TCM Prescription: Zhi Ke Bao Tablet



Prescription Description
Prescription IDTCMF316
Pinyin NameZhi Ke Bao Pian 
Chinese Name止咳宝片
English NameZhi Ke Bao Tablet
Function Description外感风寒所致的咳嗽, 痰多清稀, 咳甚而喘; 慢性支气管炎, 上呼吸道感染见上述证候者
IndicationsAsthma, Upper respiratory infection(uri), Bronchitis
Disease ICD-11 Category CA23 [Asthma, 哮喘 ];
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
CA20 [Bronchitis, 支气管炎 ];
Human Tissues Associated with IndicationLung, Bronchus
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2728 Aster tataricus 紫菀 TCMH2728 ITSAI2445-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH46 Stemona tuberosa 百部 TCMH46 GBVC4204-11, GBVC4202-11
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH1179 Citri exocarpium rubrum 橘红 TCMH1179
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH2514 Papaver somniferum 罂粟 TCMH2514 ITSAD207-14
TCMH1386 NA 氯化铵 TCMH1386
TCMH190 NA 薄荷素油 TCMH190
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PDE3A, PPARA, TBXAS1, TRPV1 14.9807
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, FUT7, GBA2, PDE10A, PDE3A, PDE3B, PIM1, PPARA, TBXAS1, TYR, XDH 13.0522
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.6578
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, OPRK1, OPRM1, PDE3A, PDE3B, POLB, PPARA, RORC, SRC, TRPV1, TYR 12.6211
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLB, PPARA, RORC, SRC, TRPV1, TYR 11.8819
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.8819
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SENP6, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 11.596
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2A, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLB, PPARA, RORC, SRC, TERT, TRPV1, TYR 11.2035
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F2, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, KDR, KIT, MET, OPRD1, OPRK1, OPRM1, PDE3A, POLA1, POLB, PPARA, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 10.9177
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 10.5375
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.4999
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.486
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 10.2471
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 10.2471
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, OPRK1, OPRM1, PDE3A, RORC, SRC, TRPV1, TYR 9.78774
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, FABP3, FABP4, FUT7, GBA2, KIT, MET, PDE3A, PPARA, TBXAS1 9.00973
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, KIT, MMP2, NR3C1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TRPV1 8.86548
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, KIT, MET, MMP1, MMP2, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SENP6, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 8.7458
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 8.28352
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, OPRK1, OPRM1, RORC, SRC, TYR 8.11056
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, RORC, SRC, TERT, TRPV1 8.08409
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA3, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HSD11B2, HTR2A, KDR, NR3C1, OPRK1, OPRM1, PDE3A, POLB, SRC, TRPV1 7.97519
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F2, F3, FABP3, FLT3, HTR1A, HTR2A, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, OPRM1, PIM1, SRC, TERT, XDH 7.85676
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, RORC, SRC, TRPV1 7.80007
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F2, F3, FLT3, HTR2A, KDR, KIT, MET, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.80007
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F2, F3, FLT3, HTR2A, KDR, KIT, MET, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.76506
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 7.73556
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F2, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, RORC, SRC, TNKS2, TRPV1, TYR 7.40725
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, TBXAS1 7.3599
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 7.34219
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR2A, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TERT, TRPV1, TYR 7.19232
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, NR3C1, OPRK1, PDE3B, PPARA, SRC, TRPV1 7.15327
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HTR1A, HTR2A, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 7.05848
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, KIT, MMP9, SRC, TERT 6.81217
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, ESR1, F2, F3, FLT3, HTR1A, HTR2A, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, TERT 6.67865
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, F2, HTR2A, KDR, OPRK1, SRC, TNKS, TNKS2, TRPV1 6.66084
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, GBA2, HTR1A, TYR 6.53661
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SENP6, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 6.51764
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, HSD11B2, HTR2A, KIT, MMP2, OPRD1, OPRK1, OPRM1, POLB, PPARA, SRC, TERT, TRPV1, TYR 6.50853
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, TRPV1 6.50429
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.45639
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, OPRK1 6.28524
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, KDR, KIT, MET, MMP2, MMP9, PDE3A, PDE3B, PIM1, POLB, PPARA, RORC, SIGMAR1, SRC, TERT, TNKS2, TYR 6.20427
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SENP6, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 6.16596
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLA1, POLB, PTPN1, RORC, SRC, TERT, TRPV1 6.1494
[BP] GO:0007193 None ADORA1, CHRM2, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 6.12893
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F2, F3, FLT3, HTR2A, KDR, KIT, MET, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.00343
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, F2, HTR2A, KDR, SRC, TRPV1 5.98439
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CYP1A1, CYP1B1, DRD1, DRD2, KDR, OPRD1, OPRK1, POLB, SRC 5.83446
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PPARA, TBXAS1 5.78916
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.72382
[BP] GO:0007200 None CHRM2, DRD1, DRD2, ESR1, HTR2A, OPRD1, OPRK1, OPRM1 5.70342
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, HTR7, KIT, OPRK1, OPRM1, PPARA, RORC, SRC 5.65147
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, NR3C1, OPRM1, PDE3A, RORC, SRC, TRPV1 5.61512
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F2, F3, HTR1A, HTR2A, IGF1R, KDR, KIT, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, TERT, TRPV1 5.60387
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2A, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.56612
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.47024
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.42791
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.42791
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, F2, F3, FLT3, HTR2A, KDR, KIT, MET, OPRK1, OPRM1, PTPN1, SRC, XDH 5.36231
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, OPRK1, SRC, TERT 5.26254
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HTR2A, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.22384
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP3, FLT3, HTR2A, KDR, KIT, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 5.22384
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP3, FLT3, HTR2A, KDR, KIT, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 5.22384
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HTR2A, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.20101
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLB, PPARA, PTPN1, RORC, SIGMAR1, SRC, TNKS, TNKS2, TRPV1 5.17517
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.17027
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, TRPV1 5.16922
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F2, F3, FLT3, HTR2A, IGF1R, KDR, KIT, MET, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, XDH 5.1499
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F2, F3, FLT3, HTR1A, HTR2A, IGF1R, KDR, KIT, MET, MMP12, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.1189
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.09485
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, SRC, XDH 5.0927
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.0927
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.0927
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, F2, FABP3, FABP4, FLT3, HTR2A, MET, POLA1, POLB, SRC, TERT, TRPV1 5.04008
[BP] GO:0007188 None ADORA1, CHRM2, DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 5.02052
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, RORC 4.92073
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HTR2A, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.91681
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CDK6, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, NR3C1, OPRK1, PDE3A, PDE3B, RORC, SRC, TRPV1 4.90697
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TRPV1, TYR 4.85465
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F2, F3, FLT3, HTR1A, HTR2A, IGF1R, KDR, KIT, MET, MMP12, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.85465
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PDE3A, PIM1, PPARA, PTPN1, SIGMAR1, SRC, TERT, TRPV1, XDH 4.84585
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PDE3A, PIM1, PTPN1, SIGMAR1, SRC, TERT, TRPV1, XDH 4.83499
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD1, DRD2, HTR2A, MET, TRPV1 4.83098
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.77493
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESRRA, F2, F3, FABP4, FLT3, HTR2A, KDR, KIT, MET, MMP12, MMP2, MMP9, OPRK1, OPRM1, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.77484
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, OPRD1, POLB, PPARA, SRC, TERT 4.70809
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2A, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.69795
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, ESRRB, F2, FLT3, HTR2A, KDR, KIT, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 4.67356
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 4.65532
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.62972
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, F2, OPRM1, PPARA 4.57975
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, KIT, MET, PDE10A, PDE3A, PDE3B, PIM1, POLB, PTPN1, SRC, TNKS, XDH 4.57975
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.55079
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HTR2A, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.52107
[BP] GO:0007187 None ADORA1, CHRM2, DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 4.51025
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PIM1, POLB, PPARA, RORC, SIGMAR1, SRC, TYR 4.50741
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TRPV1, TYR 4.45159
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, BCL2, CA2, CDK6, CHRM2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F2, F3, HTR2A, KDR, KIT, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, SRC, TERT, TNKS2, TRPV1, XDH 4.36821
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP4, FLT3, HTR2A, IGF1R, KDR, KIT, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, XDH 4.35534
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, KIT, MMP9, TERT 4.35534
[BP] GO:0030534 None APP, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 4.32912
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A, TRPV1 4.31723
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, F2, FLT3, HTR2A, KDR, KIT, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 4.30358
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PDE3A, PIM1, PPARA, PTPN1, SRC, TERT 4.27323
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, OPRD1, PPARA, SRC, TERT 4.26114
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, SRC, TNKS, TNKS2, TRPV1 4.25099
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, KIT, MET, PDE10A, PDE3A, PDE3B, PIM1, POLB, PTPN1, SRC, TNKS, XDH 4.22938
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.22938
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, TBXAS1, TYR 4.21696
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, OPRK1, SRC, TERT 4.21696
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SENP6, SIGMAR1, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 4.20687
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, POLB, PPARA, SRC, TYR 4.20091
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, OPRD1, PPARA, SRC, TERT 4.16983
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PDE3A, PIM1, PTPN1, SRC, TERT 4.16434
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PDE3A 4.01629
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, HTR2A, KDR, KIT, OPRK1, OPRM1, PTPN1, SRC, XDH 4.01165
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, HTR2A, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.00813
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, KDR, NR3C1, OPRM1, SRC, TRPV1 3.97017
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, DRD1, DRD2, F2, HTR1A, HTR2A, MMP9, OPRD1, OPRK1, OPRM1 3.9434
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, IGF1R, KDR, KIT, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, XDH 3.91495
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.88058
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, F2, FABP3, FLT3, HTR2A, KIT, PDE3B, PPARA, RORC, SRC 3.88058
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2 3.88058
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, IGF1R, KDR, KIT, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, XDH 3.86859
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, F2, FABP4, FLT3, HTR2A, IGF1R, KDR, KIT, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 3.84171
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 3.83539
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MMP9, PDE3A, PIM1, PTPN1, SIGMAR1, SRC, TERT, TRPV1, XDH 3.8329
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.74988
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM2, DRD1, DRD2, ESR1, F2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, SIGMAR1, SRC 3.71031
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F2, F3, HTR2A, KDR, KIT, MET, MMP12, MMP9, OPRM1, PDE3A, PIM1, SRC, TERT, TRPV1 3.71031
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, TBXAS1, TYR 3.70227
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, KIT, SRC 3.69191
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A, TYR 3.68061
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, HTR2A, KIT, PPARA, SRC 3.67583
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.64332
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PDE3A 3.63744
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.63744
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.63744
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 3.62416
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.62416
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, TBXAS1, TYR 3.62416
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, F2, HSD11B2, HTR1A, KIT, MMP2, MMP9, OPRD1, OPRK1, OPRM1, POLA1, POLB, PPARA, PTPN1, SRC, TERT, TRPV1 3.60486
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR7, TRPV1 3.47838
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, F2, HTR1A, HTR2A, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, TERT, TRPV1 3.47623
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DRD1, ESR1, FLT3, IGF1R, KIT, MMP2, NR3C1, OPRM1, PDE3A, PDE3B, SRC, TRPV1 3.43733
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.41672
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, OPRK1, OPRM1, PDE3A, SRC 3.41445
[BP] GO:0072523 None AOX1, PDE10A, PDE3A, PDE3B, XDH 3.40271
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CDK6, CYP19A1, DRD1, DRD2, ESR1, ESR2, F2, IGF1R, MET, MMP12, MMP9, PDE3B, PPARA, PTPN1, SRC, TERT, XDH 3.39566
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 3.38513
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, F2, F3, FLT3, FUT7, GBA2, HTR1A, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, POLB, PPARA, PTPN1, SENP6, SRC, TNKS, TNKS2, TYR, XDH 3.33227
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.3192
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC, TERT, TNKS 3.31323
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.29196
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.25544
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, OPRK1, PDE3B, PPARA, SRC, TRPV1 3.25544
[BP] GO:0007631 None APP, DRD1, DRD2, OPRD1, OPRK1, OPRM1 3.24038
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, HTR2A, IGF1R, KDR, KIT, OPRK1, OPRM1, PTPN1, SRC, XDH 3.21887
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, DRD2, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SRC, TERT, XDH 3.2005
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 3.18727
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, DRD2, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SRC, TERT, XDH 3.18727
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, ESR1, FABP4, IGF1R, MET, MMP9, OPRM1, PIM1, PPARA, PTPN1, SRC, TNKS 3.18727
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HTR2A, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TRPV1 3.17409
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, F2, FABP3, FABP4, HTR2A, MET, TRPV1 3.14785
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, F2, F3, FLT3, HTR2A, IGF1R, KDR, KIT, MET, MMP12, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.12763
[BP] GO:0007610 None APP, BCL2, DRD1, DRD2, HTR1A, HTR2A, KIT, OPRD1, OPRK1, OPRM1, PPARA, TRPV1 3.11333
[BP] GO:0003018 None ADORA1, DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 3.09424
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.09424
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PDE3A, PIM1, PTPN1, SRC, TERT 3.03982
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.02139
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.01497
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, F2, FLT3, HTR2A, KDR, KIT, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 3.00519
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, KIT, MET, PIM1, POLA1, SRC, TYR 2.9963
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CDK6, CYP19A1, DRD2, ESR1, F2, F3, FABP4, IGF1R, MET, MMP12, MMP2, OPRK1, PPARA, PTPN1, SRC, TERT, XDH 2.99317
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, F2, TNKS, TNKS2 2.99296
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, HTR2A, KIT 2.96895
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, HTR2A, KIT 2.96895
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.96255
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 2.94277
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F2, F3, FLT3, HTR2A, KDR, KIT, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.89475
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 2.87095
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC, TRPV1 2.84667
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, DRD2, ESR1, F2, F3, FABP4, KDR, MET, MMP12, OPRM1, PPARA 2.84547
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.84063
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F2, F3, HTR2A, KDR, KIT, OPRM1, PDE3A, PDE3B, PIM1, PPARA, RORC, SRC, TERT, TNKS2, TRPV1, XDH 2.8324
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, KIT, SRC 2.8311
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CYP1B1, DRD1, DRD2, HSD11B2, HTR1A, HTR2A, HTR7, KIT, OPRD1, OPRK1, OPRM1, PDE3A, SRC, TRPV1, TYR 2.79382
[BP] GO:0051930 None ADORA1, OPRD1, OPRK1, OPRM1 2.78546
[BP] GO:0051931 None ADORA1, OPRD1, OPRK1, OPRM1 2.78546
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, ESR1, ESR2, ESRRA, F2, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, OPRD1, OPRM1, PDE3B, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.76062
[BP] GO:0008306 None APP, DRD1, DRD2, KIT, OPRK1 2.75071
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, ESR1, F2, F3, FLT3, HTR2A, KDR, KIT, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.74616
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.74616
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.74616
[BP] GO:0031635 None OPRK1, OPRM1 2.74616
[BP] GO:0009115 None AOX1, XDH 2.74616
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.74616
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.74616
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.74616
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, KIT, SRC 2.74616
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2 2.74544
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A 2.72739
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, PDE10A, PDE3A, PDE3B, XDH 2.67893
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 2.66999
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, KIT, OPRK1, OPRM1, POLB, TYR 2.65991
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.65807
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, HTR2A, OPRM1, PPARA, TRPV1 2.65004
[BP] GO:0051952 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 2.64711
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 2.63514
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3, KIT 2.62434
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC, TRPV1 2.61906
[BP] GO:0097756 None ADORA1, HTR1A, HTR2A, HTR7 2.59628
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3, KIT 2.57537
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, F2, F3, FABP4, FLT3, HTR2A, IGF1R, KIT, MET, MMP9, OPRD1, OPRM1, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TRPV1, XDH 2.57537
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.57537
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.57537
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.57537
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, F2, MMP12, OPRK1, SRC, TERT, TRPV1 2.54124
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, HTR2A, KDR, OPRM1, SRC 2.53736
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F2, F3, FLT3, HTR2A, KIT, MET, MMP9, OPRD1, PTPN1, SRC, TERT, TNKS, XDH 2.50544
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, HTR2A, KDR, OPRM1, PTPN1, SRC 2.49672
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.49511
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.49511
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.49511
[BP] GO:0032868 None FABP3, HSD11B2, OPRK1, PDE3B, PPARA, SRC 2.45526
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, XDH 2.45526
[BP] GO:0070848 response to growth factor APP, KDR, NR3C1, OPRD1, OPRM1, PDE3A, SRC, TRPV1 2.45322
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.44852
[BP] GO:0003013 None ADORA1, DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 2.44852
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, PDE10A, PDE3A, PDE3B, XDH 2.43957
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, F2, FABP4, FLT3, HTR2A, IGF1R, KDR, KIT, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.43076
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.42252
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.42252
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F2, FLT3, IGF1R, KDR, KIT, MET, SENP6, SRC, TNKS 2.41306
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, IGF1R, MET, MMP12, NR3C1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TRPV1 2.40591
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F3, KIT, MET, SRC, XDH 2.38227
[BP] GO:2001023 None DRD1, DRD2, HTR2A, MET, OPRK1 2.37198
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, F2, FABP3, HTR2A, TRPV1 2.35411
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.35411
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B 2.35411
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.35411
[BP] GO:0046110 None AOX1, XDH 2.35411
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.35411
[BP] GO:0007268 None CHRM2, DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.34693
[BP] GO:0098916 None CHRM2, DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.34693
[BP] GO:0051094 positive regulation of developmental process ALOX12, APP, AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F3, HTR2A, KDR, KIT, OPRM1, PDE3A, PIM1, SRC, TERT 2.3439
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, F2, HSD11B2, HTR2A, KIT, MMP12, OPRK1, OPRM1, SRC, TRPV1, TYR 2.31447
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, GBA2, PDE10A, PDE3A, PDE3B, SRC, XDH 2.30848
[BP] GO:0008542 None APP, DRD1, DRD2, KIT 2.30474
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, NR3C1, SRC 2.30405
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.29248
[BP] GO:0099536 None CHRM2, DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.2859
[BP] GO:0099537 None CHRM2, DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.2859
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 2.28119
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3B, PIM1, POLA1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.25971
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.24638
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, NR3C1, SRC 2.24444
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.23121
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.23121
[BP] GO:0043266 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 2.20906
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DRD2, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.20731
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, KIT, SRC 2.18725
[BP] GO:0050730 None ADORA1, APP, FLT3, HTR2A, KIT, PTPN1, SRC 2.18084
[BP] GO:0042391 None ADORA1, APP, BCL2, DRD1, KDR, OPRD1, OPRM1, SRC, TRPV1 2.18084
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, DRD2, F2, F3, MET, OPRK1, XDH 2.18084
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, HTR2A, IGF1R, MET, MMP12, NR3C1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2 2.1714
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PDE3A, SRC 2.1714
[BP] GO:0007632 None APP, DRD1, DRD2, KIT 2.16741
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.16741
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.16667
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.16177
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F2, F3, FABP4, FLT3, HTR2A, IGF1R, KIT, MMP9, OPRM1, PTPN1, SRC, TERT, TNKS, XDH 2.16053
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1 2.1483
[BP] GO:0032094 None CYP1A1, HSD11B2, OPRM1 2.12072
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, PDE3A, SENP6, TERT, TNKS 2.11462
[BP] GO:0007198 None HTR1A, HTR7 2.11462
[BP] GO:0070213 None TNKS, TNKS2 2.11462
[BP] GO:0006145 None AOX1, XDH 2.11462
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.11462
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, POLB, TYR 2.10845
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DRD2, ESR1, ESR2, F2, IGF1R, KDR, KIT, MET, MMP1, MMP9, OPRD1, PDE3A, PTPN1, SENP6, SRC, TNKS, TNKS2 2.10845
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SENP6, SIGMAR1, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 2.10543
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.09915
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.09118
[BP] GO:0042698 ovulation cycle AXL, OPRK1, OPRM1 2.08368
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.08368
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.08368
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, IGF1R, MET, MMP9, PDE3B, PTPN1, SRC, XDH 2.07233
[BP] GO:0071363 cellular response to growth factor stimulus APP, KDR, NR3C1, OPRD1, PDE3A, SRC, TRPV1 2.06676
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, F2, MMP12, PPARA 2.06676
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DRD1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, KIT, MET, MMP2, MMP9, PDE3A, RORC, SRC, TERT 2.06676
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.06676
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.06676
[BP] GO:0044057 None ADORA1, ADORA3, CHRM2, DRD2, HTR2A, KIT, OPRD1, OPRK1, OPRM1, TRPV1 2.06676
[BP] GO:1901342 regulation of vasculature development ALOX12, CYP1B1, F3, KDR, KIT, PDE3B, TERT, XDH 2.04995
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, HTR2A, KIT, PTPN1, SRC 2.04608
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, ESR1, ESR2, ESRRA, F2, FABP4, IGF1R, MET, MMP12, MMP9, NR3C1, OPRM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.04023
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.0382
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.03584
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.03364
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.03364
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, F3, KDR, KIT, TERT 2.02566
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.00856
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, F2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, KDR, KIT, MMP2, MMP9, NR3C1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, PTPN1, SENP6, SIGMAR1, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 4.71779
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, F2, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1, SIGMAR1, TBXAS1 4.24555
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, F2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, MMP2, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PIM1, PTPN1, SIGMAR1, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR 3.75196
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM2, DRD1, DRD2, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TRPV1 3.47226
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, SIGMAR1, TBXAS1 3.27762
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, OPRD1, OPRM1, SRC, TRPV1 2.8324
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, F2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTPN1, SIGMAR1, SRC, TBXAS1, TRPV1, TYR 2.78546
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM2, DRD1, DRD2, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TRPV1 2.74616
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CES2, CYP19A1, CYP2D6, FLT3, GBA2, KDR, OPRM1, PDE3B, PTPN1, SIGMAR1, XDH 2.63926
[CC] GO:0032589 None ADORA1, OPRD1, OPRM1, TRPV1 2.52302
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, DRD1, DRD2, ESR1, F2, F3, FLT3, GBA2, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, MMP2, OPRD1, OPRK1, OPRM1, PIM1, PTPN1, SRC, TERT, TRPV1 2.51441
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM2, DRD1, DRD2, F2, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TRPV1 2.28479
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM2, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TRPV1 2.17495
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM2, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TRPV1 2.17495
[CC] GO:0043679 None CHRM2, DRD2, OPRD1, OPRK1 2.11462
[CC] GO:0098793 None ADORA1, APP, CHRM2, DRD2, OPRD1, OPRK1 2.11462
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HTR2A, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRM1, PDE3B, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SIGMAR1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.11462
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM2, DRD1, DRD2, HTR2A, MET, OPRD1, OPRM1, SIGMAR1, SRC, TRPV1 2.02303
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, TBXAS1, TNKS, TYR, XDH 21.5969
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.758
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 15.5148
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, HTR1A, HTR2A, HTR7, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 14.6058
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, F2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PTPN1, SENP6, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 13.2834
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 11.7381
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6935
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 10.8921
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, XDH 10.5926
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 9.68759
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 8.86548
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, TNKS 8.86548
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 8.22905
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, RORC, SIGMAR1, TRPV1 8.11056
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 7.90608
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 7.54849
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, RORC, SIGMAR1, TRPV1 7.40555
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, RORC, SIGMAR1, TRPV1 7.05165
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, RORC 7.00569
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, SRC, TBXAS1 6.77324
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, SRC, TBXAS1 6.50429
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 6.29181
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, RORC, SIGMAR1, TRPV1 6.19569
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 6.07121
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B2, HSD17B1, POLA1, SRC, TBXAS1, XDH 5.74645
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 5.55836
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.55836
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DRD1, DRD2, FLT3, HTR2A, IGF1R, KDR, KIT, MET, PDE10A, PIM1, PPARA, SIGMAR1, SRC, TRPV1 5.55487
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, RORC, TRPV1 5.48487
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.44938
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.17027
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.72529
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.72529
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.20091
[MF] GO:0030594 None CHRM2, DRD1, DRD2, HTR1A, HTR2A, HTR7, OPRM1 3.97017
[MF] GO:0099528 None CHRM2, HTR1A, HTR2A, HTR7, OPRM1 3.91989
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM2, DRD1, DRD2, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TRPV1 3.88058
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, DRD1, DRD2, F3, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TRPV1 3.88058
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2A, HTR7 3.83108
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.75242
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.65281
[MF] GO:0008227 None CHRM2, DRD2, HTR1A, HTR2A, HTR7 3.15449
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.13765
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.09424
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.02338
[MF] GO:0043176 None HTR1A, HTR2A, HTR7 2.84063
[MF] GO:0051378 None HTR1A, HTR2A, HTR7 2.84063
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.74616
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.74616
[MF] GO:0003845 None HSD11B1, HSD11B2 2.74616
[MF] GO:0004119 None PDE3A, PDE3B 2.74616
[MF] GO:0008389 None CYP2A13, CYP2A6 2.74616
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 2.74114
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B 2.57537
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.49511
[MF] GO:0016788 None ACHE, ADORA1, ALPL, CA1, CA2, CA3, CDC25B, CES2, PDE10A, PDE3A, PDE3B, POLA1, PTPN1 2.46633
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.42419
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, MMP12, NR3C1, PDE10A, PDE3A, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TBXAS1, TERT, TRPV1, XDH 2.38362
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.35411
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.35411
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.35411
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR7 2.18725
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.17495
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.11462
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.11462
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.11462
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SENP6, SIGMAR1, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 2.10543
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.08368
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.06676


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.8483
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.493
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, CHRM2, HTR1A, OPRK1, OPRM1, TRPV1, HTR2A, NR3C1, F2, HTR7, ADORA3, ADORA1, DRD1, DRD2 8.9333
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.8579
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.14
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.3793
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.0979
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR7, CYP2D6, ALOX5, ALOX15, HTR1A, ALOX12, HTR2A 6.1453
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, PDE3B, ADORA1, PDE3A, HTR1A, DRD1, DRD2, PPARA 4.3465
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, ADORA1, PDE3A, OPRM1, DRD1 4.3465
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, OPRM1, MMP9, ESR1, ESR2 4.1712
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, ALOX12 4.0151
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.556
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 3.9458
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP3A4 3.8483
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R 3.2901
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.7277
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.5814
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, DRD2, MET, IGF1R 2.6517
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.563
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 2.6517
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, KIT, KDR, BCL2, MET, IGF1R 2.3302
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2 3.409
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, ADORA3, PDE3B, ADORA1, PDE3A 2.3118
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.2686
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7607
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1, HTR2A 2.3026
Gap junction_Homo sapiens_hsa04540 SRC, HTR2A, DRD1, DRD2 2.4304
Purine metabolism_Homo sapiens_hsa00230 POLA1, PDE10A, PDE3B, PDE3A, XDH 2.2545
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.0443
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KIT, KDR, MET, IGF1R 1.8623
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, ADORA3, BCL2, ADORA1 2.0443
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.8225
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.6757
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PDE3B, ADORA1 2.0443
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.0443
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR7, HTR2A, DRD1 1.5553
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 1.8748
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.8265
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8225
Renin secretion_Homo sapiens_hsa04924 PDE3B, ADORA1, PDE3A 1.9194
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5553
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PDE3B, CDC25B, IGF1R 1.5293
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.4099
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.7324
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.0882
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.0649
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 0.862
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, F2 0.828
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.8745
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.8658
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.8196
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.8821
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.8745
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B, PPARA 0.8182
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.0925
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.7794
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9435
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.0649
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.8156
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7196
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7383
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.862
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7383
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.7383
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 0.9408
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.6751
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7133
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1639
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.0366
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.7009
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PDE3B 0.6751
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.0099
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6731
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6751
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1113
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5479
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.6731
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.4917
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.5479
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.24
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2626
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.24
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2626
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.2762
Apoptosis_Homo sapiens_hsa04210 BCL2 0.2972
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.2897
HTLV-I infection_Homo sapiens_hsa05166 POLB, TERT 0.4052
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.2868
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.2961
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.2949
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3102
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3102
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.3228
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3228
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3267
Axon guidance_Homo sapiens_hsa04360 MET 0.3184
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3522
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.3645
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.3922
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.392
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3919
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4052
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.2451
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.404
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4145
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4047
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4043
Peroxisome_Homo sapiens_hsa04146 XDH 0.4145
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4499
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4487
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4616
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.4717
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4717
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4717
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4631
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.4701
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4832
Shigellosis_Homo sapiens_hsa05131 SRC 0.4717
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4717
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.475
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.501
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5327
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5805
Malaria_Homo sapiens_hsa05144 MET 0.5439
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5479
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5476
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5479
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.4976
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6068
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.8536
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5547
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4828
DNA replication_Homo sapiens_hsa03030 POLA1 0.6341
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6751
Base excision repair_Homo sapiens_hsa03410 POLB 0.6643
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7867
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6772
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.706
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6751
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7009
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8156
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.8745
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1394


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)