TCM Prescription: Dan Lou Tablet



Prescription Description
Prescription IDTCMF367
Pinyin NameDan Lou Pian 
Chinese Name丹蒌片
English NameDan Lou Tablet
Function Description痰瘀互结所致的胸痹心痛, 症见胸闷胸痛, 憋气, 舌质紫暗, 苔白腻; 冠心病心绞痛见上述证候者
IndicationsCoronary heart disease, Angina pectoris
Disease ICD-11 Category BA80.Z [Coronary atherosclerosis, unspecified site, 冠状动脉粥样硬化,未特指部位 ];
BA40 [Angina pectoris, 心绞痛 ];
Human Tissues Associated with IndicationBrain, Heart
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH706 Trichosanthes kirilowii 瓜蒌皮 TCMH706 ITSAO4359-14
TCMH2309 Allium macrostemon 薤白 TCMH2309 ITSAL4510-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH700 Drynaria fortunei 骨碎补 TCMH700 GBVM3977-11
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 12.8554
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPER1, GPR35, GSK3B, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 12.8554
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPER1, GPR35, GSK3B, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 12.8554
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, ALPL, APP, AR, AXL, CA2, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GSK3B, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 11.6946
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPER1, GPR35, GSK3B, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 11.5108
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, EGFR, F10, F3, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, PTPN1, RELA, SRC, TEK, XDH 10.8341
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GSK3B, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, PTGES, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 10.7288
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPER1, GPR35, GSK3B, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KCNH2, KDR, MAOA, MET, MIF, PPARA, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.549
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPER1, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.5108
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.4779
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, NUAK1, PTPN1, RELA, SRC, TEK, XDH 10.3709
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.3463
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GPER1, GSK3B, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SLC6A4, SRC, TEK, TYR 10.1124
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, HSD17B3, MET, MIF, PPARA, PTGES 9.89308
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPER1, GPR35, GSK3B, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 9.89308
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 9.89308
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, RELA, RORC, SLC6A4, SMAD3, SRC, TERT 9.49815
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, CA2, CA6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GPER1, GSK3B, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 9.47569
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APP, AR, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, GSK3B, IGF1R, INSR, MMP2, PPARA, RELA, SLC6A4, SMAD3, SRC, TEK 9.26436
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPER1, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.24363
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPER1, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 9.04674
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, GPER1, GSK3B, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 8.91076
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 8.88613
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 8.55312
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 8.55113
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, PPARA, RELA, SMAD3, SRC, TEK, TYR 8.50531
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MIF, MMP2, MMP9, NUAK1, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TERT 8.40485
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 8.36609
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, PTGES, RELA, RORC, SLC6A4, SRC, TYR 8.31859
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, GPER1, HSD17B2, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TYR 8.31859
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, GPER1, PTGES, RELA, RORC, SLC6A4, SRC, TEK, TYR 8.28961
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA6, CA7, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FUT7, HSD17B3, HSPA1A, MIF, PIM1, PPARA, PTGES, TYR, XDH 8.1777
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, AR, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, INSR, PPARA, RELA, SLC6A4, SRC, TEK 8.08932
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TERT 7.96946
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, KDR, MAP2K1, MIF, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 7.96946
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, AR, EGFR, FLT3, GPER1, INSR, KDR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TEK, XDH 7.95417
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, HSD17B1, HSD17B2, HSD17B3 7.94801
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 7.90902
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 7.90902
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK, TERT 7.89798
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, GPER1, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, RELA, TEK, TERT 7.76012
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, CACNA1C, CYP19A1, CYP1B1, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 7.6878
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGES, RELA, SRC, TERT 7.67128
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APP, AR, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GPER1, GSK3B, IGF1R, INSR, KDR, MMP2, RELA, RORC, SLC6A4, SMAD3, SRC 7.65097
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, AR, DUSP3, EGFR, FLT3, GPER1, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TEK, XDH 7.59071
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPER1, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 7.51211
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 7.49401
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.4233
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, XDH 7.29992
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, AR, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, GSK3B, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, RELA, SLC6A4, SMAD3, SRC, TERT, XDH 7.2474
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK, TERT 7.2474
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, AR, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, GSK3B, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, RELA, SLC6A4, SMAD3, SRC, TERT, XDH 7.23168
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.20908
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF, PTGES 7.1305
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 7.0277
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, APP, AR, AXL, CA2, CACNA1C, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPER1, GPR35, GSK3B, HSPA1A, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIM1, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 6.98728
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 6.98728
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, ESRRB, FABP3, FLT3, GPER1, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.98728
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, ESRRB, FABP3, FLT3, GPER1, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.98728
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, XDH 6.91738
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF, PTGES 6.90235
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, CA2, CACNA1C, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GSK3B, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, MET, MIF, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 6.89542
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.87692
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.87149
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.84824
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7 6.84824
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, AR, CYP19A1, DUSP3, EGFR, ESR1, ESR2, GPER1, GSK3B, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 6.82465
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, APP, AR, AURKB, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, GPER1, GSK3B, HSPA1A, INSR, MAP2K1, MAP3K7, MET, MIF, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 6.82413
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, GPER1, GSK3B, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 6.79828
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.7965
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.74937
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 6.61345
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.55925
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, GPR35, GSK3B, HSPA1A, IGF1R, KCNH2, KDR, MAP2K1, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 6.45235
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPER1, GPR35, GSK3B, HSPA1A, IGF1R, INSR, MAP2K1, MAP3K7, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TERT, XDH 6.45235
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GSK3B, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, MMP9, PIM1, PPARA, RELA, RORC, SMAD3, SRC, TEK, TYR 6.35559
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, ESRRB, FLT3, GPER1, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, TEK, XDH 6.31726
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, EGFR, GPER1, GPR35, GSK3B, HSPA1A, INSR, KCNH2, MAP2K1, MIF, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TERT 6.29969
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 6.28814
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, APP, AR, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.25202
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PPARA, PTGES 6.20897
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC, SRC 6.18162
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PPARA, PTPN1, SRC, TEK, XDH 6.08851
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 6.02691
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.96423
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 5.96089
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, ESR1, F3, FLT3, GPER1, GSK3B, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.95358
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, APP, AR, AXL, CA2, CYP1B1, EGFR, ESRRB, F3, GPER1, HSPA1A, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIM1, RELA, SMAD3, SRC, TEK, TERT 5.94106
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, FLT3, GPER1, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, TEK, XDH 5.89845
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7 5.858
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, GPR35, GSK3B, HSPA1A, IGF1R, KCNH2, KDR, MAP2K1, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 5.82077
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, EGFR, ESR1, GPER1, GSK3B, IGF1R, INSR, MMP2, MMP9, RELA, RORC, SLC6A4, SRC 5.79615
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FABP3, FABP4, FUT7, MET, MIF, PPARA, PTGES 5.78206
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC 5.60964
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.59011
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, EGFR, ESR1, FLT3, GPER1, GSK3B, IGF1R, INSR, MMP2, RELA, SLC6A4, SMAD3, SRC 5.59011
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF, PTGES 5.59011
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, GPER1, INSR, MET, SRC, TEK, XDH 5.57667
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, GPER1, KDR, MAP2K1, MIF, PTPN1, SRC, TEK 5.57628
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APP, AXL, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, GPER1, GPR35, INSR, KCNH2, MET, SMAD3, SRC, TERT 5.54759
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, GPER1, HSD17B1, HSD17B2, HSD17B3 5.52452
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, RORC, SLC6A4, SRC 5.49614
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PTPN1, RELA, SRC, TEK, XDH 5.49407
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, TEK, XDH 5.46342
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC, SRC 5.35359
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 5.27904
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, GPER1, INSR, MIF, SLC6A4, SRC, TERT 5.25446
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, APP, AURKB, CDC25B, EGFR, ESR1, F3, FLT3, GPER1, GSK3B, HSPA1A, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.25003
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, DUSP3, EGFR, ESR1, ESR2, GPER1, GSK3B, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, RELA, SMAD3, SRC, TERT, XDH 5.17632
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CYP19A1, EGFR, GPER1, GSK3B, INSR, KCNH2, MIF, MMP12, SLC6A4, SMAD3, SRC, TERT 5.10029
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.07745
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.02991
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GPER1, GSK3B, IGF1R, INSR, MMP2, PPARA, RELA, SLC6A4, SRC, TEK, TYR 5.01795
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.0047
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.90988
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGES 4.8898
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, F3, FABP4, GPER1, KDR, MAP2K1, MET, MIF, MMP12, PPARA, RELA, SMAD3, TEK 4.85512
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 4.85512
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GPER1, HSPA1A, MAP3K7, MMP12, MMP2, PPARA, PTPN1, RELA, SMAD3, SRC, TEK 4.83046
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, GSK3B, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 4.83046
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GSK3B, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TEK 4.7975
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, GPER1, KDR, MAP2K1, MIF, SRC, TEK 4.7975
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC 4.76223
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AXL, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK 4.75903
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 4.69585
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, FUT7, GSK3B, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.63259
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GPER1, GSK3B, IGF1R, INSR, PPARA, RELA, SRC, TEK 4.62047
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GPER1, GSK3B, IGF1R, INSR, MMP2, PPARA, RELA, SLC6A4, SRC, TEK, TYR 4.61101
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, ESR1, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, MMP1, MMP9, SMAD3, SRC, TEK 4.59974
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.56783
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, GPER1, GPR35, INSR, KCNH2, MET, SMAD3 4.53862
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, GPER1, GSK3B, HSPA1A, MAP2K1, MAP3K7, MIF, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, RELA, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 4.53862
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TEK 4.43381
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 4.41902
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, FLT3, GPER1, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.41575
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GSK3B, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TYR, XDH 4.3593
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, GSK3B, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MIF, NUAK1, PTPN1, TERT, XDH 4.35758
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, ESR1, FLT3, MAP2K1, MET, MIF, PIM1, SRC, TEK, TYR 4.32258
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, GPER1, GSK3B, HSPA1A, MIF, MMP9, PTPN1, RELA, SMAD3, SRC, TERT 4.28298
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, RORC 4.27637
[BP] GO:0070920 None EGFR, ESR1, MAP2K1, TERT 4.24773
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 4.20782
[BP] GO:0032787 None ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PPARA, PTGES 4.18149
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP3K7, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.18071
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, CACNA1C, CYP1B1, EGFR, GPER1, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MIF, NUAK1, PTPN1, RELA, SRC, TEK 4.16513
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 4.16153
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CACNA1C, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GPER1, GPR35, GSK3B, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 4.15018
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, GPER1, GSK3B, IGF1R, INSR, MMP2, RELA, SLC6A4, SRC 4.15018
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, GSK3B, HSPA1A, IGF1R, KDR, MAP2K1, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TERT, XDH 4.13955
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC 4.13069
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, MAP2K1, RELA, SMAD3, TYR 4.13043
[BP] GO:0010675 None ESRRB, GPER1, GSK3B, INSR, PPARA, RORC, SRC 4.12929
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPER1, GSK3B, INSR, KDR, MAP2K1, MIF, NUAK1, PIM1, PPARA, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.10551
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGES, TERT 4.10006
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SLC6A4, SRC 4.06538
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.02716
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.01402
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, MAP2K1, SRC 4.00041
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, GPER1, HSPA1A, MAP2K1, PTGES, SLC6A4, SMAD3, TERT, XDH 4.00041
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC 3.99974
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CES1, CYP19A1, CYP1A1, CYP1B1, HSD17B3, MAOA, TYR 3.98203
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TERT 3.97122
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GPER1, INSR, MAOA, SLC6A2, SLC6A4, SMAD3 3.97054
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 3.91879
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, GPER1, HSPA1A, IGF1R, MET, MIF, MMP9, PTPN1, RELA, SRC, XDH 3.88803
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 3.86545
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, GPER1, GSK3B, IGF1R, INSR, MMP2, RELA, SLC6A4, SRC 3.85845
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.84354
[BP] GO:0042058 None ADORA1, ADRA2A, APP, EGFR, GPER1, MMP9 3.83228
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 3.82646
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.81459
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, MAP2K1, SRC 3.79055
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC 3.77251
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, MAP2K1, MMP2, MMP9, SLC6A4, SRC 3.76165
[BP] GO:0071396 cellular response to lipid AR, AXL, EGFR, ESR1, FLT3, GPER1, RELA, RORC, SLC6A4, SRC 3.72352
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT 3.71097
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GPER1, GSK3B, IGF1R, INSR, RELA, SRC 3.6659
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, EGFR, FLT3, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TEK 3.66181
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT 3.66181
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT 3.66181
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, GPER1, PPARA, RORC, SRC, TEK 3.66181
[BP] GO:0010676 None ESRRB, GPER1, INSR, PPARA, SRC 3.65608
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, GSK3B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, SRC, TEK 3.638
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, GSK3B, PPARA, RORC, SLC6A4, SRC 3.638
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, HSPA1A, MIF, MMP9, PTPN1, RELA, SRC, TERT 3.6373
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, HSD17B3, MIF, PTGES 3.63533
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.60712
[BP] GO:0010906 None ESRRB, GSK3B, INSR, PPARA, RORC, SRC 3.59535
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 3.58618
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 3.5731
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 3.56669
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, EGFR, FLT3, GPER1, RELA, SRC 3.5324
[BP] GO:1901184 None ADORA1, ADRA2A, APP, EGFR, GPER1, MMP9 3.52662
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, GSK3B, IGF1R, INSR, KDR, MAP3K7, MET, MIF, MMP2, MMP9, PTPN1, RELA, SMAD3, SRC, TEK 3.51203
[BP] GO:0003018 None ADORA1, ADRA2A, EGFR, GPER1, SLC6A4, SRC, TEK 3.51098
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGES 3.50669
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, CACNA1C, EGFR, GPER1, KDR, MIF, SRC 3.4887
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.46491
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, EGFR, FLT3, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TEK 3.45598
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, GSK3B, HSPA1A, INSR, KDR, MAP3K7, MET, PPARA, PTPN1, RELA, SMAD3 3.45594
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, GPER1, HSPA1A, INSR, MAP2K1, MIF, PIM1, SLC6A4, SMAD3, SRC, TERT 3.45182
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, MAP3K7, PIM1, RELA 3.45113
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GPER1, PPARA, RELA, SMAD3, TEK 3.45113
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.43945
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, GSK3B, HSPA1A, IGF1R, KDR, MAP2K1, MIF, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TERT, XDH 3.42998
[BP] GO:0050730 None ADORA1, ADRA2A, APP, EGFR, FLT3, MIF, PTPN1, SRC 3.39002
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, CACNA1C, EGFR, GPER1, GSK3B, MIF, MMP12, PTPN1, SMAD3, SRC 3.37417
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2, HSD17B3 3.36418
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, F3, GPER1, GSK3B, INSR, KDR, MAP2K1, PIM1, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.36418
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 3.36418
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CES1, CYP1A1, CYP1B1, KDR, RELA, SLC6A4, SRC 3.33093
[BP] GO:0051254 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT 3.27712
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, GPER1, MMP12, PPARA, SMAD3, TEK 3.26637
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, CA2, CA7, CACNA1C, GPER1, GPR35, KCNH2, MIF, MMP9, SLC6A4 3.26479
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT 3.26479
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, GPER1, GSK3B, INSR, PPARA, RORC, SRC 3.22352
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 3.22352
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, GPER1, GSK3B, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.22187
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.22187
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK 3.22001
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, EGFR, FLT3, INSR, MAP2K1, MAP3K7, MIF, PTPN1, SRC 3.2099
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, GPER1, PPARA, SMAD3, TEK 3.20493
[BP] GO:0045913 None ESRRB, GPER1, INSR, PPARA, SRC 3.15517
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 3.15447
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.14347
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.14347
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PIM1, PPARA, PTGES, TYR 3.13118
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, CA2, CYP19A1, DUSP3, ESR1, ESRRA, GPER1, HSPA1A, MAP3K7, MIF, MMP12, MMP2, PTPN1, RELA, SMAD3, SRC 3.11509
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, HSPA1A, MAOA 3.11509
[BP] GO:1902893 None PPARA, RELA, SMAD3, TERT 3.11509
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.11509
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, CDC25B, CES1, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GSK3B, KDR, MAP2K1, MET, MIF, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TERT 3.10691
[BP] GO:0010628 positive regulation of gene expression APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, GSK3B, HSPA1A, INSR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SLC6A4, SMAD3, SRC, TERT 3.0971
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, GPER1 3.0971
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.08345
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 3.07766
[BP] GO:0051098 regulation of binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SMAD3, SRC, TERT 3.07766
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, AR, EGFR, ESR1, FLT3, GPER1, INSR, RELA, SRC 3.07766
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APP, AR, AURKB, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, GPER1, GSK3B, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TERT, XDH 3.06729
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, CA2, CYP1B1, ESRRB, F3, GPER1, INSR, KDR, MAP2K1, PIM1, RELA, SMAD3, SRC, TEK, TERT 3.06729
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, GPER1, SLC6A4 3.04999
[BP] GO:0051172 None ADRA2A, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, IGF1R, MIF, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TERT, XDH 3.04494
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 3.03544
[BP] GO:0045893 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT 3.03544
[BP] GO:1903508 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT 3.03544
[BP] GO:1902680 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT 3.03422
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD17B1, HSD17B2, HSD17B3 3.02219
[BP] GO:0071383 None AR, EGFR, FLT3, GPER1, SRC 3.01923
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, GSK3B, HSPA1A, INSR, KDR, MAP3K7, PPARA, PTPN1 3.01223
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, GPER1, MMP2, MMP9, TERT 2.98898
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3, TERT 2.97944
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.96976
[BP] GO:0045742 None ADORA1, ADRA2A, GPER1, MMP9 2.95612
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGES 2.95612
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, APP, AR, CACNA1C, CSNK2A1, EGFR, GPER1, GSK3B, MIF, MMP12, PTPN1, SMAD3, SRC, TERT 2.945
[BP] GO:0009115 None AOX1, XDH 2.93127
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, GPER1, GPR35, KCNH2, SMAD3 2.92601
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, SRC 2.92599
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, XDH 2.92561
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.91905
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.89413
[BP] GO:1901186 None ADORA1, ADRA2A, GPER1, MMP9 2.87757
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation GPER1, MMP2, MMP9, TERT 2.87757
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KCNH2, KDR, RELA, SRC 2.86188
[BP] GO:0043255 regulation of carbohydrate biosynthetic process ESRRB, GPER1, GSK3B, INSR, PPARA 2.85577
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.84668
[BP] GO:0003013 None ADORA1, ADRA2A, EGFR, GPER1, SLC6A4, SRC, TEK 2.84668
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, GPER1, MMP9, SMAD3, SRC, XDH 2.838
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, RELA, TYR 2.838
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, GPER1, KDR, SRC 2.81556
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.80974
[BP] GO:0010629 None APP, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, KDR, MAP2K1, MIF, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT, XDH 2.80862
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, XDH 2.78096
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, GPER1, MIF, MMP12, SLC6A4, SRC 2.77145
[BP] GO:1901224 None APP, EGFR, MAP3K7, RELA 2.7707
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 2.7494
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PIM1, PPARA, PTGES, TYR 2.74352
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, GSK3B, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.74026
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.74002
[BP] GO:1903798 None EGFR, ESR1, MAP2K1 2.73237
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, XDH 2.72041
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, GPER1, SLC6A4 2.6991
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, GPER1, SLC6A4 2.6991
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.6951
[BP] GO:0001819 positive regulation of cytokine production ADRA2A, CYP1B1, HSPA1A, MAP3K7, MIF, MMP12, RELA, SMAD3, SRC 2.68343
[BP] GO:0031331 positive regulation of cellular catabolic process ADRA2A, ESRRB, GSK3B, HSPA1A, INSR, KDR, MAP3K7, PPARA, PTPN1 2.68343
[BP] GO:0045862 positive regulation of proteolysis ADRA2A, APP, F3, GPER1, GSK3B, HSPA1A, SMAD3, SRC, XDH 2.68343
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PIM1, PPARA, PTGES, TYR 2.67599
[BP] GO:0001954 positive regulation of cell-matrix adhesion GSK3B, KDR, SMAD3, TEK 2.67599
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.65854
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, GSK3B, HSPA1A, MET, MMP1, SRC 2.63332
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, CSNK2A1, EGFR, ESR1, ESR2, GPER1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK 2.63302
[BP] GO:2001236 regulation of extrinsic apoptotic signaling pathway AR, GPER1, HSPA1A, RELA, SRC, TERT 2.59485
[BP] GO:0042493 response to drug AKR1B1, AXL, CYP1A1, CYP1B1, EGFR, FABP3, KCNH2, KDR, RELA, SLC6A2, SLC6A4, SRC 2.58505
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, EGFR, INSR, MAP2K1, MAP3K7, PTPN1, SRC 2.58505
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTPN1, SRC 2.57617
[BP] GO:2000351 None GPER1, KDR, TEK, TERT 2.54067
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, GPER1, KDR, TEK 2.53633
[BP] GO:0033590 None EGFR, RELA 2.53401
[BP] GO:0046110 None AOX1, XDH 2.53401
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53401
[BP] GO:0002520 None CACNA1C, SMAD3 2.53401
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, GPER1, MMP9, SMAD3, SRC, XDH 2.52111
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA 2.51815
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CES1, CYP19A1, HSD17B3, TYR 2.50564
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.48479
[BP] GO:0060341 regulation of cellular localization ADRA2A, APP, AR, CACNA1C, CSNK2A1, EGFR, GPER1, GSK3B, MAP2K1, PTPN1, SMAD3, SRC, TERT 2.4756
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPER1, GPR35, GSK3B, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.47222
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.47222
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.47222
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.47222
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.47222
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, GPER1, GPR35, KCNH2, SMAD3 2.47066
[BP] GO:0050678 None AR, EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 2.46027
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, ESR2, HSPA1A, MAP3K7, RELA 2.45607
[BP] GO:0001952 regulation of cell-matrix adhesion GSK3B, KDR, SMAD3, SRC, TEK 2.43836
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, HSPA1A, RELA, SRC, TERT 2.43836
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, RELA, SMAD3, SRC 2.43819
[BP] GO:0046328 regulation of JNK cascade APP, DUSP3, EGFR, IGF1R, MAP3K7, PTPN1 2.42187
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.40589
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.40589
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, GSK3B, KDR, SMAD3, TEK 2.38787
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.38733
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, HSD17B3, MIF, PTGES 2.38416
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, AXL, CA2, CACNA1C, CYP1B1, EGFR, ESR1, INSR, MET, MMP2, RELA, SLC6A4, SMAD3, SRC, TEK 2.37861
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, MIF, PTPN1, SRC 2.37779
[BP] GO:0051223 None ACHE, ADRA2A, APP, CACNA1C, EGFR, GPER1, GSK3B, MIF, MMP12, PTPN1, SMAD3, SRC 2.375
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK 2.36911
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK 2.36911
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA, SRC 2.36125
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.36111
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK 2.36098
[BP] GO:0050679 None AR, EGFR, F3, KDR, MMP12, TEK 2.36098
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, GPER1, KDR, TEK, TERT 2.36098
[BP] GO:0002793 None ACHE, ADORA1, EGFR, GPER1, MIF, MMP12, SRC 2.35438
[BP] GO:0030155 regulation of cell adhesion ALOX15, CYP1B1, DUSP3, GSK3B, KDR, MAP3K7, NUAK1, PPARA, SMAD3, SRC, TEK 2.34408
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.33724
[BP] GO:1901654 None AKR1B1, AR, CSNK2A1, EGFR, RELA, SRC 2.32449
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, CACNA1C, EGFR, GPER1, MIF, MMP12, SRC 2.30584
[BP] GO:1902895 None RELA, SMAD3, TERT 2.29944
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.29944
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.29944
[BP] GO:0006145 None AOX1, XDH 2.29463
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.29463
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.29463
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, EGFR, MET, PPARA, RELA, SMAD3 2.28837
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CACNA1C, CYP19A1, EGFR, GPER1, MIF, MMP12, SLC6A4, SRC 2.28792
[BP] GO:0050920 regulation of chemotaxis CYP19A1, F3, KDR, MET, MIF, SMAD3 2.28792
[BP] GO:1903532 None ACHE, CYP19A1, EGFR, GPER1, MIF, MMP12, SLC6A4, SRC 2.28256
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.25541
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.24433
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.22759
[BP] GO:1901222 None APP, EGFR, MAP3K7, RELA 2.22169
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, GSK3B, KDR, SMAD3, SRC, TEK 2.22167
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, AXL, CA2, CYP1B1, EGFR, GSK3B, HSPA1A, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PTPN1, RELA, SRC, TERT 2.2147
[BP] GO:0051894 None KDR, SMAD3, TEK 2.20964
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.20964
[BP] GO:0070201 None ACHE, ADRA2A, APP, CACNA1C, EGFR, GPER1, GSK3B, MIF, MMP12, PTPN1, SMAD3, SRC 2.20627
[BP] GO:0001775 cell activation ADRA2A, ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, RORC, SMAD3, SRC 2.18884
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.18884
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGES, RELA, SRC 2.1706
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, RELA, SLC6A4, TYR 2.16916
[BP] GO:0050927 None F3, KDR, SMAD3 2.16384
[BP] GO:0043434 None FABP3, GPER1, INSR, PPARA, RELA, SRC, TEK 2.16384
[BP] GO:0034097 response to cytokine ALOX15, AXL, FABP4, FLT3, GPER1, GSK3B, PTGES, RELA, SRC 2.1617
[BP] GO:0045595 regulation of cell differentiation APP, AR, AXL, CA2, EGFR, ESRRA, ESRRB, GPER1, GSK3B, KDR, MAP2K1, PPARA, RELA, RORC, SLC6A4, SMAD3, TERT, XDH 2.1617
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.16091
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, GPER1, MIF, PPARA, SMAD3, TEK 2.16091
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, KDR, MET, MIF, SMAD3 2.16091
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, RELA, SMAD3, SRC 2.16091
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.14996
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, GPER1, GSK3B, MIF, MMP12, SMAD3, SRC 2.1488
[BP] GO:0023014 signal transduction by protein phosphorylation EGFR, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, TEK 2.1426
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, GPER1, KDR, TEK 2.13898
[BP] GO:0097746 None ADORA1, ADRA2A, EGFR, GPER1, SLC6A4 2.13887
[BP] GO:0035296 None ADORA1, ADRA2A, EGFR, GPER1, SLC6A4 2.13887
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, EGFR, ESR1, MET, SMAD3, SRC 2.13887
[BP] GO:0050926 None F3, KDR, SMAD3 2.13291
[BP] GO:0005979 None ESRRB, GSK3B, INSR 2.13291
[BP] GO:1903393 None KDR, SMAD3, TEK 2.13291
[BP] GO:0006693 None CES2, MIF, PTGES 2.13291
[BP] GO:0006692 None CES2, MIF, PTGES 2.13291
[BP] GO:0010962 None ESRRB, GSK3B, INSR 2.13291
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, CDC25B, CSNK2A1, CYP1A1, EGFR, GPER1, HSPA1A, INSR, MIF, TERT 2.13291
[BP] GO:0051248 None APP, CSNK2A1, DUSP3, EGFR, FABP4, GPER1, HSPA1A, IGF1R, MIF, MMP9, PTPN1, RELA, SMAD3, SRC, XDH 2.13291
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.13291
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PTPN1, RELA, SRC 2.12974
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.12974
[BP] GO:0010641 None F3, SRC 2.12974
[BP] GO:0007598 None F10, F3 2.12974
[BP] GO:1904062 None ADRA2A, APP, CACNA1C, GPER1, GPR35, KCNH2, MMP9 2.10754
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.09299
[BP] GO:1903827 regulation of cellular protein localization APP, AR, CSNK2A1, EGFR, GPER1, GSK3B, PTPN1, SMAD3, SRC, TERT 2.09012
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HSD17B3 2.08601
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CACNA1C, CYP19A1, EGFR, GPER1, MIF, MMP12, SLC6A4, SRC 2.06675
[BP] GO:0045934 None ADRA2A, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT 2.06675
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, SMAD3, SRC, TERT 2.06675
[BP] GO:0046683 response to organophosphorus APP, RELA, SLC6A4, TEK, TYR 2.06675
[BP] GO:0008209 androgen metabolic process CYP19A1, ESR1, HSD17B3 2.05217
[BP] GO:0050880 None ADORA1, ADRA2A, EGFR, GPER1, SLC6A4 2.03849
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, PTGES, RELA, SRC 2.03709
[BP] GO:0001817 regulation of cytokine production ADRA2A, AXL, CYP1B1, HSPA1A, MAP3K7, MIF, MMP12, RELA, SMAD3, SRC 2.03709
[BP] GO:0035150 None ADORA1, ADRA2A, EGFR, GPER1, SLC6A4 2.02585
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.02507
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGES 2.01476
[BP] GO:0007176 None ADORA1, ADRA2A, APP 2.01476
[BP] GO:0052548 None APP, CSNK2A1, F3, GPER1, MMP9, SMAD3, SRC, XDH 2.01289
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.00812
[BP] GO:0042391 None ADORA1, APP, CACNA1C, GPER1, GPR35, KCNH2, KDR, SRC 2.00812
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CACNA1C, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GPER1, GPR35, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 4.50271
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.48195
[CC] GO:0009986 cell surface ACHE, APP, AXL, CA4, EGFR, F3, KCNH2, MET, MIF, SLC6A2, TEK 3.03544
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GPER1, GSK3B, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MIF, MMP2, MMP9, PIM1, PTGES, PTPN1, RELA, SLC6A4, SMAD3, SRC, TERT, TYR, XDH 3.03422
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALOX5, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, F10, F3, FLT3, FUT7, GPER1, GPR35, GSK3B, HSD17B2, HSD17B3, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 2.96128
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, APP, AXL, CA4, F10, F3, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A4, TEK 2.84575
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CA6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GPER1, GSK3B, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, RORC, SHBG, SMAD3, SRC, TERT, TYR, XDH 2.81556
[CC] GO:0005783 None ADORA1, APP, CA4, CES1, CES2, CYP19A1, FLT3, GPER1, HSD17B3, HSPA1A, KDR, MAP2K1, PTPN1, XDH 2.7707
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 2.76575
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 2.7494
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, ALOX15, APP, AXL, CA2, CA4, CACNA1C, DUSP3, EGFR, F10, F3, FLT3, GPER1, GPR35, IGF1R, INSR, KCNH2, KDR, MET, SLC6A2, SLC6A4, SRC, TEK 2.55393
[CC] GO:0044432 endoplasmic reticulum part APP, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, F10, FLT3, GPER1, HSD17B2, HSD17B3, PTGES, PTPN1 2.47222
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APP, CA4, EGFR, GPER1, HSPA1A, KCNH2, PTGES, SRC, TYR 2.44991
[CC] GO:0031233 None CA4, F10, F3 2.40058
[CC] GO:0098589 membrane region APP, EGFR, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 2.29439
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, EGFR, TEK 2.24214
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CA6, CACNA1C, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GPER1, GSK3B, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, RORC, SHBG, SMAD3, SRC, TERT, TYR, XDH 2.16091
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 13.9576
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 12.278
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, F10, F3, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, PTPN1, SRC, TEK, TERT, TYR, XDH 11.5262
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 9.9316
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 7.95417
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 7.95417
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, RORC, SHBG 7.52399
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 7.40163
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.2474
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA6, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 6.85093
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 6.61345
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, MAP3K7, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 6.56973
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.54579
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, GPER1, HSD17B1, IGF1R, INSR, SHBG 6.31296
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, MAP3K7, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 6.3032
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 6.24139
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 6.13248
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, PPARA, RORC, SMAD3, TEK 5.72835
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PPARA, SLC6A4, SRC, TEK 5.66109
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, GPER1, HSD17B1, PPARA, RORC, SHBG 5.6358
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SLC6A4, SMAD3, SRC 5.63254
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 5.57667
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SLC6A4, SMAD3, SRC 5.52136
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH 5.49614
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 5.49407
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 5.41106
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 5.25306
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 5.07771
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TERT 4.81936
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 4.64042
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GSK3B, HSPA1A, KCNH2, MET, MIF, PPARA, PTPN1, RELA, SLC6A4, SMAD3, SRC, TEK 4.43418
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 4.43161
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MAP3K7, MET, MIF, MMP9, RELA, SLC6A4, SMAD3, TERT, TYR, XDH 4.32881
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 4.11792
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.92669
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 3.87106
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, HSD17B3, XDH 3.83228
[MF] GO:0043168 anion binding ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTGES, RELA, SRC, TEK, XDH 3.76994
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.66348
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 3.61816
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.48201
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.33177
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 3.09385
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, MAP2K1, MAP3K7, SMAD3 3.08126
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 2.98898
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.93127
[MF] GO:0008013 beta-catenin binding AR, CSNK2A1, ESR1, GSK3B, SMAD3 2.838
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 2.83675
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, PTGES, SRC, XDH 2.75666
[MF] GO:0008134 transcription factor binding AR, ESR1, ESRRB, FLT3, GSK3B, PIM1, PPARA, RELA, SMAD3, SRC, TERT 2.75355
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RELA, RORC, SHBG, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.7164
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.70506
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 2.59485
[MF] GO:0005330 None SLC6A2, SLC6A4 2.53401
[MF] GO:0047374 None CES1, CES2 2.53401
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.40058
[MF] GO:0047485 None CSNK2A1, HSPA1A, MAP2K1, RELA, TERT 2.38787
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, GSK3B, PTPN1, RELA, SMAD3, SRC 2.38604
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 2.36325
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.36125
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.29463
[MF] GO:0032795 None ADORA1, ADRA2A 2.29463
[MF] GO:0005497 None AR, SHBG 2.29463
[MF] GO:0051425 None APP, INSR 2.29463
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, XDH 2.29314
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 2.26744
[MF] GO:0001085 RNA polymerase II transcription factor binding AR, ESR1, GSK3B, PPARA, SMAD3 2.24433
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 2.23748
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, GSK3B, PTPN1, RELA, SMAD3, SRC 2.22352
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD17B1, HSD17B2, HSD17B3 2.20301
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.20143
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AR, AXL, EGFR, FLT3, KCNH2, RELA, SLC6A4, SMAD3, TERT, TYR, XDH 2.13586
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.13291
[MF] GO:0043559 insulin binding IGF1R, INSR 2.12974
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD17B1, HSD17B2, HSD17B3 2.09299
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.06675
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, PPARA, RELA, RORC, SMAD3 2.04127
[MF] GO:0016229 steroid dehydrogenase activity HSD17B1, HSD17B2, HSD17B3 2.01476
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.01476
[MF] GO:0031625 None EGFR, GSK3B, HSPA1A, KCNH2, RELA, SMAD3, SRC 2.00924


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.9352
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MAP3K7, MET, EGFR, IGF1R 8.9352
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA14 10.4116
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, GPER1, MMP9, ESR1, EGFR, ESR2, HSPA1A 8.0672
Pathways in cancer_Homo sapiens_hsa05200 AR, GSK3B, MAP2K1, SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, RELA, IGF1R 5.9578
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 6.9776
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, ALOX15, CACNA1C, CYP2C19, SLC6A4 6.4412
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9, EGFR 6.4412
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.6708
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, HSD17B3, AKR1B1, TYR, CYP2C19, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES, CES1 5.3572
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, MAP2K1, SRC, ESR1, ESR2, RELA 5.1866
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, MAP2K1, EGFR, RELA, IGF1R 4.7118
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.6249
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, INSR, KDR, TEK, MET, EGFR, RELA, IGF1R 4.43
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.1255
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, MAP2K1, INSR, KDR, TEK, MET, EGFR, RELA, IGF1R 4.1024
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, DUSP3, CACNA1C, MAP3K7, EGFR, RELA, CDC25B, HSPA1A 4.1024
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, INSR, TEK, EGFR, RELA, IGF1R 4.43
Focal adhesion_Homo sapiens_hsa04510 GSK3B, MAP2K1, SRC, KDR, MET, EGFR, IGF1R 3.8655
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3, RELA 3.3902
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C, EGFR 3.5874
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, INSR, ADORA1, CACNA1C, ADRA2A 3.3902
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.2791
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, INSR, PPARA, RELA 3.2791
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.0393
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.2791
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF, TYR 3.9918
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, SMAD3, EGFR, RELA 3.0618
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, CYP2C19, PTGES 3.1521
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET, EGFR 3.058
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, SMAD3, INSR, EGFR, IGF1R 3.038
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1, MAP3K7, RELA, HSPA1A 3.0163
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR, RELA 3.058
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SMAD3, SRC, MMP9, RELA 2.8955
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, MAP2K1, SMAD3, ESRRB, IGF1R 2.9404
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, EGFR, IGF1R 3.038
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1, CYP2C19 3.058
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.058
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.5119
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, MAP2K1, SRC, EGFR 2.7755
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, MAP2K1, MAP3K7, RELA 2.5025
cAMP signaling pathway_Homo sapiens_hsa04024 MAP2K1, ADORA1, CACNA1C, PPARA, RELA 2.3647
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.4307
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, MAP3K7, RELA, HSPA1A 2.3622
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP2C19 2.8633
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, MAP2K1, SRC, ESR1 2.3622
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, MAP3K7, RELA, HSPA1A 2.3622
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, ADORA1, RELA 2.3437
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA, EGFR, RELA 2.2118
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, SMAD3, CSNK2A1, MAP3K7 2.1596
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, MAP2K1, INSR 2.1863
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, INSR, PPARA, RELA 2.0901
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, EGFR 2.026
Influenza A_Homo sapiens_hsa05164 GSK3B, MAP2K1, RELA, HSPA1A 1.8931
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, MAP2K1, EGFR 2.3647
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, MAP2K1, SRC, RELA 1.8162
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.2193
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.3185
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, MAP2K1, RELA 2.0901
Glioma_Homo sapiens_hsa05214 MAP2K1, EGFR, IGF1R 2.1931
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, MAP2K1, SMAD3 2.2118
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1931
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, SMAD3, RELA 2.0901
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.7929
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, RELA, IGF1R 1.8256
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.7212
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, CACNA1C 1.6774
Melanogenesis_Homo sapiens_hsa04916 GSK3B, MAP2K1, TYR 1.7799
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, SMAD3, TERT, RELA 1.427
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, MAP2K1, RELA 1.5911
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, MAP3K7, RELA 1.8324
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.5682
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4076
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, EGFR 1.8931
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, MAP3K7, IGF1R 1.5682
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2983
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.51
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3081
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, INSR, EGFR 1.425
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, MAOA, CACNA1C 1.5272
Cell cycle_Homo sapiens_hsa04110 GSK3B, SMAD3, CDC25B 1.5682
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, ADRA2A 1.3675
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC, RELA 2.1931
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 CACNA1C 0.3473
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.0901
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1931
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3747
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.3747
Platelet activation_Homo sapiens_hsa04611 SRC 0.4035
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.4966
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.6148
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC, EGFR 1.0861
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C, EGFR 0.6832
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.6847
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.684
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.2229
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4242
Apoptosis_Homo sapiens_hsa04210 MAP2K1, RELA 0.8236
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP, CACNA1C 1.3128
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8254
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7575
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B, SMAD3 0.777
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4641
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.8771
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4641
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4731
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.4756
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4671
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.472
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.4641
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9245
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4731
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4807
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.9154
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4849
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.4927
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4911
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4821
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4907
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4907
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, RELA 1.0159
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4835
Small cell lung cancer_Homo sapiens_hsa05222 RELA 0.4907
Peroxisome_Homo sapiens_hsa04146 XDH 0.4927
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, EGFR 1.0346
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4934
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4927
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5045
Pertussis_Homo sapiens_hsa05133 RELA 0.5134
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5064
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5156
Bile secretion_Homo sapiens_hsa04976 CA2 0.5252
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1121
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5156
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5385
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1258
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5586
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP2C19 3.0163
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2126
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.2573
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.2064
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.2868
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.3176
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.3176
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.3128
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2868
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.3298
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.3732
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.3215
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6142
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, EGFR 1.4076
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.4016
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3781
Legionellosis_Homo sapiens_hsa05134 RELA, HSPA1A 1.4171
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6455
Malaria_Homo sapiens_hsa05144 MET 0.6472
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6455
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6576
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6523
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.4978
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, CACNA1C 1.51
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.716
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7091
Prion diseases_Homo sapiens_hsa05020 MAP2K1, HSPA1A 1.7224
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8199
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1, EGFR 1.8931
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7991
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8248
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.787
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8199
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7093
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8477
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8094
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8356
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0161
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8771
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.1961
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0812
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.058
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3732


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)