TCM Prescription: Fu Fang Zi Shen Infusion



Prescription Description
Prescription IDTCMF3387
Pinyin NameFu Fang Zi Shen Chong Ji
Chinese Name复方紫参冲剂
English NameFu Fang Zi Shen Infusion
Function Description鼓胀
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1935 Salvia chinensis 石见穿 TCMH1935 ITSAL854-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH178 Carapax trionycis 鳖甲 TCMH178
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5216
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, FUT7, HSD17B3, PIM1, PPARA, PTGES, TYR, XDH 11.5216
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6993
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, FABP3, FABP4, FUT7, HSD17B2, HSD17B3, MET, PPARA, PTGES 8.34057
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TYR, XDH 8.31638
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, ESR1, HSD17B2, HSD17B3 8.12937
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.79375
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, CDC25B, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MMP12, MMP2, MMP9, PIM1, PTGES, RELA, SLC6A4, SRC, TERT, XDH 7.3921
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 7.3921
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, TYR, XDH 7.25531
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES 7.11645
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, APP, AR, AXL, CA2, CA9, CES1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 7.03803
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 7.02866
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES 6.90197
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SLC6A4, SRC, TYR 6.46235
[BP] GO:0033993 response to lipid AR, AXL, CA2, CA9, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PTGES, RELA, RORC, SLC6A4, SRC, TYR 6.37954
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA, PTGES 6.33553
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES 6.20844
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGES, RELA, SRC, TERT 6.20844
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, APP, AR, AXL, CA2, CA7, CYP19A1, CYP1B1, F3, FLT3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SRC, TERT, XDH 6.05154
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, APP, AR, AXL, CA2, CA7, CYP19A1, CYP1B1, F3, FLT3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SRC, TERT, XDH 6.02686
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, APP, AR, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PPARA, PTGES, RELA, RORC, SLC6A4, SRC, TYR 5.85267
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HSD17B3, KDR, MAP2K1, PPARA, RELA, SRC, TYR 5.61602
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES 5.6047
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, PTGES, RELA, RORC, SLC6A4, SRC, TYR 5.57613
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, XDH 5.40272
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, RORC 5.40272
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B2, HSD17B3, KCNH2, KDR, MAOA, MET, PPARA, SLC6A2, SLC6A4, SRC, TERT, XDH 5.39986
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HSD17B2, HSD17B3, MAOA, TYR, XDH 5.1674
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 5.00812
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.88852
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.87223
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, RELA, RORC, SLC6A4, SRC, TERT 4.84595
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT, XDH 4.81939
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, FABP4, FUT7, MET, PPARA, PTGES 4.78063
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, APP, AR, AXL, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 4.71043
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PTPN1, RELA, SRC, TERT, XDH 4.70255
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, CA2, CA9, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, PPARA, RELA, SLC6A4, SRC 4.68033
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, FABP4, FUT7, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.6708
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CA6, CA9, CES1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 4.66493
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES 4.59231
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SLC6A2, SLC6A4, SRC, TYR 4.58705
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, AR, CA2, CA9, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PPARA, RELA, SLC6A4, SRC 4.54583
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, XDH 4.52833
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2, HSD17B3 4.39439
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA, PTGES 4.36711
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.32082
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SLC6A4, SRC, TERT, XDH 4.29019
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MMP2, MMP9, PTPN1, RELA, RORC, SLC6A4, SRC, TERT 4.27513
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SLC6A4, SRC, TERT, XDH 4.18054
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MMP9, PIM1, PTPN1, RELA, SRC, TERT, XDH 4.17994
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, APP, AR, AXL, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SRC, TERT, XDH 4.14395
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B2, HSD17B3 4.1369
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, APP, CES1, CYP19A1, CYP1A1, CYP1B1, HSD17B3, MAOA, TYR 4.13316
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2, HSD17B3 4.02603
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA9, CACNA1C, CDC25B, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, HSD17B3, KDR, MAP2K1, MET, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SLC6A4, SRC, TERT, TYR 3.88417
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, CDC25B, ESR1, F3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, RELA, TERT 3.86661
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.85325
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CYP19A1, ESR1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP12, MMP2, PPARA, PTPN1, RELA, SRC, TERT, XDH 3.74144
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APP, AR, AXL, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, F3, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 3.73346
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, APP, AR, AXL, CA2, CACNA1C, CYP1B1, ESR1, ESRRA, ESRRB, F3, HCAR2, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, RELA, SLC6A4, SRC, TERT, XDH 3.6106
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, XDH 3.58053
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, APP, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, RELA, RORC, SLC6A4, SRC 3.54828
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT 3.51501
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, APP, AR, AXL, CYP1B1, ESRRA, F3, FABP4, FLT3, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PTPN1, RELA, SRC, TERT, XDH 3.51501
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, APP, AR, AXL, CA2, CYP1B1, ESRRB, F3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, RELA, SRC, TERT 3.47086
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.446
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.446
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, AR, AURKB, AXL, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TYR, XDH 3.43184
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.39879
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PTGES, TYR 3.34959
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 3.34697
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SLC6A4, SRC 3.30368
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, RELA, SRC, TERT 3.30368
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 3.27569
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, RELA, RORC, SLC6A4, SRC 3.26174
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, MAOA 3.23891
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, AR, AURKB, AXL, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TYR, XDH 3.21714
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, CACNA1C, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.19287
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, APP, AR, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, XDH 3.19061
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.17023
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2A6, CYP2C19, MAOA 3.17023
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, APP, AR, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, XDH 3.1577
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, RORC, SLC6A4, SRC 3.05451
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.04505
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR, XDH 3.03506
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APP, AXL, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, SRC, TERT 3.0224
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.01369
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, APP, AR, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, XDH 3.00392
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, SRC 2.99084
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 2.96502
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KCNH2, KDR, MAP2K1, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, XDH 2.96165
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, APP, AR, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, XDH 2.95627
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PTGES, TYR 2.95627
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.92339
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.91385
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, APP, AR, CDC25B, ESRRB, FABP3, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.90059
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, APP, AR, CDC25B, ESRRB, FABP3, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.90059
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PTGES, TYR 2.88823
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.83263
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.83263
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, APP, AR, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.82881
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, APP, AR, AURKB, CDC25B, ESR1, ESR2, F3, FLT3, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, XDH 2.82751
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.82191
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, APP, AR, CDC25B, ESRRB, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.79955
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.79955
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, MAP3K7, PIM1, RELA 2.79955
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, IGF1R, KDR, MMP9, PIM1, PTPN1, RELA, SRC, TERT 2.79955
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, AR, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, RELA, SLC6A4, SRC, TERT, XDH 2.78913
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, AR, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, RELA, SLC6A4, SRC, TERT, XDH 2.77808
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KCNH2, KDR, RELA, SLC6A2, SLC6A4, SRC 2.75709
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HSD17B3, KDR, MAP2K1, MMP9, PIM1, PPARA, RELA, RORC, SRC, TYR 2.74998
[BP] GO:0009115 None AOX1, XDH 2.74024
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, FABP3, KCNH2, PPARA, SLC6A2, SLC6A4 2.73241
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CES1, CYP1A1, CYP1B1, KDR, RELA, SLC6A4, SRC 2.7087
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.656
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.64654
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES, TERT 2.57526
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, APP, AR, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 2.57222
[BP] GO:0022414 reproductive process AKR1B1, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, HSD17B3, MAP2K1, MMP2, MMP9, SLC6A4, SRC 2.53743
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, MAP2K1, MET, PIM1, SRC, TYR 2.53743
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, HCAR2, KCNH2, MAP2K1, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 2.51504
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.49509
[BP] GO:0070920 None ESR1, MAP2K1, TERT 2.49509
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A4, SRC, TERT, XDH 2.46609
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 2.46609
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.44639
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.42602
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, IGF1R, MAP2K1, MAP3K7, PTPN1, SRC 2.41371
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, APP, AR, CDC25B, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.41099
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, ESR1, FLT3, IGF1R, MMP2, RELA, SLC6A4, SRC 2.3953
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, APP, AR, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 2.37659
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.34098
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CYP19A1, HCAR2, KCNH2, MMP12, SLC6A4, SRC, TERT 2.34098
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, APP, AR, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 2.34098
[BP] GO:0046110 None AOX1, XDH 2.34098
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.34098
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.33466
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.33322
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.31364
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, MAP2K1, PTGES, SLC6A4, TERT, XDH 2.30989
[BP] GO:0071396 cellular response to lipid AR, AXL, ESR1, FLT3, RELA, RORC, SLC6A4, SRC 2.30798
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.30798
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA, SRC 2.29088
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, MAP2K1, MAP3K7, PTPN1, SRC 2.27243
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.25878
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.25032
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, CACNA1C, HCAR2, KDR, SRC 2.23928
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.22407
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, MMP2, PPARA, RELA, SLC6A4, SRC, TERT, TYR 2.2057
[BP] GO:0003006 developmental process involved in reproduction AR, AXL, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, MAP2K1, SRC 2.2057
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SRC, TERT 2.20437
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.16201
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.15944
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, AR, CYP19A1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, RELA, SRC, TERT, XDH 2.15944
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.15944
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.15944
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.15944
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SRC, TERT 2.14151
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.14151
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B2, HSD17B3 2.14151
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KCNH2, KDR, RELA, SRC 2.13686
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AXL, CA1, CA2, CACNA1C, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC 2.13389
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.13301
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.1279
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.1279
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1279
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.1279
[BP] GO:0006145 None AOX1, XDH 2.1279
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.1279
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.1279
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, FABP3, FLT3, IGF1R, MMP2, PPARA, RELA, SLC6A4, SRC, TYR 2.08252
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.08252
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.08252
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.08252
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.07029
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.07029
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD17B2, HSD17B3 2.05616
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PTPN1, RELA, SRC 2.02336
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, RELA, SRC, TERT, XDH 2.02336
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.0137
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC 2.00667
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MAP2K1, MET, MMP12, PPARA, PTPN1, RELA, RORC, SRC, TERT 2.00237
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.28193
[CC] GO:0044432 endoplasmic reticulum part APP, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FLT3, HSD17B2, HSD17B3, PTGES, PTPN1 2.25802
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, AR, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSD17B3, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PTGES, PTPN1, RELA, SLC6A4, SRC, TERT, TYR, XDH 2.20522
[CC] GO:0005783 None ADORA1, APP, CA4, CES1, CES2, CYP19A1, FLT3, HSD17B3, KDR, MAP2K1, PTPN1, XDH 1.93815
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, ESR1, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT 1.85196
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 19.3889
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.1916
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6993
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR, XDH 10.6384
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, F3, FLT3, FUT7, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGES, PTPN1, SRC, TERT, TYR, XDH 9.71733
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.47762
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 8.92659
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 8.08606
[MF] GO:0046872 metal ion binding ALOX5, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 7.74445
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, XDH 6.57002
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.4627
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.44713
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.44713
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HSD17B2, HSD17B3, MAOA, TYR, XDH 6.33553
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.12736
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.98164
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TYR 5.97131
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19 5.20226
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.10555
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, SRC 5.05225
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, RORC, SHBG 4.95725
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, SRC 4.84595
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TYR 4.53302
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19 4.36534
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGES, SRC, XDH 4.34057
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 3.86012
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SLC6A4, SRC 3.6936
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 3.50792
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PPARA, RORC 3.40919
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SLC6A4, SRC 3.3555
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 3.27569
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.22921
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.11571
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, PPARA, RORC, SHBG 3.0331
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 2.91385
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, SLC6A4, SRC 2.88327
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B2, HSD17B3, XDH 2.82191
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.82191
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 2.77808
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.74024
[MF] GO:0008389 None CYP2A13, CYP2A6 2.74024
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MAP3K7, MET, MMP9, RELA, SLC6A4, TERT, TYR, XDH 2.7087
[MF] GO:0004672 protein kinase activity AURKB, AXL, FLT3, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.53825
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.42602
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.42602
[MF] GO:0005330 None SLC6A2, SLC6A4 2.34098
[MF] GO:0047374 None CES1, CES2 2.34098
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.25784
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, ESR1, ESR2, ESRRB, F3, KCNH2, MET, PPARA, PTPN1, RELA, SLC6A4, SRC 2.15944
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.1279
[MF] GO:0032795 None ADORA1, ADRA2A 2.1279
[MF] GO:0005497 None AR, SHBG 2.1279


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.325
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 6.3428
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 5.9136
Metabolic pathways_Homo sapiens_hsa01100 MAOA, HSD17B3, AKR1B1, TYR, CYP2C19, CYP19A1, CYP2A6, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, PTGES, CES1 5.3028
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, CACNA1C, CYP2C19, SLC6A4 5.3459
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 5.6423
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 5.0218
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.1101
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, ESR1, ESR2 4.6882
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP2C19 5.086
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, FLT3, MMP1, MMP2, MMP9, MET, RELA, IGF1R 3.9694
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, ESR1, ESR2, RELA 4.1476
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1, CYP2C19 4.2011
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.1476
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MAP3K7, MET, IGF1R 4.1476
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, MAP2K1, ADORA1, CACNA1C, PPARA, RELA 3.1913
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.3354
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.6819
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.1563
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, RELA, IGF1R 2.7036
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C, ADRA2A 2.6944
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.6944
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3, RELA 2.5632
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0759
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIM1, CYP1B1, MMP9, MET, CDC25B 2.4517
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.5632
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.4517
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, MET, IGF1R 2.394
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KDR, MET, IGF1R 2.3361
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KDR, MET, RELA, IGF1R 2.2201
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, ADORA1, RELA 2.3391
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SRC, MMP9, RELA 2.1138
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 2.0773
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.7036
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.2043
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.2215
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET 2.1138
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, IGF1R 2.0773
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.7338
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, KDR, MET, RELA, IGF1R 1.6445
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.7036
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.1138
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, CYP2C19, PTGES 2.1958
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, RELA, IGF1R 1.6923
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.6751
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, CACNA1C 1.6445
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.6893
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA, RELA 1.6499
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4284
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC, ESR1 1.5875
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, MAP3K7, RELA 1.5875
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.5461
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.4706
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, ESRRB, IGF1R 1.4214
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C 1.3187
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.2231
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9066
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, ADRA2A 0.8726
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, RELA 0.9066
Apoptosis_Homo sapiens_hsa04210 MAP2K1, RELA 0.8268
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9066
Measles_Homo sapiens_hsa05162 MAP3K7, RELA 0.8395
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 0.8517
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, IGF1R 0.8864
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 1.0228
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.8277
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 0.8517
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.8658
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.9066
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3329
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C 0.3284
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 1.108
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.0661
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.8
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7828
Epstein-Barr virus infection_Homo sapiens_hsa05169 MAP3K7, RELA 0.6562
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA 0.7212
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.7165
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.7165
Glioma_Homo sapiens_hsa05214 MAP2K1, IGF1R 1.2788
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3441
NF-kappa B signaling pathway_Homo sapiens_hsa04064 MAP3K7, RELA 1.0695
Herpes simplex infection_Homo sapiens_hsa05168 MAP3K7, RELA 0.7005
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.7464
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 CACNA1C 0.3866
HTLV-I infection_Homo sapiens_hsa05166 TERT, RELA 0.5441
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.108
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.6509
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC 0.6321
Tight junction_Homo sapiens_hsa04530 SRC 0.4
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.2308
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1 0.3932
Wnt signaling pathway_Homo sapiens_hsa04310 MAP3K7 0.3953
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.3074
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, RELA 1.2308
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 1.108
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.4074
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.2788
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.2788
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4314
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.086
Axon guidance_Homo sapiens_hsa04360 MET 0.4257
Platelet activation_Homo sapiens_hsa04611 SRC 0.4345
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, RELA 1.2788
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1883
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.2482
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.2788
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.2308
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.2724
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.2788
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4558
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3363
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.486
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2788
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4939
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.4939
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4939
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2482
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.5024
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4942
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4989
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.4939
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5075
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5088
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5114
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.5088
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5217
Salmonella infection_Homo sapiens_hsa05132 RELA 0.5171
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5171
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.4284
Small cell lung cancer_Homo sapiens_hsa05222 RELA 0.5171
Peroxisome_Homo sapiens_hsa04146 XDH 0.5217
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.522
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.4362
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2, MAOA 1.4239
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5302
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5217
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5284
Pertussis_Homo sapiens_hsa05133 RELA 0.542
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5441
Bile secretion_Homo sapiens_hsa04976 CA2 0.5505
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.564
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5441
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.581
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5666
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.581
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1 0.5869
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7338
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1 0.6234
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.6426
Legionellosis_Homo sapiens_hsa05134 RELA 0.6273
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.7438
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6426
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6923
Malaria_Homo sapiens_hsa05144 MET 0.6562
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6574
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6623
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6853
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9237
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7486
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7165
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.7165
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8022
Histidine metabolism_Homo sapiens_hsa00340 ALDH2, MAOA 1.8969
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8236
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7905
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.7905
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8022
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8268
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7962
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8236
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8236
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9462
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2788


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)