TCM Prescription: Bao Ji Pills



Prescription Description
Prescription IDTCMF3358
Pinyin NameBao Ji Wan
Chinese Name保济丸
English NameBao Ji Pills
Function Description腹痛, 腹泻, 晕动病, 感冒
IndicationsAbdominal pain disorder, Common cold disorder, Dyspepsia, Enteritis, Diarrhea, Common cold, Motion sickness
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
ME05.1 [Diarrhoea, 腹泻 ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
NF08.3 [Motion sickness, 晕动病 ];
Human Tissues Associated with IndicationLung, Intestine, Stomach, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH695 Uncaria rhynchophylla 钩藤 TCMH695 ITSAM939-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH1024 Tribulus terrestris 蒺藜 TCMH1024 ITSAJ4258-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH2086 Trichosanthes kirilowii 天花粉 TCMH2086 ITSAO4359-14
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH925 Exocarpium citri grandis 化橘红 TCMH925
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH2486 Coix lacryma- jobi var. ma - yuen 薏苡仁 TCMH2486
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH2722 Perilla frutescens var. arguta 紫苏叶 TCMH2722 ITSAF2620-14
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH512 Fructus amomi rotundus 豆蔻 TCMH512
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH436 Fructus oryzae germinatus 稻芽 TCMH436
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1174 Mycobacterium bovis BCG
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1184 Mycobacterium fortuitum
TCMT1185 Mycobacterium phlei
TCMT1186 Plasmodium yoelii yoelii
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1192 Bacteria
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1196 Salmonella
TCMT1198 Serratia marcescens
TCMT1199 Streptococcus sp. 'group A'
TCMT1200 Bacillus thuringiensis
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1202 Mycoplasma hominis
TCMT1203 Mycoplasma pneumoniae
TCMT1204 Clostridium perfringens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1216 Vibrio cholerae
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1220 Streptococcus pneumoniae R6
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1244 Staphylococcus saprophyticus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1252 Alcaligenes faecalis
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1262 Mycoplasma putrefaciens
TCMT1266 Mycobacterium abscessus
TCMT1267 Mycobacterium chelonae
TCMT1271 Shigella flexneri
TCMT1272 Campylobacter jejuni
TCMT1273 Pseudomonas putida
TCMT1274 Shigella boydii
TCMT1276 Klebsiella
TCMT1277 Serratia
TCMT1278 Pseudomonas
TCMT1281 Clostridium difficile
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1287 Bacillus subtilis subsp. spizizenii ATCC 6633
TCMT1289 Shigella dysenteriae
TCMT1290 Acinetobacter calcoaceticus
TCMT1291 Haemophilus parainfluenzae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1299 Morganella morganii
TCMT1300 Enterobacter
TCMT1301 Klebsiella sp.
TCMT1303 Bacillus
TCMT1304 Staphylococcus capitis
TCMT1305 Salmonella enteritidis
TCMT1307 Penicillium marneffei
TCMT1309 Aspergillus clavatus
TCMT1310 Enterococcus hirae
TCMT1314 Streptococcus viridans
TCMT1315 Streptococcus sp.
TCMT1317 Staphylococcus lentus
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1326 Shigella
TCMT1331 Acinetobacter sp.
TCMT1332 Bacillus licheniformis
TCMT1334 Chlamydia trachomatis
TCMT1340 Staphylococcus faecalis
TCMT1341 Streptococcus oralis
TCMT1342 Streptococcus salivarius
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1345 Prevotella loescheii
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1356 Campylobacter coli
TCMT1358 Bacteroides vulgatus
TCMT1361 Neisseria meningitidis
TCMT1362 Bordetella pertussis
TCMT1363 Peptostreptococcus anaerobius
TCMT1366 Prevotella bivia
TCMT1370 Prevotella melaninogenica
TCMT1371 Veillonella parvula
TCMT1375 Clostridium tetani
TCMT1377 Staphylococcus lugdunensis
TCMT1378 Acinetobacter haemolyticus
TCMT1381 Listeria innocua
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1383 Streptomyces griseus
TCMT1388 Prevotella disiens
TCMT1389 Klebsiella oxytoca
TCMT1393 Vibrio sp.
TCMT1394 Mycobacterium aurum
TCMT1395 Staphylococcus sp.
TCMT1396 Fusobacterium
TCMT1399 Chlamydophila pneumoniae
TCMT1400 Mycobacterium mageritense
TCMT1401 Staphylococcus warneri
TCMT1402 Staphylococcus cohnii
TCMT1403 Streptococcus constellatus
TCMT1404 Streptococcus intermedius
TCMT1406 Mycobacterium leprae
TCMT1407 Aeromonas punctata
TCMT1408 Colletotrichum gloeosporioides
TCMT1409 Escherichia coli O157:H7
TCMT1410 Listeria monocytogenes
TCMT1411 Vibrio parahaemolyticus
TCMT1412 Salmonella typhimurium
TCMT1413 Vibrio splendidus
TCMT1414 Vibrio vulnificus
TCMT1415 Vibrio fluvialis
TCMT1416 Plesiomonas shigelloides
TCMT1417 Aeromonas sobria
TCMT1418 Enterobacteriaceae
TCMT1420 Klebsiella pneumoniae subsp. ozaenae
TCMT1421 Vibrio mimicus
TCMT1422 Clostridium histolyticum
TCMT1423 Peptostreptococcus
TCMT1424 Haemophilus ducreyi
TCMT1425 Moraxella bovis
TCMT1427 Proteus inconstans
TCMT1429 Acinetobacter pittii
TCMT1431 Coxiella burnetii
TCMT1432 Serratia sp.
TCMT1434 Plesiomonas
TCMT1435 Corynebacterium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.6235
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, MPO, PPARA, PTGS2, RORC, SRC, TYR 12.026
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.8393
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, MPO, NISCH, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 11.6363
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, GLO1, HMGCR, IDO1, MPO, NISCH, PIM1, PPARA, PTGS2, TBXAS1, TYR, XDH 10.3727
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, MPO, PTGS2, RORC, SRC, TYR 9.89285
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, MPO, PPARA, PTGS2, RORC, SRC, TYR 9.37642
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MPO, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 8.53017
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, MPO, PPARA, PTGS2, RORC, SRC, TYR 8.13569
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MAOA, MPO, PHF8, PTGS2, TBXAS1, TYR, XDH 8.13501
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PTGS2, TBXAS1 7.95375
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK3, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, MPO, PHF8, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TOP2A, TYR 7.70862
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 7.31184
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, RORC, SRC, TYR 7.31184
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 7.31184
[BP] GO:0042493 response to drug ABCG2, AKR1B1, APEX1, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HMGCR, HSD11B2, KDR, PTGS2, SRC 7.22592
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.19669
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, DRD2, NISCH 7.15339
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, HMGCR, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 7.09936
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MAOA, MET, NISCH, PPARA, PTGS2, SRC, TNKS, TNKS2, XDH 7.01312
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 6.79126
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, HMGCR, KDR, SRC 6.69079
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, DRD1, DRD2, HCAR2, HMGCR, KDR, PTGS2, SRC, TNKS, TNKS2 6.67295
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.37999
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.31744
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.80172
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.73936
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, MPO, NISCH, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 5.72392
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 5.72392
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TNKS 5.62654
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 5.60649
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, DYRK3, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC 5.53854
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, XDH 5.48808
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.46596
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, HCAR2, HMGCR, HTR6, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.44181
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, DYRK3, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC 5.44181
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, HCAR2, HMGCR, HTR6, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.41875
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 5.36269
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.36269
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, NISCH, PTGS2, SRC 5.30762
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, MPO, NISCH, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.24466
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 5.24466
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CLK1, CSNK2A1, CYP1A1, CYP1A2, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, IDO1, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 5.24466
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PTGS2, SRC 5.18219
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, PTGS2, SRC 4.92162
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, DYRK3, GLO1, HMGCR, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC 4.88168
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, F3, FLT3, HCAR2, HMGCR, HTR6, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.86207
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, MPO, NISCH, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 4.83106
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, SRC, TNKS, TOP2A 4.73317
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC 4.72576
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD2, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 4.69952
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, HCAR2, PTGS2, TNKS, TNKS2 4.67524
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, MPO, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR 4.59619
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, F3, FLT3, HCAR2, HMGCR, HTR6, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.55941
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TYR 4.51657
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, NISCH, PTGS2, SRC 4.45395
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, HTR6 4.44372
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 4.43989
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PHF8, PIM1, PPARA, PTGS2, RORC, SRC, TYR 4.42742
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TNKS 4.42064
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 4.41907
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PPARA, PTGS2, TBXAS1 4.22633
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, PIM1, SRC 4.22539
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 4.19078
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, NISCH, PTGS2, SRC 4.13423
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.1312
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, GBA2, HMGCR, MAOA, TYR 4.11671
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.09792
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CNR1, CNR2, CYP19A1, DRD2, DYRK1A, DYRK3, ESR1, F3, FABP4, HMGCR, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, XDH 4.07952
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MET, MMP12, PPARA, PTGS2 4.07497
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, NISCH, PTGS2, SRC 4.03666
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, PTGS2 4.03666
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 4.02817
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.99954
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CNR1, CNR2, CYP19A1, DRD1, DRD2, DYRK1A, DYRK3, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.99297
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DYRK1A, DYRK3, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.96938
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.93714
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DYRK1A, ESR1, PPARA, RORC, SRC, TOP2A 3.92105
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, IDO1, MAOA, MPO 3.87853
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, IDO1 3.87771
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK2, F3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PPARA, PTGS2, PTPN1, SRC 3.87395
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PTGS2, RORC, SRC 3.87003
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.78359
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.78359
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.78359
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CLK1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HCAR2, HMGCR, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, MPO, NISCH, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 3.73488
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, NISCH, PTGS2 3.73364
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, NISCH, PTGS2 3.73364
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, F3, FLT3, HMGCR, HTR6, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.72933
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PHF8, PPARA, SRC, TYR 3.70244
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.65888
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 3.61979
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, MAOA, TYR 3.61979
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD1, DRD2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.61369
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, PPARA, PTGS2, TBXAS1 3.5791
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.56553
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.53346
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.52762
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.49436
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.48777
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HMGCR, HTR6, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.48383
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, ESRRA, F3, FABP4, FLT3, HMGCR, HTR6, IDO1, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.4747
[BP] GO:0018210 peptidyl-threonine modification BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 3.43273
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.39839
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DYRK1A, DYRK1B, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.38289
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, ESR1 3.38289
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, HMGCR, HTR6, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.37656
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.30588
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CA3, CYP1B1, MMP9, MPO, PTGS2, SRC 3.30459
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DRD1, DRD2, DYRK1A, DYRK3, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 3.27487
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD1, DRD2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.2612
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DRD1, DRD2, DYRK1A, DYRK3, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 3.2612
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, MPO, PTGS2, SRC, TYR 3.25523
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.25456
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.25456
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HMGCR, SRC, TNKS, TNKS2 3.24408
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, PTGS2, RORC, SRC 3.23945
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.21525
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, IDO1, MAOA, MMP1, MMP12, MMP2, MMP9, MPO, SRC, XDH 3.206
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 3.20352
[BP] GO:0008217 None ADORA1, CNR1, DRD2, HSD11B2, NISCH, PPARA, PTGS2 3.16302
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, KDR, PTGS2, SRC 3.15644
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 3.10305
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.09396
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.06907
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.0651
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2 3.05703
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, HMGCR, HTR6, KDR, MET, PTGS2, PTPN1, SRC, XDH 3.05703
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PTGS2, RORC, SRC 3.05681
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, HASPIN, TNKS, TNKS2 3.05598
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, PTGS2 3.05598
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM4, CLK1, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 3.04182
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2, TBXAS1 3.02367
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, RORC, SRC 3.01189
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, MMP2, MMP9, PTGS2, SRC, TOP2A 3.00806
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.94448
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.94448
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, HMGCR, HSD11B2, MMP2, MPO, PPARA, PTGS2, SRC, TYR 2.94134
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HMGCR, MPO, PTGS2 2.93657
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, CLK1, DRD1, DYRK1A, SRC, TNKS 2.93657
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.91657
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.91657
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, ESR1, FABP4, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC 2.89963
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PHF8, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, TOP2A 2.85118
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 2.80741
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, MPO, PTGS2, SRC, TYR 2.79808
[BP] GO:0019371 None CBR1, PTGS2, TBXAS1 2.7948
[BP] GO:0010907 None DYRK2, ESRRB, PPARA, SRC 2.7948
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGS2, SRC 2.78525
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.71
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, PTGS2 2.70371
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 2.69963
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, MAOA 2.69889
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.67666
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, CLK1, DRD1, DYRK1A, SRC, TNKS 2.67262
[BP] GO:0009115 None AOX1, XDH 2.66733
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.65954
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGS2, SRC 2.60711
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4, DRD2 2.60517
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 2.60517
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.59632
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DRD1, DRD2, DYRK3, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, KDR, MET, MMP2, MMP9, PTGS2, RORC, SRC, TOP2A 2.58497
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, NISCH 2.57739
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HASPIN, HCAR2, HTR6, IGF1R, KDR, MET, MMP2, MMP9, NISCH, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2 2.53915
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.53795
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.52956
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, MET, SRC 2.51913
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.51321
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, PTGS2, RORC, SRC 2.50438
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, PHF8, PPARA, PTGS2, RORC, SRC, TNKS, TNKS2, TOP2A 2.50302
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS2 2.44103
[BP] GO:0045776 None ADORA1, CNR1, DRD2, PPARA 2.44103
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, NISCH 2.43876
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.42355
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOA 2.41395
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOA 2.41395
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, MMP9, PTGS2 2.40722
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HMGCR, HSD11B2, IDO1, MMP12, MPO, PTGS2, SRC, TYR 2.38627
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.36674
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.36674
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.36674
[BP] GO:0065007 biological regulation ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CLK1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, MPO, NISCH, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.34053
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, NISCH 2.29614
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.29279
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, PTGS2, SRC 2.28193
[BP] GO:0046110 None AOX1, XDH 2.28193
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.28193
[BP] GO:0033602 None CNR1, DRD2 2.28193
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.26728
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, PPARA, PTGS2 2.26728
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.23335
[BP] GO:0090087 None ACHE, ADORA1, CA2, CHRM1, CNR1, DRD2, DYRK2, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SRC 2.23335
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.22975
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, PTGS2, SRC 2.22029
[BP] GO:0003018 None ADORA1, CHRM1, DRD1, HMGCR, PTGS2, SRC 2.22029
[BP] GO:0010906 None DYRK2, ESRRB, PPARA, RORC, SRC 2.21475
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.21475
[BP] GO:0040013 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, NISCH 2.18673
[BP] GO:0006807 nitrogen compound metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, IDO1, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.17945
[BP] GO:0042752 None ADORA1, DRD2, PPARA, RORC, TOP2A 2.17705
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.17589
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.15557
[BP] GO:0010676 None DYRK2, ESRRB, PPARA, SRC 2.14832
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.14832
[BP] GO:0002683 negative regulation of immune system process ADORA1, AXL, CDK6, CNR1, CNR2, CYP19A1, DRD2, IDO1, MMP12 2.14832
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.13549
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.12053
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGS2 2.11984
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MPO 2.11382
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, PTPN1, RORC, SRC, TOP2A 2.08459
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, HCAR2, HMGCR, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TNKS2, XDH 2.06665
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.06665
[BP] GO:0032094 None CYP1A1, HSD11B2, MPO 2.06665
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.06665
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.05908
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.05908
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F3, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.05154
[BP] GO:0070213 None TNKS, TNKS2 2.04813
[BP] GO:0006145 None AOX1, XDH 2.04813
[BP] GO:0038171 None CNR1, CNR2 2.04813
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.04813
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, MMP12, PPARA 2.03725
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD2, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, PHF8, PPARA, RORC, SRC, TNKS, TNKS2, TOP2A 2.02926
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.02698
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.02698
[CC] GO:0043226 organelle ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CDK6, CHRM1, CLK1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, HTR6, IDO1, IGF1R, KDR, MAOA, MMP12, MMP2, MMP9, MPO, NISCH, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.91657
[CC] GO:0043227 membrane-bounded organelle ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, IGF1R, KDR, MAOA, MMP12, MMP2, MMP9, MPO, NISCH, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.62791
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK2, DYRK3, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, KDR, MAOA, MMP2, MMP9, MPO, NISCH, PIM1, PTGS2, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 2.15072
[CC] GO:0098590 plasma membrane region ABCG2, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, MET, PTGS2, SRC 2.05001
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS2, TBXAS1 1.81994
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.6286
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK2, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, TBXAS1, TNKS, TYR, XDH 16.967
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, MPO, PHF8, PIM1, PTGS2, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 15.2334
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HMGCR, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NISCH, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 13.5765
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.7468
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.7029
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MAOA, MPO, PHF8, PTGS2, TBXAS1, TYR, XDH 9.83199
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PPARA, PTPN1, RORC, TNKS 9.83199
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.58263
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 7.91837
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CLK1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 6.87501
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 6.60071
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.49439
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.49439
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC, TBXAS1 5.53854
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC, TBXAS1 5.32578
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 5.02403
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 4.96202
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B2, HSD17B1, IDO1, MPO, PTGS2, SRC, TBXAS1, XDH 4.96202
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 4.95925
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PHF8, TBXAS1, XDH 4.8584
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.71509
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.61901
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.61901
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 4.55941
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.49669
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 4.22633
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.20472
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 4.072
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PHF8, PTGS2, TBXAS1, TYR 3.99297
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.78359
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 3.65652
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 3.62333
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.30828
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.20408
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.13475
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, DRD2, HTR6 3.10403
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.07746
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.98008
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 2.96428
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.94448
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, HTR6 2.9311
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NISCH, PPARA, RORC 2.92028
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 2.91657
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.66733
[MF] GO:0003845 None HSD11B1, HSD11B2 2.66733
[MF] GO:0036094 small molecule binding ABCG2, ADORA1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, HASPIN, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, XDH 2.60401
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR6 2.58497
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.53795
[MF] GO:0042802 identical protein binding ABCG2, ACHE, AOX1, BCL2, CSNK2A1, DRD2, DYRK1A, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, NISCH, PTGS2, TOP2A, TYR, XDH 2.53792
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, SRC 2.49564
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, HASPIN, PIM1 2.4518
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET 2.44103
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET 2.44103
[MF] GO:0000166 nucleotide binding ABCG2, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, XDH 2.4282
[MF] GO:1901265 nucleoside phosphate binding ABCG2, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, XDH 2.42682
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.37958
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.34791
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SRC 2.31503
[MF] GO:0004949 None CNR1, CNR2 2.28193
[MF] GO:0043168 anion binding ABCG2, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FABP3, FABP4, FLT3, HASPIN, HMGCR, HSD17B1, IGF1R, KDR, MET, MPO, NISCH, PIM1, SRC, TOP2A, XDH 2.23923
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.23335
[MF] GO:0005524 ATP binding ABCG2, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TOP2A 2.15466
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FLT3, HASPIN, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SRC 2.11811
[MF] GO:0032559 adenyl ribonucleotide binding ABCG2, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TOP2A 2.0518
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.04813
[MF] GO:0030554 adenyl nucleotide binding ABCG2, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TOP2A 2.02926


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.0022
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.4947
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.1303
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 6.1384
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, AKR1B1, HMGCR, PTGS2, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 5.7929
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6, CHRM1, CNR2, CNR1, ADORA3, CHRM4, ADORA1, DRD1, DRD2 5.0634
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, CHRM1, ADORA1, DRD1, DRD2, PPARA 4.3309
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.4847
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.4272
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, PTGS2, MMP9, MET, IGF1R 3.2125
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 3.5774
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.5774
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.2796
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4, BCL2 2.9355
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.1431
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.4272
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, DRD2, MET, IGF1R 2.6216
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, TBXAS1, PTGS2 2.8677
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KDR, BCL2, MET, IGF1R 2.3114
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.1904
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7357
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, IGF1R 2.1483
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, MAOA, ALOX5, PTGS2 2.0772
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 1.9944
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.786
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 1.9944
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 1.9087
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.4735
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2 2.1188
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.786
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, CHRM1, DRD1 1.5385
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.786
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 1.845
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1 1.786
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, ABCG2 1.786
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 1.5947
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4 1.3144
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2 1.5786
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.5385
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.0908
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, DRD1, DRD2 1.2135
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.2869
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.031
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1, DRD2 0.9359
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.766
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.833
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.7838
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.833
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.0932
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.0267
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.833
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 0.7749
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, DRD1 1.019
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.7667
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.7442
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.7438
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.019
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9226
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.6847
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7036
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7165
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.0152
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7165
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.7165
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.0872
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.7036
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.668
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7036
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6645
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6645
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.6645
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1718
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.6047
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.5857
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5556
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2496
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.512
Purine metabolism_Homo sapiens_hsa00230 XDH 0.261
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2699
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5067
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2496
Phagosome_Homo sapiens_hsa04145 MPO 0.2948
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.301
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.2978
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3123
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3123
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3109
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3224
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3224
Axon guidance_Homo sapiens_hsa04360 MET 0.3311
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3384
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3433
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3987
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3985
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4024
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.407
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4067
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4064
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4202
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4191
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4202
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4202
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4196
Peroxisome_Homo sapiens_hsa04146 XDH 0.4307
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.467
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4451
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.467
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4655
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4752
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5388
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4769
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4897
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4897
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.4897
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4897
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4988
Shigellosis_Homo sapiens_hsa05131 SRC 0.4897
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.4903
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4897
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.513
Legionellosis_Homo sapiens_hsa05134 CLK1 0.5158
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4277
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5409
Malaria_Homo sapiens_hsa05144 MET 0.5479
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5166
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5444
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5556
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5518
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.5556
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5556
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.5933
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.5638
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.731
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.5924
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.6271
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.5924
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6645
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.668
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6459
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.668
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.6857
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6645
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.6813
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7036
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.7749
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.7165
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.766
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.833
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.8108
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.0932


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)