Prescription ID | TCMF3361 |
Pinyin Name | Gu Han Yang Sheng Ke Li |
Chinese Name | 古汉养生颗粒 |
English Name | Gu Han Yang Sheng Granules |
Function Description | 眩晕, 心悸, 耳鸣, 不寐, 健忘, 阳痿, 遗精 |
Indications | Involuntary ejaculation disorder, Impotence disorder, Tinnitus disorder, Vertigo disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Tinnitus, Palpitations, Dizziness, Sexual dysfunction |
Disease ICD-11 Category |
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1)
]; SB0B [Impotence disorder (TM1), 阳痿 (TM1) ]; SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ]; SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ]; SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ]; SD84 [Insomnia disorder (TM1), 不寐 (TM1) ]; 7A0Z [Insomnia disorders, unspecified, 失眠障碍,未特指的 ]; MC41 [Tinnitus, 耳鸣 ]; MC81.2 [Palpitations, 心悸 ]; MB48 [Dizziness and giddiness, 头晕和眩晕 ]; HA0Z [Sexual dysfunctions, unspecified, 性功能障碍,未特指的 ]; |
Human Tissues Associated with Indication | Heart, Brain, Kidney |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH1721 | Panax ginseng | 人参 | TCMH1721 | GBVE1679-11 |
TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
TCMH1133 | Rosa laevigata | 金樱子 | TCMH1133 | ITSAJ4477-14 |
TCMH1186 | Lycium chinense | 枸杞子 | TCMH1186 | ITSAO4545-14 |
TCMH1597 | Ligustrum lucidum | 女贞子 | TCMH1597 | ITSAM2109-14 |
TCMH2149 | Cuscuta australis | 菟丝子 | TCMH2149 | ITSAP4209-14 |
TCMH2507 | Epimedium brevicornum | 淫羊藿 | TCMH2507 | AY362429 |
TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
TCMH1430 | Hordeum vulgare | 麦芽 | TCMH1430 | ITSAI3101-14 |
TCMH967 | Polygonatum sibiricum | 黄精 | TCMH967 | ITSAH4762-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
TCMT164 | PTGS1 | Cyclooxygenase-1 | Oxidoreductase | P23219 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT189 | DUSP3 | Dual specificity protein phosphatase 3 | Hydrolase | P51452 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT197 | PDE4D | Phosphodiesterase 4D | Hydrolase | Q08499 |
TCMT209 | HSD11B2 | 11-beta-hydroxysteroid dehydrogenase 2 | Oxidoreductase | P80365 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
TCMT231 | GBA2 | Beta-glucosidase | Hydrolase | Q9HCG7 |
TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT249 | CDK6 | Cyclin-dependent kinase 6 | Kinase | Q00534 |
TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT290 | CHRM5 | Muscarinic acetylcholine receptor M5 | GPCR | P08912 |
TCMT291 | CHRM3 | Muscarinic acetylcholine receptor M3 | GPCR | P20309 |
TCMT292 | CHRM1 | Muscarinic acetylcholine receptor M1 | GPCR | P11229 |
TCMT293 | CHRM2 | Muscarinic acetylcholine receptor M2 | GPCR | P08172 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT30 | PTGS2 | Cyclooxygenase-2 | Oxidoreductase | P35354 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT315 | HTR6 | Serotonin 6 (5-HT6) receptor | GPCR | P50406 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT329 | NQO2 | Quinone reductase 2 | Oxidoreductase | P16083 |
TCMT335 | MPO | Myeloperoxidase | Oxidoreductase | P05164 |
TCMT336 | IDO1 | Indoleamine 2,3-dioxygenase | Oxidoreductase | P14902 |
TCMT34 | CYP2D6 | Cytochrome P450 2D6 | Oxidoreductase | P10635 |
TCMT344 | AOX1 | Aldehyde oxidase | Oxidoreductase | Q06278 |
TCMT354 | AURKA | Serine/threonine-protein kinase Aurora-A | Kinase | O14965 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT377 | INSR | Insulin receptor | Kinase | P06213 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT418 | EPHB4 | Ephrin type-B receptor 4 | Kinase | P54760 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT423 | EGFR | Epidermal growth factor receptor erbB1 | Kinase | P00533 |
TCMT436 | NUAK1 | NUAK family SNF1-like kinase 1 | Kinase | O60285 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
TCMT457 | FLT4 | Vascular endothelial growth factor receptor 3 | Kinase | P35916 |
TCMT46 | F3 | Coagulation factor III | Unclassified | P13726 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT47 | BCL2 | Apoptosis regulator Bcl-2 | Ion channel | P10415 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT502 | TEK | Tyrosine-protein kinase TIE-2 | Kinase | Q02763 |
TCMT506 | PTK2B | Protein tyrosine kinase 2 beta | Kinase | Q14289 |
TCMT508 | SYK | Tyrosine-protein kinase SYK | Kinase | P43405 |
TCMT536 | PDGFRB | Platelet-derived growth factor receptor beta | Kinase | P09619 |
TCMT560 | F10 | Coagulation factor X | Unclassified | P00742 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT591 | ESRRA | Estrogen-related receptor alpha | Nuclear receptor | P11474 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT626 | BRAF | Serine/threonine-protein kinase B-raf | Kinase | P15056 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT698 | PDE4B | Phosphodiesterase 4B | Hydrolase | Q07343 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT721 | HSPA1A | Heat shock 70 kDa protein 1 | Unclassified | P0DMV8 |
TCMT729 | PIK3CA | PI3-kinase p110-alpha subunit | Transferase | P42336 |
TCMT730 | PIK3CB | PI3-kinase p110-beta subunit | Transferase | P42338 |
TCMT739 | GPR35 | G-protein coupled receptor 35 | GPCR | Q9HC97 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT753 | SMAD3 | Mothers against decapentaplegic homolog 3 | Unclassified | P84022 |
TCMT755 | PLK4 | Serine/threonine-protein kinase PLK4 | Kinase | O00444 |
TCMT756 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Kinase | P41279 |
TCMT771 | ATR | Serine-protein kinase ATR | Kinase | Q13535 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT848 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | Kinase | O75460 |
TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
TCMT910 | ESRRB | Estrogen-related receptor beta | Nuclear receptor | O95718 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1179 | Escherichia coli ATCC 8739 |
TCMT1180 | Human herpesvirus 2 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1182 | Streptococcus sanguinis |
TCMT1186 | Plasmodium yoelii yoelii |
TCMT1189 | Pseudomonas fluorescens |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1191 | Bacillus megaterium |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1217 | Bacillus anthracis |
TCMT1218 | Staphylococcus aureus |
TCMT1221 | Human herpesvirus 4 |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1224 | Proteus mirabilis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1227 | Streptococcus |
TCMT1229 | Enterococcus faecalis |
TCMT1231 | Human herpesvirus 1 strain KOS |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1234 | Bacillus coagulans |
TCMT1235 | Clostridium sporogenes |
TCMT1236 | Mycobacterium bovis |
TCMT1237 | Mycobacterium kansasii |
TCMT1238 | Mycobacterium xenopi |
TCMT1239 | Mycobacterium marinum |
TCMT1243 | Aspergillus flavus |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1249 | Dengue virus 2 |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1260 | Streptococcus agalactiae |
TCMT1284 | Penicillium expansum |
TCMT1286 | Bacillus cereus |
TCMT1289 | Shigella dysenteriae |
TCMT1292 | Japanese encephalitis virus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1319 | Corynebacterium xerosis |
TCMT1322 | Streptococcus mitis |
TCMT1323 | Corynebacterium pseudodiphtheriticum |
TCMT1324 | Corynebacterium diphtheriae |
TCMT1336 | Yellow fever virus |
TCMT1337 | Dengue virus type 4 |
TCMT1338 | Rift Valley fever virus |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1353 | Plasmodium yoelii |
TCMT1361 | Neisseria meningitidis |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1390 | Human herpesvirus 2 strain G |
TCMT1393 | Vibrio sp. |
TCMT1410 | Listeria monocytogenes |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1457 | Leishmania major |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, MPO, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR | 11.3344 |
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 11.1917 |
[BP] GO:0010033 | response to organic substance | AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MPO, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR | 10.5076 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 10.5076 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH | 10.5076 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 10.5076 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 10.5076 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH | 9.85938 |
[BP] GO:0033993 | response to lipid | ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, MPO, PTGS2, RORC, SRC, TYR | 9.85938 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 9.08397 |
[BP] GO:0042221 | response to chemical | AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, MPO, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR | 8.8885 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 8.78344 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH | 8.71004 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, GBA2, HSPA1A, IDO1, MPO, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH | 8.69886 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TYR | 8.54854 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR6, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 8.4522 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 8.45046 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 8.45046 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR6, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 8.43226 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 8.39626 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, IDO1, IGF1R, INSR, MET, MMP1, MMP2, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TYR | 8.20695 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 8.20695 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK | 7.8408 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 7.8408 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR6, IDO1, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 7.76144 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK | 7.72659 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR | 7.6891 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 7.62003 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, NQO2, PTGS1, PTGS2, TYR, XDH | 7.52007 |
[BP] GO:0014070 | response to organic cyclic compound | ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, RORC, SRC, TEK, TYR | 7.34533 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 7.30286 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR | 7.29455 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 7.17505 |
[BP] GO:0009725 | response to hormone | AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, PPARA, PTGS2, SRC, TEK | 7.17505 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MMP9, MPO, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK | 7.10272 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH | 7.04869 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR | 7.00327 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, APP, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 6.82728 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MPO, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH | 6.69582 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.66639 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK | 6.59965 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 6.59965 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH | 6.41985 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, FABP3, FABP4, FUT7, GBA2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 6.32908 |
[BP] GO:0007197 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.32908 |
[BP] GO:0048583 | regulation of response to stimulus | ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 6.29768 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 6.24676 |
[BP] GO:0019369 | arachidonic acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 6.11617 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 6.08754 |
[BP] GO:0030335 | positive regulation of cell migration | APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 6.03781 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC | 6.03001 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, MPO, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TYR | 5.97957 |
[BP] GO:0007207 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 5.92026 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 5.89643 |
[BP] GO:2000147 | positive regulation of cell motility | APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 5.87786 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC | 5.83569 |
[BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS | 5.82311 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 5.77423 |
[BP] GO:0051272 | positive regulation of cellular component movement | APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 5.74646 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH | 5.7311 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7, CA9 | 5.7311 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TNKS, XDH | 5.7311 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, BCL2, CA2, CA7, CDK6, EGFR, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 | 5.7272 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK | 5.72287 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR | 5.70907 |
[BP] GO:0040017 | positive regulation of locomotion | APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 5.59951 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 5.59192 |
[BP] GO:0009966 | regulation of signal transduction | ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 5.58981 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC | 5.53642 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, APP, BCL2, CDC25B, CHRM5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.5057 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 5.50198 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, PTGS2, TEK | 5.49382 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK | 5.48435 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, MPO, PTGS1, PTGS2, SRC | 5.48435 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, APP, BCL2, CDC25B, CHRM5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.46393 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TNKS, XDH | 5.38342 |
[BP] GO:0007165 | signal transduction | ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 | 5.26849 |
[BP] GO:0051239 | regulation of multicellular organismal process | ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HSPA1A, IDO1, INSR, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, TNKS2, XDH | 5.25224 |
[BP] GO:0016310 | phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS | 5.24367 |
[BP] GO:0080134 | regulation of response to stress | ADORA1, APP, CDK6, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IDO1, IGF1R, MET, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 4.93377 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 4.89857 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.88151 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 4.87196 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 4.87196 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.83334 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK | 4.81264 |
[BP] GO:0065009 | regulation of molecular function | ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH | 4.78127 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, MMP2, MPO, PPARA, PTGS2, SMAD3, SRC, TEK, TYR | 4.77332 |
[BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 4.74058 |
[BP] GO:0036293 | response to decreased oxygen levels | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 4.62108 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 4.61566 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, GBA2, HSPA1A, IDO1, MMP1, MMP2, MMP9, MPO, PIK3CB, SRC, XDH | 4.53637 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS | 4.52978 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 4.52978 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 4.52405 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 4.51946 |
[BP] GO:0050790 | regulation of catalytic activity | ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH | 4.48564 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, HSPA1A, IDO1, MPO | 4.46032 |
[BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK | 4.45817 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC | 4.43494 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 4.42881 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK | 4.38735 |
[BP] GO:0032847 | regulation of cellular pH reduction | BCL2, CA2, CA7 | 4.37946 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 4.33932 |
[BP] GO:0070482 | response to oxygen levels | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 4.33803 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APP, AXL, CDK6, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC | 4.27913 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 | 4.27913 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 | 4.27689 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, EGFR, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 | 4.27689 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC | 4.23613 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, APP, BCL2, CDC25B, EGFR, ESRRB, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 4.21975 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 4.21975 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, PTGS1, RORC | 4.21191 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 4.20314 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH | 4.20247 |
[BP] GO:0007213 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.19199 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 4.18559 |
[BP] GO:0032787 | None | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, IDO1, PPARA, PTGS1, PTGS2 | 4.12664 |
[BP] GO:0030522 | intracellular receptor signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC | 4.09468 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 | 3.91345 |
[BP] GO:0043401 | steroid hormone mediated signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC | 3.85585 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 3.84428 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3 | 3.81466 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 3.80529 |
[BP] GO:0044093 | positive regulation of molecular function | ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, XDH | 3.80003 |
[BP] GO:0051098 | regulation of binding | APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TNKS | 3.76102 |
[BP] GO:0038083 | peptidyl-tyrosine autophosphorylation | EGFR, IGF1R, INSR, KDR, SRC | 3.7571 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ADORA1, APP, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 3.72732 |
[BP] GO:1901652 | response to peptide | AKR1B1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, PTGS2, SRC, TEK | 3.70097 |
[BP] GO:0071407 | cellular response to organic cyclic compound | ALPL, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC | 3.68375 |
[BP] GO:0022414 | reproductive process | AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, INSR, MMP2, MMP9, PTGS2, SRC | 3.67132 |
[BP] GO:0095500 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.57071 |
[BP] GO:1903831 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.57071 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 3.57071 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APP, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR | 3.55605 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ADORA1, APP, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 3.52458 |
[BP] GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC | 3.52458 |
[BP] GO:0007346 | regulation of mitotic cell cycle | APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TNKS | 3.52103 |
[BP] GO:0051240 | positive regulation of multicellular organismal process | APP, AXL, BCL2, CA2, CHRM3, CYP1B1, EGFR, ESRRB, F3, HCAR2, HSPA1A, IDO1, KDR, MET, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK | 3.52103 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.52103 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1, MPO | 3.52103 |
[BP] GO:0006950 | response to stress | ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, IDO1, MMP2, MMP9, MPO, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK | 3.51641 |
[BP] GO:0051338 | regulation of transferase activity | ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS | 3.47059 |
[BP] GO:0030155 | regulation of cell adhesion | BCL2, CDK6, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK | 3.46511 |
[BP] GO:0048545 | response to steroid hormone | ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTGS2, SRC | 3.44835 |
[BP] GO:0031960 | response to corticosteroid | ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2, SRC | 3.42687 |
[BP] GO:0003018 | None | ADORA1, CHRM1, CHRM3, EGFR, PTGS2, SRC, TEK | 3.42687 |
[BP] GO:0043085 | positive regulation of catalytic activity | ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, XDH | 3.42687 |
[BP] GO:0031347 | regulation of defense response | ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK | 3.42687 |
[BP] GO:0051701 | interaction with host | AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC | 3.38286 |
[BP] GO:0072593 | reactive oxygen species metabolic process | BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MPO | 3.38286 |
[BP] GO:0009894 | regulation of catabolic process | ADORA1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 | 3.37353 |
[BP] GO:0050727 | regulation of inflammatory response | ADORA1, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK | 3.36555 |
[BP] GO:0051130 | positive regulation of cellular component organization | APP, AURKB, AXL, BCL2, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 | 3.34712 |
[BP] GO:0007271 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.34708 |
[BP] GO:0022900 | electron transport chain | AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH | 3.32496 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR | 3.27703 |
[BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH | 3.26674 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC | 3.25779 |
[BP] GO:0009755 | hormone-mediated signaling pathway | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC | 3.25038 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APP, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR | 3.24984 |
[BP] GO:0003006 | developmental process involved in reproduction | ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PTGS2, SRC | 3.24888 |
[BP] GO:2000377 | regulation of reactive oxygen species metabolic process | BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH | 3.22648 |
[BP] GO:0031399 | regulation of protein modification process | ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 3.22425 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, IDO1, MPO, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.22158 |
[BP] GO:0065007 | biological regulation | ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MPO, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 3.22158 |
[BP] GO:0010038 | response to metal ion | APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 | 3.22158 |
[BP] GO:0048585 | negative regulation of response to stimulus | ADORA1, BCL2, CDK6, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 3.19951 |
[BP] GO:0043408 | regulation of MAPK cascade | ADORA1, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH | 3.19951 |
[BP] GO:0042743 | hydrogen peroxide metabolic process | CYP1A1, CYP1A2, EGFR, MPO | 3.19951 |
[BP] GO:0048732 | gland development | BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR | 3.19951 |
[BP] GO:0006940 | None | ADORA1, CHRM1, CHRM2, CHRM3, PTGS2 | 3.18159 |
[BP] GO:0001775 | cell activation | ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, MPO, PIK3CA, PIK3CB, RORC, SMAD3, SRC | 3.17663 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, APP, EGFR, FLT3, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH | 3.17047 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.16861 |
[BP] GO:0010638 | positive regulation of organelle organization | AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 | 3.16763 |
[BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 3.16763 |
[BP] GO:0019538 | protein metabolic process | ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 | 3.16763 |
[BP] GO:0006082 | organic acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, IDO1, MPO, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.15734 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.14806 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH | 3.13942 |
[BP] GO:0043549 | regulation of kinase activity | ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 3.13414 |
[BP] GO:0006464 | cellular protein modification process | ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 | 3.13234 |
[BP] GO:0036211 | protein modification process | ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 | 3.13234 |
[BP] GO:0050793 | regulation of developmental process | APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, IDO1, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, XDH | 3.12439 |
[BP] GO:0042493 | response to drug | AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, KDR, PTGS2, SRC | 3.12134 |
[BP] GO:0009611 | response to wounding | ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 | 3.11373 |
[BP] GO:0009892 | negative regulation of metabolic process | ADORA1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH | 3.09293 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.08914 |
[BP] GO:0044267 | cellular protein metabolic process | ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 | 3.08492 |
[BP] GO:0002682 | regulation of immune system process | ADORA1, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, IDO1, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC | 3.07304 |
[BP] GO:0010907 | None | ESRRB, INSR, PPARA, SRC | 3.07196 |
[BP] GO:0043405 | regulation of MAP kinase activity | ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC | 3.05449 |
[BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, APP, CA2, CA7, EGFR, PTGS2 | 3.05445 |
[BP] GO:0009991 | response to extracellular stimulus | ALPL, AXL, BCL2, CYP1A1, EGFR, HSD11B2, MPO, PTGS2, SRC, TYR | 3.0542 |
[BP] GO:0019371 | None | CBR1, PTGS1, PTGS2 | 3.04283 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, PTGS2, SRC, TEK | 3.02218 |
[BP] GO:1903725 | regulation of phospholipid metabolic process | CHRM5, FABP3, FLT3, SRC, TEK | 3.01967 |
[BP] GO:0048010 | vascular endothelial growth factor receptor signaling pathway | AXL, KDR, PIK3CA, PIK3CB, SRC | 3.01967 |
[BP] GO:0018193 | peptidyl-amino acid modification | AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS | 3.00616 |
[BP] GO:0010810 | regulation of cell-substrate adhesion | BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK | 3.0041 |
[BP] GO:0009895 | negative regulation of catabolic process | ADORA1, BCL2, EGFR, HCAR2, MET, PIK3CA, PPARA, SMAD3 | 3.00036 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR | 2.99376 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, PTGS2, SRC, TEK | 2.99376 |
[BP] GO:0051049 | regulation of transport | ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC | 2.98723 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 2.97725 |
[BP] GO:0040008 | regulation of growth | APP, BCL2, CSNK2A1, EGFR, ESR2, HSPA1A, INSR, MPO, PIK3CA, PIM1, SMAD3, TNKS2 | 2.96832 |
[BP] GO:0010648 | negative regulation of cell communication | ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH | 2.94589 |
[BP] GO:0023057 | negative regulation of signaling | ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH | 2.93188 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 | 2.93188 |
[BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 2.93188 |
[BP] GO:0007193 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 | 2.92735 |
[BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, EGFR, MMP2, MMP9, PTGS2 | 2.92735 |
[BP] GO:0032101 | regulation of response to external stimulus | ADORA1, CYP19A1, EGFR, ESR1, F3, FABP4, IDO1, KDR, MET, PPARA, PTGS2, SMAD3, TEK | 2.88974 |
[BP] GO:0009115 | None | AOX1, XDH | 2.88974 |
[BP] GO:0051726 | regulation of cell cycle | APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TNKS | 2.87643 |
[BP] GO:0032496 | response to lipopolysaccharide | ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC | 2.86811 |
[BP] GO:0045859 | regulation of protein kinase activity | ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC | 2.8598 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.85176 |
[BP] GO:0032103 | positive regulation of response to external stimulus | EGFR, F3, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 | 2.85025 |
[BP] GO:0002009 | morphogenesis of an epithelium | BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 2.82145 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, AXL, CDK6, CYP1B1, EGFR, KDR, PTGS2, SRC | 2.82145 |
[BP] GO:0003013 | None | ADORA1, CHRM1, CHRM3, EGFR, PTGS2, SRC, TEK | 2.80515 |
[BP] GO:0043393 | regulation of protein binding | APP, AURKB, BCL2, MET, MMP9, PPARA, SRC | 2.80515 |
[BP] GO:0048511 | rhythmic process | AXL, BCL2, CSNK2A1, EGFR, ESR1, PPARA, RORC, SRC | 2.80395 |
[BP] GO:0051347 | positive regulation of transferase activity | ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS | 2.80003 |
[BP] GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH | 2.79849 |
[BP] GO:2000106 | regulation of leukocyte apoptotic process | AURKB, AXL, HCAR2, IDO1, PIK3CB | 2.79849 |
[BP] GO:0033273 | response to vitamin | ALPL, CYP1A1, EGFR, PTGS2, TYR | 2.79849 |
[BP] GO:0051384 | response to glucocorticoid | ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 | 2.77961 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.76781 |
[BP] GO:1904407 | positive regulation of nitric oxide metabolic process | EGFR, INSR, PTGS2, SMAD3 | 2.76721 |
[BP] GO:0045429 | positive regulation of nitric oxide biosynthetic process | EGFR, INSR, PTGS2, SMAD3 | 2.76721 |
[BP] GO:0019222 | regulation of metabolic process | ACHE, ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 2.72119 |
[BP] GO:0031401 | positive regulation of protein modification process | ADORA1, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 2.72119 |
[BP] GO:0051054 | positive regulation of DNA metabolic process | AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 | 2.71894 |
[BP] GO:0008285 | negative regulation of cell proliferation | ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, FABP3, HSPA1A, IDO1, PTGS2, SMAD3, XDH | 2.70847 |
[BP] GO:0002237 | response to molecule of bacterial origin | ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC | 2.69736 |
[BP] GO:1903727 | positive regulation of phospholipid metabolic process | FABP3, FLT3, SRC, TEK | 2.69554 |
[BP] GO:0007200 | None | CHRM1, CHRM2, CHRM3, CHRM5, ESR1 | 2.69252 |
[BP] GO:0071248 | cellular response to metal ion | CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 | 2.64599 |
[BP] GO:0051050 | positive regulation of transport | ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, HCAR2, INSR, PTGS2, SMAD3, SRC | 2.63257 |
[BP] GO:0008217 | None | ADORA1, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 | 2.63234 |
[BP] GO:2000379 | positive regulation of reactive oxygen species metabolic process | EGFR, INSR, PTGS2, SMAD3, XDH | 2.62834 |
[BP] GO:0050794 | regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MPO, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 2.62762 |
[BP] GO:0001954 | positive regulation of cell-matrix adhesion | CDK6, KDR, SMAD3, TEK | 2.62762 |
[BP] GO:2000811 | negative regulation of anoikis | BCL2, PIK3CA, SRC | 2.61168 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.61168 |
[BP] GO:0043065 | positive regulation of apoptotic process | BCL2, CYP1B1, F3, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH | 2.61168 |
[BP] GO:0051704 | multi-organism process | APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, EGFR, HSD11B2, HSPA1A, IDO1, INSR, KDR, MET, MMP1, MPO, SMAD3, SRC | 2.59648 |
[BP] GO:0044248 | cellular catabolic process | ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, GBA2, HSPA1A, IDO1, MPO, PIK3CB, SRC, XDH | 2.58195 |
[BP] GO:0043068 | positive regulation of programmed cell death | BCL2, CYP1B1, F3, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH | 2.57836 |
[BP] GO:0048869 | cellular developmental process | ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, MET, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC, TEK | 2.56993 |
[BP] GO:0031667 | response to nutrient levels | ALPL, BCL2, CYP1A1, EGFR, HSD11B2, MPO, PTGS2, SRC, TYR | 2.56668 |
[BP] GO:1904355 | positive regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.54084 |
[BP] GO:0043412 | macromolecule modification | ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 | 2.52795 |
[BP] GO:0010906 | None | ESRRB, INSR, PPARA, RORC, SRC | 2.51404 |
[BP] GO:2001242 | regulation of intrinsic apoptotic signaling pathway | BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC | 2.51404 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR | 2.50203 |
[BP] GO:0044057 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, EGFR, GPR35, HCAR2, PTGS2, SMAD3 | 2.49191 |
[BP] GO:0046110 | None | AOX1, XDH | 2.49191 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.49191 |
[BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.49139 |
[BP] GO:0032268 | regulation of cellular protein metabolic process | ADORA1, APP, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 2.48554 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.483 |
[BP] GO:2000116 | regulation of cysteine-type endopeptidase activity | CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH | 2.483 |
[BP] GO:0016137 | None | AKR1B1, AKR1B10, GBA2 | 2.48143 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA | 2.48143 |
[BP] GO:0033138 | positive regulation of peptidyl-serine phosphorylation | APP, BCL2, EGFR, PIK3CA, PTGS2 | 2.46789 |
[BP] GO:0006807 | nitrogen compound metabolic process | ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH | 2.4426 |
[BP] GO:0007186 | G-protein coupled receptor signaling pathway | ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GPR35, HCAR2, HTR6, INSR, PIK3CA, PIK3CB, SRC | 2.4426 |
[BP] GO:0051828 | entry into other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.43516 |
[BP] GO:0051806 | entry into cell of other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.43516 |
[BP] GO:0030260 | entry into host cell | AXL, EGFR, HSPA1A, MET, SRC | 2.43516 |
[BP] GO:0044409 | entry into host | AXL, EGFR, HSPA1A, MET, SRC | 2.43516 |
[BP] GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | EGFR, INSR, PTGS2, SMAD3 | 2.42482 |
[BP] GO:0010676 | None | ESRRB, INSR, PPARA, SRC | 2.42482 |
[BP] GO:0051900 | regulation of mitochondrial depolarization | BCL2, KDR, SRC | 2.42301 |
[BP] GO:0080135 | regulation of cellular response to stress | APP, CDK6, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, XDH | 2.39579 |
[BP] GO:0032210 | regulation of telomere maintenance via telomerase | AURKB, SRC, TNKS, TNKS2 | 2.39579 |
[BP] GO:0051893 | regulation of focal adhesion assembly | KDR, SMAD3, SRC, TEK | 2.36617 |
[BP] GO:0090109 | regulation of cell-substrate junction assembly | KDR, SMAD3, SRC, TEK | 2.36617 |
[BP] GO:0071241 | cellular response to inorganic substance | CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 | 2.3445 |
[BP] GO:0010942 | positive regulation of cell death | BCL2, CYP1B1, F3, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH | 2.33282 |
[BP] GO:0033674 | positive regulation of kinase activity | ADORA1, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 2.32993 |
[BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, AXL, BCL2, CYP1B1, SRC | 2.31478 |
[BP] GO:0071498 | cellular response to fluid shear stress | CA2, PTGS2, SRC | 2.30622 |
[BP] GO:0032094 | None | CYP1A1, HSD11B2, MPO | 2.30622 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 2.30622 |
[BP] GO:0001525 | angiogenesis | CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK | 2.29949 |
[BP] GO:0050801 | ion homeostasis | APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, PIK3CB, SMAD3 | 2.29949 |
[BP] GO:1903391 | regulation of adherens junction organization | KDR, SMAD3, SRC, TEK | 2.29511 |
[BP] GO:0045428 | regulation of nitric oxide biosynthetic process | EGFR, INSR, PTGS2, SMAD3 | 2.29511 |
[BP] GO:0030520 | intracellular estrogen receptor signaling pathway | ESR1, ESR2, SRC | 2.25438 |
[BP] GO:0009891 | positive regulation of biosynthetic process | APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, PPARA, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2 | 2.25036 |
[BP] GO:0033031 | positive regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.25036 |
[BP] GO:0070213 | None | TNKS, TNKS2 | 2.25036 |
[BP] GO:0006145 | None | AOX1, XDH | 2.25036 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.25036 |
[BP] GO:0034502 | protein localization to chromosome | AURKB, ESR1, TNKS, TNKS2 | 2.24777 |
[BP] GO:0048729 | tissue morphogenesis | BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 2.24288 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APP, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC | 2.23716 |
[BP] GO:0043406 | positive regulation of MAP kinase activity | ADORA1, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC | 2.2353 |
[BP] GO:0007187 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, HTR6 | 2.23111 |
[BP] GO:0043207 | response to external biotic stimulus | ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SMAD3, SRC | 2.22858 |
[BP] GO:1904356 | regulation of telomere maintenance via telomere lengthening | AURKB, SRC, TNKS, TNKS2 | 2.22701 |
[BP] GO:0019229 | None | CHRM1, CHRM3, EGFR, PTGS2 | 2.22701 |
[BP] GO:0050728 | negative regulation of inflammatory response | ADORA1, CYP19A1, PPARA, SMAD3, TEK | 2.21894 |
[BP] GO:2000209 | regulation of anoikis | BCL2, PIK3CA, SRC | 2.21727 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.21727 |
[BP] GO:0031324 | negative regulation of cellular metabolic process | APP, AURKB, BCL2, CSNK2A1, CYP2D6, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH | 2.21478 |
[BP] GO:0048608 | reproductive structure development | AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC | 2.18798 |
[BP] GO:0051894 | None | KDR, SMAD3, TEK | 2.16628 |
[BP] GO:0050789 | regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MPO, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 2.15721 |
[BP] GO:0070372 | regulation of ERK1 and ERK2 cascade | APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK | 2.15278 |
[BP] GO:0048731 | system development | ACHE, ADORA1, ALPL, CHRM1, CHRM2, CHRM3, MMP9, PIK3CA, SMAD3, SRC, TEK | 2.1468 |
[BP] GO:0003008 | None | ADORA1, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, EGFR, HSD11B2, INSR, PIK3CA, PTGS2, SRC, TEK, TYR | 2.13875 |
[BP] GO:0045787 | positive regulation of cell cycle | APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC | 2.13492 |
[BP] GO:2000573 | positive regulation of DNA biosynthetic process | AURKB, SRC, TNKS, TNKS2 | 2.13492 |
[BP] GO:0010675 | None | ESRRB, INSR, PPARA, RORC, SRC | 2.13118 |
[BP] GO:0050927 | None | F3, KDR, SMAD3 | 2.12218 |
[BP] GO:0043434 | None | FABP3, HSD11B2, INSR, PPARA, PTGS2, SRC, TEK | 2.12218 |
[BP] GO:0080090 | regulation of primary metabolic process | ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 2.12218 |
[BP] GO:0016477 | cell migration | AXL, CYP1B1, EGFR, FUT7, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK | 2.11994 |
[BP] GO:0060255 | regulation of macromolecule metabolic process | ACHE, ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 2.10681 |
[BP] GO:0009605 | response to external stimulus | ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, EGFR, HSD11B2, IDO1, MPO, PTGS2, SMAD3, SRC, TYR | 2.09794 |
[BP] GO:0051128 | regulation of cellular component organization | APP, AURKB, AXL, BCL2, CSNK2A1, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 | 2.09391 |
[BP] GO:1901575 | None | ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, GBA2, HSPA1A, IDO1, XDH | 2.09387 |
[BP] GO:0097746 | None | ADORA1, CHRM1, CHRM3, EGFR, PTGS2 | 2.09387 |
[BP] GO:0035296 | None | ADORA1, CHRM1, CHRM3, EGFR, PTGS2 | 2.09387 |
[BP] GO:0032355 | response to estradiol | CYP1A2, EGFR, ESR1, ESRRA, PTGS2 | 2.09387 |
[BP] GO:0009607 | response to biotic stimulus | ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SMAD3, SRC | 2.09082 |
[BP] GO:0031323 | regulation of cellular metabolic process | ACHE, ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 2.08742 |
[BP] GO:0050926 | None | F3, KDR, SMAD3 | 2.08742 |
[BP] GO:1904353 | regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.08742 |
[BP] GO:1903393 | None | KDR, SMAD3, TEK | 2.08742 |
[BP] GO:0010564 | regulation of cell cycle process | APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, TNKS | 2.0866 |
[BP] GO:0040014 | regulation of multicellular organism growth | APP, BCL2, PIK3CA, TNKS2 | 2.08609 |
[BP] GO:0046541 | None | CHRM1, CHRM3 | 2.08609 |
[BP] GO:0043696 | None | CDK6, ESRRB | 2.08609 |
[BP] GO:0043697 | None | CDK6, ESRRB | 2.08609 |
[BP] GO:0010641 | None | F3, SRC | 2.08609 |
[BP] GO:0007598 | None | F10, F3 | 2.08609 |
[BP] GO:0051094 | positive regulation of developmental process | APP, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, IDO1, INSR, KDR, PIM1, PTGS2, SMAD3, SRC, TEK | 2.08429 |
[BP] GO:1903522 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, EGFR, PTGS2 | 2.08363 |
[BP] GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, PPARA, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2 | 2.08327 |
[BP] GO:0045913 | None | ESRRB, INSR, PPARA, SRC | 2.06643 |
[BP] GO:1904357 | None | SRC, TNKS, TNKS2 | 2.05356 |
[BP] GO:0048660 | regulation of smooth muscle cell proliferation | AKR1B1, EGFR, MMP2, MMP9, PTGS2 | 2.05352 |
[BP] GO:0042180 | None | AKR1B1, AKR1B10, CYP19A1, IDO1 | 2.04773 |
[BP] GO:0051052 | regulation of DNA metabolic process | AURKB, EGFR, IGF1R, INSR, PIK3CA, SRC, TNKS, TNKS2 | 2.04303 |
[BP] GO:2000026 | regulation of multicellular organismal development | APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, F3, IDO1, INSR, KDR, PIM1, PTGS2, SMAD3, SRC, TEK, XDH | 2.03434 |
[BP] GO:1900182 | positive regulation of protein localization to nucleus | APP, EGFR, PTGS2, SMAD3, SRC | 2.02792 |
[BP] GO:0006352 | DNA-templated transcription, initiation | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.02775 |
[BP] GO:2000108 | None | HCAR2, IDO1, PIK3CB | 2.01721 |
[BP] GO:0033032 | regulation of myeloid cell apoptotic process | BCL2, HCAR2, PIK3CB | 2.01721 |
[BP] GO:0033135 | regulation of peptidyl-serine phosphorylation | APP, BCL2, EGFR, PIK3CA, PTGS2 | 2.01721 |
[BP] GO:0051246 | regulation of protein metabolic process | ADORA1, APP, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 2.01574 |
[BP] GO:0050880 | None | ADORA1, CHRM1, CHRM3, EGFR, PTGS2 | 2.00468 |
[BP] GO:0071900 | regulation of protein serine/threonine kinase activity | ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC | 2.00318 |
[BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC | 2.00318 |
[BP] GO:2000021 | regulation of ion homeostasis | ADORA1, BCL2, CA2, CA7, KDR, SRC | 2.00318 |
[CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR6, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR | 3.70023 |
[CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GBA2, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SMAD3, SRC, TEK | 3.52458 |
[CC] GO:0031226 | intrinsic component of plasma membrane | ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, F10, F3, FLT3, GPR35, HTR6, IGF1R, INSR, KDR, MET, TEK | 3.25488 |
[CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR6, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TEK, TYR | 3.16763 |
[CC] GO:0016323 | basolateral plasma membrane | ADORA1, CA2, CA4, CA9, CHRM3, EGFR, TEK | 3.02591 |
[CC] GO:0044432 | endoplasmic reticulum part | APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1 | 2.9249 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KDR, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TNKS, TNKS2, TYR, XDH | 2.6046 |
[CC] GO:0098590 | plasma membrane region | ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, INSR, MET, PTGS2, SRC, TEK | 2.57587 |
[CC] GO:0044459 | plasma membrane part | ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DUSP3, EGFR, F10, F3, FLT3, GPR35, HTR6, IGF1R, INSR, KDR, MET, PTGS2, SRC, TEK | 2.51404 |
[CC] GO:0031233 | None | CA4, F10, F3 | 2.35985 |
[CC] GO:0005789 | endoplasmic reticulum membrane | BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2 | 2.29762 |
[CC] GO:0045202 | None | ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR | 2.26287 |
[CC] GO:0005783 | None | ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, HSPA1A, KDR, PTGS2, PTPN1, XDH | 2.21727 |
[CC] GO:0005887 | integral component of plasma membrane | ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, HTR6, IGF1R, INSR, KDR, MET, TEK | 2.08845 |
[CC] GO:0045121 | membrane raft | APP, EGFR, INSR, KDR, PTGS2, SRC, TEK | 2.0236 |
[CC] GO:0098857 | membrane microdomain | APP, EGFR, INSR, KDR, PTGS2, SRC, TEK | 2.01032 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TNKS, TNKS2, TYR, XDH | 14.2191 |
[MF] GO:0046914 | transition metal ion binding | ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH | 13.2127 |
[MF] GO:0043167 | ion binding | ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH | 11.3344 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 9.8151 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, NQO2, PTGS1, PTGS2, TYR, XDH | 8.8885 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK | 7.34323 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, IDO1, MPO, PTGS1, PTGS2, SRC | 7.20417 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 7.10272 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, IDO1, MPO, PTGS1, PTGS2, SRC | 6.95172 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3, TNKS | 6.67189 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK | 6.59965 |
[MF] GO:0048037 | cofactor binding | AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B2, HSD17B1, IDO1, MPO, NQO2, PTGS1, PTGS2, SRC, XDH | 6.42343 |
[MF] GO:0043169 | cation binding | ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MMP1, MMP2, MMP9, MPO, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TNKS, TNKS2, TYR, XDH | 6.39364 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 6.36717 |
[MF] GO:0016907 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.32908 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK | 6.082 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.07867 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH | 5.87786 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK | 5.7311 |
[MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK | 5.61245 |
[MF] GO:0046872 | metal ion binding | ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MMP1, MMP2, MMP9, MPO, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TNKS, TNKS2, TYR, XDH | 5.4863 |
[MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 5.28834 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 5.16594 |
[MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 5.00788 |
[MF] GO:0004879 | nuclear receptor activity | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 5.00788 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.95528 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK | 4.95253 |
[MF] GO:0042562 | hormone binding | ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NQO2 | 4.94505 |
[MF] GO:0005496 | steroid binding | ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC | 4.91764 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 4.91177 |
[MF] GO:0043560 | insulin receptor substrate binding | IGF1R, INSR, PIK3CA, PIK3CB | 4.80768 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK | 4.76329 |
[MF] GO:0003707 | steroid hormone receptor activity | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 4.5902 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TYR | 4.42881 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH | 4.33932 |
[MF] GO:0005506 | iron ion binding | ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH | 4.33888 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK | 4.31405 |
[MF] GO:0099528 | None | CHRM1, CHRM2, CHRM3, CHRM5, HTR6 | 4.19199 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 4.10482 |
[MF] GO:0015464 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.98313 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 | 3.84003 |
[MF] GO:0099600 | transmembrane receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, TEK | 3.54751 |
[MF] GO:0004888 | transmembrane signaling receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, F3, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, TEK | 3.54751 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR | 3.52458 |
[MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK | 3.49032 |
[MF] GO:0008289 | lipid binding | AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC | 3.42687 |
[MF] GO:0008227 | None | CHRM1, CHRM2, CHRM3, CHRM5, HTR6 | 3.40621 |
[MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.34708 |
[MF] GO:0004716 | signal transducer, downstream of receptor, with protein tyrosine kinase activity | EGFR, INSR, KDR | 3.25122 |
[MF] GO:0043168 | anion binding | AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH | 3.24838 |
[MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.24107 |
[MF] GO:0004629 | None | ADORA1, CHRM1, CHRM3, CHRM5 | 3.19951 |
[MF] GO:0036094 | small molecule binding | ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH | 3.15139 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC | 3.0675 |
[MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 3.05308 |
[MF] GO:0004666 | prostaglandin-endoperoxide synthase activity | PTGS1, PTGS2 | 2.88974 |
[MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.88974 |
[MF] GO:0003845 | None | HSD11B1, HSD11B2 | 2.88974 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC | 2.84135 |
[MF] GO:0000166 | nucleotide binding | AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH | 2.75681 |
[MF] GO:1901265 | nucleoside phosphate binding | AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH | 2.75504 |
[MF] GO:0016903 | None | AKR1B1, AKR1B10, AOX1, XDH | 2.65832 |
[MF] GO:0140096 | catalytic activity, acting on a protein | AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, SRC, TEK | 2.50568 |
[MF] GO:0019902 | phosphatase binding | BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 | 2.4426 |
[MF] GO:1901363 | heterocyclic compound binding | ADORA1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH | 2.34335 |
[MF] GO:0005524 | ATP binding | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK | 2.31653 |
[MF] GO:0042802 | identical protein binding | ACHE, AOX1, APP, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, SMAD3, TYR, XDH | 2.31478 |
[MF] GO:0030594 | None | CHRM1, CHRM2, CHRM3, CHRM5, HTR6 | 2.30053 |
[MF] GO:0097159 | organic cyclic compound binding | ADORA1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MPO, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH | 2.29949 |
[MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.25036 |
[MF] GO:0051425 | None | APP, INSR | 2.25036 |
[MF] GO:0032559 | adenyl ribonucleotide binding | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK | 2.22615 |
[MF] GO:0030554 | adenyl nucleotide binding | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK | 2.19778 |
[MF] GO:0042578 | None | ADORA1, ALPL, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 | 2.1681 |
[MF] GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | EGFR, MET, PIK3CA, PIK3CB | 2.09387 |
[MF] GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | ALOX5, IDO1, PTGS2 | 2.08742 |
[MF] GO:0030284 | estrogen receptor activity | ESR1, ESR2 | 2.08609 |
[MF] GO:0043559 | insulin binding | IGF1R, INSR | 2.08609 |
[MF] GO:0004435 | None | CHRM1, CHRM3, CHRM5 | 2.05356 |
[MF] GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | ALOX5, IDO1, PTGS2 | 2.05356 |
[MF] GO:0052813 | phosphatidylinositol bisphosphate kinase activity | EGFR, MET, PIK3CA, PIK3CB | 2.04773 |
[MF] GO:0019838 | growth factor binding | EGFR, IGF1R, INSR, KDR, TEK | 2.02792 |
[MF] GO:0019899 | enzyme binding | APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HSPA1A, MET, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2 | 2.00317 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R | 10.5735 |
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA9, CA14 | 10.5735 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A | 8.1024 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 8.4288 |
Pathways in cancer_Homo sapiens_hsa05200 | SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, CDK6, PIK3CA, BCL2, MET | 6.9322 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.777 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 | 7.202 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CHRM2, CDK6, CHRM1, PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R | 6.7724 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R | 6.8204 |
Cholinergic synapse_Homo sapiens_hsa04725 | CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, BCL2, PIK3CB | 6.6621 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 | 5.6878 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R | 5.6878 |
Metabolic pathways_Homo sapiens_hsa01100 | CBR1, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 | 5.5385 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B | 5.5385 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R | 5.6706 |
Melanoma_Homo sapiens_hsa05218 | CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R | 5.421 |
cAMP signaling pathway_Homo sapiens_hsa04024 | CHRM2, HCAR2, HTR6, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA | 5.0267 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 | 5.375 |
Focal adhesion_Homo sapiens_hsa04510 | PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R | 4.9983 |
Hepatitis B_Homo sapiens_hsa05161 | CDK6, SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 | 4.8894 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB, EGFR | 4.8483 |
Ras signaling pathway_Homo sapiens_hsa04014 | PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R | 4.6757 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 | 5.1445 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 | 5.3367 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9, EGFR | 5.305 |
Serotonergic synapse_Homo sapiens_hsa04726 | APP, HTR6, CYP2D6, ALOX5, PTGS2, PTGS1 | 4.4968 |
VEGF signaling pathway_Homo sapiens_hsa04370 | PIK3CA, SRC, KDR, PIK3CB, PTGS2 | 4.5683 |
Glioma_Homo sapiens_hsa05214 | CDK6, PIK3CA, PIK3CB, EGFR, IGF1R | 4.4786 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | CHRM2, CHRM3, HTR6, CHRM1, GPR35, ADORA3, CHRM5, ADORA1 | 4.1635 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A | 4.4968 |
Pancreatic cancer_Homo sapiens_hsa05212 | CDK6, SMAD3, PIK3CA, PIK3CB, EGFR | 4.4604 |
FoxO signaling pathway_Homo sapiens_hsa04068 | SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R | 4.1524 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | PIK3CA, SRC, PIK3CB, ESR1, ESR2 | 4.3017 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | PIK3CA, FLT3, PIK3CB, MET, EGFR | 4.4423 |
Endocytosis_Homo sapiens_hsa04144 | SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A | 3.514 |
Prostate cancer_Homo sapiens_hsa05215 | PIK3CA, BCL2, PIK3CB, EGFR, IGF1R | 3.9154 |
Calcium signaling pathway_Homo sapiens_hsa04020 | CHRM2, CHRM3, HTR6, CHRM1, CHRM5, EGFR | 3.5063 |
Small cell lung cancer_Homo sapiens_hsa05222 | CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 | 3.9755 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PIK3CA, INSR, PIK3CB, PPARA | 3.5154 |
Toxoplasmosis_Homo sapiens_hsa05145 | PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A | 3.409 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB | 3.3892 |
Measles_Homo sapiens_hsa05162 | CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A | 3.1706 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | CDK6, PIK3CA, PIK3CB, EGFR | 3.5154 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R | 3.0921 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIK3CA, BCL2, PIM1, AOX1, PIK3CB | 2.9112 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | PIK3CA, SRC, PIK3CB, PTGS2, EGFR | 2.9112 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | PIK3CA, ADORA3, INSR, ADORA1, PIK3CB | 2.8156 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.512 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | CDK6, SMAD3, PIK3CA, PIK3CB | 3.1706 |
ErbB signaling pathway_Homo sapiens_hsa04012 | PIK3CA, SRC, PIK3CB, EGFR | 2.9115 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, MPO, IGF1R | 2.6844 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | PIK3CA, PIK3CB, CDC25B, IGF1R | 2.7547 |
Colorectal cancer_Homo sapiens_hsa05210 | SMAD3, PIK3CA, BCL2, PIK3CB | 3.409 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A | 2.5027 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | PIK3CA, INSR, PIK3CB, IGF1R | 2.8156 |
TNF signaling pathway_Homo sapiens_hsa04668 | PIK3CA, PIK3CB, PTGS2, MMP9 | 2.5885 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5, PTGS2, PTGS1 | 3.409 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | PIK3CA, SRC, PIK3CB, MET | 3.0849 |
Platelet activation_Homo sapiens_hsa04611 | PIK3CA, SRC, PIK3CB, PTGS1 | 2.4559 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | PIK3CA, SRC, PIK3CB, ESR1 | 2.5027 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.2559 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, PIK3CA, INSR, PIK3CB | 4.1014 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | PIK3CA, MMP2, PIK3CB, MMP9 | 2.5027 |
Hepatitis C_Homo sapiens_hsa05160 | PIK3CA, PIK3CB, PPARA, EGFR | 2.3313 |
AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, INSR, PIK3CB, IGF1R | 2.4365 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, PIK3CA, INSR, PIK3CB | 2.2752 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | PIK3CA, INSR, PIK3CB, EGFR | 2.2381 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PIK3CA, INSR, PIK3CB, PPARA | 2.1742 |
Viral carcinogenesis_Homo sapiens_hsa05203 | CDK6, PIK3CA, SRC, PIK3CB | 1.7652 |
MAPK signaling pathway_Homo sapiens_hsa04010 | DUSP3, EGFR, CDC25B, HSPA1A | 1.474 |
Apoptosis_Homo sapiens_hsa04210 | PIK3CA, BCL2, PIK3CB | 1.4781 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET, EGFR | 1.429 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.2833 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.2956 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | PIK3CA, SRC, PIK3CB | 1.8447 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2, EGFR | 1.9169 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB | 1.429 |
Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3071 |
Hippo signaling pathway_Homo sapiens_hsa04390 | SMAD3 | 0.3315 |
Phagosome_Homo sapiens_hsa04145 | MPO | 0.3315 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | PIK3CA, PIK3CB, EGFR | 1.8193 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | PIK3CA, BCL2, PIK3CB | 1.6415 |
Spliceosome_Homo sapiens_hsa03040 | HSPA1A | 0.3711 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | SMAD3, PIK3CA, PIK3CB | 1.7897 |
Influenza A_Homo sapiens_hsa05164 | PIK3CA, PIK3CB, HSPA1A | 1.2731 |
Cell cycle_Homo sapiens_hsa04110 | CDK6, SMAD3, CDC25B | 1.6082 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.3863 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, BCL2, PTGS2 | 1.8965 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.3944 |
HTLV-I infection_Homo sapiens_hsa05166 | SMAD3, PIK3CA, PIK3CB | 0.9252 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | PIK3CA, SRC, PIK3CB | 1.2139 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | BCL2, HSPA1A | 0.7324 |
Tuberculosis_Homo sapiens_hsa05152 | SRC, BCL2 | 0.7001 |
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PIK3CA, PIK3CB | 0.8533 |
Osteoclast differentiation_Homo sapiens_hsa04380 | PIK3CA, PIK3CB | 0.8623 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.8428 |
Wnt signaling pathway_Homo sapiens_hsa04310 | SMAD3, CSNK2A1 | 0.8377 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.4598 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.4598 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | PTGS2 | 0.4598 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.4733 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.486 |
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | PIK3CA, PIK3CB | 1.0142 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.4912 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.4912 |
Taste transduction_Homo sapiens_hsa04742 | CHRM3 | 0.4994 |
Salivary secretion_Homo sapiens_hsa04970 | CHRM3 | 0.4912 |
TGF-beta signaling pathway_Homo sapiens_hsa04350 | SMAD3 | 0.4978 |
T cell receptor signaling pathway_Homo sapiens_hsa04660 | PIK3CA, PIK3CB | 1.0248 |
Insulin secretion_Homo sapiens_hsa04911 | CHRM3 | 0.4965 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.4912 |
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PIK3CA, PIK3CB | 1.0906 |
Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.0508 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.4994 |
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PIK3CA, PIK3CB | 1.0623 |
Renal cell carcinoma_Homo sapiens_hsa05211 | PIK3CA, PIK3CB, MET | 2.2752 |
Pancreatic secretion_Homo sapiens_hsa04972 | CHRM3, CA2 | 1.0742 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1, TEK | 1.1119 |
Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.5211 |
Gap junction_Homo sapiens_hsa04540 | SRC, EGFR | 1.1252 |
Leishmaniasis_Homo sapiens_hsa05140 | PTGS2 | 0.5381 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP1A2, CYP1A1, AOX1 | 2.2817 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET, EGFR | 2.2443 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5478 |
Endometrial cancer_Homo sapiens_hsa05213 | PIK3CA, PIK3CB, EGFR | 2.5153 |
Bile secretion_Homo sapiens_hsa04976 | CA2 | 0.5455 |
p53 signaling pathway_Homo sapiens_hsa04115 | CDK6 | 0.5501 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2D6, CYP1A2, AOX1 | 2.2381 |
B cell receptor signaling pathway_Homo sapiens_hsa04662 | PIK3CA, PIK3CB | 1.2553 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.5725 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.5698 |
Gastric acid secretion_Homo sapiens_hsa04971 | CHRM3, CA2 | 1.2488 |
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PIK3CA, PIK3CB | 1.2989 |
Complement and coagulation cascades_Homo sapiens_hsa04610 | F10, F3 | 1.2056 |
Long-term depression_Homo sapiens_hsa04730 | IGF1R | 0.5941 |
Inositol phosphate metabolism_Homo sapiens_hsa00562 | PIK3CA, PIK3CB | 1.2731 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | PIK3CA, INSR, PIK3CB | 2.6026 |
mTOR signaling pathway_Homo sapiens_hsa04150 | PIK3CA, PIK3CB | 1.3907 |
Legionellosis_Homo sapiens_hsa05134 | HSPA1A | 0.6247 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | SMAD3, RORC | 1.3306 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.3952 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.6509 |
Malaria_Homo sapiens_hsa05144 | MET | 0.6635 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.6735 |
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | AOX1 | 0.6684 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | XDH | 0.6755 |
Sphingolipid metabolism_Homo sapiens_hsa00600 | GBA2 | 0.6735 |
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | PIK3CA, PIK3CB | 1.5936 |
Prion diseases_Homo sapiens_hsa05020 | HSPA1A | 0.7749 |
African trypanosomiasis_Homo sapiens_hsa05143 | IDO1 | 0.7749 |
Dorso-ventral axis formation_Homo sapiens_hsa04320 | EGFR | 0.8529 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.8176 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2 | 0.8377 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.8824 |
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | AOX1 | 0.8377 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.8576 |
Tyrosine metabolism_Homo sapiens_hsa00350 | AOX1, TYR | 1.7786 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.8274 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.8386 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.7652 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.8529 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.0933 |
Other glycan degradation_Homo sapiens_hsa00511 | GBA2 | 0.9991 |
Folate biosynthesis_Homo sapiens_hsa00790 | ALPL | 1.0816 |
Vitamin B6 metabolism_Homo sapiens_hsa00750 | AOX1 | 1.3907 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 3.2677 |