TCM Prescription: Bao Xin Ning Capsules



Prescription Description
Prescription IDTCMF3421
Pinyin NameBao Xin Ning Jiao Nang
Chinese Name保心宁胶囊
English NameBao Xin Ning Capsules
Function Description胸痹
IndicationsChest pain
Disease ICD-11 Category MD30.Z [Chest pain, unspecified, 胸痛,未特指的 ];
Human Tissues Associated with IndicationHeart, Lung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH408 Salvia miltiorrhiza 丹参干浸膏 TCMH408 ITSAH2408-14
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH422 Angelica sinensis 当归干浸膏 TCMH422 ITSAF173-14
TCMH2619 Citrus aurantium 枳壳干浸膏 TCMH2619 ITSAA1279-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9733
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.2014
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, TBXAS1, TYR, XDH 9.66568
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, FABP3, FABP4, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 8.6149
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.17467
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC6A4, SRC, TBXAS1, TERT, TYR, XDH 7.62053
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, ESR1, HSD17B1, HSD17B2 7.59976
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TBXAS1 7.54294
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 7.30815
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TBXAS1 7.30815
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC6A4, SRC, TBXAS1, TERT, TYR, XDH 6.99064
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, POLB, PPARA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 6.99064
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA, TBXAS1 6.80844
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TBXAS1 6.46843
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TBXAS1 5.91531
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, POLB, PPARA, RORC, SLC6A4, SRC, TYR 5.85793
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, RORC 5.66284
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, POLB, PPARA, RORC, SLC6A4, SRC, TYR 5.46271
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, RORC, SLC6A4, SRC, TYR 5.36279
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, FABP4, MET, PPARA, TBXAS1 5.36279
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.31587
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 5.01434
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.98773
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SLC6A4, SRC, TERT, XDH 4.95439
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KCNH2, KDR, MET, POLA1, POLB, PPARA, SLC6A2, SLC6A4, SRC, TERT, XDH 4.86921
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TBXAS1 4.79719
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA, TBXAS1 4.75959
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.59133
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA6, CA9, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 4.42335
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.40339
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 4.24088
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.23329
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, POLB, PPARA, SRC, TYR 4.21508
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.21508
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PPARA, SLC6A4, SRC 4.21248
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.21248
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.1149
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT 4.03733
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, PPARA, SLC6A4, SRC 3.80929
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, RORC, SLC6A4, SRC, TYR 3.77994
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, TBXAS1, TYR 3.75875
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 3.66919
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2 3.66727
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 3.65359
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, RORC, SLC6A4, SRC, TERT 3.63778
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 3.63778
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.50856
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, XDH 3.50554
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.50258
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, POLA1, POLB, SRC, TERT 3.50258
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, POLA1, POLB, PTPN1, RORC, SLC6A4, SRC, TERT 3.50027
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.50027
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.50027
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.49608
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, TBXAS1, TYR 3.34577
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 3.33802
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, TBXAS1, TYR 3.26879
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 3.19793
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA9, CDC25B, CES1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, POLB, PPARA, RORC, SLC6A4, SRC, TERT, TYR 3.18124
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TBXAS1, TERT, TYR, XDH 3.18124
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.089
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TYR 3.0635
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 3.05553
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KCNH2, KDR, POLB, SLC6A2, SLC6A4, SRC 3.04577
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, XDH 2.99993
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, POLB, PPARA, SLC6A4, SRC, TERT 2.98757
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 2.98757
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TBXAS1, TERT, TYR, XDH 2.93095
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CES1, CYP1A1, CYP1B1, KDR, POLB, SLC6A4, SRC 2.89721
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.82219
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.71346
[BP] GO:0009115 None AOX1, XDH 2.67555
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.63013
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.57615
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, KCNH2, PPARA, SLC6A2, SLC6A4 2.54866
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 2.50655
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 2.46833
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.46833
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.45048
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.41255
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TBXAS1, TERT, TYR, XDH 2.40711
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.35868
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.34937
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.34653
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.3355
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.3355
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SLC6A4, SRC 2.29788
[BP] GO:0046110 None AOX1, XDH 2.29302
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.29302
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.29155
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.28457
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.28457
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.26213
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 2.24873
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.24873
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, RORC, SLC6A4, SRC 2.23729
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.23674
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.15369
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, ESR1, FLT3, MET, PIM1, POLA1, SRC, TYR 2.15109
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PIM1, POLB, PPARA, RORC, SRC, TYR 2.15095
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.15046
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.15046
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.15046
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19 2.13918
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.11844
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.11844
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.11844
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, SRC, TERT 2.11844
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.11334
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.11334
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD17B1, HSD17B2 2.11041
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, HCAR2, KCNH2, MMP12, SLC6A4, SRC, TERT 2.10659
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.09128
[BP] GO:0006145 None AOX1, XDH 2.08852
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.08852
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.08852
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.08301
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.07658
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.76636
[CC] GO:0044432 endoplasmic reticulum part CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FLT3, HSD17B2, PTPN1, TBXAS1 1.62212
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KCNH2, KDR, MMP2, MMP9, PIM1, POLA1, PTPN1, SLC6A4, SRC, TBXAS1, TERT, TYR, XDH 1.49907
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9 1.48986
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, ESR1, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT 1.06441
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TBXAS1, TYR, XDH 20.0829
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.6828
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 11.3961
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TBXAS1, TERT, TYR, XDH 11.3138
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.2148
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TERT, TYR, XDH 10.3446
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TBXAS1, TERT, TYR, XDH 9.38183
[MF] GO:0046872 metal ion binding ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TBXAS1, TERT, TYR, XDH 8.97068
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 8.97068
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TBXAS1, XDH 8.23027
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 7.62617
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TBXAS1, TYR 7.59976
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.76253
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, SRC, TBXAS1 6.58217
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, SRC, TBXAS1 6.32091
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 6.12788
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TBXAS1, TYR 5.91531
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HSD17B1, POLA1, SRC, TBXAS1, XDH 5.57649
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19 5.38792
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.27074
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.22286
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.22286
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.78244
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19 4.46845
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 3.9028
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 3.79367
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 3.47326
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 3.43833
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SLC6A4, SRC 3.41964
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.34577
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 2.93095
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.89721
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 2.85587
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 2.68581
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.67555
[MF] GO:0008389 None CYP2A13, CYP2A6 2.67555
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.60147
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, POLA1, POLB, SRC, TERT 2.44579
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.40711
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.40711
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 2.37439
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.3355
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.3355
[MF] GO:0005330 None SLC6A2, SLC6A4 2.29302
[MF] GO:0047374 None CES1, CES2 2.29302
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.24873
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.15369
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, SLC6A4, TERT, TYR, XDH 2.14774
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA, RORC 2.08852
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.08852
[MF] GO:0032795 None ADORA1, ADRA2A 2.08852


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.9897
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.937
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.9698
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP2C19, CYP19A1, POLA1, CYP2A6, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 4.7149
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP2C19 5.183
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.3266
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.3266
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3266
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0529
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.8652
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0508
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.8864
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.3549
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP2C19 3.3109
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3109
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.0188
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, CYP2C19 2.1644
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0188
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.8726
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, ADORA1, PPARA 1.7486
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8726
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.155
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.7486
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.7165
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, CYP2C19, SLC6A4 1.6702
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4787
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, ADORA3, ADORA1, ADRA2A 1.393
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA2A 1.3076
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, KDR, MET, IGF1R 1.2094
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.049
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3298
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3278
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3076
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.003
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0573
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3116
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2269
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.253
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0175
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE 0.9469
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9274
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2516
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9523
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.171
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9154
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9248
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8024
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9248
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.7486
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9201
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8156
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8726
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7397
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8239
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7657
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6144
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7097
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6702
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.6087
HTLV-I infection_Homo sapiens_hsa05166 POLB, TERT 0.5297
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7165
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6603
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2557
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3215
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2 0.3468
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4844
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3421
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3468
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3421
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3935
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3822
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4177
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4338
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4844
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4215
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4107
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4141
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4599
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4844
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4338
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4215
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4779
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4802
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4338
Gap junction_Homo sapiens_hsa04540 SRC 0.4844
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4752
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4832
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4844
Axon guidance_Homo sapiens_hsa04360 MET 0.4295
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4389
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4844
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4779
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4844
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4844
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4832
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4832
Peroxisome_Homo sapiens_hsa04146 XDH 0.4844
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4725
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4832
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5174
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5402
Glioma_Homo sapiens_hsa05214 IGF1R 0.5402
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5421
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5281
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5402
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5399
Bile secretion_Homo sapiens_hsa04976 CA2 0.528
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5402
Shigellosis_Homo sapiens_hsa05131 SRC 0.5402
Malaria_Homo sapiens_hsa05144 MET 0.6105
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6144
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6124
DNA replication_Homo sapiens_hsa03030 POLA1 0.7097
Base excision repair_Homo sapiens_hsa03410 POLB 0.7321
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7657
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7645
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7867
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.253


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)