TCM Prescription: Chen Xiang Qu



Prescription Description
Prescription IDTCMF3179
Pinyin NameChen Xiang Qu
Chinese Name沉香曲
English NameChen Xiang Qu
Function Description腹胀, 胁痛
IndicationsHypochondrium pain disorder, Hepatitis
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
DB97.Z [Inflammatory liver disease, unspecified, 某些特指的炎症性肝病,未特指的 ];
Human Tissues Associated with IndicationIntestine, Stomach, Liver
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH512 Fructus amomi rotundus 豆蔻 TCMH512
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH702 Fructus setariae germinatus 谷芽 TCMH702
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH2066 Santalum album 檀香 TCMH2066 ITSAJ4584-14
TCMH1068 Dalbergia odorifera 降香 TCMH1068 ITSAJ4189-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1310 Enterococcus hirae
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MET, MIF, POLA1, POLB, PPARA, PTGS2, SLC1A1, SRC, TERT, TNKS, TNKS2, XDH 12.2744
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, MPO, POLB, PPARA, PTGES, PTGS2, RELA, SRC, TYR 12.0706
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MET, MIF, PPARA, PTGES, PTGS2, TBXAS1 11.2534
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 10.7614
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, MPO, PTGES, PTGS2, RELA, SRC, TYR 10.5814
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GBA2, HMGCR, HSD17B3, IDO1, MIF, MPO, PIM1, PPARA, PTGES, PTGS2, TBXAS1, TYR, XDH 10.3909
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, MPO, POLB, PPARA, PTGES, PTGS2, RELA, SRC, TYR 9.23157
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, MPO, POLB, PPARA, PTGES, PTGS2, RELA, SRC, TERT, TOP1, TYR 9.20375
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, MPO, PTGS2, TBXAS1, TYR, XDH 8.81212
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, GRM1, HCAR2, HMGCR, HTR6, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 8.81212
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, GRM1, HCAR2, HMGCR, HTR6, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 8.78763
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, PTGS2, TBXAS1 8.69157
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.4539
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, PTGS2, TBXAS1 8.39664
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, MAP2K1, MIF, MMP12, MMP2, MMP9, PIM1, PTGES, PTGS2, RELA, SRC, TERT, XDH 8.30089
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, MPO, PIM1, PTGS2, PTPN1, RELA, SRC, TERT, XDH 7.63863
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 7.59493
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, XDH 7.58393
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.48276
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 7.4776
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAP2K1, MIF, MMP9, MPO, PIM1, PTGS2, PTPN1, RELA, SRC, TERT, XDH 7.13617
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, GRM1, HMGCR, HTR6, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 7.08804
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.08258
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS2, TBXAS1 6.82861
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, PTGS2, TBXAS1 6.7341
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, F10, F3, FLT3, GRM1, HMGCR, HTR6, KDR, MAP2K1, MAP3K7, MET, MIF, PTGS2, PTPN1, RELA, SRC, XDH 6.73201
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, PTGES, PTGS2, RELA, SRC, TYR 6.67547
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, GRM1, HMGCR, HTR6, IDO1, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 6.63972
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.60758
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.49826
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 6.40222
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGES, PTGS2, RELA, SRC, TERT 6.33391
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, RELA, SRC, TNKS2, TOP1, TYR 6.33391
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HTR6, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 6.32658
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IDO1, IGF1R, KDR, MET, MIF, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TERT 6.31025
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP12, MMP2, MMP9, MPO, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TERT, TOP1, TYR 6.28496
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IDO1, IGF1R, KDR, MET, MIF, MMP9, MPO, PIM1, PTGS2, PTPN1, RELA, SRC, TERT 6.27032
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, MIF, PPARA, PTGES, PTGS2, TBXAS1 6.24564
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, CNR1, HCAR2, HMGCR, KDR, MIF, PTGS2, SRC, TNKS, TNKS2 6.24564
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HMGCR, MAP2K1, MIF, MPO, POLB, PTGS2, RELA, TERT 6.21338
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, GRM1, GRM3, GRM5, GRM8, HTR6 6.18734
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, RELA, TERT 6.17411
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.15819
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, POLB, PPARA, RELA, SRC, TYR 6.06027
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGES, PTGS2, TBXAS1 6.06027
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.98814
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 5.98814
[BP] GO:0042493 response to drug ABCG2, AKR1B1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HMGCR, HSD11B2, KDR, POLB, PTGS2, RELA, SRC, TOP1 5.98814
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 5.97688
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4, GRM1, GRM3, GRM5, GRM8 5.91636
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IDO1, IGF1R, KDR, MIF, MMP9, MPO, PIM1, PTGS2, PTPN1, RELA, SRC, TERT 5.7373
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HTR6, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, SLC1A1, SRC, TERT, TNKS, TNKS2, XDH 5.49605
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, MPO, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 5.48231
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC 5.48231
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGES, PTGS2, RELA, SRC 5.4657
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.4657
[BP] GO:0032787 None ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, MIF, PPARA, PTGES, PTGS2, TBXAS1 5.44233
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP2, MMP9, PIM1, POLB, PPARA, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2 5.37684
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, GRM1, GRM3, GRM5, GRM8, PTGS2 5.37684
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, SRC 5.37684
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GBA2, HMGCR, HSD17B3, MAOA, TYR 5.37618
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.25984
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, PTGS2, RELA, SRC 5.22761
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGES, PTGS2, RELA, SRC 5.19079
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, HMGCR, IDO1, IGF1R, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, XDH 5.11369
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, MET, MIF, MMP2, MMP9, MPO, PIM1, POLB, PPARA, PTGS2, RELA, SRC, TERT, TNKS2, TYR 5.08881
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS2, TBXAS1 5.0816
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, GRM1, HMGCR, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 5.08014
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, GRM1, HCAR2, HMGCR, IDO1, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIM1, PTGS2, RELA, SLC1A1, SRC, TERT, TNKS2, XDH 5.0502
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.92706
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, F10, F3, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KDR, MAP2K1, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT 4.87752
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC, TERT 4.82521
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.81621
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HCAR2, HMGCR, IDO1, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIM1, PTGS2, RELA, SLC1A1, SRC, TERT 4.75803
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, GRM1, GRM3, GRM5, GRM8 4.75803
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 4.7325
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MIF, PTGES, PTGS2 4.7325
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HMGCR, KDR, POLB, RELA, SRC 4.7142
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, MAP2K1, MET, MIF, PIM1, POLA1, SRC, TYR 4.56739
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, POLA1, POLB, SRC, TERT 4.51203
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, IDO1, MAOA, MMP1, MMP12, MMP2, MMP9, MPO, SRC, XDH 4.49677
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP2, MMP9, POLA1, POLB, PTGS2, PTPN1, RELA, SRC, TERT 4.42533
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, MIF, MPO, PIM1, PPARA, PTGES, PTGS2, TBXAS1, TYR 4.3641
[BP] GO:0007154 None ADORA1, AR, AXL, BCL2, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, PTGS2, SLC1A1 4.35607
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 4.30948
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 4.30948
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 4.29915
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MAP2K1, MET, MIF, MMP12, PPARA, PTGS2, RELA 4.29915
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FLT3, GRM1, GRM5, HMGCR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 4.229
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC, TERT 4.20541
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CHRM4, CSNK2A1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MAP3K7, MET, MIF, MMP2, MMP9, PTPN1, RELA, SRC, TNKS, TNKS2 4.20541
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 4.18286
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 4.18286
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, GRM1, HMGCR, HSD11B2, MMP2, MPO, POLB, PPARA, PTGS2, RELA, SRC, TERT, TYR 4.15279
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.11965
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.10482
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GRM1, HMGCR, HTR6, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 4.09215
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.06313
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC, TERT 4.04653
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.98603
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, PTGS2, RELA, SRC, TERT 3.95385
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.90325
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.90325
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, MIF, MPO, PIM1, PPARA, PTGES, PTGS2, TBXAS1, TYR 3.89298
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CDK6, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HTR6, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, RELA, SLC1A1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 3.8599
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.85389
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.85115
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, MIF, PIM1, PPARA, PTGES, PTGS2, TBXAS1, TYR 3.8316
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MIF, MMP9, PTGS2, PTPN1, RELA, SRC, TERT 3.82803
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.79114
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, HSD17B3, IDO1 3.79025
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, MMP9, PIM1, POLB, PPARA, PTGS2, RELA, SRC, TYR 3.77874
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC, TERT 3.77646
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MAP2K1, MAP3K7, MIF, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 3.75155
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, PTGS2, RELA, SRC 3.71953
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, GRM1, HMGCR, KDR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, XDH 3.71953
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, MPO, PTGS2, RELA, SRC, TYR 3.69729
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2A6, CYP3A4, MAOA, MPO 3.68288
[BP] GO:0023052 None ADORA1, AR, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 3.64447
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD17B3, IDO1, MIF, MPO, PTGES, PTGS2 3.63507
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PTGS2, SRC, TERT 3.62838
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, PTGS2, RELA, SRC 3.62629
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 3.62252
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 3.62252
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, IDO1, MAOA, MPO 3.5879
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2, TERT 3.58258
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGES, PTGS2, RELA, SRC 3.55844
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.54314
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, IDO1, MAP2K1, MMP2, MMP9, PTGS2, SRC 3.51276
[BP] GO:0007267 None ADORA1, AR, CHRM1, CHRM2, CHRM4, CNR1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR6, SLC1A1 3.51276
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 3.5105
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HMGCR, IDO1, IGF1R, KDR, MAP2K1, MET, MIF, MMP12, MMP9, MPO, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 3.5014
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, BCL2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESR2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, XDH 3.46257
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS, TOP1 3.40003
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.38229
[BP] GO:0065007 biological regulation ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR6, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, RELA, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP1, XDH 3.37257
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.35713
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGES, PTGS2, RELA, SRC 3.35567
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.33662
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.33662
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES, PTGS2, TERT 3.32738
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CDK6, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PTGS2, RELA, SRC 3.29729
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC, TYR 3.25107
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, ESR1, F10, F3, FLT3, FUT7, GBA2, HMGCR, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLB, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TOP1, TYR, XDH 3.23661
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, MPO, PTGS2, RELA, SRC, TYR 3.23114
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.21393
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.21393
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 3.20978
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 3.13571
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 3.11378
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, GRM1, HMGCR, IGF1R, MAP2K1, MAP3K7, MIF, PTPN1, SRC 3.11178
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 3.10703
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, MIF, SRC, TNKS, TNKS2 3.10484
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, MAP3K7, MMP12, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC 3.09927
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 3.0982
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.0982
[BP] GO:0006693 None CES2, MIF, PTGES, PTGS2 3.0982
[BP] GO:0006692 None CES2, MIF, PTGES, PTGS2 3.0982
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, MPO, PTGS2, RELA, SRC 3.09722
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, SRC 3.09722
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.09722
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, MAP2K1, PTGS2, SRC 3.08172
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.08172
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MAP2K1, MAP3K7, MET, MIF, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, XDH 3.07725
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, GRM1, HMGCR, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 3.07432
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, HSD11B2, IGF1R, PPARA, PTGS2, RELA, SRC 3.0449
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MAP2K1, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 3.04035
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, HMGCR, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 3.03269
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CDK6, CYP1B1, FABP3, IDO1, MAP2K1, PTGES, PTGS2, TERT, XDH 3.03269
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CHRM1, CNR1, CYP19A1, GRIK5, GRM5, HCAR2, HMGCR, MAP2K1, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT 3.03158
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1, HSD17B3 2.99422
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 2.9822
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, GRM1, GRM5, MAP2K1, MAP3K7, MET, MIF, MMP9, PTPN1, RELA, SRC, TERT, TNKS, XDH 2.97341
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.96643
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAP2K1, MET, MIF, MMP12, MMP9, MPO, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 2.95292
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.94658
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, GRM1, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MIF, PTPN1, SRC, XDH 2.94658
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.9462
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC, TYR 2.93572
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PTGS2, SRC 2.9266
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 2.90223
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.90223
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 2.89658
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 2.89561
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HMGCR, HSD11B2, IDO1, MMP12, MPO, PTGES, PTGS2, RELA, SRC, TYR 2.86587
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, CNR2, ESR1, ESR2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, XDH 2.8548
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 2.85101
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.85101
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 2.85101
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.85101
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, CNR2, ESR1, ESR2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, RELA, SRC, TERT, XDH 2.84631
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, HCAR2, PTGS2, TNKS, TNKS2 2.83976
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.83976
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.7933
[BP] GO:0019371 None PTGES, PTGS2, TBXAS1 2.7933
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.7767
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.73597
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 2.7324
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, PPARA, PTGS2, RELA 2.71777
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, POLB, PTGS2, PTPN1, SRC, TNKS, TOP1, XDH 2.70419
[BP] GO:0009115 None AOX1, XDH 2.70199
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.68806
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, BCL2, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.68618
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 2.68152
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.61278
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, RELA, SRC 2.58876
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.58685
[BP] GO:0001516 None MIF, PTGES, PTGS2 2.58685
[BP] GO:0046457 None MIF, PTGES, PTGS2 2.58685
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, MIF, PTGES, PTGS2 2.5828
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, MAP2K1, MAP3K7, MIF, PTPN1, SRC 2.56065
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.5408
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 2.5397
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TNKS 2.52323
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.51816
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.50936
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.50065
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2, TERT 2.48944
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.48463
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.48152
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HMGCR, IDO1, KDR, MAP2K1, PIM1, PTGS2, RELA, SRC, TERT 2.46954
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CACNA1C, CHRM1, CNR1, CSNK2A1, HCAR2, HMGCR, MIF, MMP12, PTGS2, PTPN1, SRC, TERT 2.46925
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.45313
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, CHRM1, CNR1, HCAR2, HMGCR, MIF, MMP12, PTGS2, PTPN1, SRC 2.44969
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CACNA1C, CHRM1, CNR1, GRM5, MIF, MMP9, PTGS2 2.4492
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS, TOP1 2.43564
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, HMGCR, PTGS2, RELA, TYR 2.43564
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, GRM1, MAP2K1, MAP3K7, MIF, PTPN1, SRC 2.42642
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.42455
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.42375
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 2.42114
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, HCAR2, IDO1, MAP3K7, MIF, MMP12, MMP2, PTPN1, RELA, SRC 2.4159
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, MIF 2.40967
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF 2.40967
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, RELA, TYR 2.40967
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.40967
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.40899
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC 2.35575
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.35575
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.35575
[BP] GO:0070920 None ESR1, MAP2K1, TERT 2.35575
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, POLB, PTGS2, PTPN1, SRC, TNKS, TOP1, XDH 2.31513
[BP] GO:0099566 None GRM1, GRM5 2.30866
[BP] GO:0046110 None AOX1, XDH 2.30866
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.30866
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, ESR1, GRM5 2.30866
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, F3, FABP4, IDO1, KDR, MET, MIF, PTGS2 2.29582
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.29061
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, MAP2K1, MAP3K7, MIF, PTPN1, SRC 2.28855
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC 2.2738
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, PTGS2, RELA, SRC 2.26875
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, IDO1, MAP2K1, MAP3K7, MIF, MMP2, MMP9, MPO, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TERT 2.25368
[BP] GO:2000107 negative regulation of leukocyte apoptotic process AURKB, AXL, IDO1, MIF 2.24493
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, HMGCR, IGF1R, MAP2K1, MAP3K7, MET, MIF, PTGS2, PTPN1, TERT, XDH 2.2316
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.22479
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.19566
[BP] GO:0008217 None ADORA1, AR, CNR1, HSD11B2, PPARA, PTGS2 2.19331
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.18566
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.16569
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.16194
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F10, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, SRC, TNKS, TOP1 2.15636
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, MIF, MMP9, PTGS2, PTPN1, RELA, SRC, TERT 2.13054
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, PTGS2, SRC 2.1092
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.09489
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, MAP3K7, PIM1, RELA 2.07721
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.07228
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 2.07228
[BP] GO:0019233 None CNR1, CNR2, GRM1, PTGS2 2.06984
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.06984
[BP] GO:0070213 None TNKS, TNKS2 2.06082
[BP] GO:0006145 None AOX1, XDH 2.06082
[BP] GO:0038171 None CNR1, CNR2 2.06082
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.06082
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.0589
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.0589
[BP] GO:0032094 None CYP1A1, HSD11B2, MPO 2.0589
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, HSD11B2, IDO1, KDR, MAP2K1, MET, MMP1, MMP12, MPO, POLA1, RELA, SRC, TOP1 2.0589
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, GRM1, GRM5, MAP2K1, MAP3K7, MIF, PTPN1, SRC, TNKS 2.05764
[BP] GO:0050730 None ADORA1, APP, FLT3, GRM5, MIF, PTPN1, SRC 2.04517
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MPO 2.04346
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD17B3, TYR 2.03803
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, RELA, SRC, TERT 2.02586
[BP] GO:0090344 None CDK6, MIF, TERT 2.00867
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.00867
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.00867
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.00867
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR6, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, PTGS2, PTPN1, SLC1A1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR 5.73065
[CC] GO:0098590 plasma membrane region ABCG2, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC 4.87848
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, FLT3, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS2, PTPN1, TBXAS1 4.86653
[CC] GO:0097060 None CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 4.46218
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, ESR1, F10, F3, FLT3, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TERT 4.37076
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 4.28167
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS2, TBXAS1 4.06132
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR6, IGF1R, KDR, MET, SLC1A1 4.02815
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.01666
[CC] GO:0044425 membrane part ABCG2, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR6, IGF1R, KDR, MAOA, MET, PTGES, PTGS2, PTPN1, SLC1A1, SRC, TBXAS1, TYR 3.95385
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CDK6, CES2, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, KDR, MAOA, MAP2K1, MAP3K7, MIF, MMP2, MMP9, MPO, PIM1, POLA1, PTGES, PTGS2, PTPN1, RELA, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 3.65054
[CC] GO:0044459 plasma membrane part ABCG2, ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR6, IGF1R, KDR, MET, PTGS2, SLC1A1, SRC 3.38229
[CC] GO:0014069 None ADORA1, CACNA1C, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 3.15947
[CC] GO:0099572 None ADORA1, CACNA1C, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 3.15947
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.15802
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC 3.0801
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CES2, CYP19A1, FLT3, GBA2, GRIK5, HMGCR, HSD17B3, KDR, MAP2K1, PTGS2, PTPN1, XDH 2.86156
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR6, IGF1R, KDR, MET, SLC1A1 2.85101
[CC] GO:0097458 None ADORA1, APP, CA2, CACNA1C, CHRM1, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IDO1, PTGS2, SRC, TOP1 2.42375
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR6, PTGS2, SRC 2.30866
[CC] GO:0043226 organelle ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA9, CACNA1C, CDK6, CES2, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HMGCR, HSD17B3, HTR6, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MIF, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RELA, SHBG, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 2.30494
[CC] GO:0045211 None CHRM1, CHRM2, CHRM4, GRIA2, GRIA4, GRIK5, GRM3 2.24011
[CC] GO:0031233 None CA4, F10, F3 2.09919
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR6, PTGS2, SRC 2.0589
[CC] GO:0044464 cell part ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CDK6, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR6, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, RELA, SLC1A1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 2.04809
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TYR, XDH 12.2744
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PTGES, PTGS2, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 11.2534
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, MPO, PTGS2, TBXAS1, TYR, XDH 10.5304
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B2, HSD17B1, IDO1, MPO, POLA1, PTGES, PTGS2, SRC, TBXAS1, XDH 9.29836
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.20375
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, RELA, SLC1A1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 9.02027
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, MPO, PTGS2, SRC, TBXAS1 8.69866
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, MPO, PTGS2, SRC, TBXAS1 8.39408
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 7.53092
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.4481
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, MET, PPARA 7.32414
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, SHBG 6.63972
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TBXAS1, XDH 6.63972
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, PPARA 6.63132
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, MET, PPARA 6.63132
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TBXAS1, TYR 6.33391
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, MET, PPARA 6.32658
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.3025
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.25009
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 5.95381
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR6 5.95381
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS2, TBXAS1, TYR 5.80642
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, SLC1A1, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 5.80367
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MAP3K7, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, SLC1A1, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 5.59553
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.54767
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, TNKS 4.7325
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 4.7325
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.56326
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 4.53106
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 4.53106
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, MET 4.51203
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR6, IGF1R, KDR, MET 4.51203
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.42842
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.29614
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 4.12138
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 3.98943
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC, TOP1 3.95385
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.81195
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.79114
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, SHBG 3.79025
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 3.51276
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 3.36353
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.03158
[MF] GO:0042802 identical protein binding ABCG2, ACHE, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, MAP3K7, MET, MIF, MMP9, PTGS2, RELA, TERT, TYR, XDH 2.9462
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 2.89785
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 2.75852
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.70199
[MF] GO:0003845 None HSD11B1, HSD11B2 2.70199
[MF] GO:0008389 None CYP2A13, CYP2A6 2.70199
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.5828
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR6 2.5408
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, POLA1, POLB, SRC, TERT, TOP1 2.54072
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.46609
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, MET, MIF, POLA1, POLB, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS2 2.39661
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, SHBG 2.34475
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.30866
[MF] GO:0004949 None CNR1, CNR2 2.30866
[MF] GO:0099583 None GRM1, GRM5 2.30866
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.22479
[MF] GO:0003674 molecular_function ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CDK6, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR6, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, RELA, SHBG, SLC1A1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 2.21339
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.16194
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.16194
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.09919
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 2.07638
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.06082
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.06082
[MF] GO:0004971 None GRIA2, GRIA4 2.06082
[MF] GO:0005497 None AR, SHBG 2.06082
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.06082


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 10.4759
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM1, CHRM4, GRIK5, GRM1, GRM3, HTR6, GRM5, CNR2, CNR1, ADORA3, GRM8, ADORA1, GRIA4 9.5535
Metabolic pathways_Homo sapiens_hsa01100 MAOA, HSD17B3, AKR1B1, HMGCR, PTGS2, CYP3A4, GBA2, CYP19A1, HSD11B1, FUT7, ALDH2, ALOX5, HSD17B1, HSD17B2, AOX1, XDH, TYR, POLA1, CYP2A6, AKR1B10, TBXAS1, CYP1A2, CYP1A1, ALPL, PTGES, IDO1 8.4346
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.4346
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.0716
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 7.6061
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, HTR6, MAP2K1, CHRM1, ADORA1, CACNA1C, PPARA, RELA, GRIA4 7.0785
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 7.0208
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 6.9223
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, CDK6, FLT3, MMP1, MMP2, BCL2, PTGS2, MMP9, MET, RELA, IGF1R 5.1111
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.9423
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, ESR1, GRM1, ESR2 5.1047
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, MAP2K1, CHRM1, CHRM4, BCL2, CACNA1C 4.8655
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CNR1, CACNA1C, PTGS2, GRM1, GRIA4 5.0801
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, MAP2K1, MAOA, ALOX5, CACNA1C, PTGS2 4.8655
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.2108
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 4.794
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, CDK6, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.9007
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, CDK6, CHRM1, KDR, BCL2, MET, RELA, IGF1R 3.5426
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 4.794
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, MAP2K1, CACNA1C, GRM1 3.8456
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 3.8579
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, ESR1, ESR2, RELA 3.7165
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1, CYP3A4 3.7703
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, CDK6, SRC, BCL2, MMP9, RELA 3.309
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, RELA, IGF1R 3.3184
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3, RELA 3.1183
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2, MAP3K7, RELA 3.2601
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PTGS2, MMP9, MAP3K7, RELA 2.9702
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, GRM5, CHRM1, CACNA1C, GRM1 2.9404
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, RELA, IGF1R 2.9404
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, BCL2, ADORA1, RELA 2.8649
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, BCL2, MET, IGF1R 2.7345
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.0234
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, CNR1, KDR, MET, IGF1R 2.6442
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR, PTGS2 2.9465
Long-term depression_Homo sapiens_hsa04730 GRIA2, MAP2K1, GRM1, IGF1R 2.9622
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, MAP2K1, GRM8, GRM1 2.5722
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF, TYR 3.7277
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2 3.3184
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA, RELA 3.254
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, CACNA1C, GRIA4 2.8456
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2, PTGES 2.9404
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6, MET, IGF1R 2.7796
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.436
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, BCL2, RELA, IGF1R 2.2449
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, MAP2K1, CHRM1, SRC, CHRM4 1.9083
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2, RELA 2.5106
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4, ABCG2 2.7796
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA 2.0456
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8072
Gap junction_Homo sapiens_hsa04540 GRM5, MAP2K1, SRC, GRM1 2.482
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, CACNA1C, GRIA4 1.9296
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KDR, MET, RELA, IGF1R 1.8419
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, MAP3K7, RELA 1.8844
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 1.6714
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, PTGS2 1.7022
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C 1.6377
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, MAP3K7, RELA 1.4104
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC, RELA 1.3946
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.0459
Glioma_Homo sapiens_hsa05214 MAP2K1, CDK6, IGF1R 1.9083
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.5258
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.4458
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, RELA 1.8156
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA, RELA 1.4191
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, RELA 1.8969
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.4622
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET 1.8857
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.5566
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, BCL2, RELA 1.3356
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.3127
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC, ESR1 1.3495
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.147
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.217
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, MAP3K7, IGF1R 1.3087
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 1.8156
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.2116
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 1.9974
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.251
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.2581
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, GRM1, IGF1R 1.2545
Phagosome_Homo sapiens_hsa04145 MPO 0.2756
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 1.8817
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, ESRRB, IGF1R 1.2051
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1149
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.313
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 0.9763
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.0088
Axon guidance_Homo sapiens_hsa04360 MET 0.3298
HTLV-I infection_Homo sapiens_hsa05166 POLB, TERT, RELA 0.7131
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7014
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 0.9731
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7312
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7479
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7289
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.5832
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.687
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.687
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.7395
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 0.7014
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C 0.6617
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.6786
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.3902
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.5991
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA 0.5832
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.5779
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.6523
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.3893
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3977
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.3977
Amoebiasis_Homo sapiens_hsa05146 RELA 0.3977
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4068
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4009
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4056
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.4117
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 0.8614
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4168
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4182
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4182
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4182
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 0.9
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4217
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4182
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4182
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4233
Peroxisome_Homo sapiens_hsa04146 XDH 0.4292
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 0.9508
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4327
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 0.9747
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4292
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4436
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.9458
Pertussis_Homo sapiens_hsa05133 RELA 0.4552
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0088
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4574
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.0536
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4574
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.4803
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0047
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4777
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.0822
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4947
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.1156
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.4947
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.0822
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.4831
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RELA 0.4916
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.1312
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, BCL2 1.1475
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.1233
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, CDK6 1.2116
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.2054
Legionellosis_Homo sapiens_hsa05134 RELA 0.5461
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.5648
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.5648
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.2666
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2, MAOA 1.2777
Malaria_Homo sapiens_hsa05144 MET 0.5792
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5839
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.5832
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.3059
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.5618
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5839
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.6008
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6362
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6008
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.419
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.6668
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6323
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.6668
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.6323
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.71
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6192
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.7289
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6964
DNA replication_Homo sapiens_hsa03030 POLA1 0.6617
Base excision repair_Homo sapiens_hsa03410 POLB 0.6809
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5709
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.6377
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.6964
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.71
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7303
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7289
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.7289
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.808
Histidine metabolism_Homo sapiens_hsa00340 ALDH2, MAOA 1.7781
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.7841
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 1.9914
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.8655
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8614
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9508
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.224


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)