TCM Prescription: Gu Tong Yao Wine



Prescription Description
Prescription IDTCMF3522
Pinyin NameGu Tong Yao Jiu
Chinese Name骨痛药酒
English NameGu Tong Yao Wine
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病,未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH1791 Loranthus parasiticus 桑寄生 TCMH1791
TCMH1651 Radix schefflerae arboricolae 七叶莲 TCMH1651
TCMH2166 Clematis chinensis 威灵仙 TCMH2166
TCMH921 Polygonum cuspidatum 虎杖 TCMH921 ITSAI2369-14
TCMH1376 Trachelospermum jasminoides 络石藤 TCMH1376 ITSAJ4261-14
TCMH37 Smilax china 菝葜 TCMH37 CPBOL4044-11
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH2522 NA 油松节 TCMH2522
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH385 Sargentodoxa cuneata 大血藤 TCMH385 ITSAG360-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1086 Sambucus williamsii 接骨木 TCMH1086 ITSAL4612-14
TCMH1889 Lycopodium japonicum 伸筋草 TCMH1889 KX302823
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH2267 Periploca sepium 香加皮 TCMH2267 ITSAJ4400-14, GBVP4570-15
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH2334 Dipsacus japonicus 续断 TCMH2334 ITSAC1509-14
TCMH1059 Glycine max TCMH1059 ITSAJ4675-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, F2, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD17B1, HSD17B2, KCNH2, KDR, MET, MIF, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 12.7194
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.1837
[BP] GO:0042221 response to chemical ABCG2, ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCHE, BCL2, CA2, CA3, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 12.0917
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCHE, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 11.759
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5503
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCHE, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 11.0177
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FUT7, GLO1, MIF, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 9.25354
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 8.65755
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1, TRPV1 8.56144
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CA2, CA3, CA6, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, IGF1R, KCNH2, KDR, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1, TYR 8.37753
[BP] GO:0030168 platelet activation ADRA2A, AXL, F2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 8.19609
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, SLC6A4, SRC, TRPV1 8.19609
[BP] GO:0042493 response to drug ABCG2, AKR1B1, APEX1, AXL, BCHE, BCL2, CA3, CA9, CYP1A1, CYP1B1, FABP3, KCNH2, KDR, POLB, PRKCD, PRKCE, PRKCG, PTGS2, SLC6A2, SLC6A4, SRC, TRPV1 8.19609
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, ADRA2A, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, ESR1, F2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, KCNH2, MET, PIK3CA, PIK3CB, POLA1, POLB, PRKCB, PRKCE, SRC, TERT, TRPV1 8.19609
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GRIK5, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 7.80239
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GRIK5, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 7.73313
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, PRKCE, PRKCG, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 7.49816
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF, PTGS1, PTGS2, TBXAS1 7.49483
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SLC6A4, SRC, TRPV1 7.49483
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KCNH2, KDR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SRC, TERT, TRPV1 7.39782
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GRIK5, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 7.27239
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, PRKCB, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC6A2, SLC6A4, TRPV1 7.25792
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF, PTGS1, PTGS2, TBXAS1 7.24714
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 7.05922
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KCNH2, KDR, MIF, MMP2, MMP9, PIK3CA, POLA1, POLB, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1 6.9898
[BP] GO:0006805 xenobiotic metabolic process BCHE, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, NQO2, PTGS1, RORC 6.88407
[BP] GO:0033993 response to lipid ALPL, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PRKCE, PTGS2, RORC, SLC6A4, SRC, TYR 6.82529
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC6A4, SRC, TBXAS1, TERT, TOP2A, TYR, XDH 6.77888
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC6A4, SRC, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 6.77888
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SRC, TRPV1 6.50345
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, XDH 6.48046
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, XDH 6.44732
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT 6.35893
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT 6.30569
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CES1, CYP1A1, CYP1B1, KDR, POLB, PRKCD, PRKCE, SLC6A4, SRC 6.30569
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.10552
[BP] GO:0015872 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 6.07835
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, GRIK5, GRM1, GRM5, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 6.04373
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PPARA, PTGS1, PTGS2, TBXAS1 6.04373
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, BCHE, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, F2, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS1, PTGS2, SLC6A4, SRC, TERT, XDH 5.97934
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, BCHE, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCE, PTGS2, SLC6A4 5.97934
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, BCHE, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCE, PTGS2, SLC6A4 5.97934
[BP] GO:0015893 None ABCG2, CA2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4 5.95202
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SRC, TRPV1 5.84172
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF, PTGS1, PTGS2, TBXAS1 5.77204
[BP] GO:0048878 chemical homeostasis ABCG2, ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, ESR1, F2, FABP3, FABP4, GRIK5, GRM1, GRM5, KCNH2, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, TRPV1 5.75798
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT 5.74369
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.72924
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, FUT7, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 5.61931
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC, TERT 5.60991
[BP] GO:0051937 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 5.60812
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2, TBXAS1 5.57657
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, F2, FLT3, GRM1, KDR, MET, MIF, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, XDH 5.55186
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, ESRRB, F2, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 5.47061
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, F2, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, XDH 5.46433
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, GRIK5, GRM5, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SLC6A4, SRC, TERT, TRPV1 5.44938
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, BCL2, CDC25B, ESRRB, F2, FABP3, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 5.39724
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, BCL2, CDC25B, ESRRB, F2, FABP3, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 5.39724
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SRC, TERT 5.26252
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC1A1, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 5.24506
[BP] GO:0006855 None ABCG2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 5.1313
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 5.12913
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, F2, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 5.12869
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 5.07153
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, HSD17B1, HSD17B2 5.03678
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GRM3, GRM8, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 4.97495
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CA7, CYP19A1, F2, GRIK5, GRM5, KCNH2, MIF, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SLC6A4, SRC, TERT, TRPV1 4.96433
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, BCL2, CDC25B, ESRRB, F2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.96433
[BP] GO:0015844 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 4.93151
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, BCHE, CYP1B1, GRIK5, PTGS2, SLC1A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, TRPV1 4.92931
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, BCL2, CDC25B, ESRRB, F2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.91586
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SRC, TERT 4.86968
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.81255
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, F2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TRPV1 4.75456
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SRC, TERT 4.75372
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, F2, KDR, MIF, PIK3CB, PRKCE, PTGS2, SRC, TRPV1 4.75372
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, MIF, PPARA, PTGS1, PTGS2, TBXAS1 4.71811
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F2, FABP4, FLT3, GRM1, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TERT, XDH 4.71811
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.63794
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F2, FLT3, GRM1, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.63794
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCHE, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F2, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TRPV1, TYR 4.63043
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KCNH2, KDR, PRKCD, PRKCE, PTGS2, SRC, TRPV1 4.56322
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, BCHE, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SLC6A4, SRC, TRPV1, TYR 4.50676
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, SRC 4.50676
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1, XDH 4.47002
[BP] GO:0001775 cell activation ADRA2A, ALOX5, AXL, BCL2, F2, FLT3, FUT7, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TRPV1 4.47002
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, ESRRB, F2, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.45699
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.43259
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, F2, FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC 4.40624
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, ESR1, F2, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TERT 4.31482
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 4.24007
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 4.24007
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, F2, MIF, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1 4.21555
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8, PTGS2 4.13533
[BP] GO:0015874 None SLC22A1, SLC22A2, SLC6A2 4.13022
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.13022
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, BCHE, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SLC6A4, SRC, TRPV1, TYR 4.11279
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.1013
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 4.09013
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.08454
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1, XDH 4.07909
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 4.04156
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CA2, CA9, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCD, PTGS2, RORC, SLC6A4, SRC, TERT, TOP2A, TYR 4.03971
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2, TBXAS1 4.03548
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.0281
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, F2, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.98187
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, F2, KDR, PRKCE, SRC, TRPV1 3.89567
[BP] GO:0050801 ion homeostasis ABCG2, BCL2, CA12, CA2, CA7, ESR1, F2, FABP3, GRM1, GRM5, KCNH2, PIK3CB, PRKCB, PRKCE, TRPV1 3.87821
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CYP19A1, F2, KCNH2, MIF, MMP12, PRKCD, PRKCE, PTGS2, SLC6A4, SRC, TERT, TRPV1 3.86507
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CA3, CYP1B1, MMP9, PRKCD, PTGS1, PTGS2, SRC 3.85525
[BP] GO:0051234 None ABCG2, ACHE, ADORA1, ADRA2A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, F2, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 3.84007
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.84007
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.84007
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, SRC 3.84007
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC, TRPV1 3.7715
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, PRKCA, PRKCE, SLC22A1 3.76975
[BP] GO:0001504 None SLC1A1, SLC22A3, SLC6A2, SLC6A4 3.76858
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 3.76307
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, PRKCG, RORC, SLC6A4, SRC, TOP2A 3.73692
[BP] GO:0019725 cellular homeostasis ABCG2, APEX1, BCL2, CA2, CA7, ESR1, F2, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, POLA1, PRKCB, PRKCE, TRPV1 3.73505
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, BCL2, CDC25B, F2, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.71973
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 3.70545
[BP] GO:0006810 None ABCG2, ACHE, ADORA1, ADRA2A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, F2, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TRPV1, XDH 3.69607
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GRM3, GRM8, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 3.69607
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.69607
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 3.69607
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3, SLC6A4 3.68756
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, BCL2, CA2, CA7, F2, GRM5, KCNH2, MIF, MMP9, PRKCD, PRKCE, PTGS2, SLC6A4 3.68644
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, GRM1, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SRC, TERT, TRPV1, TYR 3.6673
[BP] GO:0007193 None ADORA1, ADRA2A, GRM1, GRM3, GRM5, GRM8 3.59682
[BP] GO:0050730 None ADORA1, ADRA2A, FLT3, GRM5, MIF, PRKCD, PRKCE, PTPN1, SRC 3.58848
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, MIF, POLB, PRKCD, PTGS2, TERT 3.58848
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.58168
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.57328
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, PRKCD, SRC 3.54767
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.53154
[BP] GO:0051179 None ABCG2, ACHE, ADORA1, ADRA2A, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, F2, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 3.4906
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 3.48012
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, F2, FLT3, GRM1, GRM5, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.47972
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.46256
[BP] GO:0098771 inorganic ion homeostasis ABCG2, BCL2, CA12, CA2, CA7, ESR1, F2, GRM1, GRM5, KCNH2, PIK3CB, PRKCB, PRKCE, TRPV1 3.45065
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 3.44741
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.44741
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF, PRKCD 3.44345
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 3.40019
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.40008
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, BCHE, BCL2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 3.39212
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.39212
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.38939
[BP] GO:0055082 cellular chemical homeostasis ABCG2, BCL2, CA2, CA7, ESR1, F2, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, PRKCB, PRKCE, TRPV1 3.38607
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, BCHE, BCL2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 3.38286
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, MIF, PIK3CB, PIM1, POLA1, PRKCD, SRC, TYR 3.38286
[BP] GO:0001101 response to acid chemical AKR1B1, BCHE, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SLC6A4, SRC 3.34383
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 3.33307
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 3.32395
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PIK3CA, POLB, PPARA, SRC, TYR 3.32201
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.24061
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, PRKCG, SRC 3.23014
[BP] GO:0050994 None ADORA1, ADRA2A, PPARA, PRKCD, PRKCE 3.22971
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F2, FLT3, IGF1R, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A 3.22769
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 3.20032
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, KCNH2, MMP9, PRKCE, PTGS2 3.1989
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, ESR1, FLT3, GRM5, IGF1R, MMP2, PRKCD, PRKCE, PTGS2, SLC6A4, SRC, TRPV1 3.1989
[BP] GO:0015696 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 3.1989
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC6A2, SLC6A4, SRC, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 3.1989
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, F2, FLT3, GRM1, GRM5, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.18868
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, GRM1, IGF1R, MIF, PIK3CB, PRKCD, PTPN1, SRC 3.16719
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, ESR1, F2, FABP4, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TERT, XDH 3.15666
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, F2, FABP4, GRM3, GRM8, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 3.15326
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, MIF, PRKCE, SRC, TRPV1 3.15326
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SRC, TRPV1 3.15307
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 3.14121
[BP] GO:0006693 None CES2, MIF, PTGS1, PTGS2 3.13988
[BP] GO:0006692 None CES2, MIF, PTGS1, PTGS2 3.13988
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, FLT3, GRM1, KDR, MIF, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, XDH 3.13383
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TERT 3.133
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, FLT3, GRM1, GRM5, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.11202
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, F2, FABP4, GRM3, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 3.10771
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GRM5, IGF1R, PPARA, PRKCD, PTGS2, SRC, TRPV1 3.10099
[BP] GO:0071702 None ABCG2, ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, MMP12, PPARA, PRKCB, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC6A2, SLC6A4, TRPV1 3.06474
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, AURKB, BCL2, CDC25B, ESR1, ESR2, F2, FLT3, GRM1, GRM5, MET, MIF, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TERT, XDH 3.05865
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, BCL2, CSNK2A1, ESRRB, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1 3.05865
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, F2, MIF, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2, TRPV1 3.05865
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, ESR1, F2, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.05322
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.02894
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, FLT3, GRM1, IGF1R, KDR, MIF, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 3.00744
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 3.001
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, BCL2, CDC25B, F2, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 2.96919
[BP] GO:0055080 cation homeostasis ABCG2, BCL2, CA2, CA7, ESR1, F2, GRM1, GRM5, KCNH2, PIK3CB, PRKCB, PRKCE, TRPV1 2.95927
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 2.95841
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 2.92968
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, GRM5, IGF1R, KCNH2, KDR, MET, MIF, PIK3CA, PIK3CB, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC 2.92968
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, AXL, BCL2, CA2, CYP1B1, ESR1, ESRRA, ESRRB, F2, GRM1, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SLC1A1, SLC6A4, SRC, TERT, TRPV1, XDH 2.91938
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, ESR1, F2, FLT3, GRM1, GRM5, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 2.91938
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, MIF, PRKCA, PRKCE, SLC6A4, SRC, TERT 2.91162
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, AXL, BCL2, CA2, CYP1B1, ESRRB, F2, KDR, MET, MIF, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SLC1A1, SRC, TERT, TRPV1 2.90994
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.89845
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 2.88726
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, BCHE, PTGS2, SLC6A4 2.88151
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, F2, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TRPV1, XDH 2.8729
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F2, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, XDH 2.86364
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, CDC25B, F2, FABP4, FLT3, GRM1, GRM5, IGF1R, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.86261
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, PRKCE 2.83573
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 2.82185
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.82128
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 2.79868
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, BCL2, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 2.79406
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, F2, PRKCD, PTGS2, TRPV1, XDH 2.79271
[BP] GO:0030003 cellular cation homeostasis ABCG2, BCL2, CA2, CA7, ESR1, F2, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, TRPV1 2.76223
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.7442
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, GRM5, MIF, PTPN1, SRC 2.7336
[BP] GO:0035408 None PRKCA, PRKCB 2.73325
[BP] GO:0009115 None AOX1, XDH 2.73325
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.73325
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.72791
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, GRM5, IGF1R, MMP2, PRKCD, PTGS2, SLC6A4, SRC, TRPV1 2.72791
[BP] GO:1900543 None ADRA2A, GRM3, GRM8, PPARA, PRKCA 2.7038
[BP] GO:0042391 None ADORA1, BCL2, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC, TRPV1 2.68441
[BP] GO:0006873 cellular ion homeostasis ABCG2, BCL2, CA2, CA7, ESR1, F2, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, TRPV1 2.68363
[BP] GO:0040017 positive regulation of locomotion ADRA2A, BCL2, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 2.68363
[BP] GO:0045980 None ADRA2A, GRM3, GRM8, PPARA, PRKCA 2.68173
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.68173
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, ESR1, F2, FABP4, KDR, MET, MIF, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2 2.6702
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, BCL2, CYP19A1, ESR1, ESR2, F2, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SRC, TERT, XDH 2.64246
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, FABP4, FLT3, GRM1, GRM5, IGF1R, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.63985
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.63812
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.63812
[BP] GO:0001516 None MIF, PTGS1, PTGS2 2.63812
[BP] GO:0046457 None MIF, PTGS1, PTGS2 2.63812
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, MIF, PTGS1, PTGS2 2.63665
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, F2, FABP4, FLT3, GRM1, GRM5, IGF1R, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.61052
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.59427
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.58808
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 2.57983
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.54492
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 2.53915
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 2.53915
[BP] GO:0015850 None ABCG2, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 2.52952
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MIF, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 2.48892
[BP] GO:0007584 response to nutrient ALPL, BCHE, CYP1A1, PTGS2, SLC6A4, TRPV1, TYR 2.48759
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, GRM1, MIF, PIK3CB, PTPN1, SRC 2.48175
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, GRM5, IGF1R, MMP2, PRKCD, PTGS2, SLC6A4, SRC, TRPV1 2.47749
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, SRC 2.47749
[BP] GO:0006836 None SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 2.46489
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, PTGS2, TYR 2.44955
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCHE, BCL2, CYP1A1, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.44955
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, AURKB, BCL2, CDC25B, ESR1, F2, FLT3, GRM1, GRM5, MIF, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SRC, TERT, XDH 2.42904
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC 2.40948
[BP] GO:0061098 None ADORA1, ADRA2A, GRM5, PTPN1 2.40948
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.38958
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.38958
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 2.38668
[BP] GO:0030818 None ADRA2A, GRM3, GRM8, PRKCA 2.37631
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.36989
[BP] GO:0099566 None GRM1, GRM5 2.34761
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.34761
[BP] GO:0046110 None AOX1, XDH 2.34761
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.34761
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.34761
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 2.3436
[BP] GO:0042133 neurotransmitter metabolic process ACHE, BCHE, CYP1B1, SLC22A2, SLC6A4 2.34016
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.33697
[BP] GO:0055065 metal ion homeostasis ABCG2, BCL2, ESR1, F2, GRM1, GRM5, KCNH2, PIK3CB, PRKCB, PRKCE, TRPV1 2.33697
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 2.3366
[BP] GO:0051172 None ADRA2A, APEX1, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, F2, FABP4, GRM3, GRM8, IGF1R, MIF, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 2.33425
[BP] GO:0042136 neurotransmitter biosynthetic process ACHE, CYP1B1, SLC22A2, SLC6A4 2.33238
[BP] GO:0030803 None ADRA2A, GRM3, GRM8, PRKCA 2.33238
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process F2, PRKCD, PTGS2, TRPV1, XDH 2.30822
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC, TERT 2.30646
[BP] GO:0007154 None ADORA1, AXL, BCL2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, PTGS2, SLC1A1, SLC6A2, TRPV1 2.27829
[BP] GO:0030815 None ADRA2A, GRM3, GRM8, PRKCA 2.27119
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.26258
[BP] GO:0007268 None GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1, SLC6A2 2.24676
[BP] GO:0098916 None GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1, SLC6A2 2.24676
[BP] GO:1900372 None ADRA2A, GRM3, GRM8, PRKCA 2.24286
[BP] GO:0030809 None ADRA2A, GRM3, GRM8, PRKCA 2.24286
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.24286
[BP] GO:0048545 response to steroid hormone ALPL, BCHE, BCL2, CA2, FLT3, PTGS2, SRC 2.21966
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.21639
[BP] GO:0030800 None ADRA2A, GRM3, GRM8, PRKCA 2.21405
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, ESR1, F2, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, TRPV1 2.2065
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, MIF, MMP12, PRKCE, SLC6A4, SRC, TRPV1 2.19904
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, KDR, PRKCA, PRKCB, PTGS2, TERT 2.19154
[BP] GO:0099536 None GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1, SLC6A2 2.19059
[BP] GO:0099537 None GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1, SLC6A2 2.19059
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 2.18342
[BP] GO:0031960 response to corticosteroid ALPL, BCHE, BCL2, FLT3, PTGS2, SRC 2.18063
[BP] GO:0031329 regulation of cellular catabolic process ADRA2A, APEX1, BCL2, ESRRB, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 2.17117
[BP] GO:0007188 None ADORA1, ADRA2A, GRM1, GRM3, GRM5, GRM8 2.16867
[BP] GO:0042752 None ADORA1, PPARA, PRKCG, RORC, TOP2A 2.16614
[BP] GO:0010676 None ESRRB, PPARA, PRKCE, SRC 2.16283
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, F2, FABP4, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 2.15701
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 2.14609
[BP] GO:0006875 cellular metal ion homeostasis ABCG2, BCL2, ESR1, F2, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, TRPV1 2.12877
[BP] GO:0055074 calcium ion homeostasis BCL2, ESR1, F2, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, TRPV1 2.12723
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.12165
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, MIF, MMP9, POLA1, POLB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1 2.1183
[BP] GO:1901374 None SLC22A1, SLC22A2 2.1183
[BP] GO:0006145 None AOX1, XDH 2.1183
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.1183
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.11619
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CYP19A1, ESR1, ESRRA, F2, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC 2.114
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.10288
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, ESR1, F2, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, TRPV1 2.09887
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, F2, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 2.08362
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, GRM1, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.07728
[BP] GO:0071456 cellular response to hypoxia BCL2, PRKCE, PTGS2, SRC, TERT 2.07041
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.06457
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.06457
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.06457
[BP] GO:0031667 response to nutrient levels ALPL, BCHE, BCL2, CYP1A1, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.05093
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, CA2, F2, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 2.05093
[BP] GO:0043270 None ADORA1, ADRA2A, F2, KCNH2, MIF, PRKCD, SLC6A4 2.04845
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.04184
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2, TERT 2.04184
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, FLT3, GRM1, IGF1R, MIF, PIK3CB, PRKCD, PTPN1, SRC 2.03026
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.02588
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F2, FLT3, GRM1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, XDH 2.01929
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.01768
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.01768
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, GRIK5, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 2.00748
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F2, FABP4, FLT3, GRM1, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TERT, XDH 2.00661
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, F2, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TERT, TRPV1 6.19901
[CC] GO:0098590 plasma membrane region ABCG2, ADORA1, ADRA2A, CA2, CA4, CA9, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PRKCG, PTGS2, SLC1A1, SLC22A1, SRC, TRPV1 4.93151
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ALOX5, ALPL, AXL, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, F2, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TBXAS1, TERT, TRPV1, TYR 4.13022
[CC] GO:0044459 plasma membrane part ABCG2, ADORA1, ADORA3, ADRA2A, AXL, CA2, CA4, CA9, F2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, PRKCG, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, SRC, TRPV1 3.45065
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, CA4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, TRPV1 3.14177
[CC] GO:0044456 None ACHE, ADORA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, SLC22A2, SLC6A4, SRC, TRPV1 3.13988
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, TRPV1 2.96919
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 2.92968
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CES1, CES2, CYP19A1, FLT3, GRIK5, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 2.92785
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, TRPV1 2.92487
[CC] GO:0044425 membrane part ABCG2, ACHE, ADORA1, ADORA3, ADRA2A, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, F2, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, IGF1R, KCNH2, KDR, MET, MPEG1, PIK3CA, PIK3CB, PRKCG, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, SRC, TBXAS1, TRPV1, TYR 2.66146
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BCHE, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, F2, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HSD17B1, HSD17B2, KCNH2, KDR, MIF, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC6A4, SRC, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 2.46241
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 2.42952
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 2.42952
[CC] GO:0043227 membrane-bounded organelle ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM5, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, NQO2, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A2, SLC47A1, SRC, TERT, TOP2A, TYR, XDH 2.33697
[CC] GO:0043005 None ADORA1, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PRKCG, PTGS2, SLC6A2, SLC6A4, SRC 2.12877
[CC] GO:0044432 endoplasmic reticulum part BCHE, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, F2, FLT3, GRIA2, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 2.04845
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.184
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, TBXAS1, TYR, XDH 17.5452
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 12.6463
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 11.8301
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, F2, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TERT, TOP2A, TYR, XDH 11.352
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.352
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, BCHE, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 11.0757
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC 10.7733
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 10.1926
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 9.35976
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 7.87072
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.49483
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 6.77888
[MF] GO:0015238 None ABCG2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4 6.38896
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC6A4, SRC, TOP2A, TRPV1 5.54984
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.47264
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2, SRC, TBXAS1 5.4014
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 5.38467
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2, SRC, TBXAS1 5.14944
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, PPARA, RORC, TRPV1 5.05149
[MF] GO:0042802 identical protein binding ABCG2, ACHE, ADRA2A, AOX1, BCHE, BCL2, CSNK2A1, ESR1, ESR2, FLT3, GRIK5, IGF1R, KCNH2, KDR, MET, MIF, MMP9, NQO2, PTGS2, SLC22A1, SLC6A4, TERT, TOP2A, TRPV1, TYR, XDH 4.93151
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2, TBXAS1, TYR 4.7958
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TERT 4.74162
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TBXAS1, XDH 4.70742
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 4.68577
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.63794
[MF] GO:0005333 None SLC22A1, SLC22A2, SLC6A2 4.63782
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.56212
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.56212
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB, PRKCD 4.47988
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.34548
[MF] GO:0008519 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 4.24007
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, PPARA, RORC, TRPV1 4.24007
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TBXAS1, TYR 4.137
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.13533
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.13022
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, PPARA, PRKCE, RORC, TRPV1 4.08544
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, PPARA, RORC, TRPV1 4.04156
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.89485
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.48744
[MF] GO:1901618 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 3.48744
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 3.34383
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, BCHE, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2C19, ESR1, ESR2, ESRRB, GRM5, KCNH2, MET, MIF, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SLC6A4, SRC, TOP2A 3.34383
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.31603
[MF] GO:0005326 None SLC1A1, SLC22A1, SLC22A2, SLC6A2, SLC6A4 3.16633
[MF] GO:0042803 protein homodimerization activity ABCG2, ACHE, ADRA2A, AOX1, BCL2, FLT3, KCNH2, NQO2, PTGS2, SLC22A1, SLC6A4, TERT, TOP2A, TYR, XDH 3.14121
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.13988
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.05865
[MF] GO:0036094 small molecule binding ABCG2, ADORA1, AOX1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TOP2A, TRPV1, XDH 2.94082
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 2.92968
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.88726
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, KCNH2, TRPV1 2.85506
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.82185
[MF] GO:0008324 None GRIA2, GRIA4, GRIK5, KCNH2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, TRPV1 2.77254
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.73325
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.73325
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 2.73325
[MF] GO:0035403 None PRKCA, PRKCB 2.73325
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 2.72791
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.72791
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 2.63985
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 2.62458
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.51523
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 2.42024
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.37631
[MF] GO:0015307 None SLC47A1, SLC47A2 2.34761
[MF] GO:1901375 None SLC22A1, SLC22A2 2.34761
[MF] GO:0005330 None SLC6A2, SLC6A4 2.34761
[MF] GO:0005277 None SLC22A1, SLC22A2 2.34761
[MF] GO:0099583 None GRM1, GRM5 2.34761
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.34761
[MF] GO:0008513 None SLC22A1, SLC22A2 2.34761
[MF] GO:0004699 None PRKCD, PRKCE 2.34761
[MF] GO:0047374 None CES1, CES2 2.34761
[MF] GO:0052689 carboxylic ester hydrolase activity ACHE, BCHE, CA1, CA2, CES1, CES2 2.34562
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.33697
[MF] GO:0000166 nucleotide binding ABCG2, AOX1, AURKB, AXL, CSNK2A1, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 2.32947
[MF] GO:1901265 nucleoside phosphate binding ABCG2, AOX1, AURKB, AXL, CSNK2A1, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 2.32864
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, BCHE, CA1, CA2, CA3, CDC25B, CES1, CES2, POLA1, PTPN1 2.30919
[MF] GO:0022804 None ABCG2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4 2.30231
[MF] GO:0005524 ATP binding ABCG2, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.27364
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.27119
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.21639
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.21639
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HSD17B1, PPARA, RORC, TRPV1 2.17362
[MF] GO:0032559 adenyl ribonucleotide binding ABCG2, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.16695
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.16316
[MF] GO:0046983 protein dimerization activity ABCG2, ACHE, ADORA1, ADRA2A, AOX1, AXL, BCL2, FLT3, KCNH2, NQO2, PTGS2, SLC22A1, SLC6A4, TERT, TOP2A, TYR, XDH 2.15701
[MF] GO:0030554 adenyl nucleotide binding ABCG2, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.13716
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.1183
[MF] GO:0004971 None GRIA2, GRIA4 2.1183
[MF] GO:0032795 None ADORA1, ADRA2A 2.1183
[MF] GO:0015318 inorganic molecular entity transmembrane transporter activity GRIA2, GRIA4, GRIK5, KCNH2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, TRPV1 2.06677
[MF] GO:0022857 None ABCG2, BCL2, GRIA2, GRIA4, GRIK5, KCNH2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4, TRPV1 2.03026
[MF] GO:0015291 None SLC1A1, SLC22A1, SLC22A2, SLC47A1, SLC47A2, SLC6A2, SLC6A4 2.01318


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.4934
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, PRKCG, GRIA2, GRM5, PRKCB, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 9.2412
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.2947
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PIK3CA, PRKCB, SRC, MMP2, KDR, PRKCA, PIK3CB, MMP9, MET, ESR1, IGF1R 8.008
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 7.7959
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, PRKCA, PIK3CB, TRPV1 7.5965
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB 7.5764
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, GRM1, ESR2 7.5965
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, TRPV1, F2, GRM1, ADRA2A, GRIA4 6.8713
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PIK3CA, PRKCB, PRKCE, BCL2, PIM1, CYP1B1, PRKCA, PTGS2, MMP9, MET, CDC25B 6.5756
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 6.9602
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, IGF1R, PIK3CA, BCL2, MET 6.2461
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB 6.4417
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, PTGS2, GRM1, GRIA4 6.4417
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 6.2785
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, PRKCB, ALOX5, PRKCA, PTGS2, CYP2C19, PTGS1, SLC6A4 6.1788
Hepatitis B_Homo sapiens_hsa05161 PRKCG, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 5.4067
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 5.5432
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.5709
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, MET, IGF1R 5.2929
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB, IGF1R 5.3266
Glioma_Homo sapiens_hsa05214 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, IGF1R 5.3115
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB 5.1949
Long-term depression_Homo sapiens_hsa04730 PRKCG, GRIA2, PRKCB, PRKCA, GRM1, IGF1R 5.4599
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, PRKCE, PRKCD, PIK3CB, PPARA 5.232
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.5267
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, GRM1 5.2929
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP2C19, CYP19A1, PTGS1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 4.6075
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 5.0614
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 5.0614
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB 4.6912
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, GRM8, PRKCA, PIK3CB, GRM1 4.5519
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2 4.3232
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.6278
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PIK3CA, PRKCB, KDR, PRKCA, PIK3CB, MET, IGF1R 4.2587
Gap junction_Homo sapiens_hsa04540 PRKCG, GRM5, PRKCB, SRC, PRKCA, GRM1 4.6761
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.4795
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.3428
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 5.1646
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.0087
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 4.1511
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA 3.5759
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PRKCE, ADORA1, PIK3CB, ADRA2A 3.3201
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.961
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 3.5046
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2, CYP2C19, PTGS1 4.2952
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.4492
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.416
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.0587
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 3.7744
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.0773
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 2.9763
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 2.9763
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.8996
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 2.5589
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.6476
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, GRM5, PRKCB, PRKCA, GRM1 2.4417
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 2.9767
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.0587
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.8077
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 2.9292
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.678
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2198
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.3798
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2286
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5571
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.2998
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2513
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 2.6478
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8557
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.6902
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.3996
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.7215
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.5358
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.017
Axon guidance_Homo sapiens_hsa04360 MET 0.3346
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3397
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.2777
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3397
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.5789
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.6245
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.299
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, GRM1, IGF1R 2.1371
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.5759
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.389
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3996
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6249
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.069
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4178
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, CSNK2A1, PRKCB, PRKCA 2.069
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6225
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4339
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PRKCE, PRKCD, PIK3CB 3.551
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4339
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7943
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 2.0234
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.6112
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4339
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4517
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4339
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB 1.7926
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.7865
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, F2 1.5364
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.767
Peroxisome_Homo sapiens_hsa04146 XDH 0.4517
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB 1.594
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.7972
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3191
Complement and coagulation cascades_Homo sapiens_hsa04610 F2 0.4639
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, PRKCB, PRKCA, CDC25B 1.333
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, TERT, PIK3CB 1.3206
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.4065
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.385
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.3894
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.4917
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.4277
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.505
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9427
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.3191
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 0.9535
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9535
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8199
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5297
Shigellosis_Homo sapiens_hsa05131 SRC 0.5296
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.7807
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5296
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.8289
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 1.8748
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.0991
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 2.045
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.584
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1539
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1309
Bile secretion_Homo sapiens_hsa04976 CA2, SLC22A1, ABCG2 2.069
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.2094
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.069
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6099
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.045
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1398
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP2C19 2.0861
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.2094
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.188
Malaria_Homo sapiens_hsa05144 MET 0.6225
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2245
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6249
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.2752
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.255
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.6529
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3469
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4277
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6874
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.4388
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.5461
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4675
DNA replication_Homo sapiens_hsa03030 POLA1 0.7261
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.5293
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.783
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.8077
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7978
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6148
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.8077
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8362
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7934
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8239
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8268
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7807
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6983
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.767
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.8471
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0314
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9987
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.077
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3925
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.155


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)