TCM Prescription: Gu Jin Pills



Prescription Description
Prescription IDTCMF3458
Pinyin NameGu Jin Wan
Chinese Name骨筋丸
English NameGu Jin Pills
Function Description痹病, 跌打损伤, 项痹
IndicationsArthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH2348 Sanguis draconis 血竭 TCMH2348
TCMH1405 Strychnos nux-vomica 马钱子 TCMH1405 PPBI045-16
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 13.0398
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 13.0398
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2A, HTR2B, HTR7, INSR, KDR, MAOA, MET, PPARA, SLC1A1, SMAD3, SRC, TEK, XDH 12.7756
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, TEK, XDH 12.4612
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MMP2, MMP9, NUAK1, PGR, PIM1, PTGES, RELA, SMAD3, SRC, TEK, XDH 11.8129
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, GRIK5, GRM5, HSD17B2, HTR5A, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, PTGES, RELA, SRC, TEK, TYR 11.4076
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 11.4076
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PTPN1, RELA, SRC, TEK, XDH 11.3541
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 11.2641
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 11.2305
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, HTR5A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TYR 11.0007
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.6388
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PTGES, RELA, SMAD3, SRC, TEK, TYR 10.4475
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 9.75357
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 9.67277
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, SIGMAR1, SMAD3, SRC, TEK 9.66403
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 9.57353
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 9.57353
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FLT3, HTR5A, NR3C1, PTGES, RELA, SRC, TEK, TYR 9.27983
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, FABP3, FLT3, GRM5, HTR5A, IGF1R, INSR, MMP2, NR3C1, PPARA, RELA, SMAD3, SRC, TEK 9.27983
[BP] GO:0007193 None ADORA1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 9.0012
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR6, HTR7 8.94026
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 8.66931
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, HTR2A 8.52031
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 8.52031
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 8.52031
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 8.31391
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 8.31391
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MET, PPARA, PTGES 8.28619
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, APP, AR, DRD2, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, PTPN1, SRC, TEK, XDH 8.27793
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, INSR, MET, SMAD3 8.06709
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.06709
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP4, GRM1, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TYR 8.06709
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, INSR, MET, SMAD3, SRC 7.98458
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, GRIK5, GRM5, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 7.82379
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, APP, AR, DRD2, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, PTPN1, SRC, TEK, XDH 7.74594
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, PPARA, RELA, SMAD3, SRC, TEK, TYR 7.74594
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RELA, SLC1A1, SMAD3, SRC, TEK, XDH 7.74049
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, HSD17B3 7.53618
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, HTR5A, INSR, NR3C1, PPARA, RELA, SRC, TEK 7.51544
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 7.51544
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TEK, XDH 7.31527
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 7.29406
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 7.27913
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TEK, XDH 7.19151
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGES, RELA, SRC 7.14363
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, TEK, XDH 7.12506
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, RELA, TEK 7.07724
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GRIK5, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PTPN1, RELA, SIGMAR1, SMAD3, SRC, TEK, XDH 7.04136
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GRIK5, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SIGMAR1, SMAD3, SRC, TEK, XDH 7.03714
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TEK, XDH 7.02096
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PTPN1, RELA, SRC, TEK, XDH 6.99429
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP2, MMP9, NR3C1, NUAK1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TYR 6.96665
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, HTR5A, NR3C1, PTGES, RELA, SRC, TYR 6.96288
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, GRM1, HSPA1A, HTR2A, HTR2B, MMP2, PPARA, RELA, SMAD3, SRC, TEK, TYR 6.93487
[BP] GO:0050801 ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, FABP3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 6.65022
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.65022
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.65022
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.60833
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK 6.60403
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 6.53417
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.52771
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GRIK5, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MMP9, PIM1, PTPN1, RELA, SIGMAR1, SMAD3, SRC, TEK, XDH 6.51605
[BP] GO:0007154 None ADORA1, ADRA1A, AR, AXL, BCL2, CACNA1C, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, PGR, SLC1A1, TEK 6.51002
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK 6.51002
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, HTR1A, INSR, MAOA, SLC1A1, SMAD3 6.43641
[BP] GO:0023052 None ADORA1, ADRA1A, AR, CACNA1C, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, PGR, SLC1A1, TEK 6.4155
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MAP3K7, MET, MMP2, MMP9, PTPN1, RELA, SMAD3, SRC, TEK 6.38541
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 6.36372
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.35093
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.33032
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, MAOA, TYR 6.32157
[BP] GO:0007267 None ADORA1, ADRA1A, AR, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, PGR, SLC1A1, TEK 6.29493
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 6.2384
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSD11B1, HSD17B2, HSD17B3, HTR5A, INSR, KDR, MAP2K1, MMP9, PGR, PIM1, PPARA, RELA, SIGMAR1, SMAD3, SRC, TEK, TYR 6.22946
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 6.14985
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.14985
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 6.14985
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, DUSP3, EGFR, HTR2A, HTR2B, KDR, MAP2K1, PTPN1, SRC, TEK 6.1434
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, KDR, NR3C1, RELA, SRC 6.11335
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC 6.11304
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, HSD17B3, HSPA1A, HTR2B, PIM1, PPARA, PTGES, TYR, XDH 6.09012
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 6.07295
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HSD17B3, HTR1A, MAOA, TYR 6.06715
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 6.04754
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RELA, SMAD3, SRC 6.0367
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, EGFR, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 6.02882
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, INSR, KDR, MAP2K1, MET, MMP2, MMP9, PGR, PIM1, PPARA, RELA, SIGMAR1, SMAD3, SRC, TEK, TYR 6.00514
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC, TEK 5.98061
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.97058
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, RELA, SMAD3, SRC, TEK 5.93817
[BP] GO:0007268 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 5.8964
[BP] GO:0098916 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 5.8964
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A 5.87957
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PTPN1, RELA, SRC, TEK 5.8319
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.81562
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, F3, HSPA1A, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MET, MMP9, PIM1, RELA, SLC1A1, SMAD3, SRC, TEK 5.80506
[BP] GO:0099536 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 5.80506
[BP] GO:0099537 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 5.80506
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.77303
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.74141
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC 5.73157
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.71384
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 5.70049
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TEK, XDH 5.69664
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP2, MMP9, NR3C1, NUAK1, PTPN1, RELA, SMAD3, SRC 5.69664
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.69664
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.69664
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.69664
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.69226
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DRD1, EGFR, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, NR3C1, RELA, SMAD3, SRC 5.66109
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.64539
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, NUAK1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.63367
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.62463
[BP] GO:0055080 cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.57818
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC, TEK 5.57541
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.57541
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, EGFR, HTR2A, HTR2B, KDR, MAP2K1, SRC, TEK 5.55719
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.54496
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, PTPN1, SRC, TEK 5.54182
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.51623
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 5.51623
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, GRIK5, GRM5, HSPA1A, HTR1A, HTR2A, HTR2B, INSR, MAP2K1, MMP9, PPARA, PTPN1, SMAD3, SRC 5.50869
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.50591
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.46536
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, KDR, SRC 5.46536
[BP] GO:0042391 None ADORA1, ADRA1A, APP, BCL2, CACNA1C, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 5.44358
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, PTPN1, SRC 5.42849
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 5.42556
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.38637
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.386
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.38114
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, EGFR, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.34
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.34
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 5.3249
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, APP, CA2, DRD1, DRD2, DRD3, GPR35, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, INSR, SIGMAR1, SRC 5.28894
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.28894
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, RELA, SRC, TEK, TYR 5.27904
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.26206
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.23782
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, PTPN1, SMAD3, SRC, TEK, XDH 5.22192
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, PTPN1, SRC, TEK 5.13971
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, PTPN1, SRC 5.09258
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 5.08252
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, EGFR 5.07076
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.0652
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.06295
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, XDH 5.0301
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.01124
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.00167
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.00167
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A, MAOA 4.96969
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, CACNA1C, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2B, HTR5A, KDR 4.93506
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, RELA, SRC, TEK, TYR 4.84962
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A, MAOA 4.84162
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, MAP2K1, RELA, SMAD3, TYR 4.82724
[BP] GO:0055065 metal ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, EGFR, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.81664
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.81082
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 4.7919
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.7919
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.7919
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.72062
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.72062
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, AR, BCL2, DRD1, DRD2, DRD3, DUSP3, EGFR, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP9, PTPN1, RELA, SMAD3, SRC, XDH 4.71524
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, AR, BCL2, DRD1, DRD2, DRD3, DUSP3, EGFR, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP9, PTPN1, RELA, SMAD3, SRC, XDH 4.6948
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TYR, XDH 4.64903
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, DRD1, EGFR, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, RELA, SRC 4.63917
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TYR, XDH 4.62475
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PTGES 4.60994
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, RELA, SRC 4.60994
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.59544
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.52456
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.50247
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 4.48252
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.4659
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.4659
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, APP, AR, AXL, BCL2, CA2, CACNA1C, CYP1B1, DRD2, DRD3, EGFR, F3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, PIM1, RELA, SLC1A1, SMAD3, SRC, TEK, XDH 4.45311
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 4.45031
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DRD2, DUSP3, EGFR, F3, FABP4, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MMP2, NUAK1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 4.45031
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.45031
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MAP3K7, PTPN1, SRC 4.43878
[BP] GO:0019725 cellular homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.42336
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.40203
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.39969
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 4.38969
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.35043
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 4.34653
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, MAP2K1, MAP3K7, PTPN1, SRC 4.34131
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, DUSP3, HSPA1A, IGF1R, MET, MMP9, PTPN1, RELA, SRC, XDH 4.32248
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GPR35, GRM5, HTR1A, HTR2A, MMP9 4.31297
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PTPN1, RELA, SMAD3, SRC, TEK, XDH 4.29514
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.29514
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2, HSD17B3 4.29514
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 4.29514
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, HTR7, PGR, PPARA, SRC 4.27679
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.26639
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, EGFR, FLT3, NR3C1, RELA, SRC 4.26148
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, APP, BCL2, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR7, INSR, SRC, TEK, TYR 4.24434
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, NR3C1, PIM1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, XDH 4.22339
[BP] GO:0007610 None APP, BCL2, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR1A, HTR2A, HTR2B, INSR, PPARA 4.13322
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.13322
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 4.13078
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGES 4.13058
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TYR, XDH 4.07494
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, PPARA, SLC1A1 4.05479
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, RELA, SRC 4.00288
[BP] GO:0030522 intracellular receptor signaling pathway AR, MAP3K7, NR3C1, PGR, PIM1, PPARA, RELA, SRC 3.98582
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, FLT3, HTR1A, MAP2K1, MET, PIM1, SRC, TEK, TYR 3.97235
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, FUT7, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, TYR, XDH 3.95103
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC, TEK 3.94361
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.94121
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.94121
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, RELA, SRC 3.94025
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 3.92361
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGES 3.85803
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, SRC, TEK 3.85803
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.84623
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP3K7, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.83538
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, AR, BCL2, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 3.79363
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, F3, FABP4, KDR, MAP2K1, MET, PPARA, RELA, SMAD3, TEK 3.78642
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, DRD1, EGFR, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, RELA, SMAD3, SRC 3.77613
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.76429
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.73031
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.70727
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, GRM5, HTR2A, HTR2B 3.69012
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 3.68926
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, HSD17B2, HSD17B3, INSR, MAP2K1, PGR, SRC 3.6796
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, AR, BCL2, CYP1B1, DRD2, FABP3, HSPA1A, MAP2K1, PTGES, SMAD3, XDH 3.64762
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.61147
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 3.60864
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, GPR35, HTR2A, MMP9 3.58955
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, HSD17B2, HSD17B3, INSR, MAP2K1, SRC 3.57645
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, CACNA1C, DRD2, DRD3, EGFR, GPR35, GRM1, HTR2A, SLC1A1, SMAD3 3.57645
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, NR3C1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, XDH 3.57645
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A, INSR 3.55476
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, RELA, SRC, TEK 3.55267
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.55267
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.55267
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, DRD2, DRD3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.53469
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, EGFR, FLT3, NR3C1, SRC 3.53469
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.4552
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.4552
[BP] GO:0008217 None ADORA1, ADRA1A, AR, DRD2, DRD3, PPARA, SMAD3 3.45134
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, NR3C1, RELA, SRC 3.44341
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 3.42789
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.42181
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC, TEK 3.41876
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, RELA, TYR 3.41189
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 3.39727
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 3.38735
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 3.38526
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.36315
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.36315
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.36315
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.36315
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, SIGMAR1, SMAD3, SRC, TEK, XDH 3.36274
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.35405
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 3.3536
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOA 3.31107
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.31107
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 3.29101
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3 3.29036
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, HSD17B2, HSD17B3, INSR, MAP2K1, MMP2, MMP9, PGR, SRC 3.28589
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.23715
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, XDH 3.22196
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 3.22151
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 3.21781
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, HTR2A, PTPN1, SRC 3.20521
[BP] GO:0035265 organ growth ADRA1A, AR, BCL2, CYP19A1 3.20521
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.18199
[BP] GO:0060402 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 3.18199
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.17851
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.17851
[BP] GO:1900542 None DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A, INSR, PPARA 3.17247
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MAP3K7, MMP2, PPARA, PTPN1, RELA, SMAD3, SRC, TEK 3.1628
[BP] GO:0007611 None APP, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A, INSR 3.1628
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.15944
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, RELA, SRC 3.15134
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, EGFR, GRM1, INSR, MAP2K1, MAP3K7, PTPN1, SRC 3.12944
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.11041
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.10702
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 3.10594
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TYR, XDH 3.10432
[BP] GO:0006140 None DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A, INSR, PPARA 3.09701
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP3K7, MET, PPARA, PTPN1, RELA, SMAD3 3.08827
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.06433
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 3.06433
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SRC 3.05476
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, RELA, SMAD3, SRC 3.05136
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.03352
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, GPR35, GRM1, HTR2A, HTR2B 3.0168
[BP] GO:1900543 None DRD2, DRD3, GRM3, GRM8, PPARA 2.99608
[BP] GO:0050678 None AR, EGFR, F3, HTR2B, KDR, PGR, SMAD3, TEK, XDH 2.97986
[BP] GO:0045980 None DRD2, DRD3, GRM3, GRM8, PPARA 2.96989
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 2.92953
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, AXL, BCL2, CA2, CA9, CACNA1C, CYP1B1, DRD2, EGFR, HTR2B, INSR, MET, MMP2, RELA, SMAD3, SRC, TEK 2.9261
[BP] GO:0071383 None AR, EGFR, FLT3, NR3C1, SRC 2.9199
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 2.90866
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 2.89078
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, RELA, SRC 2.89078
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.88823
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 2.87031
[BP] GO:0060401 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 2.87031
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC 2.8661
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.86293
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.86293
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.86293
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HTR2B, MET, PPARA, RELA, SMAD3 2.86248
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HTR2B, INSR, SMAD3, SRC 2.86178
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.85166
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, SRC 2.82798
[BP] GO:0034762 None APP, BCL2, CA2, CACNA1C, DRD1, DRD2, DRD3, GPR35, GRM5, MMP9 2.81147
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, EGFR, FABP4, GRM3, GRM8, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, NR3C1, PGR, PPARA, PTPN1, RELA, SMAD3, SRC, XDH 2.80592
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.76957
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.76957
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, HTR1A, MAP2K1, MAP3K7, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK 2.76826
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.75372
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, RELA, TYR 2.72901
[BP] GO:0007612 None APP, DRD1, DRD2, DRD3, GRM5, INSR 2.72733
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA, SMAD3, TEK 2.69524
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, RELA, SMAD3, SRC 2.69524
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.6931
[BP] GO:1901224 None APP, EGFR, MAP3K7, RELA 2.6931
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.68542
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.68542
[BP] GO:0060341 regulation of cellular localization APP, AR, BCL2, CACNA1C, CSNK2A1, DRD1, DRD2, DRD3, EGFR, GRIK5, MAP2K1, PTPN1, SMAD3, SRC 2.68458
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.68365
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.67088
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 2.66897
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MET, NR3C1, PGR, PPARA, RELA, SMAD3, SRC 2.66897
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, F3, HTR2A, INSR, KDR, MAP2K1, PIM1, RELA, SMAD3, SRC, TEK 2.65238
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, IGF1R, INSR, RELA, SRC 2.6488
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, CACNA1C, DRD2, EGFR, HTR2A, SLC1A1 2.64469
[BP] GO:0030818 None DRD2, DRD3, GRM3, GRM8 2.62704
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MMP9, PTPN1, RELA, SRC 2.61558
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.61336
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.61336
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR 2.61336
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, SRC 2.61336
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP2, MMP9, SRC, XDH 2.59551
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MAP2K1, MET, MMP1, MMP9, SRC, TEK 2.59551
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.58794
[BP] GO:0009410 None DRD1, DRD2, DRD3, EGFR, NR3C1, RELA 2.58541
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, SMAD3, SRC, TEK, TYR, XDH 2.58541
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, HTR1A 2.56867
[BP] GO:0030803 None DRD2, DRD3, GRM3, GRM8 2.5657
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HTR1A, HTR2A, HTR2B, SRC 2.5657
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.54966
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGES 2.53952
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MAP2K1, MMP1, MMP9, SRC, TEK 2.5343
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3, SRC 2.5343
[BP] GO:0099566 None GRM1, GRM5 2.5343
[BP] GO:0033590 None EGFR, RELA 2.5343
[BP] GO:0060748 None AR, PGR 2.5343
[BP] GO:0060160 None DRD2, DRD3 2.5343
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.5343
[BP] GO:0002520 None CACNA1C, SMAD3 2.5343
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.50731
[BP] GO:0030815 None DRD2, DRD3, GRM3, GRM8 2.50731
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DRD1, DRD2, DRD3, EGFR, HSPA1A, HTR2A, IGF1R, INSR, MAP2K1, MET, NR3C1, PGR, PPARA, PTPN1, RELA, SMAD3, SRC 2.50682
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.481
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 2.4779
[BP] GO:1900372 None DRD2, DRD3, GRM3, GRM8 2.4779
[BP] GO:0030809 None DRD2, DRD3, GRM3, GRM8 2.4779
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.4779
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, AR, BCL2, DRD2, DRD3, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP9, PTPN1, RELA, SMAD3, SRC, XDH 2.47112
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, NR3C1, SRC 2.46974
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR 2.46687
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2 2.46276
[BP] GO:0030800 None DRD2, DRD3, GRM3, GRM8 2.44979
[BP] GO:0022898 None APP, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9 2.44568
[BP] GO:0032989 cellular component morphogenesis APP, AR, AXL, BCL2, DRD2, EGFR, MET, SRC, TEK 2.42474
[BP] GO:0030817 None DRD1, DRD2, DRD3, GRM3, GRM8 2.42474
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.42474
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.42474
[BP] GO:0007568 aging ADRA1A, AURKB, BCL2, CYP1A1, HTR2A, MAP2K1, RELA 2.41663
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.38859
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.38859
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, SRC, TEK 2.37878
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.3629
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.3629
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.35324
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.34983
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, IGF1R, INSR, MAP2K1, MET, NR3C1, PGR, PPARA, RELA, SMAD3, SRC 2.33996
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.33996
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, HSPA1A, RELA, SRC 2.33996
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.33996
[BP] GO:0000186 activation of MAPKK activity ADORA1, EGFR, GRM1, MAP3K7 2.33996
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.33996
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, MAP2K1, TEK, TYR 2.31757
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, SRC 2.31757
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HTR1A, HTR2A, HTR2B, SRC 2.31439
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.31221
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.31048
[BP] GO:0032409 None APP, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9 2.31048
[BP] GO:0046328 regulation of JNK cascade APP, DUSP3, EGFR, IGF1R, MAP3K7, PTPN1 2.29536
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.29536
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, RELA, TYR 2.28538
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28494
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, PPARA, SMAD3, TEK 2.27344
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.26275
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, HTR2A, PTPN1, SRC 2.24752
[BP] GO:0050679 None AR, EGFR, F3, HTR2B, KDR, TEK 2.22195
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.20763
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.20397
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20397
[BP] GO:0007626 None APP, DRD1, DRD2, DRD3, GRM1, GRM5 2.17388
[BP] GO:0051282 None CACNA1C, DRD1, DRD2, HTR2A, HTR2B 2.17388
[BP] GO:0019722 calcium-mediated signaling CACNA1C, EGFR, GRM5, HTR2B, KDR 2.17388
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, NUAK1, PTPN1, XDH 2.17388
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.15862
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, MAOA 2.15862
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 2.15862
[BP] GO:0051894 None KDR, SMAD3, TEK 2.15574
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.15574
[BP] GO:0040008 regulation of growth APP, AR, BCL2, CSNK2A1, DRD2, DRD3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.15574
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.14419
[BP] GO:1901222 None APP, EGFR, MAP3K7, RELA 2.13635
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.13635
[BP] GO:0050877 None ADORA1, APP, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HTR2A, INSR, TYR 2.1332
[BP] GO:0030814 None DRD1, DRD2, DRD3, GRM3, GRM8 2.12991
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CYP19A1, DRD2, EGFR, HTR1A, HTR2A 2.11556
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, PTGES 2.10918
[BP] GO:0050927 None F3, KDR, SMAD3 2.10918
[BP] GO:0048169 None APP, DRD2, GRM5 2.10918
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.10875
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK, XDH 2.09914
[BP] GO:0021853 None DRD1, DRD2 2.09914
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.09914
[BP] GO:0010641 None F3, SRC 2.09914
[BP] GO:0090325 None DRD2, DRD3 2.09914
[BP] GO:0007598 None F10, F3 2.09914
[BP] GO:1904936 None DRD1, DRD2 2.09914
[BP] GO:0042321 None ADORA1, DRD2 2.09914
[BP] GO:0010513 None HTR2A, HTR2B 2.09914
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.09914
[BP] GO:0010959 None ADORA1, BCL2, CACNA1C, DRD1, DRD2, DRD3, GPR35, HTR2A 2.09914
[BP] GO:0030802 None DRD1, DRD2, DRD3, GRM3, GRM8 2.09432
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.07895
[BP] GO:0050926 None F3, KDR, SMAD3 2.07425
[BP] GO:1903393 None KDR, SMAD3, TEK 2.07425
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.07425
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.06594
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, F10, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC, TEK 2.04668
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3 2.0308
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.0308
[BP] GO:0090068 positive regulation of cell cycle process APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR 2.03015
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.03
[BP] GO:0045913 None HTR2A, INSR, PPARA, SRC 2.00986
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.00986
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.00667
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGES, RELA, SRC 2.00606
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CA4, DRD1, DRD2, DRD3, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, TEK 10.0865
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, NR3C2, PGR, PIM1, PTGES, PTPN1, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TYR 9.27983
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, APP, AXL, CA2, CA4, CA9, CACNA1C, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, SRC, TEK 8.85882
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, DRD1, DRD2, DRD3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, TEK 8.34432
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK 8.17845
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MET, NR3C2, PTGES, PTPN1, SIGMAR1, SLC1A1, SRC, TEK, TYR 7.55208
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, DRD1, DRD2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, INSR, MET, SIGMAR1, SLC1A1, SRC, TEK 7.08809
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, F10, FLT3, GRIA2, HSD11B1, HSD17B2, HSD17B3, NR3C2, PTGES, PTPN1, SIGMAR1 4.68074
[CC] GO:0014069 None ADORA1, CACNA1C, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 4.57425
[CC] GO:0099572 None ADORA1, CACNA1C, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 4.57425
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, GRIA2, HSD11B1, HSD17B2, HSD17B3, NR3C2, PTGES, SIGMAR1 4.26196
[CC] GO:0043235 receptor complex APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, NR3C2, SMAD3 3.82711
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1, SRC 3.69601
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CACNA1C, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MET, PTGES, SIGMAR1, SLC1A1, TEK, TYR 3.69012
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, HSD17B3, HSPA1A, HTR5A, KDR, MAP2K1, PTPN1, SIGMAR1, XDH 3.5131
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.4552
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.23976
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC, TEK 3.17649
[CC] GO:0043005 None ADORA1, APP, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, SRC 3.13128
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2A, HTR5A, INSR, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGES, PTPN1, RELA, SIGMAR1, SMAD3, SRC, TYR, XDH 3.12679
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.03352
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.99608
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC, TEK 2.97101
[CC] GO:0016021 None ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, CA12, CA14, CA9, CACNA1C, DRD1, DRD2, DRD3, EGFR, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MET, PTGES, SIGMAR1, SLC1A1, TEK, TYR 2.68542
[CC] GO:0097458 None ADORA1, APP, CA2, CACNA1C, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, INSR, SIGMAR1, SRC 2.63859
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1 2.62637
[CC] GO:0045121 membrane raft ADRA1A, APP, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.57532
[CC] GO:0098857 membrane microdomain ADRA1A, APP, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.55856
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.50731
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, SIGMAR1, SRC 2.47462
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, SIGMAR1, SRC 2.47462
[CC] GO:0031233 None CA4, F10, F3 2.3629
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.09914
[CC] GO:0098589 membrane region ADRA1A, APP, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.09914
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AR, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, SIGMAR1, TEK 13.1613
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AR, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NR3C1, NR3C2, PGR, PPARA, SIGMAR1, SMAD3, TEK 13.1523
[MF] GO:0030594 None DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 12.7086
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AR, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, SIGMAR1, TEK 12.4127
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AR, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, SIGMAR1, TEK 12.0391
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 10.9544
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 10.9544
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, SMAD3, TYR, XDH 10.934
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, SLC1A1, SMAD3, SRC, TEK, TYR, XDH 10.9108
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.77818
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.06853
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.98458
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, EGFR, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PPARA, SIGMAR1, SRC, TEK 7.83148
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.81121
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.2489
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.00219
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.73672
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.69769
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.69769
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.65022
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.65022
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, F10, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MAP3K7, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, SLC1A1, SMAD3, TYR, XDH 6.50857
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.2853
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NR3C1, SHBG 6.07295
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.03413
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F10, F3, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTGES, PTPN1, SRC, TEK, TYR, XDH 5.9372
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 5.8319
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 5.75981
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.60171
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 5.50869
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 5.2714
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.2538
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.22195
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, GPR35, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 5.20053
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 4.90124
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.87202
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 4.68074
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 4.67175
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.40839
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 4.34653
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, SMAD3 4.27217
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 3.7812
[MF] GO:0005496 steroid binding AR, HSD17B1, NR3C1, NR3C2, PGR, SHBG 3.71339
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, HSD17B3, XDH 3.68632
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 3.36805
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.36349
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, PPARA 3.33459
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.31107
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC 3.29036
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.25672
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, PTGES, SRC, XDH 3.16492
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC 3.13128
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.015
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, MAP2K1, MAP3K7, SMAD3 2.96049
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.95717
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 2.94329
[MF] GO:0008389 None CYP2A13, CYP2A6 2.93271
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.86293
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, F10, MAP3K7, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, SLC1A1, SMAD3, TYR, XDH 2.77178
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 2.64695
[MF] GO:0008289 lipid binding AR, AXL, F10, F3, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, SHBG 2.59551
[MF] GO:0099583 None GRM1, GRM5 2.5343
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.42474
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.42474
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.3629
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.3528
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.30703
[MF] GO:0097159 organic cyclic compound binding ADORA1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RELA, SHBG, SMAD3, SRC, TEK, XDH 2.29465
[MF] GO:0004971 None GRIA2, GRIA4 2.28494
[MF] GO:0005497 None AR, SHBG 2.28494
[MF] GO:0051425 None APP, INSR 2.28494
[MF] GO:0043168 anion binding APP, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTGES, RELA, SLC1A1, SRC, TEK, XDH 2.22233
[MF] GO:0043559 insulin binding IGF1R, INSR 2.09914
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGES, PTPN1, RELA, SHBG, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TYR, XDH 2.08826
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, F3, GRM5, HSPA1A, MET, NR3C1, PGR, PPARA, PTPN1, RELA, SMAD3, SRC, TEK 2.03


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GPR35, GRIK5, HTR2B, HTR1A, HTR2A, NR3C1, HTR5A, ADRA1A, GRM1, GRM3, HTR6, GRM5, HTR7, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, GRIA4 17.5832
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, MAP2K1, HTR7, MAOA, CYP2D6, ALOX5, HTR2B, HTR1A, CACNA1C, HTR2A, HTR5A 11.2357
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.8159
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MAP3K7, MET, EGFR, IGF1R 8.8438
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, GRM5, HTR7, HTR2B, CACNA1C, HTR2A, DRD1, HTR5A, ADRA1A, GRM1, EGFR 8.0972
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.5882
Gap junction_Homo sapiens_hsa04540 GRM5, MAP2K1, SRC, HTR2B, HTR2A, DRD1, DRD2, GRM1, EGFR 8.3948
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, HTR6, MAP2K1, ADORA1, HTR1A, CACNA1C, DRD1, DRD2, PPARA, RELA, GRIA4 7.6847
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 8.3948
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 7.5346
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, RELA, IGF1R 5.7256
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.3524
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9, EGFR 6.4338
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, GRM1, EGFR, HSPA1A 5.5281
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.4414
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, INSR, KDR, TEK, MET, EGFR, RELA, IGF1R 5.1997
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA, DRD1, DRD2, RELA 6.0256
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, INSR, BCL2, TEK, EGFR, RELA, IGF1R 5.4414
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, CACNA1C, DRD1, DRD2, DRD3, GRIA4 4.8851
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.6484
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, EGFR, RELA, IGF1R 4.6957
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1, F3, RELA 4.4307
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, MAP2K1, INSR, GRM8, GRM1, EGFR 4.6317
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, INSR, KDR, BCL2, TEK, MET, EGFR, RELA, IGF1R 3.9674
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.8851
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, DUSP3, CACNA1C, MAP3K7, EGFR, RELA, CDC25B, HSPA1A 4.0085
Metabolic pathways_Homo sapiens_hsa01100 MAOA, HSD17B3, AKR1B1, TYR, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 3.9076
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, CACNA1C, DRD1, GRIA4 4.1438
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, BCL2, MET, EGFR, IGF1R 3.8105
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, MAP2K1, CACNA1C, GRM1 4.1596
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, SMAD3, INSR, GRM1, EGFR, IGF1R 3.8392
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SMAD3, SRC, BCL2, MMP9, RELA 3.6513
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.6328
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C, EGFR 3.6216
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, INSR, ADORA1, CACNA1C, ADRA1A 3.3752
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.2256
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, GRM1, GRIA4 3.417
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA, HSPA1A 3.153
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, BCL2, ADORA1, RELA 3.1291
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.2942
Long-term depression_Homo sapiens_hsa04730 GRIA2, MAP2K1, GRM1, IGF1R 3.2256
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PGR, CDC25B, IGF1R 2.5084
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.4073
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, SMAD3, EGFR, RELA 3.0984
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, MAP3K7, RELA, HSPA1A 2.2264
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, BCL2, CACNA1C 2.3402
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.3467
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA, RELA 2.3532
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET, EGFR 3.0829
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, MAP3K7, RELA 2.585
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, EGFR, IGF1R 3.0226
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR, RELA 3.0675
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, PGR, IGF1R 2.1997
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.8196
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, MAP3K7, ADRA1A, IGF1R 2.1943
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2 3.0615
Measles_Homo sapiens_hsa05162 CSNK2A1, MAP3K7, RELA, HSPA1A 2.0911
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0615
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, EGFR 1.8851
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA, DRD1, DRD2 1.7265
Taste transduction_Homo sapiens_hsa04742 HTR1A, CACNA1C, GRM1 1.8374
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC, EGFR 1.7932
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, RELA, IGF1R 1.7183
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.6859
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, SMAD3, RELA 1.9743
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.7115
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, RELA 1.9846
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.2264
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2437
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.6203
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2674
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.1478
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.6321
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, BCL2, RELA 1.4965
Glioma_Homo sapiens_hsa05214 MAP2K1, EGFR, IGF1R 2.0971
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.359
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.4021
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1025
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3066
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR, RELA 1.3984
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C, ADRA1A 1.4965
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1, INSR 1.3625
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3433
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.3433
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, SMAD3, IGF1R 1.3566
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3093
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, SMAD3, BCL2 2.1348
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, MAP3K7 1.3566
Axon guidance_Homo sapiens_hsa04360 MET 0.3581
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C, ADRA1A 1.3234
Platelet activation_Homo sapiens_hsa04611 SRC 0.3688
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, RELA 0.4623
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA, RELA 1.3096
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.5638
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.0971
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6815
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4302
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4311
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA, HSPA1A 1.1922
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.1777
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6826
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7183
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.1476
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC, EGFR 1.0202
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4439
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4427
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.4488
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7894
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7983
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4578
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4578
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.1398
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4623
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4578
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4608
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4578
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4623
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4578
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8642
Peroxisome_Homo sapiens_hsa04146 XDH 0.4628
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4661
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8938
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC 0.8938
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4628
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.477
Pertussis_Homo sapiens_hsa05133 RELA 0.4857
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4789
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4878
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 1
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, RELA 0.9805
Bile secretion_Homo sapiens_hsa04976 CA2 0.4974
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4878
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5106
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, EGFR 0.9991
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0659
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0644
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0795
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5303
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, RELA 1.0936
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.1951
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1546
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.1951
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1484
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.2205
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2205
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.2592
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.2716
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2674
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RELA 1.2674
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, EGFR 1.3823
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, EGFR 1.3493
Legionellosis_Homo sapiens_hsa05134 RELA, HSPA1A 1.3566
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6191
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3393
Malaria_Homo sapiens_hsa05144 MET 0.624
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3201
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGES 1.2929
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3934
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, CACNA1C 1.4285
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4585
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.575
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6949
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5591
Prion diseases_Homo sapiens_hsa05020 MAP2K1, HSPA1A 1.6442
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7345
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1, EGFR 1.8119
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8088
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7894
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.6442
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7029
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8088
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6313
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8441
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9303
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8318
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8703
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9991
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0645
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1283


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)