TCM Prescription: Geng Nian Ning



Prescription Description
Prescription IDTCMF3207
Pinyin NameGeng Nian Ning
Chinese Name更年宁
English NameGeng Nian Ning
Function Description眩晕, 不寐, 月经失调, 绝经前后诸症
IndicationsMenopausal disorder, Vertigo disorder, Insomnia disorder, Climacteric states
Disease ICD-11 Category SB95 [Menopausal disorder (TM1), 绝经前后诸症 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
GA30.00 [Menopausal or female climacteric states, 更年期或女性更年期状态 ];
Human Tissues Associated with IndicationBrain, Uterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH552 Rhizoma pinelliae preparata 法半夏 TCMH552
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2161 Vaccaria segetalis 王不留行 TCMH2161
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F2, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KCNH2, KDR, MAOA, MCL1, MET, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS1, PTGS2, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 14.13
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.2056
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.2056
[BP] GO:0042221 response to chemical ABCB1, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, CA2, CA3, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MMP2, MMP9, PIK3CA, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP1, TYR 12.7389
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, FUT7, GLO1, HMGCR, HSD17B3, HSPA1A, PIK3CA, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, TYR, XDH 12.7389
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGES, PTGS1, PTGS2 12.3666
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGES, PTGS1, PTGS2 12.1642
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, HSD17B3, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 12.1122
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.8294
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGES, PTGS1, PTGS2 11.8294
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, F10, F2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.5884
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.5554
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AR, AXL, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TEK, TYR 11.483
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, EGFR, F10, F2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TEK, XDH 11.483
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, PIK3CA, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 11.4824
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.4169
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.2192
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F2, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTAFR, PTGES, PTGS1, PTGS2, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.7298
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGES, PTGS1, PTGS2 9.62459
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F2, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.59857
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.48683
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 9.48368
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGES, PTGS1, PTGS2 9.46683
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TEK, XDH 9.40821
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.35713
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, CA2, CA3, CA6, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, F2, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MCL1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TYR 9.33957
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, ESR1, HMGCR, HSD17B1, HSD17B2, HSD17B3 9.29067
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 9.26122
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PPARA, PTGES, PTGS1, PTGS2 9.20458
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MCL1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.02551
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 8.94037
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 8.90993
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 8.62553
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, PTAFR, PTGS2, RELA, RORC, SLC6A4, SMAD3, SRC, TERT 8.5004
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, PTGS2, RELA, SLC6A4, SMAD3, SRC, TEK 8.45024
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F2, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, INSR, KCNH2, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTAFR, PTGS2, RELA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TNKS2, TOP1, TYR 8.36594
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AR, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, F3, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MET, MMP12, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 8.35474
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 8.25614
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, ESRRB, F2, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.12341
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, ESRRB, F2, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.12341
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.09331
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, PTAFR, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TEK, TYR 8.07968
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, PTAFR, PTGS2, RELA, SLC6A4, SRC, TEK 8.05857
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.02853
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HMGCR, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 7.85449
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MCL1, MMP2, MMP9, NUAK1, PIK3CA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A 7.82723
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, NQO2, PTGS1, RORC 7.70504
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADRA2A, APP, CYP19A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, HMGCR, HSPA1A, IGF1R, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, RELA, SMAD3, SRC, TEK, TERT, XDH 7.41495
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT 7.39162
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PTAFR, PTGES, PTGS2, RELA, RORC, SLC6A4, SRC, TYR 7.39162
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT 7.36235
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.35465
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGES, PTGS2, RELA, SRC, TERT 7.33881
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, PIK3CA, PTAFR, PTGS2, RELA, RORC, SLC6A4, SMAD3, SRC 7.27023
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GLO1, PPARA, PTGES, PTGS1, PTGS2 7.1039
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, ESRRB, F2, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.0572
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.99944
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 6.99944
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.97191
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MCL1, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 6.89656
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, RELA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.87227
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, PIK3CA, PPARA, PTPRS, RELA, SMAD3, SRC, TEK, TYR 6.86617
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT 6.86617
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA3, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 6.86194
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, F2, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.76298
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, AR, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, TEK, XDH 6.72621
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, CDC25B, CSNK2A1, EGFR, ESR1, F2, F3, FLT3, HMGCR, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, PTGS2, RELA, TEK, TERT 6.59787
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.55142
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.55142
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F2, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, PTPRS, RELA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.51815
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, CSNK2A1, EGFR, ESR1, F2, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 6.49307
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5, PTAFR 6.47679
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.43859
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CACNA1C, CBR1, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR 6.41433
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTAFR, PTGS2, RELA, RORC, SLC6A4, SRC 6.41072
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA3, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 6.40115
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MAP3K7, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, RELA, SMAD3, SRC, TEK, TNKS, TNKS2 6.39503
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA2A, APP, AR, AURKB, CDC25B, EGFR, ESR1, ESR2, F2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TNKS, XDH 6.37814
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, APP, AR, AXL, CA2, CACNA1C, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F2, F3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIM1, PTAFR, PTGS2, PTPRS, RELA, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH 6.33836
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, ALOX15, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, EGFR, F2, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, INSR, KCNH2, MAP2K1, MMP12, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT 6.32981
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, APP, AR, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 6.28749
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, APP, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.26155
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA2A, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, F2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TERT, TNKS, XDH 6.244
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KCNH2, KDR, MAP2K1, MCL1, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.19042
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, AR, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, TEK, XDH 6.06242
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 6.05563
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.03683
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 5.99676
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, APP, CACNA1C, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 5.9081
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, CA3, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, KCNH2, KDR, PTAFR, PTGS2, RELA, SLC6A2, SLC6A4, SRC, TOP1 5.90421
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, ESR1, F2, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.90421
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 5.8441
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, APP, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 5.83102
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 5.77561
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 5.68362
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 5.66693
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.65545
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, CACNA1C, EGFR, F2, HCAR2, HMGCR, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 5.64925
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 5.6441
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KCNH2, KDR, MAP2K1, MCL1, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.6342
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTAFR, PTGS2, RORC, SLC6A4, SRC 5.6341
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.6341
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 5.55864
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.54862
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, F2, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3 5.54311
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2, SLC6A4 5.52836
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2, SLC6A4 5.52836
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 5.52078
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, APP, AR, AXL, CA2, CYP1B1, EGFR, ESRRB, F2, F3, HCAR2, HMGCR, HSPA1A, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, PTAFR, PTGS2, RELA, SLC1A1, SMAD3, SRC, TEK, TERT 5.34355
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, APP, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 5.30826
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.27999
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.27999
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.26887
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TEK, XDH 5.20311
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 5.19072
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, AR, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, RELA, SLC6A4, SMAD3, SRC, TERT, XDH 5.10426
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, AR, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, RELA, SLC6A4, SMAD3, SRC, TERT, XDH 5.08092
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, AR, CYP19A1, DUSP3, EGFR, ESR1, ESR2, F2, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, RELA, SMAD3, SRC, TEK, TERT, XDH 5.07042
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, APP, AR, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, PTAFR, PTGS2, RELA, SLC6A4, SMAD3, SRC 5.03323
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, EGFR, F2, FLT3, GRM1, GRM5, INSR, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 5.01693
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, EGFR, F2, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.98583
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS, TOP1 4.98583
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CA3, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, RELA, SRC 4.93001
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 4.9264
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, EGFR, F2, FLT3, GRM1, GRM5, INSR, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.89991
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, APP, AURKB, CDC25B, EGFR, ESR1, F2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTAFR, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.88525
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AXL, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 4.85678
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2, HSD17B3, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 4.85651
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 4.83021
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 4.81993
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.79533
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 4.75995
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, APP, AR, AURKB, CSNK2A1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MAP2K1, MCL1, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 4.68921
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, F2, FABP3, FLT3, HCAR2, HMGCR, PPARA, PTGS2, RORC, SRC, TEK 4.68181
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 4.62012
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 4.61082
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 4.61082
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.59263
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, F2, HSPA1A, MAP2K1, MAP3K7, MCL1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A 4.58924
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3 4.57466
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, GRM1, HMGCR, HSPA1A, MMP2, PPARA, PTAFR, PTGS2, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 4.54101
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 4.52662
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, MAOA, PTGS2, SLC1A1, SLC6A2, SLC6A4, SMAD3 4.52615
[BP] GO:0003018 None ADORA1, ADRA2A, EGFR, HMGCR, PTAFR, PTGS2, SLC6A4, SRC, TEK 4.49469
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 4.47063
[BP] GO:0019371 None CBR1, PTGES, PTGS1, PTGS2 4.42403
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, PTGS2, RELA, SLC6A4, SRC, TEK, TYR 4.42237
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTAFR, PTGES, PTGS2, RELA, SLC6A4, SRC 4.41764
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, GRM1, INSR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 4.39645
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 4.31777
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, PTAFR, PTGS2, RELA, SLC6A4, SRC 4.31443
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, F2, F3, FABP4, HMGCR, KDR, MAP2K1, MET, MMP12, PPARA, PTGS2, PTPRS, RELA, SMAD3, TEK 4.24976
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 4.23851
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CA3, CES1, CYP1A1, CYP1B1, HMGCR, KDR, RELA, SLC6A4, SRC 4.23474
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, HSPA1A, MAP3K7, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, RELA, SMAD3, SRC, TEK 4.22425
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CYP19A1, EGFR, F2, HCAR2, INSR, KCNH2, MMP12, PTAFR, PTGS2, SLC6A4, SMAD3, SRC, TERT 4.22387
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 4.21191
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS, TOP1 4.21148
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR, HMGCR 4.18507
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KCNH2, KDR, PTAFR, PTGS2, RELA, SRC 4.14508
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 4.13792
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, F2, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.13051
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 4.12092
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CES1, CYP19A1, CYP1A1, CYP1B1, HMGCR, HSD17B3, MAOA, PTAFR, TYR 4.12025
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, PTGS2, RELA, SRC, TEK 4.09579
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.07969
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTAFR, PTGS2, RELA, SLC6A4, TEK, TYR 4.07969
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MAP2K1, MAP3K7, MCL1, MET, NUAK1, PTGS2, PTPN1, PTPRS, TERT, XDH 4.03022
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.01125
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, PTGS2, RELA, SLC6A4, SRC, TEK, TYR 4.00325
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.99456
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FLT3, HSD17B2, HSD17B3, INSR, KDR, MAP2K1, MCL1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TYR 3.99456
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, PTAFR, PTGS2, RELA, SLC6A4, SRC 3.9804
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MAP3K7, MCL1, MET, PIK3CA, PIK3CB, PPARA, PTPN1, RELA, SMAD3 3.97638
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, XDH 3.97026
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 3.96192
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 3.94002
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, MAP2K1, PIK3CA, RELA, SMAD3, TYR 3.8997
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 3.86079
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 3.84499
[BP] GO:0070920 None EGFR, ESR1, MAP2K1, TERT 3.78398
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 3.78005
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, EGFR, GRM1, INSR, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 3.74553
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTAFR, PTGS2, RELA, SLC6A4, TEK, TYR 3.73668
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, EGFR, HSPA1A, MAOA 3.73525
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADRA2A, APP, CA2, CA7, CACNA1C, F2, GPR35, GRM5, KCNH2, MMP9, PTAFR, PTGS2, SLC6A4 3.71913
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGES, PTGS1, PTGS2 3.71251
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGES, PTGS2, TERT 3.6918
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 3.65822
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 3.63767
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, F2, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, SRC, TEK, TNKS, TOP1, TOP2A 3.6371
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 3.61434
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, HSD17B3 3.61176
[BP] GO:0003013 None ADORA1, ADRA2A, EGFR, HMGCR, PTAFR, PTGS2, SLC6A4, SRC, TEK 3.60924
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, EGFR, HCAR2, MCL1, MET, PIK3CA, PPARA, RELA, SMAD3 3.60924
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, PTAFR, PTGS2, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.59709
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 3.55426
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, RELA, SMAD3, SRC, TERT, XDH 3.52364
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, RELA, SRC, TERT 3.51538
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.51165
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, HMGCR, KDR, MAP2K1, PTPN1, SRC, TEK 3.46293
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 3.45387
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, SLC1A1, SLC6A2, SLC6A4 3.44268
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 3.44138
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CES1, CYP19A1, HMGCR, HSD17B3, PTAFR, TYR 3.44138
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DUSP3, EGFR, ESR1, F10, F2, F3, FLT3, FUT7, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 3.41572
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, APP, AR, AURKB, CSNK2A1, CYP2D6, DUSP3, ESR1, ESR2, ESRRA, F2, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.41546
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, EGFR, FLT3, PTAFR, PTGS2, RELA, SRC 3.39863
[BP] GO:0007193 None ADORA1, ADRA2A, GRM1, GRM3, GRM5, GRM8 3.39353
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, CYP1A1, EGFR, ESR1, FLT3, MAP2K1, MET, PIK3CB, PIM1, SRC, TEK, TYR 3.38046
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.35354
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3, TERT, TNKS, TOP2A 3.34516
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC, TOP1, TOP2A 3.34516
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, GRM1, INSR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 3.3415
[BP] GO:0040016 embryonic cleavage PIK3CB, TOP1, TOP2A 3.29656
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, PTAFR, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.28404
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, F2, FABP3, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 3.27512
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 3.26321
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, PTGS2, SRC, TEK 3.26128
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.24928
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 3.24427
[BP] GO:0097746 None ADORA1, ADRA2A, EGFR, HMGCR, PTAFR, PTGS2, SLC6A4 3.24427
[BP] GO:0035296 None ADORA1, ADRA2A, EGFR, HMGCR, PTAFR, PTGS2, SLC6A4 3.24427
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, F2, PIK3CA, PIK3CB, PTAFR, PTGES, PTGS1, PTGS2, RELA 3.23093
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5, PTAFR 3.23093
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, RELA, TYR 3.23093
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HMGCR, HSD17B1, HSD17B2, HSD17B3 3.2046
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, MAP2K1, MMP2, MMP9, PTAFR, PTGS2, SLC6A4, SRC, TOP2A 3.20439
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, HMGCR, HSD17B3, PTAFR, PTGES, PTGS1, PTGS2 3.19596
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 3.19252
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, PTAFR, RELA, SRC 3.18406
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, MAP2K1, PTGS2, SRC 3.18296
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, CACNA1C, EGFR, GPR35, GRM1, HCAR2, KCNH2, PTAFR, PTGS2, SLC1A1, SMAD3 3.17908
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 3.17415
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, F2, PPARA, SMAD3 3.17219
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT 3.14963
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.13293
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, F2, PTGS2, SMAD3, SRC, TERT 3.13219
[BP] GO:0050880 None ADORA1, ADRA2A, EGFR, HMGCR, PTAFR, PTGS2, SLC6A4 3.09127
[BP] GO:0035150 None ADORA1, ADRA2A, EGFR, HMGCR, PTAFR, PTGS2, SLC6A4 3.07127
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.06781
[BP] GO:0010676 None ESRRB, INSR, PPARA, PTAFR, SRC 3.06449
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 3.0472
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, INSR, PTGS2, SMAD3, XDH 3.02791
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 3.00859
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.00851
[BP] GO:0006693 None CES2, PTGES, PTGS1, PTGS2 3.00851
[BP] GO:0006692 None CES2, PTGES, PTGS1, PTGS2 3.00851
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, PTGS2, RELA, SMAD3, TEK 2.99224
[BP] GO:0010359 None ABCB1, GRM5, PTAFR 2.98056
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, HMGCR, PTGS2, RELA, SLC6A4, TYR 2.96416
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, CACNA1C, CYP1B1, EGFR, GRM5, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MCL1, MET, NUAK1, PIK3CA, PIK3CB, PTAFR, PTPN1, RELA, SRC, TEK 2.94505
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, CA2, CYP19A1, DUSP3, ESR1, ESRRA, F2, HCAR2, HSPA1A, MAP3K7, MMP12, MMP2, PIK3CA, PIK3CB, PTAFR, PTPN1, PTPRS, RELA, SMAD3, SRC 2.94187
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SRC 2.91386
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, HMGCR, KDR, MAP2K1, SRC, TEK 2.90932
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, F2, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 2.89188
[BP] GO:0051591 None APEX1, APP, PTAFR, RELA, TEK, TYR 2.89188
[BP] GO:0042391 None ADORA1, APP, CACNA1C, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC 2.88741
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 2.88274
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, PTAFR, PTGS2, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.84832
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGES, PTGS1, PTGS2 2.83767
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 2.83071
[BP] GO:0040008 regulation of growth APP, AR, CSNK2A1, EGFR, ESR2, F2, HSPA1A, INSR, PIK3CA, PIM1, PTPRS, SLC6A4, SMAD3, TNKS2 2.81972
[BP] GO:0051172 None ADRA2A, APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.81606
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.81374
[BP] GO:0008217 None ADORA1, AR, PPARA, PTAFR, PTGS1, PTGS2, SMAD3 2.79619
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, MAP2K1, SRC 2.77211
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA 2.76886
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2, HSD17B3 2.76886
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, INSR, RELA, SRC 2.75954
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, HSPA1A, MCL1, RELA, SRC, TERT 2.73742
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 2.73525
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, XDH 2.73158
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.72798
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.6981
[BP] GO:0009115 None AOX1, XDH 2.69121
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TERT, TNKS, TOP2A 2.65547
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.65547
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, PTPN1, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.64458
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, XDH 2.64458
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.64458
[BP] GO:1902893 None PPARA, RELA, SMAD3, TERT 2.64458
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.64458
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA, SRC 2.64457
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.64009
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.63153
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.62828
[BP] GO:0071396 cellular response to lipid AR, AXL, EGFR, ESR1, FLT3, PTAFR, RELA, RORC, SLC6A4, SRC 2.62565
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, CACNA1C, EGFR, KCNH2, PTAFR, PTGS2, SLC1A1 2.62471
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F2, F3, HMGCR, INSR, KDR, MAP2K1, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RELA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH 2.61512
[BP] GO:0030168 platelet activation ADRA2A, AXL, F2, PIK3CA, PIK3CB, SRC 2.60804
[BP] GO:0045913 None ESRRB, INSR, PPARA, PTAFR, SRC 2.57693
[BP] GO:0019725 cellular homeostasis APEX1, APP, CA2, CA7, CACNA1C, ESR1, F2, GPR35, GRIK5, GRM1, GRM5, MCL1, PIK3CA, PIK3CB, SMAD3 2.57693
[BP] GO:0034762 None ABCB1, ADRA2A, APP, CA2, CACNA1C, F2, GPR35, GRM5, KCNH2, MMP9, PTAFR 2.57298
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, F3, GRIK5, HCAR2, HMGCR, MCL1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.56287
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.53719
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.53719
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.53719
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2C19, CYP2D6, MAOA 2.53719
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 2.53719
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, HSPA1A, MAP2K1, PTGES, PTGS2, SLC6A4, SMAD3, TERT, XDH 2.53215
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, F3, GRIK5, HCAR2, HMGCR, MCL1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.53201
[BP] GO:1903034 regulation of response to wounding ADRA2A, F2, F3, HMGCR, MAP2K1, PTPRS, SMAD3 2.52357
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, F2, PPARA, SMAD3, TEK 2.52161
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, F2, INSR, PTGS2, SMAD3, XDH 2.50949
[BP] GO:0001817 regulation of cytokine production ADRA2A, AXL, CYP1B1, F2, HSPA1A, MAP3K7, MMP12, PTAFR, PTGS2, PTPRS, RELA, SMAD3, SRC 2.50179
[BP] GO:0050730 None ADORA1, ADRA2A, APP, EGFR, FLT3, GRM5, PTPN1, SRC 2.49751
[BP] GO:0007568 aging APEX1, AURKB, CYP1A1, HMGCR, MAP2K1, PTGS2, RELA, TERT 2.49751
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.48386
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, F2, MMP12, PPARA, SMAD3, TEK 2.48386
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.46896
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.45003
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, CACNA1C, EGFR, F2, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.44816
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.443
[BP] GO:0055080 cation homeostasis APP, CA2, CA7, CACNA1C, EGFR, ESR1, F2, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 2.44226
[BP] GO:0061097 None ADORA1, ADRA2A, APP, GRM5, PTPN1 2.43424
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA 2.43386
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, RELA, SMAD3, SRC, TERT 2.42117
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.41704
[BP] GO:0010675 None ESRRB, INSR, PPARA, PTAFR, RORC, SRC 2.41704
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, CBR1, CDC25B, CES1, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MAP2K1, MCL1, MET, MMP2, MMP9, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A 2.41126
[BP] GO:0097756 None ADORA1, HMGCR, PTGS2, SLC6A4 2.40768
[BP] GO:1903798 None EGFR, ESR1, MAP2K1 2.37011
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.37011
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2, SLC6A4 2.36638
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, MAP3K7, PIM1, RELA 2.36638
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.36546
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.34925
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.33073
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.33073
[BP] GO:0001819 positive regulation of cytokine production ADRA2A, CYP1B1, HSPA1A, MAP3K7, MMP12, PTAFR, PTGS2, RELA, SMAD3, SRC 2.30862
[BP] GO:0055082 cellular chemical homeostasis APP, CA2, CA7, CACNA1C, ESR1, F2, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, SMAD3 2.30657
[BP] GO:1901570 None ALOX15, ALOX5, PTGES, PTGS1, PTGS2 2.30657
[BP] GO:1901224 None APP, EGFR, MAP3K7, RELA 2.30657
[BP] GO:0099566 None GRM1, GRM5 2.30657
[BP] GO:0033590 None EGFR, RELA 2.30657
[BP] GO:0046110 None AOX1, XDH 2.30657
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.30657
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.30657
[BP] GO:0002520 None CACNA1C, SMAD3 2.30657
[BP] GO:2000811 negative regulation of anoikis MCL1, PIK3CA, SRC 2.30657
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.30657
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.30657
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.27217
[BP] GO:0061098 None ADORA1, ADRA2A, GRM5, PTPN1 2.27217
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, CSNK2A1, EGFR, ESR1, ESR2, F2, GRIK5, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, MMP1, MMP9, PIK3CB, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.264
[BP] GO:0010942 positive regulation of cell death CYP1B1, F3, GRIK5, HCAR2, HMGCR, MCL1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.264
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, EGFR, F10, F2, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KCNH2, MCL1, MMP12, MMP9, PPARA, PTAFR, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, XDH 2.2636
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.23792
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A4 2.23792
[BP] GO:0001775 cell activation ADRA2A, ALOX5, APP, AXL, EGFR, F2, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, PTAFR, RORC, SMAD3, SRC 2.23106
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.22388
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, EGFR, ESR1, F10, F2, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KCNH2, MCL1, MMP12, MMP9, PPARA, PTAFR, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 2.22289
[BP] GO:0030155 regulation of cell adhesion ALOX15, CYP1B1, DUSP3, KDR, MAP3K7, NUAK1, PIK3CA, PIK3CB, PPARA, PTAFR, SMAD3, SRC, TEK 2.22289
[BP] GO:0042058 None ADORA1, ADRA2A, APP, EGFR, MMP9 2.18125
[BP] GO:0072507 divalent inorganic cation homeostasis APP, CACNA1C, EGFR, ESR1, F2, GPR35, GRM1, GRM5, PIK3CB, SMAD3 2.15135
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CACNA1C, CYP19A1, EGFR, GRIK5, HCAR2, HMGCR, MMP12, PTAFR, SLC6A4, SRC 2.14994
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, APEX1, AR, EGFR, ESR1, FLT3, INSR, RELA, SRC 2.11494
[BP] GO:0060341 regulation of cellular localization ADRA2A, APP, AR, CACNA1C, CSNK2A1, EGFR, F2, GRIK5, HMGCR, MAP2K1, PTGS2, PTPN1, SMAD3, SRC, TERT 2.11494
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, GPR35, KCNH2, MMP9, PTGS2 2.11315
[BP] GO:0034765 None ABCB1, ADRA2A, APP, CACNA1C, F2, GPR35, GRM5, KCNH2, MMP9, PTAFR 2.09125
[BP] GO:0050890 None ADORA1, APP, EGFR, GRM5, HMGCR, INSR, PTGS2, SLC6A4 2.08626
[BP] GO:0000187 activation of MAPK activity GRM1, INSR, MAP2K1, MAP3K7, PIK3CB, PTPN1 2.08447
[BP] GO:0045934 None ADRA2A, APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 2.08352
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.07344
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.07344
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, F2, F3, HMGCR, INSR, KDR, MAP2K1, PIM1, PTGS2, PTPRS, RELA, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.0726
[BP] GO:0032845 None ADORA1, ADRA2A, HMGCR, SRC, TNKS, TNKS2 2.0726
[BP] GO:0023052 None ADORA1, AR, CACNA1C, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, KCNH2, SLC1A1, SLC6A2, TEK 2.06427
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.06413
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 2.06365
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, CYP1A1, EGFR, HMGCR, PTGS2, RELA, SLC6A4, SRC, TYR 2.06161
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.06161
[BP] GO:0070213 None TNKS, TNKS2 2.06161
[BP] GO:0006145 None AOX1, XDH 2.06161
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.06161
[BP] GO:1901529 None ABCB1, PTAFR 2.06161
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.06161
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.06161
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 2.05502
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, F2, KDR, SRC 2.05452
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PTGS2, RELA, SRC, TEK 2.04615
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, F2, HMGCR, PPARA, PTPRS, SMAD3, TEK 2.03819
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F2, F3, FABP4, KDR, MET, PTGS2, SMAD3 2.03819
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.01605
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.00934
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.00934
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.00934
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.00934
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.00781
[BP] GO:1903959 None ABCB1, GRM5, PTAFR 2.00781
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.00369
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.00357
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ESR1, F10, F2, F3, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 6.33836
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALOX5, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, ESR1, F10, F2, F3, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HSD17B3, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR 5.85156
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA2A, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, DUSP3, EGFR, F10, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KCNH2, KDR, MET, PTAFR, PTGS2, PTPRS, SLC1A1, SLC6A2, SLC6A4, SRC, TEK 5.21548
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CACNA1C, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, SLC6A4, SMAD3, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 4.49469
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, F10, F2, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HSD17B3, IGF1R, INSR, KCNH2, KDR, MAOA, MCL1, MET, PIK3CA, PIK3CB, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A4, SRC, TEK, TYR 4.18147
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, APP, AXL, CA4, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, PTPRS, SLC1A1, SLC6A2, SLC6A4, TEK 4.13792
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, PTGS2, SLC1A1, SRC, TEK 4.13792
[CC] GO:0044432 endoplasmic reticulum part APP, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, F10, F2, FLT3, GRIA2, HMGCR, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, PTPN1 4.00679
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SHBG, SLC1A1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 3.52364
[CC] GO:0005783 None ADORA1, APEX1, APP, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GRIK5, HMGCR, HSD17B3, HSPA1A, KDR, MAP2K1, PTGS2, PTPN1, XDH 3.26321
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.13219
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HMGCR, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SHBG, SLC1A1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 3.06368
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, APP, AXL, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, PTPRS, SLC1A1, SLC6A2, SLC6A4, TEK 2.99759
[CC] GO:0043235 receptor complex ADRA2A, APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 2.94095
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 2.73742
[CC] GO:0009330 None TOP1, TOP2A 2.69121
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SLC6A4, SRC 2.57298
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.54327
[CC] GO:0043005 None ADORA1, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SLC6A2, SLC6A4, SRC, TUBB3 2.54147
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.53077
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, GRIA2, HMGCR, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2 2.40768
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK 2.29761
[CC] GO:0097458 None ADORA1, APP, CA2, CACNA1C, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, PTGS1, PTGS2, PTPRS, SLC6A2, SLC6A4, SRC, TOP1, TUBB3 2.19593
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA7, CA9, CACNA1C, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MET, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 2.15429
[CC] GO:0014069 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 2.15429
[CC] GO:0099572 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 2.15429
[CC] GO:0031233 None CA4, F10, F3 2.06161
[CC] GO:0098589 membrane region APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.04322
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 18.4679
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 17.7038
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 17.6388
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, F10, F2, F3, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 15.5694
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8899
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8899
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HMGCR, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 9.49631
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F2, GLO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.47215
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3, TNKS 9.40821
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F2, GLO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.35713
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, TEK 8.0411
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.76046
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, PPARA, PTAFR, RORC, SMAD3, TEK 7.66755
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.43575
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, XDH 7.35479
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.35465
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 7.23673
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 6.91903
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, TEK 6.8855
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PTAFR, RORC, TEK 6.59121
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SRC, TEK, TOP1, TOP2A 6.46594
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TYR 6.46594
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HMGCR, HSD17B1, NQO2, PTGES, PTGS1, PTGS2, SRC, XDH 6.31489
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.30183
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.23276
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, TYR 6.12445
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6 5.91506
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.68203
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.68203
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.55864
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F2, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTAFR, PTGES, PTPRS, RELA, SLC1A1, SRC, TEK, TOP1, TOP2A, TUBB3, XDH 5.47985
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NQO2, SHBG 5.3301
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC, SHBG 5.29579
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TOP1 5.29311
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 5.26887
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.19072
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD17B1, HSD17B2, HSD17B3, XDH 4.92419
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 4.91287
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 4.86532
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, HSD17B1, PPARA, PTAFR, RORC, SHBG 4.44132
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.42403
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, CSNK2A1, EGFR, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KCNH2, KDR, MAP3K7, MCL1, MET, MMP9, NQO2, PTGS2, RELA, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 4.37639
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 4.33938
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SLC6A4, SMAD3, SRC 4.18514
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SLC6A4, SMAD3, SRC 4.08618
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT, TOP1 3.95004
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, HSPA1A, KCNH2, MET, PPARA, PTAFR, PTGS2, PTPN1, RELA, SLC6A4, SMAD3, SRC, TEK, TNKS2, TOP2A 3.92812
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PTAFR, TEK 3.69428
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PTAFR, TEK 3.69428
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, HSD17B3 3.34516
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, FLT3, HMGCR, KCNH2, MCL1, NQO2, PTGS2, RELA, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 3.05649
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 2.98056
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SLC1A1, SRC, TEK, TOP1, TOP2A, TUBB3, XDH 2.93379
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RELA, RORC, SHBG, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 2.92148
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AR, AXL, EGFR, FLT3, HMGCR, KCNH2, MCL1, NQO2, PTGS2, RELA, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 2.723
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.69121
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.69121
[MF] GO:0008389 None CYP2A13, CYP2A6 2.69121
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.64457
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A, TUBB3, XDH 2.56282
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A, TUBB3, XDH 2.56074
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F2, F3, FLT3, IGF1R, INSR, KCNH2, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SRC, TEK, TOP1 2.49488
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, MAP2K1, MAP3K7, SMAD3 2.40146
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A 2.32065
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.30657
[MF] GO:0005330 None SLC6A2, SLC6A4 2.30657
[MF] GO:0099583 None GRM1, GRM5 2.30657
[MF] GO:0047374 None CES1, CES2 2.30657
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTAFR, PTPRS, SRC, TEK, TOP1, TOP2A, TUBB3 2.28817
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, PTAFR, PTPN1, RELA, SMAD3, SRC, TOP2A 2.27217
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CA3, CDC25B, CES1, CES2, DUSP3, MAP2K1, PTPN1, PTPRS 2.26938
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.23792
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.23792
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.23792
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, GRM5, PTAFR, PTPN1, RELA, SMAD3, SRC, TOP2A 2.22526
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A 2.21431
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ADRA2A, AOX1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SLC6A4, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TUBB3, XDH 2.2081
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, TOP2A 2.17809
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.1068
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.1068
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.06161
[MF] GO:0004971 None GRIA2, GRIA4 2.06161
[MF] GO:0032795 None ADORA1, ADRA2A 2.06161
[MF] GO:0051425 None APP, INSR 2.06161
[MF] GO:0005497 None AR, SHBG 2.06161
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.06161
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F2, F3, MMP1, MMP12, MMP2, MMP9 2.00369


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.6678
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.3007
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 9.3007
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, CYP2D6, ALOX5, ALOX15, CACNA1C, PTGS2, CYP2C19, PTGS1, SLC6A4 8.8321
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MAP3K7, MET, EGFR, IGF1R 7.945
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GPR35, GRIK5, PTAFR, F2, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 6.8233
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 6.4214
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 6.4214
Pathways in cancer_Homo sapiens_hsa05200 MAP2K1, SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, RELA, IGF1R, AR, PIK3CA, MET 6.1598
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, HSD17B3, AKR1B1, HMGCR, PTGS2, TYR, CYP2C19, CYP19A1, PTGS1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES, CES1 6.0798
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.3194
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 6.4214
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, CYP2C19, PTGES, PTGS1 6.1188
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, MAP2K1, PIK3CA, INSR, GRM8, PIK3CB, GRM1, EGFR 5.9052
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 6.252
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, PIK3CA, INSR, TEK, PIK3CB, EGFR, RELA, IGF1R 5.9052
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, MAP2K1, PIK3CA, ADORA1, CACNA1C, PIK3CB, PPARA, RELA, GRIA4 5.8019
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, ESR2, RELA 5.8035
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.5872
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, RELA, IGF1R 5.3152
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9, EGFR 5.9052
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 5.8019
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, PIK3CA, PIK3CB, EGFR, RELA, IGF1R 5.2735
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, ABCB1, PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B, MCL1 5.2174
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, PIM1, PIK3CB, F3, RELA 4.9855
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 5.2264
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, PIM1, PIK3CB, RELA 5.2283
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, RELA, MCL1, IGF1R 4.7762
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.1025
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 4.8233
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, INSR, ADORA1, CACNA1C, PIK3CB, ADRA2A 4.654
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, SMAD3, PIK3CA, PIK3CB, EGFR, RELA 4.9442
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, PIK3CB, MET, EGFR 4.9197
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, MET, EGFR, IGF1R 4.08
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SMAD3, PIK3CA, SRC, PIK3CB, MMP9, RELA 4.08
Melanoma_Homo sapiens_hsa05218 MAP2K1, PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.8233
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2, AOX1, CYP2C19 4.8576
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2, EGFR 3.8901
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, PTGS2, GRM1, GRIA4 4.0036
Gap junction_Homo sapiens_hsa04540 GRM5, MAP2K1, SRC, TUBB3, GRM1, EGFR 4.3142
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA, RELA 3.8611
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, DUSP3, CACNA1C, MAP3K7, EGFR, RELA, CDC25B, HSPA1A 3.4719
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB, MAP3K7, RELA, HSPA1A 3.6811
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, PIK3CA, ADORA3, ADORA1, PIK3CB, RELA 3.6584
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA, HSPA1A 3.3825
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, HMGCR, MAP3K7, IGF1R 3.5875
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 3.8901
Glioma_Homo sapiens_hsa05214 MAP2K1, PIK3CA, PIK3CB, EGFR, IGF1R 3.8739
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 3.304
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, SMAD3, PIK3CA, PIK3CB, RELA 3.6674
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, MAP2K1, CACNA1C, GRM1 3.8611
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, PIK3CA, SRC, PIK3CB, EGFR 3.3543
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C, EGFR 3.2856
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PIK3CB, CDC25B, IGF1R 3.1639
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, RELA, IGF1R 3.2343
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, PIK3CA, CACNA1C, PIK3CB 2.9481
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.0262
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.0577
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.8233
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.8047
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA, HSPA1A 2.6469
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1 2.8508
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 2.6714
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, PIK3CA, SRC, PIK3CB, F2, EGFR 2.543
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR, RELA 2.6621
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, PIK3CB, RELA, MCL1 2.5894
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.1803
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2011
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2094
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1, PIK3CA, INSR, PIK3CB 2.5981
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.232
Phagosome_Homo sapiens_hsa04145 TUBB3 0.232
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA, RELA 2.4642
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.267
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, AOX1, PIK3CB, MCL1 2.3876
Axon guidance_Homo sapiens_hsa04360 MET 0.2805
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, CACNA1C, GRM1, EGFR 2.1665
Influenza A_Homo sapiens_hsa05164 MAP2K1, PIK3CA, PIK3CB, RELA, HSPA1A 2.2096
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.1665
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3497
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PIK3CA, SRC, PIK3CB, RELA 2.1006
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.512
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.5113
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.365
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3639
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.5399
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.377
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB, RELA 1.5884
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.3786
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6428
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.3783
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.387
Salmonella infection_Homo sapiens_hsa05132 RELA 0.3839
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.3783
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.0264
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3783
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.3854
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, PIK3CA, PIK3CB, EGFR 2.2836
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 0.9241
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB, RELA 1.3476
Peroxisome_Homo sapiens_hsa04146 XDH 0.3887
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PIK3CA, PIK3CB, RELA 2.0474
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB, RELA 2.2423
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.0582
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.392
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.3887
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7084
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PIK3CA, PIK3CB, RELA 2.7328
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, CACNA1C, GRIA4 1.95
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4025
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.0688
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 2.857
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, CACNA1C, PIK3CB 1.1278
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4045
Pertussis_Homo sapiens_hsa05133 RELA 0.4112
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1, PIK3CA, PIK3CB 1.2055
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.7222
Long-term depression_Homo sapiens_hsa04730 GRIA2, MAP2K1, GRM1, IGF1R 2.9897
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, MAP3K7 1.1651
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4133
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, PIK3CA, PIK3CB, EGFR 3.0848
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4133
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.2965
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, CACNA1C, GRIA4 2.8444
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2, MAP3K7, RELA 2.4047
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, PIK3CA, PIK3CB, EGFR 3.1957
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 0.8359
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, SMAD3, PIK3CA, PIK3CB 2.9481
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.8758
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.6469
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.8477
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2, RELA 2.5201
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1, PIK3CA, PIK3CB 1.5786
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9034
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.5337
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.4599
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.5578
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, RELA 1.5143
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR, RELA 2.8321
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.9169
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 0.9543
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8139
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, CACNA1C, PIK3CB 3.3017
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5063
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA, RELA 3.2818
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5103
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.3543
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.0701
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2, F3 1.7493
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.0625
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 1.8389
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5306
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PIK3CB 1.9115
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.0701
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5354
Malaria_Homo sapiens_hsa05144 MET 0.5399
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR 1.8681
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5479
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5426
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.1278
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.1206
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.1693
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5702
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC, RELA 1.957
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.2026
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1789
Legionellosis_Homo sapiens_hsa05134 RELA, HSPA1A 1.2237
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6043
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6043
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7111
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.3697
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6931
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6712
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7111
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.5251
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4617
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.743
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7033
Prion diseases_Homo sapiens_hsa05020 MAP2K1, HSPA1A 1.5563
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.731
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6647
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1, EGFR 1.7491
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6149
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP2C19 2.8336
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.6421
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7726
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5369
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8049
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9017
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8684
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9666
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9594
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2771


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)