TCM Prescription: Du Sheng Huo Xue Tablets



Prescription Description
Prescription IDTCMF3735
Pinyin NameDu Sheng Huo Xue Pian
Chinese Name独圣活血片
English NameDu Sheng Huo Xue Tablets
Function Description跌打损伤, 痛经
IndicationsDysmenorrhea disorder, Dysmenorrhea
Disease ICD-11 Category SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ];
GA34.3 [Dysmenorrhoea, 痛经 ];
Human Tissues Associated with IndicationSkeletalMuscle
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.766
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.766
[BP] GO:0007187 None ADORA1, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 12.1454
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.7781
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 11.2552
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 11.1601
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, GBA2, HTR2B, HTR2C, PIK3CA, PPARA, PTGS1, PTGS2, TYR, XDH 10.9379
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9178
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, F3, FABP3, FABP4, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TNKS, TNKS2, XDH 10.901
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 10.6158
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, MMP2, MMP9, PIK3CA, PPARA, PTGS2, TYR 9.88547
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD2, HTR1B 9.50988
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 9.31882
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.27313
[BP] GO:0007188 None ADORA1, ADRA1A, CNR1, DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 9.16806
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP2, MMP9, PIK3CA, PPARA, PTGS2, TYR 9.05512
[BP] GO:0050795 None ADORA1, CNR1, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 8.68727
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CDK6, CNR1, DRD1, DRD2, DRD3, HCAR2, HTR2A, HTR2B, HTR2C, PIK3CB, PTGS2, TNKS, TNKS2 8.68374
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, CA2, CNR1, CNR2, DRD1, DRD2, DRD3, ESR1, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SIGMAR1 8.25533
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C 8.25533
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 8.09092
[BP] GO:0042310 None ADRA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 8.09092
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.98316
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, HTR1B, HTR5A, MMP2, PIK3CA, PPARA, PTGS2, TYR 7.91141
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGS2, TYR 7.84244
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, HSD11B2, HTR1B, HTR5A, PTGS2, TYR 7.8002
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, PTGS2 7.70759
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 7.63828
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.63828
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.63828
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 7.62003
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.38394
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.35932
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR1B, HTR2A, PTGS2 7.2539
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.24899
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, HTR1B, HTR2A, PTGS2 7.24562
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, HTR1B, HTR2A, PTGS2 7.24562
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.15079
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.10954
[BP] GO:0006690 icosanoid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.01057
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.78169
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, FABP3, FABP4, FUT7, GBA2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.71041
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7 6.66068
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, GBA2, HTR1A, TYR 6.66068
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 6.61264
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, CNR1, DRD1, DRD2, DRD3, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 6.41287
[BP] GO:0099536 None CNR1, DRD1, DRD2, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.26468
[BP] GO:0099537 None CNR1, DRD1, DRD2, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.26468
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.11628
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, HTR1B, HTR2A, PTGS2 6.06713
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALPL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, MMP1, MMP2, MMP9, PIK3CA, PPARA, PTGS2, TNKS2, TYR 6.02581
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, DRD3, HTR1B, HTR2A, MMP9, PTGS2 5.9599
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2 5.93045
[BP] GO:0008217 None ADORA1, ADRA1A, CNR1, DRD2, DRD3, HSD11B2, PPARA, PTGS1, PTGS2 5.76395
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.73601
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.73601
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.73601
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, HTR1A, HTR1B, HTR2A, HTR2B, MMP2, MMP9, PTGS1, PTGS2, XDH 5.72095
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR2C 5.69189
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 5.64223
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.43614
[BP] GO:0007267 None ADORA1, ADRA1A, CNR1, DRD1, DRD2, DRD3, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.38908
[BP] GO:0007268 None DRD1, DRD2, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.38134
[BP] GO:0098916 None DRD1, DRD2, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.38134
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 5.37501
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, DRD3, HTR1B, HTR2A 5.37501
[BP] GO:0006631 fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 5.33371
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR 5.30834
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.30505
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 5.26553
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.24857
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.24239
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 5.18949
[BP] GO:0007154 None ADORA1, ADRA1A, BCL2, CNR1, DRD1, DRD2, DRD3, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 5.16121
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, HSD11B2, HTR1B, HTR5A, MMP2, PPARA, PTGS2 5.15712
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA6, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, TYR 5.118
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 5.07513
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 5.02745
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C 5.02745
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, TNKS, TNKS2, XDH 5.01711
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1B, HTR1D 5.01511
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, BCL2, CA1, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTPN1, SIGMAR1, TNKS, TNKS2 4.89807
[BP] GO:0002031 None DRD2, DRD3, HTR1B, HTR2B 4.89407
[BP] GO:0023052 None ADORA1, ADRA1A, CNR1, DRD1, DRD2, DRD3, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.87723
[BP] GO:0014059 None CNR1, DRD2, DRD3, HTR1B, HTR2A 4.87723
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, HTR2C, TNKS, TNKS2 4.77453
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, DRD3, ESRRA, F3, FABP4, HTR2A, HTR2B, HTR2C, HTR6, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, TNKS2, XDH 4.73261
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, XDH 4.6749
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3 4.65535
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.62186
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, XDH 4.62186
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, DRD3, FABP3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 4.54732
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, BCL2, CYP1B1, DRD2, F3, HTR2A, HTR2B, HTR2C, HTR6, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 4.50641
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 4.49054
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 4.49054
[BP] GO:0090066 None ADORA1, ADRA1A, ALOX15, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.4891
[BP] GO:0051967 None ADORA1, DRD2, HTR1B, HTR2A 4.4664
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.45588
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.43992
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2, TYR 4.38339
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, ESR1, F3, HTR1A, HTR1B, HTR2A, HTR2B, MMP2, MMP9, PTGS2 4.37089
[BP] GO:0050801 ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 4.34039
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, NQO2, PTGS1 4.31039
[BP] GO:0032787 None ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PPARA, PTGS1, PTGS2 4.28633
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 4.25412
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.24582
[BP] GO:0032225 None DRD1, DRD2, DRD3, PTGS2 4.24582
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, HTR2C, PPARA 4.16026
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, PTGS2 4.16026
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 4.08742
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.08742
[BP] GO:0045776 None ADORA1, CNR1, DRD2, DRD3, PPARA 4.05828
[BP] GO:0014821 None DRD1, DRD2, HTR1D, HTR2B 4.04823
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CNR1, DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 4.04371
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SIGMAR1, TNKS2, TYR 4.0139
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, TNKS, TNKS2, XDH 4.0139
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 3.90542
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 3.90456
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.87008
[BP] GO:0050433 None CNR1, DRD2, DRD3, HTR1B, HTR2A 3.83847
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.8226
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.80617
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD2, ESRRB, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 3.80573
[BP] GO:0007610 None BCL2, CNR1, DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 3.80573
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PPARA, PTGS2, PTPN1 3.80157
[BP] GO:2001023 None CNR1, DRD1, DRD2, DRD3, HTR1B, HTR2A 3.76694
[BP] GO:0051588 None DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR2C 3.74491
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 3.74437
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PTGS2, TYR 3.74397
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, BCL2, CA2, CA7, CNR1, CYP19A1, DRD1, DRD2, DRD3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PPARA, PTGS2, PTPN1 3.68955
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, MMP9, PTGS2 3.65307
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 3.62584
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.61555
[BP] GO:0030003 cellular cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.61482
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2 3.59943
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.58387
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.55576
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR1B, HTR2B 3.54262
[BP] GO:0006873 cellular ion homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.5171
[BP] GO:0001975 None CNR2, DRD1, DRD2, DRD3 3.44977
[BP] GO:0055074 calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.44735
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.43815
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.43815
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, F3, FABP4, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, TNKS, TNKS2, XDH 3.42083
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.41452
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.41205
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD2, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 3.40497
[BP] GO:1900542 None DRD1, DRD2, DRD3, ESRRB, HTR1B, HTR1E, HTR2A, PPARA 3.38107
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, XDH 3.34586
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGS2 3.32348
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 3.3017
[BP] GO:0006140 None DRD1, DRD2, DRD3, ESRRB, HTR1B, HTR1E, HTR2A, PPARA 3.29526
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.25792
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B, HTR2C 3.25792
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, PIK3CB, XDH 3.25628
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.24964
[BP] GO:0035265 organ growth ADRA1A, BCL2, CYP19A1, ESR1 3.23946
[BP] GO:0002209 None BCL2, DRD1, HTR1A, HTR2C 3.23946
[BP] GO:0001662 None BCL2, DRD1, HTR1A, HTR2C 3.23946
[BP] GO:0055080 cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.22078
[BP] GO:0042220 None CNR1, DRD2, DRD3, HTR1B 3.19276
[BP] GO:0045777 None ADORA1, ADRA1A, CNR1, HSD11B2 3.19276
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.19276
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, PIK3CA, PIK3CB 3.19276
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, DRD3, PIK3CA, TNKS2 3.18373
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, PPARA 3.18115
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, HTR5A, MMP9, PIK3CA, PPARA, PTGS2, SIGMAR1, TYR 3.17464
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.17042
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, PIK3CA 3.16181
[BP] GO:0042596 None BCL2, DRD1, HTR1A, HTR2C 3.14786
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, DRD3, FABP3, HSD11B2, HTR1B, MMP2, PPARA, PTGS2, TYR 3.12555
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2 3.11235
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.10072
[BP] GO:1900543 None DRD2, DRD3, HTR1B, HTR1E, PPARA 3.08059
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 3.0734
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, DRD2, HCAR2, HTR1A, HTR2A, HTR2C 3.07329
[BP] GO:0045980 None DRD2, DRD3, HTR1B, HTR1E, PPARA 3.05629
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2 3.02932
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.02081
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.99777
[BP] GO:0019725 cellular homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.99035
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.96503
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALDH2, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FUT7, GBA2, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SIGMAR1, TNKS, TNKS2, TYR, XDH 2.95588
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.95555
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B, HTR2C 2.95555
[BP] GO:0048513 animal organ development ACHE, ADRA1A, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, PIK3CA, PPARA, TYR 2.94756
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C 2.91799
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, ESR1, ESR2, MMP9, PPARA, PTGS2, PTPN1, XDH 2.9019
[BP] GO:0014075 None CNR2, DRD1, DRD2, DRD3 2.88398
[BP] GO:0007208 None HTR2A, HTR2C 2.8811
[BP] GO:0009115 None AOX1, XDH 2.8811
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, HTR2A, HTR2B, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, TNKS, XDH 2.8736
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.86219
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.86219
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.86219
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, DRD3, FABP3, HSD11B2, HTR1B, MMP2, PPARA, PTGS2, TYR 2.82893
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, TNKS, TNKS2, XDH 2.81007
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2 2.80658
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.78689
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, FABP4, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.76867
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.76867
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, DRD3, HTR1B 2.70877
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.70444
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.70444
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, HTR2A, HTR2B, HTR2C 2.70444
[BP] GO:0060359 None CNR1, DRD1, DRD2, DRD3, HTR1B 2.69278
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.68436
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.68436
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C 2.65028
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PPARA, PTGS1, PTGS2, TYR 2.64645
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C 2.63798
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C 2.63798
[BP] GO:0097366 None CNR2, DRD1, DRD2, DRD3 2.63798
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.63501
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, DRD2, HTR2A, HTR2B, HTR2C, PIK3CB, PTPN1, XDH 2.61921
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, TNKS, TNKS2, XDH 2.59455
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, BCL2, CNR2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR1B, HTR2A, MMP9, PTGS2, PTPN1, XDH 2.59034
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, TNKS, TNKS2, XDH 2.57707
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, BCL2, CNR2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR1B, HTR2A, MMP9, PTGS2, PTPN1, XDH 2.57707
[BP] GO:0043112 None ACHE, DRD2, DRD3, HTR1B, HTR2B 2.55414
[BP] GO:0030815 None DRD2, DRD3, HTR1B, HTR1E 2.53834
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.50418
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, HTR1D, MMP9, PTGS2 2.50247
[BP] GO:0044092 negative regulation of molecular function ADORA3, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, MMP9, PPARA, PTGS2, PTPN1, TNKS 2.49003
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.47681
[BP] GO:0030800 None DRD2, DRD3, HTR1B, HTR1E 2.47681
[BP] GO:0046110 None AOX1, XDH 2.47416
[BP] GO:0060160 None DRD2, DRD3 2.47416
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47416
[BP] GO:0033602 None CNR1, DRD2 2.47416
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.47416
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.46947
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.42299
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, HCAR2, HTR2B, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SIGMAR1, XDH 2.42299
[BP] GO:0055065 metal ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.41809
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, PPARA, PTGS2 2.41809
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.40963
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C 2.40963
[BP] GO:0007613 None CNR1, DRD1, DRD2, HTR2A, PTGS2 2.37811
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.3723
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, HTR2C 2.36898
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, HCAR2, HTR2B, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SIGMAR1, XDH 2.35625
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.35001
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD2, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.34884
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.34884
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A, PTGS2 2.34615
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, HCAR2, HTR2B, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SIGMAR1, XDH 2.31253
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.29262
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, HTR2C 2.29157
[BP] GO:0072347 None CNR1, DRD2, DRD3, HTR1B 2.29157
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD2, ESR1, F3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, XDH 2.27926
[BP] GO:0043436 oxoacid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PPARA, PTGS1, PTGS2, TYR 2.27296
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HCAR2, HTR2B, PIK3CA, PPARA 2.27296
[BP] GO:0051282 None DRD1, DRD2, HTR2A, HTR2B, HTR2C 2.24981
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.24209
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.24209
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.24209
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2A6, CYP2D6 2.23835
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.23835
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, TNKS, TNKS2, XDH 2.22715
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.22715
[BP] GO:0070213 None TNKS, TNKS2 2.22715
[BP] GO:0006145 None AOX1, XDH 2.22715
[BP] GO:0038171 None CNR1, CNR2 2.22715
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22715
[BP] GO:0014827 None HTR1D, HTR2B 2.22715
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, TNKS, TNKS2, XDH 2.22715
[BP] GO:0006082 organic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PPARA, PTGS1, PTGS2, TYR 2.21719
[BP] GO:0030814 None DRD1, DRD2, DRD3, HTR1B, HTR1E 2.21719
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, TNKS, TNKS2, XDH 2.21719
[BP] GO:0050890 None ADORA1, CNR1, DRD1, DRD2, DRD3, HTR2A, PTGS2 2.20758
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.20758
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.20758
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.20758
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20758
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, DRD2, HTR2A, HTR2B, HTR2C, PTPN1 2.19322
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.18477
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.15709
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.15709
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.15709
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, DRD2, DRD3, PPARA 2.15067
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.13707
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, DRD2, HTR2A, HTR2B, HTR2C 2.10823
[BP] GO:0048511 rhythmic process BCL2, CSNK2A1, DRD2, DRD3, ESR1, HTR7, PPARA 2.10658
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, PTGS2 2.10033
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C 2.09959
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.08637
[BP] GO:0051051 negative regulation of transport ADORA1, BCL2, CNR1, DRD2, DRD3, HTR1B, HTR2A, MMP9, PTGS2 2.06936
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.06804
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PTGS2 2.06712
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.04834
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HSD11B2, HTR1A, HTR2C, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1 2.04834
[BP] GO:0021853 None DRD1, DRD2 2.04834
[BP] GO:0043696 None CDK6, ESRRB 2.04834
[BP] GO:0043697 None CDK6, ESRRB 2.04834
[BP] GO:0090325 None DRD2, DRD3 2.04834
[BP] GO:0071502 None HTR1B, HTR2B 2.04834
[BP] GO:1904936 None DRD1, DRD2 2.04834
[BP] GO:0042321 None ADORA1, DRD2 2.04834
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.02321
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, CA4, CNR1, CNR2, DRD1, DRD2, DRD3, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, SIGMAR1 5.24239
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, F3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SIGMAR1, TYR 5.16279
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, F3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SIGMAR1, TNKS, TNKS2, TYR 4.95811
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, SIGMAR1 4.30103
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, SIGMAR1 4.17584
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F3, GBA2, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PTPN1 3.48385
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ALOX15, CA2, CA4, CA9, CNR1, CNR2, DRD1, DRD2, DRD3, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTGS2, SIGMAR1 3.23946
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1, SIGMAR1 3.08431
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALDH2, ALOX15, AOX1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR4, HTR5A, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SIGMAR1, TNKS, TNKS2, TYR, XDH 2.49219
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.766
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.766
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.766
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.6285
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.6285
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.9713
[MF] GO:0046914 transition metal ion binding ALOX15, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, TNKS, TYR, XDH 15.502
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 14.5423
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.4441
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.8836
[MF] GO:0043169 cation binding ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, PPARA, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 11.6677
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.0935
[MF] GO:0043167 ion binding ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 10.9178
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9178
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.56503
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 9.49383
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, SIGMAR1 9.25623
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, CDK6, CNR1, CNR2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, SIGMAR1 8.57934
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.39682
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, SIGMAR1 8.1715
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, SIGMAR1 8.14244
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, TNKS 7.87162
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, SIGMAR1 7.30428
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 7.00525
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TYR 6.78169
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, XDH 6.76554
[MF] GO:0005506 iron ion binding ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 6.66579
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, F3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, SIGMAR1 6.34674
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, F3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, SIGMAR1 6.34674
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.28344
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.13359
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.02678
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 6.02581
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 5.85524
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.33058
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.94964
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.47336
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 4.45588
[MF] GO:0008144 drug binding ACHE, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, HTR1B, HTR2A, HTR2B, HTR2C, NQO2, PIK3CA, PIK3CB, PPARA, SIGMAR1 4.16026
[MF] GO:0046872 metal ion binding ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PPARA, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 4.0502
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 3.97125
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.83847
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.76694
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.76694
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.41205
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.40153
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.28562
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.14457
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.94756
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.8811
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.8811
[MF] GO:0003845 None HSD11B1, HSD11B2 2.8811
[MF] GO:0008389 None CYP2A13, CYP2A6 2.8811
[MF] GO:0071886 None HTR2A, HTR2C 2.8811
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.86219
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.47416
[MF] GO:0004949 None CNR1, CNR2 2.47416
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.35001
[MF] GO:0008289 lipid binding ALOX15, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 2.34499
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.22715
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04834


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, CYP2D6 16.9735
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, ADRA1A, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1, DRD1, DRD2, DRD3 16.5874
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.994
cAMP signaling pathway_Homo sapiens_hsa04024 HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, HTR4, HCAR2, HTR6, PIK3CA, ADORA1, DRD1, DRD2, PPARA 10.6602
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.813
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, DRD1, HTR5A, HTR4, ADRA1A 6.2774
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.5216
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1 6.2234
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALDH2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.7445
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 6.2774
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.9666
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, MMP2, PIK3CB, MMP9, ESR1, ESR2 4.631
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1 5.2692
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIK3CB, F3 3.4431
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, HTR2B, HTR2C, PIK3CB, HTR2A 3.4812
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.7016
Gap junction_Homo sapiens_hsa04540 HTR2B, HTR2C, HTR2A, DRD1, DRD2 3.6811
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9 3.0443
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, CYP1B1, PTGS2, MMP9, CDC25B 3.0443
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.1096
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, BCL2, PIK3CB, MMP9 2.8465
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.0663
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, PIK3CB, ESR1, ESR2 2.9901
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1 3.0443
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.7854
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB, ADRA1A 2.64
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0443
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.4073
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 2.3331
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4089
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.4105
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3331
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.1728
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB, ADRA1A 2.0691
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, AOX1, PIK3CB 1.9948
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.2703
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, PIK3CB, PTGS2 2.187
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.64
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB 2.1487
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.5907
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.2162
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.6934
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.187
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB 1.8274
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.1397
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB 2.0683
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.0433
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, CNR1, PIK3CB, DRD2 1.643
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B 1.7447
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX15, PTGS2, PTGS1 2.187
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.7865
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB 1.7007
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, PIK3CB, ESR1 1.5768
Platelet activation_Homo sapiens_hsa04611 PIK3CA, PIK3CB, PTGS1 1.5516
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.564
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, BCL2, PIK3CB 1.5768
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.7147
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, ADRA1A 1.5394
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.5084
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.4921
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4559
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.4582
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.3923
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB 1.4514
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, PIK3CB, PTGS2 1.3533
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, BCL2, PIK3CB 1.1417
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2051
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, PIK3CB 1.1312
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, BCL2, PIK3CB 1.1382
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2988
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2921
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.2976
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3084
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.2981
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, PIK3CB 1.0561
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.3653
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3611
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.5342
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, PIK3CB 0.6236
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.716
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8539
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.412
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.7279
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8837
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8752
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB 0.8824
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PIK3CB 0.6931
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.8489
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9219
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0885
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB 1.0849
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1008
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.0561
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0318
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4699
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4694
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, PIK3CB 1.1312
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0561
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0617
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.0422
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4824
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0422
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4816
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.0561
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.495
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4961
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.497
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2406
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.497
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, PIK3CB 1.1978
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2872
Peroxisome_Homo sapiens_hsa04146 XDH 0.5166
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, PIK3CB 1.2939
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2577
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.2347
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB 1.3007
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5318
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3562
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5519
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5501
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB 1.3202
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5615
Bile secretion_Homo sapiens_hsa04976 CA2 0.5592
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5637
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5715
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, PIK3CB 1.3923
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5825
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5715
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4514
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5134
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.4921
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4812
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.4921
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6564
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5084
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6607
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.6651
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6861
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.766
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6861
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6745
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7865
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.7018
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7272
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.7293
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9598
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8292
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.8292
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8489
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8748
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8671
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8671
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.8921
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1983
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.004
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.071
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3533


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)