TCM Prescription: Gan Lu Ointment



Prescription Description
Prescription IDTCMF3502
Pinyin NameGan Lu Gao
Chinese Name甘露膏
English NameGan Lu Ointment
Function Description月经失调, 痛经, 带下病
IndicationsDysmenorrhea disorder, Leukorrhea disorder, Irregular menstruation
Disease ICD-11 Category SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ];
SC20 [Leukorrhea disorder (TM1), 带下病 (TM1) ];
GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2473 Leonurus japonicus 益母草 TCMH2473 ITSAN1807-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2578 Lycopi Herba 泽兰 TCMH2578
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH2295 fructus foeniculi 小茴香 TCMH2295
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH2216 Evodia rutaecarpa 吴茱萸 TCMH2216
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH12 Artemisia argyi 艾叶 TCMH12 ITSAE2504-14
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH907 Piper nigrum 胡椒 TCMH907 ITSAA3189-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT241 CHRNA7 Neuronal acetylcholine receptor protein alpha-7 subunit Ion channel P36544
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT552 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Ion channel P32297
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT629 ABCC1 Multidrug resistance-associated protein 1 Transporter P33527
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT642 ADRA1D Alpha-1d adrenergic receptor GPCR P25100
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT650 ADRA1B Alpha-1b adrenergic receptor GPCR P35368
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRNA3, CHRNA7, CNR2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR7, KCNH2, KDR, MET, MTNR1B, PPARA, PTGS1, PTGS2, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 17.3287
[BP] GO:0007187 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, CNR2, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B 16.4827
[BP] GO:0042221 response to chemical ABCB1, ADRA1A, ADRA2A, ADRB2, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CES1, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KCNH2, KDR, MMP2, MMP9, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 14.4013
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, ADRB2, APP, CA2, CA7, CHRNA3, CHRNA7, CNR2, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, PTGS2, SLC6A4 13.8928
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, ADRB2, APP, CA2, CA7, CHRNA3, CHRNA7, CNR2, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, PTGS2, SLC6A4 13.8928
[BP] GO:1901700 response to oxygen-containing compound ADRB2, AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD11B2, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, PPARA, PTGS2, RORC, SLC6A4, SRC, TYR 13.3249
[BP] GO:0007188 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 12.6067
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, AKR1B1, APP, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, GRM1, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 11.6318
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, AKR1B1, APP, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, GRM1, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 11.5923
[BP] GO:0010033 response to organic substance ADRA1A, ADRA2A, ADRB2, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, HTR5A, IGF1R, KDR, MMP2, PPARA, PTGS2, RORC, SLC6A4, SRC, TYR 11.2494
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, MTNR1B, PTGS2, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 11.2366
[BP] GO:0097756 None ADORA1, ADRA1A, ADRA1B, ADRA1D, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 11.2114
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, MTNR1B, PTGS2, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 11.0462
[BP] GO:0042493 response to drug ABCB1, ADRA1A, AKR1B1, AXL, BCL2, CA9, CDK6, CHRNA3, CHRNA7, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSD11B2, HTR2A, HTR2B, HTR2C, KCNH2, KDR, PTGS2, SLC6A2, SLC6A4, SRC 11.0462
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CHRNA3, CHRNA7, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F10, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TNKS2, TYR 10.8727
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.8555
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7182
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, ADRA1D, ADRA2A, AKR1B1, APP, BCL2, CDC25B, CDK6, CHRNA7, CSNK2A1, CXCL8, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SLC6A4, SRC, TERT, XDH 10.3653
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRNA3, CHRNA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 10.1844
[BP] GO:0003018 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4, SRC 10.1844
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PTGS1, PTGS2 10.172
[BP] GO:0097746 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 10.1609
[BP] GO:0035296 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 10.1609
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.1184
[BP] GO:0009719 response to endogenous stimulus ADRA1A, ADRA2A, ADRB2, AKR1B1, ALPL, APP, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CXCL8, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, HTR5A, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC 9.97938
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.93729
[BP] GO:0007193 None ADORA1, ADRA2A, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 9.85787
[BP] GO:0050880 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 9.85787
[BP] GO:0035150 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 9.82715
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KCNH2, MET, MTNR1B, SRC, TERT 9.68696
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRNA3, CHRNA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 9.56522
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, APP, CA2, CNR2, CXCL8, DRD1, DRD2, DRD3, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B, SIGMAR1, SRC 9.55643
[BP] GO:0007200 None ADRA1A, ADRA1B, ADRA1D, ADRA2A, DRD1, DRD2, ESR1, GRM5, HTR2A, HTR2B, HTR2C 9.27955
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SRC, TNKS, TNKS2 9.26
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, AKR1B1, APP, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, GRM1, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.24456
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, FUT7, GBA2, HTR2B, HTR2C, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 9.21163
[BP] GO:0007267 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRNA3, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, SLC1A1, SLC6A2 9.12376
[BP] GO:0042310 None ADRA1A, ADRA1B, ADRA1D, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 9.10347
[BP] GO:0023052 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRNA3, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, HTR7, KCNH2, MTNR1B, SLC1A1, SLC6A2 9.1029
[BP] GO:0048878 chemical homeostasis ADRA1A, ADRA1B, ADRA1D, ADRA2A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KCNH2, MET, MTNR1B 8.87902
[BP] GO:0007268 None CHRNA3, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, SLC1A1, SLC6A2 8.86633
[BP] GO:0098916 None CHRNA3, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, SLC1A1, SLC6A2 8.86633
[BP] GO:0007154 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, BCL2, CHRNA3, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, PTGS2, SLC1A1, SLC6A2 8.86633
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR5A, PTGS2, RORC, SLC6A4, SRC, TYR 8.85792
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 8.84362
[BP] GO:0003013 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4, SRC 8.78382
[BP] GO:0099536 None CHRNA3, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, SLC1A1, SLC6A2 8.74671
[BP] GO:0099537 None CHRNA3, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, SLC1A1, SLC6A2 8.74671
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, AKR1B1, APP, AXL, BCL2, CHRNA7, CYP1B1, DRD2, F10, F3, FLT3, GRM1, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, PTGS2, PTPN1, SRC, XDH 8.61943
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, DRD3, HCAR2, HTR2A, HTR2B, HTR2C, KDR, PTGS2, SRC, TNKS, TNKS2 8.61943
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 8.5701
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ADRB2, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CES1, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 8.53601
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 8.49442
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRB2, APP, AXL, BCL2, CA2, CA7, CDK6, CHRNA3, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, GRIK5, GRM5, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, MTNR1B, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 8.42852
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, ESRRB, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KDR, MMP9, MTNR1A, PTGS2, PTPN1, SRC, XDH 8.29242
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, ESRRB, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KDR, MMP9, MTNR1A, PTGS2, PTPN1, SRC, XDH 8.29242
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CHRNA3, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, MTNR1B 8.15726
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR2A, PTGS2 8.15726
[BP] GO:0006811 None ABCB1, ADRA1A, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, HTR2C, KCNH2, PPARA, SLC1A1, SLC6A2, SLC6A4 8.12747
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 8.07604
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 8.07604
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FLT3, HSD11B2, HTR5A, PTGS2, RORC, SLC6A4, SRC, TYR 8.06754
[BP] GO:0008284 positive regulation of cell proliferation ADRA1D, ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CHRNA7, CSNK2A1, DRD2, DRD3, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 8.02093
[BP] GO:0009725 response to hormone ADRA1A, ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, PPARA, PTGS2, SLC6A4, SRC 8.003
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, MTNR1A, PPARA, PTGS2, PTPN1, SRC, XDH 7.86314
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, AKR1B1, APP, AXL, BCL2, CHRNA7, CSNK2A1, CXCL8, CYP1B1, DRD2, DRD3, ESRRA, F10, F3, FABP4, FLT3, GRM1, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.83103
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, MTNR1A, PPARA, PTGS2, PTPN1, SRC, XDH 7.78473
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.73979
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DRD2, ESRRB, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 7.07902
[BP] GO:0050801 ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, BCL2, CA12, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, ESR1, FABP3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KCNH2 7.07345
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, CXCL8, DRD1, DRD2, DRD3, GRM5, HTR2B, HTR5A, KDR 7.05374
[BP] GO:0042391 None ADORA1, ADRA1A, ADRB2, APP, BCL2, CHRNA3, CHRNA7, CNR2, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC 7.05215
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADRA2A, ADRB2, APP, BCL2, CA2, CA7, CHRNA3, DRD1, DRD2, DRD3, GRM5, HTR1A, HTR2A, KCNH2, MMP9, PTGS2, SLC6A4 6.94075
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, PTGS1, RORC 6.94075
[BP] GO:0003008 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, APP, BCL2, CHRNA7, CNR2, CYP1B1, DRD1, DRD2, DRD3, GRM1, GRM5, GRM8, HSD11B2, HTR1A, HTR2A, HTR2B, HTR7, KCNH2, PTGS2, SLC6A4, SRC, TYR 6.8802
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 6.87357
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 6.84397
[BP] GO:0071880 None ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD2 6.82611
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 6.80647
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, AKR1B1, APP, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, F10, F3, FLT3, GRM1, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 6.77624
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 6.74916
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, ADRB2, APP, CA2, CA7, CHRNA7, DRD1, DRD2, PTGS2 6.72003
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.70454
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR2C, KDR, SRC 6.63276
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, BCL2, CA12, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KCNH2 6.6061
[BP] GO:0019933 None ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD1, DRD2, DRD3, HTR5A 6.58603
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, ADRB2, APP, AXL, BCL2, CA2, CA7, CHRNA3, CYP19A1, DRD1, DRD2, DRD3, GRIK5, GRM5, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, KCNH2, MMP12, MMP9, MTNR1B, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT 6.57939
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, MTNR1A, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 6.54076
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR2A, PTGS2, SLC6A4 6.49639
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, CHRNA7, DRD2, FLT3, GRM1, HTR2A, HTR2B, HTR2C, KDR, PTPN1, SRC, XDH 6.48587
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, BCL2, CHRNA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C 6.4808
[BP] GO:0006940 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, CHRNA3, PTGS2 6.45615
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, CHRNA3, DRD2, DRD3, GRM1, HCAR2, HTR2A, HTR2C, KCNH2, PTGS2, SLC1A1 6.40108
[BP] GO:0071875 None ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD2 6.37092
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB2, AKR1B1, APP, AURKB, BCL2, CA2, CHRNA7, CYP1A1, DRD1, DRD2, DRD3, GRM1, HSD11B2, HTR2A, HTR2B, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT, TYR 6.33338
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, APP, AXL, BCL2, CA2, CDK6, CHRNA3, CHRNA7, CXCL8, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F3, GRM1, HCAR2, HTR2A, HTR2B, HTR2C, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SLC1A1, SLC6A4, SRC, TERT, TNKS2, XDH 6.32497
[BP] GO:0055074 calcium ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, BCL2, CHRNA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C 6.32348
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, ADRB2, AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KCNH2, KDR, MMP2, MMP9, PTGS2, RORC, SLC6A4, SRC, TERT 6.31686
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 6.27807
[BP] GO:0019935 None ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD1, DRD2, DRD3, HTR5A 6.27807
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, ADRA1B, ADRA1D, APP, BCL2, CHRNA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C 6.26165
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, ESRRB, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 6.20906
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CES1, CHRNA7, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SLC6A4, SRC 6.20906
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, ESR1, HTR7, MTNR1A, MTNR1B, PPARA, RORC, SLC6A4, SRC 6.19703
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, MTNR1A, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.19276
[BP] GO:0007610 None APP, BCL2, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR2C, MTNR1A, PPARA, PTGS2, SLC6A4 6.18677
[BP] GO:0007189 None ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD1, DRD2, DRD3 6.15053
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, MTNR1A, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 6.13338
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, DRD2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 6.09602
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.07125
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, APP, AXL, BCL2, CA2, CHRNA7, CXCL8, CYP1B1, DRD2, DRD3, ESRRB, F3, HCAR2, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SLC1A1, SRC, TERT 6.0512
[BP] GO:0055080 cation homeostasis ADRA1A, ADRA1B, ADRA1D, APP, BCL2, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KCNH2 6.03664
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, ADRA1B, ADRA1D, APP, BCL2, CHRNA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C 6.01582
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, FABP3, FABP4, FUT7, GBA2, MET, PPARA, PTGS1, PTGS2 5.98517
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CES1, CHRNA3, CHRNA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SIGMAR1, SLC6A4, SRC, TERT, TNKS2, TYR 5.90354
[BP] GO:0030003 cellular cation homeostasis ADRA1A, ADRA1B, ADRA1D, APP, BCL2, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C 5.90354
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, RORC, SRC 5.89959
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GRM1, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.88539
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, BCL2, CDK6, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 5.881
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, ADRA1B, ADRA1D, APP, BCL2, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, ESR1, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C 5.79948
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CHRNA3, CYP1B1, DRD1, DRD2, DRD3, GRIK5, HTR1A, PTGS2, SLC1A1, SLC6A2, SLC6A4 5.77345
[BP] GO:0006873 cellular ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, BCL2, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C 5.7695
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 5.7695
[BP] GO:1901698 response to nitrogen compound ADRB2, AKR1B1, APP, CHRNA3, CHRNA7, CNR2, DRD1, DRD2, DRD3, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC, TYR 5.76006
[BP] GO:0045744 None ADRA2A, ADRB2, CXCL8, DRD2, DRD3, MET 5.74759
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, BCL2, CDK6, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 5.74759
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CHRNA7, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 5.71375
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, CNR2, DRD2 5.66682
[BP] GO:0032225 None DRD1, DRD2, DRD3, PTGS2, SLC6A4 5.66682
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 5.57474
[BP] GO:0010243 response to organonitrogen compound ADRB2, AKR1B1, APP, CHRNA7, CNR2, DRD1, DRD2, DRD3, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC, TYR 5.56918
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 5.55757
[BP] GO:0071310 cellular response to organic substance ADRA2A, ADRB2, AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CXCL8, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, PTGS2, RORC, SLC6A4, SRC 5.55283
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PTGS2, SRC, TERT 5.49957
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.4818
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.4818
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 5.47821
[BP] GO:0051588 None CHRNA3, DRD1, DRD2, DRD3, GRIK5, HTR1A, HTR2C, SLC6A4 5.46306
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 5.38811
[BP] GO:0055065 metal ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, BCL2, CHRNA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KCNH2 5.38811
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, ADRB2, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, HCAR2, HTR2B, KCNH2, MMP12, PTGS2, SLC6A4, SRC, TERT 5.35446
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, PPARA, PTGS1, PTGS2 5.31199
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, GBA2, HTR1A, TYR 5.26147
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, ADRB2, APP, AURKB, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 5.26027
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, BCL2, CHRNA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C 5.2526
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, CHRNA7, DRD2, FLT3, GRM1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, PTPN1, SRC, XDH 5.2451
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, BCL2, CDK6, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 5.21274
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 5.21274
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS1, PTGS2, TYR, XDH 5.20075
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.17559
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, ADRB2, BCL2, CNR2, CXCL8, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 5.16577
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, ADRB2, BCL2, CNR2, CXCL8, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 5.14262
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, DRD2, DRD3, HTR2A, KCNH2, MMP9, PTGS2 5.12902
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRA2A, ADRB2, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CNR2, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, HTR2B, IGF1R, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 5.12902
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ADRB2, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HTR2A, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 5.09154
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 5.01473
[BP] GO:0090066 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 5.00836
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.99157
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 4.99157
[BP] GO:1901701 cellular response to oxygen-containing compound ADRB2, AKR1B1, APP, AXL, CDK6, CXCL8, CYP1B1, DRD1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PTGS2, RORC, SLC6A4, SRC 4.96321
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, BCL2, CXCL8, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.95654
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.95003
[BP] GO:0008217 None ADORA1, ADRA1A, ADRB2, DRD2, DRD3, HSD11B2, PPARA, PTGS1, PTGS2 4.9421
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CHRNA3, CYP19A1, DRD2, DRD3, GRIK5, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, SLC6A4, SRC 4.86245
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA1A, ADRA2A, ADRB2, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, HTR2B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 4.85177
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.78983
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.78983
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, BCL2, CXCL8, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.78396
[BP] GO:0051952 None ADORA1, ADRA2A, CHRNA3, DRD1, DRD2, DRD3, HTR2A 4.76797
[BP] GO:0060078 None ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM5 4.73241
[BP] GO:0019725 cellular homeostasis ADRA1A, ADRA1B, ADRA1D, APP, BCL2, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, ESR1, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C 4.71535
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR 4.69932
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 4.68343
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, BCL2, CXCL8, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.65186
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, AKR1B1, APP, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CXCL8, CYP1B1, DRD2, DRD3, ESR1, ESR2, F10, F3, FLT3, GRM1, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.56322
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 4.52417
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 4.50798
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, BCL2, CXCL8, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.47908
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA1A, ADRA2A, ADRB2, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, DRD2, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, MET, MMP9, PTPN1, SRC, TERT, TNKS, XDH 4.46746
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CHRNA3, CYP19A1, DRD2, DRD3, GRIK5, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, SLC6A4, SRC 4.45745
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, ADRA1B, ADRA1D, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C 4.4469
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, DRD2, HTR2A, KCNH2, PTGS2, SLC1A1 4.4469
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, HCAR2, PTGS2, TNKS, TNKS2 4.4469
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SIGMAR1, SRC, TERT, XDH 4.43791
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 4.42553
[BP] GO:1904645 response to amyloid-beta ADRB2, APP, CHRNA7, GRM5, IGF1R 4.33038
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 4.32597
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, GRM3, GRM8, HTR2A, MTNR1A, PPARA 4.32071
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.2823
[BP] GO:0001994 None ADRA1A, ADRA1B, ADRA1D 4.2823
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.2823
[BP] GO:0001659 None ADORA1, ADRB2, DRD1, DRD2, HTR2A 4.2698
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, ADRB2, CDC25B, CHRNA3, CHRNA7, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, PTPN1, SRC 4.24479
[BP] GO:0006140 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, GRM3, GRM8, HTR2A, MTNR1A, PPARA 4.21755
[BP] GO:0007623 circadian rhythm DRD2, DRD3, HTR7, MTNR1A, MTNR1B, PPARA, RORC, SLC6A4 4.21663
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.19367
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, ADRB2, AURKB, CDC25B, CHRNA3, CHRNA7, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, PTPN1, SRC, TNKS 4.18544
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ADRA1A, ADRA2A, ADRB2, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRNA3, CHRNA7, CXCL8, DRD1, DRD2, DRD3, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, HTR2C, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.1811
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ADRB2, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HCAR2, HTR2A, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.17066
[BP] GO:0019229 None ADRA1A, ADRA1B, ADRA1D, ADRA2A, HTR2A, PTGS2 4.16132
[BP] GO:0045907 None ADRA1A, ADRA1B, ADRA1D, HTR2A, PTGS2 4.14686
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.1249
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, ADRB2, BCL2, CDK6, CNR2, CXCL8, CYP19A1, DRD1, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 4.1249
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, ADRA1B, ADRA1D, DRD1, DRD2, ESR1, GRM1, HTR2A, HTR2B, HTR2C 4.1249
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRNA3, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HTR5A, KDR, MMP9, PIM1, PPARA, PTGS2, RORC, SIGMAR1, SRC, TYR 4.1249
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ADRA1A, ADRA2A, ADRB2, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRNA3, CHRNA7, CXCL8, DRD1, DRD2, DRD3, F10, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, HTR2C, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, XDH 4.1249
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ADRB2, APP, CDC25B, CHRNA3, CHRNA7, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, PTPN1, SRC 4.07416
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, APP, CHRNA7, DRD2, HTR2A, HTR2B, HTR2C, KDR, SRC 4.02282
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.0097
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, ADRA1A, ADRA2A, ADRB2, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRNA3, CHRNA7, CXCL8, DRD1, DRD2, DRD3, F10, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, HTR2C, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TNKS, XDH 3.97378
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 3.96931
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SIGMAR1, SRC, TERT, XDH 3.96931
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, ADRB2, CDC25B, CHRNA3, CHRNA7, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, PTPN1, SRC 3.95808
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.93337
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, CHRNA3, CYP19A1, DRD2, HCAR2, HTR1A, HTR2A, HTR2C, MTNR1B 3.91737
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, ADRA2A, ADRB2, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, PTPN1, SRC, TERT, TNKS, XDH 3.9153
[BP] GO:0040014 regulation of multicellular organism growth ADRB2, APP, BCL2, DRD2, DRD3, TNKS2 3.90832
[BP] GO:0043393 regulation of protein binding ADRB2, APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.89974
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 3.87997
[BP] GO:0051716 cellular response to stimulus ADRA2A, ADRB2, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KCNH2, KDR, MMP2, MMP9, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT 3.85351
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRB2, APP, AURKB, CDC25B, CHRNA3, CHRNA7, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, PTPN1, SRC, TNKS 3.85351
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.84487
[BP] GO:0060079 None ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.84453
[BP] GO:1903524 None ADRA1A, ADRA1B, ADRA1D, HTR2A, PTGS2, SLC1A1 3.80898
[BP] GO:0050890 None ADORA1, APP, CHRNA7, DRD1, DRD2, DRD3, GRM5, HTR2A, PTGS2, SLC6A4 3.80419
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, APP, CHRNA7, DRD2, HTR2A, HTR2B, HTR2C, KDR, PTPN1, SRC 3.77717
[BP] GO:1900543 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PPARA 3.77695
[BP] GO:0051098 regulation of binding ADRB2, APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC, TERT, TNKS 3.75201
[BP] GO:0044237 cellular metabolic process ACHE, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 3.74688
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 3.74688
[BP] GO:0045980 None ADRA2A, DRD2, DRD3, GRM3, GRM8, PPARA 3.74688
[BP] GO:0006937 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, CHRNA3, PTGS2 3.7326
[BP] GO:0009891 positive regulation of biosynthetic process ADRB2, APP, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MTNR1A, PPARA, PTGS2, RORC, SRC, TERT, TNKS, TNKS2 3.73067
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRB2, APP, CDC25B, CHRNA3, CHRNA7, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, PTPN1, SRC 3.69166
[BP] GO:1901652 response to peptide ADRB2, AKR1B1, APP, CHRNA7, FABP3, GRM5, HSD11B2, IGF1R, PPARA, PTGS2, SRC 3.68965
[BP] GO:0045776 None ADORA1, ADRB2, DRD2, DRD3, PPARA 3.67185
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.67107
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC 3.67007
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 3.63215
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 3.63005
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB2, AKR1B1, DRD1, DRD2, HTR2A, MET 3.61755
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.60185
[BP] GO:0030802 None ADRA2A, DRD1, DRD2, DRD3, GRM3, GRM8, MTNR1A 3.5959
[BP] GO:0030818 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.58349
[BP] GO:0022898 None ABCB1, ADRA2A, ADRB2, APP, BCL2, DRD2, DRD3, GRM5, MMP9 3.56536
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HTR2B, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SIGMAR1, SRC, TERT, XDH 3.54422
[BP] GO:0034762 None ABCB1, ADRA2A, ADRB2, APP, BCL2, CA2, DRD1, DRD2, DRD3, GRM5, KCNH2, MMP9 3.53355
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, BCL2, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 3.49562
[BP] GO:0030803 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.49562
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.49418
[BP] GO:0007611 None APP, CHRNA7, DRD1, DRD2, DRD3, GRM5, HTR2A, PTGS2, SLC6A4 3.46942
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3 3.4591
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.45723
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, AXL, BCL2, CXCL8, CYP1B1, DRD1, DRD2, DRD3, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MET, PTPN1, SRC 3.45304
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.45002
[BP] GO:0007626 None APP, CHRNA3, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2C 3.42974
[BP] GO:0030815 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.41468
[BP] GO:1900371 None ADRA2A, DRD1, DRD2, DRD3, GRM3, GRM8, MTNR1A 3.38773
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 3.38184
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB2, APP, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, MET, MMP12, MTNR1A, PPARA, PTGS2, RORC, SRC, TERT, TNKS, TNKS2 3.38164
[BP] GO:0032409 None ABCB1, ADRA2A, ADRB2, APP, BCL2, DRD2, DRD3, GRM5, MMP9 3.3807
[BP] GO:1900372 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.37759
[BP] GO:0030809 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.37759
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.37593
[BP] GO:0030808 None ADRA2A, DRD1, DRD2, DRD3, GRM3, GRM8, MTNR1A 3.37593
[BP] GO:0030800 None ADRA2A, DRD2, DRD3, GRM3, GRM8 3.34135
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.30898
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.28067
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.28067
[BP] GO:2001023 None CHRNA3, DRD1, DRD2, DRD3, HTR2A, MET 3.27169
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGS2, TERT 3.26509
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TNKS 3.18774
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, HTR2C, SLC6A2 3.18358
[BP] GO:0030534 None APP, CHRNA3, DRD1, DRD2, DRD3, HTR2A, PPARA 3.17835
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.17552
[BP] GO:0001975 None CNR2, DRD1, DRD2, DRD3 3.17552
[BP] GO:0008283 cell proliferation ABCB1, ACHE, ADRA1B, ADRA1D, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIM1, SRC, TYR 3.16921
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, ADRB2, APP, AXL, BCL2, CA1, CSNK2A1, CXCL8, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 3.15811
[BP] GO:0031623 None ACHE, CXCL8, DRD2, DRD3, HTR2B 3.15264
[BP] GO:0030799 None ADRA2A, DRD1, DRD2, DRD3, GRM3, GRM8, MTNR1A 3.14667
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 3.12837
[BP] GO:1904646 cellular response to amyloid-beta ADRB2, APP, GRM5, IGF1R 3.11742
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 3.11426
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, CHRNA7, FLT3, GRM1, HTR2A, HTR2B, PTPN1, SRC 3.11234
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2 3.10281
[BP] GO:0030817 None ADRA2A, DRD1, DRD2, DRD3, GRM3, GRM8 3.05498
[BP] GO:0043266 None ADORA1, ADRA2A, DRD1, DRD2, HTR2A, KCNH2 3.05498
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, CHRNA7, FLT3, GRM1, HTR2A, HTR2B, IGF1R, PTPN1, SRC 3.04914
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 3.04086
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.01806
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT 3.01806
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, MTNR1A, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 2.9843
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, ADRB2, AKR1B1, APP, CXCL8, DRD1, ESR1, FLT3, GRM5, IGF1R, MMP2, PTGS2, SLC6A4, SRC 2.9829
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F10, F3, MET, SRC, XDH 2.96711
[BP] GO:0035265 organ growth ADRA1A, BCL2, CYP19A1, ESR1 2.95039
[BP] GO:0002209 None BCL2, DRD1, HTR1A, HTR2C 2.95039
[BP] GO:0001662 None BCL2, DRD1, HTR1A, HTR2C 2.95039
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR2, CXCL8, CYP19A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, PTGS2 2.95012
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, ADRB2, CHRNA7, FLT3, GRM1, HTR2A, HTR2B, PTPN1, SRC 2.94707
[BP] GO:0045766 positive regulation of angiogenesis CHRNA7, CXCL8, CYP1B1, F3, KDR, PTGS2, TERT 2.94707
[BP] GO:0048167 None ADORA1, APP, CHRNA7, DRD1, DRD2, GRM5, PTGS2 2.94707
[BP] GO:0098657 import into cell ACHE, ADORA1, ADRB2, APP, AXL, CXCL8, DRD2, DRD3, HTR2B, SLC1A1, SLC6A2, SLC6A4 2.91532
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, KCNH2, KDR, PTGS2, SRC 2.91426
[BP] GO:0010959 None ADORA1, ADRA2A, ADRB2, BCL2, DRD1, DRD2, DRD3, HTR2A, KCNH2, PTGS2 2.91223
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.9113
[BP] GO:0007613 None CHRNA7, DRD1, DRD2, HTR2A, PTGS2, SLC6A4 2.9113
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AURKB, BCL2, CHRNA7, CNR2, CSNK2A1, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.89057
[BP] GO:0002031 None DRD2, DRD3, HTR2B 2.87354
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.87354
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B, HTR2C 2.87354
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 2.87154
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, BCL2, CDK6, CXCL8, CYP1B1, DRD2, FABP3, PTGS2, SLC6A4, TERT, XDH 2.87154
[BP] GO:0007194 None ADRA2A, DRD2, DRD3, GRM3 2.85941
[BP] GO:0042596 None BCL2, DRD1, HTR1A, HTR2C 2.85941
[BP] GO:0032412 None ABCB1, ADRA2A, ADRB2, APP, DRD2, DRD3, GRM5, MMP9 2.83668
[BP] GO:0007208 None HTR2A, HTR2C 2.81476
[BP] GO:0009115 None AOX1, XDH 2.81476
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.81476
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, DRD2, DRD3, HCAR2, HTR2B, HTR2C, MMP12, MTNR1B, PTGS2, PTPN1, SRC 2.80045
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADRA2A, APP, CDK6, CNR2, CYP19A1, DRD2, ESR1, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.79807
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, DRD2, DRD3, HCAR2, HTR2B, HTR2C, MMP12, MTNR1B, SRC 2.77223
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.77223
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A4 2.77223
[BP] GO:0090257 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, CHRNA3, PTGS2 2.77165
[BP] GO:0045987 None ADRA1A, ADRA1B, ADRA1D, PTGS2 2.77165
[BP] GO:0031280 None ADRA2A, DRD2, DRD3, GRM3 2.77165
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, SRC, XDH 2.76671
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.76077
[BP] GO:0050730 None ADORA1, ADRA2A, APP, FLT3, GRM5, HTR2A, PTPN1, SRC 2.73482
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 2.72487
[BP] GO:0030814 None ADRA2A, DRD1, DRD2, DRD3, GRM3, GRM8 2.70048
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.68479
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HCAR2, HTR2B, MMP12, SLC6A4, SRC 2.68165
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.68165
[BP] GO:0051350 None ADRA2A, DRD2, DRD3, GRM3 2.68165
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.67742
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.67742
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.67742
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, GRM5, HTR2A, PTPN1, SRC 2.67618
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS1, PTGS2 2.67288
[BP] GO:0043270 None ABCB1, ADORA1, ADRA2A, ADRB2, DRD1, DRD2, KCNH2, SLC6A4 2.65914
[BP] GO:1904018 positive regulation of vasculature development CHRNA7, CXCL8, CYP1B1, F3, KDR, PTGS2, TERT 2.65041
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.64576
[BP] GO:0061097 None ADORA1, ADRA2A, APP, GRM5, PTPN1 2.61589
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, ADRB2, CHRNA3, CHRNA7, DRD2, GRM1, PTPN1, SRC 2.60854
[BP] GO:0014075 None CNR2, DRD1, DRD2, DRD3 2.60416
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.59115
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.59115
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.59115
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT 2.58541
[BP] GO:0071417 cellular response to organonitrogen compound ADRB2, AKR1B1, APP, DRD1, GRM5, IGF1R, MMP2, PTGS2, SLC6A4, SRC 2.58429
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.56977
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B, HTR2C 2.56977
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, PTGS2, SLC6A4 2.56874
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 2.55021
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, ADRA2A, ADRB2, BCL2, CXCL8, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.54602
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 2.51832
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.50646
[BP] GO:0051937 None DRD1, SLC6A2, SLC6A4 2.50646
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.50646
[BP] GO:0008277 regulation of G-protein coupled receptor protein signaling pathway ADRA2A, ADRB2, CXCL8, DRD2, DRD3, MET 2.49849
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.44869
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC1A1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 2.43183
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5 2.4264
[BP] GO:1900273 None APP, CHRNA7, DRD2 2.4264
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.4264
[BP] GO:0045986 None ADORA1, ADRB2, PTGS2 2.4264
[BP] GO:0050793 regulation of developmental process ADRB2, APP, AXL, BCL2, CA2, CDK6, CHRNA3, CHRNA7, CXCL8, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F3, HTR2A, HTR2C, KDR, PIM1, PPARA, PTGS2, RORC, SLC6A4, SRC, TERT, TNKS2, XDH 2.42539
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.41643
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.41643
[BP] GO:0061098 None ADORA1, ADRA2A, GRM5, PTPN1 2.41643
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, ADRB2, CHRNA7, FLT3, GRM1, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.41414
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.41414
[BP] GO:0099566 None GRM1, GRM5 2.41414
[BP] GO:0046110 None AOX1, XDH 2.41414
[BP] GO:0060160 None DRD2, DRD3 2.41414
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41414
[BP] GO:1905144 None CHRNA3, CHRNA7 2.41414
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.41414
[BP] GO:0050877 None ADORA1, APP, CHRNA7, CNR2, CYP1B1, DRD1, DRD2, DRD3, GRM1, GRM5, GRM8, HTR2A, PTGS2, SLC6A4, TYR 2.40708
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.393
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 2.39166
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.38874
[BP] GO:0007612 None APP, DRD1, DRD2, DRD3, GRM5, PTGS2 2.38075
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.36896
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A4 2.36896
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.36464
[BP] GO:0045761 None ADRA2A, DRD2, DRD3, GRM3 2.36403
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C 2.36403
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C 2.36403
[BP] GO:0097366 None CNR2, DRD1, DRD2, DRD3 2.36403
[BP] GO:0034765 None ABCB1, ADRA2A, ADRB2, APP, DRD1, DRD2, DRD3, GRM5, KCNH2, MMP9 2.35971
[BP] GO:1901699 cellular response to nitrogen compound ADRB2, AKR1B1, APP, DRD1, GRM5, IGF1R, MMP2, PTGS2, SLC6A4, SRC 2.34388
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.34052
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, MTNR1A, PTGS2, SLC6A4, SRC 2.33933
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 2.3291
[BP] GO:0060359 None CHRNA3, CHRNA7, DRD1, DRD2, DRD3 2.31697
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.3044
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.3044
[BP] GO:0050433 None ADRA2A, DRD2, DRD3, HTR2A 2.2989
[BP] GO:0050808 None ACHE, APP, CHRNA7, DRD1, DRD2, GRM5 2.28056
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.28056
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR2, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.27232
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.26711
[BP] GO:0051094 positive regulation of developmental process ADRB2, APP, AXL, BCL2, CA2, CHRNA7, CXCL8, CYP1B1, DRD2, ESRRB, F3, HTR2A, HTR2C, KDR, PIM1, PTGS2, SRC, TERT 2.25086
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.24153
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.24153
[BP] GO:0007617 None APP, DRD1, MTNR1A 2.24153
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.23775
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TNKS 2.23449
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APP, AURKB, BCL2, CHRNA7, CSNK2A1, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HTR2B, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.21928
[BP] GO:0015893 None ABCB1, CA2, DRD1, SLC1A1, SLC6A2, SLC6A4 2.21047
[BP] GO:0045933 None ADRA1A, ADRA1B, ADRA1D, PTGS2 2.20745
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.19989
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, DRD3, PTGS2, TYR 2.19989
[BP] GO:0016477 cell migration AXL, CNR2, CXCL8, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.19371
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 2.18832
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.18475
[BP] GO:1904062 None ADRA2A, ADRB2, APP, DRD1, DRD2, DRD3, KCNH2, MMP9 2.18475
[BP] GO:0043112 None ACHE, CXCL8, DRD2, DRD3, HTR2B 2.18475
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.18475
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB2, APP, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, HTR2A, IGF1R, MET, MMP12, MTNR1A, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2 2.17624
[BP] GO:0070213 None TNKS, TNKS2 2.16699
[BP] GO:0006145 None AOX1, XDH 2.16699
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.16699
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.16699
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB2, AKR1B1, APP, AXL, BCL2, CA2, CA9, CHRNA7, CNR2, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HSD11B2, HTR1A, HTR2C, MMP2, MMP9, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT 2.16558
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.15688
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, SLC6A4, SRC, TERT 2.15222
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, PTGS2, SRC 2.14102
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 2.13314
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.13314
[BP] GO:0015844 None DRD1, SLC6A2, SLC6A4 2.13314
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.13314
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.13086
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.13086
[BP] GO:0051100 negative regulation of binding ADRB2, AURKB, CYP2D6, MET, PPARA, TNKS 2.12635
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, PTGS2, SRC 2.12635
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, MTNR1A, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.12635
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR2, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.11158
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.09835
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.07891
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.07891
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.07891
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRB2, APP, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, MTNR1A, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.07779
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.07594
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.05814
[BP] GO:0051953 None ADORA1, ADRA2A, DRD2 2.0245
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.0245
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.0245
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, HTR2C 2.01955
[BP] GO:0007568 aging ADRA1A, AURKB, BCL2, CYP1A1, HTR2A, PTGS2, TERT 2.01716
[BP] GO:0006351 None CSNK2A1, ESR1 2.01909
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, APP, AXL, CA4, CNR2, DRD1, DRD2, DRD3, F10, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, SLC1A1, SLC6A2, SLC6A4 13.1778
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, APP, AXL, CA2, CA4, CA9, CHRNA3, CHRNA7, CNR2, DRD1, DRD2, DRD3, F10, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MTNR1A, MTNR1B, PTGS2, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC 11.7582
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, APP, AXL, CNR2, DRD1, DRD2, DRD3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, SLC1A1, SLC6A2, SLC6A4 11.3758
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRNA3, CHRNA7, CNR2, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT 9.8139
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR 9.37119
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRNA3, CHRNA7, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MTNR1A, MTNR1B, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TYR 9.04843
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, CA2, CA4, CA9, CHRNA3, CHRNA7, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, MET, PTGS2, SIGMAR1, SLC1A1, SRC 8.61943
[CC] GO:0043005 None ADORA1, APP, CA2, CHRNA3, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, PTGS2, SLC6A2, SLC6A4, SRC 5.30817
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, F10, FLT3, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1, SIGMAR1 5.12902
[CC] GO:0031224 None ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CHRNA3, CHRNA7, CNR2, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, TYR 4.73997
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CDK6, CHRNA3, CNR2, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PTGS2, SLC6A2, SLC6A4, SRC 4.61717
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CDK6, CHRNA3, CNR2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PTGS2, SLC6A2, SLC6A4, SRC 4.45921
[CC] GO:0045121 membrane raft ADRA1A, ADRA1B, APP, CHRNA3, CHRNA7, HTR2A, KDR, PTGS2, SLC6A2, SLC6A4, SRC 4.335
[CC] GO:0098857 membrane microdomain ADRA1A, ADRA1B, APP, CHRNA3, CHRNA7, HTR2A, KDR, PTGS2, SLC6A2, SLC6A4, SRC 4.31286
[CC] GO:0044853 plasma membrane raft ADRA1A, ADRA1B, CHRNA3, CHRNA7, HTR2A, PTGS2, SRC 4.2823
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRNA3, CHRNA7, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1, SLC6A4, SRC 4.11923
[CC] GO:0014069 None ADORA1, CHRNA3, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 4.00931
[CC] GO:0099572 None ADORA1, CHRNA3, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 4.00931
[CC] GO:0043235 receptor complex ADRA2A, ADRB2, APP, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, MTNR1A 3.9861
[CC] GO:0016021 None ABCB1, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, ALPL, APP, AXL, CA12, CA14, CA9, CHRNA3, CHRNA7, CNR2, DRD1, DRD2, DRD3, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, TYR 3.89302
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, SIGMAR1 3.84759
[CC] GO:0098589 membrane region ADRA1A, ADRA1B, APP, CHRNA3, CHRNA7, HTR2A, KDR, PTGS2, SLC6A2, SLC6A4, SRC 3.63603
[CC] GO:0097060 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1 3.62058
[CC] GO:0097458 None ADORA1, APP, CA2, CHRNA3, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, PTGS1, PTGS2, SIGMAR1, SLC6A2, SLC6A4, SRC 3.51721
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GBA2, GRIK5, HTR5A, KDR, PTGS2, PTPN1, SIGMAR1, XDH 3.16515
[CC] GO:0098794 None ADORA1, APP, CHRNA7, DRD2, GRIA2, GRIA4, GRM3 2.97464
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 2.92997
[CC] GO:0005901 caveola ADRA1A, ADRA1B, HTR2A, PTGS2, SRC 2.68479
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.67187
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CDC25B, CDK6, CES1, CES2, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.63723
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.63682
[CC] GO:0045211 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM3, SIGMAR1 2.22043
[CC] GO:0031233 None CA4, F10, F3 2.18475
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AXL, CHRNA3, CHRNA7, CNR2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, SIGMAR1 18.567
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AXL, CDK6, CHRNA3, CHRNA7, CNR2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, SIGMAR1 17.3287
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AXL, CHRNA3, CHRNA7, CNR2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, SIGMAR1 17.0645
[MF] GO:0030594 None CHRNA3, CHRNA7, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 16.2658
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.921
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AXL, CHRNA3, CHRNA7, CNR2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, SIGMAR1 15.6987
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 14.6541
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AXL, CHRNA3, CHRNA7, CNR2, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, SIGMAR1 14.4013
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AXL, CHRNA3, CHRNA7, CNR2, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, SIGMAR1 14.4013
[MF] GO:0008227 None ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 14.3044
[MF] GO:0070405 ammonium ion binding ACHE, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, SLC6A4 12.9292
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 10.7182
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TYR, XDH 10.5233
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.82715
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, CNR2, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B, SIGMAR1 9.58508
[MF] GO:0042165 neurotransmitter binding ACHE, CHRNA3, CHRNA7, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 8.61943
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.61943
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 8.5701
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 8.5701
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 8.07604
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 8.07604
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.82931
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.71439
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 7.69085
[MF] GO:0004935 None ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, DRD2 7.45419
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 7.34515
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TYR 6.84397
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, XDH 6.71976
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 6.6671
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS1, PTGS2, TYR, XDH 6.51341
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 6.49639
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.4808
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, TYR 6.4521
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6 6.20751
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, PPARA, SIGMAR1, SLC6A4, SRC 6.1634
[MF] GO:0004936 None ADRA1A, ADRA1B, ADRA1D, ADRA2A 5.79981
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 5.78595
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 5.51349
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B2, HSD17B1, PTGS1, PTGS2, SRC, XDH 5.26926
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.1934
[MF] GO:1901338 None ADRA2A, ADRB2, DRD1, DRD2, DRD3 5.18271
[MF] GO:0004937 None ADRA1A, ADRA1B, ADRA1D 4.81571
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TYR, XDH 4.73062
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.63432
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.63432
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.43791
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.21663
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.19686
[MF] GO:0098960 None CHRNA3, CHRNA7, GRM1, GRM5 3.52013
[MF] GO:0005231 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.41468
[MF] GO:0042562 hormone binding ACHE, CHRNA3, CHRNA7, HSD17B1, IGF1R, MTNR1A 3.37616
[MF] GO:0022824 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.34135
[MF] GO:0022835 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.34135
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.11742
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRB2, AOX1, APP, BCL2, CHRNA7, CSNK2A1, DRD2, ESR1, ESR2, FLT3, GRIK5, IGF1R, KCNH2, KDR, MET, MMP9, PTGS2, SLC6A4, TERT, TYR, XDH 3.05527
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.00264
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, ADRB2, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 2.93292
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 2.92997
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ADRB2, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 2.89964
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.81476
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.81476
[MF] GO:0003845 None HSD11B1, HSD11B2 2.81476
[MF] GO:0008389 None CYP2A13, CYP2A6 2.81476
[MF] GO:0071886 None HTR2A, HTR2C 2.81476
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.77223
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.67742
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CHRNA3, CHRNA7, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.67595
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.65327
[MF] GO:0005230 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 2.59115
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.49753
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 2.48248
[MF] GO:0008502 None MTNR1A, MTNR1B 2.41414
[MF] GO:0005330 None SLC6A2, SLC6A4 2.41414
[MF] GO:0099583 None GRM1, GRM5 2.41414
[MF] GO:0047374 None CES1, CES2 2.41414
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.39166
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, ADRB2, AOX1, BCL2, CHRNA7, DRD2, FLT3, KCNH2, PTGS2, SLC6A4, TERT, TYR, XDH 2.39166
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.36896
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.36896
[MF] GO:0042166 None ACHE, CHRNA3, CHRNA7 2.36896
[MF] GO:0015276 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, KCNH2 2.34065
[MF] GO:0022834 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, KCNH2 2.34065
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA1A, ADRA1B, ADRA2A, ADRB2, AOX1, AXL, BCL2, CHRNA7, DRD2, FLT3, KCNH2, PTGS2, SLC6A4, TERT, TYR, XDH 2.27425
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.24153
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.24153
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.18475
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.16699
[MF] GO:0004971 None GRIA2, GRIA4 2.16699
[MF] GO:0032795 None ADORA1, ADRA2A 2.16699


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, CHRNA3, CHRNA7, GRIK5, HTR2B, HTR2C, ADRA1D, HTR2A, ADRB2, ADRA1B, ADRA1A, GRM1, GRM3, HTR6, GRM5, HTR7, CNR2, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, GRIA4, HTR1A, HTR5A, ADRA2A, MTNR1A, MTNR1B 27.0641
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR2B, HTR1A, HTR2C, HTR2A, PTGS2, HTR5A, CYP2C19, PTGS1, SLC6A4, HTR6, HTR7, CYP2D6, ALOX5 13.4407
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.8514
Calcium signaling pathway_Homo sapiens_hsa04020 CHRNA7, HTR2B, HTR2C, ADRA1D, HTR2A, ADRB2, HTR5A, ADRA1B, ADRA1A, GRM1, HTR6, GRM5, HTR7, DRD1 10.6629
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.2315
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CHRNA7, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 7.95
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.8398
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2B, HTR2C, HTR2A, DRD1, DRD2, GRM1 6.4279
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, HTR6, ADORA1, HTR1A, ADRB2, DRD1, DRD2, PPARA, GRIA4 5.8033
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 5.6819
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 5.7802
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP2C19, GBA2, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 4.228
Bladder cancer_Homo sapiens_hsa05219 CXCL8, SRC, MMP1, MMP2, MMP9 4.5591
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 3.8851
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.6275
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB2, PTGS2, PTGS1 3.9408
Pathways in cancer_Homo sapiens_hsa05200 CDK6, CXCL8, FLT3, MMP1, MMP2, BCL2, PTGS2, MMP9, MET, IGF1R 3.4907
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1D, ADRB2, ADRA1B, ADRA1A, ADRA2A 3.6192
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.1948
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP2C19 3.5979
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.4907
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 CXCL8, MMP2, BCL2, PIM1, F3 2.9598
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 2.9598
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, DRD2, DRD3, GRIA4 2.5286
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.3985
Hepatitis B_Homo sapiens_hsa05161 CDK6, CXCL8, SRC, BCL2, MMP9 2.313
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, CXCL8, GRM8, GRM1 2.3265
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRA1D, ADRB2, ADRA1B, ADRA1A 2.2996
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, CYP2C19, PTGS1 2.7557
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.1044
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.1948
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.6919
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2C, HTR2A 2.1503
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.6075
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, MTNR1A, MTNR1B, GRIA4 2.1888
Salivary secretion_Homo sapiens_hsa04970 ADRA1D, ADRB2, ADRA1B, ADRA1A 2.2702
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CHRNA3, CHRNA7, BCL2 1.9747
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 CXCL8, FLT3, MMP9, MET, IGF1R 1.9965
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CXCL8, CSNK2A1, BCL2, PTGS2 2.2113
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 1.8236
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 1.7632
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB2, MET, IGF1R 1.4764
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 1.83
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 1.8401
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 1.7542
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.702
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.7007
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.7632
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 1.0907
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.1104
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 1.5075
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 CXCL8, SRC, MET 1.7455
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.1778
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1D, ADRA1B, ADRA1A 1.1778
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 CXCL8, FLT3, KDR, MET 0.961
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 0.961
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, CHRNA7, GRIA4 2.2702
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.1297
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1297
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.1657
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.6849
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.6834
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.1882
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.752
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.1963
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.7208
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2066
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2119
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.7967
Influenza A_Homo sapiens_hsa05164 CXCL8 0.2066
Platelet activation_Homo sapiens_hsa04611 SRC, PTGS1 0.639
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.649
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.7962
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.649
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2119
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 0.8377
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.649
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.6368
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.5832
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.4219
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.7962
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.5996
Rheumatoid arthritis_Homo sapiens_hsa05323 CXCL8, MMP1 0.7962
Apoptosis_Homo sapiens_hsa04210 BCL2 0.2567
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.2567
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.6107
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.2555
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 CXCL8, PPARA 0.5504
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.6368
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.5892
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.5246
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.4685
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.4685
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.5832
Hepatitis C_Homo sapiens_hsa05160 CXCL8, PPARA 0.6107
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.4219
Chemokine signaling pathway_Homo sapiens_hsa04062 CXCL8, SRC 0.4528
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.8735
Axon guidance_Homo sapiens_hsa04360 MET 0.2803
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.2873
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.292
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 0.9842
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 0.967
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.8697
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 CXCL8 0.3287
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 CXCL8 0.332
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3389
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3386
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB2 0.9842
Amoebiasis_Homo sapiens_hsa05146 CXCL8 0.3389
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3468
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.3472
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3463
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 0.9401
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.3602
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.0623
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.3602
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.3602
Salmonella infection_Homo sapiens_hsa05132 CXCL8 0.3602
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3595
Shigellosis_Homo sapiens_hsa05131 CXCL8, SRC 0.9842
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.3588
Peroxisome_Homo sapiens_hsa04146 XDH 0.3674
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.0415
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4026
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4026
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4012
Pertussis_Homo sapiens_hsa05133 CXCL8 0.3997
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4109
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 CXCL8 0.4109
Malaria_Homo sapiens_hsa05144 CXCL8, MET 1.1492
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4109
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4219
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.4219
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.124
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4219
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.4233
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4219
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 CXCL8 0.4508
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.4528
Legionellosis_Homo sapiens_hsa05134 CXCL8 0.4528
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.497
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.4928
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.497
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5144
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.5504
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5005
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.3952
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.5126
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.3794
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.4622
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6107
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.628
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.649
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6189
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7007
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.639
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.7402
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.76
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.8377
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1104


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)