TCM Prescription: Fu Wei San Capsules



Prescription Description
Prescription IDTCMF3436
Pinyin NameFu Wei San Jiao Nang
Chinese Name复胃散胶囊
English NameFu Wei San Capsules
Function Description吐血, 便血, 胃脘痛
IndicationsStomach ache disorder, Melena, Hematemesis
Disease ICD-11 Category SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1) ];
ME24.A4 [Melaena, 黑便 ];
ME24.A5 [Haematemesis, 呕血 ];
Human Tissues Associated with IndicationStomach, Intestine
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH72 Bletilla striata 白芨 TCMH72 ITSAJ4380-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH789 Lonicera japonica 海螵蛸 TCMH789 ITSAI3881-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.80059
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 8.17773
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, F10, F3, FABP3, FABP4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, TNKS, TNKS2, XDH 7.44748
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.43156
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.21202
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.21202
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A 7.14486
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.13808
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, HSD11B2, HTR5A, TYR 6.27401
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, HTR2A, HTR2B, HTR6, PTPN1, TNKS, TNKS2, XDH 6.27401
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, HTR2A, HTR2B, HTR6, PTPN1, TNKS, TNKS2, XDH 6.26248
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, GBA2, HTR1A, TYR 6.14121
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 6.10707
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 5.96042
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR 5.90657
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.84327
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR5A, TYR 5.685
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.65088
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CDK6, DRD1, DRD2, DRD3, HTR2A, HTR2B, TNKS, TNKS2 5.61078
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B 5.58773
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR5A, TYR 5.56835
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.34977
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.16718
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.15523
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, HTR5A, TYR 5.14117
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.14117
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 5.0598
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, HTR1A, HTR2A, HTR2B, XDH 5.04923
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 5.00741
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR5A, TYR 4.9765
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 4.92047
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.78558
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.78558
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.78081
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, GBA2, HTR2B, TYR, XDH 4.76966
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSD11B2, HTR2A, HTR2B 4.69816
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.69701
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.65188
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.63646
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.62459
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.60213
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.60213
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 4.48905
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 4.48905
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, TNKS, TNKS2 4.44242
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B 4.41861
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3 4.40785
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B 4.40303
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HTR5A 4.39452
[BP] GO:0050801 ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, HTR2A, HTR2B 4.32991
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.27033
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2 4.21346
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 4.21346
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, HTR2A, HTR2B, HTR6, PTPN1, TNKS, TNKS2, XDH 4.19393
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, HTR1A, HTR2A, HTR2B, HTR6, PTPN1, TNKS, TNKS2, XDH 3.99094
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2B, PTPN1, TNKS, TNKS2, TYR, XDH 3.95017
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, BCL2, CA2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, SIGMAR1, TNKS2, TYR 3.94674
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, HTR1A, HTR2A, HTR2B, HTR6, PTPN1, TNKS, TNKS2, XDH 3.94674
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.92327
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F3, HTR1A, HTR2A, HTR2B, HTR6, PTPN1, TNKS, TNKS2, XDH 3.91356
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.8475
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALPL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, TNKS2, TYR 3.82951
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, HTR5A, SIGMAR1, TYR 3.793
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.74034
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2 3.70624
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.69917
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, CA2, DRD1, DRD2, DRD3, ESR1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.67923
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.65313
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.65313
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.63384
[BP] GO:0035265 organ growth ADRA1A, BCL2, CYP19A1, ESR1 3.59621
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 3.59621
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, BCL2, CYP1B1, DRD2, F10, F3, HTR2A, HTR2B, HTR6, PTPN1, XDH 3.55679
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.54772
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, HSD11B2, HTR5A 3.53036
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.51549
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD2, DRD3, FABP3 3.51549
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HTR1A, HTR2A, HTR2B, HTR6, PTPN1, TNKS, TNKS2, XDH 3.5074
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESRRA, F10, F3, FABP4, HTR2A, HTR2B, HTR6, PTPN1, TNKS, TNKS2, XDH 3.46777
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.45903
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 3.45292
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B 3.45292
[BP] GO:0048513 animal organ development ACHE, ADRA1A, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, TYR 3.41694
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.39198
[BP] GO:0030003 cellular cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.3746
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, DRD1, DRD2, DRD3, TNKS, TNKS2 3.36853
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.33669
[BP] GO:0006873 cellular ion homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.29809
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.27974
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, ESR1, F3, HTR1A, HTR2A, HTR2B 3.27025
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 3.12255
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.08262
[BP] GO:0060134 None DRD1, DRD2, DRD3 3.08262
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 3.08262
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 3.07505
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 3.07505
[BP] GO:0055080 cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.04896
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, F10, F3, FABP3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, PTPN1, TYR 3.01735
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 3.00654
[BP] GO:0051580 None DRD1, DRD2, DRD3 3.00654
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 3.00654
[BP] GO:0009115 None AOX1, XDH 2.98054
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.97759
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP3, FABP4, FUT7, GBA2 2.96561
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.96561
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.9361
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.93378
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR2B, PTPN1, TNKS, TNKS2, TYR, XDH 2.91673
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.90428
[BP] GO:0055074 calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.88995
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.87193
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.87193
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.87193
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.86351
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3 2.84353
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, HSD11B2, HTR2A, HTR2B, TYR 2.84353
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, BCL2, CYP1B1, DRD1, DRD2, DRD3, HSD11B2, HTR1A, HTR2A, HTR2B, HTR7, TYR 2.80156
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD2, DRD3, FABP3 2.77326
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.77151
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, PTPN1, SIGMAR1, TNKS, TNKS2 2.76548
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, F10, F3, HTR2A, HTR2B, HTR6, PTPN1, XDH 2.75172
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.74709
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.74587
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.74587
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.74501
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.74281
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A 2.7093
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.68176
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.64701
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.64701
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.62617
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3 2.62386
[BP] GO:0046110 None AOX1, XDH 2.61624
[BP] GO:0060160 None DRD2, DRD3 2.61624
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.61624
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.61624
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.5869
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.5842
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.58047
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.58047
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.53827
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, HTR2A, HTR2B, PTPN1, XDH 2.51031
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, HTR2A, HTR2B, PTPN1, XDH 2.51031
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, HTR1A, HTR2A, HTR2B, PTPN1 2.50043
[BP] GO:0010035 response to inorganic substance AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4 2.48847
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B 2.48138
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.47725
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.47725
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, DRD3, TNKS2 2.47659
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR1A, HTR2A 2.47575
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2B, TYR, XDH 2.43261
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.43261
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.43261
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, HTR2A 2.40777
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, HTR2B, HTR5A 2.40167
[BP] GO:0007267 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 2.39152
[BP] GO:0019725 cellular homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.38967
[BP] GO:0051302 None CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.38662
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.37984
[BP] GO:0070213 None TNKS, TNKS2 2.37984
[BP] GO:0006145 None AOX1, XDH 2.37984
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.37984
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.37984
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, GBA2, XDH 2.3647
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.35146
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2A, HTR2B, PTPN1, TNKS, TNKS2, XDH 2.35011
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, HSD11B2 2.32106
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, F10, F3, FABP4, HTR2A, HTR2B, HTR6, PTPN1, TNKS, TNKS2, XDH 2.32044
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B 2.3047
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B 2.30289
[BP] GO:0090066 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 2.27559
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.26798
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.26798
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3 2.25673
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A 2.24522
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, GBA2, XDH 2.21057
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, HTR2A, HTR2B, PTPN1, TNKS, XDH 2.21057
[BP] GO:0021853 None DRD1, DRD2 2.20542
[BP] GO:0043696 None CDK6, ESRRB 2.20542
[BP] GO:0043697 None CDK6, ESRRB 2.20542
[BP] GO:0090325 None DRD2, DRD3 2.20542
[BP] GO:0007598 None F10, F3 2.20542
[BP] GO:1904936 None DRD1, DRD2 2.20542
[BP] GO:0042321 None ADORA1, DRD2 2.20542
[BP] GO:0010513 None HTR2A, HTR2B 2.20542
[BP] GO:0002209 None BCL2, DRD1, HTR1A 2.20542
[BP] GO:0001662 None BCL2, DRD1, HTR1A 2.20542
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.19055
[BP] GO:0030336 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD2 2.18161
[BP] GO:0051781 None CDC25B, DRD2, DRD3, HTR2B 2.17611
[BP] GO:0045777 None ADORA1, ADRA1A, HSD11B2 2.17071
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.17071
[BP] GO:0060191 regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.16119
[BP] GO:0022029 None DRD1, DRD2, HTR6 2.13559
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.13559
[BP] GO:0042596 None BCL2, DRD1, HTR1A 2.13559
[BP] GO:0023052 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 2.10898
[BP] GO:0007154 None ADORA1, ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 2.10627
[BP] GO:0055065 metal ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.09514
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A 2.09514
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, BCL2, CDK6, CYP1B1, DRD2, FABP3, XDH 2.09207
[BP] GO:0044242 None AKR1B10, CYP1B1, FABP3, FABP4, GBA2 2.08123
[BP] GO:0051588 None DRD1, DRD2, DRD3, HTR1A 2.08123
[BP] GO:2000146 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD2 2.07542
[BP] GO:0021843 None DRD1, DRD2 2.07335
[BP] GO:0046113 None AOX1, XDH 2.07335
[BP] GO:0021830 None DRD1, DRD2 2.07335
[BP] GO:0021826 None DRD1, DRD2 2.07335
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.07335
[BP] GO:0048511 rhythmic process BCL2, CSNK2A1, DRD2, DRD3, ESR1, HTR7 2.05618
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B 2.04941
[BP] GO:0021885 forebrain cell migration DRD1, DRD2, HTR6 2.04862
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3 2.03406
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2 2.03406
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2B, PTPN1, TNKS, TNKS2, TYR, XDH 2.01715
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, PTPN1, XDH 2.01715
[BP] GO:0043112 None ACHE, DRD2, DRD3, HTR2B 2.01715
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, PTPN1, XDH 2.00615
[BP] GO:0007268 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.00583
[BP] GO:0098916 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.00583
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR2A, HTR2B, PTPN1, TNKS, TNKS2, XDH 2.00524
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, CA4, DRD1, DRD2, DRD3, F10, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.70015
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALPL, BCL2, CA12, CA14, CA2, CA4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, PTPN1, SIGMAR1, TYR 3.3611
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALPL, BCL2, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, PTPN1, SIGMAR1, TNKS, TNKS2, TYR 3.33725
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, SIGMAR1 3.12255
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, F10, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1, SIGMAR1 3.07058
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, AOX1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F10, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR5A, PTPN1, SIGMAR1, TNKS, TNKS2, TYR, XDH 2.86113
[CC] GO:0031233 None CA4, F10, F3 2.62617
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 2.20644
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.47869
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.12177
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.99072
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.43156
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, PTPN1, TNKS, TYR, XDH 7.42671
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.21202
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.21202
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.14219
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.14219
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, PTPN1, TNKS, TNKS2, TYR, XDH 6.14121
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.14121
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, PTPN1, TNKS, TNKS2, TYR, XDH 5.99808
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.685
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.60483
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.51955
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.51142
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.38345
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.38345
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 5.34977
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, CDK6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 5.15523
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.7166
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 4.69206
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.44242
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.40303
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 4.23188
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 4.19893
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 4.18493
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 4.00705
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.74034
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.74034
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.64308
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, F10, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 3.59621
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 3.20166
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.18906
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, F3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.18906
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.17279
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B2, HSD17B1, XDH 3.08262
[MF] GO:0035240 None DRD1, DRD2, DRD3 3.08262
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 3.04386
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.98054
[MF] GO:0003845 None HSD11B1, HSD11B2 2.98054
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, PTPN1, TNKS 2.91868
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.90428
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.90428
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.87746
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.86113
[MF] GO:0008289 lipid binding ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1 2.84599
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.64701
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.62617
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.57771
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.44424
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.37984
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.20542
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2D6 2.07335
[MF] GO:0004064 arylesterase activity CA1, CA2 2.07335
[MF] GO:0043546 None AOX1, XDH 2.07335


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.8407
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, HTR7, ADORA3, HTR2B, ADORA1, HTR1A, HTR2A, DRD1, HTR5A, DRD2, ADRA1A, DRD3 9.7652
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.8407
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, HTR2B, HTR1A, HTR2A, HTR5A 6.3938
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 5.4052
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A 5.1541
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.5474
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 4.7201
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.3976
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, ADORA1, HTR1A, DRD1, DRD2 2.8798
Gap junction_Homo sapiens_hsa04540 HTR2B, HTR2A, DRD1, DRD2 3.1557
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.205
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.3187
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1 2.2729
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7091
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.6625
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, CYP1B1, CDC25B 1.4955
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1A 1.4263
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4263
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7091
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.2731
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4955
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7737
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4007
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 HTR2B, HTR2A 1.1135
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, F3 1.109
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.2731
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4 1.2865
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1775
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7089
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1447
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7428
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.045
Estrogen signaling pathway_Homo sapiens_hsa04915 ESR1, ESR2 1.1135
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.2333
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9776
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1397
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.9281
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2 0.8931
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9792
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9045
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRA1A 0.8921
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.8514
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.8097
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7366
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, BCL2 0.5339
Pathways in cancer_Homo sapiens_hsa05200 CDK6, BCL2 0.4905
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.5473
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.5325
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.5082
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4078
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4648
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3122
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5569
Purine metabolism_Homo sapiens_hsa00230 XDH 0.399
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5303
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.3691
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.5243
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.4927
Proteoglycans in cancer_Homo sapiens_hsa05205 ESR1 0.3691
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4927
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.3691
Rap1 signaling pathway_Homo sapiens_hsa04015 DRD2 0.3638
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4648
Ras signaling pathway_Homo sapiens_hsa04014 HTR7 0.3445
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3903
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.399
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4648
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.4927
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.4648
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5339
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5473
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5899
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4648
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A 0.4905
Glioma_Homo sapiens_hsa05214 CDK6 0.5976
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5339
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.5473
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.4927
Melanoma_Homo sapiens_hsa05218 CDK6 0.5938
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5976
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5899
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5976
Peroxisome_Homo sapiens_hsa04146 XDH 0.5569
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6014
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5976
Bile secretion_Homo sapiens_hsa04976 CA2 0.5938
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6353
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5938
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6847
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6659
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6834
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6847
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6847
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7366
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8097
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8286
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8286
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.848
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.841
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.205
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9454
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0311
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2731


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)