TCM Prescription: Cu Zhi Xiang Fu Pills



Prescription Description
Prescription IDTCMF3660
Pinyin NameCu Zhi Xiang Fu Wan
Chinese Name醋制香附丸
English NameCu Zhi Xiang Fu Pills
Function Description症积, 痛经, 月经失调
IndicationsDysmenorrhea disorder, Dysmenorrhea, Irregular menstruation
Disease ICD-11 Category SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ];
GA34.3 [Dysmenorrhoea, 痛经 ];
GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2473 Leonurus japonicus 益母草 TCMH2473 ITSAN1807-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH655 Resina toxicodendri 干漆 TCMH655
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH12 Artemisia argyi 艾叶 TCMH12 ITSAE2504-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ADRA1A, ADRA2A, AKR1B1, ALPL, APP, AXL, CA2, CA9, CES1, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MMP2, MMP9, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP1, TYR 11.3716
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.1761
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, FUT7, HTR2B, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 10.6058
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APP, CDC25B, CSNK2A1, CXCL8, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SLC6A4, SRC, TERT, XDH 10.3907
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, PTGS1, PTGS2 10.3837
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3837
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 9.38867
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 9.14487
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.12279
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, PPARA, PTGS2, RORC, SLC6A4, SRC, TYR 9.12279
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 8.98986
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 8.97071
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 8.97071
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, ESR1, HSD17B1, HSD17B2 8.81679
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 8.51689
[BP] GO:0010033 response to organic substance ADRA1A, ADRA2A, AKR1B1, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HTR5A, IGF1R, KDR, MMP2, PPARA, PTGS2, RORC, SLC6A4, SRC, TYR 8.50183
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, KCNH2, KDR, MET, PPARA, PTGS1, PTGS2, SLC6A2, SLC6A4, SRC, TERT, XDH 8.4334
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FLT3, HTR5A, PTGS2, RORC, SLC6A4, SRC, TYR 8.11311
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F10, F3, FABP4, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TOP1, TYR 8.06252
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 7.93376
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA6, CA9, CES1, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP1, TYR 7.86037
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP1, TYR, XDH 7.84618
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 7.83169
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, PTGS1, RORC 7.67853
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 7.67853
[BP] GO:0003018 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4, SRC 7.67853
[BP] GO:0009719 response to endogenous stimulus ADRA1A, ADRA2A, AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CXCL8, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HTR5A, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC 7.61652
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, HTR5A, PTGS2, RORC, SLC6A4, SRC, TYR 7.41256
[BP] GO:0097746 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 7.38506
[BP] GO:0035296 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 7.38506
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KCNH2, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TOP1 7.29715
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP1, TYR, XDH 7.27825
[BP] GO:0050880 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 7.14078
[BP] GO:0035150 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 7.11655
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 7.07714
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, FABP3, FABP4, FUT7, MET, PPARA, PTGS1, PTGS2 7.04004
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 6.92468
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CDC25B, CSNK2A1, DRD2, DRD3, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 6.87132
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.75826
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.75826
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 6.70624
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 6.70117
[BP] GO:0003013 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4, SRC 6.61536
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 6.58823
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 6.51524
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APP, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, HCAR2, HTR1A, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 6.50994
[BP] GO:0009725 response to hormone ADRA1A, ADRA2A, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HTR5A, PPARA, PTGS2, SLC6A4, SRC 6.43081
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 6.34025
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.2958
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 6.26607
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AXL, CYP1B1, DRD2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTGS2, PTPN1, SRC, XDH 6.26607
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 6.12038
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HTR2A, HTR2B, PPARA, PTGS2, RORC, SRC 6.10678
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, PTGS2, SLC6A4 6.01021
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, PTGS2, SLC6A4 6.01021
[BP] GO:0007187 None ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 5.97581
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AXL, CSNK2A1, CXCL8, CYP1B1, DRD2, DRD3, ESRRA, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 5.96285
[BP] GO:0032225 None DRD1, DRD2, DRD3, PTGS2, SLC6A4 5.96073
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 5.88924
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PTGS2, SRC, TERT 5.86087
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A, PTGS2, SLC6A4 5.72047
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, DRD1, DRD2, DRD3, HCAR2, HTR2A, HTR2B, KDR, PTGS2, SRC 5.71732
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 5.68523
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 5.68195
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.68195
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.68195
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 5.51147
[BP] GO:0007188 None ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.45783
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 5.38785
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, APP, AXL, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, PTGS2, RORC, SLC6A4, SRC, TERT 5.38684
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A 5.38684
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD17B1, HSD17B2, PTGS1, PTGS2, TYR, XDH 5.38535
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, KCNH2, MET, SRC, TERT 5.3847
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, ESR1, HTR7, PPARA, RORC, SLC6A4, SRC, TOP1 5.31326
[BP] GO:0007193 None ADORA1, ADRA2A, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.26738
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CDC25B, CES1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SIGMAR1, SLC6A4, SRC, TERT, TYR 5.23373
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, CXCL8, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 5.22793
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, PTGS2 5.15433
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, CXCL8, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 5.14754
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, CXCL8, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 5.12808
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.08866
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.07305
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, CXCL8, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 5.07305
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KCNH2, PPARA, SLC6A2, SLC6A4 5.05698
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, TOP1, TYR, XDH 5.05698
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.01264
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, HCAR2, HTR2B, KCNH2, MMP12, PTGS2, SLC6A4, SRC, TERT 4.97723
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, CXCL8, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.95585
[BP] GO:0007200 None ADRA1A, ADRA2A, DRD1, DRD2, ESR1, HTR2A, HTR2B 4.9176
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CES1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SLC6A4, SRC 4.80477
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, CXCL8, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.79065
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, HTR2A, HTR2B, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT, TYR 4.73562
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SIGMAR1, SRC, TERT, XDH 4.70596
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, DRD2, DRD3, HTR2A, KCNH2, MMP9, PTGS2 4.70596
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A, TYR 4.68598
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SIGMAR1, SRC, TERT, XDH 4.63663
[BP] GO:0045744 None ADRA2A, CXCL8, DRD2, DRD3, MET 4.58378
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRA2A, APP, AXL, CA2, CXCL8, CYP1B1, DRD2, DRD3, ESRRB, F3, HCAR2, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT 4.5767
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR1A, HTR2A, KCNH2, MMP9, PTGS2, SLC6A4 4.55158
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.5206
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRA2A, APP, CA2, CXCL8, DRD1, DRD2, DRD3, ESR1, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 4.50825
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC 4.50387
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 4.49879
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3 4.44418
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.42096
[BP] GO:0048878 chemical homeostasis ADRA1A, ADRA2A, AKR1B1, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B, KCNH2, MET 4.42096
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.40225
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 4.39972
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.34037
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 4.25695
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 4.24815
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, APP, AXL, CXCL8, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PTGS2, RORC, SLC6A4, SRC 4.24815
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, APP, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 4.20399
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, APP, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 4.20399
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRA2A, CXCL8, DRD1, DRD2, DRD3, HTR2B, HTR5A, KDR 4.12414
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SIGMAR1, SRC, TERT, XDH 4.12066
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.06299
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 4.06299
[BP] GO:0051952 None ADORA1, ADRA2A, DRD1, DRD2, DRD3, HTR2A 4.01447
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, PTGS2, SRC 3.98886
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, TYR 3.95262
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 3.9448
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 3.9441
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.93604
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.92918
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.9041
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A, PTGS2, SLC6A2, SLC6A4 3.86507
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.85223
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, APP, DRD2, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.82072
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.8165
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.8133
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.80935
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 3.79646
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.78986
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, APP, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.77029
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.76381
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.76375
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 3.75409
[BP] GO:0007623 circadian rhythm DRD2, DRD3, HTR7, PPARA, RORC, SLC6A4, TOP1 3.75409
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APP, AXL, CA1, CA2, CSNK2A1, CXCL8, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SRC 3.74054
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.74054
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, APP, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.73077
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AXL, CA2, CXCL8, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F3, HCAR2, HTR2A, HTR2B, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SLC6A4, SRC, TERT, XDH 3.69232
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.68433
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, CXCL8, CYP19A1, DRD1, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.66075
[BP] GO:0019933 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.62955
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.60798
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, APP, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.58711
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CXCL8, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, PTGS2, RORC, SLC6A4, SRC 3.58532
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AXL, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HTR5A, KDR, MMP9, PIM1, PPARA, PTGS2, RORC, SIGMAR1, SRC, TYR 3.58532
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT 3.57543
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, APP, CDC25B, DRD2, ESRRB, FLT3, HTR2A, HTR2B, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 3.5675
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F10, F3, MET, SRC, XDH 3.55304
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC, TYR 3.55213
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.54114
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, PPARA, PTGS1, PTGS2 3.53102
[BP] GO:0090066 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 3.52128
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRA2A, APP, AURKB, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 3.506
[BP] GO:0031623 None ACHE, CXCL8, DRD2, DRD3, HTR2B 3.48445
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC, TOP1 3.48445
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.48141
[BP] GO:0043266 None ADORA1, ADRA2A, DRD1, DRD2, HTR2A, KCNH2 3.47945
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP1B1, DRD2, DRD3, ESR1, ESR2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 3.45441
[BP] GO:0050801 ion homeostasis ADRA1A, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, HTR2A, HTR2B, KCNH2 3.45331
[BP] GO:0019935 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.43435
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CXCL8, CYP19A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, PTGS2 3.4272
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.42567
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.42567
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT 3.42263
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HCAR2, HTR2B, MMP12, SLC6A4, SRC 3.41416
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SLC6A4, SRC 3.37633
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, HCAR2, PTGS2 3.37277
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A, PTGS2 3.35987
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP1, TYR, XDH 3.35442
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, CXCL8, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.30935
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 3.28708
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.27027
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.25103
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TOP1 3.24044
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC, TYR 3.22241
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGS2, TERT 3.20084
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, APP, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 3.19066
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, APP, DRD2, FLT3, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 3.16185
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.14013
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.08563
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SLC6A4, SRC 3.06494
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.06418
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT 3.03782
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.03782
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PPARA, PTGS2, RORC, SRC, TERT 3.03573
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, APP, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 3.01241
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.009
[BP] GO:0003008 None ADORA1, ADRA1A, ADRA2A, AKR1B1, APP, CYP1B1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR7, KCNH2, PTGS2, SLC6A4, SRC, TYR 2.98601
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 2.97489
[BP] GO:0007189 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3 2.97489
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.97489
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, PTGS2, SLC6A4 2.95846
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, KCNH2 2.95764
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 2.95107
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 2.9437
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 2.9343
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, DRD1, DRD2, DRD3, F10, FABP3, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC6A2, SLC6A4, SRC, XDH 2.91606
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, DRD1, DRD2, DRD3, F10, FABP3, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, XDH 2.91158
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.91158
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A4 2.91158
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.91158
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP1, TYR, XDH 2.91158
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.88279
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.87152
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, DRD1, DRD2, DRD3, ESR1, F10, FABP3, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, XDH 2.8645
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, DRD3, HTR2A, PTGS2, SLC6A4 2.8645
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.8645
[BP] GO:0009115 None AOX1, XDH 2.8645
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, HTR2A, HTR2B, KDR, SRC 2.85271
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, HTR2A, HTR2B, KDR, PTPN1, SRC 2.84757
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.82642
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.82642
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.82642
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KCNH2, KDR, PTGS2, SRC 2.77198
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, SLC6A4, SRC, TERT 2.76016
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.76016
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, CXCL8, DRD1, ESR1, FLT3, IGF1R, MMP2, PTGS2, SLC6A4, SRC 2.74539
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRA2A, DRD2, HTR2A, KCNH2, PTGS2 2.74521
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CYP19A1, DRD2, ESR1, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.74101
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.74101
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.74101
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.74101
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.74037
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, ADRA2A, CXCL8, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.73977
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 2.72627
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.71959
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.6991
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.6991
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, DRD2, DRD3, HCAR2, HTR2B, MMP12, PTGS2, PTPN1, SRC 2.69011
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.68378
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, MET, MMP12, PPARA, PTGS2, RORC, SRC, TERT 2.68378
[BP] GO:0032845 None ADORA1, ADRA2A, DRD2, HTR2A, HTR2B, SRC 2.67205
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 2.67205
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.67205
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.67205
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.67205
[BP] GO:0051937 None DRD1, SLC6A2, SLC6A4 2.67205
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, CXCL8, CYP1B1, DRD2, FABP3, PTGS2, SLC6A4, TERT, XDH 2.6594
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.62393
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TOP1, XDH 2.61463
[BP] GO:0051588 None DRD1, DRD2, DRD3, HTR1A, SLC6A4 2.60329
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.5953
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.5953
[BP] GO:0016477 cell migration AXL, CXCL8, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.5944
[BP] GO:0050433 None ADRA2A, DRD2, DRD3, HTR2A 2.53655
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRA2A, AKR1B1, AXL, CXCL8, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MET, PTPN1, SRC 2.53655
[BP] GO:0045766 positive regulation of angiogenesis CXCL8, CYP1B1, F3, KDR, PTGS2, TERT 2.53327
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.52331
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.50786
[BP] GO:0043112 None ACHE, CXCL8, DRD2, DRD3, HTR2B 2.50661
[BP] GO:0050730 None ADORA1, ADRA2A, APP, FLT3, HTR2A, PTPN1, SRC 2.4908
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.47963
[BP] GO:0046110 None AOX1, XDH 2.47963
[BP] GO:0060160 None DRD2, DRD3 2.47963
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47963
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.47963
[BP] GO:0098657 import into cell ACHE, ADORA1, APP, AXL, CXCL8, DRD2, DRD3, HTR2B, SLC6A2, SLC6A4 2.46767
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA 2.46719
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.46234
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.46234
[BP] GO:0007611 None APP, DRD1, DRD2, DRD3, HTR2A, PTGS2, SLC6A4 2.46017
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 2.46017
[BP] GO:0055080 cation homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, KCNH2 2.45695
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRA2A, DRD2, DRD3, HCAR2, HTR2A, KCNH2, PTGS2 2.45561
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 2.44868
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.42329
[BP] GO:0006140 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA 2.39919
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.39919
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.39841
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TOP1, XDH 2.36828
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.3682
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TOP1 2.36267
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, ADRA2A, APP, AURKB, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, HTR2A, HTR2B, MET, MMP9, PTPN1, SRC, TERT, XDH 2.34477
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.34109
[BP] GO:0071880 None ADRA1A, ADRA2A, DRD2 2.34109
[BP] GO:0040011 locomotion AXL, CXCL8, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC 2.34059
[BP] GO:0007613 None DRD1, DRD2, HTR2A, PTGS2, SLC6A4 2.33837
[BP] GO:0007610 None APP, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, PPARA, PTGS2, SLC6A4 2.33213
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.30469
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, HTR2A, PTPN1, SRC 2.30355
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.28873
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.28873
[BP] GO:0015844 None DRD1, SLC6A2, SLC6A4 2.28873
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.28873
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.28775
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, MET, MMP9, PPARA, SRC, TERT 2.28775
[BP] GO:1904018 positive regulation of vasculature development CXCL8, CYP1B1, F3, KDR, PTGS2, TERT 2.28555
[BP] GO:0002793 None ACHE, ADORA1, DRD2, HCAR2, HTR2B, MMP12, SRC 2.27477
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ADRA2A, APP, CDC25B, CSNK2A1, DRD2, ESR1, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.27164
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PTGS1, PTGS2 2.26345
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.25351
[BP] GO:0048870 cell motility AXL, CXCL8, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.24676
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.24041
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.24041
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.24041
[BP] GO:0006145 None AOX1, XDH 2.23939
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.23939
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.23939
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, DRD2, DRD3, HCAR2, HTR2B, MMP12, SRC 2.23019
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.22761
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, HCAR2, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.21425
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, CYP19A1, DRD2, HCAR2, HTR1A, HTR2A 2.21304
[BP] GO:0010959 None ADORA1, ADRA2A, DRD1, DRD2, DRD3, HTR2A, KCNH2, PTGS2 2.20964
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2C19, CYP2D6 2.20865
[BP] GO:0019229 None ADRA1A, ADRA2A, HTR2A, PTGS2 2.20726
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.20726
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, HCAR2, HTR2B, MMP12, SLC6A4, SRC 2.20566
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.20346
[BP] GO:0051953 None ADORA1, ADRA2A, DRD2 2.20346
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.20346
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20346
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ADRA2A, APP, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.18964
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.18756
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP1, TYR, XDH 2.18378
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD17B2, MMP2, MMP9, PTGS2, SLC6A4, SRC 2.17847
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.17847
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.16429
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.15986
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.15757
[BP] GO:0071875 None ADRA1A, ADRA2A, DRD2 2.15757
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.15757
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.14691
[BP] GO:0023052 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, KCNH2, SLC6A2 2.13111
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.13111
[BP] GO:0090068 positive regulation of cell cycle process APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, TERT 2.12785
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, PTGS2 2.12114
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.12114
[BP] GO:0050927 None CXCL8, F3, KDR 2.11075
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.10289
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA2A, APP, CDC25B, DRD2, ESR1, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.10229
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, MMP12, PPARA, SIGMAR1, SLC6A2, SLC6A4 2.10118
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.10118
[BP] GO:0006940 None ADORA1, ADRA1A, ADRA2A, PTGS2 2.10118
[BP] GO:0006928 movement of cell or subcellular component ADRA2A, APP, AXL, CXCL8, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PTGS2, SRC 2.09912
[BP] GO:0050926 None CXCL8, F3, KDR 2.07213
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.07213
[BP] GO:0006693 None CES2, PTGS1, PTGS2 2.07213
[BP] GO:0006692 None CES2, PTGS1, PTGS2 2.07213
[BP] GO:0021853 None DRD1, DRD2 2.07213
[BP] GO:0010641 None F3, SRC 2.07213
[BP] GO:0007598 None F10, F3 2.07213
[BP] GO:1904936 None DRD1, DRD2 2.07213
[BP] GO:0042321 None ADORA1, DRD2 2.07213
[BP] GO:0090325 None DRD2, DRD3 2.07213
[BP] GO:0010513 None HTR2A, HTR2B 2.07213
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.06608
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.06608
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD17B1, HSD17B2 2.05378
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.05128
[BP] GO:0009416 response to light stimulus APP, AURKB, DRD1, DRD2, DRD3, PTGS2, TYR 2.05128
[BP] GO:0045913 None ESRRB, HTR2A, PPARA, SRC 2.04728
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.04728
[BP] GO:1904062 None ADRA2A, APP, DRD1, DRD2, DRD3, KCNH2, MMP9 2.0366
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.03327
[BP] GO:0008277 regulation of G-protein coupled receptor protein signaling pathway ADRA2A, CXCL8, DRD2, DRD3, MET 2.03071
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.03071
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, HTR2A, IGF1R, MET, MMP12, PPARA, PTPN1, RORC, SRC, TERT 2.01872
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.00535
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.00108
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, APP, DRD2, DRD3, HTR2A, KCNH2, MMP9, PTGS2 2.00108
[BP] GO:0007268 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, SLC6A2 2.00108
[BP] GO:0098916 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, SLC6A2 2.00108
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.00108
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.00108
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AXL, CA4, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC6A2, SLC6A4 6.75052
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AXL, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC6A2, SLC6A4 5.15924
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ADRA2A, APP, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PTGS2, SIGMAR1, SLC6A2, SLC6A4, SRC 4.74139
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT 4.32131
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, TYR 3.91274
[CC] GO:0044432 endoplasmic reticulum part APP, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, F10, FLT3, HSD17B2, PTGS1, PTGS2, PTPN1, SIGMAR1 3.90278
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC6A2, SLC6A4, SRC, TYR 3.79646
[CC] GO:0045121 membrane raft ADRA1A, APP, HTR2A, KDR, PTGS2, SLC6A2, SLC6A4, SRC 2.68166
[CC] GO:0005783 None ADORA1, APP, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, HTR5A, KDR, PTGS2, PTPN1, SIGMAR1, XDH 2.67205
[CC] GO:0098857 membrane microdomain ADRA1A, APP, HTR2A, KDR, PTGS2, SLC6A2, SLC6A4, SRC 2.67205
[CC] GO:0031233 None CA4, F10, F3 2.34109
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, HSD17B2, PTGS1, PTGS2, SIGMAR1 2.24319
[CC] GO:0098589 membrane region ADRA1A, APP, HTR2A, KDR, PTGS2, SLC6A2, SLC6A4, SRC 2.21474
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR2A, HTR5A, KCNH2, KDR, MMP2, MMP9, PIM1, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC6A4, SRC, TERT, TOP1, TYR, XDH 2.05378
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, ADRA2A, CA2, CA4, CA9, DRD1, DRD2, HTR2A, MET, PTGS2, SIGMAR1, SRC 2.04346
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 17.0157
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.5745
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP1, TYR, XDH 14.2466
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 12.1856
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3837
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, SLC6A4 9.15489
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 9.1484
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.12279
[MF] GO:0008227 None ADRA1A, ADRA2A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 8.78621
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 8.39661
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 8.17319
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.13023
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 8.09726
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 7.93031
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, F10, F3, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TOP1, TYR, XDH 7.93028
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TYR 7.67853
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, XDH 7.54917
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 7.42022
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 7.39287
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 7.10364
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, TYR 7.10364
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.84037
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.76748
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.76748
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.75826
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.75826
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6 6.70117
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.67499
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD17B1, HSD17B2, PTGS1, PTGS2, TYR, XDH 6.62015
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, SIGMAR1, SLC6A4, SRC, TOP1 6.10465
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.96285
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 5.91238
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD17B1, PTGS1, PTGS2, SRC, XDH 5.65104
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.65104
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 5.31326
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 5.31326
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.05473
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.05473
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.91292
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.60696
[MF] GO:1901338 None ADRA2A, DRD1, DRD2, DRD3 3.8133
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 3.75409
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 3.57543
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.5675
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 3.37567
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.26218
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.91158
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.8645
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.8645
[MF] GO:0008389 None CYP2A13, CYP2A6 2.8645
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP1, XDH 2.83825
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.82642
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.82642
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, PPARA, RORC 2.78165
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 2.77929
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, CSNK2A1, DRD2, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, PTGS2, SLC6A4, TERT, TYR, XDH 2.6885
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.63957
[MF] GO:0004935 None ADRA1A, ADRA2A, DRD2 2.5953
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.5218
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.5218
[MF] GO:0005330 None SLC6A2, SLC6A4 2.47963
[MF] GO:0047374 None CES1, CES2 2.47963
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.34109
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TOP1 2.32778
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.28873
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.23939
[MF] GO:0032795 None ADORA1, ADRA2A 2.23939
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.22459
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.07213
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.06608


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.8016
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR2B, HTR1A, HTR2A, PTGS2, HTR5A, CYP2C19, PTGS1, SLC6A4, HTR6, HTR7, CYP2D6, ALOX5 13.3707
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.9935
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR2B, HTR1A, HTR2A, HTR5A, ADRA1A, ADRA2A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3 8.5938
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 5.9731
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.5611
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP2C19, CYP19A1, PTGS1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 4.6893
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 5.0248
Bladder cancer_Homo sapiens_hsa05219 CXCL8, SRC, MMP1, MMP2, MMP9 5.0147
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A 4.0079
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.7937
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 3.8196
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP2C19 4.0079
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.8931
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.4443
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2A, DRD1, DRD2 3.6426
Pathways in cancer_Homo sapiens_hsa05200 CXCL8, FLT3, MMP1, MMP2, PTGS2, MMP9, MET, IGF1R 2.9559
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.7632
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2, PTGS1 3.277
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, CYP2C19, PTGS1 3.1246
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.5704
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 CXCL8, MMP2, PIM1, F3 2.3871
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.0647
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 2.1925
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.983
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 CXCL8, FLT3, MMP9, MET, IGF1R 2.3715
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.0968
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1A, ADRA2A 1.71
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.0367
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8598
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 CXCL8, SRC, MET 1.9161
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.5672
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.5057
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.3552
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CXCL8, CSNK2A1, PTGS2 1.601
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2054
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.3046
Hepatitis B_Homo sapiens_hsa05161 CXCL8, SRC, MMP9 1.2016
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 CXCL8, FLT3, KDR, MET 1.1979
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9069
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8645
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.7908
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.7908
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9069
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.0633
Rheumatoid arthritis_Homo sapiens_hsa05323 CXCL8, MMP1 0.9069
Platelet activation_Homo sapiens_hsa04611 SRC, PTGS1 0.7402
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7518
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1015
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.997
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7518
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.7459
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1979
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.7347
Hepatitis C_Homo sapiens_hsa05160 CXCL8, PPARA 0.6959
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.9948
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6786
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6786
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.5624
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.6786
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 CXCL8, PPARA 0.6519
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.631
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.631
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1793
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.5555
Malaria_Homo sapiens_hsa05144 CXCL8, MET 1.2847
Shigellosis_Homo sapiens_hsa05131 CXCL8, SRC 1.1176
Chemokine signaling pathway_Homo sapiens_hsa04062 CXCL8, SRC 0.5364
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.2847
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.1892
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1892
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.232
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2419
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2409
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2641
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2725
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2723
Influenza A_Homo sapiens_hsa05164 CXCL8 0.2725
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2801
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.3164
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.323
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3303
Phospholipase D signaling pathway_Homo sapiens_hsa04072 CXCL8 0.3218
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3266
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3342
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3507
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3507
Axon guidance_Homo sapiens_hsa04360 MET 0.3461
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.3548
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.3743
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.3569
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.3898
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 CXCL8 0.3867
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3927
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3927
Amoebiasis_Homo sapiens_hsa05146 CXCL8 0.3927
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4112
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4112
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.3957
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 CXCL8 0.3898
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3957
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4112
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.3927
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3957
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4112
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4112
Salmonella infection_Homo sapiens_hsa05132 CXCL8 0.4112
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.4112
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4112
Peroxisome_Homo sapiens_hsa04146 XDH 0.4112
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4112
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4333
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.434
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4408
Pertussis_Homo sapiens_hsa05133 CXCL8 0.4326
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4504
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4493
Glioma_Homo sapiens_hsa05214 IGF1R 0.4504
Bile secretion_Homo sapiens_hsa04976 CA2 0.44
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.4482
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5984
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 CXCL8 0.4408
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4504
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4617
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.6024
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4504
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5057
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 CXCL8 0.4765
Legionellosis_Homo sapiens_hsa05134 CXCL8 0.4853
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5672
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5007
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5364
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5336
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7747
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0147
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6664
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6786
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.6959
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6741
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.6876
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.8887
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1793


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)