 membrane part ACHE, ADRA2A, ADRA2C, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, ESR1, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A3, SLC6A4, SOAT1, SOAT2, SRC, TEK, TRPV1, TYR 3.29701
[CC] GO:0044459 plasma membrane part ADRA2A, ADRA2C, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM2, DRD2, DRD3, DRD4, DUSP3, EGFR, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PTGS2, SLC6A2, SLC6A3, SLC6A4, SRC, TEK, TRPV1 3.08157
[CC] GO:0005887 integral component of plasma membrane ADRA2A, ADRA2C, APP, AXL, CHRM2, DRD2, DRD3, DRD4, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A3, SLC6A4, TEK, TRPV1 3.05354
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EGFR, EPHX1, HSD11B1, HSD17B2, PTGS1, PTGS2, SOAT1, SOAT2 3.03577
[CC] GO:0005783 None APEX1, APP, BCL2, CA4, CES1, CES2, CYP19A1, FLT3, HSPA1A, KDR, PTGS2, PTPN1, SOAT1, SOAT2, XDH 2.94201
[CC] GO:0044464 cell part ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.71038
[CC] GO:0043227 membrane-bounded organelle ACHE, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SOAT1, SOAT2, SRC, TERT, TOP2A, TYR, XDH 2.3787
[CC] GO:0098793 None ADRA2C, APP, CHRM2, DRD2, SLC6A3, SLC6A4 2.35535
[CC] GO:0009986 cell surface ACHE, APP, AXL, CA4, EGFR, KCNH2, MET, SLC6A2, SLC6A3, TEK 2.19606
[CC] GO:0016323 basolateral plasma membrane ADRA2A, CA2, CA4, CA9, EGFR, TEK 2.14712
[CC] GO:0044424 intracellular part ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.11013
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.02266
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 17.0508
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 16.9462
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DUSP3, EGFR, EPHX1, EPHX2, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TYR, XDH 12.7639
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, EPHX2, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 11.6788
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.82452
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A3, SLC6A4, SRC, TEK, TOP2A, TRPV1 9.76615
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EPHX2, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 9.58755
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HSD11B1, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TYR, XDH 9.17848
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, RORC, SOAT1, SOAT2 8.51936
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1, RORC, SMAD3 7.61151
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, XDH 7.27149
[MF] GO:1901338 None ADRA2A, ADRA2C, DRD2, DRD3, DRD4, SLC6A3 7.07705
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, IDO1, PTGS1, PTGS2, SRC 7.00981
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, AOX1, APP, BCL2, CSNK2A1, DRD2, DRD4, EGFR, EPHX2, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 7.00981
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.99028
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HSD17B1, IDO1, NQO2, PTGS1, PTGS2, SOAT1, SOAT2, SRC, XDH 6.88162
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, IDO1, PTGS1, PTGS2, SRC 6.76111
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.39312
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.24533
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.97252
[MF] GO:0038023 signaling receptor activity ADRA2A, ADRA2C, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 5.88413
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.78352
[MF] GO:0097159 organic cyclic compound binding ADRA2A, ADRA2C, AOX1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TRPV1, XDH 5.67034
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, PTGS1, PTGS2, TYR 5.26281
[MF] GO:0016803 ether hydrolase activity ALOX12, ALOX15, EPHX1, EPHX2 5.13217
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 5.11285
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.10211
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, SOAT1, SOAT2, TRPV1 5.07069
[MF] GO:0004872 receptor activity ADRA2A, ADRA2C, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 5.0195
[MF] GO:0044877 macromolecular complex binding ACHE, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A3, SLC6A4, SMAD3, SRC 4.97185
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.92847
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.92847
[MF] GO:0005330 None SLC6A2, SLC6A3, SLC6A4 4.92394
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, ADRA2C, AOX1, BCL2, DRD2, EPHX2, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 4.92172
[MF] GO:0032403 protein complex binding ACHE, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A3, SLC6A4, SMAD3, SRC 4.92172
[MF] GO:0004871 signal transducer activity ADRA2A, ADRA2C, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, PPARA, RORC, SMAD3, TEK, TRPV1 4.87732
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.87436
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 4.87436
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2, NR3C1 4.83208
[MF] GO:0060089 molecular transducer activity ADRA2A, ADRA2C, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 4.8043
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.79771
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 4.79685
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.77771
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.72595
[MF] GO:0016801 None ALOX12, ALOX15, EPHX1, EPHX2 4.65162
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.58094
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, TYR 4.56034
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.5266
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.34416
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 4.23745
[MF] GO:0019899 enzyme binding ADRA2A, APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, HSPA1A, KCNH2, MET, NR3C1, PPARA, PTGS2, PTPN1, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TOP2A 4.1349
[MF] GO:0070405 ammonium ion binding ACHE, DRD2, DRD3, DRD4, SLC6A3, SLC6A4 4.05709
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.93107
[MF] GO:0005329 None SLC6A2, SLC6A3, SLC6A4 3.8654
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT 3.70021
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, HSD17B2, XDH 3.67955
[MF] GO:0046983 protein dimerization activity ACHE, ADRA2A, ADRA2C, AOX1, AXL, BCL2, DRD2, EGFR, EPHX2, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 3.65573
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, IDO1, PTGS1, PTGS2 3.61732
[MF] GO:0051379 None ADRA2A, ADRA2C, DRD4 3.48004
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.48004
[MF] GO:0008504 None SLC6A2, SLC6A3, SLC6A4 3.31958
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.31958
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.31958
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SLC6A3, SMAD3 3.21467
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP3A4 3.02554
[MF] GO:0043168 anion binding ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SOAT1, SOAT2, SRC, TEK, TOP2A, TRPV1, XDH 2.9764
[MF] GO:0004952 None DRD2, DRD3, DRD4 2.9716
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.96051
[MF] GO:0034736 None SOAT1, SOAT2 2.96051
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.96051
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.96051
[MF] GO:0004772 None SOAT1, SOAT2 2.96051
[MF] GO:0036094 small molecule binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SOAT1, SOAT2, SRC, TEK, TOP2A, TRPV1, XDH 2.86748
[MF] GO:1901363 heterocyclic compound binding AOX1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.67433
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.65652
[MF] GO:0004935 None ADRA2A, ADRA2C, DRD2 2.64838
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.57731
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.57731
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.57731
[MF] GO:0004938 None ADRA2A, ADRA2C 2.57731
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.57731
[MF] GO:0047374 None CES1, CES2 2.57731
[MF] GO:0005328 None SLC6A2, SLC6A3, SLC6A4 2.40109
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.40109
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TRPV1 2.39531
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.32633
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.32633
[MF] GO:0051425 None APP, INSR 2.32633
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.32633
[MF] GO:0008227 None ADRA2A, ADRA2C, CHRM2, DRD2 2.29834
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TRPV1 2.29052
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TRPV1 2.256
[MF] GO:0099600 transmembrane receptor activity ADRA2A, ADRA2C, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 2.23958
[MF] GO:0004888 transmembrane signaling receptor activity ADRA2A, ADRA2C, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 2.23958
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TRPV1, XDH 2.18905
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TRPV1, XDH 2.1879
[MF] GO:0005102 receptor binding ADRA2A, ADRA2C, APP, DRD2, DRD3, EGFR, EPHX2, ESR1, ESR2, FLT3, HSPA1A, IGF1R, INSR, KDR, PTPN1, SLC6A3, SMAD3, SRC 2.18543
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.16128
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, NR3C1, PTPN1, SMAD3, SRC, TOP2A 2.15237
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.15237
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.15237
[MF] GO:0043559 insulin binding IGF1R, INSR 2.15237
[MF] GO:0051380 None ADRA2A, DRD4 2.15237
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, MET, PTPN1, SLC6A3 2.15108
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.13819
[MF] GO:0003674 molecular_function ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.13819
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.11431
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.09364
[MF] GO:0051721 None BCL2, PTPN1, SLC6A3 2.05229
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.05019
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, NR3C1, PTPN1, SMAD3, SRC, TOP2A 2.02575
[MF] GO:0004936 None ADRA2A, ADRA2C 2.02266
[MF] GO:0055131 None HSPA1A, KCNH2 2.02266
[MF] GO:0004064 arylesterase activity CA1, CA2 2.02266
[MF] GO:0043546 None AOX1, XDH 2.02266
[MF] GO:0004301 None EPHX1, EPHX2 2.02266
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.02266
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.02266
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.00531


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.1426
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.1426
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.6801
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.0511
Metabolic pathways_Homo sapiens_hsa01100 EPHX2, ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP2C19, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1, CES1 7.1869
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.4022
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 6.4153
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, EPHX2, ALOX15, ALOX12, PTGS2, CYP2C19, PTGS1 6.683
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, DRD2, MET, EGFR, IGF1R 6.3044
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, EPHX1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4, CYP2C19 7.1869
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 5.6755
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, ALOX12, PTGS2, CYP2C19, PTGS1, SLC6A4 6.3044
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PIK3CB, PTGS2, PTGS1 5.6755
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 5.3839
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 4.6375
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, EPHX1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.0564
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.5819
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.3641
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GPR35, TRPV1, NR3C1, ADRA2C, DRD2, DRD3, DRD4, ADRA2A 4.5275
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.3078
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.3236
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.0564
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0278
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.3078
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.2393
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.631
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.0496
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.8345
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.0351
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.1575
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.631
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 3.4571
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.1994
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 3.2373
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.2626
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.1465
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.266
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.8533
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.6828
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.6828
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.133
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.1703
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, INSR, PIK3CB, ADRA2C, ADRA2A 2.5926
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.1172
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.7135
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.7238
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5685
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8668
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.6203
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.133
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH, CES2, CES1 3.6084
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.3974
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4, CYP2C19 3.0619
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.2928
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, PIK3CA, PIK3CB, DRD2, PPARA 2.3074
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.3
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0619
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.3074
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB, EGFR 2.2104
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.2819
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3074
Dopaminergic synapse_Homo sapiens_hsa04728 DRD2, DRD3, SLC6A3, DRD4 2.2104
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.2629
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.1473
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.172
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.1226
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.0872
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.0283
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.794
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2523
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2638
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2747
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3497
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.3796
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB 1.338
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3388
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3188
Axon guidance_Homo sapiens_hsa04360 MET 0.3533
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.361
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5408
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8147
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.336
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.7172
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, BCL2, PIK3CB 1.5408
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.0391
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6774
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.1863
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.6955
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6482
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.6482
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, EGFR 0.6482
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.1195
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4246
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4246
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.7804
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7852
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.7953
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4246
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4347
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4338
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8077
Gap junction_Homo sapiens_hsa04540 SRC, DRD2, EGFR 1.8496
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.7994
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.838
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7804
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4561
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4561
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.0589
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4669
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9496
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.3638
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4548
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9602
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1473
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.9859
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.2994
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.997
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.033
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0492
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4955
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5092
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5071
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5217
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1226
Bile secretion_Homo sapiens_hsa04976 CA2, EPHX1, CYP3A4 2.0872
Amphetamine addiction_Homo sapiens_hsa05031 SLC6A3 0.5351
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.1044
Shigellosis_Homo sapiens_hsa05131 SRC 0.5433
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.1923
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.4498
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5706
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2399
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.21
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6007
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.6828
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3269
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2715
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6267
Malaria_Homo sapiens_hsa05144 MET 0.6392
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.336
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6482
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6442
Cocaine addiction_Homo sapiens_hsa05030 DRD2, SLC6A3 1.4594
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5246
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6966
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7467
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7467
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8139
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7804
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7637
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7953
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8133
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8222
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7852
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7091
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8139
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7744
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6955
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0238
Steroid biosynthesis_Homo sapiens_hsa00100 SOAT1, SOAT2 2.1161
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0492
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3497
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.133


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)