TCM Prescription: Fu Ming Tablets



Prescription Description
Prescription IDTCMF3411
Pinyin NameFu Ming Pian
Chinese Name复明片
English NameFu Ming Tablets
Function Description青光眼, 视瞻昏渺
IndicationsGlaucoma
Disease ICD-11 Category 9C61 [Glaucoma, 青光眼 ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1294 Cornu saigae tataricae 羚羊角 TCMH1294
TCMH1024 Tribulus terrestris 蒺藜 TCMH1024 ITSAJ4258-14
TCMH1535 Equisetum hiemale 木贼 TCMH1535
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH2244 Prunella vulgaris 夏枯草 TCMH2244 ITSAH2424-14
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH1933 Herba dendrobii 石斛 TCMH1933
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1937 Concha haliotidis 石决明 TCMH1937
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH699 Eriocaulon buergerianum 谷精草 TCMH699
TCMH718 Aristolochia manshuriensis 关木通 TCMH718 GBVE2055-11
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, EPHX2, ESR1, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, KDR, MAOA, MET, NISCH, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, SLC1A1, SRC, TNKS, TNKS2, XDH 11.8427
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EPHX2, ESR1, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 11.2647
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 8.90677
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 8.41066
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, GRM1, GRM3, GRM5, GRM8 8.41062
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EPHX2, FABP3, FDPS, FUT7, GLO1, HMGCR, NISCH, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.3608
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 8.3378
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 7.79683
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, MAOA, NQO2, PHF8, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.75487
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 7.75295
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HASPIN, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 7.60935
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.56835
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 7.56835
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 7.30225
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EPHX2, FABP3, FABP4, FDPS, FUT7, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 7.27799
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, FDPS, FLT3, HASPIN, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TNKS, XDH 7.13391
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TOP2A, XDH 6.97755
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC, TOP2A, XDH 6.95673
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.94744
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, GRM1, GRM3, GRM5, GRM8 6.94744
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.92706
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, SRC, TNKS 6.81958
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, FDPS, FLT3, HASPIN, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TNKS, XDH 6.73784
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DYRK1A, DYRK1B, DYRK2, EPHX2, ESR1, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, XDH 6.70755
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, TOP2A, XDH 6.48309
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DYRK1A, DYRK1B, DYRK2, ESR1, F10, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 6.45758
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK1A, DYRK2, DYRK3, ESR1, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.43948
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PRKCA, PTGS2, RORC, SRC, TYR 6.43451
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, GRM1, GRM3, GRM5, GRM8 6.35757
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 6.35131
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK1A, DYRK2, DYRK3, ESR1, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.35131
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HASPIN, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP2, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 6.35131
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.32899
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.27183
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.27183
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, GRIK5, GRM1, GRM3, GRM5, GRM8, NISCH, PTGS2 6.24457
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, GRIK5, GRM1, GRM3, GRM5, GRM8, NISCH, PTGS2 6.24457
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK1A, DYRK1B, DYRK3, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, RORC, SRC, TNKS2, TOP2A, TYR 6.13172
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TNKS 6.11251
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, PTGS1, PTGS2, TBXAS1 6.00426
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EPHX2, NQO2, PTGS1, RORC 5.97904
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 5.90525
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, NISCH, PRKCA, PTGS2, SRC 5.90029
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, ESR1, GRM5 5.65578
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, APP, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EPHX2, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PRKCA, PTGS2, RORC, SRC, TYR 5.60818
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 5.5978
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, GRM1, GRM3, GRM5, GRM8, PTGS2 5.50851
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.50564
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.50564
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 5.45119
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, EPHX2, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, PTGS2, RORC, SRC 5.44158
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HASPIN, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 5.42963
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.42952
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.42952
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 5.41707
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.41707
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, F3, FLT3, FUT7, GLO1, HASPIN, HMGCR, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 5.41707
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FLT3, HASPIN, IGF1R, KDR, MET, PRKCA, SRC, TNKS, TOP2A 5.34978
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, F10, F3, FABP3, FABP4, FDPS, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, XDH 5.27264
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HASPIN, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 5.11369
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DYRK1A, DYRK2, DYRK3, ESR1, F10, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 5.11369
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AXL, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK2, F10, F3, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC 5.08201
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.06345
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CDK6, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, NISCH, PRKCA, PTGS2, SRC 5.05378
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.05378
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CDK6, DRD1, HCAR2, HMGCR, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 5.05062
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 5.021
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.93816
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 4.90039
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 4.90039
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DRD1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 4.899
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC 4.88642
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, ESR1, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS1, PTGS2, SRC, XDH 4.85992
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, F10, F3, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.85567
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CHRM4, CSNK2A1, DYRK2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TNKS, TNKS2 4.81258
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, EPHX2, ESR1, F10, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TYR 4.78664
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC 4.77336
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, NISCH, PRKCA, PTGS2, SRC 4.77117
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, PRKCA 4.753
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, F10, F3, FLT3, GRM1, HMGCR, KDR, MET, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.74117
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FDPS, HMGCR 4.65107
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.62786
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CDK6, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, NISCH, PRKCA, PTGS2, SRC 4.61559
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SRC 4.60533
[BP] GO:0019371 None CBR1, PTGS1, PTGS2, TBXAS1 4.60018
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 4.59074
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR 4.47461
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 4.4441
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 4.4441
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FLT3, PTGS2, RORC, SRC, TYR 4.4441
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, PHF8 4.28813
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC, TNKS 4.28348
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, GLO1, PPARA, PTGS1, PTGS2, TBXAS1 4.28348
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, PIM1, SRC 4.28348
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM4, CHRM5, CLK1, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 4.28233
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC 4.22982
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.21953
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.18529
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CSNK2A1, CYP1B1, DRD1, DYRK2, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, NISCH, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2 4.14192
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, FDPS, HMGCR, MAOA, TYR 4.13377
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SRC 4.08383
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, EPHX2, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 4.08383
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2 4.04446
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, DRD1, EPHX2, HMGCR, PTGS2, SRC 4.03106
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FDPS 4.01054
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, PTGS2, RORC, SRC 3.99288
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, EPHX2, ESR1, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.98371
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, DRD1, EPHX2, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB, SRC 3.90638
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, CDC25B, CHRM5, DRD1, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, XDH 3.90389
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, CDC25B, CHRM5, DRD1, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, XDH 3.847
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 3.82405
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK2, EPHX2, ESR1, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR 3.77926
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, CDC25B, DRD1, DYRK1A, DYRK1B, DYRK2, ESR1, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.75893
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK2, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC, TOP2A 3.69302
[BP] GO:0018107 peptidyl-threonine phosphorylation CLK1, CSNK2A1, DYRK1A, HASPIN, PRKCA, TNKS 3.64748
[BP] GO:0097746 None ADORA1, CHRM1, CHRM3, DRD1, EPHX2, HMGCR, PTGS2 3.62191
[BP] GO:0035296 None ADORA1, CHRM1, CHRM3, DRD1, EPHX2, HMGCR, PTGS2 3.62191
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD1, DYRK1A, DYRK1B, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.6168
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.6003
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DYRK1A, DYRK3, ESR1, FABP3, FABP4, GLO1, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PHF8, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.54282
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, EPHX2 3.49765
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD1, EPHX2, HMGCR, KDR, SRC 3.47379
[BP] GO:0050880 None ADORA1, CHRM1, CHRM3, DRD1, EPHX2, HMGCR, PTGS2 3.45585
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, CDC25B, DRD1, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 3.45585
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, CDC25B, DRD1, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 3.45585
[BP] GO:0018210 peptidyl-threonine modification CLK1, CSNK2A1, DYRK1A, HASPIN, PRKCA, TNKS 3.45585
[BP] GO:0035150 None ADORA1, CHRM1, CHRM3, DRD1, EPHX2, HMGCR, PTGS2 3.44386
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.38384
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 3.3824
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CDC25B, CDK6, CHRM5, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DYRK1A, DYRK1B, DYRK2, EPHX2, ESR1, F3, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.33196
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, F10, F3, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.29972
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, F10, F3, FABP3, FABP4, FDPS, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, XDH 3.29972
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.28499
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, F3, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIM1, PPARA, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 3.27992
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DYRK1A, DYRK2, DYRK3, ESR1, FABP3, FABP4, GLO1, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PHF8, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.22063
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, DRD1, EPHX2, HMGCR, PTGS2, SRC 3.21908
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK1A, DYRK1B, ESR1, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PHF8, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 3.21908
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, EPHX2, MAOA 3.15839
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.15839
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PIK3CA, PIK3CB, SRC 3.14569
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, MET, PIK3CA, PIK3CB, SRC, XDH 3.14232
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.13892
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 3.13892
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, KDR, PTGS2, SRC 3.13266
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, DRD1, EPHX2, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB 3.12036
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, PIK3CA, PIK3CB, SRC 3.11561
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 3.11317
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, PHF8, PIK3CA, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 3.07454
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, PHF8, PIK3CA, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 3.07454
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, HASPIN, TNKS, TNKS2 3.06965
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EPHX2, FABP3, FABP4, FUT7, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.06925
[BP] GO:0016572 histone phosphorylation AURKB, DRD1, HASPIN, PRKCA 3.06193
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 3.02261
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.99752
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, MMP1, MMP2, PHF8, PIK3CA, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.97761
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CYP19A1, DYRK1A, DYRK3, ESR1, F3, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PRKCA, PTGS2, PTPN1, SRC, XDH 2.97141
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1 2.95019
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, PTGS2, SRC 2.94746
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.94746
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 2.94513
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.94513
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 2.93503
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, CLK1, DRD1, DYRK1A, PRKCA, SRC, TNKS 2.92976
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.91959
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CLK1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DYRK1A, DYRK1B, DYRK2, EPHX2, ESR1, F3, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.90818
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, PTGS2 2.90198
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, NISCH 2.86148
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, CDC25B, DRD1, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, XDH 2.82082
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 2.80801
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, CDC25B, DRD1, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.80801
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.80531
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 2.78971
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, PHF8, PIK3CA, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.78156
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.72802
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.72442
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.71572
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, PTGS2 2.71453
[BP] GO:0018209 peptidyl-serine modification AURKB, CLK1, DRD1, DYRK1A, PRKCA, SRC, TNKS 2.66803
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.66482
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, FLT3, GRM1, HMGCR, KDR, PIK3CB, PRKCA, PTPN1, SRC, XDH 2.65901
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PTGS2, SRC 2.64675
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.63133
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 2.61947
[BP] GO:1902532 negative regulation of intracellular signal transduction DYRK1A, DYRK3, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.61947
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.59811
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PHF8, PIK3CA, PPARA, SRC, TYR 2.58859
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.58252
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.57806
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CHRM1, CYP19A1, DRD1, DYRK2, GRIK5, GRM5, HCAR2, HMGCR, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC 2.56196
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.54662
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CDK6, CYP1A1, CYP1B1, DRD1, FABP3, HMGCR, KDR, PTGS2, SRC 2.53035
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, PPARA, PTGS2, SRC 2.52763
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.50892
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EPHX2, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.50719
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, CDC25B, DYRK1A, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.50459
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK1A, DYRK2, DYRK3, ESR1, F10, F3, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.47031
[BP] GO:0051937 None CHRM5, DRD1, NISCH 2.46738
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, DRD1, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, XDH 2.44322
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, CDC25B, CSNK2A1, DYRK1A, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.44181
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.4024
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.38811
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DYRK1A, ESR1, PPARA, RORC, SRC, TOP2A 2.37626
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DYRK1A, DYRK2, DYRK3, ESR1, F10, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.31697
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.31682
[BP] GO:0099566 None GRM1, GRM5 2.31682
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.31682
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.31682
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.31682
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.2973
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 2.29683
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, ESR1, F3, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PRKCA, PTGS2 2.29683
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, CDC25B, DYRK1A, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.2923
[BP] GO:0008217 None ADORA1, EPHX2, NISCH, PPARA, PTGS1, PTGS2 2.2923
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.26924
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, GRM5, IGF1R, MMP2, PTGS2, SRC 2.17081
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, DYRK2, HCAR2, HMGCR, MMP12, PRKCA, PTGS2, PTPN1, SRC 2.15121
[BP] GO:0042391 None ADORA1, APP, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.13366
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, CHRM1, CHRM3, F10, F3, MET, PRKCA, XDH 2.13366
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.11704
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.11338
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CLK1, CSNK2A1, CYP1B1, CYP2D6, DRD1, DYRK1A, DYRK1B, DYRK2, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.1131
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, TYR 2.1131
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.07989
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.07386
[BP] GO:0015844 None CHRM5, DRD1, NISCH 2.07386
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, FLT3, GRM1, HMGCR, IGF1R, KDR, PIK3CB, PRKCA, PTPN1, SRC, XDH 2.07087
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.06793
[BP] GO:0070213 None TNKS, TNKS2 2.06793
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.06793
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.06793
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.06009
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 2.05796
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.00698
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, GRM1, HCAR2, PRKCA, PTGS2, SLC1A1 2.00698
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.00025
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC 5.95401
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 5.56576
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, ESR1, F10, F3, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP2, NISCH, PHF8, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TYR 4.92816
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 4.65107
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, F10, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 4.52289
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CSNK2A1, DRD1, ESR1, F10, F3, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, NISCH, PIK3CA, PIK3CB, PIM1, PRKCA, PTPN1, SLC1A1, SRC 4.49019
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 4.04446
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 3.17356
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, ESR1, F10, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MAOA, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TBXAS1, TYR 3.13892
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, F10, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTGS2, SLC1A1, SRC 3.07319
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 2.97749
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC 2.78606
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CBR1, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM5, HASPIN, HMGCR, IGF1R, KDR, MAOA, MMP12, MMP2, MMP9, NISCH, NQO2, PHF8, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.75736
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, F10, FLT3, GRIA2, HMGCR, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 2.66803
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, GRIA2 2.60707
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SRC 2.60213
[CC] GO:0014069 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.50294
[CC] GO:0099572 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.50294
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP12, MMP2, MMP9, NISCH, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 2.46789
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SRC 2.32231
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CA9, CBR1, CDK6, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HASPIN, HMGCR, IGF1R, KDR, MAOA, MMP12, MMP2, MMP9, NISCH, NQO2, PHF8, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.29448
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, GRIA2, HMGCR, HSD11B1, HSD17B2, PTGS1, PTGS2, TBXAS1 2.19558
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, GRIA2, GRIA4, GRIK5, GRM3, PTGS1, SRC 2.12821
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, GRIA2, GRIA4, GRIK5, GRM3, PTGS1, SRC 2.12821
[CC] GO:0031233 None CA4, F10, F3 2.12821
[CC] GO:0005783 None ADORA1, APEX1, APP, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, HMGCR, KDR, PRKCA, PTGS2, PTPN1, XDH 2.10214
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK2, DYRK3, EPHX2, ESR1, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD17B1, HSD17B2, KDR, MAOA, MMP2, MMP9, NISCH, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 2.06793
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, GRIK5 2.06793
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, F10, F3, FDPS, FLT3, FUT7, GLO1, HASPIN, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 15.0817
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DYRK2, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PPARA, PRKCA, PTPN1, RORC, TBXAS1, TNKS, TYR, XDH 13.3221
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, F10, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HASPIN, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 12.9251
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, MAOA, NQO2, PHF8, PTGS1, PTGS2, TBXAS1, TYR, XDH 9.14839
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.1368
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, SRC, TOP2A 8.90677
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 8.41066
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM5 8.3378
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.51388
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK2, DYRK3, EPHX2, ESR1, F10, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 7.27799
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PHF8, PTGS1, PTGS2, TBXAS1, TYR 6.94859
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 6.59715
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.37762
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.37238
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 6.35757
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, SRC 6.32899
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.13172
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DYRK2, DYRK3, EPHX2, ESR1, F10, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 6.10293
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.10017
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 6.09582
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 5.9854
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PHF8, TBXAS1, XDH 5.90525
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PPARA, PRKCA, PTPN1, RORC, TNKS 5.78661
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.69085
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 5.51084
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 5.46016
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TBXAS1, TYR 5.42952
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 5.39665
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 5.21608
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 5.05099
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 4.99184
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 4.99184
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD17B1, NQO2, PTGS1, PTGS2, SRC, TBXAS1, XDH 4.97801
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 4.90039
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC 4.53345
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 4.53345
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.48676
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 4.41948
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 3.90638
[MF] GO:0043168 anion binding APP, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, F3, FABP3, FABP4, FLT3, HASPIN, HMGCR, HSD17B1, IGF1R, KDR, MET, NISCH, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SLC1A1, SRC, TOP2A, XDH 3.87435
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, HASPIN, PIK3CA, PIM1, PRKCA 3.76819
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 3.73148
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, HASPIN, HMGCR, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SLC1A1, SRC, TOP2A, XDH 3.39991
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, F3, FLT3, HASPIN, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIM1, PRKCA, PTPN1, SRC 3.17356
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 3.12688
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.06965
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 2.97749
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 2.95279
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A 2.93755
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.82381
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A 2.80801
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A 2.77728
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2D6, CYP3A4 2.77465
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.71572
[MF] GO:0000166 nucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HMGCR, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A, XDH 2.68748
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HMGCR, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP2A, XDH 2.68583
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.55249
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NQO2 2.42164
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, EPHX2, PTPN1 2.38837
[MF] GO:0035173 histone kinase activity AURKB, HASPIN, PRKCA 2.31682
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.31682
[MF] GO:0099583 None GRM1, GRM5 2.31682
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.30255
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.18734
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.18734
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.06793
[MF] GO:0004971 None GRIA2, GRIA4 2.06793
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.06793
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EPHX2, ESR1, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 2.05796
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.00698


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, CHRM4, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD1, GRIA4 9.841
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.4811
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.0123
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM4, CHRM5, PRKCA, PIK3CB 7.2115
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.066
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 7.1874
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, MAOA, EPHX2, AKR1B1, HMGCR, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 6.3203
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PRKCA, PIK3CB, MMP9, MET, ESR1, IGF1R 6.2894
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, PIK3CA, ADORA1, PIK3CB, DRD1, PPARA, GRIA4 6.3203
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.1776
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1 5.3965
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.5547
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PRKCA, PIK3CB, PTGS2 5.3965
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.8652
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, MET, IGF1R 4.7854
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, EPHX2, TBXAS1, PTGS2, PTGS1 5.3838
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, PRKCA, DRD1, GRM1 4.8022
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, CYP2D6, ALOX5, PRKCA, PTGS2, PTGS1 5.0963
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, GRM8, PRKCA, PIK3CB, GRM1 4.4387
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PRKCA, PIK3CB, F3 4.297
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM4, CHRM5, PIK3CB 4.3146
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, PIM1, CYP1B1, PRKCA, PTGS2, MMP9, MET, CDC25B 4.2314
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PRKCA, PTGS2, GRM1, GRIA4 4.297
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, PIK3CA, KDR, PRKCA, PIK3CB, MET, IGF1R 3.8398
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PRKCA, PIK3CB, IGF1R 4.0929
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, PRKCA, DRD1, GRIA4 4.0458
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 3.9393
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PRKCA, PIK3CB, MET, IGF1R 3.6951
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PRKCA, PIK3CB, MET, IGF1R 3.5904
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, PRKCA, PIK3CB, MMP9 3.5754
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.8677
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, PRKCA, DRD1, GRM1 3.5904
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PRKCA, PIK3CB, ESR1 3.07
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.0438
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PRKCA, PIK3CB, MMP9 3.07
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PRKCA, PIK3CB 3.0571
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PRKCA, PIK3CB 3.2397
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PRKCA, PIK3CB, MET, IGF1R 2.7113
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, PRKCA, DRD1, GRIA4 2.9694
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.2216
Long-term depression_Homo sapiens_hsa04730 GRIA2, PRKCA, GRM1, IGF1R 3.1461
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.6977
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PRKCA, PIK3CB, PTGS2 2.626
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.7261
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, PRKCA, GRM1 3.0438
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.0335
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA, DRD1 3.4561
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 2.95
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PRKCA, PIK3CB 2.5089
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PRKCA, PIK3CB 2.6712
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5089
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, PIK3CB, PTGS2 2.6819
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP2D6, CYP1A2, CYP3A4 3.0031
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.3453
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.3526
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, PRKCA, PIK3CB, IGF1R 2.4362
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8259
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, IGF1R 2.1624
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0031
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, GRM1, IGF1R 2.0733
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.0649
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 1.7929
Influenza A_Homo sapiens_hsa05164 FDPS, PIK3CA, PRKCA, PIK3CB 1.756
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.73
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2343
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2435
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2526
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2519
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.5829
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2635
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, IGF1R 1.7617
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA 1.756
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.3116
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.0751
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.04
Morphine addiction_Homo sapiens_hsa05032 ADORA1, PRKCA, DRD1 1.756
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PRKCA, PIK3CB 2.148
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PRKCA, PIK3CB 1.7368
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 1.9718
Axon guidance_Homo sapiens_hsa04360 MET 0.3444
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.73
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3522
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.0649
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.3576
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3176
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCA, CDC25B 0.4578
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2, PRKCA 1.961
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, PRKCA, GRIA4 1.73
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.0649
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PRKCA, PIK3CB 1.6796
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.4082
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PRKCA, PIK3CB 1.3999
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.3756
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.413
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PRKCA, PIK3CB 1.6866
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.3559
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PRKCA, PIK3CB 1.318
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.3756
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 1.5223
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PRKCA, PIK3CB 1.7055
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1 0.634
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.3039
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, PIK3CB 1.262
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.0696
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB 1.045
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8187
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4316
HTLV-I infection_Homo sapiens_hsa05166 FDPS, PIK3CA, PIK3CB 0.8374
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2, PRKCA 1.7249
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 1.9935
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.1001
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4479
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4479
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.7828
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PRKCA 0.776
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4479
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4479
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 0.8608
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8438
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.815
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.4721
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9485
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 0.959
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.959
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 0.9817
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5072
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5173
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5147
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.0294
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5197
Salivary secretion_Homo sapiens_hsa04970 CHRM3, PRKCA 1.054
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.0949
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.0572
Insulin secretion_Homo sapiens_hsa04911 CHRM3, PRKCA 1.0802
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5394
Shigellosis_Homo sapiens_hsa05131 SRC 0.5393
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.0949
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5393
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.1797
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1219
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1977
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PRKCA, PIK3CB 2.6319
Legionellosis_Homo sapiens_hsa05134 CLK1 0.594
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.594
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2278
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6173
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6173
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6192
Malaria_Homo sapiens_hsa05144 MET 0.624
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.2934
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.318
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.3999
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.4544
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA, ESR1 1.4672
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.494
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6979
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4804
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6979
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.745
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.582
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7828
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.756
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7657
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.7617
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.6792
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.73
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8374
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7918
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6605
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8251
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9458
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8604
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 1.9718
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.983
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.054
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0695


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)