TCM Prescription: Gu Zeng Sheng Zhen Tong Ointment



Prescription Description
Prescription IDTCMF3561
Pinyin NameGu Zeng Sheng Zhen Tong Gao
Chinese Name骨增生镇痛膏
English NameGu Zeng Sheng Zhen Tong Ointment
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH700 Drynaria fortunei 骨碎补 TCMH700 GBVM3977-11
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2693 Fructus gleditsiae abnormalis 猪牙皂 TCMH2693
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH296 Radix aconiti 川乌 TCMH296
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH1090 Brassica juncea 芥子 TCMH1090 ITSAJ4546-14
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH2094 Arisaema consanguineum 天南星 TCMH2094 GBVY604-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH27 Oleum eucalypti 按油 TCMH27
TCMH1063 Curcuma longa 姜黄 TCMH1063 ITSAP2805-14
TCMH2585 Cinnamomum camphora 樟脑 TCMH2585 SDH069-14
TCMH2329 Realgar 雄黄 TCMH2329
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT962 ENPP2 Autotaxin Hydrolase Q13822
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F2, F3, FABP3, FABP4, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MAOA, MET, MIF, POLA1, POLB, PPARA, PRKCD, SLC1A1, SMAD3, SRC, TEK, TERT, XDH 13.034
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.3015
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5686
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, POLB, PPARA, PRKCD, PTGES, SMAD3, SRC, TEK, TYR 11.5651
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, GPER1, GRIK5, GRM5, HSD17B2, IGF1R, INSR, MMP2, MMP9, POLB, PPARA, PRKCD, PTGES, SRC, TEK, TYR 11.5651
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, POLB, PPARA, PRKCD, PTGES, SMAD3, SRC, TEK, TERT, TYR 10.895
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PRKCD, SMAD3, SRC, TEK, TERT, XDH 10.4287
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, F2, F3, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP2, MMP9, NUAK1, PIM1, PTGES, SMAD3, SRC, TEK, TERT, XDH 10.4109
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F2, F3, FLT3, GPER1, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP9, PRKCD, SMAD3, SRC, TEK, TERT, XDH 10.3639
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F2, F3, FLT3, GPER1, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP9, PRKCD, SMAD3, SRC, TEK, TERT, XDH 10.3639
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.3639
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PRKCD, SMAD3, SRC, TEK, TERT, XDH 10.3639
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, GPER1, GRM5, IGF1R, INSR, KIT, MMP2, PPARA, PRKCD, SMAD3, SRC, TEK 10.3481
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, KIT, MET, MIF, PPARA, PTGES, TBXAS1 9.96788
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F2, F3, FLT3, GPER1, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PRKCD, SRC, TEK, XDH 9.28926
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, EGFR, ERBB2, F2, F3, FLT3, GPER1, GPR35, GRM1, HSPA1A, INSR, KDR, KIT, MET, MIF, SRC, TEK, XDH 8.75638
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, POLB, PPARA, SMAD3, SRC, TEK, TYR 8.58841
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, HSPA1A, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 8.58841
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 8.56549
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 8.49957
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F2, F3, FLT3, GPER1, GPR35, GRM1, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP9, PRKCD, SMAD3, SRC, TEK, TERT, XDH 8.49957
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 8.31544
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, INSR, MET, POLA1, POLB, SMAD3, SRC, TERT 8.10346
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PRKCD, SMAD3, SRC, TERT 7.97447
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, INSR, KIT, PPARA, PRKCD, SRC, TEK 7.86478
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.82725
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, APP, AR, BCL2, DUSP3, EGFR, ERBB2, ESRRB, F2, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PPARA, PRKCD, SMAD3, SRC, TEK, XDH 7.82061
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES, TBXAS1 7.82061
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GPER1, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PRKCD, SMAD3, SRC, TEK, TERT, XDH 7.79511
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, APP, AR, BCL2, DUSP3, EGFR, ERBB2, ESRRB, F2, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PPARA, PRKCD, SMAD3, SRC, TEK, XDH 7.77207
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GPER1, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 7.76955
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PRKCD, PTGES, SRC, TERT 7.66877
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES, TBXAS1 7.57314
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 7.29516
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT 7.26427
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT 7.26427
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, HSD11B1, HSD17B1, HSD17B2 7.25264
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 7.22132
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FLT3, KIT, MET, MIF, PIM1, POLA1, PRKCD, SRC, TEK, TYR 7.21439
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP2, MMP9, NUAK1, POLA1, POLB, PRKCD, SMAD3, SRC, TERT 7.21439
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, APP, AR, BCL2, EGFR, ERBB2, ESRRB, F2, FABP3, FLT3, GPER1, GRM1, GRM5, INSR, KDR, KIT, MIF, MMP9, PRKCD, SMAD3, SRC, TEK, XDH 7.21439
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, APP, AR, BCL2, EGFR, ERBB2, ESRRB, F2, FABP3, FLT3, GPER1, GRM1, GRM5, INSR, KDR, KIT, MIF, MMP9, PRKCD, SMAD3, SRC, TEK, XDH 7.21439
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F2, F3, GPER1, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PPARA, PRKCD, SMAD3, SRC, TEK, TERT 7.21439
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 7.21439
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, IGF1R, INSR, KDR, KIT, MMP2, PRKCD, SMAD3, SRC 7.11052
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 7.02516
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, PRKCD, PTGES, SMAD3, SRC, TEK, TERT, TYR 6.97131
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F2, F3, FABP4, FLT3, GPER1, GPR35, GRM1, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PRKCD, SMAD3, SRC, TEK, TERT, XDH 6.91967
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PPARA, PRKCD, SMAD3, SRC, TEK, TERT 6.9162
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 6.91237
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PRKCD, SMAD3, SRC, TEK, TERT 6.84357
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, SMAD3, SRC, TBXAS1, TEK, TERT, TYR, XDH 6.81067
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CSNK2A1, EGFR, ERBB2, ESR1, F2, F3, FLT3, GPER1, IGF1R, INSR, KDR, KIT, MIF, MMP2, MMP9, PIM1, TEK, TERT 6.71835
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SLC1A1, SMAD3, SRC, TEK, TERT, XDH 6.68257
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GPER1, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, SMAD3, SRC, TEK, TERT, XDH 6.68257
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, SMAD3, SRC, TEK, TERT 6.68257
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRB1, APP, AR, AURKB, BCL2, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, ESR1, ESR2, F2, F3, FABP4, FLT3, GPER1, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, KIT, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 6.64938
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRB1, APP, AR, AURKB, BCL2, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, GPER1, GRM1, GRM5, HSPA1A, INSR, KIT, MET, MIF, MMP9, PRKCD, SMAD3, SRC, TEK, TERT, XDH 6.64938
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, PTGES, SRC, TYR 6.63366
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, GPER1, PTGES, SRC, TEK, TYR 6.59207
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 6.57805
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PRKCD, PTGES, SMAD3, SRC, TEK 6.54639
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PRKCD, SMAD3, SRC, TEK 6.42655
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, APP, AR, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F2, F3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, KIT, MIF, MMP9, NUAK1, PRKCD, SMAD3, SRC, TEK, TERT, XDH 6.40189
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 6.26758
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP2, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, SMAD3, SRC, TBXAS1, TEK, TERT, TYR, XDH 6.24178
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES, TBXAS1 6.15165
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ERBB2, FABP3, FABP4, FUT7, KIT, MET, MIF, PPARA, PTGES, TBXAS1 6.14999
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 6.09611
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, BCL2, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F2, F3, FLT3, GPER1, GRM1, GRM5, HSPA1A, INSR, KDR, KIT, MIF, MMP9, PRKCD, SMAD3, SRC, TEK, XDH 6.09131
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, GPER1, INSR, KIT, MET, SRC, TEK, XDH 6.00129
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, BCL2, EGFR, ERBB2, ESRRB, F2, FLT3, GPER1, GRM1, GRM5, INSR, KDR, KIT, MIF, MMP9, PRKCD, SRC, TEK, XDH 5.9719
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 5.94989
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, BCL2, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F2, F3, FLT3, GPER1, GRM1, GRM5, HSPA1A, INSR, KDR, KIT, MIF, MMP9, PRKCD, SMAD3, SRC, TEK, XDH 5.9427
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, DUSP3, EGFR, ERBB2, FLT3, GPER1, GRM1, IGF1R, INSR, KDR, KIT, MIF, PRKCD, SRC, TEK, XDH 5.9193
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, APP, AR, AXL, BCL2, CA2, CACNA1C, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, F3, GPER1, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP9, PIM1, PRKCD, SLC1A1, SMAD3, SRC, TEK, TERT, XDH 5.81429
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F2, F3, FABP4, GPER1, GRM1, GRM5, GRM8, HSD17B2, IGF1R, INSR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, SMAD3, SRC, TEK, TYR 5.81184
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 5.78061
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, F2, F3, FABP4, GPER1, HSPA1A, IGF1R, MET, MIF, MMP2, NUAK1, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 5.71465
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, F2, FABP3, FABP4, GPER1, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3 5.61898
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, BCL2, EGFR, ERBB2, F2, FLT3, GPER1, GRM1, GRM5, INSR, KDR, KIT, MIF, MMP9, PRKCD, SRC, TEK, XDH 5.60742
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, APP, AR, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPER1, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 5.57914
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, SMAD3, SRC, TEK, TERT 5.57914
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA, PTGES, TBXAS1 5.57914
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, GPER1, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PRKCD, SMAD3, SRC, TEK, TERT, XDH 5.55919
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, EGFR, ERBB2, FLT3, GPER1, GRM1, INSR, KDR, KIT, MIF, SRC, TEK, XDH 5.55919
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.54896
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.54896
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, BCL2, DUSP3, EGFR, ERBB2, ESRRB, F2, FABP4, FLT3, GPER1, GRM1, GRM5, IGF1R, INSR, KDR, KIT, MIF, MMP9, PPARA, PRKCD, SRC, TEK, XDH 5.51386
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, DNMT1, EGFR, ERBB2, ESR1, FLT3, GPER1, GRM5, IGF1R, INSR, KIT, MMP2, PRKCD, SMAD3, SRC 5.51211
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 5.4077
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, BCL2, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, F2, FABP4, FLT3, GPER1, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PRKCD, SRC, TEK, XDH 5.39435
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, APP, AR, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, F2, F3, GPER1, HCAR2, HSPA1A, KDR, KIT, MET, MIF, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK, TERT 5.36806
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, AURKB, BCL2, EGFR, ERBB2, ESR1, F2, F3, FLT3, GPER1, GRM1, GRM5, HSPA1A, INSR, KIT, MIF, PRKCD, SMAD3, SRC, TEK, TERT, XDH 5.35163
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, BCL2, DNMT1, DYRK1A, EGFR, ERBB2, F2, FLT3, GPER1, GRM1, GRM5, INSR, KDR, KIT, MIF, MMP9, PRKCD, SRC, TEK, XDH 5.28698
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRB1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, GPER1, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, NUAK1, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 5.27078
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, GRM1, HSPA1A, KIT, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TERT, TYR 5.25577
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 5.24017
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, APP, AR, AURKB, BCL2, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GPER1, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 5.21243
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.20502
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, INSR, KIT, MET, SRC, TEK 5.19263
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, MMP9, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.1429
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, PRKCD, SRC, TEK 5.127
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.06911
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PIM1, POLB, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, TYR 5.06911
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 5.04297
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, BCL2, CYP19A1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F2, GPER1, HSPA1A, IGF1R, MET, MIF, MMP9, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 5.03314
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, F2, GPER1, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, INSR, MIF, MMP9, PPARA, PRKCD, SMAD3, SRC, TERT 5.0226
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, ERBB2, FLT3, GRM1, IGF1R, INSR, KIT, MIF, PRKCD, SRC 5.02033
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, F2, GPER1, PPARA, PRKCD, SMAD3, TEK 5.00166
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, BCL2, DUSP3, EGFR, ERBB2, F2, FABP4, FLT3, GPER1, GRM1, GRM5, IGF1R, INSR, KDR, KIT, MIF, MMP9, PRKCD, SRC, TEK, XDH 4.99296
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, DNMT1, EGFR, ESR1, GPER1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PRKCD, SRC 4.97916
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPER1, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PPARA, PRKCD, PTGES, SMAD3, SRC, TEK, TERT, XDH 4.9227
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, SMAD3, SRC, TERT, XDH 4.89807
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.88426
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, ERBB2, F2, GPER1, HCAR2, INSR, MIF, PRKCD, SMAD3, SRC, TERT 4.88408
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, SMAD3, SRC, TERT, XDH 4.88267
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, GPER1, HCAR2, HSD11B1, HSD17B1, HSD17B2 4.83328
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5, MIF, PRKCD 4.80608
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, KIT, PPARA, PRKCD, SRC, TEK 4.80446
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, APP, AR, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GPER1, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 4.78158
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, F2, FABP3, FLT3, GPER1, HCAR2, KIT, PPARA, PRKCD, SRC, TEK 4.75297
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PIM1, PPARA, SRC 4.74275
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPER1, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 4.69745
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, MAOA, TBXAS1, TYR, XDH 4.6696
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, ERBB2, F2, PPARA, SMAD3 4.66674
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, SRC 4.63905
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 4.55002
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPER1, GPR35, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PPARA, PRKCD, PTGES, SMAD3, SRC, TEK, TERT, XDH 4.54288
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGES, TERT 4.41597
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 4.37403
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, EGFR, F2, GPER1, HCAR2, KDR, MIF, SRC 4.37403
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, GPER1, KDR, KIT, TEK 4.34055
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 4.33132
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.30986
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DUSP3, EGFR, ERBB2, F2, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KIT, MIF, PRKCD, SRC, TEK 4.30986
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, DNMT1, ESR1, GPER1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PRKCD, SMAD3, SRC, TEK 4.29138
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TERT, TYR, XDH 4.28349
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, KIT, SRC, TEK 4.27848
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.27848
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DNMT1, EGFR, FABP3, FLT3, GPER1, GRM5, IGF1R, INSR, MMP2, PPARA, PRKCD, SRC, TEK, TYR 4.25267
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, F2, FABP3, GPER1, GPR35, GRM1, GRM5, SMAD3 4.22667
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TERT 4.21909
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, SRC, TEK 4.1707
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, F2, GPER1, KDR, SRC 4.1707
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CA3, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 4.15569
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TERT 4.15569
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, F2, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 4.14644
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling F2, FLT3, GPER1, KDR, KIT, TEK 4.13273
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CA3, CSNK2A1, DUSP3, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PRKCD, SRC, TEK, XDH 4.09038
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GPER1, GRM5, IGF1R, INSR, PPARA, PRKCD, SRC, TEK 4.09038
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.07956
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.07956
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, ESR1, GPER1, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, SRC, XDH 4.0212
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CACNA1C, F2, GPER1, GPR35, GRM5, MIF, MMP9, PRKCD 3.99928
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, AR, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F2, F3, FABP4, FLT3, GPER1, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PRKCD, SMAD3, SRC, TEK, XDH 3.99583
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, F2, GPER1, HSPA1A, KIT, MIF, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, PRKCD, PTGES, SMAD3, SRC, TEK, TERT 3.97388
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DUSP3, EGFR, ERBB2, F2, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KIT, MIF, PRKCD, SRC, TEK 3.96635
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, PRKCD, SRC, TEK 3.9327
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TERT 3.9327
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, SRC 3.90223
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DNMT1, EGFR, FABP3, FLT3, GPER1, GRM5, IGF1R, INSR, MMP2, PPARA, PRKCD, SRC, TEK, TYR 3.86738
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, F2, INSR, PRKCD, SMAD3, XDH 3.86738
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, KIT, MIF, PRKCD, SRC 3.83825
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, F2, GPER1, PPARA, PRKCD, SMAD3, TEK 3.833
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 3.82985
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 3.7803
[BP] GO:0033674 positive regulation of kinase activity ADORA1, EGFR, ERBB2, F2, FLT3, GRM1, GRM5, INSR, KIT, MIF, PRKCD, SRC, TEK 3.77292
[BP] GO:0035556 intracellular signal transduction ADRB1, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DNMT1, EGFR, ERBB2, GPER1, GRM5, IGF1R, INSR, KDR, KIT, MET, MIF, NUAK1, POLB, PRKCD, SRC, TEK 3.76033
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CA3, CSNK2A1, DUSP3, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PRKCD, SRC, TEK, XDH 3.75873
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, F2, GPER1, GPR35, GRM1, GRM5, SMAD3 3.7581
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, GPER1, PPARA, PRKCD, SMAD3, TEK 3.69139
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, GPER1, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PPARA, PRKCD, SMAD3, SRC, TERT, XDH 3.67203
[BP] GO:0009968 negative regulation of signal transduction AR, BCL2, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, SMAD3, SRC, TERT, XDH 3.67203
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, EGFR, GPER1, GRM5, IGF1R, INSR, MMP2, PRKCD, SRC 3.62228
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA, PTGES, TBXAS1 3.6186
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, F2, PRKCD, SMAD3, SRC, TERT 3.59193
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.58838
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CYP1A1, CYP1B1, KDR, POLB, PRKCD, SRC 3.55841
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.53172
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GPER1, GRIK5, INSR, MAOA, SLC1A1, SMAD3 3.52212
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.47367
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, F2, F3, FABP4, GPER1, KDR, MET, MIF, PPARA, PRKCD, SMAD3, TEK 3.47367
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 3.46804
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, EGFR, ERBB2, F2, FLT3, GRM1, GRM5, INSR, KIT, MIF, PRKCD, SRC, TEK 3.4635
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, DUSP3, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KIT, MIF, PRKCD, SRC 3.43894
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, ERBB2, FLT3, GRM1, IGF1R, INSR, KIT, MIF, PRKCD, SRC 3.42845
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, INSR, PRKCD, SMAD3, XDH 3.4269
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, CACNA1C, EGFR, ESR1, F2, GPER1, GPR35, GRM1, GRM5, SMAD3 3.42111
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, INSR, KIT, MIF, SRC 3.42111
[BP] GO:0010676 None ESRRB, GPER1, INSR, PPARA, SRC 3.40365
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, KIT, SRC, TEK 3.40365
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.40305
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.39345
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CYP1B1, ERBB2, FABP3, GPER1, HSPA1A, PTGES, SMAD3, TERT, XDH 3.36059
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, KIT, SRC 3.35922
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, EGFR, ERBB2, F2, GPER1, HCAR2, MIF, PRKCD, SMAD3, SRC 3.3485
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, EGFR, GPER1, GRM5, IGF1R, INSR, MMP2, PRKCD, SRC 3.34475
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, CACNA1C, EGFR, GPER1, GPR35, GRM1, HCAR2, KIT, SLC1A1, SMAD3 3.31943
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, AR, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F2, F3, FABP4, FLT3, GPER1, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PRKCD, SMAD3, SRC, TEK, XDH 3.3176
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, ERBB2, GPER1, KDR, MIF, SRC, TEK 3.3176
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, SRC 3.30246
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GPER1, GRM5, IGF1R, INSR, PRKCD, SRC 3.28808
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.28148
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.26979
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, F2, GPER1, MIF, PPARA, PRKCD, SMAD3, TEK 3.26241
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, EGFR, HSPA1A, MAOA 3.257
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, GPER1, MMP9 3.23208
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.23208
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PRKCD, SRC 3.23208
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, SMAD3, SRC, TBXAS1, TEK, TERT, TYR, XDH 3.23208
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, EGFR, ESR1, F2, GPER1, GPR35, GRM1, GRM5, SMAD3 3.21818
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, KIT, PPARA, SRC 3.2147
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, POLB, PRKCD, SRC 3.17001
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 3.16563
[BP] GO:0007188 None ADORA1, ADRB1, GPER1, GRM1, GRM3, GRM5, GRM8 3.15433
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, EGFR, FLT3, GPER1, SRC 3.14985
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.12236
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CYP1A1, DUSP3, EGFR, GPER1, INSR, MIF, SRC, TERT 3.12236
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP2, MMP9, SRC, XDH 3.11904
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.11386
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.06053
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.06053
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.06053
[BP] GO:0040008 regulation of growth ADRB1, APP, AR, BCL2, CSNK2A1, EGFR, ERBB2, ESR2, F2, HSPA1A, INSR, PIM1, SMAD3 3.06053
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, F2, GPER1, GPR35, GRIK5, GRM1, GRM5, SMAD3 3.06053
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.05067
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.04523
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, F2, GPER1, GPR35, GRM1, GRM5, SMAD3 3.03873
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, GPER1, HSPA1A, MIF, MMP9, PRKCD, SMAD3, SRC, TERT 3.03873
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, F2, GPER1, GPR35, GRM1, GRM5, SMAD3 2.98836
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, POLB, TEK, TYR 2.98708
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, ERBB2, F2, GPER1, HCAR2, MIF, PRKCD, SMAD3, SRC 2.93019
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, F2, GPER1, GPR35, GRM1, GRM5, SMAD3 2.93002
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.93002
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.93002
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 2.92699
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.91333
[BP] GO:0045913 None ESRRB, GPER1, INSR, PPARA, SRC 2.91109
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, F2, GPER1, GPR35, GRM1, GRM5, SMAD3 2.89777
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, CACNA1C, ESR1, F2, GPER1, GPR35, GRM1, GRM5, SMAD3 2.89531
[BP] GO:0019725 cellular homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, F2, GPER1, GPR35, GRIK5, GRM1, GRM5, POLA1, SMAD3 2.89013
[BP] GO:0050793 regulation of developmental process ADRB1, APP, AR, AXL, BCL2, CA2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, F3, GPER1, INSR, KDR, KIT, MIF, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TERT, XDH 2.88829
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, GPER1, HSPA1A, MMP2, PPARA, PRKCD, SMAD3, SRC, TEK 2.88682
[BP] GO:1903829 positive regulation of cellular protein localization APP, BCL2, EGFR, ERBB2, F2, GPER1, PRKCD, SMAD3, SRC, TERT 2.88267
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.88267
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, GPER1, KDR, KIT, TEK, TERT 2.87973
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, SMAD3, SRC, TBXAS1, TEK, TERT, TYR, XDH 2.86014
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 2.85099
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, SRC 2.83929
[BP] GO:0009115 None AOX1, XDH 2.82436
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRB1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 2.81208
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CACNA1C, CSNK2A1, EGFR, ERBB2, F2, GPER1, HCAR2, MIF, PRKCD, SMAD3, SRC, TERT 2.80893
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, GPER1 2.80893
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, F2, FABP4, GPER1, GRM3, GRM8, HSPA1A, IGF1R, MET, MIF, MMP9, PPARA, PRKCD, SMAD3, SRC, TERT, XDH 2.80809
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DUSP3, ERBB2, ESR1, ESRRA, F2, GPER1, HCAR2, HSPA1A, KIT, MIF, MMP2, PRKCD, SMAD3, SRC 2.79857
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, SRC 2.78902
[BP] GO:0007187 None ADORA1, ADRB1, GPER1, GRM1, GRM3, GRM5, GRM8 2.77504
[BP] GO:0051128 regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, ERBB2, ESR1, ESR2, F2, GPER1, GRIK5, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PRKCD, SMAD3, SRC, TEK 2.77102
[BP] GO:0071383 None AR, EGFR, FLT3, GPER1, SRC 2.76735
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, EGFR, ERBB2, F2, GPER1, HCAR2, MIF, PRKCD, SMAD3, SRC 2.76664
[BP] GO:1901342 regulation of vasculature development CYP1B1, ERBB2, F3, GPER1, KDR, KIT, TEK, TERT, XDH 2.76664
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, GPER1, IGF1R, INSR, KDR, MET, PPARA, PRKCD, SMAD3, SRC, TERT 2.76624
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRB1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 2.7556
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 2.74579
[BP] GO:1903827 regulation of cellular protein localization APP, AR, BCL2, CSNK2A1, EGFR, ERBB2, F2, GPER1, PRKCD, SMAD3, SRC, TERT 2.74579
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.74317
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.72749
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.72749
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, KIT, MIF, PRKCD, SRC 2.72749
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.7031
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3, KIT 2.7031
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DNMT1, GPER1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.7031
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, GPER1, MMP2, MMP9, TERT 2.70192
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation GPER1, MMP2, MMP9, TERT 2.68064
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, SRC 2.68064
[BP] GO:0032870 cellular response to hormone stimulus AR, EGFR, ESR1, FLT3, GPER1, INSR, KIT, PRKCD, SRC 2.66896
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.65883
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3, KIT 2.65881
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, APP, AR, AURKB, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, IGF1R, INSR, MET, PPARA, PRKCD, SMAD3, SRC, TERT 2.6067
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, EGFR, GPER1, KDR, MIF, SRC, TEK 2.60508
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, F2, FLT3, FUT7, HSPA1A, KIT, MIF, MMP9, PRKCD, SMAD3, SRC 2.60508
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, INSR, KIT, MIF, SRC 2.60014
[BP] GO:0034762 None ABCB1, APP, BCL2, CA2, CACNA1C, F2, GPER1, GPR35, GRM5, MMP9 2.60014
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.5637
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F2, F3, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PRKCD, SMAD3, SRC, TEK, TYR, XDH 2.5628
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, SLC1A1, SMAD3, SRC, TEK, TERT, XDH 2.54911
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 2.53948
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.53039
[BP] GO:0055065 metal ion homeostasis APP, BCL2, CACNA1C, EGFR, ESR1, F2, GPER1, GPR35, GRM1, GRM5, SMAD3 2.5249
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F2, F3, FABP4, KDR, MET, MIF, SMAD3 2.51468
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, DYRK1A, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, PRKCD, TERT, XDH 2.50521
[BP] GO:0042058 None ADORA1, APP, EGFR, GPER1, MMP9 2.50148
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, GPER1, MMP9, SMAD3, SRC, XDH 2.50104
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.50104
[BP] GO:0070920 None EGFR, ESR1, TERT 2.50104
[BP] GO:0007154 None ADORA1, ADRB1, AR, AXL, BCL2, CACNA1C, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 2.49945
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F2, F3, GPER1, INSR, KDR, KIT, PIM1, SMAD3, SRC, TEK, TERT, XDH 2.48745
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRB1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCD, SMAD3, SRC, TEK, TERT, XDH 2.46703
[BP] GO:0051480 regulation of cytosolic calcium ion concentration CACNA1C, ESR1, F2, GPER1, GPR35, GRM1, GRM5, SMAD3 2.46142
[BP] GO:0051172 None APP, AR, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, GPER1, GRM3, GRM8, HSPA1A, IGF1R, MIF, MMP9, PPARA, PRKCD, SMAD3, SRC, TERT, XDH 2.44764
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MIF, MMP9, SRC, TERT 2.44557
[BP] GO:0060341 regulation of cellular localization APP, AR, BCL2, CACNA1C, CSNK2A1, EGFR, ERBB2, F2, GPER1, GRIK5, PRKCD, SMAD3, SRC, TERT 2.43362
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.43362
[BP] GO:0099566 None GRM1, GRM5 2.43362
[BP] GO:0046110 None AOX1, XDH 2.43362
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43362
[BP] GO:0002520 None CACNA1C, SMAD3 2.43362
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PRKCD, SRC 2.43105
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, GPER1, INSR, KDR, KIT, PIM1, SMAD3, SRC, TEK, TERT 2.37054
[BP] GO:2000351 None GPER1, KDR, TEK, TERT 2.33712
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, F2, PRKCD, SMAD3, SRC, TERT 2.33501
[BP] GO:0051093 None ADRB1, APP, BCL2, EGFR, ERBB2, ESRRB, F2, GPER1, MIF, PPARA, SMAD3, TEK, TERT, XDH 2.3286
[BP] GO:1905475 None AR, BCL2, CSNK2A1, EGFR, ERBB2, GPER1 2.32668
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, SRC 2.32544
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, KIT, PIM1 2.31329
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, GPER1, SRC 2.30208
[BP] GO:0003018 None ADORA1, ADRB1, EGFR, GPER1, SRC, TEK 2.30208
[BP] GO:2001236 regulation of extrinsic apoptotic signaling pathway AR, BCL2, GPER1, HSPA1A, SRC, TERT 2.30208
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.30194
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, CACNA1C, ESR1, F2, GPER1, GPR35, GRM1, GRM5, SMAD3 2.29442
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, F2, GPER1, HCAR2 2.28841
[BP] GO:0042307 positive regulation of protein import into nucleus APP, EGFR, F2, PRKCD, SMAD3 2.27423
[BP] GO:0050994 None ADORA1, HCAR2, PPARA, PRKCD 2.25374
[BP] GO:0023052 None ADORA1, ADRB1, AR, CACNA1C, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 2.25177
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.23898
[BP] GO:1904591 positive regulation of protein import APP, EGFR, F2, PRKCD, SMAD3 2.23898
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.23898
[BP] GO:0007568 aging AURKB, BCL2, CYP1A1, MIF, POLB, PRKCD, TERT 2.23874
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.22374
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.22374
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.22374
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.22374
[BP] GO:1900542 None ADRB1, ESRRB, GPER1, GRM3, GRM8, INSR, PPARA 2.20913
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.20558
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.20394
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.20394
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, GPER1, MMP9, SMAD3, SRC, XDH 2.1917
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.1917
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, HSPA1A, SRC, TERT 2.1917
[BP] GO:0070201 None ACHE, APP, BCL2, CACNA1C, EGFR, ERBB2, F2, GPER1, HCAR2, MIF, PRKCD, SMAD3, SRC 2.18881
[BP] GO:0051336 regulation of hydrolase activity ADRB1, APP, CSNK2A1, EGFR, ERBB2, ESR1, F3, GPER1, HSPA1A, KIT, MMP9, NUAK1, PRKCD, SMAD3, SRC, XDH 2.18458
[BP] GO:0006145 None AOX1, XDH 2.18458
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.18458
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, AXL, BCL2, CA2, CA9, CACNA1C, CYP1B1, EGFR, ESR1, INSR, MET, MMP2, POLB, SMAD3, SRC, TEK 2.18078
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GPER1, GRIK5, HCAR2, MMP9, PRKCD, SMAD3, SRC, XDH 2.18078
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 2.16356
[BP] GO:0006140 None ADRB1, ESRRB, GPER1, GRM3, GRM8, INSR, PPARA 2.15006
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GPER1, GRIK5, HCAR2, MMP9, PRKCD, SMAD3, SRC, XDH 2.14804
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, MAOA, TYR 2.14804
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, F2, FUT7, KDR, KIT, MIF, MMP1, MMP9, PRKCD, SRC, TEK 2.14804
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.14804
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.14804
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.14804
[BP] GO:0032409 None ABCB1, APP, BCL2, GPR35, GRM5, MMP9, PRKCD 2.1458
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.13692
[BP] GO:0050866 negative regulation of cell activation AXL, DUSP3, ERBB2, F2, GPER1, PRKCD 2.13104
[BP] GO:0008406 gonad development BCL2, CYP19A1, ESR1, INSR, KIT 2.11943
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, ERBB2, INSR, KDR, SMAD3, SRC 2.11891
[BP] GO:0050678 None AR, EGFR, ERBB2, F3, KDR, SMAD3, TEK, XDH 2.10323
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 2.10076
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.10033
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, KIT, MIF, SRC 2.09921
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, APP, AR, AXL, BCL2, CYP1A1, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, KIT, MET, MIF, MMP2, MMP9, PRKCD, SMAD3, SRC, TEK, TERT 2.09041
[BP] GO:0007267 None ADORA1, ADRB1, AR, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 2.08743
[BP] GO:0051345 None ADRB1, APP, EGFR, ERBB2, ESR1, F3, GPER1, HSPA1A, KIT, PRKCD, SMAD3, XDH 2.07794
[BP] GO:0050679 None AR, EGFR, ERBB2, F3, KDR, TEK 2.07678
[BP] GO:0035295 tube development AKR1B1, AR, CYP1A1, EGFR, KIT, SMAD3 2.07678
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, MMP2, MMP9, SRC 2.06842
[BP] GO:0051894 None KDR, SMAD3, TEK 2.05318
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.05318
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD 2.04311
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, SRC 2.04311
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, APP, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, INSR, MET, PPARA, PRKCD, SMAD3, SRC, TERT 2.04311
[BP] GO:0045927 positive regulation of growth BCL2, CSNK2A1, EGFR, ERBB2, F2, INSR, PIM1 2.03189
[BP] GO:0002793 None ACHE, ADORA1, EGFR, GPER1, HCAR2, MIF, SRC 2.03189
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, MAOA 2.03189
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 2.03189
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, F2, GPER1, KIT, MIF, POLB, PTGES 2.01925
[BP] GO:0044419 interspecies interaction between organisms AXL, DYRK1A, EGFR, F2, HSPA1A, INSR, KDR, MET, MMP1, POLA1, SMAD3, SRC 2.01312
[BP] GO:0050927 None F3, KDR, SMAD3 2.01101
[BP] GO:0048169 None APP, GRM5, KIT 2.01101
[BP] GO:0010641 None F3, SRC 2.01032
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.01032
[BP] GO:0007423 None BCL2, CACNA1C, CYP1A1, EGFR, KIT 2.00477
[BP] GO:0050920 regulation of chemotaxis CYP19A1, F3, KDR, MET, MIF, SMAD3 2.00461
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, ESR1, F2, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, MMP2, PIM1, PRKCD, SLC1A1, SMAD3, SRC, TEK, TERT 5.78638
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRB1, APP, AXL, BACE1, CA2, CA4, CA9, CACNA1C, DUSP3, EGFR, ERBB2, F2, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, SLC1A1, SRC, TEK 5.51198
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, EGFR, ERBB2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK 5.4137
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX5, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ERBB2, ESR1, F2, F3, FLT3, FUT7, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP2, PIM1, PRKCD, PTGES, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TERT, TYR 4.94108
[CC] GO:0042734 None GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.26735
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ERBB2, ESR1, F2, F3, FLT3, FUT7, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, KIT, MAOA, MET, PTGES, SLC1A1, SRC, TBXAS1, TEK, TYR 4.15754
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, BACE1, CA4, F3, FLT3, GPER1, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 4.01521
[CC] GO:0043235 receptor complex APP, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.57743
[CC] GO:0014069 None ADORA1, CACNA1C, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC 3.41853
[CC] GO:0099572 None ADORA1, CACNA1C, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC 3.41853
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GPER1, GRIA4, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MIF, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, SHBG, SLC1A1, SMAD3, SRC, TERT, TYR, XDH 3.39759
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.32959
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, BACE1, FLT3, GPER1, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 3.24955
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, F2, FLT3, GPER1, GRIA2, HSD11B1, HSD17B2, PTGES, TBXAS1 3.21818
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GPER1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MIF, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, SHBG, SLC1A1, SMAD3, SRC, TERT, TYR, XDH 2.89531
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 2.81992
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, GPER1, GRIA2, HSD11B1, HSD17B2, PTGES, TBXAS1 2.7863
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2, TEK 2.74278
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, EGFR, F3, MET, MIF, TEK 2.54174
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APP, CA4, EGFR, ERBB2, GPER1, HSPA1A, PRKCD, PTGES, SRC, TYR 2.52217
[CC] GO:0097060 None GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.44357
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, BACE1, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ERBB2, ESR1, ESR2, F2, FABP3, FABP4, FLT3, FUT7, GPER1, GRIA2, GRIA4, GRIK5, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MAOA, MIF, MMP2, MMP9, PIM1, POLA1, PRKCD, PTGES, SMAD3, SRC, TBXAS1, TERT, TYR, XDH 2.32054
[CC] GO:0031982 None ABCB1, ADRB1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AXL, BACE1, CA1, CA2, CA4, CA6, DUSP3, EGFR, F2, F3, FABP3, FABP4, GPER1, GRIA4, GRM5, HSPA1A, INSR, KDR, KIT, MIF, MMP9, PRKCD, SHBG, SLC1A1, SRC, TYR 2.11891
[CC] GO:0031224 None ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AXL, BACE1, CA12, CA14, CA4, CA9, CACNA1C, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GPER1, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, KIT, MAOA, MET, PTGES, SLC1A1, TBXAS1, TEK, TYR 2.03189
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.4011
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, TBXAS1, TYR, XDH 16.1983
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TERT, TYR, XDH 11.9185
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 11.5651
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5651
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, F2, F3, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PRKCD, PTGES, SRC, TBXAS1, TEK, TERT, TYR, XDH 11.5651
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, TEK 10.1838
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 9.54971
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, TEK 8.85937
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 8.62623
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, SMAD3, TEK 8.58841
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, TEK 8.58841
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.58841
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.85683
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.78054
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 7.54739
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F2, KIT, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, SLC1A1, SMAD3, TBXAS1, TERT, TYR, XDH 7.37127
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, SMAD3 7.26427
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F2, KIT, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, SLC1A1, SMAD3, TBXAS1, TERT, TYR, XDH 7.21439
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, XDH 7.09771
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, INSR, KDR, KIT 7.07036
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, TYR 6.72282
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.63366
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, TEK 6.25957
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, KIT, MET, TEK 6.25957
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA 6.15643
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA 6.15643
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, GPER1, HSD17B1, IGF1R, INSR, SHBG 5.87236
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, SHBG 5.83582
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, MAOA, TBXAS1, TYR, XDH 5.8294
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 5.74369
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC, TBXAS1 5.74369
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA 5.65862
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PPARA, PRKCD, SRC, TEK 5.58056
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC, TBXAS1 5.51211
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, POLB, PRKCD, SRC, TEK, TERT 5.20855
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, TYR 5.127
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, POLA1, PTGES, SRC, TBXAS1, XDH 5.06911
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.0226
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 4.7591
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 4.26735
[MF] GO:0019899 enzyme binding ADRB1, APP, AR, AURKB, BACE1, BCL2, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRB, F3, GRM5, HSPA1A, KIT, MET, MIF, POLA1, POLB, PPARA, PRKCD, SMAD3, SRC, TEK 4.25791
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.22582
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 3.976
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, INSR, KDR, KIT, SMAD3 3.76033
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, GPER1, HSD17B1, PPARA, SHBG 3.52057
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, HSD17B2, XDH 3.47455
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, PRKCD, SLC1A1, SRC, TEK, XDH 3.43121
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, FLT3, GRIK5, IGF1R, KDR, KIT, MET, MIF, MMP9, SMAD3, TERT, TYR, XDH 3.3754
[MF] GO:0043168 anion binding ABCB1, AOX1, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, PTGES, SLC1A1, SRC, TEK, XDH 3.01481
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PRKCD 2.93002
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.82436
[MF] GO:0008389 None CYP2A13, CYP2A6 2.82436
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, PRKCD, SRC, TEK, XDH 2.74229
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, PRKCD, SRC, TEK, XDH 2.74017
[MF] GO:0019838 growth factor binding EGFR, ERBB2, IGF1R, INSR, KDR, TEK 2.66896
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 2.53859
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.50104
[MF] GO:0099583 None GRM1, GRM5 2.43362
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 2.43105
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 2.3939
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.30194
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.30194
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ADRB1, AOX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, SHBG, SMAD3, SRC, TBXAS1, TEK, TERT, XDH 2.27942
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.24028
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, MET, PPARA, SMAD3 2.1917
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.18458
[MF] GO:0004971 None GRIA2, GRIA4 2.18458
[MF] GO:0005497 None AR, SHBG 2.18458
[MF] GO:0051425 None APP, INSR 2.18458
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, SHBG, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TERT, TYR, XDH 2.17135
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, PRKCD, SRC, TEK 2.12405
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.11943
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.10351
[MF] GO:0001540 amyloid-beta binding ACHE, BACE1, GRIA2, INSR 2.06718
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, SMAD3, SRC 2.01925
[MF] GO:0043559 insulin binding IGF1R, INSR 2.01032


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.7129
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, GPER1, PRKCD, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 8.6548
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.4494
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 7.0725
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, ERBB2, MET, EGFR, IGF1R 7.1646
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, GPR35, ADORA3, GRIK5, GRM8, ADORA1, ADRB1, F2, GRM1, GRIA4 6.869
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.7066
Pathways in cancer_Homo sapiens_hsa05200 AR, SMAD3, FLT3, MMP1, MMP2, KIT, ERBB2, BCL2, MMP9, MET, EGFR, IGF1R 5.3751
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.1923
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.1059
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.2401
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, MAOA, AKR1B1, TYR, CYP19A1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 5.0863
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, ADRB1, MET, EGFR, IGF1R, HSPA1A 4.5236
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 4.2854
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PRKCD, BCL2, PIM1, F3 4.2129
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, KIT, GRM8, GRM1, EGFR 4.3656
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.9027
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.6388
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, ERBB2, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR 4.1598
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, ERBB2, BCL2, TEK, EGFR, IGF1R 4.1859
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, ADRB1, CACNA1C, PPARA, GRIA4 3.6194
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, MET, EGFR, IGF1R 3.5952
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, ERBB2, MET, EGFR 3.9743
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2, AOX1 3.9307
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 3.3372
Prostate cancer_Homo sapiens_hsa05215 AR, ERBB2, BCL2, EGFR, IGF1R 3.4799
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCD, CACNA1C, EGFR 3.4489
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KIT, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.0798
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, ADRB1, GRM1, EGFR 3.4877
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, GRM1, GRIA4 3.2621
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, ERBB2, ADRB1, CACNA1C, GRM1, EGFR 3.068
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, CYP2D6, ALOX5, CACNA1C 3.0798
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.8139
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, ADRB1 3.1774
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRB1, CACNA1C 2.3761
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, CACNA1C, GRIA4 2.9492
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF, TYR 3.8668
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 2.963
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.9767
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, CACNA1C, GRIA4 1.9863
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9112
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 1.8533
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.6602
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5845
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.0567
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.0027
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9686
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.8665
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.6602
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, CACNA1C 1.4269
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8576
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, ERBB2, EGFR 1.9393
Insulin resistance_Homo sapiens_hsa04931 INSR, PRKCD, PPARA 1.4371
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.5845
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 1.9686
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.3653
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9112
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGES 1.9863
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, CACNA1C, EGFR, HSPA1A 1.1785
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.3525
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, PRKCD, CACNA1C 2.252
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCD 1.2109
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.2048
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.1759
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA 2.2362
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1311
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.1311
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP, CACNA1C 1.0728
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 0.9241
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2, EGFR 0.8834
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2314
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2404
Alcoholism_Homo sapiens_hsa05034 MAOA 0.2471
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.251
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2878
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3, TERT 0.745
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.3124
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3124
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3208
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD, BCL2 0.7632
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7555
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7632
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7632
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6012
Axon guidance_Homo sapiens_hsa04360 MET 0.3354
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.5847
Oocyte meiosis_Homo sapiens_hsa04114 AR, IGF1R 0.7537
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.3404
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCD, CACNA1C 0.7632
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.752
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.5133
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCD 0.8834
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.7174
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6643
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7256
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6946
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.8761
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 0.9666
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.584
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.9314
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.9094
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3773
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.9314
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC, PRKCD 0.5653
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 0.9285
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9285
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9129
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3908
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.403
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.3902
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.398
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.398
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0045
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4083
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCD 0.4129
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4074
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4176
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.4198
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 0.9996
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4288
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4198
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4275
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4187
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4262
Peroxisome_Homo sapiens_hsa04146 XDH 0.43
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4329
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.1311
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4566
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.43
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.0728
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4435
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1613
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4451
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4566
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.2048
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4678
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.2434
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4566
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.1538
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4864
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1768
Shigellosis_Homo sapiens_hsa05131 SRC 0.4889
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.4889
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.253
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5426
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.331
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5727
Malaria_Homo sapiens_hsa05144 MET 0.5772
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.584
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5819
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4269
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5988
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.5935
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6358
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6191
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6684
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6295
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4943
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5845
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.743
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.706
DNA replication_Homo sapiens_hsa03030 POLA1 0.6643
Base excision repair_Homo sapiens_hsa03410 POLB 0.6882
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7256
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7256
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7467
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8228
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.743
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7632
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 1.9991
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.919
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9296
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2048


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)