TCM Prescription: Feng Re Qing Oral Liquid



Prescription Description
Prescription IDTCMF369
Pinyin NameFeng Re Qing Kou Fu Ye 
Chinese Name风热清口服液
English NameFeng Re Qing Oral Liquid
Function Description感冒, 急性上呼吸道感染
IndicationsCommon cold disorder, Common cold, Upper respiratory infection(uri)
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
Human Tissues Associated with IndicationLung, Bronchus, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1847 Lonicerae flos 山银花 TCMH1847
TCMH2328 Conyza blinii 熊胆粉 TCMH2328
TCMH1678 Indigo naturalis 青黛 TCMH1678
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH706 Trichosanthes kirilowii 瓜蒌皮 TCMH706 ITSAO4359-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 8.86671
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, PTGS2, SRC, TYR 8.60921
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.05326
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PTGS2 8.05326
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, PTGS2, SRC, TYR 7.61427
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, XDH 7.45865
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.81425
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.80342
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, PTGS2, SRC, TYR 6.69816
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.27969
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 6.27629
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.86531
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.85665
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, PTGS2, SRC, TNKS, TNKS2, XDH 5.78898
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 5.74076
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 5.73576
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, PTGS2, SRC, TYR 5.73576
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, IDO1, PIM1, PTGS2, TYR, XDH 5.67446
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.67446
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.66628
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 5.57853
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 5.55386
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 5.5163
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 5.32751
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.29916
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, SRC, TYR 5.27134
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 5.22509
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 5.19187
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 5.14334
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, SRC, TYR 5.13865
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, TNKS2, TYR 5.06016
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PTGS2, SRC, TNKS2, TYR 5.05807
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.0375
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.99404
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PTGS2, SRC 4.93521
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, IDO1, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.87897
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 4.81714
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PTGS2, SRC 4.65454
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.65454
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC 4.5712
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, KDR, PTGS2, SRC, TNKS, TNKS2 4.5712
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.52382
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PTGS2, SRC, TYR 4.50749
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.50173
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.31476
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, F3, FLT3, FUT7, GBA2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 4.11575
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.11176
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.01177
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.97984
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, SRC 3.96274
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.82775
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, MMP2, MMP9, PTGS2, SRC 3.76822
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.76822
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.75913
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.64871
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PTGS2, SRC 3.64871
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.64871
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.64685
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.517
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.51672
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.5103
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.46151
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.46103
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TYR 3.37957
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MET, PTGS2 3.33449
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, F3, FLT3, KDR, MET, PTGS2, PTPN1, SRC, XDH 3.27999
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.2293
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, PTGS2, SRC 3.2293
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS2 3.2063
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS 3.19842
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 3.11552
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, PTGS2, SRC 2.99046
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, PTGS2, SRC 2.95858
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.95072
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PTGS2, SRC 2.92847
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.90699
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.90699
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.90605
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 2.87269
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.85796
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.83788
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC 2.83788
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.83788
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CYP19A1, ESR1, F3, FABP4, IDO1, IGF1R, MET, MMP12, MMP2, PTGS2, PTPN1, SRC, XDH 2.83788
[BP] GO:0009115 None AOX1, XDH 2.83788
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.77975
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.77661
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC 2.77661
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, SRC 2.77661
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.77534
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.76815
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.73642
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.73642
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.71386
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.71155
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 2.70916
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.70502
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.70446
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.68997
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.68997
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, PTGS2, SRC 2.68688
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.68688
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.68464
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TNKS2, XDH 2.67851
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.67272
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, PTPN1, SRC 2.66417
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.66417
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC 2.66417
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.66417
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.65658
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2 2.64144
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, IDO1, XDH 2.64144
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC 2.64144
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.63011
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.59947
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.58779
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.56483
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.51257
[BP] GO:0046110 None AOX1, XDH 2.5032
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.5032
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.5032
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.49443
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.48497
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HSD11B2, PTGS2, SRC, TYR 2.48004
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.46703
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.4588
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.4588
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.4291
[BP] GO:0030335 positive regulation of cell migration BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.42229
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.40887
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.40887
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.40887
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.40577
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.38762
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35659
[BP] GO:2000147 positive regulation of cell motility BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.33034
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, PTGS2, TNKS, TNKS2 2.31882
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PTGS2, SRC 2.31397
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.30933
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.30595
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.30229
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.2981
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.2981
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.2981
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.2981
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, PTGS2 2.2981
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, MMP9, PTGS2, SRC 2.28163
[BP] GO:0051272 positive regulation of cellular component movement BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.28163
[BP] GO:0070213 None TNKS, TNKS2 2.28163
[BP] GO:0006145 None AOX1, XDH 2.28163
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28163
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.25181
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2 2.24432
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.24432
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.24432
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, PTGS2 2.24432
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC 2.23952
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 2.23904
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, MET, MMP2, MMP9, PTGS2, SRC 2.23282
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, ESR1, F3, FABP4, IDO1, KDR, MET, MMP12, PTGS2 2.22872
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, IDO1, MMP12, MMP2, PTGS2, PTPN1, SRC 2.21697
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.21697
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.21697
[BP] GO:0040017 positive regulation of locomotion BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.21112
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.20249
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, ESRRB, F3, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC 2.20249
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2, IDO1, SRC, XDH 2.20045
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.16599
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.14635
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, IDO1, MMP12, PTGS2, SRC 2.14218
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.14218
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.14218
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC 2.13124
[BP] GO:0043696 None CDK6, ESRRB 2.12588
[BP] GO:0043697 None CDK6, ESRRB 2.12588
[BP] GO:0010641 None F3, SRC 2.12588
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.12477
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.12413
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, ESRRB, FLT3, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.12413
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.1204
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.11777
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, TYR 2.11188
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.11188
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC, TYR 2.08108
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.04596
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.04386
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.04119
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, HSD11B2, IDO1, MMP12, PTGS2, SRC, TYR 2.036
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, IDO1, MMP12, PTGS2, SRC 2.02987
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, IDO1 2.02933
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.02932
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, SRC 2.02414
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, KDR, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.64144
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.99515
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS2, PTPN1 1.81588
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS2 1.79358
[CC] GO:0005783 None ADORA1, BCL2, CA4, CYP19A1, FLT3, GBA2, KDR, PTGS2, PTPN1, XDH 1.73745
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 11.7664
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, TNKS, TYR, XDH 11.7664
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 8.59166
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.19488
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 6.81425
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PTPN1, TNKS 5.53471
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.53471
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.22509
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 5.10191
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 4.73782
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.5712
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.5712
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, IDO1, PTGS2, SRC, XDH 4.51386
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.38759
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.28781
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.99169
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.82775
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.76822
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.64871
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.64569
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.59938
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.57522
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.49643
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.19842
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TYR 2.99046
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.85796
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.85796
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.83788
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.83788
[MF] GO:0003845 None HSD11B1, HSD11B2 2.83788
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.73642
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.73642
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.71789
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.71155
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.70071
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PTPN1, SRC 2.66417
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1 2.64144
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.51257
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.28163
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.24432
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.23366
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.22622
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.21697
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PTPN1, SRC 2.20156
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.12588
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.08108


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.9851
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.8236
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 6.3547
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.8236
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.7303
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, PTGS2, MMP9, MET, IGF1R 4.7031
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.7031
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.7031
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.6269
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 4.1266
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.4509
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2846
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.8658
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.3536
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.7713
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.3592
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.3704
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.4548
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.2666
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2666
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 1.9914
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.3353
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1229
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.9535
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.2808
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 2.0798
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0159
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7183
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7959
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.4978
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.186
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.3694
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4445
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0631
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3551
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.1824
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1231
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1737
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4275
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0631
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3533
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0921
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.0631
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2 1.3975
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2707
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.3514
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, PTGS2 1.0631
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0491
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0491
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.9602
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0491
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.0176
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.9412
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.8735
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9508
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8539
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7479
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8225
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.743
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7959
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8979
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.6167
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3007
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3521
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3897
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4133
Purine metabolism_Homo sapiens_hsa00230 XDH 0.403
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1 0.3723
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3896
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4686
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4561
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4686
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4671
Platelet activation_Homo sapiens_hsa04611 SRC 0.4977
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4798
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4984
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8567
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4977
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4977
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.5302
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7959
Axon guidance_Homo sapiens_hsa04360 MET 0.4928
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5704
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5549
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5583
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5622
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5704
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5702
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5622
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5549
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5704
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5622
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5704
Gap junction_Homo sapiens_hsa04540 SRC 0.5704
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0658
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.6121
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5704
Peroxisome_Homo sapiens_hsa04146 XDH 0.5756
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6114
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6121
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5902
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6282
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.6282
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6282
Bile secretion_Homo sapiens_hsa04976 CA2 0.6137
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.636
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6167
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6282
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6282
Shigellosis_Homo sapiens_hsa05131 SRC 0.6282
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6584
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6908
Malaria_Homo sapiens_hsa05144 MET 0.7018
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7077
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7047
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7077
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.7077
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7555
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7943
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8324
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8539
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8539
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8735
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8645
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1866
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.994
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0631
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3296


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)