TCM Prescription: Feng Shi Ning Yao Wine



Prescription Description
Prescription IDTCMF3462
Pinyin NameFeng Shi Ning Yao Jiu
Chinese Name风湿宁药酒
English NameFeng Shi Ning Yao Wine
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH2238 Siegesbeckiae herba 豨莶草 TCMH2238 GQ434487
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH385 Sargentodoxa cuneata 大血藤 TCMH385 ITSAG360-14
TCMH37 Smilax china 菝葜 TCMH37 CPBOL4044-11
TCMH1247 Geranium wilfordii 老鹳草 TCMH1247 GBVT344-13
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH2195 Zaocys 乌梢蛇 TCMH2195
TCMH2185 Acanthopanax gracilistylus 五加皮 TCMH2185
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH201 Bombyx mori 蚕砂 TCMH201 AGIRI001-17
TCMH112 Dictamnus albus 白藓皮 TCMH112 GBVK982-11
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH2358 Aristolochia mollissima 寻骨风 TCMH2358 GBVE2068-11
TCMH672 Alpinia officinarum 高良姜 TCMH672 ITSAK2176-14
TCMH1798 Morus alba 桑枝 TCMH1798 ITSAL1073-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH206 Fructus xanthii sibirici 苍耳子 TCMH206 KJ496390
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT118 MGAM Maltase-glucoamylase Hydrolase O43451
TCMT124 FUCA1 Alpha-L-fucosidase I Hydrolase P04066
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT241 CHRNA7 Neuronal acetylcholine receptor protein alpha-7 subunit Ion channel P36544
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT347 MAN1B1 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Hydrolase Q9UKM7
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT552 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Ion channel P32297
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT605 EDNRA Endothelin receptor ET-A GPCR P25101
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT640 CTSD Cathepsin D Unclassified P07339
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT714 ODC1 Ornithine decarboxylase Lyase P11926
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1B1, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GAA, GBA, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, MIF, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, XDH 13.9987
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APEX1, APP, AXL, BCL2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, GBA, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTAFR, PTGES, PTGS2, SRC, TEK, TYR 13.5272
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GBA, GRIK5, GRM5, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTAFR, PTGES, PTGS2, SMAD3, SRC, TEK, TYR 13.1714
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSPA1A, MIF, PIK3CA, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, TYR, XDH 13.0724
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, APP, BCL2, CDC25B, CHRNA7, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FLT3, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PTAFR, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 12.9956
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, AKR1C3, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GBA, GRIK5, GRM5, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PTAFR, PTGES, PTGS2, SMAD3, SRC, TEK, TERT, TYR 12.1928
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GBA, GPR35, GRM1, HIF1A, HMGCR, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 12.1424
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GBA, GPR35, GRM1, HIF1A, HMGCR, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 12.1424
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GBA, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 12.1424
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GBA, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 11.9452
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APEX1, APP, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, GBA, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK 11.9429
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DUSP3, EDNRA, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GBA, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 11.5983
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GBA, GLO1, GRIK5, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 11.5983
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DUSP3, EDNRA, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GBA, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 11.5166
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, GBA, GPR35, GRM1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 11.0134
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, ESRRB, FABP3, FLT3, GBA, GRM1, GRM5, HIF1A, HMGCR, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.7777
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, ESRRB, FABP3, FLT3, GBA, GRM1, GRM5, HIF1A, HMGCR, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.7777
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7777
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP3, FABP4, FUCA1, FUT7, GBA, HMGCR, HSD17B1, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 10.6201
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, AKR1C3, APP, AXL, BCL2, CHRNA7, CYP1B1, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MIF, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 10.4138
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, AKR1C3, APP, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GPR35, GRM1, HIF1A, HMGCR, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 10.3754
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 10.3428
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GBA, GPR35, GRIK5, GRM1, GRM5, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 10.2769
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CHRNA7, EDNRA, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, GRIK5, GRM1, GRM5, HIF1A, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 10.1204
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.98905
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, APEX1, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GBA, INSR, PPARA, PTAFR, PTGS2, SRC, TEK 9.83521
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.77556
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GPR35, GRIK5, GRM1, GRM5, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.69895
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1C3, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EDNRA, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GBA, GRIK5, GRM1, GRM5, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TYR 9.6067
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DUSP3, EDNRA, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GBA, GRM1, GRM3, GRM5, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.49689
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, GBA, GRIK5, GRM5, HIF1A, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTAFR, PTGS2, SMAD3, SRC, TERT 9.20529
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.13787
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, BCL2, CDC25B, CHRNA7, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, HIF1A, HMGCR, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTAFR, PTGS2, TEK, TERT 8.99482
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, HIF1A, KDR, MMP9, PTGES, PTGS2, SRC, TERT 8.96305
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, AKR1C3, APP, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HIF1A, HMGCR, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.89519
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, AKR1C3, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GBA, GRM1, GRM5, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.83506
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AXL, BCL2, CACNA1C, CHRNA3, CHRNA7, CYP19A1, CYP1A2, CYP1B1, DUSP3, EDNRA, EGFR, ESR1, ESRRB, F3, FABP4, GAA, GBA, GRM1, GRM5, GRM8, HIF1A, HMGCR, HSD17B2, IGF1R, INSR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TYR 8.78444
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GBA, GRM1, GRM5, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.76714
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DUSP3, EDNRA, EGFR, ERBB2, ESR1, ESR2, F3, FABP4, FLT3, GBA, GPR35, GRM1, GRM3, GRM5, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.63802
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 8.40498
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, GBA, GRIK5, GRM5, HIF1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PTAFR, PTGS2, SMAD3, SRC 8.40498
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.40498
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, AKR1C3, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GBA, GRM1, GRM5, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.35659
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, GBA, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.34634
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, GBA, PTAFR, PTGES, PTGS2, SRC, TEK, TYR 8.2799
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, GBA, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.25862
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, EDNRA, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HIF1A, HSPA1A, INSR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.23448
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, AKR1C3, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TOP2A, TYR 8.21526
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, F3, HIF1A, IGF1R, INSR, KDR, MET, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 8.21394
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, ESRRB, FLT3, GRM1, GRM5, HIF1A, HMGCR, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.1175
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, F3, HIF1A, IGF1R, INSR, KDR, MET, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 8.1175
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, BCL2, CA2, CHRNA7, CYP1A1, EDNRA, EGFR, GBA, GRM1, HIF1A, HMGCR, HSPA1A, MMP2, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TYR 8.00349
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EDNRA, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HIF1A, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 7.97999
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, CHRNA3, CHRNA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 7.90713
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, CHRNA3, CHRNA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 7.90713
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MIF, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 7.88634
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, GBA, GRIK5, GRM1, GRM5, HIF1A, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NUAK1, PIK3CA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TERT, TOP2A 7.87904
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APEX1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CHRNA3, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, GPR35, GRIK5, GRM5, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.87527
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F3, HIF1A, IGF1R, INSR, KDR, MET, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 7.86981
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.85475
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, ERBB2, ESRRB, FABP4, FLT3, GBA, GRM1, GRM5, HIF1A, HMGCR, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 7.84147
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CHRNA7, EDNRA, EGFR, ESR1, FABP3, FABP4, GBA, GPR35, GRIK5, GRM1, GRM5, HIF1A, INSR, MET, PIK3CA, PIK3CB, SMAD3 7.81111
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.78414
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, EDNRA, EGFR, ERBB2, ESR1, F3, FLT3, GRM1, GRM5, HIF1A, HSPA1A, INSR, MIF, PIK3CA, PIK3CB, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.7343
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GBA, GRM1, GRM5, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.72917
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FUCA1, FUT7, GBA, HMGCR, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 7.65399
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GBA, HSD17B2, PTAFR, PTGES, PTGS2, SRC, TYR 7.63686
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GBA, GPR35, GRM1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.63686
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, F3, HIF1A, IGF1R, INSR, KDR, MET, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 7.56404
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.29795
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, CHRNA7, DUSP3, EGFR, ERBB2, FLT3, GBA, GRM1, HMGCR, IGF1R, INSR, MIF, PIK3CB, PTPN1, SRC 7.27834
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, GBA, GRM1, GRM5, HMGCR, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.19526
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, ERBB2, FABP4, FLT3, GBA, GRM1, GRM5, HMGCR, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 7.19526
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.09392
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 7.09392
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GBA, GPR35, GRM1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.08648
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, ERBB2, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 7.08648
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 7.07013
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, ERBB2, FABP4, FLT3, GBA, GRM1, GRM5, HMGCR, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC 6.9952
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, FABP4, FLT3, GBA, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.92972
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, APP, AXL, BCL2, CA2, CACNA1C, CHRNA3, CHRNA7, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, GAA, GBA, GPR35, GRM1, HIF1A, HMGCR, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTAFR, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, XDH 6.92166
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GBA, GLO1, GPR35, GRM3, GRM8, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.89761
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.85686
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 6.79448
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5, PTAFR 6.7738
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, EGFR, ERBB2, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 6.74833
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F3, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.74833
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, ERBB2, FABP4, FLT3, GBA, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.74833
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 6.65416
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, CHRNA3, CHRNA7, DUSP3, EGFR, ERBB2, FABP4, FLT3, GBA, GRM1, GRM5, HMGCR, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 6.58002
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F3, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.53979
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CHRNA3, CYP19A1, EGFR, ERBB2, GPR35, GRIK5, GRM5, HIF1A, HMGCR, HSPA1A, INSR, MIF, MMP12, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TERT 6.48344
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, PTGS1, PTGS2 6.48344
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F3, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.38113
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 6.25479
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALDH2, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DAO, GBA, HIF1A, HMGCR, PTAFR, TYR 6.2529
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 6.24749
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, PTGS1, PTGS2 6.24652
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 6.19643
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F3, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.19479
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, CHRNA7, DUSP3, EGFR, ERBB2, FLT3, GBA, GRM1, HMGCR, IGF1R, INSR, KDR, MIF, PIK3CB, PTPN1, SRC, TEK, XDH 6.18919
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, SMAD3, SRC, TEK 6.15699
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, GAA, HMGCR, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.13213
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 6.08921
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 6.0684
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 6.0684
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HMGCR, HSD17B1, HSD17B2 6.0684
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1C3, APEX1, APP, AXL, BCL2, CA2, CA9, CHRNA7, CYP1A1, CYP1A2, CYP1B1, EDNRA, EGFR, ERBB2, GBA, HIF1A, HSPA1A, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A 6.04537
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, AKR1C3, APP, AXL, BCL2, CA1, CA2, CACNA1C, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DNMT1, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HIF1A, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTPN1, SMAD3, SRC, TEK 5.97937
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GBA, GLO1, GPR35, GRM3, GRM8, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.96482
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, CHRNA7, EGFR, ERBB2, FLT3, GRM1, HMGCR, INSR, KDR, MIF, PIK3CB, PTPN1, SRC, TEK, XDH 5.95535
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, APP, AXL, CYP1B1, DNMT1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTAFR, PTGS2, SRC 5.8902
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, ESR1, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 5.8902
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, APP, AXL, BCL2, CA2, CHRNA7, CYP1B1, EGFR, ESRRB, F3, GBA, HIF1A, HMGCR, HSPA1A, KDR, MET, MIF, MMP12, MMP9, PIM1, PTAFR, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT 5.8661
[BP] GO:0010038 response to metal ion AKR1C3, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, HIF1A, MMP9, PTGES, PTGS2, TERT 5.83709
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 5.76778
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, CHRNA3, CHRNA7, GBA, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 5.59763
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.55404
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GBA, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.5355
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.52463
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 5.51108
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CSNK2A1, CYP19A1, CYP1A1, GBA, HMGCR, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 5.51108
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 5.49092
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, ALDH2, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 5.48648
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS2, PTPN1, SRC, TEK, XDH 5.44831
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3, FUCA1, GBA 5.42968
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRB1, AKR1C3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GLO1, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.41178
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 5.39651
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 5.37387
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CHRNA3, CHRNA7, DNMT1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, PTGS2, SRC, TEK, TYR 5.35135
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CHRNA3, CHRNA7, CYP1A1, CYP1B1, EGFR, FABP3, GBA, HMGCR, KDR, PTAFR, PTGS2, SRC 5.3379
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRB1, AKR1C3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GLO1, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.32524
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EDNRA, EGFR, ERBB2, ESR1, FLT3, MET, MIF, PIK3CB, PIM1, SRC, TEK, TYR 5.32072
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.30614
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, CHRNA7, DUSP3, EGFR, ERBB2, FLT3, GBA, GRM1, HMGCR, IGF1R, INSR, MIF, PIK3CB, PTPN1, SRC 5.26331
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CACNA1C, CHRNA3, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HIF1A, HMGCR, HSD17B1, HSD17B2 5.19847
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, CHRNA7, EDNRA, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, HIF1A, PIK3CB, SMAD3 5.18907
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APEX1, APP, AURKB, BCL2, CHRNA7, CSNK2A1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ESR1, ESR2, ESRRA, FABP4, GBA, GRM3, GRM8, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 5.17255
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC 5.15089
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CHRNA7, DNMT1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, PTGS2, SRC, TEK, TYR 5.14276
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APEX1, APP, DNMT1, EGFR, ERBB2, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, PTAFR, PTGS2, SMAD3, SRC 5.0701
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, AKR1C3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GLO1, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.05976
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, CHRNA3, CHRNA7, EGFR, ERBB2, FLT3, GRM1, GRM5, INSR, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.05703
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS2, PTPN1, SRC, TEK, XDH 5.05117
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA2, CACNA1C, CHRNA3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, GAA, HIF1A, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 5.04589
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.99591
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.98844
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.98844
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRB1, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GLO1, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.9813
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, CACNA1C, CHRNA7, EDNRA, ESR1, GAA, GPR35, GRIK5, GRM1, GRM5, HIF1A, PIK3CA, PIK3CB, SMAD3 4.95166
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTAFR, PTGES, PTGS2, SRC 4.93995
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, EGFR, FLT3, GBA, PTAFR, PTGS2, SRC 4.91504
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, PTGS1, PTGS2 4.91504
[BP] GO:0003018 None ADORA1, ADRB1, EDNRA, EGFR, HMGCR, PTAFR, PTGS2, SRC, TEK 4.91504
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, CHRNA7, EGFR, ERBB2, FLT3, GRM1, INSR, MIF, PIK3CB, PTPN1, SRC 4.88528
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 4.88059
[BP] GO:0060078 None ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM5 4.80542
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, EGFR, HIF1A, HMGCR, KDR, MIF, PIK3CB, PTGS2, SRC 4.79751
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, CHRNA7, DUSP3, EGFR, ERBB2, HMGCR, KDR, MIF, PTPN1, SRC, TEK 4.73418
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, CHRNA7, EDNRA, EGFR, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, SMAD3 4.72585
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APEX1, APP, AURKB, BCL2, CHRNA7, CSNK2A1, DNMT1, DUSP3, DYRK1A, EDNRA, ESR1, ESR2, ESRRA, FABP4, GBA, GRM3, GRM8, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 4.71414
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, BCL2, CA2, EGFR, FLT3, GBA, PTAFR, PTGS2, SRC 4.67869
[BP] GO:0006693 None AKR1C3, MIF, PTGES, PTGS1, PTGS2 4.66453
[BP] GO:0006692 None AKR1C3, MIF, PTGES, PTGS1, PTGS2 4.66453
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRIK5, GRM1, GRM5, HIF1A, PIK3CA, PIK3CB, SMAD3 4.64199
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5, MIF, PTAFR 4.64199
[BP] GO:0019371 None AKR1C3, PTGES, PTGS1, PTGS2 4.64199
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, EGFR, HIF1A, INSR, PTGS2, SMAD3, XDH 4.63254
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, CHRNA7, FABP3, GRM5, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 4.6104
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTAFR, PTGS2, SRC 4.58594
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GBA, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.58456
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 4.58456
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.57681
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 4.54199
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 4.49331
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 4.48548
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGES, PTGS1, PTGS2 4.44659
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, ERBB2, HIF1A, INSR, MIF, MMP12, PTAFR, PTGS2, SMAD3, SRC, TERT 4.40643
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, CACNA1C, CHRNA3, EGFR, GAA, GBA, GPR35, GRM1, PTAFR, PTGS2, SLC1A1, SMAD3 4.38973
[BP] GO:0003008 None ADORA1, ADRB1, AKR1B1, AKR1C3, APP, BCL2, CHRNA7, CYP1B1, EDNRA, EGFR, GAA, GRM1, GRM5, GRM8, HIF1A, HMGCR, INSR, PIK3CA, PTAFR, PTGS2, SRC, TEK, TYR 4.38711
[BP] GO:0001516 None MIF, PTGES, PTGS1, PTGS2 4.34923
[BP] GO:0046457 None MIF, PTGES, PTGS1, PTGS2 4.34923
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.33934
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.29396
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.2166
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.1778
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, CHRNA7, EDNRA, EGFR, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, SMAD3 4.16335
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 4.15958
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 4.11852
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 4.11182
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, GRM5, IGF1R, INSR, MMP2, PTAFR, PTGS2, SRC 4.09779
[BP] GO:0008217 None ADORA1, ADRB1, EDNRA, PPARA, PTAFR, PTGS1, PTGS2, SMAD3 4.03519
[BP] GO:0032787 None AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, HIF1A, MIF, PPARA, PTGES, PTGS1, PTGS2 4.02402
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, DYRK1A, EGFR, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MIF, NUAK1, PTGS2, PTPN1, TERT, XDH 4.00012
[BP] GO:0003013 None ADORA1, ADRB1, EDNRA, EGFR, HMGCR, PTAFR, PTGS2, SRC, TEK 3.99676
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, SMAD3 3.97476
[BP] GO:0044236 multicellular organism metabolic process ADRB1, AKR1C3, HIF1A, MMP1, MMP12, MMP2, MMP9 3.9569
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, MIF, PTGES, PTGS1, PTGS2 3.95321
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, FUCA1, GBA 3.94341
[BP] GO:0045766 positive regulation of angiogenesis CHRNA7, CYP1B1, F3, HIF1A, KDR, PTGS2, TEK, TERT 3.94341
[BP] GO:0045913 None ESRRB, HIF1A, INSR, PPARA, PTAFR, SRC 3.92807
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.91695
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC, TERT 3.91435
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1, HMGCR 3.90442
[BP] GO:0060079 None ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.90442
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, CACNA1C, CHRNA7, EDNRA, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 3.88235
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 3.88235
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, SMAD3 3.88197
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GBA, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.85712
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUCA1, FUT7, GAA, HSPA1A, MGAM, MIF, MMP9, PIK3CA, PIK3CB, PTAFR, SMAD3, SRC 3.85069
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, CYP19A1, DAO, GBA, HMGCR, PTAFR, TYR 3.81067
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, CHRNA7, EGFR, ERBB2, FLT3, GRM1, INSR, MIF, PIK3CB, PTPN1, SRC 3.81067
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EDNRA, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 3.80867
[BP] GO:0007154 None ADORA1, ADRB1, AKR1C3, AXL, BCL2, CACNA1C, CHRNA3, ESR2, GBA, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1, TEK 3.7977
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, GRM5, IGF1R, INSR, MMP2, PTAFR, PTGS2, SRC 3.79238
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, AKR1C3, ALPL, APP, AXL, BCL2, CDC25B, CHRNA7, CYP1A1, EDNRA, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, HIF1A, HMGCR, KDR, MET, MIF, MMP2, MMP9, PTGS2, SMAD3, SRC, TEK, TERT, TOP2A 3.78345
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HIF1A, HSD17B2, INSR, PTGS2, SRC 3.73699
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, F3, FABP4, GBA, HMGCR, KDR, MET, MIF, MMP12, PPARA, PTGS2, SMAD3, TEK 3.728
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX5, CYP19A1, CYP1A1, GBA, HMGCR, MIF, PTAFR, PTGES, PTGS1, PTGS2 3.68668
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CACNA1C, CHRNA3, GPR35, GRM5, MIF, MMP9, PTAFR, PTGS2 3.66831
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, CHRNA7, EGFR, PTGS2 3.62859
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, SRC, TERT 3.59994
[BP] GO:1904018 positive regulation of vasculature development CHRNA7, CYP1B1, F3, HIF1A, KDR, PTGS2, TEK, TERT 3.58346
[BP] GO:0097746 None ADORA1, ADRB1, EDNRA, EGFR, HMGCR, PTAFR, PTGS2 3.56401
[BP] GO:0035296 None ADORA1, ADRB1, EDNRA, EGFR, HMGCR, PTAFR, PTGS2 3.56401
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR 3.54704
[BP] GO:0010634 positive regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 3.54704
[BP] GO:0007610 None APP, BCL2, CHRNA3, CHRNA7, EGFR, GAA, GRM1, GRM5, HIF1A, HMGCR, INSR, PPARA, PTGS2 3.5316
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, GBA, HIF1A, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 3.52899
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, ERBB2, PPARA, SMAD3 3.52466
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 3.50659
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.50084
[BP] GO:0055065 metal ion homeostasis APP, BCL2, CACNA1C, CHRNA7, EDNRA, EGFR, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, SMAD3 3.49576
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HIF1A, HSD17B2, INSR, MMP2, MMP9, PTAFR, PTGS2, SRC, TOP2A 3.48674
[BP] GO:0032147 activation of protein kinase activity ADORA1, CHRNA3, CHRNA7, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.43891
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.43249
[BP] GO:0050880 None ADORA1, ADRB1, EDNRA, EGFR, HMGCR, PTAFR, PTGS2 3.41444
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.41444
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, HIF1A, MMP1, MMP12, MMP2, MMP9 3.41444
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 3.40079
[BP] GO:0035150 None ADORA1, ADRB1, EDNRA, EGFR, HMGCR, PTAFR, PTGS2 3.39834
[BP] GO:0051172 None APEX1, APP, AURKB, CHRNA7, CSNK2A1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ESR1, ESR2, ESRRA, FABP4, GBA, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 3.39377
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 3.35597
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.34181
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CHRNA3, CYP1B1, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SMAD3 3.3343
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A 3.32339
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GBA, GLO1, GRM1, GRM5, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.32339
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DAO, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, FUCA1, FUT7, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.32339
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CHRNA7, CYP1A1, CYP1B1, HMGCR, KDR, SRC 3.32339
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, PTGS2, SMAD3, XDH 3.31996
[BP] GO:0010676 None ESRRB, INSR, PPARA, PTAFR, SRC 3.31996
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, CACNA1C, CHRNA7, EDNRA, ESR1, GPR35, GRM1, GRM5, HIF1A, PIK3CB, SMAD3 3.31247
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.30844
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.30844
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.30844
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, GBA, PTAFR, PTGS2 3.29866
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, GLO1, HIF1A, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 3.2959
[BP] GO:1901342 regulation of vasculature development CHRNA7, CYP1B1, ERBB2, F3, HIF1A, KDR, PTGS2, TEK, TERT, XDH 3.28321
[BP] GO:0035556 intracellular signal transduction ADRB1, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DNMT1, EGFR, ERBB2, GRM5, IGF1R, INSR, KDR, MET, MIF, NUAK1, PIK3CA, PIK3CB, PTAFR, PTPN1, SRC, TEK 3.28188
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, CHRNA7, EGFR, HMGCR, KDR, MIF, SRC, TEK 3.27689
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRNA3, CHRNA7, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 3.24098
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.22985
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 3.21264
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9, TERT 3.19064
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, ALDH2, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MGAM, XDH 3.17855
[BP] GO:0050793 regulation of developmental process ADRB1, APP, AXL, BCL2, CA2, CHRNA3, CHRNA7, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, HIF1A, HMGCR, INSR, KDR, MIF, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, XDH 3.17152
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.17152
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, BCL2, CA2, CA9, CACNA1C, CHRNA7, CYP1B1, EDNRA, EGFR, ESR1, GAA, GBA, HIF1A, INSR, MET, MMP2, SMAD3, SRC, TEK 3.17152
[BP] GO:0010359 None ABCB1, GRM5, PTAFR 3.16684
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.16684
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, PTGS2, SMAD3, SRC, TERT, TOP2A 3.16126
[BP] GO:0050890 None ADORA1, APP, CHRNA7, EGFR, GRM5, HIF1A, HMGCR, INSR, PTGS2 3.16126
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.15538
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.14881
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 3.1306
[BP] GO:0006066 None AKR1B1, AKR1B10, AKR1C3, ALDH2, APP, CYP1B1, GBA, HMGCR, PTAFR 3.11814
[BP] GO:1901214 regulation of neuron death AXL, BCL2, CHRNA7, GBA, GRIK5, HIF1A, PIK3CA, PPARA, TERT 3.09685
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CYP1A1, EGFR, GBA, HMGCR, PTGS2, SRC, TYR 3.08909
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CHRNA3, CHRNA7, CSNK2A1, DNMT1, EGFR, ERBB2, ESR1, ESR2, GBA, GRIK5, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, SMAD3, SRC, TEK, TOP2A 3.08898
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CYP1B1, F3, GRIK5, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 3.08284
[BP] GO:0048731 system development ACHE, ADORA1, ALPL, CACNA1C, CHRNA3, DYRK1A, EDNRA, ERBB2, HIF1A, MMP9, PIK3CA, SMAD3, SRC, TEK 3.07461
[BP] GO:0006636 unsaturated fatty acid biosynthetic process MIF, PTGES, PTGS1, PTGS2 3.07425
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EDNRA, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 3.06988
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, PTAFR, PTGS2, SRC 3.0584
[BP] GO:0035239 tube morphogenesis BCL2, EDNRA, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 3.05135
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.05135
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CYP1B1, F3, GRIK5, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 3.04861
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD17B1, HSD17B2 3.04782
[BP] GO:0048015 phosphatidylinositol-mediated signaling ERBB2, IGF1R, PIK3CA, PIK3CB, PTAFR 3.04782
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.04529
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, PPARA, SRC, TOP2A 3.04233
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DNMT1, GBA, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.03961
[BP] GO:1903522 None ADORA1, ADORA3, ADRB1, CACNA1C, EGFR, GAA, PTAFR, PTGS2, SLC1A1 3.03256
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3, HMGCR 3.02917
[BP] GO:1904645 response to amyloid-beta APP, CHRNA7, GRM5, IGF1R 3.02917
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, EGFR, ERBB2, HIF1A, HMGCR, MIF, MMP12, PTGS2, PTPN1, SMAD3, SRC 3.02356
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALDH2, AOX1, CYP1A1, CYP1A2, CYP1B1, DAO, EGFR, HSPA1A 3.02356
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.01024
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CYP1A1, FABP3, FLT3, HMGCR, PPARA, PTGS2, SRC, TEK 3.00756
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 2.98007
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling ERBB2, IGF1R, PIK3CA, PIK3CB 2.98007
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR 2.97882
[BP] GO:0048017 inositol lipid-mediated signaling ERBB2, IGF1R, PIK3CA, PIK3CB, PTAFR 2.96495
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.95804
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.95019
[BP] GO:0045765 regulation of angiogenesis CHRNA7, CYP1B1, ERBB2, F3, HIF1A, KDR, PTGS2, TEK, TERT 2.91041
[BP] GO:1902893 None HIF1A, PPARA, SMAD3, TERT 2.88281
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.88281
[BP] GO:0106027 None APP, CHRNA7, IGF1R, INSR 2.88281
[BP] GO:0010863 positive regulation of phospholipase C activity EDNRA, EGFR, ESR1, PTAFR 2.88281
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, AKR1C3, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRNA3, CHRNA7, EDNRA, EGFR, FABP3, FUCA1, GAA, GRIA2, GRIA4, GRIK5, HIF1A, HSPA1A, MGAM, MIF, MMP12, MMP9, PPARA, PTAFR, SLC1A1, SRC, TERT, XDH 2.87713
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.87566
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PTGS2, SMAD3, SRC, TERT, TOP2A 2.86984
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, MIF, PTPN1, SRC 2.86779
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, MIF, PTGS2, TERT 2.86779
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, GLO1, HIF1A, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 2.86026
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT 2.85978
[BP] GO:0016488 None AKR1B10, AKR1C3 2.85978
[BP] GO:0016487 None AKR1B10, AKR1C3 2.85978
[BP] GO:0016107 None AKR1B10, AKR1C3 2.85978
[BP] GO:0009115 None AOX1, XDH 2.85978
[BP] GO:0006714 None AKR1B10, AKR1C3 2.85978
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, ESR1, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.85923
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DUSP3, ERBB2, ESR1, ESRRA, HIF1A, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PTAFR, PTPN1, SMAD3, SRC 2.85413
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 2.85413
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, GBA, HIF1A, IGF1R, INSR, MET, MMP12, PPARA, PTAFR, PTGS2, SMAD3, SRC, TERT, TOP2A 2.85413
[BP] GO:1900542 None ADRB1, EDNRA, ESRRB, GRM3, GRM8, HIF1A, INSR, PPARA 2.84371
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, GBA, PPARA, SMAD3, TEK 2.83666
[BP] GO:0007611 None APP, CHRNA7, EGFR, GRM5, HIF1A, HMGCR, INSR, PTGS2 2.83362
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, GBA, MMP12, PPARA, SMAD3, TEK 2.83243
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, ALDH2, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FABP4, FUCA1, GAA, GBA, HSPA1A, MGAM, PIK3CB, SRC, XDH 2.82884
[BP] GO:0040008 regulation of growth ADRB1, APP, BCL2, CSNK2A1, EGFR, ERBB2, ESR2, HIF1A, HSPA1A, INSR, PIK3CA, PIM1, SMAD3 2.82269
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.81929
[BP] GO:0031644 None ADORA1, GBA, GPR35, GRM1, PTAFR 2.81672
[BP] GO:1903524 None ADRB1, EGFR, PTAFR, PTGS2, SLC1A1 2.81672
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, PPARA, PTGS2, SMAD3, TEK 2.80911
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4, FUCA1, GBA 2.80725
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, GLO1, HIF1A, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 2.79428
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, GBA, MET, PIK3CA 2.78676
[BP] GO:0050679 None EGFR, ERBB2, F3, HIF1A, KDR, MMP12, TEK 2.78138
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 2.78138
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CYP1B1, F3, GRIK5, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.78023
[BP] GO:0006140 None ADRB1, EDNRA, ESRRB, GRM3, GRM8, HIF1A, INSR, PPARA 2.7727
[BP] GO:1900274 regulation of phospholipase C activity EDNRA, EGFR, ESR1, PTAFR 2.7727
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.77037
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.76313
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.7484
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, GBA, PTAFR, SRC 2.74219
[BP] GO:0030155 regulation of cell adhesion BCL2, CYP1B1, DUSP3, ERBB2, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, SMAD3, SRC, TEK 2.73436
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 2.70648
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 2.70306
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, DAO, GBA 2.69046
[BP] GO:0060341 regulation of cellular localization APP, BCL2, CACNA1C, CHRNA3, CSNK2A1, EGFR, ERBB2, GRIK5, HIF1A, HMGCR, PTGS2, PTPN1, SMAD3, SRC, TERT 2.68224
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CYP1A1, EGFR, GBA, HMGCR, PTGS2, SRC, TYR 2.67856
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.6723
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CHRNA3, CYP19A1, EGFR, GRIK5, HIF1A, HMGCR, MIF, MMP12, PTAFR, SRC 2.66126
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.66083
[BP] GO:0038128 None EGFR, ERBB2, PIK3CA, SRC 2.65426
[BP] GO:0097756 None ADORA1, EDNRA, HMGCR, PTGS2 2.65426
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.65391
[BP] GO:1901215 negative regulation of neuron death AXL, BCL2, GBA, HIF1A, PIK3CA, PPARA, TERT 2.64004
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, APP, AURKB, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TERT, TOP2A 2.63294
[BP] GO:0050678 None EGFR, ERBB2, F3, HIF1A, KDR, MMP12, SMAD3, TEK, XDH 2.62815
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, AKR1C3, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRNA3, CHRNA7, EDNRA, EGFR, ESR1, FABP3, FUCA1, GAA, GRIA2, GRIA4, GRIK5, HIF1A, HSPA1A, MGAM, MIF, MMP12, MMP9, PPARA, PTAFR, SLC1A1, SRC, TERT, XDH 2.62729
[BP] GO:0001525 angiogenesis CYP1B1, HIF1A, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.61636
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.58829
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTAFR, PTGS2, TEK, TYR 2.58829
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.58829
[BP] GO:0070542 None AKR1C3, FABP3, PTAFR, PTGS2, SRC 2.58319
[BP] GO:1901570 None ALOX5, MIF, PTGES, PTGS1, PTGS2 2.58319
[BP] GO:0034310 None AKR1B10, AKR1C3, ALDH2 2.58319
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.58319
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.58319
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 2.57523
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 2.57086
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CHRNA7, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 2.56583
[BP] GO:0032963 collagen metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.56329
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CYP1A1, EGFR, HMGCR, PTGS2, TYR 2.55703
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CYP1B1, ERBB2, FABP3, HSPA1A, PTGES, PTGS2, SMAD3, TERT, XDH 2.55225
[BP] GO:0045776 None ADORA1, ADRB1, PPARA, PTAFR 2.5487
[BP] GO:0071229 cellular response to acid chemical AKR1C3, DNMT1, EGFR, KDR, MMP2, PTAFR, SRC 2.54558
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HIF1A, MIF, PIK3CB 2.54335
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.54335
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTAFR, SRC, TEK 2.54335
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, EGFR, ERBB2, HIF1A, MIF, MMP12, PTGS2, SMAD3, SRC 2.52964
[BP] GO:0032880 regulation of protein localization ACHE, APP, BCL2, CACNA1C, CSNK2A1, EGFR, ERBB2, HIF1A, HMGCR, MIF, MMP12, PTGS2, PTPN1, SMAD3, SRC, TERT 2.52519
[BP] GO:0051248 None APP, CHRNA7, CSNK2A1, DNMT1, DUSP3, EGFR, FABP4, GBA, HMGCR, HSPA1A, IGF1R, MIF, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 2.5249
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT 2.52458
[BP] GO:0001816 cytokine production APP, FABP4, HIF1A, PTAFR, PTGS2 2.52324
[BP] GO:0001961 None AXL, HIF1A, HSPA1A, MMP12 2.5178
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.5178
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CHRNA7, CYP1B1, ESRRB, F3, HIF1A, HMGCR, INSR, KDR, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 2.5162
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.5162
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.5162
[BP] GO:0070920 None EGFR, ESR1, TERT 2.5162
[BP] GO:0048546 None BCL2, EGFR, HIF1A 2.5162
[BP] GO:0007612 None APP, GRM5, HIF1A, HMGCR, INSR, PTGS2 2.50709
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.50709
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.48756
[BP] GO:0010595 positive regulation of endothelial cell migration HIF1A, KDR, MET, PTGS2, TEK 2.48425
[BP] GO:0001817 regulation of cytokine production AXL, CHRNA7, CYP1B1, GBA, HIF1A, HSPA1A, MIF, MMP12, PTAFR, PTGS2, SMAD3, SRC 2.48313
[BP] GO:0099566 None GRM1, GRM5 2.48313
[BP] GO:0000023 None GAA, MGAM 2.48313
[BP] GO:0046110 None AOX1, XDH 2.48313
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48313
[BP] GO:1905144 None CHRNA3, CHRNA7 2.48313
[BP] GO:0002520 None CACNA1C, SMAD3 2.48313
[BP] GO:0016095 None AKR1B10, AKR1C3 2.48313
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, MIF, PIK3CA, PIK3CB, PTAFR, PTGES, PTGS1, PTGS2 2.47721
[BP] GO:0070201 None ACHE, APP, BCL2, CACNA1C, EGFR, ERBB2, HIF1A, HMGCR, MIF, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.47536
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, GBA, HIF1A, HSPA1A, MIF, MMP9, NUAK1, PTGS2, PTPN1, SRC, TERT, TOP2A 2.4589
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, SMAD3, SRC, TERT, TOP2A 2.43028
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRB1, AKR1C3, APP, CA2, EDNRA, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, INSR, PIK3CA, PIK3CB, PTAFR, SRC 2.42785
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.42022
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.4182
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, GBA, HMGCR, MIF, PPARA, SMAD3, TEK 2.40962
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, KDR, MET, MIF, PTGS2, SMAD3 2.40962
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, ESRRB, GBA, HIF1A, HSPA1A, INSR, KDR, PIK3CB, PPARA, PTPN1 2.40575
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CHRNA3, CYP19A1, EGFR, GRIK5, HIF1A, HMGCR, MIF, MMP12, PTAFR, SRC 2.40489
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, AKR1C3, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRNA3, CHRNA7, EDNRA, FABP3, FUCA1, GAA, GRIA2, GRIA4, GRIK5, HIF1A, HSPA1A, MGAM, MIF, MMP12, MMP9, PPARA, PTAFR, SLC1A1, SRC, XDH 2.40062
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, INSR, SRC 2.39935
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC 2.39935
[BP] GO:2000107 negative regulation of leukocyte apoptotic process AURKB, AXL, HIF1A, MIF 2.39935
[BP] GO:0060760 None AXL, HIF1A, HSPA1A, MMP12 2.39935
[BP] GO:0045821 None ESRRB, HIF1A, INSR 2.38705
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTAFR, PTGS2, TEK, TYR 2.36917
[BP] GO:2000026 regulation of multicellular organismal development APP, AXL, BCL2, CA2, CHRNA3, CHRNA7, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F3, HIF1A, HMGCR, INSR, KDR, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 2.3602
[BP] GO:0051336 regulation of hydrolase activity ADRB1, APP, CSNK2A1, EDNRA, EGFR, ERBB2, ESR1, F3, HSPA1A, MMP9, NUAK1, PTAFR, PTGS2, PTPN1, SMAD3, SRC, XDH 2.35785
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, EGFR, HIF1A, HMGCR, PTGS2, TYR 2.35785
[BP] GO:2000351 None AKR1C3, KDR, TEK, TERT 2.33604
[BP] GO:0010518 positive regulation of phospholipase activity EDNRA, EGFR, ESR1, PTAFR 2.33604
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRB1, AKR1C3, APEX1, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GBA, GLO1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TERT, TOP2A 2.32995
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.32525
[BP] GO:0051197 None ESRRB, HIF1A, INSR 2.32525
[BP] GO:0010632 regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 2.32354
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.32354
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.31182
[BP] GO:0051591 None APEX1, APP, PTAFR, TEK, TYR 2.27516
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.26257
[BP] GO:0001892 None EGFR, ESRRB, HIF1A 2.26257
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR 2.25783
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.24729
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, ADRB1, APP, AXL, BCL2, CHRNA7, EGFR, ERBB2, GBA, GPR35, HIF1A, PTGS2, SMAD3, TEK, TERT, XDH 2.23072
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HIF1A, MIF, MMP12, PTAFR, SRC 2.23037
[BP] GO:0007188 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.23037
[BP] GO:0098908 None GBA, GPR35 2.22839
[BP] GO:0006145 None AOX1, XDH 2.22839
[BP] GO:1901529 None ABCB1, PTAFR 2.22839
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22839
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.22683
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.22683
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.21181
[BP] GO:1903959 None ABCB1, GRM5, PTAFR 2.21181
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.21181
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HIF1A, PIK3CB, PTGS2 2.20961
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.19768
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.19768
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.19427
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.19427
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.19427
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.19427
[BP] GO:0022898 None ABCB1, APP, BCL2, GPR35, GRM5, MMP9, PTAFR 2.19205
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.17641
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, ERBB2, HIF1A, MIF, MMP12, PTGS2, SMAD3, SRC 2.17641
[BP] GO:0051223 None ACHE, APP, CACNA1C, EGFR, ERBB2, HIF1A, HMGCR, MIF, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.17316
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, ESRRB, GBA, HIF1A, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1 2.16922
[BP] GO:0050877 None ADORA1, APP, CHRNA7, CYP1B1, EGFR, GAA, GRM1, GRM5, GRM8, HIF1A, HMGCR, INSR, PTGS2, TYR 2.16797
[BP] GO:1902895 None HIF1A, SMAD3, TERT 2.16385
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.16385
[BP] GO:0051194 None ESRRB, HIF1A, INSR 2.16385
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.16385
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, HIF1A, HSPA1A, MIF, MMP12, PTAFR, PTGS2, SMAD3, SRC 2.14741
[BP] GO:0031331 positive regulation of cellular catabolic process ESRRB, GBA, HIF1A, HSPA1A, INSR, KDR, PIK3CB, PPARA, PTPN1 2.14741
[BP] GO:0071456 cellular response to hypoxia BCL2, HIF1A, PTGS2, SRC, TERT 2.14497
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.12385
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.12385
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.11413
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.11272
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.11272
[BP] GO:0022603 regulation of anatomical structure morphogenesis BCL2, CHRNA3, CHRNA7, CYP1B1, ERBB2, ESR1, F3, HIF1A, KDR, PIM1, PTGS2, SRC, TEK, TERT, XDH 2.10444
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, HIF1A, KDR, TEK, TYR 2.10444
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.10444
[BP] GO:0034308 None AKR1B10, AKR1C3, ALDH2, CYP1B1 2.10024
[BP] GO:0045936 None DUSP3, EDNRA, FABP4, GBA, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.09174
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.08687
[BP] GO:0010563 None DUSP3, EDNRA, FABP4, GBA, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.08687
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, INSR 2.08132
[BP] GO:0010517 regulation of phospholipase activity EDNRA, EGFR, ESR1, PTAFR 2.07622
[BP] GO:0023052 None ADORA1, ADRB1, CACNA1C, CHRNA3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 2.07622
[BP] GO:0051894 None KDR, SMAD3, TEK 2.06646
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.06646
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.06646
[BP] GO:0032409 None ABCB1, APP, BCL2, GPR35, GRM5, MMP9, PTAFR 2.0604
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.04863
[BP] GO:0010641 None F3, SRC 2.04863
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, MIF, PTPN1, SRC 2.03571
[BP] GO:0036294 cellular response to decreased oxygen levels BCL2, HIF1A, PTGS2, SRC, TERT 2.03571
[BP] GO:0046834 lipid phosphorylation EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.03571
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, ERBB2, INSR, KDR, SMAD3, SRC 2.03412
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.03011
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, FUCA1, GAA, HIF1A, HSPA1A, MGAM, MIF, MMP9, PTAFR, SLC1A1, XDH 2.02615
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, HIF1A, INSR, PPARA, PTAFR, SRC 2.02508
[BP] GO:0050927 None F3, KDR, SMAD3 2.02343
[BP] GO:0060193 positive regulation of lipase activity EDNRA, EGFR, ESR1, PTAFR 2.00627
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, CHRNA3, CHRNA7, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, MGAM, PTGS2, SLC1A1, SRC, TEK 6.85686
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRNA3, CHRNA7, CSNK2A1, EDNRA, EGFR, ERBB2, ESR1, F3, FLT3, GAA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTPN1, SLC1A1, SMAD3, SRC, TEK, TERT 6.46967
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRB1, APP, AXL, BACE1, CA2, CA4, CA9, CACNA1C, CHRNA3, CHRNA7, DUSP3, EDNRA, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MGAM, PTAFR, PTGS2, SLC1A1, SRC, TEK 6.13213
[CC] GO:0043235 receptor complex APP, CHRNA3, CHRNA7, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 4.93995
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GRIA4, GRIK5, GRM1, GRM5, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MGAM, MIF, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TERT, TOP2A, TYR, XDH 4.56805
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CHRNA3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MGAM, MIF, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TERT, TOP2A, TYR, XDH 4.41081
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EDNRA, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, INSR, KDR, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TEK, TERT, TYR 4.33675
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, BACE1, CA4, EDNRA, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, TEK 3.9966
[CC] GO:0045121 membrane raft APP, BACE1, CHRNA3, CHRNA7, EGFR, INSR, KDR, PTGS2, SRC, TEK 3.67305
[CC] GO:0098857 membrane microdomain APP, BACE1, CHRNA3, CHRNA7, EGFR, INSR, KDR, PTGS2, SRC, TEK 3.64991
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.30844
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, BACE1, EDNRA, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, TEK 3.29553
[CC] GO:0014069 None ADORA1, CACNA1C, CHRNA3, GRIK5, GRM1, GRM3, GRM5, SRC 3.26347
[CC] GO:0099572 None ADORA1, CACNA1C, CHRNA3, GRIK5, GRM1, GRM3, GRM5, SRC 3.26347
[CC] GO:1903561 None ABCB1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, CA6, DUSP3, F3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRIA4, GRM5, HSPA1A, INSR, MGAM, MIF, MMP9, NQO2, PTGS1, SLC1A1, SRC 3.20285
[CC] GO:0043230 None ABCB1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, CA6, DUSP3, F3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRIA4, GRM5, HSPA1A, INSR, MGAM, MIF, MMP9, NQO2, PTGS1, SLC1A1, SRC 3.20249
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EDNRA, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, INSR, KDR, MET, MGAM, PIK3CA, PIK3CB, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TEK, TYR 3.19558
[CC] GO:0031982 None ABCB1, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALPL, AOX1, APP, AXL, BACE1, CA1, CA2, CA4, CA6, DUSP3, EGFR, F3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRIA4, GRM5, HSPA1A, INSR, KDR, MGAM, MIF, MMP9, NQO2, PTGS1, PTPN1, SLC1A1, SRC, TYR 3.17152
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DUSP3, EGFR, ERBB2, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GRIA2, GRIA4, GRIK5, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MGAM, MIF, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TERT, TOP2A, TYR, XDH 3.14881
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 3.11916
[CC] GO:0098589 membrane region APP, BACE1, CHRNA3, CHRNA7, EGFR, INSR, KDR, PTGS2, SRC, TEK 3.07563
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.02356
[CC] GO:0097060 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 3.01543
[CC] GO:0070062 None ABCB1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, CA6, DUSP3, F3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRM5, HSPA1A, INSR, MGAM, MIF, MMP9, NQO2, PTGS1, SLC1A1, SRC 2.95019
[CC] GO:0044421 None ABCB1, ACHE, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, CA6, DUSP3, EGFR, ESRRA, F3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, GRIA4, GRM5, HSPA1A, INSR, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PTGS1, SLC1A1, SRC, XDH 2.8765
[CC] GO:0098802 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, INSR 2.79326
[CC] GO:0031974 None ALDH2, ALOX5, APP, BACE1, CA5A, CA5B, DAO, EGFR, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MIF, MMP9, PTGES, PTGS2 2.73418
[CC] GO:0043233 None ALDH2, ALOX5, APP, BACE1, CA5A, CA5B, DAO, EGFR, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MIF, MMP9, PTGES, PTGS2 2.73418
[CC] GO:0070013 None ALDH2, ALOX5, APP, BACE1, CA5A, CA5B, DAO, EGFR, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MIF, MMP9, PTGES, PTGS2 2.73418
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2, TEK 2.64004
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, EGFR, F3, MET, MIF, TEK 2.37424
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CACNA1C, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MIF, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 2.37375
[CC] GO:0044853 plasma membrane raft CHRNA3, CHRNA7, INSR, PTGS2, SRC 2.37239
[CC] GO:0098794 None ADORA1, APP, CHRNA7, GRIA2, GRIA4, GRM3 2.28427
[CC] GO:0043005 None ADORA1, APP, BACE1, CA2, CHRNA3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC 2.12385
[CC] GO:0097458 None ADORA1, APP, BACE1, CA2, CACNA1C, CHRNA3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HIF1A, INSR, PTGS1, PTGS2, SRC 2.05642
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.2995
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, F3, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, SRC, TEK, TERT, TOP2A, TYR, XDH 13.9987
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, SMAD3, TYR, XDH 13.2603
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 12.1424
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.993
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.87525
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRNA3, CHRNA7, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, PTAFR, TEK 8.63802
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, SMAD3 8.21526
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, TEK 8.00414
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.73893
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRNA3, CHRNA7, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, PTAFR, TEK 7.5663
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.32752
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, CHRNA3, CHRNA7, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, PTAFR, TEK 7.25782
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, CHRNA3, CHRNA7, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, PTAFR, SMAD3, TEK 7.2456
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, TEK 7.19526
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, HMGCR, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.81337
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 6.36816
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRNA3, CHRNA7, EDNRA, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, TEK 6.27126
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRNA3, CHRNA7, EDNRA, EGFR, ERBB2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, TEK 6.27126
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK, TOP2A 6.02373
[MF] GO:0042562 hormone binding ACHE, CHRNA3, CHRNA7, EGFR, HSD17B1, IGF1R, INSR, NQO2 5.71384
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, TERT, TOP2A, TYR, XDH 5.4654
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, HMGCR, HSD17B1, NQO2, PTGES, PTGS1, PTGS2, SRC, XDH 5.46468
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, INSR, KDR 4.99591
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, ALDH2, AOX1, XDH 4.94034
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CHRNA7, CSNK2A1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MIF, MMP9, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH 4.85127
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.64199
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.64199
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SLC1A1, SRC, TEK, TOP2A, XDH 4.57681
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, TERT, TOP2A, TYR, XDH 4.4172
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.33675
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HMGCR, HSD17B1, HSD17B2, XDH 4.31765
[MF] GO:0019899 enzyme binding ADRB1, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRB, F3, GRM5, HIF1A, HMGCR, HSPA1A, MET, MIF, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 4.05396
[MF] GO:0043168 anion binding ABCB1, AOX1, APP, AURKB, AXL, CSNK2A1, DAO, DYRK1A, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTAFR, PTGES, SLC1A1, SRC, TEK, TOP2A, XDH 3.93624
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.92759
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.91639
[MF] GO:0000166 nucleotide binding ABCB1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 3.90758
[MF] GO:1901265 nucleoside phosphate binding ABCB1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 3.9052
[MF] GO:0030594 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM5 3.89984
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.86946
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET, PPARA, PTPN1, SMAD3 3.77929
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT 3.55958
[MF] GO:0098960 None CHRNA3, CHRNA7, GRM1, GRM5 3.54704
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.48932
[MF] GO:0005231 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.46088
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRB1, AOX1, AXL, BCL2, CHRNA7, DAO, EGFR, ERBB2, FLT3, HIF1A, HMGCR, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH 3.42368
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.42335
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.42335
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.4092
[MF] GO:0022824 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.39244
[MF] GO:0022835 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.39244
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.31243
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.22985
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.21079
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.17152
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.11553
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.10116
[MF] GO:0001540 amyloid-beta binding ACHE, BACE1, CHRNA7, GRIA2, INSR 3.07425
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.97943
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.90509
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.85978
[MF] GO:0045550 None AKR1B10, AKR1C3 2.85978
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.85978
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.83887
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET, PTPN1 2.78676
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HMGCR, HSD17B1, HSD17B2 2.7721
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.72104
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, INSR, KDR, SMAD3 2.72104
[MF] GO:0005230 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 2.69624
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.62249
[MF] GO:0019838 growth factor binding EGFR, ERBB2, IGF1R, INSR, KDR, TEK 2.58829
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, AKR1C3, ALDH2, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EDNRA, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 2.56333
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.51212
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.48313
[MF] GO:0047718 None AKR1B10, AKR1C3 2.48313
[MF] GO:0032450 None GAA, MGAM 2.48313
[MF] GO:0099583 None GRM1, GRM5 2.48313
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 2.47275
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.4617
[MF] GO:0042166 None ACHE, CHRNA3, CHRNA7 2.4531
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.32525
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.32525
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.26257
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, HIF1A, PTAFR, PTPN1, SMAD3, SRC, TOP2A 2.2621
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.22839
[MF] GO:0004971 None GRIA2, GRIA4 2.22839
[MF] GO:0051425 None APP, INSR 2.22839
[MF] GO:0004558 None GAA, MGAM 2.22839
[MF] GO:0033218 amide binding ACHE, BACE1, CHRNA7, GRIA2, IGF1R, INSR, NQO2, PTGES 2.19485
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, GRM5, HIF1A, PTAFR, PTPN1, SMAD3, SRC, TOP2A 2.1711
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HIF1A, HSPA1A, KDR 2.12626
[MF] GO:0042803 protein homodimerization activity ACHE, AOX1, BCL2, CHRNA7, FLT3, HMGCR, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH 2.12385
[MF] GO:0008134 transcription factor binding APEX1, BCL2, ESR1, ESRRB, FLT3, HIF1A, PIM1, PPARA, SMAD3, SRC, TERT 2.10713
[MF] GO:0046982 protein heterodimerization activity ADORA1, ADRB1, AXL, BCL2, EGFR, ERBB2, HIF1A, SMAD3, TOP2A, TYR 2.08246
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04863
[MF] GO:0043559 insulin binding IGF1R, INSR 2.04863
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.02343
[MF] GO:0005102 receptor binding ADORA1, ADRB1, APP, DAO, EGFR, ERBB2, ESR1, ESR2, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MIF, PTPN1, SMAD3, SRC 2.00063


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.6927
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 11.329
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, CHRNA3, GPR35, CHRNA7, GRIK5, PTAFR, ADRB1, GRM1, GRM3, GRM5, EDNRA, ADORA3, GRM8, ADORA1, GRIA4 9.3509
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 8.5355
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, ERBB2, KDR, PIK3CB, MMP9, MET, ESR1, HIF1A, EGFR, IGF1R 7.991
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, ERBB2, MET, EGFR, IGF1R 8.3928
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, HIF1A, EGFR, IGF1R, EDNRA, PIK3CA, ERBB2, BCL2, MET 7.5885
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, ADRB1, PIK3CB, PTGS2, PTGS1 7.991
Metabolic pathways_Homo sapiens_hsa01100 MGAM, DNMT1, GAA, GBA, AKR1C3, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, FUT7, DAO, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 7.0082
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, ERBB2, BCL2, TEK, PIK3CB, HIF1A, EGFR, IGF1R 7.343
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 7.0082
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, PIK3CA, ERBB2, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 6.3957
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, ERBB2, PIK3CB, MET, HIF1A, EGFR 6.2556
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 6.6341
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, EDNRA, CHRNA7, PTAFR, ERBB2, ADRB1, CACNA1C, GRM1, EGFR 5.4789
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 5.1542
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, EDNRA, PIK3CA, ADORA1, ADRB1, CACNA1C, PIK3CB, PPARA, GRIA4 5.1628
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, GRM8, PIK3CB, GRM1, EGFR 5.1752
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, ERBB2, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 5.1542
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.1952
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.0174
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CHRNA3, PIK3CA, CHRNA7, BCL2, CACNA1C, PIK3CB 4.937
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 EDNRA, PIK3CA, ADORA3, INSR, ADORA1, ADRB1, CACNA1C, PIK3CB 4.8386
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 4.4672
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, ERBB2, BCL2, PIK3CB, EGFR, IGF1R 4.4057
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, PTGS2, GRM1, GRIA4 4.1042
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 3.9825
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 3.5875
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.0515
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, ADRB1, MET, EGFR, IGF1R, HSPA1A 3.6251
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1 4.8867
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 3.9931
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, AKR1C3, PTGS2, PTGES, PTGS1 4.0425
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, ERBB2, PIK3CB, EGFR 3.9547
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 3.8128
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.7956
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.3827
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2, EGFR 3.2247
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, ERBB2, PIK3CB, EGFR 3.4464
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, ADRB1, GRM1, EGFR 3.4336
Chemical carcinogenesis_Homo sapiens_hsa05204 CHRNA7, CYP1A2, CYP1A1, CYP1B1, PTGS2 3.5583
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.0647
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, CACNA1C, PTGS2, PTGS1 3.0218
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1, HIF1A 2.9626
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 2.9626
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 2.9547
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, HMGCR, IGF1R 2.9014
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.657
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, ADRB1, CACNA1C, PIK3CB 2.5897
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, ERBB2, PIK3CB, EGFR 3.1342
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, ERBB2, PIK3CB, EGFR 3.2404
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.1138
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.4954
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.0083
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 2.9626
Renin secretion_Homo sapiens_hsa04924 EDNRA, ADORA1, ADRB1, CACNA1C 2.9638
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, CACNA1C, PIK3CB 3.367
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.094
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.4125
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 2.9547
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.5089
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.2423
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET, HIF1A 2.9547
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.706
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.0969
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.4692
Galactose metabolism_Homo sapiens_hsa00052 MGAM, AKR1B10, GAA, AKR1B1 4.0425
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, HIF1A, EGFR 2.3721
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.581
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.1376
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.209
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2179
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 1.9957
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2291
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 1.9767
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, CACNA1C, EGFR, CDC25B, HSPA1A 1.7375
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2662
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 1.9481
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.8468
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9014
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3036
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.3823
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6085
Axon guidance_Homo sapiens_hsa04360 MET 0.3179
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3256
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1347
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB 1.1665
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.3823
Lysosome_Homo sapiens_hsa04142 FUCA1, GAA, GBA 1.3591
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.2476
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.5979
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3875
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3885
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.0382
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5761
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 0.9108
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4012
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP, CACNA1C 1.0774
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 0.9801
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, CACNA1C, GRIA4 1.3236
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.706
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4135
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.5334
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6946
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4165
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.5981
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.4165
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.7206
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.7272
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4269
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.762
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.415
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.6254
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4165
Vascular smooth muscle contraction_Homo sapiens_hsa04270 EDNRA, CACNA1C 0.7696
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4252
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.8492
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.6459
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4347
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.8598
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4286
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4431
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4411
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.8854
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4451
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 0.9259
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4569
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.8969
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4569
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4693
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9469
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4569
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 0.9905
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 0.9469
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 1.9126
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.957
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 0.9905
Shigellosis_Homo sapiens_hsa05131 SRC 0.4913
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.4828
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.4913
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.0774
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, CACNA1C, GRIA4 1.9851
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB, HIF1A 2.094
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.094
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 1.9126
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.1184
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR 1.9348
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9767
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.0116
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.0923
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.0976
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5417
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.1108
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5458
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.5643
Malaria_Homo sapiens_hsa05144 MET 0.5817
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.595
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.5979
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA 0.595
Starch and sucrose metabolism_Homo sapiens_hsa00500 MGAM, GAA 1.2565
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6068
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6008
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6068
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 MGAM, PIK3CA, PIK3CB 2.4125
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3236
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.5564
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO, ALDH2 1.3314
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.3437
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.3563
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, CHRNA7, GRIA4 2.5306
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.6383
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6882
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.6609
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7222
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.762
Base excision repair_Homo sapiens_hsa03410 APEX1 0.706
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7399
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.6388
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.7222
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2, GLO1 1.4884
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7399
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7657
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.647
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.762
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.762
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.7921
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8245
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9126
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9112
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9751
Other glycan degradation_Homo sapiens_hsa00511 FUCA1, GBA 2.0736
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2822
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0218


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)