TCM Prescription: Fu Fang Xi Ling Jie Du Pills



Prescription Description
Prescription IDTCMF3135
Pinyin NameFu Fang Xi Ling Jie Du Wan
Chinese Name复方西羚解毒丸
English NameFu Fang Xi Ling Jie Du Pills
Function Description感冒, 风温
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH1142 Schizonepetae spica 荆芥穗 TCMH1142
TCMH1562 Arctium lappa 牛蒡子 TCMH1562 ITSAI1776-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH420 Lophatherum gracile 淡竹叶 TCMH420 GBVY2724-14, GBVT2442-13
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH396 Semen sojae praeparata 淡豆豉 TCMH396
TCMH1294 Cornu saigae tataricae 羚羊角 TCMH1294
TCMH1997 Bubalus bubalis 水牛角 TCMH1997 GBMA0080-06
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4 11.8572
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, RORC, SRC, THRA, THRB 11.5533
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TYR, XDH 10.8165
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, NR1H4 10.5642
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, RORC, SRC, THRA, THRB 10.4503
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PIM1, RORC, SRC, THRA, THRB 10.2204
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR1H4, NR3C1, RORC, SRC, TYR 9.31231
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, RORC, THRA, THRB 9.31231
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, NR1H4, NR3C1, RORC, SRC, TYR 9.18148
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 9.13122
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MET, NR1H4, SRC, THRA, THRB, TNKS, TNKS2, XDH 9.03553
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, NR1H4, NR3C1, RORC, SRC, TYR 9.03553
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PGR, PIM1, SRC, XDH 8.64185
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTPN1, SRC, TNKS, TNKS2, XDH 8.61217
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TYR, XDH 8.61217
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTPN1, SRC, TNKS, TNKS2, XDH 8.60304
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, RORC, THRA, THRB 8.25416
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 8.06647
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4 7.85894
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TYR, XDH 7.74328
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TYR, XDH 7.71082
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, NR1H4, NR3C1, RORC, SRC, TYR 7.60656
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.56241
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APP, AR, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, KIT, MMP2, NR1H4, NR3C1, SRC 7.25054
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 7.25054
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTPN1, SRC, TNKS, TNKS2, XDH 7.15555
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 6.86622
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FUT7, GBA2, HMGCR, NR1H4, PIM1, TYR, XDH 6.85203
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 6.82533
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, RORC, SRC, THRA, THRB, TNKS2, TYR 6.78201
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, RORC, SRC, TYR 6.74725
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 6.71228
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.65351
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PGR, PIM1, RORC, SRC, THRA, THRB, TNKS2, TYR 6.61968
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR1H4, NR3C1, RORC, SRC 6.61117
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, NR1H4, NR3C1, RORC, SRC 6.61117
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, AR, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, NR3C1, SRC 6.47728
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PTPN1, SRC, THRA, XDH 6.43518
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1 6.39793
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 6.32066
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP2, MMP9, NR1H4, PTPN1, SRC, TNKS, TNKS2, XDH 6.26305
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DAO, GBA2, HMGCR, NR1H4, TYR 6.17777
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.17735
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, SRC, THRA, TYR 6.04269
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 6.03928
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PTPN1, SRC, THRA, XDH 5.87021
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.86603
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTPN1, SRC, THRA, TNKS, TNKS2, XDH 5.86603
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, PGR, SRC, THRA, THRB 5.86603
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, PTPN1, SRC, XDH 5.8071
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PTPN1, SRC, XDH 5.77213
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTPN1, SRC, THRA, TNKS, TNKS2, XDH 5.75021
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PTPN1, SRC 5.7431
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, SRC 5.68619
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, HMGCR, KDR, NR1H4, SRC, TNKS, TNKS2 5.56063
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.55243
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 5.40918
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.40384
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PTPN1, SRC 5.21654
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PGR, PIM1, RORC, SRC, THRA, TYR 5.19851
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MMP9, NR1H4, PIM1, PTPN1, SRC, THRA, XDH 5.16598
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, NR1H4, PTPN1, SRC, XDH 5.09658
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, NR1H4, PTPN1, SRC, XDH 5.09658
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HMGCR, KIT, NR1H4, RORC, SRC, THRA 4.88368
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2 4.8518
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTPN1, SRC, THRA 4.66489
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, KDR, KIT, MET, MMP2, MMP9, PGR, RORC, SRC, THRA, THRB 4.66273
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, NR1H4, PTPN1, SRC, THRA, TNKS, TNKS2, XDH 4.5707
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, HMGCR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PIM1, SRC, THRA, THRB, TNKS2, XDH 4.54386
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 4.5133
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.45603
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTPN1, SRC, THRA, TNKS, TNKS2, XDH 4.45603
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.45012
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.44064
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, HMGCR, KIT, MET 4.42711
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, APP, AR, FLT3, HMGCR, KDR, KIT, PTPN1, SRC, XDH 4.37899
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AR, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 4.37348
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, NR1H4, PIM1, PTPN1, SRC 4.33502
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, ESRRB, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 4.29386
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR1H4, NR3C1, RORC, SRC 4.21559
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.19052
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR1H4, NR3C1, PTPN1, RORC, SRC, THRA, TYR 4.15228
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR1H4, NR3C1, PTPN1, RORC, SRC 4.13859
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 4.13859
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 4.1239
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC, SRC 4.12333
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 4.12009
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, NR1H4, SRC 4.12009
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, NR1H4, PIM1, PTPN1, SRC, TNKS 4.10782
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 4.1064
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.1064
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR1H4, NR3C1, PGR, RORC, SRC, THRA, THRB, TNKS, TNKS2 3.98569
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, NR1H4, NR3C1, PGR, RORC, SRC, THRA, THRB, TNKS, TNKS2 3.92702
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DAO, ESR1, F3, FLT3, FUT7, GBA2, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.90631
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 3.90631
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, HMGCR, SRC, TNKS, TNKS2 3.89385
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.85532
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HMGCR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PIM1, SRC 3.81211
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, NR3C1, SRC 3.77357
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PGR, SRC 3.74449
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, APP, AR, FLT3, HMGCR, IGF1R, KDR, KIT, PTPN1, SRC, XDH 3.72989
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, NR1H4, NR3C1, PGR, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2 3.71853
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, NR1H4, PTPN1, SRC, XDH 3.65894
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.64154
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, APP, FLT3, KIT, PTPN1, SRC 3.62923
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, NR1H4, PTPN1, SRC, XDH 3.62058
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AR, BCL2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PTPN1, SRC, XDH 3.60769
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AR, BCL2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PTPN1, SRC, XDH 3.59232
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APP, AR, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, NR3C1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.57981
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TYR, XDH 3.55453
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR1H4, NR3C1, PGR, RORC, SRC, THRA, THRB, TNKS, TNKS2 3.52896
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.43816
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, ADRA2C, FLT3, KIT, PTPN1, SRC 3.43042
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, SRC, TYR 3.40491
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.3912
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.35234
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C, APP 3.35234
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 3.35017
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, ESR1, KIT, PGR, SRC, THRA, THRB 3.34948
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.32963
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.30805
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.2588
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, ESR1, FLT3, IGF1R, KIT, MMP2, NR1H4, NR3C1, SRC 3.25418
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.25418
[BP] GO:0071396 cellular response to lipid AR, AXL, CDK6, ESR1, FLT3, NR1H4, NR3C1, RORC, SRC 3.25418
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 3.24332
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.22896
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 3.21241
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.19541
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 3.17961
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, NR1H4, SRC 3.15789
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 3.15168
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, KIT, MET, MMP9, PTPN1, SRC, TNKS, XDH 3.12249
[BP] GO:0051094 positive regulation of developmental process ADRA2C, APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HMGCR, KDR, KIT, NR1H4, PIM1, SRC, THRA 3.12249
[BP] GO:0061097 None ADORA1, ADRA2A, ADRA2C, APP, PTPN1 3.1141
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.1141
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.08331
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.08331
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, KIT, PGR, RORC, SRC 3.08151
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, PGR, SRC 3.06672
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, HMGCR, IGF1R, KIT, MMP9, PTPN1, SRC, TNKS, XDH 3.06191
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC 3.04644
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, KDR, MMP12, MMP9, NR1H4, NR3C1, PGR, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.04644
[BP] GO:0051172 None ADRA2A, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, MMP12, MMP9, NR1H4, NR3C1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 3.04433
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, KIT, NR1H4, PIM1 3.00724
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 3.00593
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, TNKS, XDH 3.00593
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.00386
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HMGCR, HSD11B2, KIT, MMP2, SRC, THRA, TYR 3.00045
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, FABP3, HMGCR, HSD11B2, KDR, NR3C1, SRC 2.99349
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 2.99235
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CDK6, CYP19A1, ESR1, F3, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, NR1H4, PTPN1, SRC, XDH 2.99173
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 2.99173
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.99139
[BP] GO:0030154 cell differentiation ALPL, AR, AXL, BCL2, CBR1, CDK6, CYP1A1, ESR1, FABP4, FLT3, FUT7, HMGCR, KDR, KIT, MMP2, MMP9, RORC, THRA, THRB 2.96489
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 2.96427
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC, TNKS 2.96427
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 2.9429
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.92341
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 2.92341
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 2.92341
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, AR, BCL2, CDK6, CYP19A1, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PTPN1, SRC, XDH 2.9216
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.91007
[BP] GO:0008050 None THRA, THRB 2.89749
[BP] GO:0009115 None AOX1, XDH 2.89749
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, HMGCR, IGF1R, MET, MMP9, NR1H4, PTPN1, SRC, XDH 2.88974
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.87424
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, HMGCR, IGF1R, KIT, MET, MMP9, NR1H4, PIM1, PTPN1, SRC, TNKS, XDH 2.85049
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.825
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO 2.82089
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, NR1H4, SRC 2.81094
[BP] GO:0061098 None ADORA1, ADRA2A, ADRA2C, PTPN1 2.80655
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9 2.8027
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.79955
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, ESR1, F3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.78721
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.78396
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, NR3C1, SRC 2.77078
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.76158
[BP] GO:0050793 regulation of developmental process ADRA2C, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, HMGCR, KDR, KIT, NR1H4, PIM1, RORC, SRC, THRA, TNKS2, XDH 2.73515
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, DAO, HMGCR, TYR 2.67128
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.67128
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.65907
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, ADRA2C, APP, CA2, HMGCR, MMP12, NR1H4, PTPN1, SRC, THRA 2.64991
[BP] GO:0045893 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR1H4, NR3C1, PGR, RORC, SRC, THRA, THRB, TNKS 2.64837
[BP] GO:1903508 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR1H4, NR3C1, PGR, RORC, SRC, THRA, THRB, TNKS 2.64837
[BP] GO:1902680 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR1H4, NR3C1, PGR, RORC, SRC, THRA, THRB, TNKS 2.64644
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.6384
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.62909
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.60465
[BP] GO:0045934 None ADRA2A, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, MMP12, NR1H4, NR3C1, RORC, SRC, THRA, THRB, TNKS, TNKS2 2.58826
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, APP, AR, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, ESR2, ESRRA, ESRRB, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4, NR3C1, NR3C2, PGR, RORC, THRA, THRB, TYR, XDH 2.54081
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.53375
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.53375
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.52252
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, NR1H4, PTPN1, SRC, TNKS, TNKS2 2.50568
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.50568
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC 2.50568
[BP] GO:0060748 None AR, PGR 2.50568
[BP] GO:0046110 None AOX1, XDH 2.50568
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.50568
[BP] GO:0006808 regulation of nitrogen utilization BCL2, NR1H4 2.50568
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.50172
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.49793
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.48854
[BP] GO:0007617 None APP, THRA, THRB 2.48854
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.48854
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.48854
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.48854
[BP] GO:0051254 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR1H4, NR3C1, PGR, RORC, SRC, THRA, THRB, TNKS 2.43965
[BP] GO:0001503 ossification ALPL, BCL2, MMP2, MMP9, THRA 2.38258
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.38258
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, NR1H4, SRC, TNKS 2.38047
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.37532
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.36885
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, APP, AR, BCL2, CSNK2A1, HMGCR, MMP12, NR1H4, PTPN1, SRC, THRA 2.36542
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.35526
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, BCL2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PTPN1, SRC, XDH 2.35526
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, ADRA2C, APP, BCL2, HMGCR, MMP9, NR1H4, THRA 2.33837
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.33179
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, NR3C1, SRC 2.33036
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TYR, XDH 2.32207
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.32207
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C 2.26715
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.26715
[BP] GO:0046888 None ADORA1, ADRA2A, ADRA2C, HMGCR 2.26715
[BP] GO:0035625 None ADRA2A, ADRA2C 2.26715
[BP] GO:0032811 None ADRA2A, ADRA2C 2.26715
[BP] GO:0070213 None TNKS, TNKS2 2.26715
[BP] GO:0006145 None AOX1, XDH 2.26715
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.26715
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, NR1H4, SRC 2.26715
[BP] GO:2000026 regulation of multicellular organismal development ADRA2C, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, F3, HMGCR, KDR, KIT, NR1H4, PIM1, SRC, XDH 2.26225
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.25329
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUT7, GBA2, XDH 2.24594
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.23555
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRA2A, APP, AR, AURKB, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HMGCR, IGF1R, KDR, KIT, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, RORC, SRC, THRA, THRB, TNKS, TNKS2 2.23555
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.23555
[BP] GO:0006940 None ADORA1, ADRA2A, ADRA2C, KIT 2.23555
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC 2.22022
[BP] GO:0000122 None AR, AURKB, ESR1, ESR2, ESRRA, MMP12, NR1H4, NR3C1, RORC, THRA, THRB 2.20854
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.19106
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, NR1H4, PTPN1, SRC 2.19106
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, KIT, MET, SRC, XDH 2.15837
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.14655
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.14655
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.14655
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.14655
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, NR1H4 2.14655
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, BCL2, CDC25B, ESR1, F3, FLT3, KIT, PTPN1, SRC, TNKS, XDH 2.14655
[BP] GO:0045944 None APP, AR, ESR1, ESRRA, ESRRB, MET, MMP12, NR1H4, NR3C1, PGR, THRA, THRB, TNKS 2.14655
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ADRA2C, APP, AR, BCL2, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.14655
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.14328
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, NR1H4 2.13843
[BP] GO:0010629 None APP, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, KDR, MMP12, NR1H4, NR3C1, PGR, RORC, SRC, THRA, THRB, XDH 2.12357
[BP] GO:1900078 None ESRRA, NR1H4, SRC 2.11098
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.11098
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.10199
[BP] GO:0001775 cell activation ADRA2A, ADRA2C, ALOX5, APP, AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC, SRC 2.10199
[BP] GO:0043696 None CDK6, ESRRB 2.10199
[BP] GO:0043697 None CDK6, ESRRB 2.10199
[BP] GO:0035624 None ADRA2A, ADRA2C 2.10199
[BP] GO:0010641 None F3, SRC 2.10199
[BP] GO:0060509 None THRA, THRB 2.10199
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.10199
[BP] GO:0014060 None ADRA2A, ADRA2C 2.10199
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.08214
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.08128
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1 2.07684
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HMGCR, HSD11B2, SRC, TYR 2.06559
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.06559
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, APP, BCL2, HMGCR, MMP12, NR1H4, PTPN1, SRC, THRA 2.06498
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, FLT3, KIT, PTPN1, SRC, TNKS 2.06496
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, NR1H4, SRC 2.06391
[BP] GO:0043433 negative regulation of DNA binding transcription factor activity ADORA3, CYP1B1, ESR1, NR1H4, PIM1 2.05536
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 2.04792
[BP] GO:0019098 None APP, THRA, THRB 2.0464
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, NR1H4, TNKS, TNKS2 2.04559
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9 2.0307
[BP] GO:0045892 None AR, AURKB, ESR1, ESR2, ESRRA, FABP4, MMP12, NR1H4, NR3C1, RORC, SRC, THRA, THRB 2.01933
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.01117
[BP] GO:0050678 None AR, CDK6, F3, KDR, MMP12, PGR, XDH 2.01059
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.01059
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.01059
[BP] GO:0010628 positive regulation of gene expression APP, AR, ESR1, ESR2, ESRRA, ESRRB, KIT, MET, MMP12, NR1H4, NR3C1, PGR, RORC, SRC, THRA, THRB, TNKS 2.01059
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, SRC, THRA, TNKS, TNKS2, TYR, XDH 3.25418
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TYR, XDH 2.63776
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTPN1 2.51523
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, NR3C2, PGR, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR 2.3551
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, NR3C2 2.2382
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, THRA, THRB, TNKS, TYR, XDH 19.9259
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, RORC, THRA, THRB 13.8558
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, RORC 13.7079
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TYR, XDH 11.5533
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, PGR, RORC, THRA, THRB 11.5316
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, PGR, RORC, THRA, THRB 11.5316
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PTPN1, RORC, THRA, THRB, TNKS 11.2688
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 8.61217
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.20699
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, THRA, THRB, TNKS, TNKS2, TYR, XDH 7.56241
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 7.56241
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 7.56241
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, THRA, THRB, TNKS, TNKS2, TYR, XDH 7.23726
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, NR3C2, PGR, RORC, THRA, THRB 7.16292
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, RORC 7.16292
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, NR3C2, PGR, RORC, THRA, THRB 6.71871
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, NR3C2, PGR, RORC, THRA, THRB 6.2884
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, NR3C2, PGR, RORC, THRA, THRB 5.57676
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.57676
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.38058
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1, THRA, THRB 5.27208
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.11999
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.01153
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.70834
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.66489
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, HMGCR, HSD11B2, HSD17B1, SRC, XDH 4.60277
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.28453
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.16142
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.03364
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.75862
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, ADRA2C, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, XDH 3.65306
[MF] GO:0004887 None NR1H4, THRA, THRB 3.63546
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PGR, TYR, XDH 3.48772
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.45812
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, ESR1, ESR2, ESRRB, F3, HMGCR, KIT, MET, NR3C1, PGR, PTPN1, SRC, THRB, TNKS2 3.35234
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.35234
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.3288
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.32256
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.12778
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PTPN1, SRC, THRA 3.06109
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.99173
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, THRA, THRB, XDH 2.96427
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.89749
[MF] GO:0003845 None HSD11B1, HSD11B2 2.89749
[MF] GO:0043565 None AR, BCL2, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, NR3C2, PGR, RORC, THRA, THRB 2.84192
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.7935
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.7781
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.77078
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PTPN1, SRC, THRA 2.74179
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.50568
[MF] GO:0004938 None ADRA2A, ADRA2C 2.50568
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.48854
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.42085
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NR1H4, PIM1, SRC, XDH 2.32834
[MF] GO:0000981 None AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, RORC, THRA, THRB 2.29184
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.26715
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.26715
[MF] GO:0032795 None ADORA1, ADRA2A 2.26715
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.26715
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.25367
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.20854
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, ADRA2C, AOX1, AR, AXL, BCL2, DAO, FLT3, HMGCR, KIT, TYR, XDH 2.14655
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.10199
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.10199
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.08128
[MF] GO:0044212 None AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, PGR, RORC, THRA 2.00947
[MF] GO:0001067 None AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, PGR, RORC, THRA 2.00618


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 10.3648
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.8248
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.0099
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, HMGCR, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.2318
Pathways in cancer_Homo sapiens_hsa05200 AR, CDK6, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R 4.7778
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.334
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.1104
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.0744
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.0744
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.6191
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8716
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 THRB, THRA, ADORA3, ADORA1, NR3C1, ADRA2C, ADRA2A 3.3629
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8693
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.2057
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.2057
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.5444
Bile secretion_Homo sapiens_hsa04976 CA2, NR1H4, HMGCR, CYP3A4 3.0834
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.3641
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 2.3222
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KIT, KDR, BCL2, MET, IGF1R 2.2167
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 THRB, THRA, SRC, ESR1 2.3348
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.0885
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.2375
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.0787
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.0885
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA2C, ADRA2A 1.9694
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.0787
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.0861
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0787
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8794
Prostate cancer_Homo sapiens_hsa05215 AR, BCL2, IGF1R 1.8713
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.0861
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.7794
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.6191
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.5931
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.4401
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6124
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3387
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0657
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9462
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.0063
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3588
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3154
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9974
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0954
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2889
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0848
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1577
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 0.9462
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0559
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9259
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8435
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.9007
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.1159
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9259
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8262
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2603
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9007
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8333
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.334
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6313
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6934
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6313
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.3108
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2346
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2812
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3155
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3278
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3373
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1 0.2996
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3155
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3373
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3785
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3523
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3705
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3785
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3773
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.3761
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3888
Platelet activation_Homo sapiens_hsa04611 SRC 0.4114
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4134
Axon guidance_Homo sapiens_hsa04360 MET 0.401
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.4406
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4406
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, NR3C2 1.6124
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4865
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4748
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4785
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4785
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4864
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5031
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4785
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4864
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4865
Gap junction_Homo sapiens_hsa04540 SRC 0.4865
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4865
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5361
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5146
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5352
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5662
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5662
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6708
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5662
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7794
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5533
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5712
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5662
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5662
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5662
Shigellosis_Homo sapiens_hsa05131 SRC 0.5662
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.7841
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5935
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.658
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7359
Malaria_Homo sapiens_hsa05144 MET 0.6313
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6313
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6256
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO 0.6287
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6313
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6313
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.945
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.6826
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.776
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7924
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8262
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7838
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8162
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8719
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9259
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0037
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0562
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2895


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)