TCM Prescription: Feng Shi Gu Tong Pills



Prescription Description
Prescription IDTCMF3391
Pinyin NameFeng Shi Gu Tong Wan
Chinese Name风湿骨痛丸
English NameFeng Shi Gu Tong Pills
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH296 Radix aconiti 川乌 TCMH296
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1, TYR 11.5407
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, MIF, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC22A1, SLC22A2, SLC22A3, SRC, TNKS, TNKS2, TRPV1, XDH 11.2889
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 11.0826
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SRC, TRPV1, TYR 10.7829
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1, TRPV1 10.6176
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH 9.2004
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH 9.2004
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SRC, TRPV1, TYR 9.06827
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH 8.55304
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PRKCE, PTGS2, RORC, SRC, TYR 8.14171
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, PRKCE, PRKCG, PTGS2, RORC, SRC, TRPV1, TYR 8.1122
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, PRKCD, PRKCE, PTGS2, SRC, TRPV1 7.90546
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.7367
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 7.7367
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.7367
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.53396
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 7.29758
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC 7.04863
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC 6.90068
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SRC, TRPV1 6.81652
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, GLO1, MIF, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.71467
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.67434
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.51214
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.43243
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, POLB, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1 6.43243
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 6.43243
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, KDR, MIF, PIK3CB, PRKCE, PTGS2, SRC, TNKS, TNKS2, TRPV1 6.42843
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TRPV1, TYR 6.37309
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 6.37216
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.37216
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCD, PTGS2, RORC, SRC, TNKS2, TOP2A, TYR 6.34846
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC 6.31453
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.15985
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 6.09758
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.01901
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 5.99424
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, PIK3CA, POLA1, POLB, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SRC, TOP2A, TRPV1 5.99424
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.99424
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS1, PTGS2, SRC, XDH 5.91608
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.81636
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.78206
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC 5.78206
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TNKS, XDH 5.70847
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2, TBXAS1 5.69388
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.6332
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 5.62621
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 5.62483
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.5679
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, F3, FLT3, KDR, MET, MIF, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, XDH 5.55873
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.51639
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2, TBXAS1 5.51639
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 5.4218
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TNKS, XDH 5.37099
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA, PRKCE, SLC22A1 5.35735
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, PRKCD, PRKCE, PTGS2, SRC, TRPV1 5.28162
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.2208
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.21046
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.20617
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SRC 5.17246
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 5.17246
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SRC 5.17246
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, POLB, PPARA, SRC, TYR 5.02946
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.00329
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 4.9672
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TRPV1 4.95486
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 4.86343
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SRC 4.81018
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, POLA1, POLB, PRKCB, PRKCE, SRC, TRPV1 4.81018
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2 4.78251
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, POLB, PRKCD, PRKCE, SRC 4.77716
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SRC 4.75408
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 4.74712
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SRC 4.74712
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SRC 4.70933
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 4.70933
[BP] GO:0032845 None ADORA1, BCL2, MIF, PRKCE, SRC, TNKS, TNKS2, TRPV1 4.60107
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SRC 4.60107
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, HSD11B2, MIF, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TRPV1 4.4981
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.46742
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.39336
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2, TBXAS1 4.37933
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, FLT3, FUT7, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TRPV1 4.36119
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.30875
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 4.30649
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.30649
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 4.30649
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.30649
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, SRC 4.30649
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.26028
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.26028
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGS1, PTGS2, TBXAS1 4.25647
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, MIF, PIK3CB, PIM1, POLA1, PRKCD, SRC, TYR 4.24455
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1, TYR 4.23658
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, ESRRB, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.22503
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS, TOP2A 4.19807
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, MIF, PPARA, PTGS1, PTGS2, TBXAS1 4.10254
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, PRKCD, SRC 4.06857
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.053
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 4.03958
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.01489
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, F3, FLT3, FUT7, GBA2, GLO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.97978
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, SRC 3.97978
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SRC, TNKS2, TRPV1, TYR 3.97978
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TNKS, TNKS2, TRPV1 3.95958
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS 3.95469
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 3.9474
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 3.94665
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.94665
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.89183
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1, TYR 3.87623
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.84223
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CYP19A1, ESR1, F3, FABP4, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 3.82846
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.82742
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, PRKCD, PTGS1, PTGS2, SRC 3.75462
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.74641
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, PRKCG, SRC 3.73738
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, HSD11B2, IGF1R, PPARA, PRKCD, PTGS2, SRC, TRPV1 3.69845
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC, TRPV1 3.679
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.66064
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 3.65529
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, PRKCE, SRC, TRPV1 3.56134
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC 3.5593
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SRC, TRPV1, TYR 3.53337
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, PRKCG, RORC, SRC, TOP2A 3.53337
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 3.49884
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.47822
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 3.45986
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, ESR1, F3, FABP4, KDR, MET, MIF, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2 3.43852
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 3.38192
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, ESRRB, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1 3.36264
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.33499
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SRC, TYR 3.29047
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.29024
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, MIF, POLB, PRKCD, PTGS2 3.27379
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.25793
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.23786
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 3.23786
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.21647
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.16244
[BP] GO:0006855 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.15575
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.11289
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.11289
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MIF, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 3.09853
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.07901
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.07901
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 3.07901
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 3.06153
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CDK6, CYP19A1, ESR1, ESRRA, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC 3.06153
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, PRKCE 3.05144
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.04549
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1 3.0301
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, MIF, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2, TRPV1 2.98469
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, MIF, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TRPV1 2.97104
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 2.97104
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 2.97104
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.95366
[BP] GO:0030335 positive regulation of cell migration BCL2, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.93911
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 2.93554
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.91478
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.87311
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, SRC 2.87118
[BP] GO:0015872 None SLC22A1, SLC22A2, SLC22A3 2.87118
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.87118
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.87118
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.87118
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS, TRPV1, XDH 2.86745
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, MET, MIF, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TNKS, XDH 2.85837
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SRC, TNKS2, TRPV1, XDH 2.85584
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, MIF, PTGS1, PTGS2 2.84932
[BP] GO:2000147 positive regulation of cell motility BCL2, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.83731
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.82818
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 2.82818
[BP] GO:0035408 None PRKCA, PRKCB 2.82818
[BP] GO:0009115 None AOX1, XDH 2.82818
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.82818
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, PPARA, PRKCD, PTGS2, SRC, TRPV1 2.82482
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.82482
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.80223
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.80223
[BP] GO:0001516 None MIF, PTGS1, PTGS2 2.80223
[BP] GO:0046457 None MIF, PTGS1, PTGS2 2.80223
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 2.79587
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 2.77336
[BP] GO:0051272 positive regulation of cellular component movement BCL2, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.77123
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF, PRKCD 2.7533
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SRC, XDH 2.7471
[BP] GO:0031401 positive regulation of protein modification process ADORA1, BCL2, CDC25B, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 2.71798
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.71798
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, TRPV1 2.70829
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC, XDH 2.70829
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.69067
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, IGF1R, PRKCD, PRKCG, SRC, TNKS, TNKS2 2.68537
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, IGF1R, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS, XDH 2.67915
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.6627
[BP] GO:0040017 positive regulation of locomotion BCL2, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.66183
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC 2.64998
[BP] GO:0051937 None SLC22A1, SLC22A2, SLC22A3 2.63746
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, PTGS2, SRC 2.61975
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.61975
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, MIF, MMP9, POLA1, POLB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TOP2A, TRPV1 2.61975
[BP] GO:0043408 regulation of MAPK cascade ADORA1, FLT3, IGF1R, KDR, MIF, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 2.61975
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, IGF1R, KDR, MET, MIF, PIK3CA, PIK3CB, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC 2.61946
[BP] GO:0015893 None CA2, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.61897
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, ESR1, F3, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 2.60761
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 2.59953
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, ESRRB, F3, KDR, MET, MIF, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SRC, TRPV1 2.59953
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, F3, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 2.58202
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.57107
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.57107
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 2.56857
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC 2.56807
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, PIK3CB, PTGS2, TNKS, TNKS2 2.55645
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2 2.53931
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, FLT3, KDR, MIF, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, XDH 2.52969
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, PTGS2, SRC 2.52969
[BP] GO:0050730 None ADORA1, FLT3, MIF, PRKCD, PRKCE, PTPN1, SRC 2.50793
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.50793
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.50793
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 2.49212
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.4703
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.46887
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.4669
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SRC, XDH 2.4669
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SRC 2.46643
[BP] GO:0042752 None ADORA1, PPARA, PRKCG, RORC, TOP2A 2.46643
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SRC, XDH 2.46643
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.46643
[BP] GO:0046110 None AOX1, XDH 2.46643
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46643
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.45894
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.45894
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.45894
[BP] GO:0051172 None APEX1, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, MIF, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.45812
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PRKCB, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 2.41496
[BP] GO:0010676 None ESRRB, PPARA, PRKCE, SRC 2.40077
[BP] GO:0050994 None ADORA1, PPARA, PRKCD, PRKCE 2.40077
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.39424
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, MIF, PIM1, PRKCA, PRKCE, PTGS2, SRC, TNKS, TOP2A 2.39424
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HSD11B2, PTGS2, SRC, TRPV1, TYR 2.38632
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.38326
[BP] GO:0031399 regulation of protein modification process ADORA1, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 2.37982
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.37621
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, PRKCD, PTGS2, TRPV1, XDH 2.37319
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 2.33905
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, IGF1R, MIF, PIK3CB, PRKCD, PTPN1, SRC 2.33905
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, ESRRB, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 2.33608
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.33321
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 2.31775
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TNKS 2.31775
[BP] GO:0030155 regulation of cell adhesion BCL2, CDK6, CYP1B1, KDR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SRC 2.3
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2 2.2999
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2 2.28859
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.28429
[BP] GO:0015844 None SLC22A1, SLC22A2, SLC22A3 2.28429
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.28429
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PPARA, PRKCD, PTGS2, RORC, SRC, TNKS, TNKS2, TOP2A, TRPV1 2.27681
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, KDR, MET, MIF, MMP2, MMP9, PRKCD, PTGS2, RORC, SRC, TOP2A 2.26711
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SRC, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.25965
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.24641
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PTGS2, SRC, TOP2A 2.24485
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, ESR1, FLT3, IGF1R, MMP2, PRKCD, PRKCE, PTGS2, SRC, TRPV1 2.23695
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.2334
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.2334
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TNKS 2.2295
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.22594
[BP] GO:0015874 None SLC22A1, SLC22A2 2.22594
[BP] GO:1901374 None SLC22A1, SLC22A2 2.22594
[BP] GO:0070213 None TNKS, TNKS2 2.22594
[BP] GO:0006145 None AOX1, XDH 2.22594
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22594
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, MIF 2.22152
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.20774
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.19007
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.19007
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MIF, MMP12, MMP9, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.1886
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, CDK6, KDR, PIK3CB, PRKCE, SRC 2.16633
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, MET, PIK3CA, TRPV1 2.15669
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.14058
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, MIF, MMP12, PRKCD, PRKCE, PTGS2, SRC, TRPV1 2.14011
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, MIF, PRKCA, PRKCE, SRC 2.12964
[BP] GO:0016477 cell migration AXL, CYP1B1, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC 2.1263
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.11719
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, PRKCE, PTGS2 2.11719
[BP] GO:0010675 None ESRRB, PPARA, PRKCE, RORC, SRC 2.11719
[BP] GO:0032103 positive regulation of response to external stimulus F3, FABP4, KDR, MET, MIF, PRKCA, PTGS2 2.10556
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUT7, MIF, MMP9, PRKCB, PRKCD, PRKCE, RORC, TRPV1 2.1031
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, MIF 2.09829
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.09565
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP2, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.0761
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PTGS2, SRC 2.074
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, MIF, MMP12, PRKCE, SRC, TRPV1 2.0565
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, ESR1, F3, FLT3, MIF, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SRC, TNKS, XDH 2.0565
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.0565
[BP] GO:0006693 None MIF, PTGS1, PTGS2 2.0565
[BP] GO:0006692 None MIF, PTGS1, PTGS2 2.0565
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, FLT3, FUT7, IGF1R, KDR, MET, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.0525
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, FLT3, FUT7, IGF1R, KDR, MET, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.0525
[BP] GO:0043696 None CDK6, ESRRB 2.04975
[BP] GO:0043697 None CDK6, ESRRB 2.04975
[BP] GO:0098501 polynucleotide dephosphorylation APEX1, POLB 2.04975
[BP] GO:0010641 None F3, SRC 2.04975
[BP] GO:0046618 None SLC47A1, SLC47A2 2.04975
[BP] GO:0045913 None ESRRB, PPARA, PRKCE, SRC 2.03756
[BP] GO:0051052 regulation of DNA metabolic process AURKB, IGF1R, PIK3CA, PRKCD, PRKCG, SRC, TNKS, TNKS2 2.02579
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.01894
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.01627
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.00163
[BP] GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.00053
[BP] GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.00053
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR 3.30265
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, F3, FLT3, GBA2, GLO1, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TRPV1 3.2227
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, NQO2, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC47A1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.92872
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MIF, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.77608
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CYP19A1, FLT3, GBA2, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 2.71798
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, CA4, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TNKS2, TYR 2.41424
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, TBXAS1, TNKS, TYR, XDH 16.3299
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 14.1018
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 12.5373
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, TNKS 9.80872
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.74129
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 9.34115
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 9.08128
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.7367
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.28985
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 6.09113
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.98867
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB 5.83067
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.78677
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.64222
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 5.58873
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.4218
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.35735
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.95374
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.95374
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.95374
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.92067
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.86343
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.75408
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB, PRKCD 4.74712
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.72291
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 4.60107
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.5471
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1, TYR 4.37933
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.30875
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.30649
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 4.17277
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 4.17228
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.73628
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.54237
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.49884
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, TRPV1 3.41368
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.3485
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.29047
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 3.23786
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.2227
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.21242
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 3.2061
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.2061
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.19355
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TOP2A, TRPV1, XDH 3.12985
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 3.12124
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 3.0891
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TOP2A, TRPV1, XDH 3.07901
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.03489
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.03209
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.97104
[MF] GO:0019899 enzyme binding AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, ESR1, ESR2, ESRRB, F3, MET, MIF, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS2, TOP2A 2.95152
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.87118
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CSNK2A1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 2.86877
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.82818
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.82818
[MF] GO:0003845 None HSD11B1, HSD11B2 2.82818
[MF] GO:0035403 None PRKCA, PRKCB 2.82818
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.81443
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP9, NQO2, PTGS2, SLC22A1, TOP2A, TRPV1, TYR, XDH 2.77336
[MF] GO:0043168 anion binding AOX1, AURKB, AXL, CDK6, CSNK2A1, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 2.7471
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.61975
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.59027
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.53907
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, F3, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC 2.53554
[MF] GO:0015238 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.52627
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.50793
[MF] GO:0015307 None SLC47A1, SLC47A2 2.46643
[MF] GO:1901375 None SLC22A1, SLC22A2 2.46643
[MF] GO:0005333 None SLC22A1, SLC22A2 2.46643
[MF] GO:0005277 None SLC22A1, SLC22A2 2.46643
[MF] GO:0008513 None SLC22A1, SLC22A2 2.46643
[MF] GO:0004699 None PRKCD, PRKCE 2.46643
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.29159
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.27488
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.22594
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.21104
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.1664
[MF] GO:0015101 None SLC22A1, SLC22A2, SLC22A3 2.14058
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.13649
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.12964
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04975


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3 9.2567
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.0501
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PIK3CA, PRKCB, SRC, MMP2, KDR, PRKCA, PIK3CB, MMP9, MET, ESR1, IGF1R 9.0501
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.474
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 8.5799
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, IGF1R, CDK6, PIK3CA, BCL2, MET 8.1422
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, PRKCA, PIK3CB, TRPV1 8.4814
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, CDC25B, CDK6, PIK3CA, BCL2, PIM1, CYP1B1, MET 8.5249
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.6832
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 7.7854
Hepatitis B_Homo sapiens_hsa05161 PRKCG, CDK6, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 7.1561
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, ESR2 7.1561
Glioma_Homo sapiens_hsa05214 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB, IGF1R 7.1561
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB 7.1561
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 7.1561
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, MET, IGF1R 5.9454
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 6.1402
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.8156
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB 6.1402
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB 5.7392
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB, IGF1R 5.9045
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.1402
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PIK3CA, PRKCB, PRKCA, PIK3CB 7.0407
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, PRKCE, PRKCD, PIK3CB, PPARA 5.7747
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 5.5924
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 5.5924
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PIK3CA, PRKCB, KDR, PRKCA, PIK3CB, MET, IGF1R 4.7844
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2 4.7862
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB 5.1429
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 5.1429
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, PRKCB, ALOX5, PRKCA, PTGS2, PTGS1 4.5743
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.6951
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.3593
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.3424
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 3.6828
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA 3.9165
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.2965
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 4.0244
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.0903
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.7926
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.7605
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.4051
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.4302
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.2322
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.9759
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.5707
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.4924
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PRKCE, ADORA1, PIK3CB 2.8996
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.3406
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 3.0777
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.2137
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.9642
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, PIK3CA, SRC, PIK3CB 2.5571
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.8533
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.7147
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.1332
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.838
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0584
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2, PTGS1 3.4458
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PRKCE, PRKCD, PIK3CB 3.8271
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.9759
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.2287
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 2.934
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.8114
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, PRKCA 2.9759
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.6803
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3075
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, PRKCA, PTGS2 2.8013
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.9048
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.3686
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.5727
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.5571
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0901
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.8655
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2871
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3119
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.3423
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, CSNK2A1, PRKCB, PRKCA 2.3423
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 2.2906
Axon guidance_Homo sapiens_hsa04360 MET 0.4014
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4096
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB 2.0559
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0219
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.8781
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4618
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4729
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7542
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4921
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7493
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1 0.9307
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9682
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5589
cAMP signaling pathway_Homo sapiens_hsa04024 PIK3CA, ADORA1, PIK3CB, PPARA 1.8962
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, PIK3CB 0.9884
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.1578
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5091
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, PRKCB, PRKCA, CDC25B 1.5772
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5119
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.5772
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.5791
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5105
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.626
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9307
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, PRKCB, PRKCA 1.3407
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.5077
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.626
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.6951
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9682
Peroxisome_Homo sapiens_hsa04146 XDH 0.5306
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA 1.6533
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PRKCA, PIK3CB 1.5578
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.7894
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5462
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0752
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.083
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.9851
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.083
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 1.9813
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5887
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 2.0422
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5914
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 2.0888
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6119
Shigellosis_Homo sapiens_hsa05131 SRC 0.6114
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.3512
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 2.2658
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6114
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.2658
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.3683
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.3512
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.3342
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.3512
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.3969
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA 2.3423
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.3543
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.2906
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6676
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.3417
Bile secretion_Homo sapiens_hsa04976 CA2, SLC22A1 1.3603
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3603
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6942
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6942
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.376
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3842
Malaria_Homo sapiens_hsa05144 MET 0.7042
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7095
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.7149
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7206
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4913
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.5772
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.7673
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 3.0119
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7675
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 3.0119
DNA replication_Homo sapiens_hsa03030 POLA1 0.8069
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8649
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8861
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8861
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9215
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8752
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9813
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.909
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.9104
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9322
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8496
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1789
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.0752
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.0554
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1445
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4776
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3098


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)