TCM Prescription: Fu Fang Ban Xia Tablets



Prescription Description
Prescription IDTCMF3237
Pinyin NameFu Fang Ban Xia Pian
Chinese Name复方半夏片
English NameFu Fang Ban Xia Tablets
Function Description咳嗽
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH98 Cynanchum stauntonii 白前 TCMH98 GQ434571
TCMH1223 Tussilago farfara 款冬花 TCMH1223 ITSAH4326-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, MET, MIF, PPARA 10.259
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.38765
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.01546
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD17B1, HSD17B2, KDR, MET, MIF, PPARA, SLC1A1, SRC, TERT, XDH 7.9297
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HMGCR, MIF, PIM1, PPARA, TYR, XDH 7.77091
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, GRM1, HMGCR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 7.31901
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, GRM1, HMGCR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 7.31901
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FUT7, HMGCR, MET, MIF, PPARA 7.20765
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.99604
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 6.58007
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HMGCR, HSD17B1, HSD17B2 6.57623
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 6.49512
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 6.21276
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SRC, TYR 6.21276
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 6.05992
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP3, FLT3, HMGCR, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, SRC, TERT, XDH 6.05992
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC, TERT 6.03716
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.02222
[BP] GO:0010033 response to organic substance AKR1B1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PPARA, SRC, TYR 6.01889
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, GRM1, HMGCR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 5.94081
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 5.94081
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 5.94081
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 5.83182
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, APP, CDC25B, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 5.70262
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AXL, CYP1B1, EGFR, ERBB2, FLT3, GRM1, HMGCR, KDR, MET, MIF, PTPN1, SRC, XDH 5.70262
[BP] GO:0042221 response to chemical AKR1B1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, SRC, TERT, TYR 5.68895
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, APP, CDC25B, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 5.67366
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.60015
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC, TERT 5.59814
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP2, MMP9, PTPN1, SRC 5.49278
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 5.46302
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 5.40932
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.31527
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC, TERT, XDH 5.28798
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APP, AXL, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC, TERT 5.28798
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, GRIK5, GRM5, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT 5.25961
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, FABP3, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 5.23454
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, APP, CDC25B, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PTPN1, SRC, XDH 5.09551
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, APP, CDC25B, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PTPN1, SRC, XDH 5.09551
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA 5.07992
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SRC, TERT, XDH 5.04263
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 5.04263
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 5.01474
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HMGCR, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC, TERT 4.96541
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, XDH 4.88728
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, ERBB2, FLT3, GRM1, HMGCR, KDR, MIF, PTPN1, SRC, XDH 4.87509
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PTPN1, SRC, XDH 4.8524
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, HMGCR, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TERT 4.8042
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 4.75341
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HMGCR, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC, TERT, XDH 4.73149
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HMGCR, IGF1R, MIF, PTPN1, SRC 4.61738
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.60921
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, MIF, PTPN1, SRC 4.60601
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.5463
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.49879
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PTPN1, SRC, XDH 4.48436
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, TERT 4.46725
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 4.42819
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC 4.30885
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, APP, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EGFR, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TYR 4.3036
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PTPN1, SRC, XDH 4.29222
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, MIF, PTPN1, SRC 4.29222
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, EGFR, ERBB2, FLT3, GRM1, HMGCR, IGF1R, KDR, MIF, PTPN1, SRC, XDH 4.29222
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, GRM1, HMGCR, MMP2, PPARA, SRC, TERT, TYR 4.22783
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.21731
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, SRC, TERT 4.20532
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MIF, MMP2, MMP9, PTPN1, SRC, TERT 4.18778
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, MIF, PTPN1, SRC 4.18619
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 4.17908
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, GRIK5, GRM5, HMGCR, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT 4.15477
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MIF, MMP9, PPARA, PTPN1, SRC, XDH 4.14711
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, HMGCR, HSD17B1, HSD17B2 4.10791
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 4.10791
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 4.10765
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, CA2, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, FUT7, HMGCR, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, SRC, TERT, TYR 4.09001
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD17B1, HSD17B2, TYR, XDH 4.08796
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 4.01132
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, TYR 4.01115
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, APP, AURKB, CDC25B, CSNK2A1, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MIF, MMP9, PTPN1, SRC, TERT, XDH 4.00813
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MIF, MMP9, PTPN1, SRC, XDH 4.00466
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, MIF, PTPN1, SRC 4.00466
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 4.0024
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.89971
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.80988
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.75304
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.75304
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.75304
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.75304
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.68626
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, MIF, PTPN1, SRC 3.61927
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TYR, XDH 3.61927
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.58213
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, SRC, TYR 3.57556
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, EGFR, HMGCR, KDR, MIF, SRC 3.56287
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.56246
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 3.5436
[BP] GO:0032787 None ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA 3.54046
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, EGFR, ERBB2, HMGCR, KDR, MIF, PTPN1, SRC 3.52839
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR 3.43714
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PTPN1, SRC, XDH 3.40857
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, TERT 3.39646
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HMGCR, IGF1R, MIF, PTPN1, SRC 3.38636
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AXL, CYP1A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, SRC 3.38266
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 3.34496
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, MIF, PTPN1, SRC 3.31748
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.31748
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.31748
[BP] GO:0042391 None ADORA1, APP, CACNA1C, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.31748
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 3.28826
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.26883
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 3.2522
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ERBB2, FLT3, MET, MIF, PIM1, SRC, TYR 3.24896
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 3.21759
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF 3.14784
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, EGFR, ERBB2, HMGCR, MIF, MMP12, PTPN1, SRC 3.14338
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.14026
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.14026
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, EGFR, FABP4, HMGCR, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH 3.14026
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, TERT 3.13877
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, MIF, PTPN1, SRC 3.12858
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, APP, AXL, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC 3.1016
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, MIF, PTPN1, SRC 3.09291
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SRC, TERT, TYR, XDH 3.06524
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, APP, AURKB, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 3.01565
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.01565
[BP] GO:0007188 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.99838
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, TYR 2.94046
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, APP, AXL, CA2, CYP1B1, EGFR, HMGCR, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC1A1, SRC, TERT 2.91386
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, PIM1, PPARA, PTPN1, SRC, TERT, TYR, XDH 2.8856
[BP] GO:0014070 response to organic cyclic compound APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, SRC, TYR 2.88523
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, MIF, PTPN1, SRC 2.88169
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRB1, APP, AURKB, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, MET, MIF, MMP9, PTPN1, SRC, TERT, XDH 2.84967
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.81854
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.81584
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.79694
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, APP, AURKB, CDC25B, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.777
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.777
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, MIF, PTPN1, SRC 2.77582
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.76392
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, EGFR, GRIK5, GRM5, IGF1R, MMP2, MMP9, SRC 2.75846
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, APP, AURKB, CDC25B, CSNK2A1, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.75846
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, EGFR, MIF, SRC, TERT 2.73581
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TYR 2.72722
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, ERBB2, PPARA 2.70982
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, AURKB, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, MIF, PTPN1, SRC, TERT, XDH 2.70982
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.70651
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.70518
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.70518
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, APP, AXL, CA2, CACNA1C, CYP1B1, EGFR, ERBB2, GRM1, HMGCR, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC1A1, SRC, TERT, XDH 2.69556
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.69038
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.67855
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.67524
[BP] GO:0007187 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.67316
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 2.66813
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, EGFR, ERBB2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.59171
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, TYR 2.59093
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13 2.58812
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, EGFR, ERBB2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.58812
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.58812
[BP] GO:0099566 None GRM1, GRM5 2.56909
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.56909
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.56909
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, PPARA, SRC 2.56238
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, EGFR, ERBB2, MIF, MMP12, SRC, TERT 2.55097
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 2.55097
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, EGFR, ERBB2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.54693
[BP] GO:0006082 organic acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, TYR 2.54693
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, EGFR, HMGCR, KDR, MIF, SRC 2.54582
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TYR 2.50088
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.50088
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, HMGCR, TYR 2.48326
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.47898
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.47813
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CYP19A1, EGFR, GRIK5, HMGCR, MIF, MMP12, SRC 2.46434
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.4384
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC 2.43338
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.43115
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.43115
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.42717
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.42717
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2, MIF 2.42288
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, MET, SRC, XDH 2.4094
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.39294
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.3914
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.37097
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.36322
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.34632
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 2.34142
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.33643
[BP] GO:0032880 regulation of protein localization ACHE, APP, CACNA1C, CSNK2A1, EGFR, ERBB2, HMGCR, MIF, MMP12, PTPN1, SRC, TERT 2.33643
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.33643
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33643
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, IGF1R, KDR, MET, MMP9, SRC, TERT 2.32666
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.31305
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.31305
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, EGFR, HMGCR, MIF, MMP12, SRC 2.26356
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CYP19A1, EGFR, GRIK5, HMGCR, MIF, MMP12, SRC 2.24339
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, KDR, SRC 2.23644
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 2.23644
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, IGF1R, KDR, MET, MMP9, SRC, TERT 2.23173
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.22841
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.21747
[BP] GO:0061097 None ADORA1, APP, GRM5, PTPN1 2.20848
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, MMP9, SRC 2.19052
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.19052
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.16795
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, IGF1R, KDR, MET, MMP9, SRC, TERT 2.1583
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.15576
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.15138
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, PPARA, SRC 2.15138
[BP] GO:0006793 phosphorus metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 2.13222
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.11172
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, MET, SRC 2.11044
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.10138
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.10138
[BP] GO:1904645 response to amyloid-beta APP, GRM5, IGF1R 2.10138
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.0797
[BP] GO:0051234 None ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, EGFR, FABP3, GRIA2, GRIA4, GRIK5, MIF, MMP12, MMP9, PPARA, SLC1A1, SRC, TERT, XDH 2.0797
[BP] GO:0003018 None ADORA1, ADRB1, EGFR, HMGCR, SRC 2.07961
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, IGF1R, KDR, MET, MMP9, SRC, TERT 2.07323
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.06717
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HMGCR, PPARA, SRC 2.0665
[BP] GO:0051223 None ACHE, APP, CACNA1C, EGFR, ERBB2, HMGCR, MIF, MMP12, PTPN1, SRC 2.05661
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, FABP4, HMGCR, KDR, MET, MIF, MMP12, PPARA 2.05354
[BP] GO:0002793 None ACHE, ADORA1, EGFR, MIF, MMP12, SRC 2.03573
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.03508
[BP] GO:1901989 None APP, CDC25B, CYP1A1, TERT 2.03508
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, SRC, TYR 2.01147
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SRC, TERT 2.0112
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.0112
[BP] GO:0042058 None ADORA1, APP, EGFR, MMP9 2.00836
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.00836
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 5.01836
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TERT 4.36422
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRB1, APP, AXL, CA2, CA4, CA9, CACNA1C, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SRC 4.10765
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TERT, TYR 3.87173
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 3.71696
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.63499
[CC] GO:0014069 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 3.42933
[CC] GO:0099572 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 3.42933
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRB1, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, KDR, MET, PTPN1, SLC1A1, SRC, TYR 3.31748
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, CA4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 3.12858
[CC] GO:0043235 receptor complex APP, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, IGF1R 3.11693
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 2.75846
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.64174
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.58174
[CC] GO:0044432 endoplasmic reticulum part APP, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, GRIA2, HMGCR, HSD17B2, PTPN1 2.58174
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.54582
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.51447
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, APP, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, HMGCR, HSD17B1, HSD17B2, KDR, MIF, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TYR, XDH 2.24942
[CC] GO:0098794 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.11044
[CC] GO:0005783 None ADORA1, APP, CA4, CES2, CYP19A1, FLT3, GRIK5, HMGCR, KDR, PTPN1, XDH 2.06407
[CC] GO:0043005 None ADORA1, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.01577
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.0112
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.92829
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TYR, XDH 9.80381
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.19865
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TYR, XDH 7.88843
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.67053
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.42474
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 6.13289
[MF] GO:0043167 ion binding ACHE, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SRC, TERT, TYR, XDH 6.13289
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.70473
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.6074
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.42721
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.16464
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.96541
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD17B1, HSD17B2, TYR, XDH 4.96457
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.61253
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA 4.60601
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET 4.46334
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET 4.46334
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.46259
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.28175
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.2107
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.01345
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA 4.00466
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA 3.82006
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.59431
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD17B1, SRC, XDH 3.5148
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA 3.47452
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.43481
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 3.43367
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.29795
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2, XDH 3.27689
[MF] GO:0043169 cation binding ACHE, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, TERT, TYR, XDH 3.26883
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 3.2522
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1 3.14607
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 3.04566
[MF] GO:0046872 metal ion binding ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, TERT, TYR, XDH 3.00205
[MF] GO:0008389 None CYP2A13, CYP2A6 2.94046
[MF] GO:0019902 phosphatase binding EGFR, ERBB2, HMGCR, MET, PPARA, PTPN1 2.8856
[MF] GO:0042802 identical protein binding ACHE, APP, CSNK2A1, EGFR, ERBB2, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MIF, MMP9, TERT, TYR, XDH 2.66426
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.66426
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.63494
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.59171
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.58812
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.58812
[MF] GO:0099583 None GRM1, GRM5 2.56909
[MF] GO:0019903 protein phosphatase binding EGFR, ERBB2, HMGCR, MET, PTPN1 2.54582
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2 2.53007
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TERT 2.39019
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.36374
[MF] GO:0004971 None GRIA2, GRIA4 2.33643
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.06717
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R 2.01659
[MF] GO:0004064 arylesterase activity CA1, CA2 2.0112


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.4401
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 8.4895
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.2393
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 7.2232
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 7.2232
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, ADRB1, GRM1, GRIA4 6.7433
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, EGFR, IGF1R 5.6057
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.4317
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.4637
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, ERBB2, MMP9, MET, EGFR, IGF1R 3.7387
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1, EGFR 3.9252
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, ERBB2, ADRB1, CACNA1C, GRM1, EGFR 3.8526
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, GRM1, GRIA4 3.9151
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, ADRB1, GRM1, EGFR 4.1412
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.2547
MicroRNAs in cancer_Homo sapiens_hsa05206 ERBB2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.6855
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, ADRB1, CACNA1C, PPARA, GRIA4 3.6855
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, MET, EGFR, IGF1R 3.6724
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, TYR, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 3.495
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1, EGFR 3.4078
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 3.193
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 3.5158
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.5113
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 3.0844
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.495
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, EGFR, IGF1R 2.7158
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 2.2419
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.5432
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.4695
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, CACNA1C, GRIA4 2.37
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1344
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.4015
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.3217
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3638
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.3952
Prostate cancer_Homo sapiens_hsa05215 ERBB2, EGFR, IGF1R 2.0963
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 2.1137
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, EGFR, IGF1R 1.8652
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 2.0263
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.9311
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2 2.7657
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, EGFR, IGF1R 1.9435
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, CACNA1C 1.8652
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.6826
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, CACNA1C, GRIA4 1.739
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, EGFR, IGF1R 1.7109
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.5396
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, EGFR, IGF1R 1.3957
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 1.1086
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.1444
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1621
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CACNA1C 1.088
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0964
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9219
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 1.2761
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.044
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9763
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, CACNA1C 0.9169
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0462
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 1.0248
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6851
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.2237
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9535
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.2355
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.4345
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.8526
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3198
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2711
Pancreatic cancer_Homo sapiens_hsa05212 ERBB2, EGFR 1.429
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4796
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3396
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.338
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3687
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3586
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3511
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.5281
Tuberculosis_Homo sapiens_hsa05152 SRC 0.368
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.521
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3582
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.3995
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4018
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.5745
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4141
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4323
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4375
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4331
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4323
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.3897
Platelet activation_Homo sapiens_hsa04611 SRC 0.4637
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4862
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4678
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4637
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4637
Axon guidance_Homo sapiens_hsa04360 MET 0.4584
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.4651
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4678
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5144
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4999
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5144
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5147
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5144
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.519
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5239
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5236
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5188
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.5239
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5239
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5187
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5193
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5239
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5258
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5318
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5602
Peroxisome_Homo sapiens_hsa04146 XDH 0.5308
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5239
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5421
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5583
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5308
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5669
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5583
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5855
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.6162
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5885
Shigellosis_Homo sapiens_hsa05131 SRC 0.587
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5965
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.7535
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.67
Malaria_Homo sapiens_hsa05144 MET 0.6813
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6851
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9435
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.8492
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.4167
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8979
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8345
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1207
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8526
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8972
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8726
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9027
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8972
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9535
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.044


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)