Prescription ID | TCMF3280 |
Pinyin Name | Gong Xue Ting Ke Li |
Chinese Name | 宫血停颗粒 |
English Name | Gong Xue Ting Granules |
Function Description | 月经过多, 崩漏 |
Indications | Menorrhagia disorder, Metrorrhagia disorder, Irregular menstruation |
Disease ICD-11 Category |
SB90 [Menorrhagia disorder (TM1), 月经过多 (TM1)
]; SB93 [Metrorrhagia disorder (TM1), 崩漏 (TM1) ]; GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ]; |
Human Tissues Associated with Indication | Uterus |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
TCMH1906 | Cimicifuga foetida | 升麻 | TCMH1906 | |
TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
TCMH2473 | Leonurus japonicus | 益母草 | TCMH2473 | ITSAN1807-14 |
TCMH1634 | Typha angustata | 蒲黄 | TCMH1634 | GBVX1726-13 |
TCMH2618 | Citrus aurantium | 枳壳 | TCMH2618 | ITSAA1279-14 |
TCMH1321 | Os draconis | 龙骨 | TCMH1321 | |
TCMH1525 | Crassostrea gigas | 牡蛎 | TCMH1525 | BCMOL364-12 |
TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
TCMH1597 | Ligustrum lucidum | 女贞子 | TCMH1597 | ITSAM2109-14 |
TCMH1503 | Eclipta prostrata | 墨旱莲 | TCMH1503 | ITSAP4516-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT139 | CA6 | Carbonic anhydrase VI | Lyase | P23280 |
TCMT140 | CA5B | Carbonic anhydrase VB | Lyase | Q9Y2D0 |
TCMT141 | CA5A | Carbonic anhydrase VA | Lyase | P35218 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
TCMT17 | POLB | DNA polymerase beta | Transferase | P06746 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT221 | ABCB11 | Bile salt export pump | Transporter | O95342 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT240 | AMY1A | Salivary alpha-amylase | Unclassified | P04745 |
TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT281 | DPP4 | Dipeptidyl peptidase IV | Unclassified | P27487 |
TCMT283 | PTPRS | Receptor-type tyrosine-protein phosphatase S | Hydrolase | Q13332 |
TCMT289 | TBXAS1 | Thromboxane-A synthase | Isomerase | P24557 |
TCMT293 | CHRM2 | Muscarinic acetylcholine receptor M2 | GPCR | P08172 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT337 | XPO1 | Exportin-1 | Unclassified | O14980 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT384 | GRK6 | G protein-coupled receptor kinase 6 | Kinase | P43250 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT44 | GLO1 | Glyoxalase I | Lyase | Q04760 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT558 | TOP2A | DNA topoisomerase II alpha | Isomerase | P11388 |
TCMT561 | NT5E | 5'-nucleotidase | Hydrolase | P21589 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT599 | UBE2N | Ubiquitin-conjugating enzyme E2 N | Transferase | P61088 |
TCMT61 | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Unclassified | Q07820 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT636 | POLA1 | DNA polymerase alpha subunit | Transferase | P09884 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT690 | HDAC3 | Histone deacetylase 3 | Hydrolase | O15379 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT718 | TXN2 | Thioredoxin, mitochondrial | Unclassified | Q99757 |
TCMT719 | TXN | Thioredoxin | Unclassified | P10599 |
TCMT734 | MMP12 | Matrix metalloproteinase 12 | Hydrolase | P39900 |
TCMT737 | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | Unclassified | Q9HC16 |
TCMT740 | PIK3CG | PI3-kinase p110-gamma subunit | Transferase | P48736 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT83 | CD38 | Lymphocyte differentiation antigen CD38 | Unclassified | P28907 |
TCMT907 | FDPS | Farnesyl diphosphate synthase | Lyase | P14324 |
Target ID | Target Name |
---|---|
TCMT1178 | Actinomyces viscosus |
TCMT1180 | Human herpesvirus 2 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1189 | Pseudomonas fluorescens |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1218 | Staphylococcus aureus |
TCMT1221 | Human herpesvirus 4 |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1227 | Streptococcus |
TCMT1229 | Enterococcus faecalis |
TCMT1231 | Human herpesvirus 1 strain KOS |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1245 | Phytophthora cactorum |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1284 | Penicillium expansum |
TCMT1286 | Bacillus cereus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1318 | Human T-lymphotropic virus 1 |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1390 | Human herpesvirus 2 strain G |
TCMT1393 | Vibrio sp. |
TCMT1408 | Colletotrichum gloeosporioides |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1444 | Fusarium oxysporum |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 12.5807 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 11.5456 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FDPS, FUT7, GLO1, PIM1, PPARA, TBXAS1, TYR, XDH | 10.7584 |
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FUT7, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 | 8.44843 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR | 8.37891 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RORC, SRC, TBXAS1, TOP2A, TYR, XDH | 7.1812 |
[BP] GO:0019369 | arachidonic acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 | 6.53675 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RORC, SRC, TBXAS1, TOP2A, TYR, XDH | 6.48731 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 | 6.33229 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 | 6.10764 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FUT7, MET, PPARA, TBXAS1 | 5.77675 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FDPS, HSD17B1, HSD17B2 | 5.60454 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA | 5.57875 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.50568 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, HCAR2, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH | 5.48232 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH | 5.42839 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, HCAR2, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH | 5.29863 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, TBXAS1 | 4.98278 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 | 4.95209 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 | 4.95209 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, POLB, PPARA, RORC, SRC, TYR | 4.95209 |
[BP] GO:0010033 | response to organic substance | AKR1B1, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, MMP2, POLB, PPARA, RORC, SRC, TYR | 4.83522 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, HCAR2, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH | 4.6673 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MCL1, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTPRS, RORC, SRC, TOP2A, TYR | 4.64141 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA | 4.50538 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC | 4.3421 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC | 4.2835 |
[BP] GO:0032787 | None | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PPARA, TBXAS1 | 4.13529 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SRC | 4.02919 |
[BP] GO:0042221 | response to chemical | AKR1B1, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, MMP2, MMP9, POLB, PPARA, RORC, SRC, TYR | 3.91671 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.49836 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 | 3.46776 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC | 3.46776 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MCL1, MET, MMP12, MMP9, PTPN1, SRC, XDH | 3.46776 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH | 3.46776 |
[BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.46776 |
[BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.46776 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MCL1, MET, MMP12, MMP9, PTPN1, SRC, XDH | 3.45842 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MCL1, MET, POLA1, POLB, PPARA, SRC, XDH | 3.41023 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SRC | 3.38108 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR | 3.3706 |
[BP] GO:0033993 | response to lipid | AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, RORC, SRC, TYR | 3.3706 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CYP1A1, FABP3, FDPS, FLT3, HCAR2, PPARA, RORC, SRC | 3.3706 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 | 3.35648 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, POLB, PPARA, PTPRS, SRC, TYR | 3.29214 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC | 3.20873 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.0184 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MCL1, MMP2, MMP9, POLA1, POLB, PTPN1, RORC, SRC, TOP2A | 2.99063 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR | 2.95886 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RORC, SRC, TBXAS1, TOP2A, TYR, XDH | 2.91613 |
[BP] GO:0006082 | organic acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR | 2.8925 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, MMP12, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TOP2A, TYR | 2.8925 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.70278 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, XDH | 2.69123 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, MCL1, MET, POLA1, POLB, SRC | 2.65323 |
[BP] GO:0006286 | base-excision repair, base-free sugar-phosphate removal | APEX1, POLB | 2.63363 |
[BP] GO:0014070 | response to organic cyclic compound | APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, RORC, SRC, TYR | 2.63141 |
[BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RORC, SRC, TBXAS1, TOP2A, TYR, XDH | 2.56523 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC | 2.4676 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 | 2.40346 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC | 2.38956 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH | 2.38494 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS | 2.38494 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RORC, SRC, TBXAS1, TOP2A, TYR, XDH | 2.37525 |
[BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, APEX1, AXL, CYP1B1, SRC | 2.37479 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1, HSD17B2 | 2.35006 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.34661 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.31641 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC | 2.28391 |
[BP] GO:0009725 | response to hormone | AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, SRC | 2.27703 |
[BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC | 2.2657 |
[BP] GO:0009636 | response to toxic substance | AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, KDR, POLB, SRC | 2.26269 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, AXL, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, KDR, MCL1, MMP9, PIM1, POLB, PPARA, PTPRS, RORC, SRC, TYR | 2.2622 |
[BP] GO:0098502 | DNA dephosphorylation | APEX1, POLB | 2.2553 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.2553 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC | 2.21611 |
[BP] GO:0097237 | cellular response to toxic substance | AKR1B1, APEX1, AXL, CYP1B1, KDR | 2.21468 |
[BP] GO:0070301 | cellular response to hydrogen peroxide | AKR1B1, APEX1, AXL, CYP1B1 | 2.17692 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD17B1, HSD17B2 | 2.17692 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, XDH | 2.15997 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS | 2.14934 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, FDPS, HSD17B1, HSD17B2 | 2.13661 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, APEX1, AURKB, AXL, CDC25B, CSNK2A1, FDPS, FLT3, IGF1R, KDR, MET, PIM1, POLB, PTPN1, PTPRS, SRC, XDH | 2.09827 |
[BP] GO:0030574 | collagen catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.08704 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.08703 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.03369 |
[BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.01363 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.01363 |
[BP] GO:0042180 | None | AKR1B1, AKR1B10, CYP19A1, GLO1 | 2.00325 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, KDR, MCL1, MMP2, MMP9, PIM1, POLA1, PTPN1, PTPRS, SRC, TBXAS1, TOP2A, TYR, XDH | 2.19049 |
[CC] GO:0097443 | sorting endosome | KDR, PTPN1 | 1.67215 |
[CC] GO:0099055 | None | ADORA1, PTPRS | 1.41323 |
[CC] GO:0099699 | None | ADORA1, PTPRS | 1.41323 |
[CC] GO:0099240 | None | ADORA1, PTPRS | 1.41323 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 17.7703 |
[MF] GO:0046914 | transition metal ion binding | ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TBXAS1, TYR, XDH | 15.5158 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, PTPRS, SRC, TBXAS1, TOP2A, TYR, XDH | 13.8002 |
[MF] GO:0016835 | carbon-oxygen lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB | 13.7063 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 11.5992 |
[MF] GO:0016829 | lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB | 10.7396 |
[MF] GO:0043167 | ion binding | ACHE, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RORC, SRC, TBXAS1, TOP2A, TYR, XDH | 10.5196 |
[MF] GO:0043169 | cation binding | ACHE, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, TBXAS1, TOP2A, TYR, XDH | 7.17127 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 6.76225 |
[MF] GO:0046872 | metal ion binding | ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, TBXAS1, TOP2A, TYR, XDH | 6.76225 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC | 6.76225 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH | 6.51394 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR | 6.38525 |
[MF] GO:0005506 | iron ion binding | ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH | 6.00004 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 | 5.48803 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 | 5.34723 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 | 5.29863 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR | 4.95209 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, POLA1, SRC, TBXAS1, XDH | 4.10842 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 | 3.99413 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.38108 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A | 3.25301 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6 | 3.00568 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH | 2.99903 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, FLT3, IGF1R, KDR, MET | 2.94101 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC | 2.79729 |
[MF] GO:0008389 | None | CYP2A13, CYP2A6 | 2.63363 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.38526 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC | 2.32688 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 | 2.22397 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 | 19.3707 |
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R | 8.1903 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 6.1825 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 | 5.6981 |
Metabolic pathways_Homo sapiens_hsa01100 | FDPS, CBR1, AKR1B1, TYR, CYP19A1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, XDH | 5.3079 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 | 5.4905 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.4477 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | SRC, MMP2, KDR, MMP9, MET, IGF1R | 3.4977 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9 | 4.1005 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.2826 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | PIM1, CYP1B1, MMP9, MET, CDC25B, MCL1 | 2.7007 |
Pathways in cancer_Homo sapiens_hsa05200 | FLT3, MMP1, MMP2, MMP9, MET, IGF1R | 2.1258 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 2.7007 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5, TBXAS1 | 2.1775 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1 | 2.1476 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CHRM2, KDR, MET, MCL1, IGF1R | 1.7775 |
cAMP signaling pathway_Homo sapiens_hsa04024 | CHRM2, HCAR2, ADORA1, PPARA | 1.7775 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 1.8857 |
Focal adhesion_Homo sapiens_hsa04510 | SRC, KDR, MET, IGF1R | 1.7775 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | SRC, KDR, MET, IGF1R | 1.768 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | SRC, MMP2, MMP9 | 1.7775 |
Endocytosis_Homo sapiens_hsa04144 | SRC, KDR, MET, IGF1R | 1.5391 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 5.3363 |
Ras signaling pathway_Homo sapiens_hsa04014 | KDR, MET, IGF1R | 1.0649 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, ADORA1 | 1.3368 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3363 |
VEGF signaling pathway_Homo sapiens_hsa04370 | SRC, KDR | 1.3072 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | FLT3, MET | 1.2435 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.3215 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, PIM1 | 1.0031 |
Melanoma_Homo sapiens_hsa05218 | MET, IGF1R | 1.232 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET | 1.2435 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2 | 1.0649 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | CDC25B, IGF1R | 1.0166 |
Cholinergic synapse_Homo sapiens_hsa04725 | CHRM2, ACHE | 0.9547 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET | 0.9547 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, CYP1A2 | 1.2435 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.167 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PPARA | 0.9547 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | CHRM2, ADORA3, ADORA1 | 0.9259 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, XDH | 1.4865 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 1.8726 |
Platelet activation_Homo sapiens_hsa04611 | SRC, TBXAS1 | 0.9219 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, MMP9 | 0.9259 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.768 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | ADORA3, ADORA1 | 0.9255 |
Hepatitis B_Homo sapiens_hsa05161 | SRC, MMP9 | 0.8099 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.8365 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIM1, MCL1 | 0.7749 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | ADORA3, ADORA1 | 0.757 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.6631 |
Purine metabolism_Homo sapiens_hsa00230 | POLA1, XDH | 0.7328 |
Viral carcinogenesis_Homo sapiens_hsa05203 | POLB, SRC | 0.6507 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.7303 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | CHRM2, SRC | 0.6271 |
Base excision repair_Homo sapiens_hsa03410 | POLB, APEX1 | 1.721 |
HTLV-I infection_Homo sapiens_hsa05166 | POLB, FDPS | 0.5479 |
MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.2795 |
ErbB signaling pathway_Homo sapiens_hsa04012 | SRC | 0.4935 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1 | 0.3476 |
Prostate cancer_Homo sapiens_hsa05215 | IGF1R | 0.4935 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.4935 |
Calcium signaling pathway_Homo sapiens_hsa04020 | CHRM2 | 0.3741 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3689 |
TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.4697 |
Influenza A_Homo sapiens_hsa05164 | FDPS | 0.3759 |
Tuberculosis_Homo sapiens_hsa05152 | SRC | 0.3741 |
Apoptosis_Homo sapiens_hsa04210 | MCL1 | 0.436 |
Gap junction_Homo sapiens_hsa04540 | SRC | 0.4935 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | SRC | 0.4897 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.4878 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.4935 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | IGF1R | 0.4928 |
Measles_Homo sapiens_hsa05162 | CSNK2A1 | 0.436 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.452 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.4935 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | IGF1R | 0.4851 |
FoxO signaling pathway_Homo sapiens_hsa04068 | IGF1R | 0.4393 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | IGF1R | 0.5479 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PPARA | 0.4185 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.4878 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1 | 0.436 |
AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.452 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | SRC | 0.4572 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | SRC | 0.4067 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | SRC | 0.3689 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | IGF1R | 0.436 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.4935 |
Hepatitis C_Homo sapiens_hsa05160 | PPARA | 0.4393 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.4935 |
Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.436 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | SRC | 0.5309 |
Cell cycle_Homo sapiens_hsa04110 | CDC25B | 0.452 |
Serotonergic synapse_Homo sapiens_hsa04726 | ALOX5 | 0.4675 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1 | 0.4928 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.4928 |
Toxoplasmosis_Homo sapiens_hsa05145 | ALOX5 | 0.4572 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.4476 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.4935 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.5258 |
Glioma_Homo sapiens_hsa05214 | IGF1R | 0.5479 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.4928 |
Long-term depression_Homo sapiens_hsa04730 | IGF1R | 0.5479 |
Pyrimidine metabolism_Homo sapiens_hsa00240 | POLA1 | 0.4824 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.5479 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5309 |
Renal cell carcinoma_Homo sapiens_hsa05211 | MET | 0.5478 |
Bile secretion_Homo sapiens_hsa04976 | CA2 | 0.5309 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | RORC | 0.5479 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.5479 |
Malaria_Homo sapiens_hsa05144 | MET | 0.6173 |
Pyruvate metabolism_Homo sapiens_hsa00620 | GLO1 | 0.6796 |
Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.7206 |
DNA replication_Homo sapiens_hsa03030 | POLA1 | 0.716 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2 | 0.7615 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.7565 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.783 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.757 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.7755 |
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | FDPS | 0.8365 |